1.14.14.55: quinine 3-monooxygenase

This is an abbreviated version!
For detailed information about quinine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.55

1.14.14.55

cyp2d6

cyp1a2

drug-drug

hepatocytes

midazolam

ketoconazole

p-glycoprotein

dosing

xenobiotics

drug-metabolizing

concentration-time

clopidogrel

testosterone

disposition

interindividual

pharmacodynamics

pharmacogenetic

pregnane

omeprazole

coadministration

rifampicin

antiplatelet

erythromycin

open-label

dextromethorphan

phenobarbital

tacrolimus

ritonavir

coadministered

n-demethylation

itraconazole

grapefruit

tolbutamide

quinidine

first-pass

warfarin

carbamazepine

androstane

phenytoin

clarithromycin

voriconazole

pharmacogenomics

methadone

p450-mediated

infinity

ugt2b7

efavirenz

ugt1a1

vkorc1

saquinavir

medicine

Reaction

Synonyms

CYP2C19, CYP3A, CYP3A4, CYPIIIA4, cytochrome P450 isoform, EC 1.14.13.67, NF-25, Nifedipine oxidase, P450-PCN1, quinine 3-hydroxylase, Quinine 3-monooxygenase, quinine monooxygenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.55 quinine 3-monooxygenase

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Results	in table
7	Activating Compound
26	AA Sequence
2	Application
1	CAS Registry Number
2	Cloned(Commentary)
4	Cofactor
6982	Disease/ Diagnostics
1	General Information
18	IC50 Value
78	Inhibitors
1	Ki Value [mM]
11	KM Value [mM]
13	Localization
10	Natural Substrates/ Products (Substrates)
19	Organism
57	PDB ID
1	pH Optimum
2	Protein Variants
1	Purification (Commentary)
1	Reaction
3	Reaction Type
19	Reference
18	Source Tissue
23	Substrates and Products (Substrate)
23	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.14.55 - quinine 3-monooxygenase

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0.097

cimetidine

Homo sapiens

at pH 7.4 and 37°C

744609

0.127

diltiazem

Homo sapiens

at pH 7.4 and 37°C

744609

0.017

doxycycline

Homo sapiens

at pH 7.4 and 37°C

744609

0.061

erythromycin

Homo sapiens

at pH 7.4 and 37°C

744609

0.197

hydralazine

Homo sapiens

at pH 7.4 and 37°C

744609

0.000026

ketoconazole

Homo sapiens

at pH 7.4 and 37°C

744609

0.023

ketoconazole 2R,4R enantiomer

Homo sapiens

pH 7.4, 37°C

686501

0.014

ketoconazole 2R,4S enantiomer

Homo sapiens

pH 7.4, 37°C

686501

0.011

ketoconazole 2S,4R enantiomer

Homo sapiens

pH 7.4, 37°C

686501

0.004

ketoconazole 2S,4S enantiomer

Homo sapiens

pH 7.4, 37°C

686501

0.01

ketoconazole racemate

Homo sapiens

pH 7.4, 37°C

686501

0.038

nifepidine

Homo sapiens

at pH 7.4 and 37°C

744609

0.143

oleandomycin

Homo sapiens

at pH 7.4 and 37°C

744609

0.018

Omeprazole

Homo sapiens

at pH 7.4 and 37°C

744609

0.02

primaquine

Homo sapiens

at pH 7.4 and 37°C

744609

0.029

tetracycline

Homo sapiens

at pH 7.4 and 37°C

744609

0.0083

troleandomycin

Homo sapiens

at pH 7.4 and 37°C

744609

0.064

verapamil

Homo sapiens

at pH 7.4 and 37°C

744609