1.13.11.48: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase

This is an abbreviated version!
For detailed information about 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase, go to the full flat file.

Reaction

Synonyms

1H-3-Hydroxy-4-oxoquinaldine 2,4-dioxygenase, 1H-3-hydroxy-4-oxoquinaldine oxygenase, 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase, HOD, HodC, More

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.48 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase

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Results	in table
20	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
2	Cofactor
3	Crystallization (Commentary)
2	General Information
10	Inhibitors
41	KM Value [mM]
2	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
27	Organism
24	PDB ID
1	pH Optimum
2	pH Range
1	pH Stability
41	Protein Variants
6	Purification (Commentary)
4	Reaction
3	Reaction Type
19	Reference
2	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
9	Subunits
39	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]
41	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.13.11.48 - 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase

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Ca2+

Arthrobacter sp.

1 mM, weak inhibition

207895

Co2+

Arthrobacter sp.

1 mM, weak inhibition

207895

Cu2+

Arthrobacter sp.

1 mM, strong inhibition

207895

Fe2+

Arthrobacter sp.

1 mM, strong inhibition

207895

guanidine hydrochloride

Paenarthrobacter nitroguajacolicus

Q7WSQ7

almost linear decrease of activity up to 1 M where activity vanishes, three-state unfolding of mutant enzyme; causes isothermal unfolding of mutant C69S in a three-state mechanism, thermodynamic analysis, overview

696277

Mg2+

Arthrobacter sp.

1 mM, weak inhibition

207895

Mn2+

Arthrobacter sp.

1 mM, weak inhibition

207895

Ni2+

Arthrobacter sp.

1 mM, strong inhibition

207895

Urea

Paenarthrobacter nitroguajacolicus

Q7WSQ7

causes isothermal unfolding of mutant C69S in a three-state mechanism, thermodynamic analysis, overview; nonlinear decrease of activity, activity lost at about 5 M, three-state unfolding of mutant enzyme

696277

Zn2+

Arthrobacter sp.

1 mM, strong inhibition

207895