1.21.98.2: dichlorochromopyrrolate synthase
This is an abbreviated version!
For detailed information about dichlorochromopyrrolate synthase, go to the full flat file.
Reaction
2 3-(7-chloroindol-3-yl)-2-iminopropanoate + = + + 2 H2O
Synonyms
EC 1.21.3.9, EC 4.3.1.26, RebD
ECTree
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General Information
General Information on EC 1.21.98.2 - dichlorochromopyrrolate synthase
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metabolism
a key enzyme in the biosynthetic pathways leading to indolocarbazole natural products
metabolism
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the enzyme is involved in the pathway for the biosynthesis of rebeccamycin, i.e. 1,11-dichloro-12-(4-O-methyl-beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, overview. H2O2 produced from the RebO reaction with Trp to form indole-3-pyruvic acid imine can be used to form Cpd I (state of a hemoprotein that is 2 equivalents of oxidation greater than the ferric form and contains an oxoferryl center (FeIV=O) plus a porphyrin p-cation radical) on RebD, and the Cpd I then via radical chemistry forms the C-C bond that links the tryptophan moieties in chromopyrrolic acid
metabolism
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a key enzyme in the biosynthetic pathways leading to indolocarbazole natural products
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