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0.02 - 0.059
(abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
0.00008
(benzylamino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.16 - 0.2
(heptylamino)(oxo)acetic acid
0.047 - 0.133
(hexylamino)(oxo)acetic acid
0.088 - 0.2
(nonylamino)(oxo)acetic acid
0.0083 - 0.179
([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
0.00175 - 0.0114
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
0.0031 - 0.187
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
21
2,6-naphthalene disulfonic acid
Plasmodium falciparum
-
IC50: 21 mM
5.1
2,6-naphthalenedicarboxalic acid
Plasmodium falciparum
-
IC50: 5.1 mM
1.7
3,5-dihydroxy 2-naphthoic acid
Plasmodium falciparum
-
IC50: 1.7 mM
1.7 - 150
3,5-dihydroxynaphthalene-2-carboxylic acid
2.4
3,7-dihydroxy naphthalene-2-carboxylic acid
Plasmodium falciparum
-
IC50: 2.4 mM
2.4 - 5
3,7-dihydroxynaphthalene-2-carboxylic acid
0.00051 - 0.0144
3-([3-carbamoyldimethoxypyrimidin-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino)benzoic acid
0.0011
3-hydroxy-1,2-oxazole-4-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.000039 - 0.0022
3-[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]aminobenzoic acid
0.31 - 5.9
4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
0.00065
4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.00014
4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.016
4-hydroxy-1,2-oxazole-3-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
4.6 - 6.6
6,6'-disulfanediyldipyridine-3-carboxylic acid
6.6
6,6'-Dithiodinicotinic acid
Plasmodium falciparum
-
IC50: 6.6 mM
0.191 - 0.225
8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.52 - 1.1
8-(phenylamino)naphthalene-1-sulfonic acid
0.0873 - 0.232
8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.52
8-anilino-1-naphthalene sulfonic acid
Plasmodium falciparum
-
IC50: 0.52 mM
0.0944 - 0.116
amino(oxo)acetic acid
0.00005
cardiolipin
Sus scrofa
-
IC50: 0.00005 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5
5.5
Chloroquine
Plasmodium falciparum
-
IC50: 5.5 mM
4.6
methylmalonate
Rattus norvegicus
-
IC50: 4.6 mM (enzyme from brain), 4.6 mM (enzyme from liver)
1.4 - 5.11
naphthalene-2,6-dicarboxylic acid
9.8 - 21
naphthalene-2,6-disulfonic acid
0.15 - 0.2
oxo(pentadecylamino)acetic acid
0.0001
oxo[(2-phenylethyl)amino]acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.000035
oxo[(3-phenylpropyl)amino]acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.041 - 0.088
oxo[(4-phenylbutyl)amino]acetic acid
0.0188 - 0.2
oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
0.146 - 0.2
oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
0.0013
phosphatidylserine
Sus scrofa
-
IC50: 0.0013 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5
0.158 - 0.2
[(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
0.014 - 0.025
[(2-methoxyethyl)amino](oxo)acetic acid
0.035 - 0.09
[(3,3-diphenylpropyl)amino](oxo)acetic acid
0.031 - 0.043
[(3-methoxypropyl)amino](oxo)acetic acid
0.157 - 0.2
[(3-methylbutyl)amino](oxo)acetic acid
0.0979 - 0.107
[(3-methylphenyl)(phenyl)amino](oxo)acetic acid
0.00007
[(4-chlorobenzyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.00009
[(4-methylbenzyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.186 - 0.2
[(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
0.043 - 0.2
[(naphthalen-1-ylmethyl)amino](oxo)acetic acid
0.168 - 0.2
[benzyl(methyl)amino](oxo)acetic acid
0.043 - 0.2
[bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
0.046 - 0.169
[bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
0.059 - 0.101
[bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
0.032 - 0.2
[bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
0.051 - 0.2
[[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
0.02
(abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.059
(abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.16
(heptylamino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.2
(heptylamino)(oxo)acetic acid
Bos taurus
-
above, pH not specified in the publication, temperature not specified in the publication
0.047
(hexylamino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.133
(hexylamino)(oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.088
(nonylamino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.2
(nonylamino)(oxo)acetic acid
Bos taurus
-
above, pH not specified in the publication, temperature not specified in the publication
0.0083
([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.179
([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.00175
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.0114
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.0031
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.187
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
1.7
3,5-dihydroxynaphthalene-2-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
150
3,5-dihydroxynaphthalene-2-carboxylic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
2.4
3,7-dihydroxynaphthalene-2-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
5
3,7-dihydroxynaphthalene-2-carboxylic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00051
3-([3-carbamoyldimethoxypyrimidin-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino)benzoic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme, L-lactate oxidation
0.0144
3-([3-carbamoyldimethoxypyrimidin-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino)benzoic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme, pyruvate reduction
0.000039
3-[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]aminobenzoic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme, L-lactate oxidation
0.0022
3-[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]aminobenzoic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme, pyruvate reduction
0.31
4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
5.9
4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
4.6
6,6'-disulfanediyldipyridine-3-carboxylic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
6.6
6,6'-disulfanediyldipyridine-3-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.191
8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.225
8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.52
8-(phenylamino)naphthalene-1-sulfonic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
1.1
8-(phenylamino)naphthalene-1-sulfonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0873
8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.232
8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.0944
amino(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.116
amino(oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
1.4
naphthalene-2,6-dicarboxylic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
5.11
naphthalene-2,6-dicarboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
9.8
naphthalene-2,6-disulfonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
21
naphthalene-2,6-disulfonic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.15
oxo(pentadecylamino)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.2
oxo(pentadecylamino)acetic acid
Plasmodium falciparum
-
above, pH not specified in the publication, temperature not specified in the publication
0.041
oxo[(4-phenylbutyl)amino]acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.088
oxo[(4-phenylbutyl)amino]acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.0188
oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.2
oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
Bos taurus
-
above, pH not specified in the publication, temperature not specified in the publication
0.146
oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.2
oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
Bos taurus
-
above, pH not specified in the publication, temperature not specified in the publication
20.4
pyruvate
Faxonius virilis
-
anoxic enzyme, pH 7.2, 25°C
30.3
pyruvate
Faxonius virilis
-
aerobic control enzyme, pH 7.2, 25°C
0.158
[(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.2
[(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
Plasmodium falciparum
-
above, pH not specified in the publication, temperature not specified in the publication
0.014
[(2-methoxyethyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.025
[(2-methoxyethyl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.035
[(3,3-diphenylpropyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.09
[(3,3-diphenylpropyl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.031
[(3-methoxypropyl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.043
[(3-methoxypropyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.157
[(3-methylbutyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.2
[(3-methylbutyl)amino](oxo)acetic acid
Bos taurus
-
above, pH not specified in the publication, temperature not specified in the publication
0.0979
[(3-methylphenyl)(phenyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.107
[(3-methylphenyl)(phenyl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.186
[(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.2
[(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
Plasmodium falciparum
-
above, pH not specified in the publication, temperature not specified in the publication
0.043
[(naphthalen-1-ylmethyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.2
[(naphthalen-1-ylmethyl)amino](oxo)acetic acid
Bos taurus
-
above, pH not specified in the publication, temperature not specified in the publication
0.168
[benzyl(methyl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.2
[benzyl(methyl)amino](oxo)acetic acid
Plasmodium falciparum
-
above, pH not specified in the publication, temperature not specified in the publication
0.043
[bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.2
[bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
Plasmodium falciparum
-
above, pH not specified in the publication, temperature not specified in the publication
0.046
[bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.169
[bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.059
[bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.101
[bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.032
[bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
Bos taurus
-
pH not specified in the publication, temperature not specified in the publication
0.2
[bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
Plasmodium falciparum
-
above, pH not specified in the publication, temperature not specified in the publication
0.051
[[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.2
[[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
Bos taurus
-
above, pH not specified in the publication, temperature not specified in the publication