1.1.1.159: 7alpha-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 7alpha-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.159
-
1.1.1.159
-
chenodeoxycholic
-
cholic
-
testosteroni
-
bacteroides
-
thin-layer
-
3alpha-hydroxysteroid
-
synthesis
-
fragilis
-
7alpha-oh
-
glycochenodeoxycholic
-
nadp-dependent
-
ursodeoxycholic
-
perfringens
-
degradation
-
analysis
- 1.1.1.159
-
chenodeoxycholic
-
cholic
- testosteroni
- bacteroides
-
thin-layer
-
3alpha-hydroxysteroid
- synthesis
- fragilis
-
7alpha-oh
-
glycochenodeoxycholic
-
nadp-dependent
-
ursodeoxycholic
- perfringens
- degradation
- analysis
Reaction
Synonyms
7-alpha-HSDH, 7-HSDH, 7alpha-HSD, 7alpha-HSDH, 7alpha-hydroxy steroid dehydrogenase, 7alpha-hydroxysteroid dehydrogenase, Bile acid-inducible protein, CA 7alpha-HSDH, Ca7alpha-HSDH, dehydrogenase, 7alpha-hydroxy steroid, J-1-1, NADP(H)-dependent 7alpha-HSDH, NADP(H)-dependent 7alpha-hydroxysteroid dehydrogenase, NADP+-dependent 7alpha-HSDH, nicotinamide adenine dinucleotide phosphate-dependent 7alpha-hydroxysteroid dehydrogenase
ECTree
Advanced search results
Reaction
Reaction on EC 1.1.1.159 - 7alpha-hydroxysteroid dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Tyr159 acts as basic catalyst, Lys163 binds to NAD(H) and lowers the pKa value of Tyr159, Ser146 stabilizes the substrate, reaction intermediate and product in catalysis
-
cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADH + H+
catalyses the oxidation of the 7alpha-hydroxyl group of bile acids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+
-
-
-
cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADH + H+
belongs to the short-chain dehydrogenase/reductase 1 familiy (SDR), mechanism
cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oate + NADH + H+
short-chain dehydrogenase group
-