>Q59327|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Comamonas testosteroni|Swiss-Prot
MSNVKKHVSTINPVGEVLDVGSADEVQWSDASDVVVVGWGGAGASAAIEAREQGAEVLVI
ERFSGGGASVLSGGVVYAGAVPATRRKPASRFTEAMTAYLKHEVNGVVSDETLARFSRDS
VTNLNWLEKQGATFASTMPGYKTSYPADGMYLYYSGNEVVPAYGNPQLLKKPPPRGHRVV
AKGQSGAMFFAALQKSTLAHGARTLTQARVQRLVREKDSGRVLGVEVMVLPEGDPRTERH
KKLDELVAKSACIRRRVPRRVAVNVRRSRARSARSATSVPAKVWCCPLAAISSIRNCWSM
RRYKPGWLTGAAGCDGSGLRLGQSVGGIAQDLNNISAWRFITPPSVWPKGLVVNIQGERF
CNEQVYGAKLGYEMMEKQGGQAWLIIDSNVRRQAAWQCLFGGLWAFQSMPALALMYKVAI
KGKSVDDLAKKLRMDAAVLQLQFDRANAPARGEIEDPLGKSQDMRHEFKGGSLFAIDISI
SQKMFPLAVLSLGGLKVNEDNGAVIDGAGYDIPGLYAAGVPPLVWLPRVT
>B9SXZ3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Ricinus communis|TrEMBL
MKVTVVSRSGREVIKGGLDLNDSATVADLQEAIHKRTKKFYPSRQRLTLPLPPGSKDRPT
VLNYKKSLKDYCDGNSDNITVVFKDLGPQVSYRTLFFFEYLGPLILYPVFYFFPVYKYFG
YKEERVIHPVQTYAMYYWCFHYFKRIMETFFVHRFSHATSPLSNVFRNCAYYWTFGSYIA
YYVNHPLYTPVGDLQMKIGFGFGLICQIANFYCHILLKNLRSPDGSGGYQIPHGFLFNIV
TCANYTTEIYQWLGFNIATQTVAGYIFLVVAASIMTNWALAKHRRLRKLFDGKDGRPKYP
RRWVILPPFL
>C8PQD5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Treponema vincentii ATCC 35580|TrEMBL
MLVLGLICFFALYFIPAGYGKLIDKKWGFSFNNKAAWMLMECPTLIVMISLLSILDYAHK
PVRIVLVSFFLAHYIQRTLIFPMLLKGNSKMPLSIVSMGMLFNTINAFLIGLWIFYFSPA
EMYSVRWFADPRFIVGAALFCAGMFINIQSDSYIRSLRSNGDSKHYYPCKGMYRYVTSAN
YFGELVEWLGFAVLTWSSAGFLFLFWTACNLVPRSHALYKKYAQDFPEEFARYKPKRIIP
FVY
>V4ZLE7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii (strain ATCC 50861 / VEG)|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQEREIKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLPEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERCLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPTIACLSFVVATMTVNASKTHTWYRRTFGDAYPQNRRALLPLVY
>A0A852RRT6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardioides kongjuensis|TrEMBL
MSAPMVEADADVVVVGMGCAGAAAALEAARAGARVVALDRAAPGGSSAVSGGELYLGGGT
ALQQACGVDDDPDLMYAYLHEALGPHPDEDKLRLYCDGSVEHFEWFRGLGITFNPSLYDG
VSWLPPTADGLMWLGENAWPFTGLARPVPRGHRPATDGFGGWLLMDRLTTAVREAGVDVH
PDTRVTGLVQDDSGRVVGVRARRFGEDVTYRAHRGVVIATGGFADNAEMVADHAPVLIGH
SVVSDGLDDGSGIRLGVAAGGTLRRMASTQVALSVVPALAVRGMLVDGLGQRFVNEDVYP
GRFSQAAVRHRPGPWFTLVDERGWEDVPERERWGVQPAVVAETLAEVETELGLPPGSLED
TVARYNRDAAAGEDSLFHKDPRWLRPLEAPYAIVDATRGFDPEGTGSRGGTGVSGFTLGG
LRTSVDGEVLDASGVPVPGLYAAGRATSGIHGEGYVSGTSLGDGTFFGRRAGRAAAGC
>A0A7W6YWZ9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Paraburkholderia fungorum|TrEMBL
MQSPSFAQPESATPVEAPLVVDDPAAVRWDDVCDVLVAGFGAAGACAALEAAAAGAKVRI
VERFEGGGASAKSGGVVYAGGGTRYQSEAGYSDTPEAMFAYLRQEVGDAVSAVTLRRFCA
GSVDMLRWLERFGVRFAASVPPRKTSYPQNRYYLYYSGNEAVGDAVREHPPAPRGHRVVG
DGMSGRVLYDTLRRAVQAQPFVDTMCHASVRRLVTDRGGRVIGAQVWQVAPGRAQRAHRR
LARWAERLHNGMPAWADRLRAALHRVEQRAGRLITIKADAVVLSTGGFIFNRSMVAHYAP
RYLPNWRLGTTGCDGSGIRLGLSAGGVAERLERVSAWRFINPPYAWAQGCVVDRRGERFC
NEEVYGAALGHAMCETRDGHAWLILDARLVKQALKECLRGKLWAFQSVPAMLLMLAGRKR
AWSLAGLAARIGCDPAVLKRTVDAYNLGALNGVDRAFGKSAAMLQPLLHGPYYAIDISSD
SRVFPCPSITLGGLRVDETSNAVLSAQGTPIEGLFAAGRAACGLASNHYVSGLSLADCIW
SGRQAGRAAAGVVLANAAHFLTETD
>A0A7W7B0X8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphingosinicella soli|TrEMBL
MNPPANFDLGYDAIAPRITDAADQERWDEACDVLVVGMGIAGVSAALATSETGGGRSVLV
IDRFNGGGSSSLSGGVVYAGGGTKVQREAGVDDPTEAMLAYLVEETGGAVSTETLRRFCT
TSPEMIEWLEGHGVRFSSKVAPRKASYPTRDGYLYLSGNETVQVYADHIPAAPRGHRVVA
APNLSERFLYRGGASLMMTLIRALRAAPGVREILHCRVDRLVVDKAGRVVGVDVYQIPVG
FNAWRHGKLQRISSHIALGDSKLAKWAWRKAASIEKRHARRRTITVRERTILAAGGFMRN
RAMVQHHAATYLDATPLGAQGDVGSGIRLGQGVGGVTAYMDSVSAWRFINPPYVWMRGIM
ISRRGERLTNEEQYGARLGAALFEKAEGRGWLILDSKIVEDGERELKLPETWIFQRMIAR
AMLKNGKKAVTVADLEKQLEITDGGLQKAVERYNQDIAASAPDEFGKSRDLCAPLLTGPF
YAVDVSSDVAGSPILAISLGGLAIDENTGAVLGTDNKPIAGLFAAGRSAVGLCSKSYISG
LSLADGIFSGRRAGSFICQ
>A0A086JJD8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii GAB2-2007-GAL-DOM2|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>K7WRF4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Anabaena sp. 90|TrEMBL
MKIKYPINFHKGLTFLIILGLMVLYHNFTIGAWVYLSLHGTYGFLWLLKDRIFPDKQWEQ
EIPASQGILTFVLLCLYWVAPFILISSGTVPPLPLVAVAISLNIAGVFLHFASDAQKYYT
LKYKTGLITEGFFAKCRNPNYLGEVLIYLAFSLLTQHWLPFVIQGLFIAMIFVPNMRKKD
QSLSRYPEFAEYKENSGLFFPKLFNSRSSQKEETTA
>A3GGS3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)|TrEMBL
MVSIEVKSRSKSLRSVTISDLTLDTPVKALVGQIAEKNRTSAARLRVTKYDDKTKKQQPL
DYSKSFLDNGIATKKIELFVKDLGPQISWRTVFMIEYFGPLLIHPLFYYVSGLYGSGSVI
HHTQTQQFAYLFVVLHFLKREYETVFVHKFSNDTMPVFNIFKNSSHYWILSGFNLAYFIY
GQDSSLYSSGFLKFLFKVNDLPSSYNYLLAGLFIFAEVSNGITHSILANVRKEDTKKYVI
PYGYGFDLVACPNYFFESVSWFAYALLVGNWSSWVFLFVATGQMWLWAVKKHKRYLKTFG
DEYKKLNRKIYVPYVI
>A0A375HV61|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cupriavidus neocaledonicus|TrEMBL
MAYDAVTPIHAPLRLDDPDAHPWQAACDAVVVGFGAAGACAALEAAHGGARVIVAERFEG
GGASTKSGGVVYAGGGTPYQRAAGHDDTPQAMAAYLRQETGGVVSDAMLQGFCENSRAMI
GWLEALGVRFAATVPPRKTSYPAQPYYLYYSGNEAVPAYAQHAAPAPRGHRVKGPGMSGH
TLYGVLRRAVEDNRQITVRRQCAARRLILDRDGAVVGVELWQLPPGRHQKRHARLARLAE
RLHNAVPALADRLRAQLLQLELRHAQPVAIRTGAVVLASGGFIFNRAMVARHAGKYRQAW
RLGATGCDGSGIRLGESAGGATRHLERVSAWRFINPPFAWARGCVVDAHGARIGNEETYG
ATLGHAICERHGGRAWLVLNRALAREALRECLGGRLWAFQAVPAALLLLAGARRAASVEA
LAGKLGMPGAALRATLDAYNAAARGERPDPAGKSAAMCASLETGPWLAIDISADSRIFPC
PAITLGGLAVEESSGRVLAAADGAPIPGLYAVGRTAVGIASNHYVSGLSLADCIWSGRNA
GRHLAQQPAGGRQAHTHQETTHEPTY
>A0A4R8S5J0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacteroides salmoniphilum|TrEMBL
MPGDVEVPSPDVVIVGYGVAGASAALAALERGASVAILERFDGGGASAISGGIYYAGGGT
NIQRDAGVEDTPELMLEYLQLEVGDAVKPETLQKFVDGSVDTLDWLQGYGVPFEGSLAPF
KTSYPTNDYYLYFSGSESSGMARAVTTPRQRGHRAFGRGVSGKALFAPLAASAERLGADV
WRQTRVTGLIVEDGRVVGVRGVTLKDAPQWVQRMYSRLTHYATKPGIYYPPMRKVLEGPA
YALERRFAKPFEIRANDGVVLSSGGFIANRELVERYAPAYRDGLQLGTAGDDGTALKLAE
PLNAATGHLDEISAWRFIVPPAAFLGSLLVDAKGQRMVDESRYGAALGKAIVQKAGGVGY
LVADKALVKRARQQLGSQTLWFQRIQAEAFLNVGRKRAGSIAAVAAKAGIDPELLARTVS
EHNRAIADGTPDPLGKPDDIRVPIEQGPFYLFNVSIKTNMLNPCPMLTLGGLVVDEETGA
VQTTSGTAIPGLYAAGRAAVGICSNSYVSGLSLADCVFSGRRAGTETGRHIDA
>Q4MZ35|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Theileria parva|TrEMBL
MDLLLKNHKGQFMERVNFPVDGTVEDFKTFFYEKHRFYPERQRWTVNSLTGPVLTGNKLT
ENGVTDGTSLYFKDLGVQISWRLVFFMEYLGPLFILPLLYFFPSFFYRTEPLIRYCSQKC
GFVMLMFHFLKREFETFFVHRFSKETMPIKNLFTNCFHYWVLCAIGIGYYLFHPNYRPVL
FFTRGAEKIILFALFFLFQFLTFMTHLTLCRLRPKGTVVRGIPRDWGFQYVSCANYFWEL
LIWVDIALFVNTLTGYFFAFAVFLILANWAKKKHNKYLKEFPNYPKNRKALIPFLF
>Q57XE1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma brucei brucei (strain 927/4 GUTat10.1)|TrEMBL
MMISQSHSPFTEAGGFAAAVTLLFTAMGMVILSSHLMPLTGTRVLELSSKIHLTMAAGTF
LLLRFALIAPFGKHSGLSTVRIRVPALLSWSLQECPTLLSIIYYIVVEYPCYVHQCNPLQ
WLHMILDRPSMEVTTTVASAAPTLRLGLLFFAVHYFNRSVLYPLRVANHGTSVPLHITLS
AMLYCALNGRLQLLANIDSVDASQRLVVDSTWQTILTILGAVIFFAGMLVNVTSDCYLIR
LKKRPPLGAYKIPYGGLFVFVSCANFFGEIVEWFGYVAVVYGTNGTVAGLAALSFAAYVV
ANLLPRAYAHHQWYIQHFGAEYTALQRRAVIPFVY
>A0A088RSU6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania panamensis|TrEMBL
MKVIVASGQNGSRKHEVELAANATLADLKKAYRSEVDVHRKSFKVPGPIAAGGSAPTADG
TKPRPNLITLSEKMPLSQQGVKDGTVITYKDLGPQIGYRTVFYVEYAGPIAFMLLYAMRP
SFIYGSAPMPAYGYTQKLYIGLFIAHFLKRELESMFVHKFSHPTMPMRNIFKNCIYYWSF
AAFIGYVLCSPFFTATSAAQSNFGAVFMVINELLNFAVHYQLSTMRKSDGDTTRNVPQGP
LFALVSCPNYFFEIMSWVSFSIGTNMLSSWFFTLAGFVQMADWAKKKHRGYIKADPANKK
KAAILPFLM
>A0A2G8Y4T1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii COUG|TrEMBL
MAFSLPGMVPERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>U2XP71|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Candidatus Micropelagos thuwalensis|TrEMBL
MTESKAEIYGRWAEQLYQNGYDPLPLKGKKGMSGWTTFSMPDNEFERAEYIKKHKTKNIG
LRTGELVVIDIDEEEPEKIEIINQVMLQCLGPSDFIRIGRPPRKAYFYRTKTPIRKLQTG
GVEILGVGQQVVVAGIHPETKKPYSWPNESILDATLEDLPITTEDRLLNLNSALRDVYQF
KEADEPVTYLAAEGARNNSLFNYLRERALEVGSYNELEHLAFQMNETNIPPLRASEVISV
VNSVWKNRISNQIIPPGEQFAKFARKEHNSCTPDAFYLLATLKYTRDLEVYTIAQEATAN
YLGWGKNRLREALKVLLDNKIIFRVGEKCVPNRPRNAYLYSFHPPKHQ
>A0A425I2H9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii CAST|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRNAVIPFIV
>A0A7W7B4C5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphingosinicella soli|TrEMBL
MSAALEAAERGVDVLAIDRYDGGGSTAMNGGIFYAGGGTSIQKEAGFHDTPEDMFRYLKI
ETAGVIKDTTLRRFCDTSVETVNWLLAHGVKLNSRMFPKKWGYPDPRYFLYYSDNSLAPS
RAALARPAPRGHRMYHPPLKDGRYGQFLYKPLRDAASRSGVRAMPQTEVRQLILDRSGAV
VGVKVLMIPPNTQAWKDRQRHQNRANELMVLLPPSFPGARLTYAMAAKELAKVAKIEATH
RVELRFRATAGVCLSAGGFIYNRQMIHRYAAHHDATAPMGNPGDDGSGIRLGQTANGKVD
RMGRISSWRFLNPPSDWVKGMIVNADAERFVDETLYGASVGHALNEEQGGIGFLIFDSVV
NRRAWKELFTVKMLGYQRYPGILSMWGKAKAATIEQLAGKIGLDPAKLRQAVERYNRAAA
GVERDPMRKDQKEMLPISNGPFYAIDISASNTLLPMMAMTLGGLVVDEESGMVLDRNDRP
INGLYAAGRTAIGICSNVYMSGLSAADCVFSGRRVGEHVANGRRQGEERLR
>A0A1G4IAY7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma equiperdum|TrEMBL
MMISQSHSPFTEAGGFAAAVTLLFTAMGMVILSSHLMPLTGPRVLELSSKIHLTMAAGTF
LLLRFALIAPFGKHSGLSTVRIRVPALLSWSLQECPTLLSIIYYIVVEYPCYVHQCNPLQ
WLHMILDRPSMEVTTTVASAAPTLRLGLLFFAVHYFNRSVLYPLRVANHGTSVPLHITLS
AMLYCALNGRLQLLANIDSVDASQRLVVDSTWQTILTILGAVIFFAGMLVNVTSDCYLIR
LKKRPPLGAYKIPYGGLFVFVSCANFFGEIVEWFGYVAVVYGTNGTVAGLAALSFAAYVV
ANLLPRAYAHHQWYIQHFGAEYTALQRRAVIPFVY
>A0A7Y9ELM8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinomadura luteofluorescens|TrEMBL
MARPSVEPVGAAEAEPDHECDVLVVGFGAAGAAAAYEAAAGGADVLVLERSSGPGGTSAQ
SGGELYLGGGTRVQKACGFDDTPDDMFAFLTAALGPHADAEKLRLYCDGSVEHFEWFRSL
GVPFRESLFDAPGWMPYTEDGLMWLGENAWPYNEIARPAPRGHRPETPMFAGGILMEKLI
AAAAGAGAVAHQDTCATNLVVDAAGRVTGVVARRFGDRVVYRARRGVVLTSGGFVDNEEM
LADHAPVLLGHDKVSDGTSDGSGIRMATALGAATRRMASVEIALTANPAVICRGMLVDGL
GRRFINEDVYPGLFSHRAVQHQPGPYWAIIDEAGHDEIAEADMWGVRPKHAAETVAELEE
PLGLPPGSLEATVETYNRFAERGEDPYFHKDPRWLRPLKGPFAAIDPADGFFGAGGHGAG
TGAGGFTLGGLDTTVDGEVRNHSGEPIPGLYAAGRTASGIHGEGYISGTSLGDGTFFGRR
AGRAAAASENREATE
>A0A0B7F9T7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)|TrEMBL
MSFYRELLRDKSYKSYHLGLRAFASLGLLSPVLLVINAPHGRFSSDGASKTWITRAWDAL
SLDGTFSWIVMELPSPITLLYAFSQQSTLPGPSPLSLTPHSVLPLLFVGHYLNRAIISPL
RTPSRSKSHLIVVLAAIVFNVINGSVTGTWLGAGARTGSIGWADTPVSYWVGLAMFGLGL
WGNIWHDEVLLKIRKNRDGKKDDKPRYDIPYGGLYSLVSFPNYLCEWFEWTGFALASGSI
MTPLQQSLTLGHYGGVYITPAVLFTLVEVALMLPRAQRGHEWYHEKFSDYPKDRKAVIPF
LL
>A0A839XNQ2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Prauserella sediminis|TrEMBL
MPHREWDAEADVVIVGFGGAGACAAIDACDRGADVLVLDRFQGGGATAISGGVVYAGGGT
QHQRAAGFEDTTEAMLDYLRLETDGVVSDETLARFCEQSPDNLRWLERHGVPFEGSMAPR
KTSYPTNEHYLYYSGNELAPPFSDAAVPAPRGHRAKGAGVSGKPLFGALRRAVARRPIAV
RTQTKARRLVTDGERIVGVEVSEIGGRVPRGLHRVLAWAGRKLNIYYRPLGRMLDGPVAN
LERRHGVPRRYRARRGVVLAAGGFVFNRQLVAEHAPAYRRGSSLGTIADDGSGIALGESV
GGRADRLHRVSAWRFFNPPLAMVDGVLVNNRGERICNEAYYGARIGDRVARQPDSEAYLI
IDARTRAEALRQAPSQTLWFQRLQAEYVLRIGHVRATDLPTLARSRGIDPDGLAHTIEEY
NAGAAAGHDRMGKDPAHVHPLSSGPFYAIDCSIRTQPGFPIPMITLGGLTVDETTGAVTR
EDGSPVPGLYAAGRNAVGVCSESYVSGLSIADCVFSGRRVAAALTEKRFQEEQA
>A0A086LQU3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii RUB|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A7W9UKG9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardia transvalensis|TrEMBL
MVWDATTDVLVVGFGAAGACAGLEARAAGAEVLAVDRFNGGGATELSGGIVYAGGGTAVQ
REAGIGDTADAMFAYLAREVGDAVRPETLRRFVDSSPEMIDWLMGHGVPFEASVCTYKTS
YPDNRYYLYYSGSECSGEFRAVTPPVQRGHRAKGRGASGKMIYQPLARAAFAAGVRFRPH
TRVVALESDDSGRVIGVRARTMADAPASVRRSFAAMAAVAAKPGIYYPPLRRVLEGRLEA
LERRYAREIRIRARGGVILCAGGYIANREMLARYAPGYTGGLALGTTGDDGSGIELGLAA
GGTAERMDNVSAWRFIAPPSAFYSGLLVNEEGRRFIDETRYGAAVGNALVREQGGKGWLL
VDAALMGEARKQLASEAIWFQRLQAESMLRTSAVRADTVEEVARRAGISPEGLAATIRAH
NEAIAGDRPDPQGKPREFTHPIEKGPFTLLDVSVRPKLTNPCPMFSLGGLVVDENTGAAH
SSTGDPIPGLYVAGRSAIGICSESYVSGLSIADCVFSGRRAGRFASAELSETAA
>A0A7Y9S5Q1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardioides daedukensis|TrEMBL
MADVEFDHEVDVVVVGFGCAGAAAAQAAALAGASVVVLERASGPGGSSAQSGGELYLGGG
TAVQQACGFADDADNMFAYLASALGPNADLDKLRLYCDGSVEHFEWFRECGVEFTESLYD
APTWMPPTQDGLMWLGENAWPYTEQARPVPRGHRPSTEGWAGHTVMAALVAAAGSAGVET
HVDTRATSLVVDGDEVVGVVARKFGESVSYRARNGVVLTTGGFVDNEDMLADHAPALLGH
GKVSDGLDDGSGIALGQSVGGAIRRMASIEVAYTALPAMLVRGMLVNGLGQRFINEDAYP
GVFSHAAFHQPGPCWAIVDEAGLESIPEQDLWGVRPQHAAETLAELEIDLGLPIGSLEAT
VGLYNRHAADGVDGLFHKNPKWVRTLEGPWAAVDPRLGFAPAGRTGQTPGSGFSGFTLGG
LRTSVDGEVISLAGAPVPGLFAAGRATSGIHGDGYVSGTSLGDGTFFGRRAGRTVASRTG
SC
>A0A174MGU0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Bacteroides uniformis|TrEMBL
MNQETFQIFLWVMSAVALVVFIALYFVKAGYGMFRTASWGISINNKLAWVLMEAPVFIVM
FGLWGKSGAGFAVPVYFFFLLFQLHYLQRAFIFPFLLKGKSRMPVAIMAMGIVFNLLNGM
MQAGGLFYFAPEGLYADGWAYLLKPHALLGIILFFAGMFVNLHSDYVIRHLRKPGDTKHY
LPGKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWTFANLVPRADAIHRRYREEF
GDEAVGKRKRIIPFLY
>A0A8H2RSU3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MSSPDACTSVLGALRVADGQALQWDEHCDVLVIGWGAAGACAALEARAAGVDVLVADRFT
GGGASAKSGGVVYAGGGTPQQQAAGISDTPEAMFDYLKHETCGVVADATLRRFCEQSVAN
LGWLQGHGAPYGHTMPPGGKTSYPADGYFLYYSGNELVQSHTGRHPPAPRGHRTVGKGQC
GAVLYGHLKAACLRAGVRPLLQAAAKRLIQDAQGRVIGAELWRLPPASKAARTHARLAAR
AERWQNLAPGYCDTLRQRLARLEQEHARLYRVRAREGVILSTGGFIFNRDLVRQHAPAFR
RTFKVGATGCDGSGLRLGHSVGAASAGLARVSAWRFINPPHCWPKGIVVNRDGRRFCNEE
VYGATLGQPLMEEQGGHAWLVLDARLRRKAIGQALFGGYWWFQSLPALVLMLFKLRKGKT
PAQLAQAAGMQPGILSEALQAYNAAARGEQEDAFGKSLGSRQVLDQGPWYACDISVTNPV
FPLGALTLGGLKVDETTGAALDEHGQAIAGLYAAGRTAVGIPSHLYISGLSLADCVFSGR
RAGAAVAHAVQVPLTRKIVNL
>A0A4R8SM25|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacteroides salmoniphilum|TrEMBL
MPGDVEVPAVPSPDVVIVGYGVAGASAALAALERGASVTILERFDGGGASAISGGIYYAG
GGTNIQRDAGVEDTPELMLEYLQLEVGDAVKPETLQKFVDGSVDTLDWLQGYGVPFEGSL
APFKTSYPTNDYYLYFSGSESSGMARAVTSPRQRGHRAFGRGVSGKAMFAPLAASAERLG
ADVWRQTRVTGLIVEDGRVVGVRGVTLKDAPKWVQRMYSRLTHYATKPGIYYPPMRKVLE
GPAYALERRFAKPFEIRANDGVVLSSGGFIANRELVERYAPAYRDGLQLGTAGDDGTALK
LAEPLNAATGHLDEISAWRFIVPPAAFLGSLLVDAKGQRMVDESRYGAALGKAIVQKAGG
VGYLVADKALVKRARQQLGSQTLWFQRIQAEAFLNVGRKRAGSIAAVAAKAGIDPELLAR
TVSEHNRAIADGTPDPLGKPDDIRVPIEQGPFYLFNVSIKTNMLNPCPMLTLGGLVVDEE
TGAVQTTAGTAIPGLYAAGRAAVGICSNSYVSGLSLADCVFSGRRAGTETGRHTDA
>A0A086QGR0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii VAND|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGAS
QDAVEDQQERETKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALR
RCRLSLPEKNDTPVSALLSNASPDSIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLL
PLLLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQ
PLPSCSANAFPLSLEASPALFAASIQHVGEALVARATSRPGSVGMTFAAFLLVNCMQLHS
HMLLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEIL
IYLCLCLLLPSPPT
>J9H545|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|gut metagenome|TrEMBL
MGINLHSDRVIRHLRKPGDVNHYLPAKGLYRYVTSANYFGELVEWTGFAVLTASPAAWVF
VWWTFANLVPRAHAIHIHYQKEFGREAVGKRKRIIPFIY
>J9CHX6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|gut metagenome|TrEMBL
MKGKSRMPLTIVGMGVVFNVLNGIMQALGLFYLPVTDTVYSGGWHYFVSSHAILGMLLFF
LGMGINLHSDYVIRHLRQPGDTRHYLPTRGMFKYVTSANYLGELIEWIGFALLTISPAAG
VFVWWTFANLVPRAHAIHQHYRKEFGTLAVGTRKRIIPFIY
>C8PMQ9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Treponema vincentii ATCC 35580|TrEMBL
MSYFIYCTVEVVMLVLGLVCFFALYFIPAGYGKLIDKKWGFSFNNKAAWMLMECPTLIVM
LSLLFTLDYAHKPVRIVLVSFFLAHYIQRTLIFPMLLKGNSKMPLSIVSMGMLFNTINAF
LIGLWIFYFSPAEMYSVGWFGDPRFILGAVFFCAGMFINIQSDSYIRSLRTHGESKHYYP
CKGMYRYVTSANYFGELLEWFGFAVLTWSSAGFLFLFWTACNLVPRSHALYKKYAQDFPD
EVARYKPKRIIPFLY
>A0A375IPV1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cupriavidus taiwanensis|TrEMBL
MHPDSVTPVYAPLRLDDPDAHPWQAACDAVVVGFGAAGACAALEAAQGGARVIVAERFEG
GGASAKSGGVVYAGGGTSYQAAAGYADTPQAMADYLRQETGGVVSEAALQSFCERSRDML
AWLEGLGVRFAATVPPRKTSYPAQPYYLYYSGNEAVPAYARHATPAPRGHRVKGPGMSGR
TLYGVLRGAVEARTDITVMRQTAARRLIVDKNGSVIGIELWQVPPGRHQKRHARLARLAE
RLHNAMPGVADLLRRRVLQLELRHAQPVAVRTRAVVLATGGFIFNRAMVARHAGKYLQNW
RLGATGCDGSGIRLGESAGAAARHLERVSAWRFINPPFDWGRGCVVDAQGARIGNEETYG
ATLGHAICERHGGRAWLILDRALARAALRECLGGRLWAFQALPAAMLLLAGATRASSIEA
LAGKLGMPAAALRATLDAYSAAARGEIPDPAGKSAPMCASLETGPWVALDISANSRVFPC
PAITLGGLSVEESSGRVLAAADGAPEGAPIAGLYAVGRTAVGIASNHYVSGLSLADCIWS
GRNAGRHLAQQPAGHPIGGQQAHTHQETTHEPTY
>A0A7W7HQT8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinoplanes lobatus|TrEMBL
MDESATVVVVGFGAAGACAAIEAAEAGADVLVIDRFTGGGATAISGGVVYAGGGTRQQQA
AGVTDTPSAMYAYLRHEAGDAVSPATLRRFCDESADMLAWLEDHGVPFDARLCPYKTSYP
TNRHYLYQSGSEHAHPDPAPRGHRVHAPGTSGGTLHAHLAAAARALGVRFLPQTQAVSLI
LTPPPESSTAEPSSAASPGPQAAPSTASPLPGPQTATSTASPSSGSQAATSAAAPSPGPQ
TATSTAGAEHAERRVVGVECRTLRDAPAWARFAHRRLHRWSVKPGLYLPGFGRAMHRLAA
RIENRHGRTLRIHAGAVVLTAGGFVFDREMMQEHAPGYRGLRLGTPGDDGSGIRLGTEAG
AGVGHLGRVTLWRFLTPPSALLGGVLVDRDGHRFCDESRYGAALGDAILHRPGGRAWLLI
DATVLAEARRQLRSQTLWFQRLPAWWLLTVKRLHAPTLAQLAHGAGMDPSALAATVATNN
AAAAPGPGAGPSGPAAPGPGGGLSGSAVPGPGGGLSGSAVPGPGGGLSGSAVPGPGGGPS
GPAAPGDMAGLIAPHGTAAGGTCDSEATVRDAVGFDDFGKPLALVRPLVRPPFSLLDMSL
RASPAPMLTLGGLTVDEETGRVLRPGSTEIPGLYAAGRTAVGICSGSYVSGLSLADCVFS
GRRAGRDAAASLLSLRRSWAPGSRERWSTTQDRQGISESAPEADWQGISESVPEPDRLGI
PESAPESAPESAPESETAVRHTAAEASDPHPAGGAGQWGRTGG
>A0A841B9W2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Amycolatopsis umgeniensis|TrEMBL
MDSLVADVVIVGFGAAGACAAIEAADAGARVLVVERFSGGGASAVSGGVVYAGGGTAQQR
DAGVDDSVDAMYDYLRLEVGDVVSEETLRRFCAGSTEMVTWLEGNGVPFEGSLCPYKTSY
PSDAHYLYYSGSEAAGGFRDAAKPAPRGHRVKGPGTSGKLLMKRLAEAVRRRGIQVLPQT
AARNLIVDADGVVTGVVVSTLRDAPARVRATHRKLAAYAAKPGIYVPSLRKSLHRRVERI
ERRYGRELRISASRGVVLAAGGFIANREMVREHAPAYRGGLALGTSADDGSGIRMGVEAG
GATAELGRISAWRFITPPSAFLGGLLVDKAGGRIIDESRYGAAVGERMITEHEGRGWLLV
DDAIVRDVRRDARKQSQWFQGLQVRYLLRQRVVADSLEDVARKAGVDPGGLAASVEASRS
GADPTGKPAEFARPLDRAPYSLIDVSIKPNLGYPCPMLTLGGLVVDEGTGAVRASSGAPI
RGLYAAGRTAVGICSRSYVSGLSLADCVFSGRRAGAHSALDRGSVDKNENVF
>A0A5E7VRD4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATFDDSFCTPIQTPLQVADSSALLWDEHCDVLIIGWGAAGACSALEARAQGADVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVVSDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPQHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKDACLRAGARPLLQAAAKRLVVDAQGRVVGAEMWCMTPGTPQAQLHARLA
ARAERLQNFAAGYCKKLRQRIGQLERDFARPRLVHARNGVILSTGGFIFNRELIKRHAPK
FERNFKVGATGCDGSGLRLGTSVGGQGAALERVSAWRFINPPYSWHKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSLPALVLMLFKVRKG
KSLSELANATAMDPAVLRASVLAANAAARGEAPEPFGKSEGGRQVLEQGPFYACDISVTN
PVFPLGALTLGGLRVDERSGAVLDQQGQAIAGLYAAGRSALGIPSHLYISGLSLADCVFS
GRRAGAAVARPHGQQFETTHAHEMT
>Q8GTD7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cicer arietinum|TrEMBL
MKLTLVSRSGREIVKGGIQLSDSATVADLQEAIYKRIKKHPSRQRLTLPVQPGSKERPVV
LNYKKSLNDYTSGNSETLTLVFKDLGPQVSYRTLFFFEYLGPLLLYPVFYYLPVYQYFGY
KGERVIQPVQTYALYYWCFHYAKRILETFFVHRFSHATSPLSNVFRNCAYYWCFGSYIAY
YVNHPIIYPVSDLQMKIGFGFGILCQVSNFYCHIILRNLRGPAGEGGYQIPRGFLFNIVT
CANYTTEIYQWLGFNIATQTIAGYLFLAVATFIMTNWALAKHRRLKKLFDGKEGRPRYPR
RWVILPPFL
>A0A142B9P1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Endozoicomonas montiporae CL-33|TrEMBL
MTRQQSTEVPQALSIESADQFDWDDEQDVVVVGFGGAGVAAALEAVHQGASVLAVERFFG
GGATARSGGVVYAGGGTSIQKSEGVEDSPEQMFDYLKMEVEDAVSDETLRRFCDQSVTNL
QWLQHHNVEFSGNIPPVKTSYPTDQYYLYYSGNESVSSYAEKVKPAPRGHRVKGKGLSGE
VLFAALQKSAISRGVKLQIQTEATRLILDESRQVVGLEVRQIPVGSAAARKHRRLYRLAE
RCHNSARKLAFRLRDKLAVLERAEGVVKRIRARKGVVLSAGGFVMNQAMMDQHGGKYVGA
LQLGTSGCNGSGIRLGQGAGGATDRMNKISVWRFINPPIAFARGIAVNKDGVRFCSEDVY
GAKLGFEVVENQGNQASLIFNAELRKQALSQSIPGKLPFFQYMPALMAIFVASKKANTLA
ELAEYTGAPLETLVKTLHGYSKDARTNTRDALGKAESFMANLDEGPWYVLDLDVTNDKFP
CPMITLGGLQVNEATGEVLNEEGQEIKGLYSAGRNAVGVASHLYVSGLSIADCIFSGRRA
GRHVVQDDDDARTSAEKAPVEQQEVAEAV
>A0A447G7Y2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium basiliense|TrEMBL
MTRDRSAQETESTDVVVIGFGAAGVCAAIAAREQGVQVIALDRANGGGATAISGGIVYAG
GGTKVQQQAGVSDNFEQMLAYLRLEVGDAVSDQTLASFVRGSSEMIDWLTKYGVPFDSTL
CPYKTSFPNNRYYLYHSGSENAGAFRSHTPPVQRGHRVKGRGTSGKELYTPLAKSAVALG
VQFHPHTKARKLVQDSAGRVTGVEAFTMSHAPARVRRWYTTLAAVSTKPGIYYPPLRRMV
ERRLGRLERRYARPVRISARRGVIVCAGGFIANTEWVQRFAPQYLTGLQLGTSGDDGSGI
ALAQSVGAVTERMDNVSAWRFITPPSAFISAIVVDEKGQRIIDESRYGAAVGQAMVRDHG
GKGWLLADAALMKEARRQLIEQTLWFQRAQVAALMLTDSVRAPSLPEVARAAGIDPDGLL
ATVEAHNSAIDAGTPDPTGKPAEFVRRISQGPYTLLNISVRPSLLNPTPMLTLGGIKVDE
RTGAVVDDAGAAIPGLYSAGRTATGICSNSYVSGLSIADCVFAGRRAGTHAAAESHDQTS
DHPAR
>Q4DQY3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma cruzi (strain CL Brener)|TrEMBL
MLKRHGGNLSSTWAWLLVAVVFLLITTVCMVLLQQYVLPLGSTTVIESASYFHLVMAAMT
YFTLRFVEVAPFGRHATSTTAHVTMPAPLSWALQECPTLINVVYYLLMEYPCHALKCSSS
QWIRLVFDDPFGQAAHAISEGITSLHVGLLLFVIHYLHRTFLYPLIIGEGAPVPIKITLS
AAVYCLLNGRLQLLANIRDGPSAPRFPLLFTSHMALFWIGIVLFFAGMGVNVLSDNRLVR
LKKQPPRHSRKIPHGGLFEYVSCANFFGEIVEWCGYSLVVWSTTATTKPESGLAAFSFSV
YVMANLLPRGYAHHEWYKKQFGGAYDTLRRKAVIPYVY
>A0A2T6J3U9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii TgCATBr9|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQERETKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLAEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPT
>D4IJ89|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Alistipes shahii WAL 8301|TrEMBL
MKENFDIFLIVMALLAAVVYAALHFFEAGYGYLFDRRYGPPVPNRVGWMVMESPVFILMC
VLWASSERMWQAGPLALFCLFQAHYLQRAFIFPLLIRGKGRMPLGIVVMGMVFNTLNALM
QGGWIFYVSPADYYAGWFAQPYIYIGGALFVAGMAVNLHSDHIIRHLRRPGDTRHYIPRG
GMFRYVSSANYFGELLEWVGFAVASWSWAGTVFAWWTFANLAPRAASLRRRYEQEFGEEF
SRLRRKRIIPFIY
>A0A139XI01|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii ARI|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQERETKASIVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLPEKNDTPVSALLSNASPDSIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPTIACLSFVVATMTVNASKTHTWYRRTFGDAYPQNRRALLPLVY
>A0A853ALA1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Saccharopolyspora hordei|TrEMBL
MVQRSTLHADVVVIGFGAAGACAALEAASTGARVVVLDRFAGGGATALSGGVVYAGGGTD
VQRAAGVSDTPEAMFAYLRQEVGDAVSERTLRRFCEGSAEMVRWLAQHGVPFEGSLCPYK
TSYPSNRHYLYYSGSEAAGGFRDAAPPAPRGHRAKGRGTSGKVLHAALAAAVRRAGVRVL
TQTRARELVVDADGRVCAVDCERLTGPAARAHRVIGEVAAKPGLYVPKLARVLHRQVERL
ERRAEPLRVHADRAVVIAAGGFIANRQMLREHAPAYRGGLPLGTQGDDGSGIRLGQAVGG
ATAKLDRVSAWRFITPPSALLSGLVVGPSGTRIGDESRYGAALGQEVVEEHGRRAWLLID
QRVRRAARSQLRSQTVWFQRLQAEYLLATAATGDTLEAVAGKAGIDPRALADAVERHNRA
ARSGEPDPAGKPAEFVQVLDQPPYALLDLSVRPTVAYPCPMLTLGGLRVDEDTGQVLDVR
GDPVPGLFAAGRSAVGICSNSYVSGLSLADCVFSGRRAGLHSVKELTDADR
>A0A5E7UQZ4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MDSLNRLTALRVNSADQLPWDDRCDLLIVGFGGAGACAAIEASARGLSVLALDRFEGGGA
TALSGGVVYAGGGTPYQRQAGYEDSSEAMFNYLRQEVGEAVSGETLKHFCDGSREQLAWL
ERQGAAFEASVPPHKTSYPSDQYYLYYSGNEAVPSYAASAKPAPRGHRTQGPGMSGASLF
APLKASALRHGARLRSQCEVRRLVLDLDDKVIGVEAWQLPSGSRAAKQHARLSRWATAIH
MYAPALADRLRARQRRIEQSSAIRQLIRAEQAVLLSSGGFIFNRDLVRQHAPQYLAGLPL
GATGCNGSGIALGQSAGGSVARMDKVSAWRFINPPLAWARGLIVNARGQRYANEEIYGAT
LGHAMVEEQDGRAILVLNRELVREALRQVGPGKVWNFQRLPVLLNLLFNAKRSNSLAGLA
KRCNLPPELLRQSVERYSRAARGEVADEFGKSAAMLANLDQGPWYALDLSFDSKLFPCPV
ITLGGLKVCEDSGRVLDHAGQPINGLYSAGRNAVGVASNLYVSGLSLADCIFSGRRAAAH
VADQFALQTARSGEQQCNV
>A0A5E7CKM7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATFDDSFCTPIQTPLQVADSSALLWDEHCDVLIIGWGAAGACSALEARALGADVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVISDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPQHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKDACLRAGARPLLQAAAKRLVVDAQGRVVGAEMWCMTPGTPQAQLHARLA
ARAERLQNFAVGYCNKLRQRIGQLERDFARPRLVHARNGVILSTGGFIFNRELIKRHAPK
FLRNFKVGATGCDGSGLRLGTSVGGQGAGLERVSAWRFLNPPYSWHKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSLPALVLMLFKVRKG
KSLSELANATAMDPAVLRASVLAANAAARGEAPEPFGKSEGGRQVLEQGPFYACDISVTN
PVFPLGALTLGGLRVDERSGAVLDQQGQAIAGLYAAGRSALGIPSHLYISGLSLADCVFS
GRRAGAAVARPHGQQFETTHAHEMT
>U2FEA8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Haloplasma contractile SSD-17B|TrEMBL
MIMKSILHVYNVEQKECRVLNVFNGHIEAPNWTMDGKNLVYNADGHIFRFDLESLESTQI
NTEDCTSCNNDHVLSFDGKMIAISSGHKESYESRIWTLPLEGGKPTLVTPNAPSYLHGWS
PDGRTLAYCAERNGNFDIYTIPATGGEETRLTTAEGLDDGPEYSPSGDHIWFNSVRSGLM
QIWRMNADGSEQTRMTKDDFNNWFPHISPDGEKVVFISYYKDQVAPGDHPANKDVKIRMM
SANGGDVTTLLDVFGGQGTMNVNSWSPDSKEFAFVTYKLDE
>A0A5S9QXS9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|BD1-7 clade bacterium|TrEMBL
MLKSLIDKIRYREPYQEQHMVIDQPDKFRWDAVTDLAVAGFGGAGAACALEAESQGLRTM
VIDRFQGGGATTISGGIYYAGGGTRIQKEAGIEDSPENMFNYLKREVQGAVSDDTLKQFC
DQSVDNFDWMEANGVPFDASFCPFKTSYPPDHFFFYYSGNESFAPYNKDATPAARGHRGH
RKGISGAAIFEPLRDSVLKKDIDVRTQTKLVSLLTNTDGDVIGLKAIEVKDSFFGKITHR
VLNKLSTLLRYMALYWPPLFNLMGMFSEKVEMASGRSLYVRANKGVVLATGGFYSNQKMV
KEHAPNFAGGSPLGTLADDGSGIKMAIDLGAQTELMDSVSAWRFINPPTSFAKGILVGPS
GKRICNELLYGAQVGERMMRDHDGKAWVILDEATYKQARKDLTLKRALWFHVLLGGMYLW
CGSKKANSIRGLAVKLGVDPEAMADSVKAYNTVAQSDDVDPMXKPKDFMTTIENGPFYAI
DASYDYFYVPCPSLTLGGLKVNEASGAVVTENGDDIKGLYAIGRTAVGIPSRGYVSGLSI
ADCVFSGRRAARHAAENSNTVVDFQQATGT
>A0A853B6Y2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Amycolatopsis endophytica|TrEMBL
MNQTADVIVIGFGAAGACAAIEAADAGADVLVLDRFGGGGATALSGGIVYAGGGTAQQRE
AGVDDSADAMYDYLRLEVGDAVSEETLRRFCDESPAMIEWLERNGVPFEGSLCPYKTSYP
NDDYYLYYSGSESAGGFRDLAKPAARGHRTKGPGTSGKLLFARLAEAVRRRTVRVLPGTR
AESLIVEDGVVTGVRVRTLRNAPRRIRARHARMARYAAKPGIYVPSVRKALQHRIERLER
RYAREEEITARRGVVISAGGFIFNRALVREHAPAYRGGLALGTIADDGSGIGLGTAAGGA
TGEMHRISAWRFVTPPSAMLKGVLVDSGGRRIIDESRYGAAVGEIMIGKHEGKGWLLADA
ETVAEARRTARRESQWFQWLQARYLLRRGRVSADSLDEVARRAGVDADGLKATVEAYNAA
ADSGAADPAGKPAEYVRPVRTAPFSLIDVAIKPSLGFPCPMLTLGGLVVDESTGAVRTSD
GAPIAGLYAAGRSAVGICSESYVSGLSLADCVFSGRRAGISAARRGG
>K1SB78|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|human gut metagenome|TrEMBL
YVSSANYFGELTEWVGFAIASWSWAGAVFAWWTFANLAPRAASLYKRYEKEFGQEFTSLH
RKRIIPFIY
>A0A6J5AHZ2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Paraburkholderia sediminicola|TrEMBL
MQSPSSVPQESATPVETPLVVDDPACVRWDDVCDVLVAGYGAAGACAALEAATAGAKVRI
VERFEGGGASAKSGGVVYAGGGTRYQAEAGYSDTPEAMFAYLQQEVGDAVSAATLKRFCA
GSVDMLRWLERLGVRFAASVPPRKTSYPQNRFYLYYSGNEAVGDAVREHAPAPRGHRVVG
DGMSGRVLYDTLRCAVDAQPFIDTMCHASVRRLITDRSGRVIGAQVWQVAPGRAQRAHRQ
LARWAERLHNGMPAWADRLRAVLHRVEQRDGRLITIKADAVVLSTGGFIFNRSMVAHYAP
RYLPNWRLGTTGCDGSGIRLGLSAGGVAQRLERVSAWRFINPPYAWAQGCVVDHNGERFC
NEEVYGAALGHAMCETRDGHAWLILDARLVKLALKECLRGKLWAFQSVPAMLLMLAGRKR
ARSLADLAARIGSDPAVLERTINAYNLGALNGIDRAFGKSAAMLQPLIYGPYYAIDISSD
SRVFPCPSITLGGLRVDETTNAVLSGQGTPIEGLFAAGRAACGLASNHYVSGLSLADCIW
SGRQAGRAAAGVVLANTAHSLTETD
>A0A1F2PZN3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Rhodococcus erythropolis|TrEMBL
MTWDTSVDVLVVGFGVAGASAALEAVAAGSSVLAIDRALGGGASTISGGIYYAGGGTVIQ
KEAGVEDSPEAMLAYLNREVGDAVTPQTLRRFVDESPASIDWLRSHGVPFEASLCPYKTS
YPSNKHYLYFSGSESAGGFRDIAKPAPRGHRAKGRGTSGKMLYGPLAKSAEAKGVQLLGQ
TRADRLIIEDGRVIGVEVLTLRDAPAGVRRRHATLGSLSSKPGVYAPQLRTILDALIAKI
EKKHAKRIRIQARGGVILSAGGFVSNREMMRTHAPAYKGGIPLGTSGDDGKGINLGIEAG
GATDKLGNVSAWRFIVPPSAFLGSILVGESGARIVDESRYGAALGQAMAEKSNGIGWLLA
DSELVREAKSQISDQSMWFQRVQTTGMMRTAVRGNTIAEVARRAGIDVAGLQATVDAHNS
AAAAGQPDPMGKPSDFVRPILSAPFTMYDVSIKPNMMNPCPMLTLGGLVVDESSGMVKNE
AGEGIPGLYAAGRTAVGICSNSYVSGLSLADCVFSGRRAGQHAAAFSTVGKA
>A0A0D8BH52|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Frankia torreyi|TrEMBL
MDSSEPAHLAEPTHLSEPAHLAEPARLSATAGSETAAGETAAEKAAETAAQKAAETFDVV
VVGFGGAGACAAIAAAERGASVVVLDRFYGGGSTVHSGGVVYAGGGTAQQTQAGVTDTVE
GMYEYLRLEVGDAVSAETLRQFVEGSREMVEWLGRQGVEFEGSLCPYKTSYPTNRHYLYY
SGNELASGYADVAPPAPRGHRTHAKNFSGATFYGRLRDSALRLGVTFRPLAEARGLVVEN
GRVVGVDYDAPPPGRQPGGWHRTYTELAAKAHVWNPALGARLGAVGVAAARRRSVPRRVR
ATGGVVLTTGGHGFNRELVARHAPAWAGLTALGTAGDTGAALDLAATVDAATSHLEKMSG
WRFLSPPSDFMRGIAVNDQGDRFANEQLYGATFSAPLVEEQHARGYLIVDAETWRRARGQ
IRTQSAFFHLPQLAYLFGPAGHRRAATLGELARRVGIDPAGLDKTVREYNDTAAAGLPDR
FGKTGEFHRAIGDGPYYAVDVSARTSSLYPFPFITLGGLVVDGDSGAVLRRDASIVPGLY
AGGRAAVGLCSNSYVSGLSLADAVFSGRRAGAHAAGRAGHFGQAVHSTQSGHSAQAGGHS
SQAGRPGHAVHSRQGELT
>B6ADY3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cryptosporidium muris (strain RN66)|TrEMBL
MSSDNDLNDGPTMRLYIKKRNGKHLAVIDIPKQATVSDLKWQFYNDFHYYPERQWFNIDS
PHGEVLKEGLLSLYGVDNGTSLYFKDLGVQISWRLVFFIEYLGPIIIFPFFYFFPSLIYN
ELAPKKCLAQKLALALTLFHYIKREIETCFIHRFSIATMPIIRLPINCFHYWILFGIGVG
YFVYHPRYIAPQYPPIVFYILTALMCIFEFLNFNSHLVLRKLRDRGTKKRGTPHGWGFNY
ISCANYFWETLAWVSFCFIVNCATCWFYTMVAFGQMTQWALKKHRNYQREFPDYPKTRKA
IIPFIL
>Q99NA0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mus musculus|TrEMBL
MPIVCHQVPVLAGSATLATMGTLILCFGKPASYGKHSESVSSGVPLLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLGLFSAHYFH
>Q8II05|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium falciparum (isolate 3D7)|TrEMBL
MKVILKKRNGKYIDCFDLSPSTTVDQFKEIYYKKYHYYPERQKWNLDSAAGKTLISGTLN
ENGIKDSDILIFKDLGVQISWRLVYVIEYLGPIIIFPFFYFCDKYVYSHTNKNKHIIQIF
SLWFLLFHFIKREFESLFIHRFSNATMPIIRVPINCGHYWILCGVSIGYYLFHPLYKPYD
IESKPYWVYGLFFVLLILEFLNLKCHLILRNLRPRGTKNRGIPHGYGFNHISCANYFYES
LIWIIFSLITNTLTGYVFSFVATTQMTIWALKKHKNYKREFPNYPRNRKAIFPYIL
>A0A5E6X726|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MDSLNGLTALRVNSADQLPWDDRCDLLIVGFGGAGACAAIEASTRGLSVLALDRFEGGGA
TALSGGVVYAGGGTPYQRQAGYEDTSEAMFNYLRQEVGEAVSHATLRNFCDGSREQLAWL
ERQGAAFEASVPPHKTSYPSDQYYLYYSGNEAVPAYAASAKPAPRGHRTKGPGMSGASLF
APLKASALRHGARLRSQCEVRRLVLDLDDKVIGVEAWQLPSGSRAARQHARLSRWAAAIH
MYAPALADRLRARQRRIEQTSAIRQLIRAEQAVLLSSGGFIFNRDLVRQHAPQYLAGLPL
GATGCNGSGIALGQSAGGSVARMDKISAWRFINPPLAWARGLIVNARGQRYANEEIYGAT
LGHAMVEQQDGRAILVLNRELMREALRQVGPGKVWNFQRLPVLLNLLFNAKRSNTLAGLA
KRCNLPPELLHQSVERYSRAARGEVADEFGKSAAMLANLDQGPWYALDLSFDSKLFPCPV
ITLGGLKVCEDSGRVLDHAGQPINGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAAH
VADQFALQTARSGEQQCNV
>K5B8P1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 / 3849)|TrEMBL
MPTVDEYDVIVVGFGAAGASAAIEAADRGARVLVLDRGWGGGATAYSGGIVYAGGGTDEQ
RAGGYRDTVENMRDYLAQEVRDAVRPETLARFCEQSPALIEWLKRQGVPFRGGAAPAYKT
SYPTDRHYLYYSGNEKAYPFREHAEPAPRGHRVVAPGMRSGRELFERLRDSALAKGVRFA
PLARVHDLIQDEDGTVTGVRYTVVDPRHRNARRHKLITKATGKLGTWMPGAVAGAVGYGE
RLLAEAAQPAEARARAVILAAGGFINNREWVRRYAPQFEKISPLGTVGDDGTGIRLGLQA
GGTTDKMGKVTAWRFLSPPSAFLEGLTVGADGRRIASEDLYGATHGDVLMREFGGRGWAI
YDAATWRKIRTQIREQTKMFQRLQIWYLLGPGHRKADTIEALAAKNGIDPAGLRKTVDEY
NRALAAGEGDPAHKDPELCPRLERGPFYSIDISADSSMFYPIPGLTLGGLVVDEDTGEVL
RAEGGVVPGLYAAGRTAVGVCSNGYISGLSIADCVFSGRRAGAHAAGR
>A0A174ASK5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Bacteroides uniformis|TrEMBL
MNQETFQIFLWVMSAVALVVFIALYFVKAGYGMFRTASWGISINNKLAWVLMEAPVFIVM
FGLWGKSGAGFAVPVYFFFLLFQLHYLQRAFIFPFLLKGKSRMPVAIMAMGIVFNLLNGM
MQAGGLFYFAPEGLYADGWAYLLKPHALLGVILFFAGMFINLHSDYVIRHLRKPGDTKHY
LPGKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWTFANLVPRADAIHCHYREEF
GDEAVGKRKRIIPFLY
>A0A086Q5Y2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii MAS|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KVLLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A7W3N479|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Thermomonospora cellulosilytica|TrEMBL
MEPVGLREAGPADHECDVLVVGFGAAGAAAAHEAAGAGADVLVLERAGGPGGTSAQSGGE
LYLGGGTEIQKACGFDDTPDDMYAYLEAALGPHPDTAKLRLYCDESVEHFEWLRARGVPF
KASLYETPTWMPPTDDGLMWLGENAWPFTEIARPAPRGHRPAAPLFAGRVLMDALSSAAT
GAGAVAHRDTQAANLILDDDGRVAGAVARRYGKRVVYRARRAVVLTTGGFVDNDDMLRDH
APVLLGHGKVSDGLDDGSGIRMAAAIGAATRRMGEVEVALAALPVLVARGMLVDALGRRF
INEDVYPGRFSHHAVRHQPGPYWAIIDEEGFDQIPEPDLWGVRPKHAAETLAEMEESLGM
PPGSLANTVEVYNRHAAHGEDPYFHKDPRWLRPLRGPFAAFDPGDGFWGSGGPASGVSGF
TLGGLHTDLDGAVLNHSGARIPGLYAAGRASHGIHGEGYVSGTSLGDGTFFGRRAGRAAA
RDATA
>Q4Q9R2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania major|TrEMBL
MKVIVASGPDGARKHEVELAANATLADLKKAYQPGVDVHRKSFKVPSAESPLPGADSGKL
RPNLITLSDKVPLSQQGVKDGSVITYKDLGPQIGYRTVFYVEYAGPIAFMLLYAMRPSLI
YGSAPMPAYGYTQKLYIGLFLAHFLKRELESMFVHKFSHPTMPMRNIFKNCIYYWSFAAF
IGYVLCSPSFTPTSTMQSNFGAVVMVINELLNFAVHYQLSTMRKSDGDTTRNVPQGPLFA
FVSCPNYFFEIMSWVSFSIGTNMLSSWFFTLAGFVQMADWAKKKHRGYVKADPANKKKAA
ILPFIM
>A0A1S1HJ38|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphingomonas haloaromaticamans|TrEMBL
MAVAAKAQEVGLDVEDPLILDDVSSHAWDEEADLVIAGLGGAGVAAAVEALERGVSVIAV
DRYEGGGSTAANGGIFYAGGGTVIQKEAGEDDSPEEMYKYLKMEAGEVVADSTLRKFVDE
SVSTVDWLLHHGGKLNSAVWKKKASYPPLDRFLYHPDNSLVARYRKVAKPAARGHRAHIA
NGKKAWGVGIGIYNPLRDSALRLGLKFRPLTEARQLAIDASGRVVGLKVLSIPPGSKDAA
AFTKYIRRANHFLAMLPPSIPFAAITIGIGNHYLKKAMRIETHGRETRWIRAREGVLLST
GGFIMNPKMVQRYAPAYAAGMPNGTLGDQGSGIVMGMTAGGSTALMGKVSAWRFINPPKA
WSDAIVVNAKGERFVDETVYGATMGEHIVDHHGGTGWLIYDAAARKQAFRQAFDPVLVPF
QRDVTLLNLLFNYKKAPTLAALADRIGVDRDALATTVARYNRAAAGQEPDPFEKEPEDMQ
PIATGPFYAMDISIASRFLPLPVITFGGLRVEENTGQVLDGEGRPIPGLYAAGRTAVGIA
SQTYVSGLSYADCVFSGRRAARHIAKANI
>A0A5E7S176|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MDSLNGLTALRVNSADQLPWDDRCDLLIVGFGGAGACAAIEASTRGLSVLALDRFEGGGA
TALSGGVVYAGGGTPYQRQAGYEDTSEAMFNYLRQEVGEAVSHETLRNFCDGSREQLAWL
ERQGAAFEASVPPHKTSYPSDQYYLYYSGNEAVPAYAASAKPAPRGHRTKGPGMSGASLF
APLKASALRHGARLRSQCEVRRLVLDLDDKVIGVEAWQLPSGSRAARQHARLSRWAAAIH
MYAPALADRLRARQRRIEQTSAIRQLIRAEQAVLLSSGGFIFNRDLVRQHAPQYLAGLPL
GATGCNGSGIALGQSAGGSVARMDKISAWRFINPPLAWARGLIVNARGQRYANEEIYGAT
LGHAMVEEQDGRAILVLNRELMREALRQVGPGKVWNFQRLPVLLNLLFNAKRSSSLAGLA
KRCNLPPELLRQSVERYSRAARGEVADEFGKSAAMLANLDQGPWYALDLSFDSKLFPCPV
ITLGGLKVCEDSGRVLDHAGQPINGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAAH
VADQFALQTARSGEQQCNV
>A0A5E6S6A9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MDSLNRLTALRVNSADQLPWDERCDLLIVGFGGAGACAAIEASARGLSVLALDRFEGGGA
TALSGGVVYAGGGTPYQRQAGYEDSSEAMFNYLRQEVGEAVSHATLRAFCEGSREQLAWL
ERQGAAFEASVPPHKTSYPSDQYYLYYSGNEAVPAYAASAKPAPRGHRTKGPGMSGASLF
APLKASALRHGARLRSQCEVRRLVLDLDDKVIGVEAWQLPSGSRAAKQHARLSRWAAAIH
MYAPALADRLRARQRRIEQRSAVRQLIRAEQAVLLSSGGFIFNRDLVRQHAPQYLAGLPL
GATGCNGSGIALGQSAGGSVARMDKVSAWRFINPPLAWARGLIVNARGQRYANEEIYGAT
LGHAMVEEQDGRAILILNRALVAEALRQVGPGKVWNFQRLPVLLNLLFNAKRSTSLAGLA
KRSNLPPELLRQTVERYGRAARGEVVDEFGKSAAMLADLDQGPWYALDLSFDSKLFPCPV
ITLGGLKVCEDSGRVLDHAGQPINGLYSAGRNALGVASNLYVSGLSLADCIYSGRRAAAH
VADQFALQTARSGEQQCNV
>A0A7X0L058|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinomadura coerulea|TrEMBL
MAKPSVEPVGAAEVEFDHECDVLVVGFGAAGAAAAYEAAAAGADVLVLERSSGPGGTSAQ
SGGELYLGGGTRVQKACGFDDTPDDMFAFLTAALGPHADAEKLRLYCDGSVEHFEWFRAR
GVPFKESLFDAPGWMPYTDDGLMWLGENAWPYNEIARPAPRGHRPETPMFAGGILMDKLI
AAAAEAGAVAHQDTSATNLVVDGAGRVAGVVARRFADRVVYRARRGVVLTSGGFVDNEEM
LADHAPVLLGHDKVSDGTSDGSGIRMATALGAATRRMASVEIALTANPAVICRGMLVDGL
GRRFINEDVYPGLFSHRAVQHQPGPYWAIIDEAGHDEIDEADMWGVRPKHAAETVAELEG
SLGLPPGSLEATVETYNRFAERGEDPYFHKDPRWLRPLKGPFAAIDPADGFFGAGRHGAG
TGAGGFTLGGLDTTVDGEVRNNSGEPIPGLYAAGRTASGIHGEGYISGTSLGDGTFFGRR
AGRAAASGNREAGG
>F0R666|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Phocaeicola salanitronis (strain DSM 18170 / JCM 13657 / BL78)|TrEMBL
MEQETFHLFLWVMSGIALIVFVALYFVKAGYGIFRTPSWGLSVNNKVGWVLMESPVFIVL
LVLWAYSGIGVAFPQFLFLLLFLLHYFQRSFVFPFLMKGKSRMPVAIMAMGIVFNVLNGM
MQAGGLFYFNEGVPTGIGLGYLLEPHALIGLALFFIGMGINLHSDSVVRNLRKPGDTRHY
LPQRGMYRYVTSANYLGELIEWTGFAVLTASPAAWVFVWWTAANLVPRANAIYHKYCDEF
GAEAVGKRKRIIPYIY
>D6D8N2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Bacteroides xylanisolvens XB1A|TrEMBL
MSIDTFNLFLGVMSLIALFVFIALYFVKAGYGIFRTASWGVAISNKLAWILMEAPVFMVM
CVMWIYSERRFEPVIFTFFLFFQIHYFQRAFIFPLLLKGKSKMPLAIMSMGVLFNLLNGY
MQGKWIFYLAPETMYQSGWFTSPWFIIGTLLFFAGMLLNWQSDYIIRHLRKPGDTRHYLP
QKGMYRYVTSANYFGEIVEWAGWAILTCSLSGLVFLWWTIANLVPRANAIWCRYREEFGD
AVGERKRVFPFLY
>A0A0J6YG13|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycolicibacterium chlorophenolicum|TrEMBL
MLTGTRYDVVVVGFGAAGAAAAIEAADNGARVLVLDRGYGGGATALSGGIVYAGGGTEEQ
HAGGYRDSADNMFAYLRREVGDAVSEATLRRFCEQSPAMIGWLKAHGVPFRGGQVSSYKT
SYPTDSYYLYYSGNEKAHPYADHAQPAPRGHRVVAPGMSSGRVLFERLRASAVSKGVTVL
PLARVHELITDEDGAVIGVRYRAMPLGHPDVRRHSALTKATGKVGNWLPGLVKGVVGRTE
RLWERAAEPGEAYAGAVVLAAGGFIHNREWMRQYAPAFLGISPLGTAGDDGAGIALGVDG
GGYTAKMGNVTAWRFLAPPSAFLEGLSVGVDGRRIANEDLYGATHGDVMMRCFGGAGWVV
YDARTWRKVRAQIGDQTQLFQRLQLLHLLTVGHERATSIEGLAAKNGIDPTGLRRTVDEY
NAGILSGAGDPAHKDPEIAPVLGRGPYYSINISADSSLFYPIPGLTLGGLVVDEDTGAVK
RRAGGVVPGLYAAGRNAVGICSNSYVSGLSIADCLFSGRRAGASAAARMGAISACSSTLS
DEKHAEIATGRLTSVRRPRSRRSTPGSPGRN
>Q4DYN6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma cruzi (strain CL Brener)|TrEMBL
MCRKTHIHMLERHGGNLLSTWTWLLVAVVFLLITTICMVLLQQYVLPLGSATVIESASYF
HLVMAAMTYFTLRFVEVAPFGRHVTSTTAHVTMPAPLSWALQECPTLMNVVYYLLMEYPC
HALRCSSSQWIRLVFDDPFGQAAHAISEGITSLHVGLLLFVIHYLHRTLLYPLIIGEGAP
VPIKITLSAAVYCLLNGRLQLLANIRDGPSAPRFPLLFTSHMALFWIGIVLFFAGMGVNV
LSDNRLVRLKKQPPRHTRKIPHGGLFEYVSCANFFGEIVEWCGYSLVVWSTAATTKPESG
LAAFSFSVYVMANLLPRGYAHHEWYKKQFGAAYDKLRRKAVIPYVY
>A0A446AXB0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas sp. JV241A|TrEMBL
MSSLNGLMPLRVDSAEQLHWHAQAELVVVGFGGAGVCAAIEAASRGLSVLALDRFAGGGA
TALSGGVVYAGGGTPYQQRAGYPDNSEAMFNYLNQEVGEAVSAGTLRDFCERSCEQLVWL
ERHGVAFEASVPPQKTSYPSDRYYLYYSGNEAVPAYAAQASPAPRGHRAKGPGMSGASLF
APLRASALKLGVRLRSQCEVRQLVLDNHDRVVGVVAWQLPADSRAARRHARLARWASAIH
MYAPALADMLRKRLRQIEQRHAVRTLIRAEKGLLLSCGGFIFNRALVARHAPQYLAGLPL
GTTACDGSGLLLGQSAGGTLARMDKVSAWRFINPPLAWARGMIVNGFGQRYCNEEVYGAT
LGHAMVEEQNGKAILILNRALVRQALKQVGPGKVWNFQRLPVLLNLLFNAKRGNSLELLA
ERCGLPVGNLRQSVAQYSRAARGEIADPLGKSAAMLCPLDSGPWYALDLSYDSRLFPCPA
LTLGGLRVDEGSGAVLDLHGTPIAGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAAH
IAARTAPNPAPSGEQPCNV
>Q4QE81|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania major|TrEMBL
MSADARIAIIAVVHLALTWVLLRYIADSAMPFYVYREDSSSAGAAHGASVHTAATHEWDL
WPPFLVPSQEAYVAQLARQQRATSAADAVALNSRVVWRSSAFHLTLAIFTYALLRFGVTA
PYGRHSWSLGFQLTLPSRVSWMLQESPTIFQVLYHAFLEYPRLMGHSPSQPSLWPASSSA
SGPTGAGMPSSHSSADTCHSYWGCVRVACTQQHLGLLLFVIHYVHRSWLYPLSIPATARD
VPLVVTGMATLYCLFNGRLQVLASAGAAATACAADTAARSSACTPAYTASMNLVRCWRER
HALQSLSSPSSASTSVGAAAVRVGWWLLLGLYALGVLGGSALFFLGQRINMQADYYLVRL
RRGDKGSISHGGIKPVGRRAVNVHGDALASSSSSEASRAAQHRSSVDGYRIPVGGWFDSV
SCANFFGELVEWTGYVIVVAATSAASNGSCLSVTTALEEELLRPLSSSSWWSLMNPIMWL
RLVARVFFSGSESRPAALAAFSFLVYVFSNLAPRAVAHHAWYARTFGDLYTRLGRQALIP
GVY
>A0A7W8Z0F0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphaerisporangium krabiense|TrEMBL
MSTASTAPVPVSRVHHWAAEADVLVAGNGCAGASASIEAVAAGAEVLVVDAAGGWGGATA
MSGGEIYLGGGTSVQKACGFEDSVDAMYAFLKLATGPDPAEDKLAVYCEGSLEHFDWLVR
CGVTFVPKLWTEPSWEAPTGYGLMYTGGENAYPFAGLVPPAPRGHIVHMEDKLPGERSAG
WMLIKNLTATQERAGVEVRYNTRAERLVVDGERVVGAEVVTFGERYFVRARRGVVLAAGG
FAANPAMLSQHAPRLATGTFLVGTDNDDGRGIRMGQAVGAAVRHMDAGLAAFPADPALLY
RSLLLNGRGHRFINEDTYPGRVGQATVFQQDRKAFLLYDETTNEEAARLAEHVVQPTWVS
DDLGELEKEMGIAPGVLAGTVAVYNAGAERGEDPEWHKAAQWLRPLEPPYGVLDLREAPY
GVFTIGGLHTSTRGEVLNAEGDPIPGLFAAGRTTSGIPSWGYCSGTSLGDSTFFGRRAGR
AVATA
>A0A6J5FXC9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Paraburkholderia caffeinitolerans|TrEMBL
MNARAAHAMNDANTHAQAGASATPVEPPLVVADVRAHRWDDACGVLIAGFGAAGACAALE
AAQAGARVRIVERFEGGGASAKSGGVVYAGGGTTYQREAGYADTPEAMAAYLQGEVGDAV
SPDALERFCNGSVAQLAWLERQGVRFGSTMPARKTSYPPEHAYLYYSGNEAVGDAPAVPP
APRGHRTKGRGMSGRVLFDTLRRAVQAEPNVEILRHAGVRRLIVDTTGRVIGAQVWRVEP
GRAQRQHARLARWADKLHNGLPALADRLRAALLRLELRASRALDIRADAVVLATGGFIFN
HEMLAQHAPRYLANWRLGTTGCDGSGIRLGVSAGGVADRMERVSAWRFINPPFAWARGCV
VDARGERFCNEEVYGATLGHAMCETRDGRAWLILDAALVREALRECVRGRLWAFQSVPAL
MLMLGGRKRAATVAQLAEQIGADAATLERSLAAYRAAARQGRDAGFGKSAAMLAPLAQAP
FYALDISAASRAFPCPAITLGGLRVDETTNAVLRAKGGAVEGLYAVGRAARGLASNHYVS
GLSLADCIWSGRQAGRAAARETQAARERIFNDQDAERKASAIKTASAKVIPLYPLTH
>A0A5E7HXS7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATIDDSFYTPIQTPLQVADSSALLWDERCDVLIIGWGAAGACSALEARALGADVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVISDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPQHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKDACLRAGARPLLQAAAKRLVVDAQGRVLGAEMWCITPGTPQAELHARLA
ARAERLQNFAAGYCNKLRQRIGQLERDFARPRLVHARNGVILSTGGFIFNRELIKRHAPK
FLRNFKVGATGCDGSGLRLGTSVGGQGAGLERVSAWRFLNPPYSWHKGIVVNREGRRFCN
EEVYGATLGHPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSLPALVLMLFKVRKG
KSLSELANATAMDPAVLRASVLAANAAARGEAPEPFGKSPGGRQVLDQGPFYACDISVTN
PVFPLGALTLGGLRVDEGNGAVLDGQGQAIPGLYAAGRTALGIPSHLYISGLSLADCVFS
GRRAGAAAARFMDQQLQPTLAQETT
>B0EHD0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Entamoeba dispar (strain ATCC PRA-260 / SAW760)|TrEMBL
MVKILYKGNTHTVEIELTKQVRELRFNIEIVTGLKACRQRLWYQKGEEKIVLEVDKTLQE
SGITEDTLIEMKDLGPQLPFRFVYICEYIGPLALYVLIYLISLFTGYPNLLQNKLAVIMW
VIHYIKRIIETIYVHEFGDMTMPVFNLYKNCTYYYGFAIAVGINVNFFARENCSFLIIIG
LIGMIISIISNGYCHLLLKQLRTPGSQEWKMPHGFLFEYITCANYFCEIMTWIFFNIMTG
FSLFGIAFSCCGIYQMREWAYQRHQKYLHIFPDYPKRWILIPFIY
>A0A1I9YXX7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardia seriolae|TrEMBL
MAETPTVTPLPAHTVETWDYEADVVVVGFGIAGVCAAIEASRAGADVLVLERTGGWGGAA
AMSGGFIYLGGGTALQRKLGFEDTPEHMEAFLTAALGPGVDKAKIHDYCQGSVDHFDWLV
AQGVPFKEEFWGEPGYEPPADQGLMFSGGENAAPFKDEIPPAPRGHLAWTKDKKLGEKGG
GYMLMEPLAQKAEELGVRHEYDIRLRRLITDDEGRVVGVAATRYGKPVHVRATRGVVLAT
GSFAYNHEMVERFAPKISGRPAATVEEHDGIGIRVAQALGADLAHMDATEVALVVDPQLV
ARGILINGRGQRFITEDTYPGRMGQAVLLEQGNQAYLVIDEIALEEALETKSSMSFLRIA
PTWVAETVAELEDEMGLPENTLQATIDLYNHHAEKSEDPFLDKKPEWVKPIRTPLGAYDL
RGYTGGFTLGGLRTDLDSRVLHVSGNPIPGLYAAGRVTSGICAGGYASGCSLGDGSFYGR
RAGVSAAKQL
>A0A077TMP2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium chabaudi chabaudi|TrEMBL
MKVILRKRNGKFIDCFDISPSTTVDKFKELFYIKYHYYPERQKWNLDNATGKTLVSGTLS
EIGIKDGDILIFKDLGVQISWRLVYVIEYLGPILIFPFFYFCDKYIYSHSAKNKHIIQIL
SLWFLLFHFLKREFESLFVHRFSNATMPIMRVPINCGHYWILCGVNIGYYLFHPKYKPYN
LGSKPHLVYYIFFVLLVLEFLNLKCHLILKNLRPRGTKTRGIPYGYGFNYISCANYFYES
LIWIIFSLITNTLTGYIFCCVAITQMAIWALKKHNSYKKEFPHYPKNRKAIFPFVL
>A0A1J1GZG3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium gallinaceum|TrEMBL
MKVILKKRNGKFIDCFDLSPSTTVEEFKEIFYKKYHYYPERQKWNLDSAAGKTLKSGTFE
ENGIKDSDILIFKDLGVQISWRLVYVIEYLGPILIFPFFYFCDKYIYSYSNKNKNIIQIL
SLWFLLFHFIKREFESLFVHRFSNATMPIIRVPINCGHYWVLCGVNIGYYLFHPLYKPHD
IVSKPFLVYSLFFVLLILEFLNLKCHLILRNLRPRGTKNRGIPHGYGFKYISCANYFYEV
LIWAIFSIITNTLTGYIFTIVATTQMAIWAIKKHKNYKREFPNYPKSRKAIFPFIL
>A0A2S8BQS5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium talmoniae|TrEMBL
MIRATSEVSTATTDVVVVGFGAAGTSAAITAREQGAEVIALDRANGGGATAISGGIIYAG
AGTSVQRQAGVADTVDQMLAYLRLEVGDAVSPQTLERFVRTSPEMIDWLQRHGVPFDASL
CPYKTSFPNNRYYLYHSGSENAGAFSSRTPPVQRGHRVKGKGTSGKQLYAPLARSARALG
VDFRPHTKVTALLQDSSGRVTGVEARTMQHAPRHIRRAYAAMAALSTKPGVYYPPLRQAM
DRRLAALERRYARPVRIVARQGVIVCAGGFIANTDWRERHAPDFVHGLPLGTSGDDGSGI
ALAQDMGAVTAHMDNVSAWRFITPPSAFLSSIVVDDKGQRIIDESRYGAALGRAMVTNHG
GKGWILADANLMAQAKRQLLTQTLWFQRAQAAALMFADAVHGPTLADVARGAGVDPEAWR
RPSKRTMPPSTRGQRIPSASRRTFAAASSGGRSP
>A0A0D2JS53|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Monoraphidium neglectum|TrEMBL
MVALMSGISAPYGRYSTGGWGFLINAKVAWVTQELGSFAVPTVWLALFATPDQLARARAP
ANALLLGLFLLHYLNRCFVYPLRLRGGKPTPFVVWLLAAVFTAYNGFMQAKYFLTEAPAG
APITPLVVAGALVWAVGWLVNLHSDEVLLNLRRPGETGYKIPRGGAFELVSAANYFGEIL
EWAGWALAARSAPAAAFSFFVLANLGPRAWHHHLW
>A4H965|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania braziliensis|TrEMBL
MPTAMRTAIIAVVHLALTWVLLGYIADSAMPFYAYCAGGNDTAAAVSGTFVFAAATHDWG
QWPLFLRSNQEAYMAQLAQHQCAMSASDAATLNSRVVQRSSVFHLTLAIITYVLLRFVVT
APYGRHAEGLGLRLTLPSRLSWMLQESPAILQVLYHVLLEYPRVMGHGFSLSSKWSLSSS
TPGWIVAGVAGRDSSVDTCQSYWGCVWTACTQQHLGLLLFSIHYVHRSWCYPLSIPASAH
GVPLALTWMATLYCLFNGRLQVLASAGAAVAACPTGTATWSSACAPAYTPSMSFVRCWRK
RHELQSSFSASSVGAAAVHIAWWFLLFLYTVGVFGGSALFFAGQRINMQADYYLIALRRR
GEDNISDDRSKPVGQSAASLDGDVLVSSSSGASRAAQQRSRGGGYRIPVSGWFDCVSCAN
FFGELVEWTGYVIVVSATSAASNGSCHSVATALEDELLRPLSSSSWWSLMNPMMWLRLVM
RVFCSGAESHPAALAAFSFLVYVFSNLAPRAVAHHAWYAKTFGDRYTRLGRKALLPGVY
>A0A7W4VF89|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cupriavidus alkaliphilus|TrEMBL
MAQDAVTPVHAPLRLDDPDAHSWQAACDAVVVGFGAAGACAALEAAHGGARVIVAERFEG
GGASTRSGGVVYAGGGTPYQRAAGYDDTPQAMAGYLRQETGGVVSDATLQDFCENSRAML
GWLEALGVRFAATVPPRKTSYPAQPYYLYYSGNEAVPAYAQHAAPAPRGHRVKGPGMSGR
TLYGVLRRAVEDNRQITVMRQCAARRLIVDRDGAVVGVELWQLPPGRHQKRHARLARLAE
RLHNAMPALADRLRAQVLQLELRHAQPVAVRTGAVVLATGGFIFNRAMVARHAGKYQQAW
RLGATGCDGSGIRLGESAGGATRHLGRVSAWRFINPPFAWARGCVVDAHGARIGNEETYG
ATLGHAICERHGGRAWLVLNRALAREALRECLGGRLWAFQALPAALLMLAGARRAASIEA
LAGKLGMPGPALRVTLDAYNAAARGERPDPAGKSAAMCASLETGPWLAIDISAGSRVFPC
PAITLGGLAVEESSGRVLAAASGAPIPGLYAVGRTAVGIASNHYVSGLSLADCIWSGRNA
GRHLAQQPAGHLIGGKQAHTHQETTHEPTY
>K1SXL6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|human gut metagenome|TrEMBL
MEHAFDIFLTVMALLALAVFIALHFFEAGYGYLFNRRYGPPVPNRIGWMVMESPVFILMC
VLWATSDRMLQAGPLALFLLFQAHYFQRAFIFPLLIRGNSKMPLGIVLMGMVFNTLNALM
QGGWIFYVSPANYYDNWFAQPYIYIGGVLFLAGMAINLHSDWIIRHLRQPGDTRHYIPRG
GMFRYVSSANYFGELLEWVGFAVASWSWAGAVFAWWTFANLAPRAASLRRRYEREFGESF
QTPTQTHHTFI
>A0A8H2NXW4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MNGVNGLTALRVNSADQLPWDDRCDLLIVGFGGAGACAAIEASARGLSVLALDRFEGGGA
TALSGGVVYAGGGTPYQRQAGYEDSSEAMFNYLRQEVGEAVSGETLKHFCDGSREQLAWL
ERQGAAFEASVPPHKTSYPSDQYYLYYSGNEAVPAYAASAKPAPRGHRTKGPGMSGASLF
APLKASALRHGARLRSQCEVRRLVLDLDDKVIGVEAWQLPSGSRAAKQHARLSRWAAAIH
MYAPALADRLRARQRRIEQTSAIRQLIRAEQAVLLSSGGFIFNRDLVRQHAPQYLAGLPL
GATGCNGSGIALGQSAGGSVARMDKVSAWRFINPPLAWARGLIVNARGQRYANEEIYGAT
LGHAMVEEQDGRAILILNRALVREALSQVGPGKVWNFQRLPVLLNLLFNAKRSNSLAGLA
KRCNLPPELLRQSVERYSRAARGEVADEFGKSAAMLTNLDQGPWYALDLSFDSKLFPCPV
ITLGGLKVCEDSGRVLDHAGQPINGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAAH
VADQIALQTARSGEQQCNV
>B0EV92|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Entamoeba dispar (strain ATCC PRA-260 / SAW760)|TrEMBL
MVKIIFNSQHYSLPISLNKTVREMKVEIEKLCKIKPCQQRIWYYTKENKKVILLVDKTLT
ECGVNEETELEMKDLGRQLPYRFVYLLEYIGPLVLYFIPFFILKALNRIILYQQYMALFL
WVIHYLKRIFETIYVHEFGDNTMPYNNVFKNCTYYWGFALAVSINVNLFSRQVPDMFVSI
CACAMIISIISNSYCHLLLKWLRPPGTQIRAIPKGFLFEYVSCPHYFCEIMTWIFFNALT
GFPFFGVLFSLCGIYQMREWALQKHQRYYREFPDYPKNRTVLIPFLY
>A0A086PJR6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii VAND|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A7W9NK08|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Kutzneria kofuensis|TrEMBL
MLAGVVVVGFGAAGACAAIEAADAGADVIVLDRFDGGGATALSGGVVYAGGGTAQQAKAG
IADTPDAMYDYLAHEVGDAVTPQTLRDFCDGSPDMLAWLEDKGVPFASSVCPYKTSYPTD
RHYLYYSGSETLFDRPAPRGHRTAGRGTSGKLLFQRLERAAIDRGVRILRRTTAQRLITD
PNGRVVGVQCRQLTGFPARVHRFLGKLAAKPGLYVLSLRRRLHRSIRRIESRHGTEITVS
ARDGVILCAGGFVANPVMMREHAPAYRRGLPLGTLGDDGSGIRLGADIGAATAKLDHVSA
WRFVTPPSALMKGKLINQQGEEICDLNRYGAAVGHAMITEHGGKGWLLVDGATLAEAKRQ
IPWQTTWFQRLQTRYLFGRARTTAHSLDELARRTGVTIKDFEGQAPFSLIDVSIKRSIGY
PCPMLTLGGLVVDENTGEALSADGTAIPGLYAAGRNAVGICSNSYVSGLSLADCVYSGRR
AGRHVAAVRRSGAQR
>A0A653HNE0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Hepatocystis sp. ex Piliocolobus tephrosceles|TrEMBL
MKVILKKRNGKFIDSFDLSPSTTVEQFKEMYYKKYHYYPERQKWNIDSAAGRVLISGTFN
ENGVKDNEVLVFKDLGVQISWRLVYVIEYLGPIFIFPFFYFCDKYIYSHTNKNKNIIQML
SLWFLLFHFIKREFESLFVHRFSNATMPLIRVPINCGHYWVLCGVNIGYYLFHPLYKPLN
LGSKSYIIYALFVILIILELLNLKCHLILRNLRPRGTKNRGVPHGYGFNYISCANYFYES
LIWIIFSLVTNTLTGYIFSIVAIVQMTIWAIKKHKNYKREFPNYPQSRKAIFPFIL
>A0A2G8Y252|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii COUG|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQ
VAVEDQQERETKASFVRNCADGMLNALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRR
CRLSLPEKNDTPVSALLSNASPDSIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLP
LLLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQP
LPSCSANACPLSLEASPALFAASIQHVGEALVARATSRPGSVGMTFAAFLLVNCMQLHSH
MLLARLRLADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILI
YLCLCLLLPSPPTIACLSFVVATMTVNASKTHTWYRRTFGDAYPQYVFSL
>A0A384LMM5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium knowlesi (strain H)|TrEMBL
MKVILKKRNGKFIDCFDISPSTTIDQFKEIYYKKYHYYPERQKWNLDSAAGKTLKSGTFH
ENGIKDSDILIFKDLGVQISWRLVYVIEYLGPIFIFPFFYFCDKYVYPQANKNKHIIQIL
SLWFLLFHFLKREFESMFVHRFSNATMPIRRVPINCGHYWVLCGVNIGYYLFHPLYKPYN
LETKPVIVYSFFCVLLILEFLNLKCHLILRNLRPRGTKSRGIPHGYGFNYISCANYFYES
LIWIIFALIINTLTGYLFSIVATTQMAIWALKKHNNYKREFPNYPKNRKAIFPFIL
>A0A839QDP4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycolicibacterium iranicum|TrEMBL
MTRDIVPIAEAEISRWDHEADVVIAGYGVAGASAAVEAARAGADVLVLERTGSWGGAASM
AGGFIYLGGGTPLQKACGFEDSVDNMAAFLKAAMGPGADDKRIDDYCAGSVAHFDWLVDC
GVTFKEEFYGEPGWEPMGDQGLMYSGGENSFPFNTIATPAPRGHVPQMSNKKQGEASAGY
MLMKPLVETATAAGARAVYDVRAQRLVVSADGRVTGVVARRYGGEVTIRARRGVVLATGS
FAYNEAMVAQYAPRIAGRPAASIEQHDGRAIQMAQALGADLAHMDATEVAIFADPQQVVR
GILVNARGQRYVAEDTYPGRIGQLTLYHQDNTAYLIIDADAQEEAVASLSPQLMMRPPTW
VGDTVAELESEIGLPPGSLQATVAAYNEGAARGEDPLLHKKPQWITPIGSPVGAIDLRES
TGGFTLGGLATTLDAEVLHVSGEAIPGLFAAGRSAAGLAAWGYASGVSLGDGSFYGRRAG
AGAARA
>A0A3R8AWY5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii CAST|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQEREIKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLPEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSRPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPTIACLSFVVATMTVNASKTHTWYRRTFGDAYPQNRRALLPLVY
>A0A086KFW9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii GAB2-2007-GAL-DOM2|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQERETKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLAEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPT
>A0A125YRT7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii (strain ATCC 50611 / Me49)|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A231H2X6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardia cerradoensis|TrEMBL
MSEQGPATTPEQVYDVVVVGFGGAGACAAIAAAEAGASVLVVDRFYGGGSTTHSGGVVYA
GGGTPAQREAGVTDTAEAMFTYLAQEAGDAVGTATLRRFVDGSPGMIEWLTRQGVPFEGS
LCPYKTSYPTNRHFLYYSGNEQVPSYADNAAPAPRGHRVRAKNFSGAAFYATLRDAALGK
GIEFRPLAEVRELIVANGAVVGVEFDAPDPGVFGRRHKIRTEIAAKAEVWHPPLGDRLMA
KVVSAQRKRSTRHRVLARGGVVLCTGGFGQNKELVRRHAPAWTEVSPLAAGGDDGAGLRL
GAQVDAATSHLHKMSGWKFISPPSGFLEGVAVGMEGDRFANEQLYGATMSEPLIEQQGGR
GFLILDAAGWRTARRQAREQSAFFQVPQSLYIFSPFGHRRAATVQALASACGIDPAGLAA
TVAKYNQDIEAGRPDRFGKADQYRRVLDRGPYFAVNLAPGVSPAYPFPFITLGGLAVDED
TGAVRRATGGTVPGLYAAGRAAVGICSNSYVSGLSLADAVFSGRRAGEHAARSGRDVEIL
ESKNQETR
>A0A7W7ABF6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Novosphingobium taihuense|TrEMBL
MEQARGKAGPLHPESVWRTSTCTALPPPGSPIRSWGLAIDAPLRLGDADAHDWAGEADVV
IVGLGGAGVSAALEALEQGLSVIALDHYDGGGSSAANGGVYYAGGGTSIQREAGVEDDAE
RMEAYLHTEVGDVVPEHALKDFCERSAETFEWLRSHGAPFSATLYGKKTSYPPLDRFLYH
PDSSLAEPFRSHTPPAARGHRTVRRNGNKPWGLGAGIWEPLRDAALARGLQLHTQAEARQ
LALDETGRVIGVRVEMFRDPAIRAKHSRLVGKANAWMAMLPPTFPGARLTYARGFKFLAK
ARALEKTSRSSAWFRARKGVVLSAGGFICNPEMVRHFAAPYAAGLPNGTLGDNGSGIMLG
VTAGAATGLMERVSAWRFLSPPASWGRGMLVDGTGVRYVNETWYGARIGDAMVERHGGLG
WIVLDRKLFRQSLRDAFAPETLAFQRDITLVNALFAAVKAGSPAALAAKLGFDPAVFSQT
LETYNRAARGEITDPLYKTEADLAVLDEGPFYAIDASVDARMFPIACMTVGGLLVDERTG
AVKALDGGRVEGLYAAGRNAVGICSNLYVSGLSYADCVWSGRRAARALAALELKPGSTQV
EGE
>A0A498QKN9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium pseudokansasii|TrEMBL
MAGDKSARIGESADVVVIGFGAAGECAAIAARERGADVIALDRANGGGATAISGGIIYAG
GGTIVQQQAGVNDSPEQMLAYLRLEVGDAVSQETLESFVRSSPEMIDWLSSYGVPFSPAV
CPYKTSFPNNRYYLYHSGSENAGAFRCHTPPVQRGHRVQGRGTSGRKLHEPLAKAAVALG
VRFWPRTTVTNLIQDSSGRVTGVDALTMHFAPPLIQRRYAAAAKLSAKPGIYYPPLRRLI
EGQLRRLERRYAQPVRIHARRAVIICAGGFIANTDWVQRFAPQYVGGLQLGTSGDDGSGI
ALAQSVGAVTDRMDNVSAWRFITPPSAFIGAVIVDRGGHRVIDESRYGAAVGQAMIRQHE
GAGWLLADAALMREARRQMITQPLWFQRAQVAALMLADAVTAPSLPEVAKAAGIDPDGLV
ATVAAHNAAIDTGAPDPAGKPAEFVRRISQAPFTLLNISVRPSLLNPTPMLTLGGIRVDE
RSGAVVNESGEPIPGLFSAGRTAAGVCSNSYVSGLSLADCVFSGRRAGTHAAAASAEQSP
R
>A0A086M5I4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii RUB|TrEMBL
MNSLPSALAFGVILSLAIPAVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREESRREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQD
AVEDQQERETKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLPEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSRPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPT
>A0A7W9PC52|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardia transvalensis|TrEMBL
MTETPTVRPAHAATITAWDLEADVVIAGYGVAGASAAIEAARAGADVLVLERAGGWGGAA
SQAGGFIYLGGGTPLQKALGFEDTPENMEKFMVAALGPGVDKAKIHDYCQGSLEHFDWLV
AQGVPFKEEFWGEPGWEPPHDEGLMYSGGENAAPFLDLVPPAPRGHVPRMENKRTGAKGG
GFMLMKPLTDTAESLGVRAEYDLRIQRLVVDEEDRVVGIVAKRYGKELTVRARRGVVLAT
GSFAYQQQMIESYAPRLIGRPGAAIEEHDGIGIRISQALGADLAHMDATEVAFFGDPQRM
VRGILVNGRGQRYIAEDTYPGRIGQATLLQQDNQAYLILDEESLEAADATETSTPFFRQP
PTWVAESVEELEGEMGLPAGSLQTTVEVYNRHAKDGVDPLLGKKPEWVRPIGAPLAGYDL
RGMTAGFTLGGLRTDLDSRVLHVSGEPIAGLYAAGRCTSGICAGGYASGASLGDGSFYGR
RAGRAAATGDTPHASAAAN
>A0A839QC99|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycolicibacterium iranicum|TrEMBL
MPTGFEYDVIVVGFGAAGAAAAIEAADRGARVLVLDRGYGGGATAYSGGIIYAGAGTAEQ
QAGGYPDSAQNMQAYLTQEVAGAVSAETLTRFCEQSPAMIDWLKAQGVEFRGGQVPEYKT
SYPTDSHYLYFSGNEKAYPYSAHAQPAPRGHRVLAPGMSSGRVLFERLRDSALAKGVDFI
PLAQVHSLVQADDGRVTGVRYRVLDPAHRSARQHRTVAKATGKLGTWMPGLIEGVVNRAE
RLRARHSIDTHARAGAVILAAGGFVHNRQWMSAYAPDFLKISPLGTAGDDGTGIQLGLDA
GGVTDKMGNVTAWRFLSPPSAFLEGLTVGANGRRIANEDLYGATHGDVLMRDFGGTGWAI
YDAATWRKIRTQIKDQTQIFQRLQLWYLLTIGHKKAATVEGIAAKNGIDAVGLRHTIDAY
NRGIGSGTGDPGHKDAALCRPMERGPFYSINISAGSSMFYPIPGLTLGGLVVDENTGAVV
HRDGGTVTGLYAAGRNAVGVCSNGYVSGLSISDCVFSGRRAGADAALATGADPDFRRTPG
RA
>A0A173Y6N4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Bacteroides finegoldii|TrEMBL
MCGYYFHFCYFCALQKNFNMNLAAFNLFLGVMSLIALIVFVALYFVKAGYGIFRTSSWGA
AISNKLAWILMEAPVFLVMCVMWMYSERRFEPVILTFFLFFQLHYFQRAFIFPLLLKGKS
KMPLAIMSMGILFNLLNGYMQGEWIFYLAPATMYQSDWFTSPYFIIGTLLFFMGMLVNWS
SDYIIRHLRKPGDTRHYLPQKGMYRYVTSANYFGEIVEWAGWAILTCSLSGLVFLWWTIA
NLVPRADAIWKRYREEFGDAVGTRKRVFPFLY
>G0ACA3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Collimonas fungivorans (strain Ter331)|TrEMBL
MQLTPRLAIFTIAASLAYLWLAILGEGGFSAFFSRPALSVTAAALIVMAGAALFTGANLS
SGEREDRGNRWIIPTVGLIGLLQAYLPAYSDRIGFWTFGGDALRWAGVVLFIAGGALRLG
PVFILGRRFSGLVAIQPGHELVTDGIYGVIRHPSYLGLLVNSLGWSLVFRSGLGVLLTLL
MIPPLLARMRAEEALLHSQFGAAYEAYRSRTSRLIPGIY
>A0A1G4II38|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma equiperdum|TrEMBL
MKVTVISGSSSEVVELPSNAGLTDLKKVYKPRVDIHRKSFKILRSGGDKNDKSAYITLDA
KRALTEQGVKDGSEVVYKDLGPQVGYRTVFVVEYAGPLAIMLAYAARPSFIYGSSIVKEY
CYTQKLYIALFCAHFIKRELETFFVHKFSHPTMPRRNIIKNCVYYWTFALGIGYALCSPY
YTEPASPTLVNASAVAMVIFELLNFAVHVQLSGMRKGDGDATRPVPKGILFSLVSCPNYL
FEILSWVAFSLGTSMLTSWGFTFAGLVQMAEWAVKKHKNYIKTDPSVRNKKAMLPFLL
>A0A7Y9GHD2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinomadura citrea|TrEMBL
MAKPSVEPVGAAEAEPDHECDVLVVGFGAAGAAAAYEAAVAGADVLVLERSSGPGGTSAQ
SGGELYLGGGTRVQKACGFDDTPDDMFAFLAAALGPHADAEKLRLYCDGSVEHFEWFRAR
GVPFKESLFDAPGWMPYTDDGLMWLGENAWPYNEIARPAPRGHRPETPMFAGGILMEKLI
AAAAEAGAVAHQDTCATNLVVDGAGRVTGVVARRFADRVVYRARRGVILTSGGFVDNEEM
LADHAPVLLGHDKVSDGTSDGSGIRMATALGAATRRMATVEIALTANPAVICRGMLVDGL
GRRFINEDVYPGLFSHQAVQHQPGPYWAIIDEAGHDEIPEADMWGVRPKHAAETLAELEE
SLGLPPGSLEATVETYNRFAERGEDPYFRKDRKWLRPLKGPFAAIDPADGFFGAGKHGAG
TGAGGFTLGGLDTTVDGEVRNNSGEPIPGLYAAGRTASGIHGEGYVSGTSLGDGTFFGRR
AGRAAAAN
>A0A7K0D6S3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardia macrotermitis|TrEMBL
MVWDATTDVLVVGFGAAGACAGLEARAAGAEVLAVDRFNGGGATELSGGIVYAGGGTVIQ
REAGIGDTSEAMLAYLTREVGDAVRPETLRRFVDSSPEMIEWLMGHGVPFEASVCPYKTS
YPDNRYYLYYSGSECSGEFRAVTPPVQRGHRAKGKGASGKKIYQPLARAAMRAGVEFRPH
TRVVALESDEDGRVIGVRARTMAGAPPSIRRRFAAMAAIAAKPGIYYPPLRRILEGRLDA
LESRYARVVRIRARRGVILCAGGYIANRELLARHAPGYTGGLALGTTGDDGSGIELGVAA
GGVAERMDNVSAWRFIAPPSAFYGGLLVNEQGQRFIDETRYGAAVGNALVREQGGKGWLF
VDAETMRRARGQLSDEAIWFQRLQAESLLRTSAISADTVAEVARRAGILPDGLTATIRAH
NDAISTGAPDPMGKPADFTHPIGPGPYTLLDVSVRPKLTNPCPMFTLGGLAVDEDTGAVK
SAAGEPIPGLYAAGRSAIGICSESYVSGLSIADCVFSGRRAARSASARLVEAVD
>A0A380SWB2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas wadenswilerensis|TrEMBL
MSSLNGLMPLRVDSAEQLHWHAQAELVVVGFGGAGVCAAIEAASRGLSVLALDRFAGGGA
TALSGGVVYAGGGTPYQQRAGYPDNSEAMFNYLNQEVGEAVSAGTLRDFCERSCEQLAWL
ERHGVAFEASVPPQKTSYPSDRYYLYYSGNEAVPAYAAQASPAPRGHRAKGPGMSGASLF
APLRASALKLGVRLRSQCEVRQLVLDNHDRVVGVVAWQLPADSRAARRHARLARWASAIH
MYAPALADMLRKRLRQIEQRHAVRTLIRAEKGLLLSCGGFIFNRALVARHAPQYLAGLPL
GTTACDGSGLLLGQSAGGTLARMDKVSAWRFINPPLAWARGMIVNGFGQRYCNEEVYGAT
LGHAMVEEQNGKAILILNRALVRQALKQVGPGKVWNFQRLPVLLNLLFNAKRGNSLELLA
ERCGLPVGNLRQSVAQYSRAARGEIADPLGKSAAMLCPLDSGPWYALDLSYDSRLFPCPA
LTLGGLRVDEGSGAVLDLHGTPIAGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAAH
IAARTAPNPAPSGEQPCNV
>A0A5K1VAC6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium knowlesi (strain H)|TrEMBL
MKVILKKRNGKFIDCFDISPSTTIDQFKEIYYKKYHYYPERQKWNLDSAAGKTLKSGTFH
ENGIKDSDILIFKDLGVQISWRLVYVIEYLGPIFIFPFFYFCDKYVYPQANKNKHIIQIL
SLWFLLFHFLKREFESMFVHRFSNATMPIRRVPINCGHYWVLCGVNIGYYLFHPLYKPYN
LETKPVIVYSFFCVLLILEFLNLKCHLILRNLRPRGTKSRGIPHGYGFNYISCANYFYES
LIWIIFALIINTLTGYLFSIVATTQMAIWALKKHNNYKREFPNYPKNRKAIFPFIL
>S7WC50|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii (strain ATCC 50853 / GT1)|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQERETKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLAEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPTIACLSFVVATMTVNASKTHTWYRRTFGDAYPQNRRALLPLVY
>A0A086K1Z7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii FOU|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A173KUX2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphingobium sp. EP60837|TrEMBL
MDYTEKTAATHLPVDPWHLRPPAPVPLAGQPISQWGLAIDAPLRLDDPERHAWDDEADMI
VVGLGGAGVAAALDGLGRGLSVIALDLYEGGGSTAANGGVYYAGGGTSIQQEAGVEDDPA
SMEEYLRFEVGNVVSAETLRDFCQSSAETFEWLRQHGAPFSATLYAKKTSYPPLDKFLYH
PDSSLAGPFRDLTRPAARGHRTVHRNGKNPFGLGVGIYAPLKAAALARGLKFHTHSDVRQ
VAVDADGRVIGVRAERLADPVVRERHSRLIAKANKWMTMLPSTLPGAQLTVAIGYRYLAK
AEALAADARTSLWLRARKGVVLSAGGFICNPEMVRHFAPHCSAGLPNGTLGDNGSGIMLG
VSAGGQTGLMERVSGWRFLSPPHAWGRAMVVDGEGRRYLNETWYGARIGDEMLERHDGRA
YIIMDRKLWRQALKDAFGEGVLSFQRDITLVNCLVGATKAATPADLAAKMGFSREVFASS
LDKYNRAARGDIADPFHKAPDEMAELTTGPFYAVDASTDARLFPLSCMTVGGLLVDEATG
AVKGLSGGPVPGLYAAGRSAVGICSNLYVSGLSFADCIYSGRRAAKAIAAAGIYASGPHV
ASLS
>A0A2G9FZN4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Handroanthus impetiginosus|TrEMBL
MRILRWGEDRRFDEMRENLGKLAVFWIFQAVWVWTVSLPVTIVNASDRDPSIQAADIIGW
IMWSLGIFVEATSDQQKLMFKNSPQNRGKWCDVGLWKYSRHPNYFGEILLWWGIFVAATP
VLENAEWLVIFGPIFLTLLLLFVSGIPLLEESADKKYGNVSAYRHYKRTTSPLILLPPEL
YGKLPSWFKTTLLFEFPLYSRNLPQEN
>A0A375GGU8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cupriavidus oxalaticus|TrEMBL
MHPDSVTPVYAPLRLDDPDAHPWQAACDAVVVGFGAAGACAALEAARGRARVIVAERFEG
GGASAKSGGVVYAGGGTSYQAAAGYADTPQAMADYLRQETGGVVSEATLQSFCERSRDML
AWLEDVGVRFAATVPPRKTSYPAQPYYLYYSGNEAVPAYAQHAAPAPRGHRVKGPGMSGR
TLYGALRAAVEARAEITVMRQAAARRLIVGKDGAVIGIELWQVPPGRHQRRHARLARLAE
RLHNAMPGVADLLRQRLLQLELRHAQPVAVRTRAVVLATGGFIFNRTMVARHAGKYLQNW
RLGATGCDGSGIRLGESAGAATRHLERVSAWRFINPPFEWARGCVVDAQGTRIGNEETYG
ATLGHAICERHGGRAWLILNRALARAALRECLGGRLWAFQAVPAAMLLLAGARRASSIEA
LAGKLGMPPAALRATVDAYSAAARGEIPDPAGKSAPMCASLEAGPWLAIDISANSRVFPC
PAITLGGLSVEESSGRVLAVAGGAPISGLYAVGRTAVGIASNHYVSGLSLADCIWSGRNA
GRHLTQQPAGERQAHTNEEITHEPTY
>C9ZV08|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)|TrEMBL
MMTSQSHSPFTEASGFAAAVTLLFTAMGMVILSSHLMPLTGPRVLELSSKIHLTMAAGTF
LLLRFALIAPFGKHSGLSKVRIRVPALLSWSLQECPTLLSIIYYIVVEYPCCVHQCNPLQ
WLHMILDRPSMEVTTTVASAAPTLRLGLLFFAAHYFNHSVLYPLRVANHGTSVPLHITLS
AMLYCALNGRLQLLANIDSVDASQRLVVDSTWQTILTILGAVIFFAGMLVNVTSDCYLIR
LKKRPPLGAYKIPYGGLFVFVSCANFFGEIVEWFGYVAVVYGTNGTVAGLAALSFAAYVV
ANLLPRAYAHHQWYIQHFGAEYTALQRRAVIPFVY
>A0A5S9NG91|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycolicibacterium vanbaalenii|TrEMBL
MNSTGSDFDVVVVGFGAAGACAALAAAEAGARVLVVDRALGGGASALSGGIVYAGGGTPY
QQAAGVDDNPDNMFDYLRQEVQDAVDEETLRRFCNGSVEQLEWLESHGARFDSSLCGYKT
SYPTDEHYLYYSGNEKAYPFHLHSSPAPRGHRQVAKGMSSGRVLWEALRDSALRLGVTFW
PRTLVDELILEGGHVAGIRCRTMVDDGSRNSRRYQRAASAAAKLTNWTPPLGHLLNRRAE
RSWRRTARPRTVHAPTVVLAAGGFIFNRDMLRRHAPTHVLVSPLGTEGDDGSGIALGVSA
GGATAHLNQVTAWRFISPPSALVEGIAVGIDGTRIANEDLYGATHAEAMIRHYGGKGFLI
VDSRVWRRARSQLLSHTQLFQRATMAPVFAVAHRKADTLAGLADKLGVSGTGLTDSVTAY
NGAIADGRDDPMHKAAELCTPILQPPFYGVDISLKSSPADFVPGLTLGGLTVDTATGNVR
TAAGDRVEGLYAAGRTAVGICSKSYVSGLSLADCVFSGRRAGRHAARTSSTAAHATDLQA
RPVS
>A7AMG6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Babesia bovis|TrEMBL
MNILLKQSNGAFIERISIADDATVDDLRQLFYEKSDGVKLVENRLSDYGITDDTSLYFKD
LGVQISWRLVFFLEYLGPLLILPLLYHFPGIFYRTNDVPKNNVQVFTFVMLMFHFTKREL
ESLFVHRFSRSTMPIRNLFINCFHYWILCAVGIGYFVFHPRYTEIILLWRYEKIVLIILF
FYFQFMTLMTHLTLRNLRPKGTRVRGIPNNWGFQYVSCANYFWELMIWVVVALFTNTISS
YIFVFAVGAILSQWAMSKHRKYIKEFSHYDRRRRALIPFIY
>A0A086JPM2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii p89|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>G0QIR2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Ichthyophthirius multifiliis (strain G5)|TrEMBL
MQDLKQRNVLNQNNQQTTSSQQKNQLYSSTYPHDHPLAKFRQCVSTDFLGGPKIFQLNHI
INTFKGSTGIFLILLMCYYNNFSLSAYLIFILHGSYGFIWIAKDLLFPDKSWQVKQTIFS
SLVACAILLSYWSIGWFIISRRAITNPSLERIAVSCFCYIFGVTLMVVSDVQKFITLKYK
QGLITDGLFSRCRNPNYLGEIILYGGFAIVGGAWENYALLLFIWTTLFNLNIYLKELSFS
KKEGWEQYKNKSYLLLFKFFDEDIHNYLFYGGLAAFITINYSYGGLINVLKQQ
>A0A3Q8INK5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania donovani|TrEMBL
MKVIVASGPDGARKHEVELAASATLADLKKAYQPGVDVHRKSFKVPSTESPLPGADGGKL
RPNLITLSDKVPLSQQGVKDGSVIIYKDLGPQIGYRTVFYVEYAGPIAFMLMYAMRPSLI
YGSAPMPAYGYTQKLYIGLFLAHFFKRELESMFVHKFSHPTMPMRNIFKNCVYYWSFAAF
IGYVLCSPSFTPTSAAQSNFGAVFMTINELLNFAVHYQLSTMRKSDGDTTRNVPQGPLFA
FVSCPNYFFEIMSWVSFSIGTNMLSSWLFTLAGFVQMADWAKKKHRGYVKADPANKKKAA
ILPFIM
>A0A139KH05|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Bacteroides uniformis|TrEMBL
MNQETFQIFLWVMSAVALVVFIALYFVKAGYGMFRTASWGISINNKLAWVLMEAPVFIVM
FGLWGKSGAGFAVPVYFFFLLFQLHYLQRAFIFPFLLKGKSRMPVAIMAMGIVFNLLNGM
MQAGGLFYFAPEGLYADGWAYLLKPHALLGIILFFAGMFVNLHSDYVIRHLRRPGDTKHY
LPGKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWTFANLVPRADAIHRRYREEF
GDEAVGKRKRIIPFLY
>A0A5S9QPP7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|BD1-7 clade bacterium|TrEMBL
MLKSLIDKIRYREPYQEQHMVIDQPDKFRWDTVTDLAIAGFGGAGAACALEAESQGLRTM
VIDRFQGGGATTISGGIYYAGGGTRIQKEAGIEDSPENMFNYLKREVQGAVSDDTLKQFC
DQSVDNFDWMEANGVPFDASFCPFKTSYPPDHFFFYYSGNESFAPYNKDATPAARGHRGH
RKGISGAAIFEPLRDSVLKKDIDVRTQTKLVSLLTNTDGDVIGLKAIEVKDSFFGKITHR
VLNKLSTLLRYMALYWPPLFNLMGMLSEKVEMASGRSLYVRANKGVVLATGGFYSNQKMV
KEHAPNFVGGSPLGTLADDGSGIKMAIDLGAQSELMDSVSAWRFINPPTSFAKGILVGPS
GKRICNELLYGAQVGERMMRDHDGKAWVILDEATYKQARKDLTLKRALWFHVLLGGMYLW
CGSKKANSIRGLAVKLGVDPEAMADSVKAYNTVAQSDDVDPMGKPKDFMTAIENGPFYAI
DASYDYFYVPCPSLTLGGLKVNEASGAVVTENGDDIKGLYAIGRTAVGIPSRGYVSGLSI
ADCVFSGRRAARHAAENSNTVVDFQQATGT
>A0A3S7WUK3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania donovani|TrEMBL
MSADARIAIIAVVHLALTWVLLRYIADSAMPFYVHREGSSPAGAANGASVRRAVAHEWDQ
WSPFLVPSQEAYAAQLGRQQRATSAADAVALNSRVVWRSSAFHLTLAIFTYALLRFGVTA
PYGRHSWALGFQLTLPSRVSWMLQESQTIFQVIYHVFLEYPRLMGHSPSWPSLWPSSSSA
SGPTAAGMPSSHSSADTCHSYWGCVRAACTQQHLGLLLFVIHYVHRSWLYPLSIPATAHD
VPLVVTWMATMYCLFNGRLQVLASAGAAATACATDTAAPSLACTPAYTASMGFVRCWRER
HELQSLHSSSASVGAVAVRVGWRLLLGLYAIGVLGGSALFFLGQRINMQADYYLVRLRRG
DKGSISHGGSKPVGRRAANLHGDALATSSSLEASRDAQHRSSIDGYRIPVGGWFDSVSCA
NFFGELVEWTGYVIVVAATSATSNGNCLSVTTALEEELLQPLSSSSWWSLMNPIMWLRLV
ARVFFGGSESRPAALAAFSFLVYVFSNLAPRAVAHHAWYAKTFGDPYTRLGRQALIPGVY
>A0A498P8Y3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium persicum|TrEMBL
MAGDKSARICESADVVVIGFGAAGECAAIAARERGADVIALDRANGGGATAISGGIIYAG
GGTTVQRQAGVNDTPEQMLAYLRVEVGDAVSPETLESFVRSSPDMIDWLSSYGVPFSPAL
CPYKTSFPNNRYYLYHSGSENAGAFRSHTPPVQRGHRVKGSGTSGRKLYAPLAKAAVALG
VRFWPHTTVTNLIQDSSGRVTGVEALTMHNAPPRIRRLYAAMAELSAKPGIYYPPLRRLL
EGRLRRLERRYAQPLRIDAGRAVIICAGGFIANTDWVRRFAPQYLGGLQLGTSGDDGSGI
ALAQRAGAVTDRMDNVSAWRFITPPSAFIGAIIVDKRGDRFIDESRYGAAVGQAMIRQHQ
GAGWLLADAALMREARRQMIKQPLWFQRAQVAALMLADAATAPSLREVAKAAGVDPDGLV
ATVEAHNNAIDTGAADPVGKPAEFVRRISQPPFTLLNISVRPSLLNPTPMLTLGGIRIDE
RSGAVVDQSGKPIPGLFSAGRTAAGICSNSYVSGLSLADCIFSGRRAGTHAVMASAEEIP
H
>A0A7W7D1R0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphaerisporangium siamense|TrEMBL
MSTASTAPVPVSRVHHWAAEADVLVAGNGCAGASASIEAVAAGAEVLVVDAAGGWGGATA
MSGGEIYLGGGTSVQKACGFEDSVDAMYAFLKLATGPDPAEDKLAVYCEGSLEHFDWLVR
CGVTFVPKLWTNPSWEAPTGYGLMYTGGENAYPFADLVPPAPRGHIVDMEGKQPGERSAG
WMLMKHLAATQERAGVEVRYNTRTERLVVDGERVVGAEVVSFGERYFVRAWRGVVLAAGG
FAANPAMLAQHAPKLAAPGNFLVGTDNDDGRGIRMGQAVGAAVRHMEAGQSAFPADPALL
FRSLLLNGRGHRFINEDTYPGRVGQTTLFQQDRKAFLLYDEATNEEASRQAEHVVQPTWV
SDDLGELAKEMGIAPEVLAATVATYNAGAARGEDPECHKAARWLRPLVPPYGVLDLRDGP
YGVFTIGGLHTSTRGEVLGLEGDPLPGLFAAGRTTSGIPSWGYCSGTSLGDSTFFGRRAG
RAVATA
>A0A829MAZ1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacteroides abscessus MAB_091912_2446|TrEMBL
MLTELYHTAIVFLVVLAVVTFVSGFWFTNPYGRFAKPDETFTAPAKLGWLIFECPQWWAF
TVTFWTVAHHHGAPALMLYGLWQCHYLYRGLLYPLWRKDSGKRFPYSGIAFGFLFNAING
FANGYAVACAAHLQSGAWFTDPRFVFGVLIAVVGWIVNFQADRILINLRSDGFGGYRIPY
GGAFRWVSAANYLGEIILWAGWALMSWTLPGLIFVVFSIANLLPRALSIHRWYRQTFPTE
YPRERKAIVPGLL
>A0A1K0IB27|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cupriavidus necator|TrEMBL
MCPPPDSATPVHAPLRLDDPDAHPWQAACDAVVVGFGAAGACAALEAAHGGARVIVAERF
EGGGASARSGGVVYAGGGTPYQSAAGYADTPQAMADYLRQETGGVVSDATLQAFCQRSRE
MIGWLEGLGVHFAATVPPRKTSYPAQPYYLYYSGNEAVAAYAQHAAPAPRGHRVKGPGMS
GRTLYGVLRAAVQARPEVTVMRQTAARRLILDQDGAVVGIELWQLPPGRQQKRHARLARL
AERLHNAAPALADLLRERVLQLELRHARPVAVRTGAVVLATGGFIFNRAMVARHAGKYLQ
TWRLGATGCDGSGIRLGESAGAATRHLERVSAWRFINPPFDWARGCVVDAQGARIGNEET
YGATLGHAICERHGGRAWLVLNRELARAALRECLGGRLWAFQALPAALLMLAGARRASSL
EALASKLGMPGAALRATVDAYNAAARGEIPDPAGKSAPMCASLETGPWLAIDISANSRVF
PCPAITLGGLSVEESSGRVLAAAGGAPIPGLYAVGRTAVGIASNHYVSGLSLADCIWSGR
NAGRHLTRQPAGDRQAHTNEETTHEPTY
>A4I1M5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania infantum|TrEMBL
MKVIVASGPDGARKHEVELAASATLADLKKAYQPGVDVHRKSFKVPSTESPLPGADGGKL
RPNLITLSDKVPLSQQGVKDGSVIIYKDLGPQIGYRTVFYVEYAGPIAFMLMYAMRPSLI
YGSAPMPAYGYTQKLYIGLFLAHFFKRELESMFVHKFSHPTMPMRNIFKNCVYYWSFAAF
IGYVLCSPSFTPTSAAQSNFGAVFMTINELLNFAVHYQLSTMRKSDGDTTRNVPQGPLFA
FVSCPNYFFEIMSWVSFSIGTNMLSSWLFTLAGFVQMADWAKKKHRGYVKADPANKKKAA
ILPFIM
>A0A840NJJ6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Saccharopolyspora gloriosae|TrEMBL
MENRFQSEDVVTEELWADVVVVGFGVAGACAAIEAARGGAEVVLLDRFSGGGASRLSGGV
VYAGGGTRLQREAGVADTVEDMYEYLRLETGDAVSEGTLRRFCEQSPEMITWLEECGVPF
GSGLAPYKTSYPSNRHYLYYSGSEASGGFRDVARPAPRGHRAYGRGTSGKVLFAALAAAV
RAAGVRIVDQTRCTDLITDPTGRVRGVQCESLTTASRRARRTHRAAAKFAAKPGLYVPAL
GKRLHAVAERVERRHARPLRVRARRGVVLAAGGFVANREMLRRHAPLYRGGLPLGTRGDD
GSGIRLGTAAGGATDKMEKVSAWRFITPPSPFLGAVLVDEHGDRVCDESRYGAALGDALI
NHHGGRGWLLIDAELRREALRRLREQTVWFQLMQALHLLGGRSVSAPTLAEVAVRAGIDP
VRLRKTAEAHDGAADGEDPAGKPAEFVRRLRTPPFTLLDISIRPSVAYPCPMLTLGGLVT
DETTGAVLDDDRAPIPGLYAAGRTAAGLCSNSYVSGLSLADCVFSGRRAGRHLAGTDADG
>M2XFK3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Galdieria sulphuraria|TrEMBL
MWNIDLLAHITLFEEEIYDYLFLFFLFLGAITFPLLLVVDAPYGKLFSSSWGPTVRTDVG
WIIQEAPAFFLFLLFALKSYSRLQEPAYMLLSLMFLGHYLQRAFIFPLLMKTPGKPTSLI
VVLSALGWNVINGYLVGRGLFHFEAKLSRDWYRNPIFIVGALCWLCGFIINLHSDHILRN
LRKPGEKGYKIPHGGLFRWVSCANYFGEMVEWSGWALASQSLAGALFVFWTVANLLPRAI
RYHQWYIQKFSSYVTFNRKACIPFLI
>A0A5E7HCD6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATFDDSFYTPIQTPLQVADSSALLWDEHCDVLVIGWGAAGACSALEARALGANVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVISDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPEHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKDACLRAGARPLLQASAKRLVVDAQGRVVGAEMWCITPGTPQAELHARLA
ARAERLQNFAAGYCNKLRQRIGQLERDFARPRLVHARNGVILSTGGFIFNRELIKRHAPK
FLRNFKVGATGCDGSGLRLGTSVGGQGAGLERVSAWRFLNPPYSWHKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSLPALVLMLFKVRKG
KSLSELANATAMDPAVLRASVLAANAAARGEAPEPFGKSPGGRQVLDQGPFYACDISVTN
PVFPLGALTLGGLRVDERTGAVLDQQGQAIAGLYAAGRSALGIPSHLYISGLSLADCVFS
GRRAGAAVARPQGEQFQTTHAHEMT
>A0A5E6RHX2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MSMFDNLPSTDVLPPLQVADGESVHWDDRCDVLVVGWGAAGACAALEARAQGADVLIADR
FTGGGASVKSGGVVYAGGGTRHQQAAGFNDSPEAMFDYLRHETQNVISDDTLRRFCTDSV
SNLEWLESHGAPYAHQMPPGGKTSYPQDGYFLYYSGNELVPAHGGPSPPAPRGHRTVGKG
QGGAVLYSHLKVACLKAGARPLLQAAARRLVTGAQGRVLGVEFWCLPEGSKEAQLHARLA
ARAERLQNFAPGYCNKLRVKVCQLERDFARPRRVQARNAVILSTGGFIFNRQLLEQHAPK
FRRNFKVGATGCDGSGLRLGTSVGGQGHGLERVSAWRFLNPPYSWQKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSFPALALMLFKVRKG
KSLSELASATSMDAAVLRESVLAANAAARGEAPEPFGKSEGGRQVLNQGPFYACDISVTN
PVFPLGALTLGGLRVDERSGAVLDEQGQAIAGLYAAGRAALGIPSHLYISGLSLADCVFS
GRRAGRASALRQSGDD
>A0A7X5UVE5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Saccharomonospora amisosensis|TrEMBL
MVEQWDAEADIVIVGFGGAGACAAIEATDRGAEVLVVDRFRGGGATEISGGIVYAGGGTE
HQVRAGYSDTTQAMLDYLRLEVEDVVSEETLARFCEQSVENLRWLESNGVPFEGSMSPRK
TSYPTNDYYLYYSGNELAPPFRDKATPAPRGHRTKGRGTSGKVLFKALRSAVAKRDIAVR
FQTRVTELVTDESGHVVGIECRELANGLPRLFHRLLSQSNRKLNIYYRPLGKLLDKPIRR
IERRHGKVRRFRARRGVVLAAGGFVFNRKLVSEHAPAYRGGSSLGTIGDDGSGIELGRSV
GGRTDCMNRVSAWRFYNPPLALVEGVLVNTAGERICNELYYGARIGDHIARQEGAKAYLV
VDSRVLEEAKRQLPSQTLWFQRLQATYLFTIGHHKGGQLEEAARRAGIDPEGLRRTIEDY
NADACAGAPDRMGKDGDHVRPLERGPYYVFDCSLRAQRGYPCPMITLGGLAVDERTGAVL
ATDGSTVPGLYAAGRNAVGVCSHSYVSGLSIADCVFSGRRVGAALAGAD
>A0A846MCD0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphingobium vermicomposti|TrEMBL
MKVADMNSLGGEPVISIDSADTFQWDDEADVVVVGYGGAGICAALELVENGASVIAIDRF
NGGGATAFSGGVVYAAGTDIQRQNGVEDDPDNMLKYLRLEVGDIVKPETLKRFCDDSAAN
LQWLQAHGVVFGTKLYTGKTTYPPEGYFLQYSGNEKVEAYCREAKPAPRGHRTLGRGFTG
NKLYHALRQTADQSAIRPMLHTIVQSLVVDRSGRVVGVAALQLSRDKQAEHQKYYDKFPP
TAPFKEAKAEAAGRAARAMETEHGQLRYVRAKAGVILSTGGFAFNLDMLSQHAPVLTQHY
KTMMRLGTLGDDGTAVRLGTALGADTAGMDAMFVGRVQSPPAALLDGILVNQAGDRFANE
AVYVGTLGRAIADQPEGKAWLIMSAKDVRKAMRQVVTGGFDAFMRFGAPAMLNLLLGGTK
RARDLDVLASKCGLNPARLRQTIRRYEDMVRDRHDDDFSKLKDHLKSLGSGPYVAMNVSL
ANRFSFITFHTLGGLALEETTGAVRRADGSSIPGLYAAGRATGSIPSRTYISGLSLADCV
FTGRRAAQSCLGVIAAENRPSLSLSD
>A0A839QAR0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycolicibacterium iranicum|TrEMBL
MTRQRTSADVVVVGYGAAGVCAALESRARGADVLAVDRFDGGGTTQVSGGIIYAGGGTWV
QRAAGIEDSNDAMYAYLQAEIGDAVRPETLRRFVDSSPGMIDWLTGHGVPFEASVCPYKT
SFPNNNYYLYFSGSENSGRFRAVTPPTQRGHRAKGPGASGKKIYEPLARSAARLGVRTQF
HTRAEKLLVDERGRVTGVRVSTLADAPSHVRSRYRRCAALAIKPGIYYPPLRAAMESLMA
RIEQRHARTVDIRARKGVILSAGGYIANRQLIGEHAPAYLDGLQLGTSGDDGAGMQLAAE
LGAATARLDNVSAWRFITPPSAFLSALIVDSAGHRFIDETRYGAAVGHAMVQEHEGRAWI
LADDELLRTARKDLPRQAIWFQRLQMEAMLRFDRVVADTVELVATKAGIDPGGLRGTIAA
HNAAAAGGQPDPMGKPAEFVRPVGAGPFSLISIAVKPSLINPCPMFTLGGLVVDETSGAV
LTADRQPIEGLYAAGRTAIGICANSYVSGLSLADCVFSGRRAAEHVVEQSSTHHTDP
>A0A0B2S5G4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Glycine soja|TrEMBL
MKVTVVSRSGREVVKGGIELSDSATIADLQEAIHKRTKKYPSRQRLTLPVQPGSKERPVV
LNYKKSLKDYTSGNSETLTVVFKDLGPQVSYRTLFFCEYLGPLLLYPVFYYLPVYQYFGY
KGERVIHPVQTYALYYWCFHYAKRILETFFVHCFSHATSPLSNVFRNCAYYWTFGSYIAY
YVNHPLYTPVNDLQMKIGFAIGILCQISNFYCHIILKNLRSPGGEGGYQIPRGFLFNIVT
CANYTTEIYQWLGFNIATQTVAGYIFLVVATFIMTNWALAKHRRLKKLFDGKEGRPRYPR
RWVTLPPFL
>A0A3E2MNS0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium marinum|TrEMBL
MADDTPEHIVESTDVVVIGFGAAGVSAAITAREQGVQVVALDRANGGGATAISGGIIYAG
GGTAVQQQAGVRDSLEQMLTYLRLEVADAVSESTLESFVRGSPEMIDWLSHYGVPFDSTV
CPYKTSFPNNHYYLYHSGSENSGAFRSHTPPVHRGHRVKGKGTSGKQLYAPLAKAALSLG
VQFYPHTKVTKLLQDSTGRVTGVEAMTMHDAPPRIRRTYAALAAVSTKPGIYYPPLRNLM
ERRLRALERRYARAVQIRARRGVILCAGGFIANSEWIKRYAPRYATGLQLGTSGDDGSGI
ALAQSVGAVTERMDNVSAWRFITPPSAFISTVMVDQQGQRVIDESRYGAAVGKALVQDHN
ARAWLVADADLMNEARRQMLKQPLWFQRAQAAALMVADSVRAETLARVARKAGVDPDGLQ
ATVDAHNSAIDAAATDPAGKPAEFVRRVARAPFTLLNISVRPSLLNPTPMLTLGGIKVDE
QTGAVLDASGAAIPGLFGAGRTATGICSNSYVSGLSIADCVFSGRRAGNHAAIE
>A0A086KFX4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii GAB2-2007-GAL-DOM2|TrEMBL
IACLSFVVATMTVNASKTHTWYRRTFGDAYPQNRRALLPLVY
>A0A3R7RLV9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma conorhini|TrEMBL
MPERPRGSSASTWRALLAAAVCFLAAAPCMVLLQQYLLPLGDARAVASASRFQLAMAVVT
YLTLRLVRVAPYGRHAEGTFLGPTVPAPLSWALQECPTLLSVTYYLFVEYPCHSLGCSGG
QWTRIALEDTWGQAARAVADGLASLHLGLLLFVIHYVHRSLLYPLLLRSGTPVPIEITLA
ATLYCLLNGRLQLLANIRDSPAVPRLPLDSMSHMMLFFVGSVVFFAGMWVNLFSDYHLLR
LKEQPPKRTRKIPHGGLFEYVSCANFLGEIVEWGGYTLVVWSTTAASKPEAGLAACSFFL
YVMANLLPRGQAHHAWYIKHFGDAYKALRRRAVVPYVY
>A0A7W7VBF5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinophytocola algeriensis|TrEMBL
MPLEWDEHADVVVVGFGGAGACAALEAARAGASVLAIDRFTGGGATAVSGGIVYAGGGTS
VQKAAGVVDTVDDMAVYLRQEVGDVVSDATLREFCASSADMVDWLTEAGVPFDSTVCPYK
TSYPTNDYYLYYSGSENAWPYRSSAAPAPRGHRTHGRGTSGRVFFAALASAARAAGVRVL
PQTTATSLVVEDGRVVGVECRTLRSRWHAVLHRYATKPGLYIPGFARKLHRRISALEDRR
GRVVRIRARRGVVLSAGGFVNNRAMVRAHAPEFRGGLPLGTQGDDGSGIRLGESVGGVTD
RMSTVSAWRFLTPPSALLRGALVDASGSRFVDESSYGAAIGSRLVRERGGKAWLLVDETI
LRDARRQIRRETLWFQRLSAHYLLRVALVRGPSVEEVARRSGVDPAGLAATVAAYGRGED
AFGKLPELVAPLAAPYALIDCSYGPRLGYPCPMLTLGGLVVDEKTGQVLDVPGLYAAGRT
AVGICSNSYVSGLSLADCVFSGRRAGRHAAKIV
>A0A4R8SRL1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacteroides salmoniphilum|TrEMBL
MPGDVEVPAVPSPDVVIVGYGVAGASAALAALERGASVTILERFDGGGASAISGGIYYAG
GGTNIQRDAGVEDTAELMLEYLQLEVGDAVKPETLQKFVDGSVDTLDWLQGYGVPFEGSL
APFKTSYPTNDYYLYFSGSESSGMARAVTTPRQRGHRAFGRGVSGKALFAPLAASAERLG
ADVWRQTRVTGLIVEDGRVVGVRGVTLKDAPTWVQRAYSRLTRYATKPGIYYPPMRKVLE
GPAYALERRFATPFEIRANDGVILSSGGFIANRELVERYAPAYRDGLQLGTAGDDGTALT
LAEPLNAATGHLDEISAWRFIVPPAAFLGSLLVDAKGQRMVDESRYGAALGKAIVQKAGG
VGYLVADRALVKRARQQLGSQTLWFQRIQAEAFLNVGRKRAGSIAALAAKAGIDPELLAR
TVSEHNRAIADGAPDPLGKPDDIRVPIEQGPFFLFNVSIKTNMLNPCPMLTLGGLVVDEE
TGAVQTTSGAAIPGLYAAGRAAVGICSNSYVSGLSLADCVFSGRRAGTETGRHIDA
>A0A1C6YEZ6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium berghei|TrEMBL
MKVILRKRNGKFIDYFDISPSTTVDQFKELFYKKYHYYPERQKWNLDNATGKTLISGTLS
EVGIKDGDILIFKDLGVQISWRLVYVIEYLGPILIFPFFYFCDKYIYSHNAKNKHIIQIL
SLWFLLFHFLKREFESLFVHRFSNATMPIVRVPINCGHYWILCGVNIGYYLFHPKYKPHN
LCSKPHIVYSIFFVLLVLEFLNLKCHLILKNLRPRGTKTRGIPYGYGFNYISCANYFYES
LIWIIFSLITNTLTGYIFCCVAIAQMAIWALKKHNSYKKEFPNYPKNRKAIFPFVL
>A0A078K7D1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium yoelii|TrEMBL
MKVILRKRNGKFIDYFDISPSTTVDQFKELFYKKYHYYPERQKWNLDNATGKTLVSGTLS
EIGIKDGDILIFKDLGVQISWRLVYVIEYLGPILIFPFFYFCDKYIYSQNAKNKHIIQIL
SLWFLLFHFLKREFESLFVHRFSNATMPIVRVPINCGHYWILCGVNIGYYLFHPKYKPYN
LGSKPHIVYSIFFVLLVLEFLNLKCHLILKNLRPRGTKTRGIPYGYGFNYISCANYFYES
LIWIIFSLITNTLTGYIFCCVAIIQMAIWALKKHNSYKKEFPNYPKNRKAIFPFVL
>A0A498QJK8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium innocens|TrEMBL
MAGDKSARIYESADVVVIGFGAAGECAAIAARERGADVIALDRANGGGATAISGGIIYAG
GGTTVQRQAGVNDTPEQMLAYLRLEVGDAVSPETLESFVRSSPGMIDWLSSYGVPFSPAL
CPYKTSFPNNRYYLYHSGSENAGAFRCHTPPVQRGHRVKGSGTSGRKLYAPLAKAALALG
VRFWPHTTVTNLIQDSSGRVTGVEALTMHNAPPRIRRLYAAMAELSAKPGIYYPPLRRRL
EGRLRRLERRYAEPVRIDARRAVIICAGGFIANTDWVRRFAPQYLGGLQLGTSGDDGSGI
ALAQRAGAVTDRMDNVSAWRFITPPSAFIGAIIVDRRGDRVIDESRYGAAVGQAMIRQHQ
GAGWLLADAALMREARRQMIKQPLWFQRAQVAALMLADAVTAPSLREVAKAAGIDPDGLV
ATVAAHNTAIDTGAPDPAGKPAEFVRRISQPPFTLLNISVRPSLLNPTPMLTLGGIRVDE
RSGAVVTESGEPIAGLFSAGRTAAGICSNSYISGLSLADCVFSGRRAGTHAATTSAAQSP
R
>A0A4R8RAC5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacteroides franklinii|TrEMBL
MPGRSDMPSADVVIVGYGVAGASAALAALERGASVAVLERFGGGGASAISGGIYYAGGGT
NIQRDAGVEDTPELMLEYLQLEVGDAVKPETLQKFVDGSVGTLDWLQGYGVPFEGSLAPF
KTSYPTNDYYLYFSGSESSGMARAATPPRQRGHRAFGRGVSGKALFAPLAASAERLGADV
WRQTRVADLIVENGRVVGVRGMTLRDAPGWVRRLYSRLTDYATKPGIYYPPMRKALEGPA
YALERRFARPFEIRANDGVILSSGGFIANRELVRRYAPAYLDGLELGTAGDDGTALKLAE
PLNAATGHLDEISAWRFIVPPAAFLGSLLVDAKGQRMVDESRYGAALGKAIVQKAGGVGY
LVADKALVKRARQQLGSQTLWFQRIQAEAFLNVGRKKARSIEELAAKAGIDPDALARTVS
EHNQAIADGTPDPLGKPDDIRVPIGQGPFYLFNVSIKTNMLNPCPMLTLGGLVVDEETGA
VQTTSGTAIPGLYAAGRAAVGICSNSYVSGLSLADCVFSGRRAGTESRLDTVRRS
>A0A7Z0AW02|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas moraviensis|TrEMBL
MDAQQQLSALRVNSADQLDWDDRCDLLVVGFGGAGACAAIEAATRGLSVLALDRFAGGGA
TAISGGVVYAGGGTPYQRQAGYEDSRDAMFNYLRQEVGEAVSPQTLREFCEGSCEQLTWL
ERQGVAFESSVPPHKTSYPSDRFYLYYSGNEAVPAYAAIAKPAPRGHRTKGPGMSGASLF
APLKTSALRLGARLRSQCEVRRLVIDANDRVVGVEAWKLPTGSRAARQHARLSHWATAIH
MYAPAVADRLRARLRRIELASAERQLIRAEQAVLLSSGGFIFNREWVGQHAPRYLPGLPL
GTTGCNGSGIALGQSAGGRVARMDKVSAWRFINPPLAWARGLIVNARGERYANEEIYGAT
LGHAMVEEQDGRAILILDRALVREALRQVGPGKVWAFQRLPVLLNLLFNARRSRSLVELA
KRCGLPPDNLQRTVNTYSRAARADIVDPFGKSPAMLADMDQGPWYALDLTFASRLFPCPV
ITLGGLKVCETSGQVLNHADQPIAGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAAY
VAEQLAAQTTRSGEQQCNV
>A0A1S7UKI4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Rosellinia necatrix|TrEMBL
MAIVEGWLPASRENWETLMWWWQFYPLLGSLQWFSSWYGMGKTSVDSRLNMPGRVAWFTM
EVPGFITLLYTMSTLPTQHGITDLPWQNKVLASLFVMHYIYRAVFFPFLQPSMSPIHVQI
WVMAVIFQVCNGTAIGCWLAAYGPTTQAQWEAQGFSVIQFGIGLAVFYVGLAGNYFSDEE
LREIRRSEMKRQERLKQQGKTIDKHYEVPQNGLFKYMLFPHYFMEWVEWTGYCIAGGLAF
TPARCFLMNEFFAMLPRAVAGGKWYRERFGADKIKGKYVVIPGIY
>A0A6G8NPG4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Caballeronia sp. SBC1|TrEMBL
MSTPSGRVKGAATPVEAPLVVTDPACMRWDDVCDVLVVGYGAAGACAALEAAEARSVVRI
VERFEGGGASAKSGGVVYAGGGTRYQTEAGYADTPEAMFAYLQQEVGDAVSAATLKRFCA
GSVDMLRWLERIGVRFASSVPPRKTSYPQDRYYLYYSGNEAVGDMPRESPAAPRGHRVVG
RGMSGRVLFDTLRHAVESQPLIDTMCHAAVRGLITDTKGRVIGAQIWQVAPGRAQRWHRR
FARWAERVHNGLPGLADRLRAALHRIELRDGRLLTIKANAVVLTTGGFIFNRAMVAQHAP
HYLQNWRLGTTGCDGAGIRLGVSAGGLTKRLGRLSAWRFINPPYAWAQGCVVDRHGERFC
NEEVYGAALGHAMCETREGRAWLILDARLVGLALHECLRGKLWAFQSVPAALLMLLGCKR
ARSLAGLAKRIDIDPAVLQYTIDTYNTTALDGRDSAFGKSAAMLQPLMRSPYYAIDISSD
SRVFPCPSITLGGLHVDETSNAVLSATGAPVEGLFAAGRAACGLASNHYVSGLSLADCIW
SGRQAGRAAAGAVLANCAHSLTETD
>A0A7W4W5B2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Litorivivens lipolytica|TrEMBL
MTTHLSRRSLVAGLAAAPLAASALPSSTVKSWFASVDVIVVGSGVAGTSAAIEAASAGSK
VLVLEMLPKLGGSSAMSGGVVYCGGGTALQKACGVEDTVEAMRDYILTASGLYAQTDKVE
LYCEQSVAHFDWLVAQGVHYQPSYTPAKGLPGTSDSLYYSGSEQVSEFADKIPAAPRGHV
PGHSGWTGGRSLMEALIPAARRAGVQYLTGVTCQRLIVESDGRIGGIQVEMDGATRQLRA
KRGVVLAAGGFIHNREMLQVYAPELAQCSVPWGNMGDQGLGIQMGVSAGGATAQMHHGFA
IMPLYLPDHVLKGIVVNDKGQRFITEDHYHAFLGHDIAFHQRGKAWLITDKTSQYGYDDY
RVTEVVRAATVSELAEKLPMPKDALLETLGYYNRHARAQQDPLFGKSREYLSPIGEAPFV
AYDLSVDKAFFPAHTFGGLRTNLNAQVLNGFGEAIPGLYAAGRTSAGLPVAPYIASGISL
GDGSFFGRRAGRHAAESRV
>A0A5E6YJ07|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MSRAQHTSSNSKILAPLQAERLSAGDWHDTCDVLVIGWGAAGACAALEASSNGARVIVAD
RFTGGGASAKSGGVVYAGGGTRHQQAAGFTDSTQAMFDYLKHETQGVVSDATLQKFCDDS
VSNLDWLESHGARYAHSVPPGGKTSYPSDGHFLYYSGNELVPSHAGTRPPAPRGHRTVGK
GQCGAVLYGHLKAACLRAGVQPLLQSAARRLVVDASGRVVGAEFWRLPQGSREARLHARL
AARAERLQNFAPGYCDRLRLKVSQLERDHGQPLLIRARRAVILSTGGFIFNRGLIRDHAP
NFRRNFKVGATGCDGSGLLLGQSVGARSERLSRVSAWRFINPPHCWPKGIVVNSNGQRFC
NEEVYGATLGQPLCDEQGGQAWLVLDARLRKQAIRQALFGGYWWFQSLPALALMLLKVRK
GDNPDRLASVCGMQAGELSGALRAYNAGARGDGPDAFGKSEGSRQVLDKGPFYACDISVG
NPIFPLGALTLGGLKVDESNGAVLDTDGQPIAGLFSAGRTAIGVASHLYISGLSLADCVF
SGRRAGLAASGRNVPGTTIASRLAPTDSARVTL
>A0A8J0PJ13|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Xenopus tropicalis|TrEMBL
MQCNQDMDYYMSLCLAIISVLFLIRQFTYPAAYGKHVATGKKQNGFMVPAKYGWFIQELP
SFLVPVVVILYRQQCNSLGCKMLSFMFCGHYFQRTFIYSAFTRGRPSPLRIVLMAVVFCT
YNGFLQGHCLVYVAEYPKDWCMDLRFISGVLIFCLGMGINIHSDHILRRLRKPSEVAYKI
PQGGMFNYVSGANFLGEIVEWFGYAIATWSLPGFAFAFFYSVLHWPEGLSSSQILPPKF
>F2ICP3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Fluviicola taffensis (strain DSM 16823 / NCIMB 13979 / RW262)|TrEMBL
MTQEQFYYFCYVWIGVGVIAFLGLQFKDAPYGKFTTSKWGPTMSNRWGWVIMEAFVLVVL
YYFILTSSKKLSAVDWTIVSLFTAHYINRSFIYPFRTRTKGKQIPVSIVGMALFHNLANG
FLIGYYLSHFSSYTNDWFTSWQFIVGITLFVIGMFTNIYSDTVLIRLRKNPTDGYKIPFG
RPFNLISAPNLGGELLEWIGFAILCWNLPAFCFAFFTFCNLFPRALANHKWYKQTFADYP
KERKAVIPFIC
>A0A3R7NDE6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Trypanosoma rangeli|TrEMBL
MTERSCGSSATTWKVLLVGALSVLATTVCIALLQQYVMPLGSAAVVVSASHLHLALAATT
YLVLRFVTVAPYGRYAESSQVHVAVPAPLSWALQECPTLLNVIYYLLVEYPCHSLGGGCG
QWMRLAFDDPLGEAAHVVADGLASLHVGLLLFVIHYVYRSLLYPLLIREGTPVPIEVMLC
ATLYCLFNGRLQLLANIRDGPAVSRFPLDSKIHMTLLFVGSVVFFAGMWVNVCSDYGLLR
LKAKPPKGTRKIPHGGLFKYVSCANFFGEIVEWCGYTLVVWSTTAASKAEAGLAACSFFL
YVMANLLPRGRSHHAWYEKHFGSAYKALRRRVVIPYLY
>A0A8H8XQD2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas sp. OF001|TrEMBL
MKHDAISTCTDIQLPLQVADASSLQWDDQCDVLVIGWGAAGACAALEARARGADVLVADR
FTGGGASAKSGGVVYAGGGTRQQRDAGYADSPEAMFDYLRHETQGVIGDATLRRFCESSA
ANLAWLEGHGARYAHSMPPGGGKTSYPPDGYFLYYSGNEMVPSHRGQHPPAPRGHRTVGK
GQCGAVLYGHLQRACLKAGVRPQTQSAARRLVLDARGRVIGAELWCLPAGSAAAREHARL
AARAERLQNFAPSYCDGLRRKLARIEQQHAKPRLVQARRGVILSTGGFIFNRAMIGEHAP
KYRRNFKVGATGCDGSGLRLGLSAGAASDRLQQVSPWRFINPPLCWPKGIVVNTAGQRFV
NEEVYGGTLGYPLCEEQGGKAWLVLDARLRRQAIKQALFGGYWWFQSVPALALMLLKVRK
GRTARELAGVTGMQPALLEESLRAYNAAARGTAPDPVGKSESSRQVLDQGPFYACDISVG
NPIFPLGALTLGGLKVDEDNGAVLDGQGQAIPGLYAAGRTAIGIPSHLYISGLSLADCVF
SGRRAGEAAAQANHTTTTRAAPAGAPA
>A0A1C6XKD8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium chabaudi adami|TrEMBL
MKVILRKRNGKFIDCFDISPSTTVDKFKELFYIKYHYYPERQKWNLDNATGKTLVSGTLS
EIGIKDGDILIFKDLGVQISWRLVYVIEYLGPILIFPFFYFCDKYIYSHSAKNKHIIQIL
SLWFLLFHFLKREFESLFVHRFSNATMPIMRVPINCGHYWILCGVNIGYYLFHPKYKPYN
LGSKPHLVYYIFFVLLVLEFLNLKCHLILKNLRPRGTKTRGIPYGYGFNYISCANYFYES
LIWIIFSLITNTLTGYIFCCVAITQMAIWALKKHNSYKKEFPHYPKNRKAIFPFVL
>A0A5E7ND10|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATFDDSFYTPIQTPLQVADSSALLWDEHCDVLVIGWGAAGACSALEARALGANVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVISDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPQHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKDACLRAGARPLLQAAAKRLVVDAQGRVVGAEMWCMTPGTPQAELHARLA
ARAERLQNFAAGYCNKLRQRIGQLERDFARPRLVHARNGVILSTGGFIFNRELIKRHAPK
FLRNFKVGATGCDGSGLRLGTSVGGQGAGLERVSAWRFLNPPYSWHKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSLPALVLMLFKVRKG
KSLSELANATAMDPAVLRASVLAANAAARGEAPEPFGKSPGGRQVLDQGPFYACDISVTN
PVFPLGALTLGGLRVDEGNGAVLDGQGQAIPGLYAAGRTALGIPSHLYISGLSLADCVFS
GRRAGAAAARFMDQQLQPTLAQETT
>A0A653VR77|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas sp. 8AS|TrEMBL
MTAMQLDPLAPIRVADGECLRWDDEADLLVVGFGGAGACAALEARGHGLDVLALDRFAGG
GATARSGGVVYAGGGTAQQQAAGYQDTPEAMFDYLRHEVGDAVSESTLRDFCQRSAEQIQ
WLEHQGARYEGSVPPVKTSYPSDQYYLYYSGNEAVAAYAGAAPPAPRGHRTVSSGQSGRV
LFAALRASALRQGVRLHTQCEVRRLVQDACGRVLGVEAWRLPEGSREARRHARLARWADD
LQPYLPALANALRRRLRELELNHGERRLIRARHGVQLSTGGFVFNRAMLAEHAPHYLAGM
PLGTGGCDGSGIRLGCSVGAVPARMDKVSAWRFINPPLAWARGVVVNAAGRRYCNEEVYG
ATLGHAMVEENGGRAILILNRQLMRQAFAQIGPGKVWNFQRLPALLSMLFNCKRGKTPAE
LAERCGLPAAALEQTLAQYSAAARGECADALGKSPAFLASLEQGPWYAMDLSFDSPLFPC
ATITLGGLRLDEASGRVLDSAGRPIAGLYSAGRNAVGVASNLYVSGLSIADCVYSGRRVG
AHVAGLVNAVQATRGEA
>A0A088RMW9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania panamensis|TrEMBL
MPTAMRTAIIAVVHLALTWVLLGYIADSAMPFYVYCAGGNGTAAAVSGTCVFAAATHDWG
QWPLFLRPSQEAYMAQLAQHQCAMSASDAATLNSRVMRRSSVFHLTLAIITYVLLRFVVT
APYGRHAEGLGLRLTLPSRLSWMLQESPAILQVLYHVLLEYPRVMGHGFSLSSKWSLSSS
TPGWIVAGVAGRDSSVDTCQSYWGCVWTAFTQQHLGLLLFSIHYVHRSWCYPLSIPASAH
GVPLVVTWMATLYCLFNGRLQVLASAGAAVAACPTGTATWSSACAPAYTPSMSFVRCWRK
RHELQSSFSASSVGAAAAHIAWWFLLFLYTVGVFGGSALFFAGQRINMQADYYLIALRRR
GEDNISDDRSKPVGQSAASLDGDVLVSSSSGVSRAAQQRSRGGGYRIPVSGWFDCVSCAN
FFGELVEWTGYVIVVSATSAASNGSCRSVATALEDELLRPLSSSSWWSLMNPMMWLRLVM
RVFCSGAESHPAALAAFSFLVYVFSNLAPRAVAHHAWYAKTFGDRYTRLGRKALLPGVY
>A4HXI7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania infantum|TrEMBL
MSADARIAIIAVVHLALTWVLLRYIADSAMPFYVHREGSSPAGAANGASVRRAVAHEWDQ
WSPFLVPSQEAYAAQLGRQQRATSAADAVALNSRVVWRSSAFHLTLAIFTYALLRFGVTA
PYGRHSWSLGFQLTLPSRVSWMLQESPTIFQVIYHVFLEYPRLMGHSPSWPSLWPSSSSA
SGPTAAGMPSSHSSADTCHSYWGCVRAACTQQHLGLLLFVIHYVHRSWLYPLSIPATAHD
VPLVVTWMATMYCLFNGRLQVLASAGAAATACATDTAAPSLACTPAYTASMGFVRCWRER
HELQSLPSSSASVGAVAVRVGWRLLLGLYAVGVLGGSALFFLGQRINMQADYYLVRLRRG
DKGSISHGGSKPVGRRAANLHGDALATSSSLEASRDAQHRSSIDGYRIPVGGWFDSVSCA
NFFGELVEWTGYVIVVAATSAASNGNCLSVTTALEEELLQPLSSSSWWSLMNPIMWLRLV
ARVFFGGSESRPAALAAFSFLVYVFSNLAPRAVAHHAWYAKTFGDPYTRLGRQALIPGVY
>G6FBN9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Lactococcus lactis subsp. lactis CNCM I-1631|TrEMBL
MNYIAVLVTLLLYFICWFLIATSKKNYGLIDIAWGGGFVLTAVVSYLFSPRITIQNSLIL
VLVILWGVRLAIHLGRRNWNKPEDYRYTNMRKRWGNNFPKLKAFLTVFMVQYLLLIIISL
PIIQVNSNVNSQFYWWQILGIIIWIFGFIFEVFGDRQLEVFKKLPQNKGKLLTCGLWSLT
RHPNYFGESMCWWGIFLISLTTLSTLWLVISPLLITSLLLFVSGVPILEKKYKNREDFKE
YAKTTPKFVPFIGKKGL
>A0A839S5N2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Prauserella isguenensis|TrEMBL
MPHREWDAEADVVIVGFGGAGACAAVDACDHGADVLVLDRFHGGGATAISGGVVYAGGGT
PHQRAAGFDDSTESMLEYLRLETDGVVSDETLSRFCAQSLDNLRWLEQHGAVFEGSMAPR
KTSYPTNEHYLYYSGNELAPPFSDAAAPAPRGHRAKGKGVSGKPLFAALRKAVARRPIAV
RTQTRATGLVTDGDRVVGVEATELRKSFPRWLHRALSAANRKLNIYYRPLGRMLDGPIAN
LERGYGEVRRFRARRGVVLAAGGFVFNRPLLAEHAPAYRRGSSLGTIGDDGSGIALGESA
GGRADRMHRVSAWRFFNPPLAMIDGVLVNNRGERICNEAYYGARIGDHVARQPDAEAYLI
IDARTRAEALRQVPSQTLWFQRLQAEYVLRLGNVSGGDLPTLARKRGIDPDGLARTIAEY
NAGAAAGRDRMGKDPAHVRALSAGPFHAIDCSIRTQPAFPIPMITLGGLAVDEATGAVTR
GDGSAVPGLYAAGRNAVGVCSESYVSGLSIADCVFSGRRVAAALTEKRFQEEQA
>A0A2M9UWU7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Bacteroides fragilis|TrEMBL
MSIESFNLLLLVMGLMALVVFIALYFVRAGYGMFRSRSWGISVNNKIAWILMEAPVFLVM
GWLWWHSDRRFLPVELTFFLFFQLHYFQRAFVFPFLMKGKSKMPVLILLMGVIFNILNGL
MQGEWIFYLAPSDYYTPGWLLTPCFWIGTLLFFAGMGINWHSDSVIRHLRAPGDTRHYLP
QRGMYRYVTSANYLGEIVEWVGWAILTWSLSGCIFAWWTVANLVPRADAIWHRYREEFGT
QVGSKKRIFPFLY
>J9GWZ2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|gut metagenome|TrEMBL
MEMTPSSFEFLLLTMSALAVVVFVALFYVRAGYGMFRSSAWGLSIDNRWGWVLMEAPVFF
VLLALWWGSEVRFHPAPLIFFLLFELHYFQRSFIFPCLLKGNSRMPLSIVGMGVLFNVLN
GVMQGEWLFYLAPEGLYSEAWLSTPSFGFGLLVFAAGMGINLHSDGVIRHLRKPGDTRHY
LPQQGMYRYVTSANYFGELLEWTGFAVLTASPAAWVFVLWTFANLAPRAHAIRNRYRSEF
GREAVGHRKRLIPFIY
>A0A852RL27|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Nocardioides kongjuensis|TrEMBL
MSDAVHDVDVVVVGFGCAGGAAALEARRTDASVVVLERASGAGGSSAQSGGELYLGGGTA
VQEALGFEDDADNMLAFLRAALGPHADEEKLRLYCEGSVEHFDWFCSLGLEFEKSLYDAP
SWLPPTTDGLMWLGENAWPYDELARPVPRGHRPATCGFGGWLVMDRLVAACASAGVVTAT
DTRAVSLVVESGRVVGVRARRFGDDVTYRARRGVVVTTGGFADNPEMLSAHAPDLLGHGV
VSDGGDDGSGIVMAQAVGAAVRRMSVVEVAYTALPALACRGMLVNARGERFVNEDVYPGL
FSHAALHEPGPCWVVVDGQALEEVDEADLWGTVPSYAAETIEELESDLGMPPGALARTLA
GYNDGAARGGDPLFHKNARWTRVLTGPFAAIDPRIGFHNPTHRAAPGATGFAGFTLGGLH
TTVDGAVLSLGGDPIPGLYAAGRASSGMHGQGYVSGTSLGDGTFFGRRAGRAAAQSR
>K1THT0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|human gut metagenome|TrEMBL
MNQETFQIFLWVMSAVALVVFIALYFVKAGYGMFRTASWGISINNKLAWVLMEAPVFIVM
FGLWGKSGAGFAVPVYFFFLLFQLHYLQRAFIFPFLLKGKSRMPVAIMAMGIVFNLLNGM
MQAGGLFYFAPEGLYADGWAYLLKPHALLGIILFFAGMFVNLHSDYVIRHLRRPGDTKHY
LPGKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWTFANLVPRADAIHRRYREEF
GDEAVGKRKRIIPFLY
>A0A375HFD6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Cupriavidus taiwanensis|TrEMBL
MHPDSVTPVYAPLRLDDPDAHPWQAACDAVVVGFGAAGACAALEAAQGGARVIVAERFEG
GGASAKSGGVVYAGGGTSYQAAAGYADTPQAMADYLRQETGGVVSEAALQSFCERSRDML
AWLEGLGVRFAATVPPRKTSYPAQPYYLYYSGNEAVPAYARHATPAPRGHRVKGPGMSGR
TLYGVLRGAVEARTDITVMRQTAARRLIVDKNGSVIGIELWQVPPGRHQKRHARLARLAE
RLHNAMPGVADLLRRRVLQLELRHAQPVAVRTRAVVLATGGFIFNRAMVARHAGKYLQNW
RLGATGCDGSGIRLGESAGAAARHLERVSAWRFINPPFDWGRGCVVDAQGARIGNEETYG
ATLGHAICERHGGRAWLILDRALARAALRECLGGRLWAFQALPAAMLLLAGATRASSIEA
LAGKLGMPAAALRATLDAYSAAARGEIPDPAGKSAPMCASLETGPWVALDISANSRVFPC
PAITLGGLSVEESSGRVLAAADGASEGAPIAGLYAVGRTAVGIASNHYVSGLSLADCIWS
GRNAGRHLAQQPAGHPIGGQQAHTHQETTHEPTY
>A0A7Z7N7D3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium simulans|TrEMBL
MFTVVQVLRRVGVQTRTLAGCLQLDPVTVDESADVVVVGFGAAGACAAIAAREHGAEVIA
LDRANGGGATAMSGGIIYAGAGTTIQRQAGVRDSFEQMLTYLRLEVGDAVSEATLAAFVR
DSPEMIDWLIKYGVPFDSTLCPYKTSFPNNRYYLYHSGNENAGAFRCHTPPVQRGHRVKG
RGTSGKKLYGPLAKSALALGVRLRPHTVVTRLVQDSSGRVTGVDAMTMNHAPPRIRRLYA
ETAALSAKPGIYYPPLRRLMEHRLRKLEQRYARPVRINARRAVIICAGGFIANTEWIQRF
APQYSNGLQLGTSGDDGSGIALAQSAGAVVERMDNISAWRFITPPSAFISAIIVDELGRR
IIDESRYGAAVGQAMVRNHGGSGWLLADAALMREARRQMIKQPLWFQRAQSTALIYADSV
KAPSLRAVALAAGIDPEGLSATVKAHNDAFDSEAPDPAGKPAEFVRPISQPPYTLLNISV
RRSLLNPTPMLTLGGVRVDEDTGAVVDESGKPIPGLFSAGRTAIGICSNSYVSGLSLADC
VFAGRRAGMHAAQTASG
>S8G9W2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii (strain ATCC 50611 / Me49)|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQERETKASIVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLPEKNDTPVSALLSNASPDSIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPTIACLSFVVATMTVNASKTHTWYRRTFGDAYPQNRRALLPLVY
>A0A086L5E3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii p89|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQERETKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLAEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSYLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPTIACLSFVVATMTVNASKTHTWYRRTFGDAYPQNRRALLPLVY
>A0A840ITJ1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Amycolatopsis jiangsuensis|TrEMBL
MDELGADVVIIGAGAAGACAAIEAADAGAEVLLVDRFAGGGASRVSGGVVYAGGGTPQQS
AAGVEDSVDAMHAYLRMEAGDVVSERTLRRFCEESVGMIAWLERQGVPFEGSLCGYKTSY
PSNKHYLYYSGSEASGGFRDVAKPAPRGHRVKGPGTSGKLLMERLLATARARGVRMLPQT
RVTDLVRNADGAVTGVLASSLRSAPGWARARHARLSSWSAKPGIYLPQLRRSLHRRVTRI
EQKHATELRITAGAVVLAAGGFIANRELVREHAPAYRGGLALGTSADDGSGLRLGLAAGG
RAAELDRISAWRFLTPPAAFLGGLLVDADGRRIIDESRYGAAVGERMITGHGGRGWLLVD
APIVTEARREGRRQGQWFAALQLRYLLGPGRVSGRTLEEVARKAGVDPDGLVATYAQYRQ
GPDPVGKPAEFARPLDTPPYSLIDVSVKPNLGYPCPMITLGGLVVDEDTGAVEGTRGLYA
AGRTAVGICSRSYVSGLSLADCVFSGRRAGLHAAKPAGSVDKNENVF
>A0A139Y0K6|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii ARI|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A7W5AI41|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinoplanes campanulatus|TrEMBL
MDESATVVVVGFGAAGACAAIEAAEAGADVLVIDRFTGGGATAISGGVVYAGGGTRQQRA
AGVTDSPSAMYAYLRHEAGDAVSPATLRRFCDESADMLAWLEDHGVPFDARLCPYKTSYP
TNRHYLYQSGSEHAHPDPAPRGHRVHAPGTSGGTLHTRLATAARALGVRFLPQTEAVSLI
LTPASAPSAPSSAPSAPPSAPPPLESFAVEPSSTAEPSPVPQRETAAAGADHAEGRVVGV
ECRTLRDAPAWARFAHRRLHRWSVKPGLYLPGFGRAMHRLAARIDNRHGRTLRIHAGAVV
LTAGGFVFNREMMREHAPGYRGLRLGTPGDDGSGIRLGTDAGAGVRHLGRVTLWRFLTPP
SALLGGVLVDRDGHRFCDESRYGAALGDAILHRPGGRAWLLIDATVLAEARRQLRSQTLW
FQRLPTWWLLTIKRLRAATLDRLADRVGIDAPTLATTVTANNTTALRIGPSNPTASADVV
ALASGSGAGDVDVVAFGSEADAPIPTVSADVVAVASGSEADAPIPGTRDGDAAVSGAVEC
DEFGKPLALVRPLIRPPFSLLDVSLRASPAPMLTLGGLTVDEETGRVLRPDSTEIPGLYA
AGRTAVGICSGSYVSGLSLADCVFSGRRAGRDSAATSPPAPRRSWVPVHRGRWSIAQDRQ
GISEPAPEPETPARHTGADSSDPTRPASRSSGGGQGDERARRH
>A0A5E6ZVA0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATFDDSFCTPIQTPLQVADSSALLWDEHCDVLIIGWGAAGACSALEARALGADVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVISDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPQHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKDACLRAGARPLLQAAAKRLVVDAQGRVVGAEMWCITPGTPQAQLHARLA
ARAERLQNFAAGYCNKLRQRIGQLERDFARPRLVHARNGVILSTGGFIFNRELIKRHAPK
FERNFKVGATGCDGSGLRLGTSVGGQGAALERVSAWRFINPPYSWHKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSLPALVLMLFKVRKG
QHLSQLATNTGMNPAALRESVLAANAAARGEAPEPFGKSPGGRQVLDQGPFYACDISVTN
PVFPLGALTLGGLRVDEGNGAVLDGQGQAIPGLYAAGRTALGIPSHLYISGLSLADCVFS
GRRAGAAAARFMDQQLQPTLAQETT
>A0A5E7J2P8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATFDDSFYTPIQTPLQVADSSALLWDEHCDVLVIGWGAAGACSALEARALGANVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVISDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPQHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKDACLRAGARPLLQAAAKRLVVDAQGRVVGAEMWCMTPGTPQAELHARLA
ARAERLQNFAAGYCNKLRQRIGQLERDFARPRLVHARNGVILSTGGFILNRELIKRHAPK
FLRNFKVGATGCDGSGLRLGTSVGGQGAGLERVSAWRFLNPPYSWHKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKALREALFGGYWWFQSLPALVLMLFKVRKG
KSLSELANATAMDPAVLRASVLAANAAARGEAPEPFGKSPGGRQVLDQGPFYACDISVTN
PVFPLGALTLGGLRVDEGNGAVLDGQGQAIPGLYAAGRTALGIPSHLYISGLSLADCVFS
GRRAGAAAARFMDQQLQPTLAQETT
>E9AR82|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania mexicana (strain MHOM/GT/2001/U1103)|TrEMBL
MLACARITIIAIVHLALTWVLLRYIADSAMPFYVYREGSSSAGAANGASVRTTATYERDQ
WSPFLVPSQEVYAAQFARQQRATSAAEAVALNSRVVWRSSVFHLILAIVTYALLRFGVTA
PYGRHSWSLGFQLTLPSRVSWMLQESPTIFQVLYHVFLEYPRLMGHSPSRPSLWPSSFSA
SSPTAAGMSSSHSSADTCHSYWGCVRAACTQQQLGLLLFVIHYVHRSWLYPLSIPATAHD
VPLVVTWTATLYCLFNGRLQVLASAGAAVTACATDTAAWSSACTPAYTASMSFVRCWRER
HKLQSLSSSSAGAAAVHVGWPLLFCLYVVGVLGGSALFFVGQRMNMQADYYLVRLRRGDK
GCIGHGGSKPGGRRVTNLHGDALGPSSSSSAASGATQHRSRVDGYRIPVGGWFDSVSCAN
FFGELVEWTGYVIIVVATSAASNGSCLSVATALDEELLRPLSSSSWWSLMNPMMWLRLVV
RVFFSGSESRPAALAAFSFLVYVFSNLAPRAVSHHAWYAKTFGDPYTRLGRKALIPGVY
>A0A7W7CHG4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Crossiella cryophila|TrEMBL
MSTAWDDRAEVVVLGFGAAGACAAIEAAAGGADVLVVDRFSGGGTTAISGGVVYAGGGTK
IQSAAGVGDSVEAMHAYLREEVGDAVSPETLRRFCATSADHLEWLRRQGVPFEGSLCPYK
TSYPDNRYYLYFSGSENSGAFRRYAVPAPRGHRAKGPGTSGATLFTALAESVRCQGARVR
TQTTARRLIVERGRVTGVECRSLDRAPGWVRLAHRVLSRYAAKPGVYLPWLRRLLHGRVA
GLERRHGRRIRIGATTGVIIAAGGFAENREMLREHAPDHRGGLALGTPGDDGSGIRLGVE
AGAATALLDRVSAWRFLSPPSALLSGLLVDRDGARVIDESRYGAAVGEALISRHRGRGWL
LVDAAILAEARRQVPRQALWFQRVQAYAQLAARVTGPTLESVAARAGVDPAGLRATVRAH
QDRVRRRAADPTGRPAELSRELRPPFALLDMSIRNRLNPCPMLPLGGLVVDERTGAVRRP
DGSAIPGLYAAGRSAVGLCSRSYVSGLSLADCVFSGRRAGAHLAATRRSGAHR
>A0A364NC04|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Stemphylium lycopersici|TrEMBL
MFTLPRELGIDELPWGNWTMAGCFVIHYLYRAVLAPLFLNPSMSPMHPLVWLMAFGFQMF
NAISIGGYLAGYGPTSPYEWGARSEWMFVGLVIWCWGLMANMFHDDDLREIRRSADRKQR
KEAKEQGKPMESVDKIYMIPKNGLFKYALHAHYFCEWIEWAGWWMIGGWQCHPARSFLFN
EISTMLPRALQGKRWYEKKFGKEKLQGRKAVIPGVI
>A0A086L162|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii FOU|TrEMBL
MNSLPSALAFGVILSLAIPVVSVACLDPLLLSPFFLFCLSWTAVLCFLAAAVLAVLSLVL
PYSLGALAAHGKVRLSLSSTGSGTEARVTEKCSQSLAQLPLQRDARTRPENAKDEQRRWG
LQRERNDACGDREEARREVGEEEEAEGQAACRDKAPQREPRSEAAGGEESEAEATGASQV
AVEDQQERETKASFVRNCADGMLKALAVPVQKSLFLHFYLLGAGLSLAMALLLSLALRRC
RLSLAEKNDTPVSALLSNASPDNIPQGPSSNGQRGKSDLGRLVNEAAAGMATDADLLLPL
LLFFLHCLRRLLEQLFVVRTHATASQMSLAAYLLGLSFYVGTPLSLLLGSLGSFLSSQPL
PSCSANAFPLSLEASPALFAASIQHVGEALVARATSPPGSVGMTFAAFLLVNCMQLHSHM
LLARLRPADSAEGRERFLDSSASKTIHPSLRDASGAYSIPRGGCFAFVSCPHYLAEILIY
LCLCLLLPSPPT
>A0A0G3V3G7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinobacteria bacterium IMCC26256|TrEMBL
MSTNDSLGEATDAAQDAVLPIAPLDAAEVTQWDIETDVAVVGLGIAGTCAAISAHEAGAR
VAAFERGGAGGGTSALSGGLIYLGGGTPIQEACGYTDTAENMERFLLEACGPDADADKVH
AYCQGSVAHYNWLVDHGVPFKGEFCDEPNREPITDAGLCFSGGEDSWPFNTIADVVPRGH
HPQFPDTAGGFLMECLTGALAKTDVAVHTDARVERLIVDAGRVVGLVARVDGRDLHVRAT
GGVILCAGGFIFNEEMLARYCPEALRPFSAWRVGTDNDDGRGIRLGEGAGGTTTRMDSVE
CALPIGPPHRMARALLVGKDGKRFINEDTYTGRIGHRALVDQQGEIYMIVSEEIFEVNFV
GMRITWAAETPEELAADVGLPADALAETIATYNQHAENGTDPEWHKEPDFLVPLRPPYGA
IDLRVDSKAIYAPFTLGGLNTDPDSHVLDPSGVPVPGLYAAGRSTAGIAAHGYVSGISLG
DGSFFGRRAGESAARDK
>A0A498PN49|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium attenuatum|TrEMBL
MAGDKSARICESADVVVIGFGAAGECAAIAARERGADVIALDRANGGGATAIAGGIIYAG
GGTTVQQQAGVKDSPEQMLAYLRLEVGDAVSQETLESFVRSSPEMIDWLSSYGVPFSPAS
CPYKTSFPNNRYYLYHSGSENAGAFRCHTPPVQRGHRVQGRGTSGRKLYEPLAKAALALG
VRFWPQTTVTNLIQDSSGRVTGIDARTMRFAPAPVQRLYAAAAKLSTKPGIYYPPLRRLM
EGQLRRLERRYAQPVRIDARRAVIVCAGGFIANTEWVQRFAPQYVGGLQLGTSGDDGSGI
ALAQSAGAVTDRMDNVSAWRFITPPSAFIGAVIVDRGGHRVIDESRYGAAVGQAIIRQHD
GAGWLLADAALMREARRQMITQPLWFQRAQVAALMLADAVTAPSLPEVAKAAGIDPDGLV
ATVAAHNAAIDAGAPDPAGKPAEFVRRISQAPFTLLNISVRPSLLNPTPMLTLGGIRVDE
RSGAVVNESGEPIPGLFSAGRTAAGICSNSYVSGLSLADCVFSGRRAGAHAAAAPAEQSS
R
>A0A178X8C3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Amycolatopsis sp. M39|TrEMBL
MDELGADVVIIGAGAAGVCAAIEAADAGAEVLLVDRFSGGGASRVSGGVVYAGGGTPQQR
AAGVDDSVDAMYAYLRMETGDVVSERTLRRFCEESVDMVAWLERQGVPFEGSMCDYKTSY
PSNKHYLYYSGSELSGGFRDVAKPAPRGHRVKGPGTSGKLLMKQLLAAARERGVRVLPQT
QATNLIADDSGTVTGVLTRSLRGAPSWVRARHARLADWAAKPGIYVPAMRRSLHQRVERI
ERKHARELRISARRGIVLAAGGFIVNRAMVREHAPAYRGGLDLGTSADDGSGIRMGVEAG
GRTAELDRVSAWRFLTPPSAFLGGLLVGADGRRIIDESRYGAAIGERMIAGHGGRGWLLV
DEPIVAEARRDGRKQGQWFATLQLRYLLGKGRVSAGTIEEVAARAGVDPAGLAATYAEYQ
RGPDPAGKPADFARPLDTPPYSLIDVSVKPNLGYPCPMLTLGGLVVDEDTGAVAGVRGLY
AAGRTAVGICSRSYVSGLSLADCVFSGRRAGLHGARGADRVDKNENVF
>A0A852RGW1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leucobacter aridicollis|TrEMBL
MRHPYDLIVVGFGAAGAAAAIEAADAGARVLILDRAHGGGASTLSGGVVYAGGGTAQQRA
AGIDDTPEDMFAYLTQEVGDAVSESTLRRFCEQSVGTLEWLETLGARYEGSLAPYKTSYP
SDKHYLYYSGNENAWPYRERARPAPRGHRTVARGMSSGAALFRVLRRAVESRSIQVVRAA
RVDELIMEDGAVVGARYGALTDPADLAAHARILRRGAKLGNFAPALGAVFDRQAARLWRG
RATRAQATGARVLLSGGGFVMNAALMDRHAGPYRNVNPLGTAGDDGGAIMLGVEAGGSTG
KMDRLTAWRFLTPPSALLGGVAVGMDGKRIANEDLYGATFSDSLLRNHEGKGRLVLDASQ
WRAAKSQVRAQSQIFQALQALFLFTLGHRRAATLASLARRTGVSVAGLESTVNAYNSGIS
GEGDPAHKHADIATPVARGPFYAIDISVGSSPFYPVPGLTLGGLRVNEETGAVLREGGGE
VTGLLAAGRSAVGICSNSYLSGLSLADCLFSGRRAGRTVAAALAPAG
>A0A5P9PIZ1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Amycolatopsis sp. YIM 10|TrEMBL
MQADVVVAGFGAAGACAALAAAEAGADVLVLDRFSGGGATAISGGVVYAGGGTAQQRDAG
VSDSVDAMYAYLRLEAGDVVSERTLRAFCEGSVEMIRWLEGHGVPFEGSLCPEKTSYPGN
RHYLYYSGSEASGAFREVAAPAPRGHRAKGRGTSGKALFKPLAAAVRRRAKVLPQTRVRR
LVQSGDGTVTGLIATTLRDAPGWAKTLHRVLGQWSAKPGIYVPALRKLLNRRVTAIEERF
AREIEISARSVILTAGGFIANRDWVREHAPAYRGGLQLGTAGDDGSGIELGRRAGGATAE
LGRVSAWRFLTPPSAFLGGLLVNERGQRVIDESRYGAAVGEELITRHGGRGWLLLDEELI
RRARAQGDLQWFQRLQTLYLLKRGRVTGGSIAEVARRAGIDPDGLAETVAAAAAIPDPTG
KPADFAHRLGEPPYSLVDVSIRPSLAFPCPMLTLGGLVVDEDSGRVLGDDRRPIPGLYAA
GRTAVGICSRSYVSGLSLADCVFSGRRAGNHSGRTLRELDKNENVF
>A0A5E7DVC5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MATFDDSFCTPIQTPLQIADSSALLWDEHCDVLIIGWGAAGACSALEARALGADVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFSDTPEAMFDYLKHETQNVISDDTLRRFCADSV
SNLDWLESHGAPYGHQMPPGGKTSYPPDGYFLYYSGNELVPQHGGPLPPAPRGHRTVGKG
QCGAVLYAHLKTACLHAGARPLLQAAAKRLVVDSQGRVVGAEMWCMPPGSPQAKLHARLA
ARAERLQNFAPGYCKKLRERIGQLERDFARPRLVHARNGVILSTGGFIFNRELIKRHAPK
FERNFKVGATGCDGSGLRLGTSIGGQGAGLERVSAWRFLNPPYSWHKGIVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSLPALVLMLFKVRKG
QHLSQLATATGMNPTALRESVLAANAAARGEAPEPFGKSPGGRQVLDQGPFYACDISVTN
PVFPLGALTLGGLRVDELNGAVLDGQGQAIPGLYAAGRTALGIPSHLYISGLSLADCVFS
GRRAGAAAARFMDQQLHPTLAQETT
>B0EQD7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Entamoeba dispar (strain ATCC PRA-260 / SAW760)|TrEMBL
MNNENIYYLFLLIMLIIGFIVFILLHYITVGYGMFQNNKWGLTINNKIGWCVMEIVSMIG
IIIFYIYSSMNEIIPMISLILFIIHYFRRSIIFPLRISKGGKMPIIIMLMGMLFNLCNCY
AQAGWLFFYHPPYYYLRWFNTPQCYFGLLFFFIGMVINIHSDEIIRSLRKEGETEHKLPQ
GGLFNYVTSAQYFGELVEWLGFSIFTLSPGAILFFFWTFANLTPRARSIHLAYRKKFKNQ
VGKRKILIPFIY
>A0A380ZCE9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Bacteroides eggerthii|TrEMBL
MSEEGFHLFLGAMCATALFVFIALYFIKAGYGMFRTASWGYSINNKLAWVLMEAPVFIVM
FWLWGRSGVGFSVPVYLFFLLFQLHYFQRSFVFPFLLKGKSRMPVAIMAMGIVFNVLNGM
MQAGGLFYFAPEGLYAGGWAYLLKPHALLGVLLFFAGMFINLHSDHVIRHLRKPGDTRHY
LPAKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWTFANLVPRSDAIYRHYRAEF
GDEAVGKRKRIIPYIY
>A0A125YRT9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii (strain ATCC 50861 / VEG)|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A653BC57|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas oleovorans|TrEMBL
MEGMQALRVSSAAQLDWSERCGLLVVGFGAAGASAAIEAAERGLRVMALDRYTGGGASAL
SGGVVYAGGGTPYQQQAGYQDSPEAMFAYLRQEVGDAVSEATLRDFCLHSCEQLAWLERQ
GVAFEASMPPHKTSYPSDQYYLYYSGNETLADYARHASPAPRGHRAKGEGLSGAVLYAAL
AASAQRVGVRLYRQCQARRLVLDANDRVIGVEAWQLAAGSPAAHRHARLSRWAQALHMYA
PVLAERLRARARKIEQAHAERRLIRAERGVLLSAGGFVLNREMVQRHAPAYLAGLPLGGA
GCDGSGINLGRSAGGSTARMDRISAWRFINPPQAWAQGLIVNARGQRYCNEEAYGAKLGH
LMVEEHGGRAFLILNHDLVCKALRQVGPGRVWQFQRLPVLLNLLCNAKRAHTLERLGARC
GLPERELKASLEAYNATARGERADAFGKSPAMLADLSKGPWYALDLSFACRLFPCPTISL
GGLRVCETSGRVLDDNGVAIAGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAAHMAT
TVTQQAQ
>A0A7W7H741|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinoplanes octamycinicus|TrEMBL
MTETADVLVVGFGAAGACAAIEAADAGARVLVLDRFGGGGATAISGGVVYAGGGTRQQRA
AGVRDTPGEMADYLREEVGDTVAAGTLRRFCEQSAGMLDWLAGLGVPFDARLCPYKTSYP
TNRHYLYLSGSETAFGQSAARGHRVLARGTSGRLLHRRLAAAVRDRGVVVRTQTRAERLV
TDADGRVTGVECRTLTGWARLGHRVLHRWSVKPGLYLPGLGRALHRPVAWLERRHGRPLR
ISAGSVILCAGGFVFDREMMREHAPDYRGGLRLGTRGDDGSGIRLGVAAGGATAHLDRVS
VWRFLSPPSAMLDGLLVDRDGRRVGDPARYGAAVGEAILRSPGGQAWLLLDAATLARCRR
QVWSQTLWFQRWQALWLLTFGHVTGRTLAAVARRAGVDPAGLIATAGPATGPPPYVLIDV
SVRNRTAFPAPMLTLGGLRVDEETGQVLGVPGLYAAGRTAVGICSRSYVSGLSLADCVFA
GRRAGRSAAAVPDRGGRHADRR
>A0A2S8BQT5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacterium talmoniae|TrEMBL
MNISVRPKLLCPTPMLTLGGVRVAEDTGAVLNAAGDPIPGLFGAGRTAVGVCSESYVSGL
SIADCVFSGRRAGASAATG
>Q4WNY1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)|TrEMBL
MGSAFSTFMGSLPPLRDLILPTPQAYTTLLNIFQYFPVFSLVQWAVSWHPAGKGSYQRSW
LNIPGKLGWFLMEIVGPANLLYILYKLPPALNITSLPLSNKLVASLYVIHYVNRAIISPF
FAAPSMSPMHASVVSMAVLFNWLNSTCLAGWLVGYHVPVLGYKTDGAVSGVPGGPSSYSA
ATHFLPCLGMVLFAAGMIGNIHSERTLFHLRREAAEKRDAAEKSDEDITQHGDEDHPTFI
QASSSSSSTDADANANAKGRKNKYDKVYVIPPARGVFRSILYPHYAFEWLEWLGFSLVGT
AVFPAAQALAYASPPLPIAPWLKPAAALAETLQVPLPLPAVVFVVNAVANMLPHARWGRK
WYVEKFGEKAVAGRGAAVPWCPWL
>A0A5P9C9R9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas sp. THAF187a|TrEMBL
MENVQASSALRVSSAAQIDWSERCGLLVVGFGAAGASAAIEAAERGLRVLALDRYAGGGA
SALSGGVVYAGGGTPYQQQAGYQDSPEAMFAYLRQEVGNAVSEATLRDFCQHSCEQLAWL
ERQGVAFEASVPPHKTSYPSDQYYLYYSGNETVADYARHASPAPRGHRAKGRGMSGVVLY
AALAASAQRAGVRLYSQCQARRLILDANDRVIGVEAWQLAAGSAAAHRHARLSRWAQALH
MYAPALAERLRTRARKIEQAHAERRLIRAERGVLLSAGGFVLNREMVQRHAPAYLAGLPL
GSAGCDGGGICLGLSAGGSTARMDRISAWRFINPPQAWARGLVVNAFGQRCCNEEVYGAK
LGHAMVEEHGGRAFLILNRDLVCKALRQVGPGRVWQFQRLPVLLNLLCNSKRAGTLERLA
ARCGLPERELRASLEAYNAAARGECVDAFGKSPAMLSDLSKGPWYALDLSFACRLFPCPT
ISLGGLRVCETSGHVLDDNGVAIAGLYSAGRNAVGVASNLYVSGLSLADCIYSGRRAAVH
MATTTTRPAQQTKRRTT
>A4HEG5|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Leishmania braziliensis|TrEMBL
MKVIVASGQDGSRKHEVELAANATLADLKKAYRSEVDVHRKSFKVPGPIAAGGSAPTADG
TKPRPNLITLSEKMPLSQQGVKDGTVITYKDLGPQIGYRTVFYVEYAGPIAFMLLYAMRP
SFIYGSAPMPAYGYTQKLYIGLFITHFLKRELESMFVHKFSHPTMPMRNIFKNCIYYWSF
AAFIGYVLCSPFFTATSAAQSNFGAVFMVINELLNFAVHYQLSTMRKSDGDTTRNVPQGP
LFALVSCPNYFFEIMSWVSFSIGTNMLSSWFFTLAGFVQMADWAKKKHRGYIKADPANKK
KAAILPFLM
>A0A2T6IK71|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii TgCATBr9|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KVLLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A7W7IHX8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Actinomadura catellatispora|TrEMBL
MATSSVEPVGASETAFDHECDVLVVGAGAAGAAAAYESAAAGADVLVLERSSGPGGTSAQ
SGGELYLGGGTRVQKACGFDDSPDDMYAFLLAALGPHADAEKLRLYCDGSVEHFEWFRAR
GVPFKESLFDAPGWMPYTDDGLMWLGENAWPYNTIARPVPRGHRPEAPMFAGGILMEKLI
AAAAEAGAVTHEDTYATNLVVDGGRVVGVVARRFAETVAYRARKGVVLTAGGFVDNEEML
ADHAPVLLGHDKISDGTSDGSGIRMASALGAATRRMGSVEIALTANPAVVCRGMLVDGLG
RRFINEDVYPGLYSHRAVQHQPGPYWAIIDETGHDEIAEADMWGVRPKHAAETLAELEES
LGLPPGSLEATVETYNRFAERGEDPYFHKDPRWLRPLKGPFAAIDPADGFFGAGRHGAGT
GAGGFTLGGLDTTVDGEVRDVSGRPIPGLYAAGRTAAGIHGEGYISGTSLGDGTFFGRRA
GRAAAQNP
>A0A0F0L7Z7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Microbacterium oxydans|TrEMBL
MTSGTFDLIVVGFGAAGVAAAIEAADAGATVLAIDRGFGGGATALSGGIVYAGGGTRYQK
AAGVDDDPGNMFRYLTQEVRGAVSDDTLRRFCDESAETISWLERQGASFQASLAPFKTSY
PTDRHYLYYSGNEKAHPYKKHARPAPRGHRQIAKGLGSGKVLYSRLKASALKKGVVFLPH
TTVDELIVEDGTVVGVRYRSADERNLPASYARRSVLAAKAGNWAPAIGERVAATLHRDWE
GAARPGEARGHAVLLSGGGFVHNPEWMKKWSGPYRDISPLGTAADDGGVISLGLTAGGAT
DHMDRMTAWRFINPPSAMAEGVVVDGAGQRIANEDLYGATFADHMVREHDARGYLILDSK
QWRKARRQIRTQTNSFQLLQLLYLYTIGHRKGRDLSALARKLDLPVNATAATITAYNSGI
LSGAGDPAGKAPELSSTVMSGPFFAVDLSVKNSPFYPAPGLTLGGLKVDEQSGGVLTESG
QVIPGLFAAGRSAVGVCSVGYISGLSIADCFFSGRRVGRIVARAVEGTADPAESAAL
>X8DQJ7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mycobacteroides abscessus subsp. bolletii 1513|TrEMBL
MLTELYHTAIVFLVALAVVTFVSGFWFTNPYGRFAKPDETFTAPAKLGWLIFECPQWWAF
TVTFWTVAHHHGAPALMLYGLWQCHYLYRGLLYPLWRKDSGKRFPYSGIAFGFLFNAING
FANGYAVACAAHLQSGAWFTDPRFVFGVLIAVVGWIVNFQADRILINLRSDGFGGYRIPY
GGAFRWVSAANYLGEIILWAGWALMSWTLPGLIFVLFSIANLLPRALSIHRWYRQTFPIE
YPRERKAIVPGLL
>A0A1D3LIV7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Plasmodium chabaudi adami|TrEMBL
MKVILRKRNGKFIDCFDISPSTTVDKFKELFYIKYHYYPERQKWNLDNATGKTLVSGTLS
EIGIKDGDILIFKDLGVQISWRLVYVIEYLGPILIFPFFYFCDKYIYSHSAKNKHIIQIL
SLWFLLFHFLKREFESLFVHRFSNATMPIVRVPINCGHYWILCGVNIGYYLFHPKYKPYN
LGSKPHLVYYIFFVLLVLEFLNLKCHLILKNLRPRGTKTRGIPYGYGFNYISCANYFYES
LIWIIFSLITNTLTGYIFCCVAITQMAIWALKKHNSYKKEFPHYPKNRKAIFPFVL
>S7UUW0|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Toxoplasma gondii (strain ATCC 50853 / GT1)|TrEMBL
MAFSLPGMVLERALSVTRSLLKMLTKFLLQEPAAEHVEVDKSGVYLFWAAVGLAAFGLVT
VVGQIFIRAPWGKFRNDAKSRVWGPSVPCAVAWMIQECPSFFIPFSVLVGTEWLAGRPIN
KILLVLFTTHYAHRSLVYPARLYVHTRYQENQSMPLGISAMAVLFCTYNGMIQSWSAISF
DYSSELDPFLAPRASVDDCSAALRLISGVCVFLWGMSVNIRSDYILMKLRVTSDRITPNP
VLSASAYRIPEGLWFNYVSCANYFGEICEWAGYAIACNTYVALSFAVFTLCFLTGRGVQV
HRWYLQHFEERYPSGRKAVIPFIV
>A0A173L044|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Sphingobium sp. EP60837|TrEMBL
MTEISLHRPYPAAKVQQWDFETDVAVIGFGATGACAAIEAAQGGARVMLFERGSGSGGAS
ALSGGEIYIGGGGGTDAQRAGGFKDSTEDLAAYLKAAGGPCADEAKCDLYAQESLNHYAW
LKEQGIPYRGNFLPGKHIEPTDDSTLIWSGSEAAWPFCNIAKPAPRGHVIAHMGWGGGRP
LIDILEARARSLGVEVTTDARAVALVQNEDRRVVGVVVRIDNVNRFVRAARGVVLATGGF
AFNEAMRRRYCPETFKISSPIGDQDDGVGIELGVGAGGDAIHMEQFFTTCPWTMPEPQAH
GVFVNQAGQRFINEDCYHGRVSRVAVDQMGDQVYLLLDIAHFDEPLPMAAMTIAGTGETW
EEVEAELEMAPGTLSATMTFYNAHAREGRDPLFHKLPPILKPLEHGPFVALELNFATSYF
SFFTLGGLRTSTDGEVLDRAGAPVAGLFAAGRCTSGLPAWGHGYSSGLSLADCTFFGRQA
GRNAAKG
>A0A2C8EVM3|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas lundensis|TrEMBL
MSRPAAQHTSNTDILAPLRERDVAEDAWHDSCDVLVIGWGAAGACAALEARAHGAQVIVA
DRFTGGGASAKSGGVVYAGGGTRQQRAAGFDDSPQAMFDYLKHETGGVIRDDTLRQFCAD
SVSNLNWLESHGATYAHSVPPGGKTSYPSDGYFLYYSGNELVPSHSGPQAPAPRGHRTVG
KGQCGAVLYGHLQDACLRAGVQPLLQAAARRLVIDDAGSVIGAELWRLPTGSREARQHAR
LAARAERLQNFAPGYCDRLRQTVSQLEREHARPVLIRARKGVILSTGGFIFNRDLIREHA
PKFRRNFKVGATGCDGSGLRLGQSVGAQSDRLSRVSAWRFINPPFCWPKGIVVNTEGRRF
CNEEVYGATLGQPLCEEQGGKAWLVLDARLRKQAIRQALFDGYWWFQALPALALMLLKVR
KGRDASQLAAACGMHGATLESALQAYNAGARGTAPDAFGKSPGSRQVLDQGPFYACDISV
SNPVFPLGALTLGGLKVDERTGAVLDGHGQPIAGLYSAGRTAIGIASHLYISGLSLADCV
FSGRRAGKAVAIGTQARSFAHDVASLG
>A0A6I6MKP4|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Terricaulis silvestris|TrEMBL
MTPITVGAAEDVDWDDSADVVIVGYGGAGACAALSARENGADVLIVDRFGGGGTTAFSGG
VIYAGGTRFQREAGYEDNAQQLRDYLAIEVGQVVKPETLARFCEGSAADVEWLVSHGVEY
ASDVFLEKTTFPPEGKYLYFSGNEKTPANAVRTPPIPRGHRAVGAGYGGQYYFAALSKAV
DRSGVRVRRHEKASSLVVDRAGRVVGVEVMSVPEAHRAEHQALHAKASPSLPHNNKAVER
LRQAAIALEEKVVEPKRIRARRGVVLTTGGFTFNQDMLRGVDPSFARHYLKLHNLATLGN
DGAGVALGQSAGGAIGRMDQLYIARNIAPPEAAVEGVMVNQEGRRFVNEDAYTSAVGGAI
AKQSDCRAWLILSPKSFWTAVRQAMFCGWHRFKFFGLPSLINFALGGTKRASSIRGIARA
CGVNEAALRATLSAHDRAIAEQRTDPGGKNEAYCAPMGEGPFYAISMSLSNGFALTPFMT
LGGLKVDEETGAVVREDGAPVAGLYAAGLCAVGLHSNGYISGISLADGVFSGRRAGRSCA
LSPSRAGHPLPETLPL
>A0A5E7ILJ2|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Pseudomonas fluorescens|TrEMBL
MSMSDNIPSTEVLAPLQVADSNSVTWDEQCDVLVVGWGAAGACAALEARAHGADVLIADR
FTGGGASAKSGGVVYAGGGTRHQQAAGFNDSPEAMFDYLKHETRGVVSDDTLWRFCSDSV
SNLQWLESHGAPYAHQMPPGGKTSYPPDGYFLYYSGNELVPTHGGPLSPAPRGHRTVGKG
QCGAVLYAHLKAACLKAGARPLLQATARRLVIDPQGRVLGVELWCLPEGSKEAQLHARLA
ARAERLQNFAAGYCKKLRQKVCQLERDFARPRRVQARNGVILSTGGFIFNRQLIEQHAPK
FRRNFKVGATGCDGSGLRLGASVGGQGSGLERVSAWRFINPPYSWHKGVVVNREGRRFCN
EEVYGATLGQPLMEEQGGKAWLVLDAPLRKKAIREALFGGYWWFQSFPALALMLFKVRKG
KSLSELASATSMDPNVLRASVLAANAAARGEAPEPFGKSEGARQVLEQGPFYACDISVTN
PVFPLGALTLGGLRVDERSGAVLDQQGQAIGGLYAAGRSALGIPSHLYISGLSLADCVFS
GRRAGAAVARPHGQQPHATHTREMT
>Q71VC1|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Rattus norvegicus|TrEMBL
MELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQELPSM
AWPLYEYIRPA
>A0A840PH70|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Thermocatellispora tengchongensis|TrEMBL
MNGPAAPMPAERVTSWAAEADVIVAGFGCAGASAAIEAARAGADVLAVDAAGGWGGATAM
SGGEIYLGGGTPVQKACGVEDTPEAMYAFLKLATGPDPAEDKLAAYCEGSLEHFDWLVRC
GVRFEGGLWTEPSWEAPTGYALMYTGGENAHPYAGLVPPAPRGHIVHMEGKKPGERSAGW
MLMDRLAAAARGSGAEVRYDTRTERLVTDGGRIAGIEVTAFGERHFLRARRGVVLAAGGF
AANAPMLAQHAPRLVGNFLVGTDHDDGRAIRMAQAAGAAVRHMEAGQASFPADPALLCRS
LLLDARGHRFINEDTYPGRVGQAALFGQGRQVFLLYDGEIDEAVRASSGHIAEATWVSDD
LAELEGHMGLAPGVLAHTVAVYNANAEQGRDPVCHKSARWLKPLVPPYGVLDLRDTPSGV
FTVGGLHTTPHGEVLDVEGEPIPGLYAAGRTTSGIPSWGYCSGTSLGDATFFGRRAGRAA
ALITH
>C7T2J7|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mesocricetus auratus|TrEMBL
MDLDEFRLLDAFTYLEGLLAFVVLVFLTLVGSPYGRYSAQHPGLQLPARPAWFLQELPSM
AWPLYEYTRPAAARLGSMPNRVLLAMFLIHYVQRTLIFPVLIRGGKPTPMFSFAAAVLFC
TFNGYLQSRYLSQFAVYTEDWVAHPCFLTGFTMWFVGMVINIHSDHILRNLRKPGETGYK
IPRGGLFEYVSAANYFGEIMEWCGFALASRSLQGGVFALFTFSTLFTRAKQHHQWYHEKF
EDYPKSRKILIPFVL
>C7T2J8|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Mesocricetus auratus|TrEMBL
MPTVCHQGPVLAGSATLATIGALTLYLGKPTSYGKHSQSVSSGPLLPARVAWFLQELPSF
VVPVGMLAWQSRSLFGQPGNVLLGLFSAHYFHRTFIYSLLTRGRPFPVMLFLRAIAFCIG
NGFLQAYYLIYCAEYPKEWYTDVRFSVGVFLFILGMGINIHSDYLLRQLRKPGEIIYKIP
RGGLFKYVSGANFLGEITEWMGYALASWSIPAFAFAFSSLCFLGVQAFYHHHRFYLKMFK
DYPKSRRALIPFIF
>P18405|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Homo sapiens|Swiss-Prot
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
>P31213|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Homo sapiens|Swiss-Prot
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
>Q0S4Q9|3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)|EC 1.3.99.5|Rhodococcus jostii (strain RHA1)|TrEMBL
MVDATPIRPRSATTVTEWDYEADVVVAGYGIAGVAASIEAARAGADVLVLERTSGWGGAA
ALAGGFIYLGGGTPLQKACGFDDSPENMKTFMMAALGPGADEEKITDYCEGSVEHYNWLV
DCGVPFKESFWGEPGWEPPFDDGLMYSGGENAAPFNEIATPAPRGHVPQMDGKRTGEKGG
GYMLMKPLVETAEKLGVRAEYDMRVQTLVTDDTGRVVGIVAKQYGKEVAVRARRGVVLAT
GSFAYNDKMIEAHAPRLIGRPGAAIEEHDGRSILMAQALGADLAHMDATEVAFVCDPQLI
VRGILVNGRGQRYVPEDTYSGRIGQMTLFHQDNQAFLIIDEASYEEGAAATTATPFLRVQ
PKWAAETVEELESDMGLPAGALQSTVEVYNKHAAEGSDPLLHKKSEWVKPIGTPVAALDL
RGFTLGFTLGGLRTTVNSEVLHVSGEPIPGLFAAGRCTSGVCAGGYASGTSLGDGSFYGR
RAGISAAKQA