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1.14.19.24: acyl-CoA 11-(E)-desaturase

This is an abbreviated version!
For detailed information about acyl-CoA 11-(E)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.24

Reaction

an acyl-CoA
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
an (11E)-enoyl-CoA
 + 2 ferricytochrome b5 + 2 H2O

Synonyms

(E)-11 myristoyl CoA desaturase, acyl-CoA Z/E11 desaturase, CroDELTA11 desaturase, DELTA11 desaturase, DELTA11-desaturase, desaturase, myristoly coenzyme A (E)-11, EC 1.14.99.31, EDELTA11, LATPG1, More, myristoyl-CoA 11-(E) desaturase, Z/E11 desaturase, Z/EDELTA11

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.24 acyl-CoA 11-(E)-desaturase

Engineering

Engineering on EC 1.14.19.24 - acyl-CoA 11-(E)-desaturase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D258E
site-directed mutagenesis, mutating the aspartic acid into glutamic acid transforms the Choristoneura parallela enzyme into a desaturase with Choristoneura rosaceana-like activity that produces a mixture of (11Z)-tetradecenoate and (11E)-tetradecenoate in a 64:36 E/Z product ratio
16del_E
site-directed mutagenesis, the product E/Z isomer ratio is 33:67
A161G_T163M
site-directed mutagenesis, the product E/Z isomer ratio is 36:64
A88S
site-directed mutagenesis, the product E/Z isomer ratio is 32:68
E258D
F252L
site-directed mutagenesis, the product E/Z isomer ratio is 33:67
H116N_I118V
site-directed mutagenesis, the product E/Z isomer ratio is 42:58
I103M
site-directed mutagenesis, the product E/Z isomer ratio is 36:64
I174V
site-directed mutagenesis, the product E/Z isomer ratio is 35:65
I65V
site-directed mutagenesis, the product E/Z isomer ratio is 35:65
K286Q
site-directed mutagenesis, the product E/Z isomer ratio is 35:65
K309N
site-directed mutagenesis, the product E/Z isomer ratio is 34:66
L12M
site-directed mutagenesis, the product E/Z isomer ratio is 31:69
L19W
site-directed mutagenesis, the product E/Z isomer ratio is 34:66
L69I
site-directed mutagenesis, the product E/Z isomer ratio is 30:70
M250I_T251A
site-directed mutagenesis, the product E/Z isomer ratio is 35:65
N259S
site-directed mutagenesis, the product E/Z isomer ratio is 31:69
Q33E
site-directed mutagenesis, inactive mutant
S109A
site-directed mutagenesis, inactive mutant
T95A
site-directed mutagenesis, the product E/Z isomer ratio is 35:65
V321I
site-directed mutagenesis, the product E/Z isomer ratio is 35:65
W45G
site-directed mutagenesis, the product E/Z isomer ratio is 31:69
additional information