1.13.11.77: oleate 10S-lipoxygenase
This is an abbreviated version!
For detailed information about oleate 10S-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.77
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1.13.11.77
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indoleamine
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oleic
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nostoc
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aeruginosa
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hydroperoxide
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l-tryptophan
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nicotinamide
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cyclooxygenases
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punctiforme
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indole
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2,3-dioxygenases
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nad+
- 1.13.11.77
- indoleamine
-
oleic
- nostoc
- aeruginosa
- hydroperoxide
- l-tryptophan
- nicotinamide
-
cyclooxygenases
- punctiforme
- indole
-
2,3-dioxygenases
- nad+
Reaction
Synonyms
(10S)-dioxygenase, (10S)-DOX, 10-dioxygenase, 10S-dioxygenase, 10S-DOX, 10S-DOX-like lipoxygenase, heme dioxygenase, linoleate 10S-dioxygenase, linoleate 10S-DOX, linoleate heme 10S-dioxygenase, LOX, Np-diox, Npun_R5469, oleate heme 10S-dioxygenase
ECTree
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General Information
General Information on EC 1.13.11.77 - oleate 10S-lipoxygenase
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evolution
linoleate 10S-dioxygenase is an ancient relative of cyclooxygenase in cyanobacteria, linoleate 10S-dioxygenase works in tandem with a catalase-related protein with specific 10S-hydroperoxide lyase activity. Neighboring cyanobacterial genes, dioxygenase and catalase, are identified as linoleate 10S-dioxygenase and 10Shydroperoxide lyase, respectively. The Nostoc linoleate 10S-dioxygenase, the sequence of which contains the signature catalytic sequence of cyclooxygenases and fungal linoleate dioxygenases (YRWH), appears to be a heme dioxygenase ancestor
metabolism
the immediate downstream gene, Np-cat, encodes a specific linoleate 10S-hydroperoxide lyase (10S-hydroperoxyoleate being metabolized at only 3% of the rate) converting the product of Np-diox and working in tandem with it
physiological function
enzyme Np-diox is an oleate and linoleate heme 10S-dioxygenase-alpha-linolenate is also efficiently metabolized at lower concentrations, but it much more rapidly leads to enzyme inactivation
physiological function
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the enzyme can be utilized by bacteria to detoxify free fatty acids released by wounded diatoms in the presence of copepods