>Q51698|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Brevundimonas diminuta|Swiss-Prot
MKTVLPSVPETVRLSRRGFLVQAGTITCSVAFGSVPAAAGDTAESTPSIAAVSPNVWVRV
HADGIVDIVCPAVELGQGAHTALPRFVAEELDADWDRVRVQQAGASDKVYGNPLAWGTQF
TAASRTTVGYFDVLRVAGAQARFVLVQTAARRWSVPADQLETQKGVVLHRRSRRSATYGE
LVASVQVPESFPHFFARNEATQPADDYFGAAPPSVVAQAAGPASGAIALKHRSTYRLIGK
DAPRKDIPPKVNGQACYGMDVQVPGMLYAMVETGPVAGMAPERVDDGAARQVPGIHHVLS
LPHGVAVVGRDIFAVRAARARLLVNWKANPDKQSYDSGQVLDEFSDLCRNGIERNAVQAW
KQGELSSIDAVFARPDVRIESFEMQSDLVYQAPMEPQSAVIQPHADGSAEAWVGTQWPTV
EQGFAAGILGIAPDKLTMHLPLVGGGFGRRLEPGALVDAAHIVRAIGKTVKVIWSREDDL
KRNPFRQALACRVEAAVLEKDQRILALRHTVAADSWLARLFPQYFNAYQQTDPGNWIGGM
VAYDVPLQRIDALTPRRSVDVCYMRGIGVAQVKFAQESLVDQIARRLNADPVDFRLAHLN
TSPRGAAVVRTVAEMSDWKRRSADAGGGMALGLAYTPYSNAHVALVSEVHFNRSENTLSV
SRVWCAVDVGMVAQPDIVKAQMEGGIIQGLSVALMERVQVAKGVLQHSNFHDYPMLRMSQ
VPQIHVRLVETDQAMAGVAELGLLQIGPAINNAFARITGQHLRSLPMRPALAQMKRSGPT
A
>Q51697|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Brevundimonas diminuta|Swiss-Prot
MIEFILNGQPVRVTEVPEDAPLLWVVREHLKLSGTKFGCGLGLCGACTVHINGEAARSCI
TPLSVVARQSVTTIEGLDPQHAHPLQRAWIAEQVPQCGYCQSGQIMQAAALLKKVPKPSD
AQIVEAMDGNLCRCGTYQRIKIAIHRAAKEAA
>A0A5E6MXS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQQAYEVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAIETDEVGKRVVAAWVERQVAQCGYCQSGQVMAATALLKHTPAPSKA
QIDAAMINLCRCGTYNAIHAAVDDLAKQGSV
>A0A2U3Q652|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium vignae|TrEMBL
MDWANQGTAMANLTINGKTLTLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHID
GVAMRSCGLSVSEAEGKKITTIEGLASGDSLHKVQEAWIAQDVPQCGYCQSGMIMAVAAL
LNEKPKPTDADIDEAITNICRCGTFQQVREAIHTIASA
>A0A2X4ULH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia plymuthica|TrEMBL
MITLTVNDQPLTFEGDTHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAVGKKITTIEAIGETPAGKAVQEAWVNLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMGGNVCRCATYVRIRAAIHQAAKALD
>A0A1Y1ITE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Comamonas testosteroni|TrEMBL
MTRSPGALNSITARRIPPIQCLLTFEALARLRSVTLTAEELCVTPSAVSHRVKQLEQILG
ARLFGRTDFSLTTDGSSYLAHVREGLGALQRFPGASASPGRRRLKLAVTPTFARVILIPR
LRQFTEAYPEIDIALQVSIPLLDVIGEDADLMVRFGAGHYADVEHIELARDTVTPLASPS
FIREHGPFERPDDLEGMPLLRSPLEPWRTWFAATGLDMAEPNEGSQFNDIGLMCDAASAS
MGIALVRHKLGAPWLENGTLVRLFDVDAPSPHAHYLCWKTGIMDRWECAAFAEWLRKAMG
>A0A0D6I2C2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MSDALALTVNGQSLRLDVAPDTPLLYVLRNDLQLNGPKFGCGLGECGACTVLMDGVATRS
CITPVEAAVGRRVVTLEGLGDAAHPHPLQQAFIDEQAAQCGYCINGMVMTAKALLDRNPN
PSDGEIRQELAYNLCRCGTHVEILKAVRRAAESLKEHQEEHPA
>A0A3S0IYN4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MITLNLNGQDHQLDVTEDMPLLWAIRDVVGYTGTKFGCGMGLCGSCTIHIDGQATRSCIT
PVSLAQGRKVTTIDHLHTDKIGEVVQQAWLDIGVAQCGYCQGGQIMSATALLKSNPAPSD
EQIEAAMAGNICRCGTYNRIKTAIHNASAKLQEAKA
>A0A135IJY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter inhibens|TrEMBL
MSTTLRINGTPHEVDLPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGVGTPDTMAAVQKAWVANQVAQCGYCQSGQIMQAASLLAENPSPSD
AEIDEAMQGNLCRCGTYPRIRAAIHDAASMMKEA
>A0A375FP53|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus oxalaticus|TrEMBL
MPDQQLSVNGKRVDIRSDGCTPLLWVLRCELKLTGTKFGCGVGVCGACAVHVDGKMLLSC
QHQASEMAGKRIVTIEGLDGPEASALRAAWLKHEVVQCGYCQSAQLMAASALLRRTRNPK
ETEIVDQMSCVLCRCGTYTRIRRAIAAAVEMLRG
>A0A0F7HCU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia fonticola|TrEMBL
MEIKVNGRLVALSNIPPETPLLYVLRNDLQLNGPKYGCGLGECGACTVLIDGVAARSCST
PLSAAQGKAITTLEGLSQEGHLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFERDPEASE
QQIKNELAFNLCRCGTHLEILAAAKQAKRLLAERGAQ
>A0A7K3VA22|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium leguminosarum|TrEMBL
MTAFTINGRAVDVAAEPDTPLLWVIREHLKLTGTKFGCGVAQCGACTVHVDGVPTRSCVT
MLQDVSGRAVVTIEGLSPDSDHPLQRAWIAEQVPQCGYCQSGQIMQAAALLQSTPKPTRE
QIIEHMDGNICRCGTYGRIISAIERAAQEA
>A0A069BBX3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia pseudomallei|TrEMBL
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
ADIDAAMNGNICRCATYTRIRAAIHEAAATLKA
>A0A1V0Q2H9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MRYTLNLNGKDTAVEADDPDMPLVFVLRDLLGLRGTKYTCLEGACGACTVHIYGVAVRAC
QIPVSDCEGAAIVTIEGLSTAGDHPVQQAWLEERVPQCGWCQPGQIMQAAALIAEDPAPS
EEDIATGMSGNLCRCGTAPRILKAVARAAEITRRDAQ
>A0A853SJA9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MAGEKNTSRRRFLLRGLGLGVAGVGALVLGWGVLPPRQRLHGSVPLPLQDGAVALNGWLA
IGTDGTVTLAMPRSEMGQGVHTALPMLVAEELDVPLSSVKLIQAPMDKIFGNVAMLQDGL
PFHPDDQGRVKALAQWTVAKAARELGVIVTGGSSSVKDGWGPMREAGASARAMLVGAAAA
LWQVPAAQCRTENGAVLHPDGRRASYASLAQRAAAIDPGTPVLKLPRDFKLIGQPAPRRD
TPSKVNGSARFGIDARPPGMLYAALHLPPRLGDILSAFDAAPVLAMPGVKKVLDLTPHLA
QRSVSCAAVVADTWWRARQAAAALPTQWKAGPQANLSSAGVYAEFARLLDSEAGYAYHAS
GQVESKAVQGMRQVSAEYRAPFLAHAAMEPVNCTAQVKDGKVMLWVSTQAPGIAVDVAAK
VAGVAAKDVVIEVLLLGGGFGRRLEVDMIAQAVAIALQCGGAPVQLVWTREQDTQHDMYR
PAALARFAARLDEHGRIASWDNKSVSGSITHQFLQRNFGLPGAGPDKTTAEGEFDMPYEI
ASQRIAHVIADSPVPIGYWRSVGHSHNAFFKESFIDELAHAAGQDGIAFRRAMLVRHPRH
LAVLDAAVAKAGMPPPGHAHGVALHQSFGSIVAQVAQVSVENGEIRVQRVVCAIDCGIAV
NPNIIAQQMESAVLFGLSAALGGEITFKEGKVEQANFHDYPVLRMGQTPEVETVIIASAE
HPEGVGEPGTPPIAPAVANAVFSLTGKRLRSLPLRLG
>A0A031GTA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MAAHSSPSRRRFLLGGLGLGVAGVGALVLGWGVLPPRQRLHGSAPLPLQDGAVALNGWLA
IGTDGTVTLAMPRSEMGQGVHTALPMLVAEELDVPLASVKLIQAPNDKIFGNVAMLKDSL
PFHPDDQGRLKALAQWTVAKAARELGVIVTGGSSSVKDGWGPMREAGASARAMLVGAAAA
LWQVPAAQCRTQDGDVLHPDGRRASYASLAQRAAVIDPGTPVLKSPKDFKLIGQPAPRRD
TPSKVNGSARFGIDARPPGMLYAALHLPPRLGDSLSAFDAAPILAMPGVKKVLDLTPQLA
QRSVSCAAVVADTWWRAKQAAAALPTQWKAGPQANLSSADVYAEFARLLDSEAGYAYHAS
GEVESKAVQGMRQVSAEYRAPFLAHAAMEPVNCTAQVKNGKVMLWASTQAPGIAIDVAAK
VASVDAKDVSIEVLLLGGGFGRRLEVDMVAQAVAIALQCDGAPVQLVWTREQDTKHDMYR
PAALARFAARLDEHGRIASWDNKSVSGSITHQYLQRNFGLPGAGPDKTTAEGEFDMPYEI
ANQRIAHVIADSAVPVGYWRSVGHSHNAFFKESFIDELAHAAGQDGIAFRRAMLVRHPRH
LAVLDAAVARAGSPPPGHAHGVALHQSFGSIVAQVAQVSVENGEIRVQRVVCAIDCGIAV
NPNIIAQQMESAVLFGLSAALGGEITFKEGRVEQGNFHDYPVLRMGQTPEVETIIIASAE
HPEGVGEPGTPPIAPAVANAVFSLTGKRLRSLPLRLA
>A0A841EVI6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arcicella rosea|TrEMBL
MENTNTQNRRSFLKSSALAGGGLMLSFSWFANAQAADKMVAMNLPDQWNELNGYIKITPD
NVIKIICPNPEFGQNVMTSLPMMVAEELEVDWKNVVVEMGTHDSVKLGTQFTGGSNSVRM
YWKPLRNAGASARQMLIEAAAQTWGVPASEITTKAGVLLHSSGKSAKYGEMANKAATIPV
PKEVKLKAPKDFSIVRNSQKNTEGQKIVTGKPLFGIDTHVEGMLIAMIQHPPAFGMKLKS
FDASQALKMPGIKDIFSFKLYDDGFVQAGFDTRTFNEMIAIVGKSTWEVMNARKKIKVQW
EAAGEIKETMMGRGGKREVTIPSRLETTSSQMELMAEYANGRHSAKPAQQLRKDGDPETA
FKNAAQIIERTYNAPFLAHNTMEPMNFFAHVSEDKALVAGPLQAPGLIEPTLTKILNLPA
DKIEIQMTRMGGGFGRRAYGQYAFEAARISQRMKAPIKLIYSREDDMTYGIYRPMYTATY
RAALDANKNLIAFHVKGGGIPENPIHANRFPAGAVDNYLAEGWEIPSNITIGAFRAPRSN
FNAAAEQSFLDEVAEAMGKDPIAFRLDLLKRAKENPVGKNNEYDADRYAGVLELLREKSG
WGKPENSGKKRGVAAYFCHNSYAGHVVDMVIRDGQPYVEKVTSAIDCGVVVNPDAAINMV
QGAVVDGIGNSFYGALTHKDGAAEQSNFHNYRIIRHNEAPKIIDVHFIQNDIDPTGLGEP
PFPPVFGAVANALYKSTGKRYYNQPFTVEGTKL
>A0A7Y9JQH1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides marinisabuli|TrEMBL
MPKQTFILNGKPVTVNVKDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVRVGDLGRDDEVTTIEGLPDTVGQDLHPMQEAWIDRDVPQCGYCQPGQIMAAVALVKKV
RREGREIRDADLDTIRNICRCGTYTRIREAVVQGARGMA
>A0A0J5QG61|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Puniceibacterium sp. IMCC21224|TrEMBL
MTRELRLNGQTVTVDAEDGTPLLWVIRDELKMTGTKFGCGVAACGACTVHVDGAPTRSCQ
TYIEDVEGAEITTIEAMSADRIGAAVQQAWTELDVVQCGYCQSGQIMSAVGLLSENGKPS
AAEIDDYMWGNACRCATYQRIRAGVQRAAEILEG
>A0A8F7WTM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylovirgula sp. HY1|TrEMBL
MLVNSLIQRLAQPELSRRGFLIGATAVGSSLVVGYAHAAEGPAGNAAINPFDGYVKIDAD
NHTTIYSAHMDMGQGIYFCDATLVQDELDADWATLTVDGGFGNDRLYGNIAWGGTIQGTG
GSTGTFSSWERYRKAGAMARTMLIAAAAAAWKVPAHEIVATKGVLSHASGKSASYGAMAA
AAAHMPVPQSVVLKTRKDWLYIGDAALPRYDSARKAEGRQNFTIDVHLPKMLTAVMIHPP
RFGATLKSFDASKAKKVKGVVDVVAIPRGIAVVATGMWEALQGRAQVTAEWDESHIEGRS
SPDILAEYRAAADRGGEAVAKNIGDVAAALAAPGGRIIEARYEFPYLAHAALEPLNAVAR
MNENGTLEVWGGHQMPDIYQAAAAKVAGIPVEKVILHVMKTGGGFGRRAVTDADIIVEAV
GVAKAIGWKAPVKVQWAREDDMRGGRYRPAFVHKLKAVFDNQGALVGLHDTLVGQSIMKG
TPFAAAYVKNGVDATSVEGMANQPYAIPNFRVDLTTPESKVPVLWWRSVGSSHTAYALEC
FMDELAEAAGKDPLAFRLALLQDKPRHVAVLKLAAEKAGWGKPLPAGHAHGIALAESFQT
YVAQVVEVSMQGKNVKVHRVTCAVDCGIAVNPDQVKAQMQGGIGFGLGAILKSQITFDHG
KVVQGNFDTYQVLALNEMPQVEVHIVPSDEHPTGVGEPGVPPIGPAVANAVYQLTKTRIR
SLPFVKA
>B9BJE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD2|TrEMBL
MSHSASAPRPLAFRVNGVPHRFDAAAPDTPLLLVLRNDCALNGPKYGCGLGQCGACTVLI
DGQPARACVLPAAAASGRDVTTLEGLGSRDALHPVQRAFIDEQAAQCGYCLNGMIMSTKA
LLDRNPSPDDTAIREALRFNLCRCGTHLEIVRAVHRAARYLRGDDAA
>A0A839EQR2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium myrsinacearum|TrEMBL
MIALNINGEDRTVDVPEDMPLLWVLRDVIGLTGTKFGCGIAQCGACTVQLDGRPVRSCVL
PVASVGTRSITTIEAVGATPAGKKIQDAWLDLEVIQCGYCQSGQIMSASALLNRNPDPSD
RDIDTAMSGNICRCGTYPRIRAAIKQAAKA
>A0A3G7HEJ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MSKFKSIAGWGLTALSLAVTAGVFISWQPAIAPLDNHDIQYFSHAQVARGEQLAAVGDCA
VCHTAPGGARNAGGLAMRIPFGTLYSTNITPDPETGIGSWSYPAFERAMRHGIDRNGRYL
YPAFPYTAFTKTRDDDLKALYAYLMSQPPVRHQPPPTDLHFPFNIRPGILAWNWLYLRPG
AMADDPGRSAQWNRGAYLSEGLGHCSACHSPRDPLFGERGGKRHLSGGIAEDWSAHALAG
GKAPLAWTEQDLLDFLRHGYSQRHGVAAGPMAPVIHEGLAQLPEADLQAIAHYLSSLQPA
SAPQASAATLNHQAEQRTEPLGAPGARLFSGACMACHAQEKGPTLTGVRPSLALNSNLYA
DSPDNAIRVILEGIAQPANPELGYMPAFRHSLDDQQIADLLLFLRQDLAGQAPWKDVKQR
VSHIRASLPPG
>A0A2H5VRY8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR09|TrEMBL
MARFTLDVNGAKRTVEVAADTPLLWVLRDHLGLVGTKYGCGVGLCGSCTVLVDGEAERSC
SVAVSQVVGKKILTIEGLGGQHPVQEAFVAEDVPQCGYCQSGQVMQAVALLSKNPHPTSE
QVAAVMGDILCRCGTYDRIAKAVARVARR
>A0A0D1CQV2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia aquimarina|TrEMBL
MTAFTLNGEEVSVDADPATPLLWVIRERMGLTGTKYGCGVGACGACTVHLDGQPVPSCAL
PLEAAEGAQITTIEGLSKTGDHPVQQAWIEVDVPQCGYCQSGQIMATAAMIRDVPDPTDA
DIDAYLAGNLCRCGVYNRIRVAAKRAAEIARG
>A0A2P9GWS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderiales bacterium|TrEMBL
MVRNMTTLNINGKSVEVDADPSTPVLWALRDTLGMTGTKFGCGVAACGACTVHINGQPTR
SCVTPIAAAVGQKITTIEGISNGRVGKAVQAAWIAHDVAQCGYCQSGQIMTATALLEGNK
KPSDSDIDAAMAGNICRCGTYQRIRAAIHSAAKTLA
>A0A5C6F8I2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubripirellula tenax|TrEMBL
MNQSTKTESQLNRRSFIAGVTAGSLVLMAKLNGQEVTVADASKVNANDFAPDLFVSIAPD
GLVSILSHRSEMGTGIRTSLPRIVADELEADWDRVKIVQAIGDKRLGDQNTDGSNSVRFF
YDRMRVAGATARTMLERAAAQAWSVDAANCKANNHRVDEIDGNRSIGFGDLVAIARTLDV
PSADELTMKTPDQWRYIGKDAPITDMDAILTGKAVFGIDARMDNQLFAVIARPPVVGGQV
KSFDAADTRKMAGVIDVIEIPKFQGAPLFQPLGGVAVCATSTWAAWQGRDSLTIDWDHGP
NQDYNTDDYAKTLSQSANQPGKAVREHGDALKEIQQSPNVFNADYSVPHLAHAPMETPCA
VANVKTDGDKVIACEITAATQNPQAVQQAVGLAMGVPHDSVIVNVTLLGSGFGRKSKPDY
CVEAAMLSRHVGRPVHVTWTREDDIQHDYLHAISHVHVEAAVDDQGNPTAWLSRAAYPSI
GSTFNADAVEPADFEYEMGLTDLPFDIPNLRVEVGQANAHTRIGWLRSVCHIQQVFAMSS
FADELAQHAKRDPYEYLLGLLGEDRHIDLEAAGLANRGASGEDFPYDIGRLKEVVRRVAK
QSDWQRHKDLPRGRGLGIACCRSFLGYTGHVVEVDITQDGKLSIPKVWVSMDAGLIVSPD
RVRAQIEGAAIMATSQARYGKITFKQGRIQQSNYDTFRVATMRNAPREINIDLVDSMAPP
AGVGETTVASFAPALCNAVFAATGKRIRNLPLADHDLSWA
>A0A7W5DBQ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. Sphag1AA|TrEMBL
MNSNATLDTQSTAALSRRGFLQTTAFVGGGLMLGVVLPGFVGDAQAAGTLHTPNAWVHIA
DDNTITLLSARSEMGQGVYTSMPMLIAEELNVDIHKIKVAIAPPNTKLYGNALLGGPQLT
GGSTSVRDGWEKLRIAGAQVREMLITAAADKWKVDRSTITAKDGVLHGPGGKKATYGQLA
AAASQLPVPEKVALKDPKDFTIIGKRTTRLDTPAKTNGTAVFGIDVKLPGMVYASLEQCP
VIGGTVKSLDATKAKAMPGVIDVVQIPDGVAIVADSWWHAKKAREGLTIVWDEGPGATLN
DKAMLAGIRAGSPSDTVLPLKAVGDADAVIGKSAKVVKAEYTMPLLSHSPLEPMNFTAHV
HDDKVDLIGPTQWQDAAQATVAKVLGVKPENVTLQTTFLGGGFGRRIDIDYIIQAAQISK
AVNKPVKLLWTREDDMTHDFYRPQSVHRLTASLGDDGKPTAMTFRIMSQSVTARIFQLPP
DVQDPLMTEAAMAPYEIPATKHDVVKHDAGMRVGYWRSVSHALNAFANESFIDELAAAAG
QDPYAYRMSLLANKPRFANVMKMAADKAGWGTPAPAGRFRGMALMEGYDTYMAQVAEISM
KDGVPVVHKVTVVADLGRMVNPDTVEAQIQSSVIFGMTAALYGEITIENGRVQQTNFHQY
QMVRMNEAPVIDITLVPSTEKPGGIGEPATALIGPAIANAMFAATGKRVRSMPLTRDNLQ
NA
>A0A7W9HGK2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharothrix ecbatanensis|TrEMBL
MGRYRLHVNGERREVDLPAETPLLWALREQLGLLGPKYGCGVGACGACTSLVDGQAARPC
VTTVAEAQGRRVTTIEGLSEDGDHPVQQAWLELDVAQCGYCQPGQIMSTVALLAVDPDPD
DAAIDAALRDNVCRCGTYTRVRAAVKRAAQLKRGRQ
>A0A6S7DBB8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter piechaudii|TrEMBL
MSTLNINGQDHEVDVDPTTPILWALRDTLEMTGTKFGCGAALCGACTVHLDGNAIRSCVT
PVAAAEGLRITTIEAATDGSDPVGAHVHAAWVRHDVAQCGYCQSGQIMSAIAFLKSIPAG
KQPSAEEIDNAMAGNICRCGTYARIRAAVADAARALA
>Q3JGA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia pseudomallei (strain 1710b)|TrEMBL
MQDCSIFLQDCVNATAVRPSHCRLSPGAKSGHSPTEIVHVYLVCAERQEPHAGRRSRDAA
PLGDPRGRGPARHEVRLRRRAVRRVHRASRRPGGALVRAAARGRRRQARDDHRRTREPAR
EGRPGCVGQAAGAAVRLLPVRPDHVGDRAPRTEPGADRRRHRRRDERQHLPLRDLHPHPR
RDSRSGRHPEGLTMTTDLDLPDAVRASRRTFLKAAGAAAAVGLTIGFEWLDASRPALGAN
APAAPAGDAAGAFAPNAFLRVAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWRDVR
VESAPADASRYANLQFGKLQGTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWNVPAAE
LTTGDGVVRHAASRREATYGSLATAAAALPVPEQVALKSPSDFRLIGKPVPRVDARAKSD
GTAQFTIDVAMPGMLVALLQRPPVFGGKVKSFDASAAKAVPGVVSVVQVERGVAVVAKGF
WAAKQGRDALKVEWDESGAEKRSSDAIMREYRQLAERPGASARRDGDAEHALAGAAKRLR
ASYEFPYLAHAPMEPLDAVVKLSADRCEIWAGDQFQTIDQGNAARVAGLDPSQVQIHTLY
AGGSFGRRANAWSDYVVEAVSIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAAL
SKDGKLVGWRHRIVGQSILAGTPFEAVMVKNGIDQTSVEGAANLPYAIPNVSVELTTTRS
AVPVLWWRVVGSSHTAYAVEAFIDEAAHAAGKDPYLFRRDLLAHAPRLKGVLELAAEKAG
WDPGKPLPKGRGRGIAVAEAFKSYVAQVAEVSVDEHGAVKVERVVCALDCGTAINPDVIA
AQMEGGIGFGLGAVLHGAITLKDGKVEQNNFDGYRVLRIAEMPKVEVYIVPSGEAPTGVG
EPGVAPIGPAVANAIFAATGKRHYALPFPAAGEATA
>A0A5S9N921|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Starkeya sp. HF14-78462|TrEMBL
MIEFTINGRAVSVDVEPDTPLLWVIRDEVALTGTKYGCGIGLCGACTVHVGGRATRSCIT
PVSDVAGAEITTIEGLDPKGEHPVQQAWRHLRVPQCGYCQSGQIMQAAAFLKDIPNPTDD
DIDAVMTGNLCRCMTYNRIRAAVREAAATLRGEATNG
>A0A7W8XWS1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium paranaense|TrEMBL
MKVDFTVNGSARSIDVDPATPLLWVIRDYLKLKGTKFGCGVGECGACTVHLNGEAVRSCI
TTVDSVAGGSVTSIEGLSPNHSHPVQQAWIEHAVPQCGYCQSGMIMAVSDILAKNPSPTD
EDIDKELTNICRCGTYPRVRAAIHAAAAMMKGAAQ
>A0A7Z0DKZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides panzhihuensis|TrEMBL
MPSHTFQLNGESVTVDVEDDVRILWVLRDVLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVRVADIGADDEITTIEGLADTAPGEGLHPMQEAWLEHDVAQCGYCQPGQIMAAVALVNK
VREEGRAINEADLDTIRNVCRCGTYSRIREAIKTGQDAMARGL
>A0A7G6UYB0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MGLGIALHGEITFKDGRPEQSNFNGFQVLRMNEAPREIRVHLVAPDDYATPLGGVGEPGL
PPVAPALTNAIFAATGTRIRSLPVADQLAKPQAG
>E8UXU9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)|TrEMBL
MTQWLAIFAVAPLTSAFATPSIAPRRKLTHEHETHLRANEDRWGDFPPHLPYNLCCGRGA
LVIGLTLRGRFHHPSSEVSKDPFNAWIRIHPDGQIQLVLNKSEMGQGVFTALPMILAEEA
EIDFSRITVIQADDADGTGGSGSVAGGYKPLRQAGAQVREVMIAAAARRWAVPTAQCRAR
NSQIIDTSSGRTLSYAALVKEARRLPLPDAKTVPLKDPKDFSLLGRSVRHLDIPHKVKGA
ARFGLDVRLPGMVYAVVAQCPYFRGELVSYDAAKAKAIPGVLEVFDIPTDLQSANKNTRE
VAVVATNTWAAIQGRNALATEWKSGQYHDESTETLTTQLRAALDAPEYWNSTNTELNPDI
VPAAKRLEAIYEFPFLAHVTMEPMNITVSLEGGRCEIWSPTQAGEGTRETAAKLLGIDKK
NVTVHVTFMGGGFGRRFGAPFDHQAIHIARSVRRPVQLIWTREDDFTHDRYRPAGMHRLR
AGIDQEGTLVSWTDRLVDTTIIGQGDPKQAQLFELGGALDQPYPAQHFRISYVPIDSGAT
RGAWRGVEISFNVFAVESFIDELAHLAGQDPCLYRRRLFENTAAQTRTPRSNFDGALADP
KRMIEMLDLTAEKAAWGKPLGVHRGRGISCFFSKTTYLAQVTEVTVKKGNISVDRVVTVV
DPGTVINMNGIRAQIEGAILMGLSATLKERITVKDGMIQQQNFNSYDLLRMPDTPHLETH
LVEGGRLPGGIGEPPLALIAPSVGNAIFAATGKRLRKLPLQLDEVSS
>A0A1B9VGI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassospira sp. KO164|TrEMBL
MQYQLKINGESRTVEAEPGTPLLWVLRDGLELTGTKFGCGVAYCGACTVHIDGYPTRSCQ
TFIEDAVDSEITTIEGATDKIAQAVQAAWQEKDVVQCGWCQSGQIMSAIGLLTENPKPTD
DEIKEYMYGNACRCVTYVRINEAIKLASEKLEA
>A0A853B5G7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis endophytica|TrEMBL
MAPQRRSPAPGDGAPALERRRFLGYLLAAPTLAVAARLGGDLASPAPADAAIPGLPGPAD
ILDLGDALSLAAAPTSGLIAIQVNRDDTVSFAVPRAEVGQGITTTVAMLIAEEMDLPLSK
VGVNLADARPELVFNQLTGGSNSVRSLYTPVRTAAAIARSRLLSTAAALWKTDVSALSVR
DGVIRSRSGATATFGSLAGAAASARTEETGATLKRTSEFRIIGKPTGRIDALDAVTGRKQ
FTMDLQVPDAKPTMICRPPTINGTVRSVRNSAEVKAMPGVTDVVTVSSGVAVRAETFGQC
IDAVRALKVNWGPGTVDGESDATVEAKLRAAALPLAVPPVLTQSIDAEFVFAFASNSALE
TNCAIADVRADRAEIWSGLKSPIVAQEQIATMLGLPIPAVKVHVVTGGGSFGRKLFGDAA
LEAAEVSKKIGKPVKLMWHRADDSRHGRTHPACISRVRVNHALGNVVSYEQRHTSVTTDF
GHGLGEILTAVAAKLPVGDVGFSQTVFLLSTSMPYDFGVTTQLLNEVPLKFHTASMRNVY
SPNVVCARELIVDQLAAKMGQDPLAFRRGFLKDDRMRAVLDKVAEVGNWGRKMPAGTAQG
IALHHEYKSVSAVLMEIDCRPETVNRKIRDAVAGPRITKAVAVVDAGLPINPAGLEAQTI
GCVNDGIAMALTSSLHVDKGLPLEASWDNYFYTRQWNTPPEMEVVVMPATTGEPGGAGEL
AVASSFAAAACAYGRAMGKMPTRFPINHGTLSFEPKPKVPPVPESPVDGLSYTY
>A0A0M2WS73|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. KBS0711|TrEMBL
MITLNINGRDTQVDADPSTPILWALRDNLNMTGTKFGCGAALCGACTVHLDGQPIRSCIT
PISSVGAQKITTIEAMENDQVGKAVQAAWVRHDVPQCGYCQSGQVMSATALLRTNKAPSD
ADIDGAMSGNICRCGTYQRIRAAIKDAAKTLA
>A0A149VU83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ferrovum sp. PN-J185|TrEMBL
MTVSITRRDFFKVIALATGGFAVGLNRSTFADTKTDIFTPNPWVKIEPNGLVTILIDKSE
MGQGVNTSLPMLLAEEMDADWTNIRVEFAPADPIYAHPWFHTQATGGSTSVRAMWMPLRQ
AGAAAREMLRQAAANKWKVSIDSVHISNGIVHSGLHRTNFGGLAHEASLLPAPTKVILKK
PEQFKLIGQSIPRVDNLAKSTGRARFGMDIQLPGMLVAAIIRGPHPGAKVKTFNAEKAKK
INGVHYVLKVNSPTCEGVAVLADNTWIAMQARKSVEVEWDNPVDTALNSADLLDKMKHLI
ATPALAKTAVNKSSASATTHASTIQSTYFAPFLAHAPMEPLNCTAWVQHDQVEVWVGTQA
QGPNQQMISELTGIPTKKVNIYTQYLGGGFGRRFAPDFVMEAVQLSKQILTPVKVVYDRT
DDLTQYYYRPTALCQLQGSIDNNGMISEIKAITATDSIAEGTGFEKALIKEGVDQTSVEG
LHDIPYLIPNFNVKWADLHSGVRTWFWRSVGHSQNSFFSECFIDELAYQAKTDPLEFRLK
HLKHTPKHYAVLKLLQDKSNWSSTLATGHARGVAIVESFGSVVAQMVELSLVDNKPKLHK
VVIAADVGTVVNPDNVKAQLEGAMIFGLSAALYGEVTFQNGHPQVINFNNYPVARMDEVP
PVEVFLIDTQDNPGGVGEPGTPPIAPALCNALYVLTKQRIYQLPVIKV
>A0A6J5D932|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia humisilvae|TrEMBL
MFTVNINGQDQQVDATPEMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGRPARSCVT
PIAAVGQRKVTTIEAIGDTPAGRKVQQAWLDLDVVQCGYCQSGQIMSAAALLAAHPAPTD
ADIDSAMAGNICRCGTYVRIRAAIKHAAQGA
>A0A2Z5SG35|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Geobacter sulfurreducens|TrEMBL
MIVFLVNGKEQRVDVSPDTPLLWVLRDKLGLTGTKYGCGEGLCGACTVHIDGRPERSCIT
PVGDVQGKKVVTIEGIPENHPVKQAWLAQEVSQCGYCQPGQIMSAVALLASKPRPTDADI
DDAMSGNLCRCGTYGRIRRAIHAAGGRRARKGGSRS
>A0A7W7HVN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes digitatis|TrEMBL
MSPPFGRRRLLGYVLAAPILVTAAPLRASARDLTEVLDLNDIMTAAALPTSGLITVEVNQ
DGTVSFALPRAEVGQGITTSTAMLIAEELSVPLRRVRVTLADARPELLFNQLTGASNTTV
STYTPIRVAAAVARQRLLAAAEAELGTPATGLRLDAGVITDDRGRGIDIGTLAVKAASPR
TAPVPVTLRTRESLTVIGRPHNRVDALDAVTGRKRFAMDLDVPGAKPTMVCRAPTINGTV
RSVANLADVRAMPGVTDAVVISTGVAVRAETFGQCIDAIRTLEVTWRPGTAEGESDETVL
RQLAAAELPLGPRPPTPVVEGRFTFHFRGNSALEPNCAIADVRRDRAEIWSSLKSPIVAQ
ETIAARLALPRGRVTVHVTEGGGSFGRKLFFDAALEAAEVSQKIGKPVKLMWHRADDTRQ
GRAHPMATSRVRIAYAGDVVLSYEQRHTSITTDLGHGIGELFTAMAARLPIGGAAFSQIF
FQFSQTSPYAFGSHSRLLNETGRGFNTGSMRNVYSPDATCARELMVDQLAARMNKDPYRF
RRDLLRDDRARAVLAAAATAGEWGRSLPAGVAQGIAFHSEYKAVSACLVEIDCRPATANR
PIRDGVGGPRVTRVVFAVDVGLAVNPRGLEAQMMGCVMDGIALALTSSLHLRDGYFLEAS
WDNHFYTRQWNTPLDLRVIIMPSTSEQPGGAGELGVAASMAAVACAYGRATGTLPTRFPI
NHGTLSFVPKPTVPPVPASPTDGIRHA
>A0A840BWQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chelatococcus caeni|TrEMBL
MTAFTINGRAVDVDTAPDTPLLWVIREHLKLTGTKFGCGIAQCGACTVHVDGAPTRSCVT
WLEDVAGRRVTTIEGLSPDAGHPLQKAWIAEQVPQCGYCQSGQIMQAAALLESNPNPTRE
QIVEHMDGNICRCGTYVRIISAIQRAAREG
>A0A852W0Q8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia antarctica|TrEMBL
MPSHTFTVNGEKVTVDVEDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVGAISESDEITTIEGIAKGEELHPMQQAWIDNDVAQCGYCQPGQIMAAIDLVKRCAA
EGRSIDDDALDEIRNICRCGTYNRIREAIKAGADNM
>A0A6J4UHR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thermomicrobiales bacterium|TrEMBL
CFGGLHLTRESAVAPGKDAGAKDPALYRVVGQSVPRVDLLAKLTGGAAYVHDLKLEGMLH
ARVIRPLVRTVDGVGASLVSVDESSLDGLPGIVAIVRSGDFLGVVAETDAQALAAGQALR
VTWSAPAPLPDFARRFDDFRRSPTVLETVLSTGDPDAAFARATRTVAATYRHPWQAHASI
GPSCAIADVRPDGATVWCASQGVFALREALAPVLGLPEDAVRVVHMEGPGCYGHNGADDV
AADAALLSQAVGRPVRLIWSRQGEFAWEGKGPAMVSEVRAGLDETGTIVAWHYDVWTPTH
STRPGGQPGNLLAGQLKAPPVPFAPLGRGGGTRNALTSYTLPDQRVTAHWVIDPALRPSA
LRSLGGLANTTANESMMDELAALAGADPVAFRLRHLDDPRAIAVIEGAARLAGWRPQHPA
SRTPISTDVRDAALTGRGIAFARYETAYAYVAVVAEVAVSPETGEVRVTRVCVSHDCGLI
VNPDGVRNQVEGNVIQGVGRALFEEVTWDETRVTSLDWDTYRIMGFDDIPEIRIDLIDRP
DQPSWGAGEGAICPVVAAVGNAIADATGVRLRTVPFTPDRVRGALMPRWSGEAG
>A0A085FS58|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. LC238|TrEMBL
MSQLKSAPTSPSRRSFLRTSAVGGAFMLGMSAEGVLAAAANTAASADFTPNAFIRIGRDG
RVTLISKQPEIGQGIKTSLPMVIAEQLEVDWKDVRVVQGDLDPALYGPQGAGGSTSTPNN
YENFHRLGTAARMMLVQAAANTWSVPVSECAAAKGAVVHGQSKRRLAYGALVEAASKLPV
PDAKSVVLKDPSTYKLLGTRIGGVDNAAIVAGRPLFGIDVRLPGMLYAVYAKCPVFGGKP
VKANLDAIKAMPGVKDAFIVEGTSNLNGLRPGVAIVATSTWAALRARRELQVTWDEGEGA
NHSWADFTAQAQAASKKAGAATVRKDGDVPGALGKAAKVVEAAYSYPFISHASMEPQNCT
AWFKEDGALELWAPTQNPGSGQALVTSTFGIPKEKILLHIIRSGGGFGRRLSSDFIVEAT
AIAKRVAAPVKLTWTREDDLQHDHFRPGGFHFLRGGVDAAGKAVAWHNHFVTFANRVERE
GKSVLQPGSGGNLSSDEFPGRWLENCLFEQTMLETRVPMGPWRAPGSCVFSWVLHSFIDE
LAHAGGRDPLEFRLELLGSKDLVPASFERGQPYDVKRMRNVLVEVAQRAGWGKKSFPRGQ
GQGIAFHFSHRGYVAQVAEVTVSREGKLKVDRVMVAADVGSQIVNLSGAENQVEGSVIDG
LSTMMFPELNIEKGRIVQSNFHDYGLLRMPDTPTRIETHFIKTDNPVTGLGEPALPPLAP
AVCNAIFAATGKRVRQLPLSKTDLSWS
>A0A6J4UBT2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thermomicrobiales bacterium|TrEMBL
MSGPDHDTSGQSVASWITIEPDSTVTARSGKVELGTGLRSALRAIVGAELGLPARRVRMV
LGDTALVPDQGVTAGSKSIQTAGMLLQRAAAAARRELVAAAGELLGTAVDDLALRDGAIV
DRKDPARFITLGQLAAVSLDVPVPDLMPGDPLPACGGDMDLGRIELPEMLTGSFRYVHDL
VLAGMLHARVIRPHRRVPEGIGASIATLDTSAAEALPGVLAIVRDGSFLAVVAEREDAAI
AAANAIRVEWTTHPPLPDQADLFDAIRRAPVVESRHTPGDAPPPANALPSGQTLHARYEV
PYQAHGSLGPSCAVADVRDDGATIWSSTQGVFSLRDAIAPLLGLMPGQVRVISTEGSGCY
GHNGAEDVAADAALISQRVGRPVRVQWSRQDEFAWEPKGSAMVSEVSGSLDEAGAIVGWT
YEVWTLTHSNRPGGQPGLLLAASQLAEPIPSPQRRRFGGGDRNAAHPYDLPHSTTTAYWI
EAGPLHQSSLRSLGGFANTTAIESFIDELACAAGADPVAFRLRHLSDPRAREVIERVEAT
AGWCPGPARSGARNGSRDGMLHGQGIAWTRYEGEYAYVAMIADVSVDPGSGAIRVERVTV
AHDCGRIISRDGVANQVEGNIIQGISRTLKEEVTWDADGITSLTFASYPILTFPEVPEID
VVLIDRPGEPPWGAGEPAICPVAAAIGNAVFDATAVRLRRLPFTPQRFRDTREYRQRVKM
TSR
>A0A168K917|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Frankia sp. EI5c|TrEMBL
MPEHTFRVNGEQVTVDVPDDVRLLWVLRDVLGITGPKYGCGINVCKACTSHLNGKAVNPC
AIPVGDLQPADEVTTIEGLPATVGRELHPMQQAWLDHDVAQCGYCQPGQIMAAVALVRRV
AAEGRAITDADLDSLRNICRCGTYFRIREAVRTGAAHM
>A0A482ZHR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MYSCDLRIDLSRLHSNARNSALSWSCDLRIDLSRLHFYRSRPKHVACCDLRIDLSRLHSR
SSLVLVLGSCDLRIDLSRLHLSYTIGKGIDCCDLRIDLSRLHFTDHLIFLRYSCDLRIDL
SRLHFQTPRSLSCCGCDLRIDLSRLHSKLSYNETLLCCDLRIDLSRLHYQRPWSRGGACC
DLRIDLSRLH
>A1TU37|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax citrulli (strain AAC00-1)|TrEMBL
MNLPRPHDLHAPLLDRPDTLLVVRQPVAPPKPAPGQPGSGTDYVQATPEIFVAVLADPGA
EAGWRALAFNGHVDLGTGIRTALAQIVAEELEVPLARLEMVLGHTAASPNQGPTIASASI
QISAVPLRRAAAQAREQLLALAAAQWGVDAGRLQARDGVVYFADGGDARTLHYGQLLQNL
QGQRLHLPLAPPEQPVKLKPASEYRLVGRGAARVDIPAKATGELSFVHDVRVPGMRHGRV
VRPPHPGRDGGDFIGHCLVAVDHASVAHLPGNVQVVTEGDFVGVVADREEQAIAALRALR
VQWRPVPPAPDLRDVAGAIRANPAQRRALVDEGDVDAAFADPRTATVLERSYVWPYQMHA
SIGPSCAVADFQGGRLTVWSGTQNPHMLRTDLDRLLRLGEDRIDIVRLEAAGCYGRNCAD
DVCADAALLSMAVGAPVRVQLTREQEHQWEPKGTGQLMDVRAAIGQGGELLACDFAVRYP
SNDAPLLALLLTGRVPGQPRTLEMGDRTAVPPYRYASRRIACHDMAPLVRSSWLRGVSAL
PNSFAHDCMIDELAQAAGADPVEYRIRHLDDPRAIELIVATARHAGWRRGQPGSRGRPGA
QGLLRGRGVAYARYVHSRFPGFGAAWAAWVVDIEVDPASGRIAVRRIVVGQDTGMMVNPD
GVRHQIHGNVIQTLSRSLLERVAFDERGVASREWGGYPIIGFRDVPPIEVVLMPRQDEPP
MGAGESASVPGPAALANALFDATGRRFYRAPFTPDAVRSALGSA
>A0A2U3PUX5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium vignae|TrEMBL
MARLKTIARRTFLVGSAAIVGGVAFGYYSLRKEPQNPLLKDLKSGQAAITPYVRVDSEGV
TLITPRADKGQGAYSIQAHLIAEELDVDPNKVRIDPGPPDTAYFNSRIMDDSLPFATIDE
GVMARGARGGGEVLSRLLGMQITGGSSTVPDGYHKLRVAGAVARETLKEAAARRSGVPRS
QLKTSDGKVILPDGKSVTYAELAAEAAQIAPITDVALRPEKEWRYIGKSMRRIDIVAKST
GTQRYGIDVRLDGMVYATVRTNPGIGGTIKRYDASNAEKMRGVKMIVPIKDGVGVIADNT
WRAFHAAEAIKIEWNDPPYPADSAGMWKVLEGSFSKDQQDSRLRNDGDVEKALAGASKSI
EAEYRTPYLAHAPLEPMNAVVLYTKQRIDIWTGTQIPVFLRAHAAKLTQLPEEKVYVHAQ
PIGGSFGARLDDTYAQQAVELAMAMEGVPVKMTWSREENMAHDYPRPIQLSRAKGSVRDG
KVESMSIDIAGQSMGASWFSRLQAPVPPGPDTTSVNGIWDQPFSIPNYRVTGYRTKEMVP
VSPWRSVGASGNGFHCASFLDELIYAAGADPMSELIRLCNHEPSKAVLHTLRDISDWKGV
RLDDRRARGVALTLSFGVPMAQVVEISDTAQGIKIEKVFAVCDVGRILDPVNFEAQVQGG
IIWALGHAMNCELTYDNFAPNQTNFHVYEAMRFPQVPKIIIKGLELGPEVRGIGEPPVPP
AAPALANAIFALTGKRVRELPLNKSVKFA
>S9QPC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger mucosus DSM 16094|TrEMBL
MASIGKIARRTFLVGAAAVAGGVAVGAWYVSRPAPNPLRPEGDETALNPFVIIDGEGVTL
VAPRAEMGQGTQTTWAALLAEEMDLAWEDVRVIHGPPAKAYYNSAMMAESLPGPAGYARS
ALQHKLGEMAGVIGKVMEMQVTGGSTAMKDGYERMRATGAAAREMLKAAAAARLDLDAGV
LTTEAGAVVAPDGTRLPYTELAAEAAGFEPRDVLLREPSEWKLLGRALPRLDMVAKCTGT
ETYSIDTRPEGLRYAAVRMSPRRGAMRGFDAEEAEGMPGVEKIVDLGDGVAVIATNTWLA
QQAVNAIEVDWGPAAYPETTGAIFDEIEAAFDLDPDSTLRDTGDAETLPEGAQEVTAEYR
LPFLAHATMEPLNATAWITAGGLEVWSGNQIPTFVRDACAEAAGVSADSVTLHTTPMGGG
FGRRGELDFSVLAVRVARALPNVPVMTTWSREEDMTQDFYRPGAIGRMRGAVQDGTAVLL
DASVAGPSTARQALNRWTGFAPGGPDKVHVEGLWNQPYAIPSYRARGYIAPDLQVPVGFW
RSVGNSYNGFIFESFLDEMANAAGADPLDFRVQLAEPEWDPAARVLEAVREMSGWPDKPE
GTGRGVAMCYSFGTPVACVIEVADEEGEIRIARAWMAADPGVALDPGIIEQQLAGGLVYG
LSAAMTGEITFADGAVEQRNFPDYDALRMGQMPRVEVRILERQTHISGIGEPGTPPAAPA
LANAIFDLTGERHRELPLSRAVRFAT
>A0A852RDC1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides kongjuensis|TrEMBL
MSHDQTTDQGQRRQRAGRLSRRSFVGYVMGGTGLVVAADLALGAAPAQAAGLPIPSVPQV
PELYDLNDFLTHCTLPTSGLIAIHVDEQGDAHFALPRMEVGQGITTSTAMIIAEELDLPV
ERVHVTLAPARKELLFNQLTGGSNTTISTYTPIRVAAAVARKALLDAAAIELGALVTTLR
VKGGVIFDLLGNSLSYGDAAALAAPATTQRVEVELKTLSEHKVVGTPQRRLDARDAVTGR
KKFAMDLTDADVPGALPTMVCRAPDLNGTPVAIRNRAAVEAMPGVTHVAIIPTGVAVRAR
TFGQCIDAVRALDVEWKGGTVAGKSSADILTELRAAQLPLAVPKLGATTVEGDFVFHFRS
GSALEPNCAIADVRDGTATIWGGLKSPIDAQSKVAKALGLPQAKVSVNVVQGGGSFGRKL
FSDAAIEAAHASKAFGAPVKLMWHRADEPRQGRVHPMATSRVRATVLLGSVISFEQRHTS
VSTDFTHGLGERLTAEVAALPTGLANLGFSETIFLLSQELPYNFGVVTQLLNESNRDFDR
FNTSSVRNIYSPDVRTANELIVDQLAARLKLDPVAFRLKYLKSGIVKNVLRKAAELGEWG
KQMPAGTAQGIAIHKEYKGATAVVVEIDCRPETVGRKVRDAVTGPRVTRATMVVDCGLVI
NPLGVQAQMMGGFSDGLAQALSYGNHLVDGHFLEASWDNSAYTRQWNTPFDFHCEVLDSD
REEPGGIGEAGVAASMAAVACAYARATGTMPTEFPINFRAPLHFEPKPFVPPVPASPTNG
LDFVS
>A0A0F7KX08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Croceibacterium atlanticum|TrEMBL
MSDLMEKAASPQLSRRTLLKAGALAGGGLTLTASIPMVARAAAGAEPAEAMLNAFITIAP
DNTITIVGKNPEIGQGIKTSLPMLVAEELDADWDQVRIVQADADMAKYGPQMAGGSFSTP
MNWMPMRQVGAAGRQMLLEAASRRWGVDSAKLQTRLGTVVDPASGRSLTYGELASEAAKV
AVPDIAKVPLKDPQDFKIIGRAIGGIDSPRIVRGEPIFGVDTQLPGLVYAAYERSPVFGA
KLVSARLDAVKAQPGVIDAFVVEGNGNAEQLVDGVAIIAKNWWIANKAREKLEIEWDNGE
WASHSSAGYDKKARELMAAGKPEEVFSSEGDVDAAFASAAKILEAEYSYPFLAHVPMEPQ
NCTALCKDDGSIEMWAPSQTPQGGQQGVAQMLGLKPEQVTVHVTRMGGGFGRRLTNDYMH
QSAAIARKMPGTPVQLIWSREDDVRSDFYRPAGWHRLRASLDENGKLTGFDDHFITFDLG
DGAYNPAAMAPDIFPAKFVPNLRYAQSKLKSAVPMGALRAPSSNALSFVTQSFLDEVAQE
QGSDLPNLMLELLSTRGPFPDTQGFVGMQPGFKPARAKAVIEKSMQMGAWGTPSAEGRAK
GFGFYFSHMGYFAEVVEASISDRGQITVHNVWAAGDVGSHIINPFGALNQVEGAIIDGIG
QAMSLAVEIEGGATVQSNFHDYPVPRMPVTPNIEVEFIKTDYSPTGLGEPALPPVIPALV
NALAALTGKRVRSLPIDGKALV
>A0A7W7E671|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MIEIVVNDTRHSLDNVPEDMPLLWVLRDRLKLTGTKFGCGGGFCGACTVHLEGEAVRSCL
LPIAAVAGKHITTIEGLSKDGTHPLQLAWVAEDVPQCGYCQSGQLMQAASFLKGKPTVND
ATIATAMSGNICRCGTYSRIRKAIKRAASGDAALAAVAPPCAAACAAPSASANEEA
>A0A852RPL4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides kongjuensis|TrEMBL
MPKHTFQLNGETVTVDVEDDVRILWVLRDVLGVTGPKYGCGINVCKACTSHINGKAFNPC
AVPVGAIGPDDEITTIEGLADTVPGDGLHPMQDAWLDHDVAQCGYCQPGQIMAAVALVDR
VRAENRAITEDDLDSIRNVCRCGTYPRIREAIRAGAERM
>K6XT68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aliiglaciecola lipolytica E3|TrEMBL
MNHKIENVSRRHFLKVSGIGAGSFVLGSALPIAKPVWAEQSKLAVELNLFVSINTDNSVN
IVCHRSEMGQGVRTSIPQVVADELCAKWDLVSVVQGLANAEYGSQNTDGSRSIRRFYTTL
RQMGAAARAMLEQAAADLWKVDVSSVYADESYIHHKNSNRKVSFGYIAEAASKLTPPTNE
ELTFKSKKDFKLIGKPITGIDLPNIVTGNADFGQDIKMDSMLYASIERSKVLGAKVKSFN
ADAAKSVNGVVATFKMPDQPTPVVFHPMNGVAVIATNTWSAMQGRKVLDIEWELGANAEH
NSADYVTELKSRIVNKGKEIRAEGDAYADLEKAKQTHSATYSIPYLIHAPMEPPAATAVF
KDGKCEIWACTQTPQSTQANVARALGIEADDVIVNVTLLGGGFGRKSKPDFSVEAAILAK
EMQRPVKVVWSREDDIQQGFYHAVSVQHFAAGMDENNLVSSWLQRTAFPSISWTFTGTVD
EPQVGELSLGFGDVPFNIKNLSCETHKATGHIRIGWMRSVSNIQHAFAQGSFVDELAAKA
NISTYQMWQQLLGENRLVNPKTESFDYQNYGESLDVFPIDIKRLKHVLNDVIEKSGADGE
TSANEGWGISVHRSFVTYCAVATKVKVEENKVTVLEMHSSIDAGTIVNPDRVRSQQEGSM
IFGLSLALLGEISVKDGAVEQSNYHDYQVLRMSQCPKIETYIVESDAPPGGVGEPGTPPV
AASLANAIFHASGKRIRDLPIKNHMSV
>A0A0K8NVC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MPHYELALNGERVAVEADEDTPLLYVLRGACGLRGPKFGCGLGQCGACTVLLDGDAVRSC
VLPVSAIGALKVVTLEGLGNPRQPHPLQQAFIDEQAVQCGYCINGMVMTAAALLARTPRP
TEAQVCAALENNLCRCGTHTRIVKAVLRAGSGRPAGVRPSRTTTDATVA
>A9IS83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)|TrEMBL
MASLNINGKDTALDAPDEMPLLWALRDVANLTGTKYGCGMALCGACTVHADGVPIRSCVT
PLSAVTGKQITTIEGAGSDRVGQAVQAAWRKLDVAQCGYCQSGQIMSATALLAQNKQPSD
ADIDNAMAGNVCRCATYVRIRAAIHEAARALA
>A0A3G7C6L4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MNDLPLTRRRLLQAGGLIMISTLLPKSLLATADTKNPAALPADPTPDHVDSFIALDADGR
VTAFCGHVDLGTGVRTALAQLVADELDVDFEQVQMILGDTASTPDQGPTIASATLQVSAL
PLRQAAAQLRQWLLEGAAEILDQPIAGLQVERGQIYASARPKRRLSYAELARGQDLHLPL
DPRVELKAVGAGRYVGQSTPRVDIPAKVSGQLTYVHDLRLDGMLHGRVVRPPYPGADASA
PLGHALIAVDEASIAHLPGIVKLVVVGDFVGIVAEREEQAIDAMRQLKVQWKPWDALPDL
RPDALRKTLLAHPKQDRVLRDDPDFDSRLGTLNSPLNVDYVWPYHLHASIGPSCAVAMVD
AERAEVWTGSQNPHDLRKDIALLLGRAPQQVQVNRLEASGCYGRNCADDVAADAALLSQA
VGRPVRVQLMREQEAGWEPKGTAQLMQVRGGLDGKREVAAYELKTCYPSNNARTLALLLT
GTVANRPDIQQMGDRTAIPQYRFPQMRIVCQDAAPIVRASWMRGVSALPNVFAHESWIDE
LAYIAQQDPIAFRLRYLDDPRALALIEALKKQADWQDGSAHRHPAPPSQEWVKGRGFAYA
RYFHSKFPGFGAAWAAWVCDLSVNRRTGQVRLDKIFVSHDCGRMVNPAGVRHQVHGNIVQ
SCSRVLKEYVSFDHCGSTSLEWGGYPILRFDELPEVDVQLLDRPEEPSMGAGESASVPSA
AAIANAIFDAVGVRLRQVPFTPERVLQALQRAPDTDRLGQEARP
>A0A7W7QXC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kitasatospora kifunensis|TrEMBL
MEAQDPAPQPAGTDTGRGLGRRRFLGYVVAAPTLLVAAQVEQTALASTPAAAAVPSLPEP
ADLLDLTTLLTTAALPTSGLISIQLNADGTATFALPRAEVGQGITTSTAMLIAEELDIPL
AQVRITLADARPELLFNQLTGASNTTVSTYTPVRIAAAIARQRLLAAAAARFGVPVSTLT
TAAGVVSAPNGQHADYGSLAAAAASQSTIQVAVALKQRADFKVIGTAQQRIDALDIVTGR
KQFAMDLAIPGALPTMVCRPPTVNGTPRSVQNLAAVQAMPGVTDVVTIATGVAVRAKTFG
QCIDAVRALQVTWGPGTEDGSSDETVLQELKAAELPFAVPPVNLLAHTIDTTFTFAFASN
TALEPNCAIADVRPGRAEVWGSLKSPIVAQAAIAAKLGLLPSAVTVHVTQGGGSFGRKLF
FDAALEAAEISQLMGKPVKLMWHRTDEFRQGRTHPMSISRVRAVHALGQVLSFEQRHTSV
ATDFSHGLGEVLTALVAKLPVGDTAFSETIFGLSQQTPYNFGLTTQLLSEVDKGFNTGSM
RGIYSPNVRCAQELMVDQLAAALGADPYQFRRQSLKDTRAVAVLDQVAQLGSWGRTMAPG
TAQGIALHPEYHSVAAVLVEIDCTAQTTGRQIPDAYTGPRVTKVVCAVDAGLAVNPLGLQ
AQMMGGIMDGIALALSSGLHLSNGVFQEGSWDNYFYTRQWNTPPELQIVVMPPSGDTPGG
AGELAVGAAMAAVACAYARATGTMPTSFPINHAAPLAFDPLPTSPPIPQSPVDGLTRAY
>B3R3F0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MRDVQTAPKPPMNTPRPLTLQVNHAQHTLDVAPDTPLLYILRNDLCCNGPKYGCGLGQCG
ACTVLVDGLPARSCVLPVKAAVGHAVTTLEGLGTAQHPDPVQQAFIEEQAAQCGYCLNGM
ILTAKALLARNPDPDEAQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQATQGAAS
>B3RAI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MPRGRYWAAPEPAAAKPVRNEETPMKLQLKINGKRHAVDAERDMPLLWVLRDYLGYTGTK
FGCGAGLCGACTVHVDGKAVRACITPVGTVARADITTIEGLSVDNSHPVQRAWIAEQVPQ
CGYCQPGMIMAACAFLKDNPMPRPEDVRAGITNLCRCGTYPRVERAILRAATALNAGEPK
GRASS
>A0A7X6J7B1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MINNLHSRRNFLRGTVLATGGLVLSVQLPRFGRAAAAAGQENQKSFFPNAFIKIDDDGIT
LIMAHHEVGQGIFTSSAMLMAEELEVGLDQVKLQAAPPDLSKYLDPLLFDQSTGGSTSTR
ADWMRLRQAGAAARTMLIQAAASDWSVPAFECRVDLGVVHHDATGRSMTYLEAAPKAAAL
PVPENVVLKEPSEFRVIGTRAKRLDTPHKVNGSAIYGIDIIIPNMKFATLAISPVVGGRI
LKMNENAARSVKGVRDIVKLPDAVAVIGDHMWAAKAGVDALEIEWEAGANGSMNLNSIVK
KLAQASQQQGVIIRNDKDAAAVISNAAVKLSAVYESPFLSHSPLEPLNCTLHIQDHKAEM
WVGTQVPVRAQKAVAEATGLPQESVVVNNQLIGGAFGRRLDVDSIELAARLLKDIRYPVK
LVWTREQDMTHDYYRPYYYDRVAAGLDEDGRLIGRTHRVTGSSIFARYAPAAFIKGVDPD
AIECASETPYDEDAVFVDYVRNEPDGVNTSWWRGVGPSHNLFVVESFVDEMAAAINQDPV
EFRRRMLTKNPRALAVLNEAAEKAGWGEKLPAGRGRGVSLQVAFGSYLAHVLDIEITKEE
VKLLRSVIAVDCGMTINPDTVEAQMQGGVIFGLSSAMYNQVTFTEGAVDQTNFDMYRALR
INEIPKIEIYHIKSQESPGGVGEAATAAAAGALANAIFAASGKRIRSLPLAEAALS
>B4EFG5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)|TrEMBL
MSADTRIARPGRRRFLLGAVGLGGALVVGWGVMPPRSRLGDPAVFPETSGQIALNGWIKI
TSEGNAILAMPRVEMGQGIHTGLSMLAAEELDIPLTRVSIESSPIERIYGNVVAMGDSSL
PLHPDDADKLWARALHWIMAKSAREIGLIITGGSSSMADGWQPVREAAATARATLVEAAA
REWGVQSTLVTVREGQLIGPGGKQMPFSAVAQKAREIAPPSNVTLKPASQYQLVGKPAPR
NDIAAKTDGSARFAIDVRPSGMLYAAVVMCPIFGGKLKTFNAKAALVMPGVRYVVPFDGS
TGGAPGVAVVADHYWQARQALGALEPEWDNGPHATLDSADIHQQLVGALNSDKGSFTYRS
TGDGLKAFENAQGATIVEAEYSAPYLAHATMEPINCTAQVTKNRVQLWAPTQVATLAQLV
AARAAGVSRDQVHIEIPLIGGGFGRRLESDFVGQAVTIAARTAGRPVQVIWSREDDIKHD
FYRPQAIARLKARVENGRVTAIASRSAGQSILAGELERLFGAPSLDIDRYTAEGLFDQPY
EIEHEHIAHLVVDLPVPIGFWRSVGHSYTGFFLESFLNDVAAAAKLDPLAMRRDLLKAHP
RERKVLDIAAQTAGWGQPLAPAADGAPRARGLALHNAFGSVVAQVVEVSLKDGKPRVHRV
VCVADCGTVVNPGIVAQQMEGGIIFGLSAALYGQIQIKDGRVIQSNFPDYPVLKMAEAPA
IEIHVVPSTAEPTGVGEIAVPPVAPAVAHAVAQLTGKSVRQLPMV
>A0A7W4VA24|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus alkaliphilus|TrEMBL
MSHLHTSRRRFLQAAGAMPAALVLGFHLPLAKAADARAPARDPDDVNAWLRIDADGGVTI
MVPSAELGQGVMTSAPMLIAEELACDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQSWSVPVAQCRAAQGVVRHEPSGRTLGYGALAARAATLPR
PASVALKEPRDWKLLGRPTDRLDVPLKTRGAAVFGVDVRVPRMLVGSVMACPAFGGTLRR
VDAQPALALRGVRRVVPLDDAVVVLADSYWTARNGLAALQPEWQLPQGKLAGDAALMAGY
RDAARHASAVALRHGDPDAQLQGTQPYTAEYEVPYLAHATMEPMNATADVRADRAEIWGP
TQVCGEIAQRLSGALGLPAERIAVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPDAAGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAKADPLQFR
LKLLADRPRPARLLQRLAQHVGWGSAPAGRCHGVALSQAWGSLCATVVELSVQGQRITLH
RVVNAIDCGTVINPATVERQLEGASIWGLSAAMTGAITIADGRVQQSNFHDYPLLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGQRLRSLPLARHGFELA
>A0A165UNG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio axinellae|TrEMBL
MSVSTSRRGFLKGAAASAAAVLVIGAAPSGVMAATNGFDTTMLNPFVRIASDGTVTAIVK
HFEKGQGPATGLTTLIAEELGVSMEAIEYEFAPSNPKLYNNTAFGPFQGTGGSTAMFNSF
LQYRQAGAAAREVLLQAASQAWELPVEQLKLEDGVIIGGGETAPLGEFVQAASQLEAPEN
PRLKDPSEFKLIGNASIHRKDTPPKVNGTAKYAMDIQLDDQMVVAVKRAMRRGALAVSFD
DSAALSVKGFIRAAMLPNKAGVVVYADDTWAALQARDAIEVTWDYSAAESRSSEDVYKEL
MAAVNSEPEYNLTKNDQGTVAAAIENADKVVEETFYFPLLAHAPMEPLTCTIEPTQDGGV
VLHDGSQMPTSPHMVLSKVLQLPMEKVQINTMFAGGSFGRRATPTVDYQTEAALAFAMTD
RSRPVKLVWSREDDITGGYYRPAFAHKVRVGLDSTGNIVGWDHRVAGQSIAKGTPFEAFA
VHDGIDDMSVEGVTPTPYSIPGMFAGLTDTKAATSVLWWRSVGHTHTAYVMETMMDATAA
AAGRDPVEFRLAHLSGDVPEQKRMANVLKLAAEKGNWGKAAEGRSQGIAVHSSFRSYVAE
VVEISGDAEAGVKIEKVTCAVDCGIPVNPDVIKAQMEGGIGYGLGHAMRDEITLEEGEVV
QSNFPDYEPLRIGDIGEIETHIVLSTEAPTGVGEPGTPPSAPALANAIAVKGPRVTELPM
VNAGVNFA
>F5YHU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Treponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)|TrEMBL
MTLGFILNGEDVVVKTEADRRLLDILRNHFKLLGAKPGCLSGVCGACAVILNGKVVSSCM
IPAFRIRGSEIITIEGFSQTNEYQDIQEGFSRAGVENCGYCDSGKILAVETLLDKNLRPT
REDILEAFSGIKCRCTEPDSLIAGVFATAEIRQRRLYGRSA
>A0A7W6CZG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hansschlegelia beijingensis|TrEMBL
MIKLKINGEERSVDVDADTPLLWVIRDEIGLTGTKFGCGQALCGACTVHMDGQAVRSCQT
MVGDVGDAQIVTIEGLVGANATPEGKAVQAAWRALDVVQCGYCQSGQMMSAAALLAENKK
PTDEDINAALDGNVCRCATYQRIRAAVHDAARRLEA
>A0A375D6E2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSHLHASRRRFLQAAGAVPAALVLGFHLPLAKAADAAAPARDPDDVNAWLRIDADGSVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQGWSVPVAQCRAVQGVVLHEPSGRTLGYGALAARAATLPR
PANVALKDPRDWKLLGRPTDRLDIPLKTRGAAVFGVDVKVPRMLVGSVMACPVFGGTLRR
VDARPALALRGVRRVVPLDDAVVVLADSYWTARKGLAVLQPDWQLPQGEPASDAALMAGY
REAARSASAMALRHGDPDTQMQGAQAYTAEYEVPYLAHATMEPMNATADVRADRAEIWGP
TQVCGEIAQRLSGVLGLPADRIVVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPDAAGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAKADPLQFR
LNLLADRPRPARLLQRLAQHVGWGIAPAGRFHGVALSQAWGSLCATVVELSVQGQRVTLH
RIVNAIDCGTVINPATVERQLEGASIWGLSAAMTGAITIADGRVQQANFHDYPLLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGQRLRSLPLARHGFELA
>A0A375CBT9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHPVEAERDMPLLWVLRDYLGFTGTKFGCGAGLCGACTVHVDGRAVRACI
TPVGSVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLKDNPSPRP
EEIRAGITNLCRCGTYPRVERAILRAATAQNAGDPKGRASS
>A0A375BVV2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLDVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVRAAVGHAVTTLEGLGTAQQPDPVQQAFIDEQAAQCGYCLNGMIMTAKALLARN
PDPDEAQIREALRFNLCRCGTHVEIVRAVRRAALLQRQAAQGAAS
>A0A375D6F8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGTVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLQDNPSPRP
EEIRAGITNLCRCGTYPRVERAILRAATALNAGDPKGRASS
>K9NLP4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. UW4|TrEMBL
MNSINGLSRRGFLKGSAVLGGGLVVAFVMPGAHRFAMGAENQGNVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMPGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIHTESGVVVAGEHRATYGELADDAGQL
PPPDPASIKLKDAKDWRLIGKPTQRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPTFGG
SVKSFEGAEALAIPGVHKVVQVPTGIAVIADHYWAAKLGRDALKVEWNPGPNARLNSQAL
LESFRKLAATPGLNAGQAGDTPAALAKAAKTIDAEYSVPYLAHAPMEPLNCTVSISKDKC
EIWTGTQFQTLDQIVAGQITGLKPEQVEIHTEFLGGGFGRRANPTSDFVSEAVHVAKAAR
MPVKTVWAREDDIRGGYYRSAFLHHARIGLGADGLPLAWKHVMVGQSIMAGTSLEASMVK
DGIDKTSVEGVADSPYIGGLANHQIELHSPQTGISVLWLRSVGHTHTAFVVESLIDELAT
AAGKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLAIHVHRVVCAVDCGIAVNPQSIAAQMESCITFGLSFALHSKLTLKDGQVVQSNY
HDYQVLRLNEMPVVEVYIVPSSNKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>S2CXH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)|TrEMBL
MRPTFPFFKPKEETDSSKIFKPSRRDFLKLSALASGGVFLGISFQCSGPKGEDVIFAPNA
YLSIDKDNLITIIAHRSEMGTGIRTSLPMIIADELGADWSKVKIVQADGDEDKYGDQNTD
GSYSVRMFYEPMRKAGATARHMLLMAASQKWKVAMDECYAENGMVHHPGSEKSINFGELI
SDVQKMEIPRSEDVILKPFGDYKLIGKDIPIYDVKDIATGKAVFGADVDLDNMKIAVVSR
SPVVGGKVISVNDSAALAVNGVEKIVKIEGAGLPAGLDKPLEGIAVIATNTWAAIKGRNA
LEIEWDLGENQGYDSVAQLKDMLESTKESGKVRRERGEIEEAVKSTSRTIERTYELPYYA
HATIEPPAAVAHFTNGKCEVWAPTQHPQWARGAVASALGIEVADVTMHVTLLGGGFGRKS
KPDFVVEAAILSKEMGSPVRVQWTREDDLHHDFYHALSAQRIKASLDGSKNLVAWNHHTV
FPAIGATSNPAEVHPSDGELGLGCVDFPYDVPNIRIETHESKAHTRIGWLRSVSNIHHSY
AINCMMDEVAEARGVDPINHALELLGEDRNLSFKEELDGDFSNYGESIEEYPWETGRMKA
VIQRVAQEAGWGQNLGGNKAMGFACQKSFLTYVACIVVVEKGGDGKIKVSDVHYAVDCGI
AVNTDRIRSQFEGGAQFAHGLATSSAITFKNGKVEQHNFDSYQIARMPEAPKRIHVYIVD
SMEKPTGVGEPPVPPYAPALANAVYKLTGKRQYKLPFKI
>A0A1L5PID2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli 8C-3|TrEMBL
MTSLKVNGQTHEVESEPDTPLLYVLRNDLGLNAAKFGCGLGQCGACTVMVDGQAVLSCVT
PIVVVEGKEIVTVEGLGTAEKPGPLQAAFIEKQAAQCGYCIAGMMMSAAVLLKQNATPSD
EEIRSALRTNLCRCGTHMRILAAIRRAGELMEASGLVGAKRSAG
>A0A1L5NSA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium gallicum|TrEMBL
MTAFTINGQAVDVAAEPDTPLLWVIREHLKLTGTKFGCGIAQCGACTVHIDGEPTRSCQT
FLEDVAGREVTTIEGLSPDASHPLQKAWISEQVPQCGYCQSGQIMQAAALLEHTPDPTRE
QIIAHMDGNICRCGTYVRIISAIQRAAQKG
>A0A0M9GCN9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fuscovaginae|TrEMBL
MSSKTEFGRRAFLQGSSLLMAFTLMPAARKVLADTEVDTLGTAVLAPDLPGSLRTNPYLD
AWIRIGAEGITVYTGKVELGTGVRTALLQIAAERLDVAPGKVNFLTADTALTPNEGYTAG
SHTIFDSGTALFNAAAQVRQMLLDSAARQWGMDVATLKTGDAMISAPSGARMSYADAVAG
VDLHQYAQARSPDISPEQFKLIGHAIPRLDIPAKVTGGAAFVQDMRLPGMLHARVIRPPR
PGSQLTAFDARAIEDLPGVVAVLRDGNYLAVVAGDEWQAVKAMRAGYESATWSGGEVIPD
QAIIHQLLPRLPSRRYPIRHDGTASPSAGRTYRARATKHYLMHGSIGPSCALAWFKDGTL
TVWTHTQGVFPLRAGIAEMVGLAVTAVRCIHVEGAGCYGHNGADDAAADAALIAMRVPGV
PVRVQWMREQENLWEPYSSAMITELEASLDRNGRIGNWKYELWTTPHNERITNAGRLVPA
RMLARPFTSMPSIPIAQPEGDGDRNAIPLYETGSSSIDMNFITQMPFRTSAMRSLGAHIN
VFAIEACLDELAGQAGVDPVEFRLAHLGDPRARAVIERARDEFGWPRRGAVPGSGIGMGF
ARYKNIMGYCAVAVEIQVHPQTGEIGIERVVTAVDVGQIVNPDGLRNQVEGGIVQSSSWT
LFEAVSYDAGGVRSYDWSGYPILRFPQLPRHVEVHMIDQPGQPFLGAAEIVQGPMAAALG
NAIADATGHRRLALPLARTLDKEG
>A0A380B487|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MAIAEVQLPREGAVKTLTEHPLMLSVNGENIHTRVMADTPLLLVLRNDLALNGPKYGCGL
GECGACTVLVDGIAARSCVIPALGVTGRAVTTLEGLGDRDRLHPVQRAFIEEQAAQCGYC
LNGMIMTTKALLDRNPSPSDREIRQALSGNLCRCGTHIEILRAVQRAIILCRSEETSPHD
>A0A3G7JY23|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIETDEVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHNAAPSDA
QIDAAMVNLCRCGTYNAIHTAVHDLAAQPAKKESA
>A0A1X7A4D4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax jejudonensis|TrEMBL
MTAQTRRQFLASAAGLVIGVALPLRARAQSGAAAAIGDGTIAEGGFAPNAFVRVAPDNTV
TVISKHIEFGQGPYTGLATLVAEEMDADWSQMRVESAPADNDLYANLAFGIQGTGGSTAM
ANSWMQMRQAGAAARAMLVAAAAERWGVDASAIRVSGGTLTDGTRTASFGELAEAAAGQS
VPVEPAVKNRDEFTLIGTDRPKLDSRAKSDGTAQFTMDVYRDGMETVVVRRPGVIGATVA
SYDDTAARAVPGVVAVHRIPQGVAVYATSTAAALKGRAALEVTWDTSEAETRSSDEIFAA
FREMAEGEAIEAERTGDAAAAIAGADTVHEAEFLFPFLAHAPLEPLDAVLELRDGKAEVW
MGAQFPTADAGAVTQVLGLDPADVTMNVMLAGGSFGRRAQPTAHIGVEIASIAKARGGDG
AWKLVWTREDDLTGAYYRPITLHRLRAGLDSEGNIVGWENRVVNQSIIAGTPFDQGGLDR
TSVEGAIEMPYALPAIAVDWVKADLPVPPLWWRSVGHTHTAYATEVFLDELLERAGRDPV
QGRLDLLRPEATRDRAVLERVAEMAGWTGARRRGDRALGVALHESFQTYAAQIAEVSDAG
GMPRVHRVWCAVDCGTAINPNVIRAQIEGGIGYGLGAILHNALDLGPGGEVRQRNFDTYR
MLRITEMPAVEVAIVDSDADPTGIGEPGTPPIGPAVANAWRVLTGTSPRRLPFAQTGV
>A0A1K0IPG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator|TrEMBL
MPDHQISVNGKSVEVRSDGCTPLLWVLRCELKLTGTKFGCGVGVCGACAVHVNGKMLLSC
QHQASEMEGKKIVTIEGLDGPEASALRAAWLKHEVVQCGYCQSAQLMAASALLKRTRNPK
ETEIADQMSCVICRCGTYTRIRRAIAEAAGMLRG
>A0A1Y6KCX7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MTKIHVNGRDYEVAAEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQV
PLDSIGTSDIRTIDAIEQDGIGRKVVEAWVADQVPQCGYCQSGQVMAATALLKQNPRPSD
ADIADAMTNLCRCGTYNRIAAAIRRAAQA
>A0A1L7I2G2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gramella flava JLT2011|TrEMBL
MSKVKTGIGRRSFIKSVSLAGGGLVIGFNWMACKRAAEAEAEGTAVLEMPDEWFELNGYL
KVGDNGVVTIFSPNPEIGQNVKTSMPMIVAEELDVDWNNVVVEQAPLNTDVFTRQLAGGS
QSIRQGWETLRMAGATARQMLVMAAANQMEVPAEELTVENGVISHKNSDQSLGFGEVAGA
ASKLEVPTEVELKNNADFRIIGTSRKNVDAKKIVTGQPLYGLDTYKDGMLIAMIVQPPAF
GMELKSMDADKVKEMPGIVDVFTIDTYPEDMEKEWSDVAAFSKLAVVVGESTWQVLKAKK
ALNVEWDLNPELTKEIEILEKSAGMKDATGLENTDIHYSLMADVGSKKAEVVRKDGEPEK
AFENAARVIERSYTCPFLAHNTMEPMNFFADVSGGKAELVGPIQTPEYAEKSIQKRLGME
LEDIDVQMTRMGGGFGRRLYGHFLVEAAVISEKMGKPIKLVYTREDDMTNGVYRPAYHVT
YRAALDGNNNLTAFHVNAGGIPESPLFANRFPAGALDNYLAESWTLDSNISVGAFRAPRS
NFIAGAEQSFLDELAEEMGKDPIEFRLEMLDRAKNDPVGEENDYDPARYAGVLEMVRDKS
GWTSNSSTGARGVSAYYCHNSYVAQILDMSIENNEPVIDKVVCAVDCGIVVNPDAATNMV
EGGTIDGIGHALYSEMSFKEGVPQMSNFDKYQLIRHKQAPKAIEVHFVENGIDPTGLGEP
PFPPVQGALANALYKATGQRFYKQPFINQLKNTSSDLKT
>A0A1Y6KMK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MTRAPIRLTVNGQTHDVAAAPDTPLLNVLRNDLALNGPKYGCGLGECGACTVLIDGRAAR
SCVIPIEGCAGRSVTTLEGLGSRETPDPVQQAFIAEQAAQCGYCLNGMIMTTKALLAIKP
DPSLDEIKQALRYNLCRCGAHVEILRAAMRAAGHTLEALD
>Q48A68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Colwellia psychrerythraea (strain 34H / ATCC BAA-681)|TrEMBL
MIKITLNNKPVELDVDPQMPLLYALRDELKLTGTKFGCGAGQCGACTVHLNGTAIRSCIT
PVSAVAEQAITTIEGLADSTGRLGESAVQVAWREFKVPQCGYCQSGQMMSAAALLKATPQ
PTDEQIIEHMQGNICRCGTYQRIKAAIKSAAAHSPNSDLSASHSPVNKNGVEIFDASKQG
A
>Q398Y5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MTIELDNTGSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATPPAADFAPNAFLR
ITPDGAVTVIAKHVELGQGAYTGIATIVAEELDADWSHVRVESAPADAKRYANLAFGTMQ
GTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWKVPASELTTANGVVTHAKSGKTAAYG
TLVADASKLPVPDKVALKQPADFKLIGHRIPRVDASAKSNGTAHFTLDTTFPGMRVALLQ
RPPRFGAKVKSFDATDAKAVPGVVSVVQVPGGVAVVGTGFWAAKQGRDALKVEWDETNAE
KRGSDEIMHEYRQLADKPGTSARKDGDADAAITGAARKISATYEFPYLAHAPMEPLDAVV
KLTANSCEIWAGDQFQTVDQANAARTAGLKPEQVQIHTLYAGGSFGRRANAWSDYVVEAV
SIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGKLVGWRHRIVGQSILA
GTPFEAFMVKNGVDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYAVE
AFIDEAAHTAGKDPYAFRRDLLAKEPRMRAVLDLAAQKAGWDPAKPLPKGRGRGIAVAEA
FKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIVAAQMEGGIGFGLGAVMHSAIT
LKDGQVEQRNFDGYHVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPVGPAVANAIFAATG
KRHYVLPFDSADSAKA
>A0A6L5C4Q9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas frederiksbergensis|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A7W8RR76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. Cpub6|TrEMBL
MSQGLLDAQNGAQPADTDTRHARGISRRGFLKFGVTVGAAAGGGLLLGFSMPAASQDQKA
GKSVIGGDANEAPQNGVFAPNAFIQIDNAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LDTVTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARVMLINAAAQQWQV
DPASCHAQAGQVIHPASNRSASYGQLAQAASALPAPQNVPLKDPKDFKLIGTPAKRLDSP
EKVDGTAQFGLDVRLPEMVYAAIANCPVFGGTLASVDDTHAKTIPGVREVIKLDNAVAVI
GAHTWAAKRGLQALDIKWNEGAGAQVSMQRIVDDLAAASQHGGAVARKDGDVGRAFGDAK
SRVDAVYQQPFLAHATMEPVNATVHVRGDACEIWLGSQVPTRVVDAAVAVTGLPADKIIV
HNHLIGGGFGRRLETDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDTISAGLD
ANGKPIAWQHRIAGSSIMARFAPPAFKNGLDPDAVEVAADLPYDLPNQLVDYVRVEPHAV
PTAFWRGVGPTRGTFVVESFIDELAAHAKIDPVQYRRDLLGKSPRALNVLNLAAQAGNWG
SALPKGQGRGISVMHAFGSFFAIVVEVALEQGEVTVKRVNCAVDCGMFVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIDVHIVKSGEAPGGIGEPGTA
ALAPALTNAIYAATGTRLRQLPVGRQLHSA
>A0A7W8RJU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. Cpub6|TrEMBL
MGEIVNLSRRGVLKGTLAGGVVLGLQIGGAGTALAASVLSSANGAKAAFAPNVYVSVAPS
GEIILVAHRSEMGTGIRTSLAMILADELDADWNAVKVVQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGTARQMLVAAAAVQWRVAPATCHTEPGHVVHAASGRRVAYGALATAAARQPV
PGRDTLHLKDEGTWRYIGKSLPIVDLDDIVHGRATYGIDVVLPRMTYASIERSAVYGATL
KSVDSTETMKVPGVLHVVRIPAAPLPAGFQPLGGIAVVATSTWAAMQGRRKLRLDWDLGP
NASYDSQAYRKALEDTARQPGKIVRNNGDTAAALKSAAHHVSADYYVPHLAHAAMEPLAA
TASYANGAVEVWTATQNPQQARTTVAQVLGVQEPAVTINVTLLGGGFGRKSKPDYVAEAA
FLSREVGAPVKLTWTREDDVHNDYFHAVCAQHMEGGLDAQGKTVAWLHRTVFPSISSTFK
ADVRYGAAGELGQGVTDMAYDIANVRCENGAAFAHTRIGWYRSVYNIPHGFALGSFVDEL
AAAARQDPVQHLLTLLGTPRHVDLHALGVDYPNYGASIDKYPIDTARYAAVVRAAAVRSG
WSTALPARHGRGIAVHRSFLSYVAAVAHLQVADDGSVRVTRVDLAVDCGRIVNPDRVVAQ
FEGAVVMALGNTLYSELTFRNGASEQSNFTDYQVARIDSVPETHVYIVPSDAPPGGVGEP
GVPPTSAAICNAIFNATGQRIRALPVDTSLLKRT
>A0A846UK49|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MYSSSAGVVITRRGLLTSSAAAGLVVAFHIPFADEAAAQASPAGITPAVATPEINAWVVV
QPDETVVIRIARSEMGQGSLTGLAQLVAEELDCDWSRVKTEYPTPGQSLARKRVWGNFST
GGSRGIRESHDYVRKGGAIARTMLVQAAADGWQVPAAQCQVDRGVITHAASGRKTTYGKV
ALAAARLTPPADVALKDPKDWKLAGKRLARLDTRGKLDGSQVYGSDLKLPGMLNAAIRDC
PVFGGKLASFDAAAIAGKPGVKKVLRVGDSAVAVVADTWWRAKSALDALPVVWDEGPNAK
IGSAEIAATLAAGLDAPEAAVGNSNGDARAALASAARVVEAVYAYPFQNHATMETMNATA
KFTPASDGVPARCEVWTPTQNGEAAHAATVEASGLPAGQCEVYKLLLGGGFGRRGAVHDW
VHQAVAIAKEMPGTPVKLIWSREEDMTHGRYHPITQCKLRAGFDAAGNLSALHMRISGQS
ILAGVFPQNIRDGKDPVVFQGLNAPGPEASIGYSVPNLLIDHAMRNPHVPPGFWRGVNLN
QNTIYLECFIDELAHATKQDPLAFRRKLMAQHPKHLAVLNAAAERAGWTRPAAKGVYRGI
AQTMGFGSYVAAVAEVSVDKDGKLKVHRIVAATDPGHAVNPQQIEAQVEGSFVYGLSAAL
YGGCTVKDGRIEQTNFDSYPVLHLDEMPKVETVVMPSGGFWGGVGEPTIAVAAPAVLNAI
FAATGQRIRELPLKNHSLKKA
>A0A846UR09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MDLTVNGQTLPLPPDAVEPDMPLLWVLRDVLMLTGTKFGCGVAACGACTVHVDGQAVRSC
VTPLSAVQGKPVRTIEALGVPGQPHALQQAWIAHQVPQCGYCQSGMLMAAADLLARNPSP
TDADIDAAITNLCRCGTYPRIREAIKGAAAALRGEPHRSDRSNEARA
>A0A6T9XZG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alteromonas macleodii|TrEMBL
MITFTVNGNKHEFSGDPSTPVLWYLRDELNLTGPKFGCGMAQCGACTVHIDGMAQRSCVL
PVSAVQGKKITTIEGLSDNGDHPVQKAWVEHKVPQCGFCQCGQIMQAASLLSTNPTPSDE
EIVQNMSGNICRCGTYPRIHKAIKSASKSMSGNAGVSYFDPSKTGEEA
>K6ZCM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola arctica BSs20135|TrEMBL
MSQYFDLTRRSFLKSSAAAGVLVLGTYFAGAAPRVMAGVLAKPSESAKTANLFVALRPDG
IVEITCHRSEMGQQIRTALAQIVADEMEASWDKIVVIQGKGDLKYGDQNTDGSRSIRYNM
QRLREMGASVRYLMRQAAATRWNVPIDSCSAQQHLVTHSSGKTLTYAELVNDALSITPPE
LDKILLKKRSEWRYINTAMEHIDLKDIVKGKAIFAADVLEPKALIAVIVRPPVVGGKVKR
FDAKAAKAIKGVVDVIEIPAPKGAPLFQPKGGIAIVANNTWAAIQGRRALSVTWDDGKNG
DYNSEAFKASLLATVSSPQSSVREIGDAATILAKASDKLVADYYAPHLAQAPMEPPCATA
MYYKDRVDVWAATQNPQADMATVGAMVGLPKEKINVQVTMLGGGFGRKSKPDFSAEAAYL
SMKTGQAIRVQWTREDDIQHSFYHAVSAQHIEASLDKNGAIEAYLHRTAFSPIASTFQEG
ATAPGSFELRLGFTDNPINTPNMKLENGEAPAKARIGWMRSVSNIFHAFAIQSFIAEAAH
KAGRDQKDYLLETIGPARIVDVTEQNAQYDNYGADKATYPLDIGRLRHVIEKAADMSGWG
RKLPKGRGLGIAAHRSFLTYVATVVEVEVSDSGELKIIKSWASIDAGTVVNTDTVINQVQ
GGSIYGMTAAISEGITFDKGRVQQSNFHDYRVPRMSDSPLEIEVEIIPSEAPPAGVGEPA
TPVYAPALCNAIFAACGKRIRQLPIGDQLKA
>A0A2H6A3L1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR33|TrEMBL
MATTLRVNRREFLKVSALAGGGMLIATYWDPWNRLLAAESAAEFAPNAFIKITPDGAVTI
IAQNPEIGQGVKTMLPMIVAEELDADWRAVRIEQGDLDTEKFANQYAGGSTATPNHWEPM
RRAGAVGRAMLIAAAAKTWNVPQSECRTEAGTVIHRPSGRRLSYGELASRAATLPVPDPA
SVPLKDPKDFKIVGKPLPGVDVRAIVTGAPLFGIDVSLPGMKYAVFEKCPVFGGKVRAAN
LDEIRSQPGVLHAFVVEGGSDLSGLLGGVAIVGETWWAAHQARQRLRVSWDEGPTAAQSS
DWFTQKAAELFRQPPHRTLRRDGDVDAALRSAHKVVEAEYSYPFLAHAPLEPMNCTAWFR
DGELEIWAPTQTPERGRTLVSRTLEIPPEKITIHITRSGGGFGRRLNNDYMVEAAWIARQ
VAGTPIKLVWSREDDIRHDFYRPAGFHRLTGGVDRNGKLIAWRDHFVTFGEGERFANSAN
ISENEFPAAFIPNFALEVSLIPLGVPTGALRAPRSNGLAFVFQSFIDELALAAGRDPVEF
RMDLLASAGEGAAMNAERMRGVLELVAEKSGWGRRSLPKGTGIGVAFHFSHRGYFAEVVQ
ASVSAAGEVKVEHVWVAGDIGSQIINPSNAENQVQGAVLDGLAEALGQEITIDRGRVVQS
NFHDFPLLRMVQAPPEVEVYFRRTDYPPTGLGEPALPPVVPALCNAIFAATGKRIRSLPL
SRQDLTWTAE
>A0A7Y7HXM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MNARRDFLKMAGGLVVAFHIPFDALAAEQPPIAKGASGATPEVNAWVVVKPDDTVVIRIA
RSEMGQGTLTGLAQLVAEELDADWSKVTTEYPSPGQNLARKRAWGSFSTGGSRGVRESHE
YVRKGGAIARTMLVQAAADAWQVSASECAASAGVITHKPSGRTVSYGKVADAAAKLTPPT
EVALKDPKDWKLAGKRLARLDTVDKTTGAQVYGMDIKMPGLLNAAIKDCPVFGGTVKSFD
AAVIEKRPGIKKVFKLGDSAVVVVADSWWRAKSALDALPIEWDKGPNAKLSQKDVAATLK
AALDAPDAVVGNANGDARAAIKSAARKIEAVYSFPWQNHATMETMNATAIWTPERCEVWT
PTQNGEAALAATAEAAGLPAAKCDVYKMHLGGGFGRRGATHDWVTQVVKIAKEMPGTPMK
LIWSREEDMLHGRYHPITQCKLTAGLDAKGNVTALHMRIAGQSILASLGSTLKDGKDPVV
FQGLNAPGPEASIGYSFPNLLVDHAMRNPPVPAGFWRGVNLNQNTIYLECFMDELAHATK
QDPLAFRRKLMADHPKHLAVLNAVAEKAGWGKPAPKGVYRGLAQTMGFGSYVAACAEVSV
DRKTGKVKIHRIIAATDPGYAVNPQQIEAQVEGSFVYGLSAALYGECTLKDGQMEQQNFD
TYQVLKLEDMPKVESIIMPSGGFWGGVGEPTIAVAAPAVLNAIFAATGKRVRDLPLKNTS
LVKKA
>A0A1P8US83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger abyssi|TrEMBL
MVALMVNGTPVELTGLDDKPLLWVLREDLDLLGPKYGCGIAQCGACRVLIDGVSTPSCVT
FLGDLEGASVVTVEGLTGPEDALSIVQRAWLEEQVPQCGFCQPGFIIAVTALLATTPRPT
DAEIDETITNICRCGTYPRIRRAIHRAADMMAEG
>A0A1S1HHE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas haloaromaticamans|TrEMBL
MTTRFTINGRAVSVDADEDSALLWAIRDDIGLTGTKFGCGIGMCGACTVHVGGRATRSCI
TPLAAVEGADITTIEGLDPAGAHPVQKAWRALQVPQCGYCQPGQIMQVAAMLKDFPAPTD
ADIDAVMAGSLCRCMTYVRIRAAIKEAAATMTKGTAKAKGAAA
>A0A840HM09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ERR14|TrEMBL
MANLTINGKTFTLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHIEGVATRSCGV
SVSEAEGKKITTIEGLASGDALHKVQEAWIAQDVPQCGYCQSGMIMAVAALLSEKPKPTD
ADIDEAITNICRCGTFQQVREAIHTIASA
>A0A6J5GFG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MTTFNINGQTHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVF
PAAAVGERKVVTIEAVGSTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLLASNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGV
>A0A654C2F7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. 8Z|TrEMBL
MITLNLNGTDHQLDVADDMPLLWALRDVANLTGTKYGCGMALCGACTVNVEGQPTRSCVT
PVSAVVGKRISTIESVGEDAVGKVVQQAWRELDVVQCGYCQSGQIMAATALLSSNKAPTD
ADIDAAMSGNICRCATYVRIRAAIHEAAEQLA
>G8TEH7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Niastella koreensis (strain DSM 17620 / KACC 11465 / NBRC 106392 / GR20-10)|TrEMBL
MITLTVNNQSYKVDVEPAMPLLWVLRDVLHLTGTKYGCGMAQCGACTVHLNGEAVRSCVT
PVSRAVNQKVITIEGLSANSSHPLQKAWAEEDVPQCGYCQSGQIMAAAVLLRENPNPTDQ
DIDNAMSGNICRCGTYQRIRKAIHRAASLQKEGGVQ
>A0A7Y9IZJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pigmentiphaga litoralis|TrEMBL
MVDFVLNGKPVSADVADDKPLLWIIREDFNLTGTKYGCGVAQCGACTVHLNGAPTRSCVL
PAAAVAGMQVTTIEGVAATAEGKALSAAWVAQQAPQCGYCQSGQIMTAAGLLKDAKGPLT
RDAVLEGMAGNLCRCGTYNQIAAAVISVHKASA
>A0A839ZX29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phenylobacterium haematophilum|TrEMBL
MADGSQLLSASRRDVLAGAGLVLSFTVAGKAGAAEAGGAGGKLNAYVRVAPDNSVTIVSK
NPEVGQGVKTMLPMLIAEELDVDWSQVRTEQAMNDFATYGRQFAGGSMATPLHWDELRRV
GAAARMMLVAAAAQGWGVPATECTTASGVVHHAGSKRKATYGSLATKAAQITVPDLKTVP
VKDPKDYKIIGQPLRQVDTDAIVTGKPLFGIDVVVPGMLYATYEKAPVFGAKVAGADLAA
AKGVKGVRDAFVVEGGTALDGLLPGVAVVADSWWAARKGRDQLNTRWVEHPTAAQSSAAF
AAKAVELSKAAPGKTERNDGDVEAALKGAAKTVEAAYAYPFISHANLEPQNCTAHFKDDK
VEIWAPTQNPEPGRQLVAKTLGIAPEAVSIHMVRGGGGFGRRLMNDYMVEAAWISKQAGA
PVKLLWTREDDMRHDFYRPAGWHFLKGGVNAAGDVVGWHDHFVTLGENGTAARSAGMSPT
EFPARFVPNYRYDLSMMPCGVPTGPLRAPGSNAIAFVVQSFIDELAHAAGADPVAFRLKL
LGEKPMVGDAPSGYAAGRMAAVVKLAAEKSGWGRTLPKGSGLGIAFHYSHLGYFAEVAEV
AVAPDGAIKVVKVWVAADVGRQIINPFGALNQVEGSVLDGLSGALHQKITIENGAAVESN
FTDYGLMRINEAPPIETHFIKSDNSPTGLGEPALPPIVPALCNAIFAATGKRIRQLPIDT
AMLKSG
>A0A5B8RHL8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured organism|TrEMBL
MNTPVDDLLLANVSRRHFLKGLAAGSALVLAARWDLALGEEEKEYGADAMPHGWVDDPNV
FIRIDADGTVTVTNHRAEMGQGIRTSLVMVAADELGADWDRVRVEQAPADQEKYGNQNTD
GSRSMRHWFAPIRRAGAAARMMLERAAAERWGVPASECHARVHAVVHAASGRELGFGDLA
AAARELSVPPRERLELKPQSEWRYIGEDAGPAYDVKRGSVVRPKAIDGEDIVTGQAVYGA
DVVFEDMLYAVVARPPVYGAMLRSVDDGEALKVPGVLRTVEIDGTGQPAGFKPLGGVAVV
AENTWAAIQGRKALKIDWNLESAGDNAAYDSEAYRKQLQQTARAPGKVIRDEGDIESALA
DAAERVSATYYMPHMAQAPMEPPVAVARIVNGRAEVWAPVQNPGATRSGVAKRLGLEPED
VTVNVTLLGGGFGRKSKPDFAQEAASLTKAFDGRPVRVQWTRDDDLHHTYFHAVSVDRLE
AGLDADGRALGWRHRTLSPSIGSLFAPDPEHIAPFELGQGFNTMPFDIPAIRLENPEAPA
HVRIGWFRSVYNLPHAFAIQSFAAELAEAAGRDHRDYLLELLGPSREIDPRTFGDPWNYG
ENPERYPIDIGRMRAVIEKATAEAGWGRDLPKGRGLGLAVHNSFVSYTAVVFDVELGDGG
GLIIHSADIAFDCGPQVNPERIRAQLEGACVMGIGIAMQSEITFSEGRVQQDNFHQYLVP
RIDRAPRETRVHLINPDSEAAIGGVGEPGLPPVAPALCNAIHAATGRRIRRLPVGDQLSA
>A0A840GCR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR18|TrEMBL
MPTLTINGRSLSVDAANDTPLLWAIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
MLSDVAGKKITTIEGLSAKGDHPLQKAWVAEQVPQCGYCQSGQIMQAASLLSKNPNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAASEMRTASATSTERRPT
>G3A6T6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia syzygii R24|TrEMBL
MELDVNRRPVKVECDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VVAVAGKRITTIEGLAEVPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADIDAAITNLCRCGTYPRVRTAIQRAAKALREGRA
>A0A177GBB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MEVAVEKNGQIRLIQAHSAVDCGPIVFPDGIVAQIQGGLIFGLTMALYNEITLKDGRVEQ
TNFHNYRMMRLNEAPDIQVHLVSDPDAEIGGIGEVGTVAAAPALANALFAATGKRLRRIP
FAKQLGGEKA
>R7ZYJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lunatimonas lonarensis|TrEMBL
MATYTLTINGARQTVEAPSDMPLLWVIRDLLGMSGTKFGCGQALCGACTVLLGDVAVRSC
SLAIADVGEQPVTTIEGLSSDGSHPLQKAWIDHIVPQCGYCQAGQIMNAAALLKRNPKPS
EEEIDQAMAGNLCRCGTYNRIKDAILSTNS
>A0A6S6XWH1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Denitratisoma oestradiolicum|TrEMBL
MVKIKVNGEERTLDVDPAMPLLWVLRDELVMTGTKFGCGVGACGACTVHLDGVPVRSCGL
PVSSAVGKNVTTIEGLVGKIAKSLQAAWVSENVAQCGYCQSGQIMTAAALIATNPTPSDK
DIEAAMSGHICRCGTYQRIKNAIHVTARQLHATPAPGDKS
>F7ZI77|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter litoralis (strain ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149)|TrEMBL
MQFTKPVELQATVKSPGPSRRSFLVGATGLVVAMALPIKGRTQALAAADAKFAPNAFIRV
SPDNVVTVLIKHLEMGQGANTGLAILAADEMDADWSQIRAEQAPDDPALYANLAFGVQGT
GGSTGLANSYMTMREAGATARALLVEAAAQTWGISAGDISVSTGVVTNETTGQTATFGEL
AERAATLPMPQDVQLKDPSDFKLIGAEGITRLDAADKARGQSTFSIDVMREGMQVVTVLH
PPKFGAVLSSLDASAALDVPGVNAVREIPSGVAVYGVDTFAALRGRDALIAQWDETNAET
RSSRDLEEQFLEAARSPARVAENIGDVDASLDQSERTFEAEYIFPYLAHAAMEPLDGVIE
WTPEQADVWSAIQIPTIAAPVFSSTLGVAPDAVSIHTMYAGGSFGHRSTPTNHFESELAH
VAAAAGPGAYKLQWTREDDMTQGYYRPLTVHRFRGGLDADGNITCWDNTVANQSIMAGTM
FEQALMTDGLDRTSYEGSTDLPYALPARRVSWAQMQTGVPVLWWRAVGHTHTAYATETFL
DELLIAGGRDPVQGRLDLITEDRPRDRAVLERVAEMAQWSGPGTGERRYGVALHRSFGSF
VAQIAEVEDRDGTPHVTRVWCALDCGVAVTPDVIRAQMEGGIGFGLSATLFEQLTLEAGG
TVRERNYGAYRVLGLEEMPEIMVDIMPSEVAPTGVGEPGTPPISAAVGNAWRAHTGQTPR
RLPIIGA
>A0A6J5FGS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinitolerans|TrEMBL
MRHNDQHGAARRRFLKQGSALLAAGLAVGFVLPEAHAAAAAESNISGDPHPQRGEFEPNA
WVRVLPDDTIKLVVHKHDSGTGTRTALAAVVAEELDVDPFRVEVITPEDPFFPQYIHPLW
KVFSTGGSTSVSLEYERLRRAGATARAMLIEAAAQQWGVPASACTTDNGNVVEAASGRRA
TYGSLAARAAKLPAPKDVALKPPGEFKYVGKLRKKRDAAQKTTGSFGYSIDVSLPGMLVA
VIARAPMIDGRVRSVDTKAALAIPGVRDVLRIPARPDILGGNQAGVAVLADDYWAAHRGQ
AALQIEWDDSPFESFDSSTLAARQAAWLNDPAARVVPTVQNGDAKTAQAAKAAGGKMIEA
SYTMPYKAANPLEPVNVTAWARNGGIEYWGGLQVPSSALEAAEVIGSIPENRVTLHELVS
GGSFGARESKYWLFEVTWLAIKTGKPVKLMNSREDEMRALYYHAATHHRARAVVDSKGQL
ASLELRAVSPASPEQWEPGYLDRADRMDYSTTEAINKWEFAYSAPHRDIGWVRHETGVPT
GWYRAVSYIPNVFAVESIMDEAAHAARRDPLEFRIAHMSERPRHVAVLREAAKRAGWGQA
LPAGTALGISTNEAYSSYIAVIARVKRKGDTVVVEKLTCVTDCGIAVSPGGVEEQLYGGL
MWGLGHATSDRIDIRNGRVQQSNFDTYRVMRMSDMPDIDIHLVQGDVSKPGGVGELAGPS
VAPAIANAVFSLTGKRLRETPFNLQMRA
>A0A840S9L1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Inhella inkyongensis|TrEMBL
MKRRHWLVMGLTAAGALGVGVGLRPPSARSRLGPPRTEGPRVALNAWVELDADGLVSVRV
PRAEMGQGVHTAFAQLVAEELEADWASLRVLDAPIAPLYANSALLLNMLPLQPDDQGPVA
LWVRGAAQRMGQVLGLQITGGSSSVRDAWEPLRLAGAAARQALLQAAAQQWGVDVSSLRT
AQGRVWAGERSLGYGELAASAATQTLPAEITLKNRRDWRLIGRSPPRLDLPAKVKGQAVY
GIDVRLPGLLHAAIRQAPVAGGSVVALDVAALKARRGVVDAFVLGESAAVVVADNWWRAE
AALKAHPPRFHAGPGAGRQSAEMSETLRRALDQHEGTGFREDGDALAVLAQADRVLRADY
ALPFLAHAAMEPLNCTAQVREGRVEVWCPTQVASLARWKAAEAAGVAQEAVTVHTTYLGG
GFGRRLETEVIEQAVAIALRLNGAPVRLLWSREQDFTHDVYRPMALARFEACLGPDGLPL
AWVNKVAGPSVSFGSVQRLAPGLAMDLPDKNHIEGAFELPYAIPNLRVRQIRRELGVAVG
SWRSVGHSLNAFFTECFLDELAQAAGQDPLRYREQLLAHRPRHLAVLKLAAAQAGWGQTP
AAGRARGLALHESFGSICAQVVEASLEPDGRPRVHRVVCALDCGTVLHPDTVRAQIEGSV
VFALTAALYGEITLVDGAVQQQNFPQQPLLSLAETPQIDVHLMPSEAAPGGVGEPGVPPL
TPALANAMFGLTGRRIRSLPIR
>A0A6J5GY22|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinitolerans|TrEMBL
MKRYDDQNGLQAAPASGSRRRFLQTSAALAGGLLLEIGGAGISVAQAATVGDSTAGRFAP
NAWVRIAPDGQIFLVCHKYDSGTGVKNALGMLLADELDADWSQVRIIQPDDPLAAVYIQK
LWGMHATGGSTSVSWQWEPLRRAGATARAMLVAEAAQRWSVDPSTCQTANSEVIHPASGR
RFNYGELATAAATRPAPQQVTLKRPDQFVLIGKPRRSYRVVDKLTGRAQYAIDLQLPGML
TAIVIHPPVVNAKVKSFNAAEVKALPGVRDVFALDIPEVIAHFRPDHAPSRVANGACQPG
VAIVADQFWSAQRARKVLKVEWENSDLANFSSDAAIREMTEHVDDPGKQSNGKGDAKAAF
AQAARVVEAVYTMPYKAHAQMEPLSIVAWVKPDSVDYWGGLQVPSRCAQAAETIAGVPRD
KVRIHLTEAGGSFGAREGLHQVLEVTAISKRVGKPIKLLYSREDDIRGTFYQSASVHKAR
VALDASGHVTGFSLRAVVPSIKEPDDPGFLAKFPVDPSCTESMRADFHYDMPALDLAWVR
HEPGFPIWWWRAVSFVPNVFAIESAVDETAHAVGQDPIAYRSTMLASRPELRAVLERAAT
LAQWTPQTIHDADGTRRGMGVAIYNGYESFIAIVAEVAVKDNTIAVRKVTCVVDCGIAVD
PGSVHQQLAGGIHWGVSTALMNAVHIENGQVRESNFHDYPVLRIHEAPVVQIELMPPTDR
KPGGIGELSNPPVVPAIGNAIFAATGQRLRATPFALA
>A0A6J5FEZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinitolerans|TrEMBL
MISIVVNDTRHTFDDVPEDMPLLWVLRDRLKLTGTKFGCGKGQCGACTVHMEGAAVRSCM
LPAAAADGRRITTIEGLSHDGRHPLQLAWIAEDVPQCGYCQSGQLMQAAAMLAQDGKPDD
ATIVSTMSGNVCRCGTYGRIHRAIKRAASGDPTLNAIVTPMPEHAGKEA
>A0A7W5PVK0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK312|TrEMBL
MTETSRNLVPEDEFPTGAPVNISRRHFLLTSAGAAAGAFVLGFGVPVGRARAQQAASPMP
PGTRVPAFLEIRPDSTIRFMSPFVEGGQGVFTAMAQIVGEELDADPKTFVVENAPTGSDY
LVVHGQMRITGGSMSVRTSYETMRRLGALARNMILQAAAKRLDAPITELTTEPGRVIHAA
SGRSLAYGDVASEALDLPVPAPESVTLRDPSKFRWIGKPVERLDIHDKSTGKAVYAIDCK
VDGMLHAAVQHAPRLGLTIGKIRNEEQLKAMPGVHSVHSLPGAVAVVAERWWNAKRAAEA
AQVDWREPGPDADPAFRYMPADFSTAAFNDRLANEPGNGKEAENVGDIAKAFDGAKTVVS
ATYRSQYLHHAQLEPPSTLARFNPDGSLELWMPNQAPEQFQADIAKLTGLDPSKVIIHSP
ILGGFFGRHFLYPSANPYPQAIQLAKEVGRPVKLIWSREEEFLRDPMRPMAAVRFRGALD
ASGMPVALEAISACEGPTEGVYGHKEDSLDPTALEGLAGKSYAIPNYRIAQIYVKNPTTL
AYWRSVGNSMNDFFYETFLDELADKGGQDPYELRLKLLQKNERLSNLLKAAGDLSGGWKR
GPFTAGDGSRRARGVAMASPFGSHTAAIAEVSIRNGQVVVHDVWEAIDPGSIVNPAIIEA
QVNSATALGMSQVLMEEAVYKNGEPVARNYDLYPILPPDRMARVHVRIVESGAEMGGIGE
PGLPAIPPAVANAVSTLTGKRIRSMPLSNYTFES
>K1L0E4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MSIVKTKLDRRSFLKASALAGGGMMLSFSWLAGCKPSPKEVALGLPDEWFEMNAFIKIGE
NGAVTLFNPNPEFGQNVKTSMPMILAEELDVDWKNVWVEQADFYPERYGRQFTGGSQSIR
QGWQPLRTAGATARAMLVAAAAQSWNVPANEITTESGVLIHQASGKKAGYGEMASLAATL
PVPEEVELKDKKDFKIIGTSKKNVEVNKILTGKPLFTIDYKKEGMLVAMIEHAPAFGMRL
KSFDAAEAKSMPGIKDVFSFKVHQDDYEHNFFDTTTHYEMIAVVGNTTWEVMQAKKKLKA
EWEVAPERSIMQSGFGGNASKVKIPAGLESSEGHRARMEEFSKKPGNILRRDGDPEAAFK
KAAKILERTYNAPYLAHNCMEPVTCYAHVTADQAELYGPIQAPEVISNTLSARLGLPKEK
IQINLARMGGGFGQRAYGHHLVEAAVISKQVGAPIKMVYSREDDMTYGIYRPTYTATYRA
ALDENNKLLALHVKAGGIPETPIAPNRFPAGALDNYLAEGWAIESNITIGAFRAPRSNFI
ASAEQSFLDELAEEMDKDPIDFRLELLERAKTNPVGSNNDYDAERYAGVLKLVKEKSNWG
QSEPGIHRGVSAYFCHNSYVAEVLDLRLEGNKPVVENVVAAVDCGIVINPDAAANMGEGA
IVDGIGNAFFGELPFKDGVPQKNNFHQYRMIRMAEAPKKVEVHFVKNDIDPTGLGEPLFP
PIFAAVSNALYQATGRRLYNQPFMKELESEITRM
>A0A0R2YF08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MELRINQKAYQVDAEADTPLLWVIRDNLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVIGREITTIEAIETDEVGKRVVATWVERQVAQCGYCQSGQVMAATALLKHTPAPTAE
QINAAMINLCRCGTYNAIQSAMQDLAKQESV
>A0A0C4YGE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MNTPRPLCLRVNRTTYQLDAEVDPDTPLLYVLRNDLACNGPKYGCGLGQCGACTVLVDGV
AARSCVIPVKAVAQRAITTLDGLATGGQPDPVQQAFIDEQAAQCGYCLNGMIMTAKALLA
ENPDPSEAQIREALRFNLCRCGTHVEILRAVQRAAVLLRQAAGQDGAA
>A0A3G7UMM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MNTPIKLPQGLLDLASGEPINLSRRRFLTSTAVGALVIGFGLPLGSARVQAATSAAERGT
QVPAFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVESAPPGEAYVVM
ENGLRITGGSMSVRMSYPTMRRLGALARAMLLQAAAEQLGVPVAQLTTQPGRVVHTASGR
SLGYGELAGRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYCIDLKVDG
MLHAAVQHAPRLGMSVGSLRNQAEVQAMQGVHSVHVLPGAVAVVAERWWHAKRAVEAIQV
DWQEAPADSTVRVMPADFSSDKHRDFLAAQQGPARDDENEGDVAGALAGAKTQVQATYHN
QYLNHAQLEPPSALARYNPDGTLEVWLPNQAPDMFRDDIAKRTGLAADKITLHSPLLGGF
FGRHFLYESANPYPQAIELAKAVGRPIKLIWTREEEFLRDVLRPVAVVKFRAGLDANGLP
VAIEAVSATEGPTEALAGKQGEKIDPTAMEGLSGKAYAIPNKRIAQIYVKGPVMLGYWRS
VGNSLNDFFYEAFLDELADKGGQDPFDLRLHLLRDNPRLTTLLQAVGELSGGWKRGPFTA
EDGSRRARGVAMASPFGSHAAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIIEAQVHGA
VALGLSQTLVEEAVYVDGKPRARNYDLYPVLPPARMARVHVRIVESGEKMGGIGEPPLPA
VAPAVANAVAQLTGQRIRSLPLSRYTFS
>A0A2S2DUP6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aquirufa nivalisilvae|TrEMBL
MSKYSIKLNGKKHQVDVASDTPLLWVIRDEIGMTGTKFGCGMGLCGACTVLLNGNPIRSC
STPISSIKPDDKLLSIEGLSANTNHPVQLAWIKEQVPQCGYCQSGQILAVAALLDSNPNP
SDQDIDTALAGNICRCGTYQDMRKAIHAAAKTIKATPKTKSK
>I2GH62|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrisoma limi BUZ 3|TrEMBL
MSLFKLKINGRDYQADVDPDTPLLWVLRDNFGLVGTKYGCGIAQCGACTVHLNGEAVRSC
VMPVSAIGTGKVTTIEGLSKDGTHPVQQAWNEVDVPQCGYCQAGQIMTAAALLKRTPKPT
MEQIDATMTGNLCRCGTYHRIREAVKVASTKGVK
>A0A0A0HLT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus DSM 17069|TrEMBL
MLLTVNGTSHDVDLPSDMPLLWVLRDGLNVTSVKYGCGIAQCGACTVHIGGDAVRSCQVA
LGDVWDDVTTIEGLGTPDSLHVIQAAWIEHQVAQCGYCQSGQIMQAADLLSRNTKPTDDD
IHAAMSGNLCRCGTYPRIRAAVHAAARAMREA
>A0A0A0HLV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus DSM 17069|TrEMBL
MATRLTVNGTPVTLDVNPDMPLLWALRDHLKLTGTKFGCGIAQCGACTVMLDGVPTRSCV
TPVAAVEDAEVTTIEGIQGDAAHAVQKAWADLNVAQCGYCQSGQVMVATELLQNIPKPSD
EEIDAAMGGNICRCATYARIRKGVRAASDALEA
>M4UDE1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum FQY_4|TrEMBL
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VAAVAGRRITTIEGLAEAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA
>A0A3B0RLE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MYQVTVNGKKHQVDVDGDTPLLWVIRDELNLTGTKFGCGVSACGACTVMVDGQPQRSCQM
PVKDAVKSSITTIEAATGKIAHAVQTAWREKDVVQCGYCQSGQIMQAIGLLQENKTPTDQ
DIDAYMSGNACRCATYHRIRAAIHTAAQKLEV
>A0A160TU56|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MEFVVNNKAVTTSAAERTPLLYVLRNELGLRAAKYGCGTGHCGACTVLVDGRPENSCEFE
VSLVEGCRVTTLEGLPNTDLHPVQQAFIEEQAAQCGYCTAGLIMRLVSLLETTPCPVVPE
VRSALDRHLCRCGSHSRVLKVIDRLFSEELVGTTTPS
>A0A3B0TD23|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MKLAINGGSVVVPEKHRDATLLDFLRDFAGLTGTKFGCGIGSCGACTVHIDGLATRSCQI
SVAEVADSEITTIEGLAQTTAGQALHPVQQAWIEEGVPQCGYCQPGQIMTAAAFLRRNPD
PTEAEIRTEMSGNLCRCGTYGRIRRAVARAAAQAARES
>A0A160VD81|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MAEKVFINRRDFIKTISTAGAGLTLGFYLPFKDRLRAEVSRSTVDFVPNIWVSVNPNSQV
TLTVSESEMGQGVWTSLPMIIAEEMELDWTKVKVVQAPVDENYFGRFDMGTGGSSSIRTS
WDKMRKAGAVAKDMLHEAATIEWSVSKADCFAENGFIVHRLTGEKISYGDLAHKASMLDV
PKSVQLKNPDTFRIIGTDILRTDAPLKVNGTAQYAMDVNLPDMMYASVERCPYFGGKLKT
VDDRDSKKVKGVLDIIEIENGFAVVGTSTWAALQGRKKLKITWDKGSNKYPDSKSISEFF
KKRSRKRGAKGRNEGNVKKALKDADRVIEAAYEVPFQAHATMEPMNCVVDYQSDQCQVWA
PTQSPKDAKKRVREMTGLSDEKVIIHVPFLGGGFGRRAFNDFIEEGVEVSMKLKKPVKLI
WTREDDMQHDYYRPASRHVLKAGLMDNGETIAWFHSVVAPSIFFGQMFKYPVPFKDKLDV
VALAGAKEVAYGIPNIRVEYTSANTDIPVGWWRSVYDSQNAYANECFIDELANSLKIDPV
DYRLRLLKQSPRHTAVLKQAAQESDWGKPLKNNHYQGVSCHASFGTYVAQIAEVSVNNEG
SVHVHRVVCAVDCGQAVSPITIKAQMEGSIVYGLSATLNGEITIENGAVKQSNFHDFQVL
RMDQMPTIDVHIIKSSEPPSGIGEPGLPPIAPAVANAVFSATGKRIRKLPIKAEDFLA
>A0A143PL64|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteitalea pratensis|TrEMBL
MTPAMSGEVTRRAFLRVSALAGGGVMLALHAEELFAAQQPQAPGAPPPPPLAPASFVRIA
ADGRVTIMAKNPEIGQGIKTMLPMLIAEELDVDWAQVTIEQASLDQAAYGPQRAGGSSAT
PTNWEPLRRVGAAGRQMFIAAAAARWSVPASECTTAHGAVRHAATNRTLGYGALASALTT
LPVPDLQSVPVKAASEYRIIGTPIGGVDNPLIVTGKPLFSIDFTLPGMLWAAYEKCPVFA
GKVKSADLDEIRALPGVRKAFVIEGTKEMLGLHGGVAIVADHWWAAHSARGKLKVEWDEG
PTAEVSSAWIATRAKELAAAPPVFTIRADGDADAALSSAAKVVEGDYTYPFIGHAPLEPQ
NCAAQFTGGKLEIWAPSQTPETGRGMVSTLLGIPLDQIKVHILRVGGGFGRRLTNDYMLE
AAWIAREVGGAPVKVLWTREDDVQHDHYRPGGFHHFKAGLDASGRLAAWRNHFVSFGEGK
QFAPTAGITPEEFPAGYVANFGFHASLIPVGIPMYALRAPGSNAFCFAFQSFLDEVAHAA
GADPVAFRLALLDAALASQDAPNAPKLQFNPKRMRDVVARVAETSGWARQQKTPGVGMGV
AFQFSHRGYFAEVARVRVTGDTKVRVEKVWVVGDVGRHVINPSTAINQVQGGVIEGMSHA
MSTEITFERGRTMQSNFHDYELVRHRETVPEVDVDFVKSDNAPTGIGEPALPPAVPAICN
ALFAATGKRYRALPLARHGLSWA
>A0A8B6MCF3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylocella tundrae|TrEMBL
MMIKTTVNGEARTFDGDPDTPLLWYLRDELGLTGTKFGCGQALCGACTIHLGGTATRACA
TPISSADGQQITTIEGLSPDGDHPVQIAWRELNVAQCGYCQAGQIMQAASLLKESPKPTD
EEIDNGMSGNLCRCGTYPRIRAAIKQAANATAHSGKGGL
>G2ZWS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|blood disease bacterium R229|TrEMBL
MNADATAPHRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQAGEVALNGWIKV
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVSVESSPIERIYGNLVVMGDSAL
PLHPDDADKAWARALHWIMAKSAREIGLIITGGSSSVADAWQPVREAAATARATLVEAAA
REWNVPAAQVSVRDGRLIGPGGQQAGFGAVAQRARDIAPPASVTLKPASQYRLVGKPAPR
NDVAGKTDGSARFAIDARPPGLLYAAVAMCPVFGGKLKAFDAKAAQGMPGVRHVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLAPVWDNGPHATLDSAGIRRQINAALDGDRGGFTYRS
TGDGLKAFDNVSGATVVEAEYSVPYLAHAAMEPVNCTAQVTQDRVQLWAPTQVATLAQLV
AARAAGMRRDQVHIDIPLIGGGFGRRLESDFIGQAVTIAAQTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIENGKVTAIASRSAGQSILAGELDRLFGAPSLGVDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEAAAAGLDPLAMRRDLLKAHPR
ERTVLDTVARAAGWGQPLAPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRVV
CAVDCGTVINPGIVAQQVESAIIFGLGAALHGQIQVKDGQVVQSNYPDYPVLRMAETPII
ETHLVPSTAQPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>Q88GU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)|TrEMBL
MELRINQKTYQVEADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIEADPVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPKPSDA
QIDAAMVNLCRCGTYNAIHAAVHDLAQGEQA
>A0A839YE67|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK580|TrEMBL
MTRLTVNNEAVEYRLSPETPLLWALRDASNLTGAKYGCGTGSCGACTVDVDGRAVRSCQL
TLAAAEGTFVTTIEGLSRDRTHPVQLALLAENVSQCGFCMPGIVMAAAVLLRRDPMPSDD
AIAAAITNICRCGIYPRLTAAIQRAGRAIRGEERLPTGARPGIEPAGAARQVPALDPRQR
>A0A221JXF3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter pseudonitzschiae|TrEMBL
MGRVKTIARRSFLVGSVAIVSGVAFGYYMYRKPGPNPLLDDLQEGEAALTPYVKIDASGI
TLITPRADSGQGAYSVQAMMIAEELDVDMDQVRVDPGVPSPAYYNTALAAESAPFRPTDR
STMANTTRGVMDAVMKFTGMQMTGGSTTVPDGYEKLRMAGAVARETLKVAAGRRTGQDPK
KMTTERAHVILPDGTRIAYTDLATEAAQIEPVDHLALRHPSRWRIMGTPQQRLDIVAKST
GTQRYCIDFEPQGAVHATVRTNPRKGGAMLGFDATAAEKMRGVKQVLPITGGVAVVADNT
WRAFAAVQAIDIDWDDAPYPLEMDSHWQALSDSFNDDRLDSRKRDDGDVAAAAHEATDAE
VVEAEYRAPYLAHAPLEPSNATVLVGDDRVDVWTGTQVPRFVQANVAKLTGIDADNVHVH
VQMMGGSFGQRLEDDVERQATEIAMQMKGTPVKLTYRREEDMVHDHPRQIAMARGRGVVR
DGQVHAFDLGIAMPSVMSSQMGRQGWTVPGPDLQIVAGAWEQPLKIPNYRVSGYRAPELA
PVSSWRSVGASTNGFFHDVFLDELIHAAGADPVEERLRLMWHEPSRKVLEAVAEMSNWAT
MPGAGRGRGVAFCTSFGVPVAEVIDVTATPDGTRIDNVWVAAEVGRVIDPVNFENLVQGG
VIFALGHAINCEITYADGMAEQDNYYAFEGLRMRQAPKIEVRGLENDIHVRGMGEPMVPP
AAAALSNAIFAATGQRIREMPMNRHIDFV
>A0A508SVD6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MIELTVNGIKHRVDVVPEMPLLWVLRDELGITSPKYGCGIAQCGACTVQINGAAVRSCQA
RIGDLAGKSVVTIDGLDNREQHPVLQAWIEHQVPQCGYCQTGQIMQAVSLLELIPKPTDE
QINEVMSGNLCRCGTYPRIRAAIHAAAAKMAEK
>B8KKS9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|gamma proteobacterium NOR5-3|TrEMBL
MLKLMVNGKSMEADADPSTPLLWVLRDHLGLTGTKYGCGIAQCGACTVHIDGKAIRACVY
PASAAAGKSITTIEGLSEDASHPVQQAWVEIDTPQCGYCQPGMIMAASALLSENPNPTDA
DINQKMTNICRCGTLPRVREGIHRAAAIAAGDEGAQS
>A0A7U3ZHE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MEITFDINGKTAKADVDPDMPLLWVVRDELNLKATKFGCGAAMCGACTLHIDGEAYRSCS
IPVSFAAGKEVTTLEGLSESEDKLHPVQQAWMEENVPQCGYCQPGFMMAAAHFLAKNPHP
TDEDIKSNITNICRCGTQPRILKAIKRAAQIKQTVTI
>A0A839XZ21|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella sediminis|TrEMBL
MPEQTFIVNGERVTVEVEDNVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
AVQVGDLSADDEVTTIEGLPAQASEGARGQHGLHPMQEAWLERDVVQCGYCQPGQIMAAV
ALVRKVRDEGRTITDADLDGIRNICRCGTYTRIREAIRDGETRM
>A0A0U5F6Z9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ghanensis|TrEMBL
MTSHTVPNASRRQLLGAGGALLLATLWPVPRGRAQSSPRPEQGMLVENAPGAFAPNAYIR
ITADNRITLILPNVEMGQGIYTSSVMLIAEELGIDLPQVDIEAAPPGAGAEITGGSTSVM
TEWLPLRQAGAAARSMLVQAAATRWHAAPEDCITRSTTIIHVPTKRTLPFGAVVADAAAL
PVPQKPALKDPASYTLLGRSQHRIDSAIKVEGRAIFGMDVQIPGQKIGTVAACPVEGGTL
SGMNKQAALAVRGVLAVLVNEPGNTVCVVAEHYWAARKGLRALKPQWHYGPNAHVTTQTI
YDQLHDGLTGPAIVANTKGDAPAILAHAPTTHTAIYQQPLLAHAPMEPINCTAHVRTDGC
DVWTGTQIADRARDTAAELTGLPKEKITVHCQYIGGGFGRRLEHEYVTQCIQFARQVPYP
LKIIWSREEDLTRDRYRPAYVDQMTAALDDKGFITALTHRIVGPAVVARWDPPELTKDGY
DEDLSVATVITPYTYPAYRLEFARREAPGIVTAWWRGVGGTRGLFVVEGFIDELAHRAGM
DPVAYRRAMLAENPRALAVLDRAAHAAGWDTPIPQGRARGVAVQFAFGSYMATIAEVEMP
SPDTVIIHRVTAVVDCGRVLNPDQVVSQIEGGLIFGFSAALYNEITLEGGRVQQNNFNTW
RVMRMNEAPRQINVLLMPSTEDPGGIGEVGTAAAAPVLANAMSAAQGRRYRTLPLLSPRN
GADGKEQG
>A0A0U5F7Y7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ghanensis|TrEMBL
MVNGLFDDAPLMQQGPVNLSRRRFMLTSAGATTGAFVLGFGLPARQARAQAAQGPKYRGT
RVPAFLEIRPDNTVRLQSPFIEGGQGTFTAMAQIVGEELDAAPSTFLVENAPGRR
>A0A6S7FK90|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter insolitus|TrEMBL
MTQIQINGQAKNVDVPGETPLLWTLRDELGMTGTKFGCGMALCGACTVHMDGAPIRSCVT
PLSAVAGHHITTIEGMEADAVGQAVQQAWIEQNVAQCGYCQAGQIMTAVSLLKAAPQPTD
QDIEDAMSGNICRCGTYPRIRAAIQQAAKHLAQGGKQ
>A0A375HUG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus neocaledonicus|TrEMBL
MNLHVNNQAVSVECDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHLDGAAVRSCVLP
VAAVDGKRITTIEGLGSAPGKRHPLQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
SDIDAAITNLCRCGTYPRVRTAIKRAAKALRERRA
>S7V8X7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cyclobacterium qasimii M12-11B|TrEMBL
MKLRVNNKEYSVEVANNPSLLEVLRDKLDLTGTKYGCGEGACGACKVLVNGIPTPSCITP
VTSVSGKKVITIEGLAENGELHPVQKVFLEEDVFQCSYCAPGMVITAAALLKKQPDASTQ
DLIDGLNGNICRCCTYPAIINALKKIIQKEGEQ
>A0A7W5J7Z2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoxanthomonas sp. OG2|TrEMBL
MDAKPADSVASSSRRQFLKAGAVLGGGLVIGFIVPAAGRFALAQNAAAAPATVAPFAPNA
FLRIAADDSITVLLSHSEMGQGIWTTLPMLIAEELDADWTKMKVEHAPAAPAYAHTAFGM
QMTGGSTSTWSEFDRYRMAGATARALLLQAAAARLGVPVAELKTENGVVVHGDQRLRYGE
LADAAGQLKAPDPKTLTLKDPKDWKLIGKGAKRLDTPEKITGRAIFGMDVQFDGLLTAVV
ARAPVFGGTVKSFDATAAKAVPGVRNVVQVPSGVAVIADHYWAALQGRNALKVEWDRGPH
ADLDSARLREQFATQARTAGAVAVQAGDAAAAMAQAAKVVEVEYSVPYLAHAPMEPLNCT
VKIDAEGCDIWTGTQFQTVDQQVAARITGLKPEQIRIHTTFLGGGFGRRATPVSDFVSEA
VEVAKAAKAPVKTVWPREDDVRGGYYRPAYVQRAKVGLAADGTPVAWQQVMVGQSITAGT
PFEPFTVKNGIDATSVEGVADSPYVLGTPAHRVDLHSPKTGIPVLWWRSVGHSYNGFVME
SLVDELAHAAGQDPLEYRRRLLKDHPRHLAALNLAAEKFGWSKPAAKGRGHGIAVHESFG
SYVAHAAEVSVDNGVIKVHRVVCAIDCGLAVNPDNVKAQLESGLAFGLGAALHGRITFKN
GEVEQSNYHDYPVLRLPEMPVVEVHIVPSTDKMGGVGEPGTPPIAPAVANAVFALTGQRL
RDLPFTLAPAAKPA
>A0A839P0E3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium sp. R2-1|TrEMBL
MVSLTINGHQHQVDAEPDTPLLFVLRDALGLTGTKYGCGIGQCGACTVLLDGQATRSCQV
PVESIGAQGVTTIEAIEADPVGARVVAAWVGIEVPQCGYCQSGQVMAATGLLKETPKPSE
DEIAAAMTNLCRCGTYNAIAVAVRQAAA
>A0A2U3K9U5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfopaludibacter sp. SbA4|TrEMBL
MPAVRFTLNGKPQTVDVVPNMPLLWVLRDTLGLTGTKFGCGMALCGACTVHVNGQPMRSC
ATPISSIAGKTVTTIEGLSPDSTNPVQLAWIEHDVPQCGYCQSGQIMTAVALLAKTSRPT
DADIDEALRNNICRCGTYDEIRRAIVRAAEIQRAQGGAK
>A0A5E6U9Y5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIEFTVNGERHELVEPSPSMPLLWVLRDHLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPVAAVAGHRITTIEGLSATEQHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
DSIRNAMSGNLCRCGTYGRINKAIKRAAAAPKEA
>A0A5E7NJB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGHKFAYAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMPGFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFEVAPSAIRTESGVVIAGDKRATYGDLADAAGQLPV
PDPKSITFKEAKDWKIIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGASV
KSFEGAEALAVPGVHKVLQVPTGVAVIAEHYWAAKLGRDALKVDWDLGPHADLSSEKLLA
SFRKLAATQGTSASQAGDAKGSFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAEKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMP
VKTVWSREDDIRGGYYRSMFLHQAKIGLGADGLPSSWQHVLVGQSIMAGTMLEKTMVKNG
VDATSVEGVSDSPYVKGLANHQVDLHSPQTGINVLWLRSVGHSHTAFVMESLIDEMATAA
GKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHSLGVAVHESFGSYVAQVAEVS
QDNLKIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLRDGAVVQSNYHD
YQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>A0A5E7IMJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSALLSGGLMVAFVVPGANRFARAAENQNKTFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGLPAFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFDVAPSTIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKTITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGATV
KSFEGAAALAIPGVHKVVQVPSGVAVVAEHFWAAKLGRDALKVDWDLGPLAGMSSEKLLE
SFRKLAATPGTSATQAGDAKANFGKAAKKIEVEYSVPYLAHAPMEPLNCTVKISAGKCEI
WTGTQFQTLDQMVASKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAADLP
VKTVWAREDDIRGGYYRSMYLHKAQVGLGADGLPMSWQHVLVGQSIMAGTMLEAAMVKNG
IDATSVEGVADSPYIKDLPHHQVELHSPQTGINVLWLRSVGHTHTGFVMESLIDELATAA
GKDPVEYRRTLLKAHPRHLGVLNLAVEKANWGAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTVKDGGVVQSNYHD
YQVLRLNEMPVVEVHIVPSSEKPGGIGEPGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>A0A5E7S4X2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQGQVELSRRRFLQHSATVASGLAIAFYLPAGAAATGPGAPASSAEFEPNAWVRVLPDG
TVKLVVHKHDSGTGTHTALAACVAEELDVNPMTVQVISPENPFFETYIHPVWKVFSTGGS
TSVSLEYDRLRLAGATARTLLMTAAARQWKVSPDSCSTEEGRVVHAASKRSVGYGELVSV
AAHLPAPAGVTLKDPTQFKYIGKLRHKRDAQAKVCGRFTYSIDVVLPQMLVAVIERAPVV
GAKVLAVDAAATLQVPGVRQVIAVPGRPDILGGNLEGVAVLADNYWAAHQGREQLKVQWS
DSPLAGFDSDELAKAQAAAIDDPHAQRVTAMAAGDVNAQWPHAAKRLEADYRMPYKVQNP
LEPICITAQVKDNAITYWGGVQVPSSALEAAQTVCRIARDKVIINELVSGGSFGAREAKY
WLFEVAYLAQQARVPVKLMNSREDEMRALFMHPATLHRAKGALDAQGRLTALQLNAVSPA
SPEQWEPGYFERPDKMDYSTTEAITAWDFAYRPANLDLVWVRHESQVPSGWYRSVSFIPN
VFAVESFMDELAHGAGQDPLAFRLANMQERPRHVAVLKSAAERAGWGQPLPDGTALGIAT
NQGYSSFIAVVARVAKKDGVICVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHALFDR
LDIKAGRVVQSNFHDYRVARMSDMPEVDILLVEGEPGKPGGVGELGSPPVAPAIANALFN
LTGVRQRSTPLALG
>A0A5E7HCK7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MMTFTVNGERRELDEASPSMPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPLAAVAGHSITTIEGLSPTQSHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGATLTD
DSIRNAMSGNICRCGTYGRINKAIKRAATAPKEA
>A0A379JBM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDATEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVKGQNVSTIDNLHNDPIGQVVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
AQIEEAMVGNICRCGTYNRIKTAIRQAATQLQGGKA
>A0A448BMB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MPTSLVLNGKNVTLDVDPNMPLLWAIRESAGLHGTKFGCGMAQCGACTVQLDGTAVRSCV
LPVSAVAGKRVTTIEGIQSKPGKAVQDAWVKLQVPQCGYCQSGQIMSATALLEQNASPSD
ADIDAAMNGNICRCAAYVRIRAAIHEAADTLKA
>A0A5E7M2W2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSVLTINGREYTVDVDPSTPILWTLRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGRKITTIEAATNGSDPVGTAVHEAWVKHDVAQCGYCQSGQIMSATAFLKVQPKG
KQPTAAEIDSAMAGNICRCGTYARIRAAVADAAKVLA
>A0A5E7WI02|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNNLNPLSRRGFLKGSAVLGGGLVVAFVIPGGHRFAMGAENQGNVFAPNAFLRIGNDNSV
TMLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAAEYGLAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIRTESGVVIAGDQRATYGELADDAGKL
PVPDPASIKLKESKDWKIIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVDWDLGPNTGLDSQTL
LESFRKLAATPGASASQAGDVAAGLGKALKTIDVEYSVPYLAHAPMEPLNCTVKITKDKC
EIWTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVEVAKAAG
APVKTVWSREDDIRGGYYRSAFLHQARIGLDAGGLPIAWKHVMVGQSIMAGTSFEATMVK
NGIDKTSVEGVADSPYLEGLANHQVDLHSPQTGIRVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKNGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A7W8D7F7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chiayiivirga flava|TrEMBL
MTKHRKTLPLHTVQLVNESRRGFMKAGAGLALGIYLSPLLGDAADVLAQAPAAPPMPKVP
PSAFLRIAADGGVTVISKHLEMGQGTFTGLATLIAEELDADWSRVSVEGAPADVSKYGNL
AFGGAVQGTGGSTAMAGAWQQMRMAGAAARAMLVAAAAEQWQVPAKDITVSSGTIAHKAS
NRSAHFGEFAEAAAKLPVPENPTLKTPDQYVLIGKDSVRRRDSAAKVNGSAQFTQDVHLP
GMLVAVIARAPRYGAKVASFDDSAARAIPGVVAAFAVPGKDKTYEDGVAVLAKDTWTALK
ARKALKIEWDESRAWRGSSDSLLADYRKLAATPGAVAVSRGNAAAAIEGAAKTVDAEYSV
PYLAHASMEPLNCVVQLTANGGCEIWNGEQFHTPDQGAVAAQLGATPDKVLIHQLYAGGS
FGRRANPKSEYILQAVQVAQLAAKAGHNVPVKTVWSREDDTAGGYYRPLALHVARAGLDA
QGNIVGWTHRIVGQSIAKGSPFEAMMIKDGVDESLIEGISDLPYDAAALHVDLHIADNPV
TTQWWRSVGHTHTGFAAEAFVDELAAAAGKDPYVFRRERLDKHPRERGVLDLVAQKAGWD
KPLAKGKDGERRGRGIAVHKSFGSYVAQVAEVTVHKDGSVKVDRVVCAVDCGIAINPDVI
RAQMEGGIGYGLSAALHGAITFKDGLVQQSNFHDYKQLRIHEMPKIDVFIVPSEEKPTGV
GEPGTAVIAPAFVNAIANATGTRVRQLPLDPASLRA
>A0A0D0QCK9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Wenxinia marina DSM 24838|TrEMBL
MTERFNLSRRGFLISAAASTGGLAIGFPLGASAQQLNELASPELNAWVVVQPDDTVIVRV
AKIEMGQGTLTGLVQLVAEELDADWDKVTWSYPTPGENVARERVWGSFGTFGSQGIRTSQ
EMVRTGGAAAKAMLIQAAANRWGVDASEVTASKGVLTGPGGDTLTYGAVAEEAAGLEVPA
EVTLKDPSEWTIAGQSLLRLDTADKTDGSRIFSIDYTMDGMLNAAIKIAPVQGATVAGID
AAAVEGMPGVQRVLQVDETTVAVVADTWWRARTAIEALPIEWNIPEDVGSFGMEDLEAML
TEGLTADDAFVGNEAGDVEAAFADAAQVVEADYSYPWQHHVTMEPMNATALVTDDSCTVW
TSTQNAESDLAAASETSGLEIPQCEIHRMNLGGGFGRRGASSTDYTTIAVKIAMEMKGTP
VKVIWSREEDMLHGTYHPATKARFRGALDEDGNLTGMHMRISGQSIFAGLMPFALEDGMD
PLQFQGLQAESTEGAFGYDVPNLLIDHAMRNPPLRPGFWRGVNNNQNSFYLESFVDELAH
AAGRDPLEFRRGMMANHPKHLAVLNAVAEGIGWEAGAPEGRAYGICQHMGYGSYVAAAAE
VSVDGDRVTIHRIVAATDPGHVVNPQQVEAQIEGSFAMGLSASMMSQITMENGRVQEENF
DTYPIISMWEMPEVEKILVPSGGFWGGVGEPTIFVATPAVLNAVFALTGTRVRELPIYKS
GLSLG
>A0A1W6KB81|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter salarius|TrEMBL
MSMNRRDFLKVTAGSSGGLVLSLSLPGCAGIQNGYDEQDGSWKPDAWLELTTDDQVYFTL
ARVEMGQGTYTGLTTLIAEELGVAPASIKPRFAPAAPEYRNPLYNLQLTGGSTSLATSWQ
PLRVAGASARMMLVAAAANVWEVSPAECRAVEGRVIHPNGRDSLAYGRLVELAAKQPVPE
APSLKPREEWKYIGKERGRLDAEAKSTGAPIYGIDVELEGMVYAVVSRPARYGARVKSYD
DTAARRLPGVLDVFEIERGVAVVADKYWRARKAQDALTIEWDNDGALDVSSELVFSSYHK
AADEDPGESERSEGDYDDAQQGAERVVEASYEQPYLAHATLEPMNATAWYRDGAIEVWAP
TQAPDLGRIAAARVTDLSPDEVTIHTTFLGGGFGRRLTNDYIEEAASVAYRVRKPVKLIW
SREEDTRHDVYRPAMLHRMRASVSGDNVTGWHHQIVGPQILDWYVRNAAPAQYPWAPKFL
YGTLGRVGLLAEGVATPKDHSAIEGAIEYPYRVPNIDIRHTHTDPGVPVSWWRSVGFSHN
GFAVETFMDELAHEQGQDPYRFRRSLIDHEPRHLGVLDRVAQLAQWDSAAPEGRARGVAL
FRSFGTYVAQVVEASVEFGEIRVHRVYCAVDCGQVVNPDIVRDQIEGGIIFGLTAALYGN
ITLEGGQVQQSNFHDYPLMRHDQRPEVVVDIIDSDESPTGVGEPGVPPVIPALGNALFAL
SGKRQRSLPLKATV
>A0A840FK10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax guangxiensis|TrEMBL
MPVQSFKVNGQNVDVEAPDDMALLWVLRDKLGITGPKYGCGINVCKACTCHVDGKAVTTC
STRVSDVRGRQVTTIEGLANGNTLHPVQQAWLNLDVPQCGFCQPGQIMAAVDLLRRTRNP
TDADIDAIENVCRCGTYGRIREAIKAAAAAMG
>K6ZPG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Glaciecola pallidula DSM 14239 = ACAM 615|TrEMBL
MIELFQQAANNASTKQTKSVSRRDFLKLTGMTTSGFVLGSMLPVSLPAWAHGNASHAGDN
TLNLFVTIETNGRVNIICHRSEMGQGIRTSIPQIVADELCVAWKDVHVVQGLANEAYGSQ
NTDGSRSIRNFYAKMREMGATARTILEQAAAEQWAVPITDVYADDSFVINRNTKQKISFA
ALAEPASKIKPPAPDALTYKSKKDFKYIGKPIQILDLPDMVTGNTIFGQDVKLEGMLYAS
IERNPVVGSKVESFDKAAAMKTGGVVDVYKMPEQPTPVVFNPANGVAVIATNTWAASQGR
KALNIKWGDSPHKDHDSAEYLAQLNQRIVGKGKTIRQGGDAYAAMQQSQQTVAATYTVPY
LVHAPMEPPAATAVFKDGKCEVWACTQTPQSTQQNVAGALGIAKENVTVNVTLLGGAFGR
KSKPDFSIEAALLAKYTGKPVKVVWSREDDIRQGYYHAISSQHFEAGLTADNTVNAWIQR
TAFPSISSTFDGTTDEPSDGELSLGFGDVPFHVENLSCETHKAPAHIRIGWVRSVCNIQH
AFSQGSFVDELAHAAKVPTHKMWHQLLGNDRLVNPKDQGFEYGNYGETLERFPIDTKRLK
DVLDDVVAKSGADQPTDDGEAWGISAHRSFVSYVAVATKVRVKDNKVTVLEMHSSIDAGT
VVNPDRVRSQQEGSMIFGLSLAMMGEITVKEGAVEQSNYNDYQVLRMSQSPLITTYIVES
DAIPGGVGEPGTPPVAPSLTNAIFHACGKRIRDLPVNKHFTV
>A0A0M7MDD0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter aegrifaciens|TrEMBL
MGSTVYPSSAPQPIRLMVNGCAHDVPAAPGTALLHVLRNDLELNGPKYGCGLGECGACTV
LIDGVAGRSCVIPVKAALGRAITTLEGLGTRQRPGPTQQAFIECQAAQCGYCLNGMIMTV
EALLRRNPCPTEAALRSELHHNLCRCGTHVEIMQAAVRAVQLRTAGVADDPAP
>A0A7Y9RLB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. IAR9|TrEMBL
MNKHVSPRLNRRAFVIGTAAVGAGLAIGLDLPFGGPAVVRAADGSPEIGAWVVVRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELECDWTKVTTEYPTPGQSVARKRVWGDFSTGGSRGI
RSSQDYVRKGGATARVMLIQAAADAWKVPASECAAANSVITHTPSGRTTTYGKVAEAAAK
LSPPAEVKLKDPKDWKLIGKGVKRLDTVDKTTGAMIYGADIKLPGMLNAAIKDCPVFGGK
LKSFDEAKIASMKGVKKVVKVGDTAVAVVADTWWHAKTALEALPIVWDEGDNAKVSSETI
AKWLAEGLNNDQPAYVGNKNGDAKAAIAGAAKKVEAVYSYPYQNHATMEPMNATALYTAD
KCEVWCGTQNGEAAFAAVLEASGLPADKCDVHKVMLGGGFGRRGQTDYVRQAVMIAKEMP
GTPVKLLWSREEDMAHGRYHPITQCKMTGAFDANNNLVALHYRLSGQSILFSLRPEALQN
GMDPAAFQGVAQSGEAAFGYSVPNLLVEHAMRNPHVPPGFWRGVNVNHNAIYMECFMDEL
AQAAGQDPLEFRRKLMGNHPKHLAVLNAVAEKIGWTTPAPQGVYRGIAQVMGYGSYVAGA
AEISVTDGSKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGKIEQ
TNFDTYNSMRINEMPKVESVMVPSGGFWGGVGEPTIGVAAPAVLNAYFAATGKRIRSVPL
RDQNITFA
>W6W9Y9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. (strain CF080)|TrEMBL
MVTFTLNGQERTFDGDPDTPLLWVIRDFEKLTGTKYGCGVAQCGACTVHLDGMPRRSCVT
TIATIEGSEVVTIEGVSGTEADAVKTAWTGLDVPQCGYCQSGQIMSAVALLQMVPKPTDA
DIDGAMAGNICRCATYHRIRAAIHNAASAMEG
>A0A840N0R2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Afipia massiliensis|TrEMBL
MNKHLKVNSSTDLSRRSFIVGTSAAGLALGFASVPGSSALAAPASFDPSVWYSIAPDGLV
TVTCGKADMGQHIASTMAQLVAEELGANWKDMRVKLASNDPKYNDPVLGAQITGGSWSTM
MNFDAMSRAGAAGRTALTEAAAAMMGVPAGELVVRDSRISHPKSKKSLTFAEIVKGGKAT
KTFTADELKALKLKTPDQYTLVGQSIPQLDIPSKTNGTAKYGIDTFLPGMVYGKIVMPPV
RYGATVKSVDDSAAKKVPGFIKAVTLEDKTGTTTGWVVAVANTYANAKKAADALKVTYDN
GPNAKVSSESLLAEAKRLQADNASGLFFVKNGDTAEALGKASKVMEAEYTTNINIHAPME
PMNATAEQKGDIWHLYSGNQFATRSGAIAAGALGIDPKFIVMHQAWLGGGFGRRLDGDMM
IPAVLAAKAVGKPVKVIYSREDDTIMDFSRPLTFQKIKAGLDDSGKLVAFNHDVVSAWPT
KRWGIPAFLSPDVEKKGALDAFTVNGADFFYTVPNHNVRAIINEMAQSATPSGQLRSVAP
GWTFWAVESMLDELAVASGKDPAQFRIDLLDGAGANAGGAQRLRNTLLAAMGLAGYGTKK
LPKGEGMGVACVSSQERATASWTACVAHVAVNDSGEVKVKKLTVATDVGTQVNPDGIRAQ
VEGAALWGMSLALFEKATMKDGAIEQTNFDTYTPMRMSQVPEVALAIIANGEPATGVGEP
AVTVVAPALANAIYNAVGARVRSLPITADAVKAGMKKA
>A0A379FNE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Providencia rettgeri|TrEMBL
MQLNINGRWIELSNISPSTPLLYVLRNDLKLNGPKYGCGLGECGACSVLIDGKVVRSCST
PVSTVENRKITTLEGISDSETLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFKRNPNASE
EEIKKELAFNLCRCGTHVEILKAAKKAKMIIAQGGKA
>A0A840MWF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Afipia massiliensis|TrEMBL
MPTLSINGRNMSVDAAGDTPLLWVIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
ALSEVAGKKITTIEGLSAKGDHPLQKAWILEQVPQCGYCQSGQIMQAASLLAKNTNPTRD
EVVAHMDGNLCRCMTYSRIQKAIMRAAADMRTASNAPADRRAT
>A0A7W4VPE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Microvirga lupini|TrEMBL
MTAALDVSRRSFLVGSAAAAGGLALGFNIPFTREALAQSAPEINAWVMVRPDETVVVRIG
RVEMGQGTLTGLAQLVAEELECDWAKVTTEYPTPGQNVARSRVWGNFQTAGSRGVRDSHD
YMRKGGAAARQMLIQAAANEWGVPAGECTVAKGVITHSPSGRTTSYGKVAEAASKLEAPK
DVQLKDPKDWTIAGKPVKRLDTAEKLNGSQIYSIDVKRPGMLNAAIKACPVFGGKLKSFD
AAQAQGMPGVKKVVAVGDNAVAVVADTWWRAKTALDALPIEWDEGPNAALSSEGIDRMLK
EGLTAEQAFVGNQAGDVKAAIAGAAKKVEAEYGFPYQHHATMEPMNATALWTNEKCEVWT
ATQNAEAALATAVAASGLPIEKCDVYRQNLGGGFGRRATSHDYVRQAVLIAKEMPGTPVK
LIWSREEDMLHGHYHPITQAKMVGALDADGNLTGLHMRISGQSILAGVNPQGLQNGRDPA
TFQGLNPSGTEGVLGYTIPNLLIDHAMRNPPIPPGFWRGVNNNQNALYLECFMDELAQAA
GKDPLEFRRKLLVNHPKHLAVLNAVAEKAGWGTPAPQGVYRGLAQHMGYGSYVAACAEVS
VGDNGVLKIHRIVAATDCGHAVNPQQIAAQIEGSFAYGLTALLYGEITLKDGKVEQENFD
SYQMMRMDEMPAVESIVMPSGDFWGGVGEPTIFVAAPAVLNAIFAATGKRIRSGPLTKAD
LRKA
>A0A7W7EUI4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium taihuense|TrEMBL
MRLTRRGMLVGAGVGGALLIAFPLIPRRYPVPLEAGKDEHVVDAFLKVGRVKGGAAGKAD
CILTVAVPFCEMGQGITTLVAQIVADEAGADWRKVAVEAAPISPAYADPVLSAKWAPLWM
PAFASLGADAEGMLARLHAERGPLMITADGTALAAFEAPLREAGAALRAMMAQAAADKWG
VGWEECETKDSFVTHGPKRLSFAELLDTAVDYDPPAVPVLRAEPPREKPGQFPEGAPPRH
PRLDLPAKVDGSFTFAGDVRLPDMVFAAIAHGPQGASVLSSYDKQAAASVRGLVGVVHAR
RWLAAVATDWHSADKAVRAMEPRFKADGPIADSEKVLVALDKALTKGEPQRLLAEGDPDA
LLAKPSLTARYDVEPAFHAPLETASATARLRHGLLELWIATQAPERARRAAARAAGLSRR
DVIVYPMHAGGSFDARLDVRIAAEVAAICKVIGKPVQLTWSRWQEALAGIPRTPVSAQLD
GALSPDKTRVLGWRARLAVPATAFESGARLLDGWGVTDALDLQDQADPMACEGAMPLYRI
PEKAVEQVPLALRQPTARFRGQAHGYTAFFTESFVDELAHAAGKEPLSFRVGMLEGEPRL
VACLQGAGRLAQWGGGIEASGQGIACHQMELALGGGRVTKGLIAVVATARSEAGVVRVER
LSAYVDIGRIVNIDIARQQIEGGLMFGLAHAVGGASGYAKGRPLAGRLSQLGLPLLADCP
KVDIAFADSNEDPFDPGELGMVAVAPAIANALFSATGVRFRRLPLISEGL
>A0A375EV43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MADLARLSRRGFLRGSLGLMTLAVTSGGLVTVARAADPAPKKFGADSMPGGTVDDPLAFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVAQAEADETRYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPVSEVRAVQHEVLHQPSGRRLGFGELAAD
AARQPVPKGDALRLKPRAGFRYIGKNAVRPVDQETIGLGRAIYGMDLRLPGMVYAVVARP
PVVGGKLRRLDSRKALALPGVLKVVEIPAFQGAPAFQPLGGVAVVARNTWAAMQGRAALE
IEWDDGPNGSYDSTAYRRTLEAASRAPGKAVRNQGDAQRAWDQAPAAERLAADYYVPHLA
HASMEPPVATVRIRGGSAEVWTSIQNPVAAQTAVARRLELKPGNVRVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPDGTPVKLVWTRDDDIHHDYLHTVSAERLEAVIDRQGQVKSWLHR
SAAPTIASLFTEGAKGQQMFESAMSAINMPYRIDNVRVETAEVPAHARIGWFRSVANIPH
AFAAQCFIAELAHRAGKDHRQFALDLIGPARKIDPGTLADNWNYTESPERYPYDTGRLRG
VIEAATRGAGWGRKLPSGHGLGLAFCYSFMSYTATVVEVAVDAKGEVRVVSVDMAMDCGP
QINPDRIRAQMEGGAIMGLSLALASEITFDKGRVLQSNFHDYEVLRHHASPRVIRTHLVN
DNHDLPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVA
>A0A1X1PPB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia puraquae|TrEMBL
MSRGLIEAGRAGTGVSRRSFLKLGMSLGAAAGGGLLLGFSLPAAGDDARRSVIGGDGDET
ARAGVFAPNAFVQIDRAGKVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
EKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGATARTLLVAAAAKQWKVDPATCRAANGEV
QHPSSGRRASYGQLADAAAKLPVPKDVALKKPADFKLIGTPAKRLDSPEKVDGTAQFGLD
VRLPGMLYAVIVNSPVFGGTVASVDESAAKKIPGVRQVVRVDNAVAVIGDHTWAAKRGAS
ALVVKWNEGADAKVSMKDIVADLAQAAANGKGAVARKDGDVGNAFANAKTRVDAVYEQPF
LAHATMEPVNCTVHVRGDGCEIWVGTQVPTRARDTVQQLTGLAPDRIVVHNHLLGGGFGR
RLETDMIGQAVKVGKQVNAPVKVVWTREEDIQHDMYRPYYYDRISAGLDANGKPIAWQHR
IVGSSIIARFAPPAFKDGVDPDAVEVAAELPYDLPNQLVDYVRQEPRHIPTAFWRGVGPT
RGTFVVESFIDELAAQTKTDPVQYRRALLGKTPRALNVLDVATKAAGWGGPALPKGQGRG
VSVMHAFGSFFSIVVDVAVDNGEVQVKRVVCAVDCGMVVNPNTIEAQVQGGIVFGITGAL
YGEITIEDGRVVQSNFTDYRMLRINETPPIEVHLVKSGEAPGGIGEPGTAATAAALSNAI
FAATGKRLRKLPVGDQLKSA
>A0A0C2GQP9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter piscinae|TrEMBL
MSTTLRINGTSHQVDLPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGVGTPDTMAVVQKAWVANQVAQCGYCQSGQIMQAASLLAENPSPSD
AEIDEAMQGNLCRCGTYPRIRAAIHDAASMMREV
>A0A087PP27|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MAGQSTTITVNGVPHAVAAAADTPLLYVLRNDLALNGPKYGCGLGECGACTVLLAGRAAR
ACSISLQEAAPWPVTTLEGLEQNGVLDPVQEAFVEEQAAQCGYCLNGMVMTVRALLNVNA
SPSRAQILNALQYNLCRCGTHVEIIRAACRACGLTEQEECQT
>B1FVK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MAALNINGRAVAVQVEPDMPLLWVLRCELGMTGTKFGCGVGICGACTVHLNDKACLSCQT
PMSDLTTQKITTIEGLQGGEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKQKPHPSDA
DIDAAMSNIVCRCGTYPRVRAAIHQAAKRRPA
>A0A5S9NUU0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania aliphaticivorans|TrEMBL
MFTINVNGIAHTVDASEDKPLLWVLRENLKLTGTKYGCGQALCGACTVYIDGQPTRSCVM
PINAVGEQQVRTIEDISNEHIGNLVQNAWQELNVPQCGYCQSGQIMAATALLKDNNSPND
QDIDEAMSGNICRCGTYPRIRKAIHKIAAEQL
>A0A1S9GQA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium laguerreae|TrEMBL
MITLNINGNQHEVDADPETPILWVLRDTLGMTGTKFGCGAALCGACTIHLDGEAVRSCST
PLSAAEGLNITTIEKATDGSDRVGAAVSAAWVKHDVAQCGYCQSGQIMSATAFLASLPSG
SQPTASEIDTAMEGNICRCGTYVRIRAAVADAASNLV
>A0A368URS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter nauticus|TrEMBL
MAFTLTVNGRQHSLDVEPDTPLLWVLRDELGLKGTKFGCGAGLCGACTVHLNGQPARSCS
TPVEMAEGAEITTIEGLSADGELHPLQKAWVEQGVPQCGYCQSGQIMTAAHLLANNPSPD
REQIVTAMTGNLCRCGTYPRIVAAVESVAGAVGQYQPAGEGA
>A0A2L2BB30|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chromobacterium vaccinii|TrEMBL
MKVSINGKEVELNSSPDTPILWALRDELGLTGTKFGCGAALCGACTVLKNGLPIRSCVTP
ISTLAADDSITTVEGNADKVGQAVKQAWHELDVVQCGFCQSGQVLAATALLSANPHPSDQ
DIDLAMSGNLCRCGTYPRIRAAIHAAAKLL
>Q8KZS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus|TrEMBL
MIKFKLNGRDVSVDVPEDTPLLWALRDDLDQTGTKFGCGVGQCGACTVLVGGRATRSCIT
PISSIEGADVTTIEGLHPEGKHPVQEAWKDIQVPQCGYCQSGQIMQAVSLLKDYPDPTDE
QIDGVMGGSLCRCMTYVRIRKAIKKAAAAMQKEEASHG
>A0A3R9BZV8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium pisi|TrEMBL
MKTITINGKTHEVDVPDDMPLLWVLRDVLGMTGTKYGCGIAQCGACTVLIDNMAVRSCQT
TMDMIDAQQITTIEGVGETENGRKIQTAWLEKEVVQCGYCQSGQIMSATALLNSNAKPTD
SDIDEAMAGNICRCGTYVRIRDAIHTAAA
>F6EUX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium chlorophenolicum L-1|TrEMBL
MTKFTVNDRPVQYRMDPSTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCQV
TIAATEGKFVTTIEGLSPDRGHPLQQVFAADNVSQCGYCIPGFIMTAAALLRRTSDPSDE
EIDAALTNICRCGIYPRLRGAIQRAGRVMRGEEVVDAVPPSGITPDEAAKAVPALRKP
>A0A291FXQ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter piscinae|TrEMBL
MTIKLKLNGQTHTVEAAPGTPLLWVIRDELKLTGTKFGCGIASCGACTVHMDGEPVRSCQ
TYIEDTEGAEITTIEAVGDGAIGAAVQQAWLELDVVQCGYCQSGQIMSATGLLAENPKPN
AEEIDDYMSGNACRCAAYQRIRAGILRAAEILEG
>A0A291QMH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces formicae|TrEMBL
MRGTEGSSEQADSDAPGIGRRRFLGYVLAGPTLVAAADIGPASAAPARVPSADVTDLVDL
NDVMTLAAAPTSHLIKVEVHKDGTVSFALPRAEVGQGITTSTAMLIAEELDVPLDRVRVT
LADARPELAFNQLTGASNTTISTYTPVRVAAAVARGRLLEAAAIELGAAVRDLTLKAGVV
TDLAGGSVLIGALAEKAASATPRRVSVELKERERFTVIGTPQNRIDARDAVTGRKKFAMD
LAVPGALPTMVCRPPTINGKVGSVANLDQVRGMHGVTDVVVIPTGVAVRARTFGQCVDAV
RALEVSWRGGSAEGKSDESVLKELRKAELPLGLPAVPPSVEARFTFHFRSNSALEPNCAI
ADVRADRAEIWSGLKAPIVAQQTIAARLGLPQGAVKVHVVESGGSFGRKLFFDAALEAAE
ISQKIGKPVKLMWHRADDSRQGRAHPMATSRVRADYLGDSVLAFKQRHTSVATDFGHGLG
EVFTALAAKLPVGDVGFSQTFFHLTQSMPYSFGLHSRLLSETDKGFNTGSMRNVYSPDVT
CARELIVDRLAGKMDKDPYRFRRDFLRDDRSRAVLDKVAEVGTWGRTMPEGTAQGIAFHS
EYSAVSAVLVEIDCRPETVNRPIRDGVAGPRVTKAVFAVDVGLAVNPRGLEAQMMGCVMD
GIALALTSSLHLRDGHFLEASWDNYFYTRQWNSPPELQIIVMPTTTGKPGGAGELGVAAS
LAAVACAYGRATGTMPTTFPINHGTLSFEPKPTVPPVPPSPTDGLDHVR
>A0A1X6YP85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius halotolerans|TrEMBL
MSRAGKIARRTFLTGSIATAGGVAFGVYMYRRPSANPLAAGLHEGEAALTPYVLIRPDGV
TLITPRADLGQGAAHVQALLIAEELDIELDQVGLDPGPPSAAYYNTALSREALPFASTNE
SRLAETARSLMDAPIKFLGIQITGGSTTVPDGWQKLRVAGAVARETLKAAASLETGLPVS
DLRTRGGAVLLPDGTRLPYTGLAARAAEIDPVTDVTLRDPSAWRLIGKPTMRSDITAKST
GQQLYGIDVTLPGMLFAALRTNPRQGGEMLGYDASRAETMRGVHKIVPVTGGVGVLADNS
WRAMRAVEAIRIDWGPAPYRPHQGEHWRALENSFTDKRRDSRLRNDGDVDATLASTTPLE
AEYRAPYLAHAPLEPMNATLQIKDGKVDIWTGTQIPRFVQKNVASVVGVKPAQVHVHVTM
SGGSFGHRLEDMMVRRAAELAMQADGRPVKLTLSREEDMAHDYPRQIAMARGRGTVSGGH
VQAFDLGIAMPSIMRSQMRRLGMPMMGADLQIVAGAWDQPFAIPDYRVSGYRAPDLAPIS
SWRSVGASTNGFFHESFLDELIHAAGADPLEERLRLCNHAPSRKVLETVGEMSDWGAPLP
EGRARGIAFCLSFGTPCAEVVEVTVTESGIRIDKVHVAAEVGRVIDPVNFENQVQGGVIW
GLGHAILAETTYDDGMAEQRNFDSFRFMRMYQCPEIIVRGLENDSRVRGIGEPPVPPAAP
ALANAIFAATGIRLRQMPFVRDMDFV
>F7QQ16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobiaceae bacterium SG-6C|TrEMBL
MAAFTLKINGGEHRVDVDPQTPLLWAIRDGAGLMGTKYGCGVAQCGACTVHVDGQPMRSC
SLPVSAVGASEITTIEGIKGREAQAVQKAWVALDVPQCGYCQSGQVMSATSLLTLNPKPT
DEDIDLAMNGNICRCATYVRIRAAIHDAAKSLEG
>F7QQ15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobiaceae bacterium SG-6C|TrEMBL
MNIHVTHEIKKASSLSRRSLLKAGAGLAIGVYVARGGKAFAQAPAAAPPNITPNTFLIIK
PDNTVTVLCKHIEFGQGPFTGMATLVAEELDADWSQMRADHAPSNPVLYKNLLFGVQGTG
GSTAIANSYIQMRQVGAAAREMLVAAAAKEWNVPAAEITVENGVIKHASGKQGRFGELAE
KANQMPVPANPKLKDPSQFKFIGKEGVVKRLDSAEKTNGTAEYTLDINEPDMLTVVIARA
PQFGATVASFDATAAKAVPGVVDVKQVPTGVAVYAKGFWPAKTARDLLKITWDDTKAEKR
GTQELLTEFRTLSKTPGKTVKAEGDFEAEVSKPGSRLIEAEFAFPYLAHAAMEPLNAFIH
WKGDSVTSRYGSQFPTPDHATIAKILGVPMEKVSLKTILAGGSFGRRAQQTVHVAAELAE
VAKAMGPGKPIKLVWTREDDMRGGYYRPFSIHRMRGVVRDGKIQAWSDTIVGQSIMKGSP
FEAMTFKDGLDSTAYEGSNEIPYDVANFKCDLHQVDVGVPVLWWRSVGHTHTGYAVEAFV
DELLEAAGKDPVEGRLEMMSKKPRHAGVLRAVAELADWKNAKLEPGRARGVAVVESFNTF
VAQIVELSMGDEGPKVHKVWCAVDCGVAVNPDIIRAQMEGGIGFGLGHILYADVPMEGGR
VVPGNFDAYRSLRINEMPAIEVTVVKSSEKPTGVGEPGVPPIGPAVANAMAKLGQTRPRQ
LPIVPGASA
>A0A7W9ZCK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novispirillum itersonii|TrEMBL
MTHQRKKMRTETDTLSAAALSRRGFLKGAATAGVAALTLGVTARGVLAAAPAGADTVFNP
FVSIGRDGTVTVIAKHFEMGQGTTTGLTTLVAEELDADWAQMKSAFAPADNSRYANTFLG
AQGTGGSTAIANSYLQYRKAGAAARDMLVRAAAARWKVTPDSITLRDGILTSGKKRGTFA
DFVQAAAALTPPQDPVLKTPDQFRLIGVDHAAARKGHTGPGRKDSSGKTDGSARFAMDVH
LPGMVYAVLVRPPQFGATVTGFDDSAARALPGFVAAHALPNKAGVAVFARSTWQAFKARE
AITAQWDLSKAEGRSSAEITEALRQAAAKAELPVQNGPRRADITAAAAGAARTIEAEFSV
PFLAHAPMEPLNCVIEPTATGVRLHDGCQFPAITQPTVAAILGLKPEQVEITTLYAGGSF
GRRATPTSDYHAEAAMAFALLGGKTPVKLVWSREDDIKGGYYRSAALHSARIGLTADGGI
AGWDHRIATKSILKGSPFEAVMVHDGIDETSVEGVKGSLYTLPEMAISLTDFVTPVPVLW
WRSVGHTHTGFVMESLIDMIAAETGKDPLETRLSLLNPAAPTPQQARMAGVIRTARTLAG
WGQPVVPGKARGFASHLSFNTYVAMVVDISIDGTTVHVDHVHAAVDCGVAVNPDVIRAQI
EGGVGFALSAALRGEITLDKGQVAQSNFPDYEPLRLTEMPKVSVEIVRSAEAPSGIGEPG
VPPVAPALANALFAATGKRVTTLPFSTAGFRFV
>A0A0J5QIN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Puniceibacterium sp. IMCC21224|TrEMBL
MDSLGTLTRRSFLIGSVAVAGGVAFGTYVVKTPVRNPLLDTLADGEVAITPYVLIAADGI
TLITPRADSGQGAYSVQAALIAEELDIDPASATITPGLPGPAYYNGAVLAESVPFPAYDQ
SILAEAMRRFMAVPAKVLQLQITGGSSTVPDGFTRLRMAGAVARETLKEAAARRTGLPRD
QLDTAEGHVILPTGDRIAYTDLAADAAGIEPIRDVELRPPERWKRLGKTAVRTDMVAKCT
GTEVYGIDDSVDGMVYATVRANPGINGDVVSFDATDAEAMSGVLGVLPVPHGVAVVARNT
WTAFRAADSVRIEWGPPPYPASSAEIFDALEAVLDNDQSFDHRRRDDGDVDAALARGDVI
KANYRIPYLAHAPLEPMNALVHVTDDHCEIRTGTQIPLFIRARAAQITGLDQGKVLVHVL
PMGGSFGHRLEMTHVEQALHIAVAMKGTPIKLVWSRNEDMTHDYPRPAAVARARGRVVDG
RVETFDLSVGQSAMTPGWVRRLSGMSLPGPDTTITTGSWDQPFAIPNYRVTGYRAPDMVP
VSSWRSVGASGNGFLHDCFLDELIHAAGADPLAERIRLCMDDTSRRVLEAVGEMSGWDGP
GIGENRGRGVGFCLSFGVPVAQVVDVTMTARGIRIDKVHVAVDVGQVLDPVNLEAQVCGG
VIFGLGHAMNCALTYDNHTPQQTNFHAYEGMRLYQTPEIDVRVLTNGTKIRGIGEPGVPP
AAPALANAIFAATGQRIRELPLNKHVAFV
>A0A6J4TKW6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Sphingosinicella sp|TrEMBL
MRRARSSNGISRRTLLVGGGLGAGLVIAWGLWPRSYQPNLRVAPGETMFNAFLKIARDGR
VIVAVPQAELGQGVYTSLPQILADELGADWRTVSVEPAPIHPLYANQLMAENTLGSGLPS
TFQGIGRWAAREYATRSVLMLTGGSSSIRAFEPRMREAGAAARALLSMAAAERWDAEWER
LDTAKGFVVNGNERIAFGEVAEAAAGFELPANLPIRGGIENRLLGQAVPRIDLPSKVDGT
AQFAGDVRLPEMVFASVMAGPIGDSRLLRVDRAMAEKVPGVLRIFEHERWTGAVATNWWA
ADKAVRALWPVFRTHGTIAETPAIHARMTAALGNEVGSRFYSRGDMDAAFAGGGAIEARY
SAGAAPNAPLETLTATARWTGTRLEVWAPTQAPGLARAAAARAGGIGAGQVTIYPMLIGG
GYGRKLETAAIEQAVHMAKEMKRPVQLVWSRAEETIQDSFRPPAAAVIRAQVAQGGLIAG
WHVRIAAPATNAQAIGRLRGETGETEAEAAAVDGAVPPYAVPAVAVDHLPLETGLRTGIW
RSGAHSYTAFFTESFVDELARMAGIEPLSYRMGMLTENPRLARVLSTAAALAGWDGGGKG
SHMGLAAHSAFGSHAALVLEVNVGEDQRIRVSRAVCAVDCGRVVNPDIVKQLVEGGIVYG
IAGATGTRINFKSGLPTVRSLRGMGLQRLADSPEVTVEIIESQEEPGGVTELAVPVVAPA
IANAIFAATGQRLRSIPLAIGSA
>A0A7W8LCQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia youngii|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVQLDGVAVRSCVF
PAAAVGDRKIVTIEAVGATPTGQKVQQAWRELDVVQCGYCQSGQVMSAASLLARNPNPSD
ADIDAAMAGNICRCGTYHRVRAAIKQATKGA
>A0A839EKF7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium myrsinacearum|TrEMBL
MSKPSSSPSSKTGPSRRTFLQGGGLLLGFALFGASTKPVLAASTALPVDGDVTAAFSPDA
YIRIGTDGAITLILPNIEMGQGTHTGEATLIAEELEVGLDQVKAVDAPPNDKLYATAALG
GQATGGSTSMRATWEPLRKAGATARMMLVAAAAAEWSVPVTECVAKLGVVTHQPTGRQLA
YGALADAAARQPVPSDVTLKDPKDFQLIGKSSRRLDTPGKVNGAVTYGIDIRVPDMKVAT
VAACPVFGGKLGDVDDKKARAIPGVRDIVKLDNAVAVIGDHFWAAKKGLEALDITWDEGA
NAKIGSANIMAALKAASERKKPIMARQEGDVEGRMKAAAKKIEATYELPFLAHAPMEPIN
CVVHVRADECEIWVGTQVPAIAQGVAAKVTGFPLEKVILHNQLIGGGFGRRLVAESVAQA
TAIAKQVSYPVKVIWTREEDIQHDLYRPAYYDRISAGLGADGLPTVWVDHVAGGSVLGNY
IPSGWPEDKLDDDAVEGAAKPPYDLPVIQVDWVREDPPVPITWWRGVGPTHNVFVVESFM
DELAHAAGKDPVEYRRALTKNQPRAAGVLELVAEKSGWSTPLAAGMGRGISLHDAFGSYM
AAVLEISVSPAGEITLHRAVVAVDCGITINPNTVEAQIEGGLIFGLSAALYSGITFSDGR
VDQSNFHDYRILRNNEAPKIEIYHVKSSESPGGIGETATVSAAPALANAIFSATGKRLRT
LPFNRDELKGEGADKKSVSMVPPLAAPLAAALASIKPTDTELEKL
>W6V6I0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. (strain GM41(2012))|TrEMBL
MFNDTYPDELPRVLQHMLERDQIDGPTTLPRRSFLKILGVGGLALGAFPQLALAQQPGDN
RAEPLKPSQQPSAFVQIAPNGEVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
TSDIAYQDPLFGMHLTGGSNSIKNSYTQYRELGARARAMLLATAATRWNVDVASLSTQSG
MVFGPAGRKASYGELAEAAMALPVPETITLKDPKDFRIIGHATTRIDAKAKSSGQQDFGI
DMKLPGQLTAVVARPPVFGARISSLDDSAARAITGVKAVLRVPLDGGAEGVTVIADGYWQ
AKQGRDALKLQWDTSTVERVDSEKQLADYRELAGRPGPTLFEADMAPLETAPHQLEAEFV
FPYLAHAPMEPLNCTVKLSEERCELWVGTQFAGADSAAAARVLNLKPEQIQINVQTAGGG
FGRRGIATSDIVVLACEVAKAARMAGLNVPVRTLWSREDDIKGGYYRPMHLHRARIGFDD
SGKVLAWDHVVVGQSIISGTMFGGRVKNGIDPTTTEGLRDPYPLPMRLTVHHPKLNVPVL
WWRSVGSTHTAFVMETLIDEIARTTKQDPVAYRMKLFADQSPRHRAALQLAVDKSEYGKR
ELPAGRAWGIAVHESFSSVVAYVVQASVQNGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
AVMGLSMCLPGGAITLKEGVVQQSNFADFSVPRITDMPEFSIHVVPSAEPPTGMGEPGLP
PLAPAFANAVARLTGKPVRELPFKLT
>A0A839PGK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. RMAD-H1|TrEMBL
MAIVRVNGEERQYDGDPDMPLLWYLRDELGLTGTKFGCGEALCGACTIHVDGTAMRSCQT
TIGDAEGASITTIEGLSADGDHPLQVAWRELNVPQCGYCQSGQIMQAASLLKDSPQPTDE
EIDSAMSGNICRCGTYPRIRAAIKQAATATKGAKL
>K6XYT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola agarilytica NO2|TrEMBL
MSTLGKITRRTFVIGSAAITGGVLFGVYKYKQPYPNPLEKNLAQGETALTPYVLINASGV
TIIAPRAEMGQGVKTTLAALVAEELDIDVQNVRIEHGVPSNAYYNAAVLEEGVPFPPQDT
SSTAQMARDFMHVPAKFFGVQVTGGSSSTVDAFKKMRMAGATAREALLLAASAKLNVAKN
TLSTDNGEVISKDGQRIAYTELASLAASVELPDDVKLKPKSEWKQLGHPIPRVDMVEKCT
GTATFGIDVLQKDMLYATIKVNPHLGAKCHAFDANNAANMKGVKAILPLADVGAAVVATN
TWYAFKAAEKIDFDWAKTQYAQTTDELFESAIAAFNEEHQDSQNRDDGDVDAVIGAAGDA
TIHREYRAPLLAHATMEPMNATAIMKDGQLDVWVGTQMPTYALSEAARVSGIEAQNIRIH
TTYLGGGFGRRLEMDFIVYAVMVAKQLEGTPVKVTWSREEDMTHDSYRPFAVARFKGVTQ
GKNISALDVKVSSPSVMESQMGRLGVSLPGPDSTIVQALWDQAYTIENYRVTGYRVPMGI
PVSSWRSVGASQNGFFNESMIDELAIEANADPIEMRLSLITHQPTRNVLEAVANMANWGR
DVAENHGLGVALVTSFGVPVAEIVEVVNTPRGIKILNVYVAADVGIAIDSRNIEAQLISA
VNFGLAGAMMGEITLLDGKVQQTNFHNYDAIRMHQAPVIHTKILENGERIRGIGEPGTPP
AAPALANAIFAATGLRMREMPFNKHIQFV
>A0A2Z2P795|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Granulosicoccus antarcticus IMCC3135|TrEMBL
MDSSNTASMSRRGFLKSAAVLGGSMVIGFNAGGALAITTGSAPADSVGFNPFVKIAPDGT
VTVVVKHFEMGQGTSTGLTTLVAEELNVAWDQVAVEFSPSNKNYINLAFGGQGTGGSTAM
ANSYLQYRQAGAAARDMLVRAAAAEWNVDATEVVLKDGQLASGNNKGSIGDFIQQAAKLE
PAAEPVLKDAASFTLIGKDKLPRKDSMAKTTGKAMFAMDVKVPNMVYVTILRSPLFGGTL
KSFEIGAAAEVNGFVDAKALPDNSGVAIYADSTWASIKARRSVTAEWDNSAADSRGAAEM
LSEYTEKLNGKPTYDVTGKADLVEMETAAKAASRSLSVDFHFPLLAHAPMEPLNCVIEPT
EDGGVRVHDGCQFPMITHPTVAAITQLPEDKVEIITYYAGGSFGRRANTKSDYHAQAAMA
FVALGGKKAIKLVWTREDDLAGGFYRPMFAQRAHIGIGDDDKVSAWSQHTVAQSIFKGGP
MESFVVHDGIDHASVEGIADTAYQLPMALGLTDYESPMPVLWWRSVGHSQSGYTMEVLMD
MAAEAAGKDPVEFRLSHLDQTDENQGRLAGVLQLAADKAGWDGKQVAGKGRGIAVHKSFD
TYVAQVMDVSVNAEGAISIDKVVCAVDCGVAVNPDVIRAQMEGAIGYGLGAVMRNQITMK
DGVVEQGNFPQYEPLRITDMPVVEVHIVASDKAPSGVGEPGLPPAGPALANAIYAAIGTR
VTSLPMTSAGIKFA
>A0A2Z2NK71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Granulosicoccus antarcticus IMCC3135|TrEMBL
MIVTVNGKEHQYDGDPAMPLLWYVRDVLGLTGSKFGCGSGLCGACTMHLDGKSVRSCVLP
VQAAEGLTVVTIEGLDPDGDHPAQKAWREHNVPQCGYCQAGQIMQAASLLAENNTPTDKQ
ITEHMSGNLCRCGCYQRIEAAVKSAAIEQASKGA
>Q1DBH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Myxococcus xanthus (strain DK1622)|TrEMBL
MAAHQFILNGQTVLVEAPEDLSLLWVLRDVLGVTGPKYGCGVGVCGACTSHLDGEAFRPC
IHPVGGLSGREVVTIEGLGAQGLHPVQQAWMEEDVAQCGFCQPGQIMAAVALLKKNAQPS
DADIDAAMSDNVCRCGTYVRIRAAIKRAALLLRSGAGGG
>A0A7Z0DL22|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides panzhihuensis|TrEMBL
MGTHNSDGPARVTRRSFVGYVIGGATLITAADLGLAPPAANALPVPSVPQVPELYDLNDF
LTHCALPTSNLIAIEIDEKGHAHFALPRMEVGQGITTAVAMLIADELDLPVDDVHVTLAP
ARPELLFNQLTGGSNTIVSMYTPVRVAAAIARKALLEAAAILLGTNVAQLVAKGGVISLP
GGSSVTYGEAAAKAAKPTTEKVEVQLKKTSDHEIVGKPHRRVDARAAVTGKKQFAMDLDI
PNALPTMVCRAPELNGTPHAINNKGDVETMPGVTHVAIIPTGVAVRAKTFGQCIDAVRAL
DVTWNSGTVGGLSAKDIKAELKAGQIPLAVPKIGATSVDGEFTFHFRSGSALEPNCAVAD
VRDGEATVWGGLKSPIDAQGRIAKALGLPQTKVTVNVVQGGGSFGRKLFSDAAVEAAHAS
KAFGAPVKLMWHRADEPRQGRVHPMAVSKVRATVLAGSVLTFEQRHASVACDFTHGLGER
LTAEAAALPTGLSNLTFSESIFLLSQELPYNFGVITQLLNEPKPAVDRFNTSSVRNIYSP
DVATASELMVDQLAKKLKQDPVAFRRSYLKSKSVKRVLNRAAELGDWGRSMPAGTAQGIA
VHKEYKGATAVLVEIDCRPETVNRKVRDAVTGPRVTKAVVVADVGLVINPAGVKAQMMGG
FSDGMCQALTYGNHLVDGQFLEASWDNSAYTRQWNTPFDFECEVIESHGSQPGGVGEAGV
AASMAAVACAYARATGKMPTEFPINFRDPLHFEPKSFIPSVPESPTDGLAHTF
>A0A099L658|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Colwellia psychrerythraea|TrEMBL
MNSIENVSRRGFLKVAGISSSAFVLGMSLPITSSQAKSSASAVNHELNFFVSIANDSMVT
LVCHRSEMGQGIRTSVPQIIAEELEADWQKVTVVQAKADAKYGSQGTAGSASIRNHFTSI
RQIGAVARDMLEQAAANIWQVQKNAVKAQKHFVVHNATGEKISFGELASHAAKLTTPDSK
TIKLKANSDFSLIGKDVKLIDLDDIVAGKAQYAQDIQLPDMLIATIVRPPVVGGKVVSFD
ASEALKVKGVVDVIALKPRSIPVGINPLGGVAVLANNTWAALEGRKKLTIKWQLGDKQKH
NSSEFSKQLVKKVQRKGEKVATKGDVYNHQYNENNTLEATYTVPYIHHAPMETPAATAVI
HGKKCTIWAGTQNPQWAKGTVARELGLGEDEQDNIELNVTLMGGAFGRKSKADFIVEAVE
LAKTSKRPVKVIWSREDDIQHGYYHSISANYCKAELTEQSSADHWISRNAYPPIGWLWNP
EAKVPSDNQLALGFGDIPFALNNLSIEKHAVDSFVRPGWVRSVACINNGFALGSFVDELA
VKAKIPTRQMWLNLLGVDRHVDPNKNGFKYSNYNLDLTAHPIDTKRIKNLINLISDKAKV
EQALPENQGWGISFLRSFGSFVAAATKVSVVNNKVTVLEMHTAVDCGIVVTPDRVKAQME
GAMVFGLSIALMGEISVKDGQVEQNNFHDYPVTRINQAPEMHVHIIESDKPPGGIGEPGV
PPVAPSITNAIYHASKTRIRDLPVNKVFTV
>A0A2Z5SHE8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Geobacter sulfurreducens|TrEMBL
MSNGNGMSRRQFMKTSALAAGGLLLACHLPLGRRDAAAATAGVFAPNAFLHIGTDECVTV
IVNKAEMGQGVYTSLPMLVAEELCCDWKRVTFRPSPVAPEYNHTQFGPIMVTGGSTSVRS
EWSRLSLAGAAAREMLVAAAAREWRVEPAACRAEKGFVLGPGDRKLSFGTLAPKAASLPV
PKEPKLKQGAKTLLGQPLKRLDSPAKINGTAVFGIDVRAPGMLTAVIARPPVFGGTVKSF
DAAKARAVTGVLGVVAVDAGIAVVADGFWPAVKGREALEIVWNEGDGARVSTDALSEEYA
RLAATPGAVARKDGDAPAELAKAARRFEAEFEVPYLAHATMEPLNCFVDLQSDSCLIRTG
SQFQTGDRNAAARVAGLKPEQVTLETTFLGGGFGRRACPASDFVIEAVQVAKAVGKPVMV
IRTREDDMRAGFYRPLWRDRVTACLDERGYPLAWHHRIVGQSIMIGTPFEATIKNGIDDT
SVEGAADTPYAIPNLQVELHSPRNPVPVLWWRSVGHSHTAFVVESFLDELAHAAGKDPYQ
YRRALLAKHPRHLKVLETAARKAGWGKPLPKGRGRGIAVHESFGSFIAQVAEVSLSGDGQ
VKVHRVVCAVDCGRIVNPDTIEAQMESGITFGLSAALHGAITLRNGRVEQGNFDSYPPVR
MAEMPKVEVHIVLSGEDPGGIGEPGVPPIAPAVANALFAASGIRMRSLPLTPEAVKRAGD
RAA
>F8J9L2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hyphomicrobium sp. (strain MC1)|TrEMBL
MSSVTVNGELHEFSGDPNMPLLWYVRDILNLTGTKFGCGAGVCGACTVHIDGVAARSCQT
TLGDAAGKSITTIEGLSPDGNHEVQKAWRKVNVPQCGFCQAGQIMQAVSLLAKNRAPSDA
EIVEAMSGNICRCGCYQRIHEAVRLAAGGV
>A0A7W8T901|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. MM5384-R2|TrEMBL
MAVLNINGRKVKVDADPDMPLLWVLRCDLGMTGTKFGCGVGICGACTINLDDAACFACQT
LMSSLHTQKITTIEGLQGREAQALKAAWIELDVVQCGYCQSAQLMAACALLKHKPDPTDA
DIDEAMTPVVCRCGTYPRVRAAIHQAAAKVRNS
>A0A0J7J7H4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter subterrani|TrEMBL
MALRLTVNGQQHSLDVEADTPLLWVIRDELGLKGTKFGCGAGLCGACTVHLNGQPARSCS
TPVEMAAGGRVETIEGLGGSDRLHALQEAWIAQGVPQCGYCQSGQIMSAAHLLASNPAPS
RDDIVAAMAGNLCRCGTYSRIIAAVESVAAGPSNGQEA
>A0A1J5PJX2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MPYLAHATMEPMNATALFADGTLTIWAPNQAPTVVRDKCAEAVGIAADKVTVHTTFLGGG
FGRRAEFDYAVQAAKLAKALPGTPVLLTWTREEDMRHDFYRPGAIARMEGAADASGPTAF
KAAIAVPSVYANQAKRILGMAPPGPDKIAVEGAFDQPYAIPNYRVSGHISSVAVPVGSWR
SVGNSHNAFFHECFLDELAHAAGLDPVQLRLKLMATESPVSAKVVAAVAEMSGWGSPLPA
GHARGLAFTYSFGTPTAEVIEISQSAAGIKLEKMWIAQDMGQALDPRNIEAQMISGAIYG
LSAAMMGEITFSKGEVEQANFNDYDALRMQQMPVFETRILQNGAHLSGVGEPATPPAAPA
LANAIFALTGKRLRELPLNNAVTFA
>A0A482ZN08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MRVRCDLRIDLSRLHSITTCGRSCCSCDLRIDLSRLHSTTIATTATWRCDLRIDLSRLHS
HVMTVLALHGCDLRIDLSRLHSKAADQGTTLCCDLRIDLSRLHCERAIRNSEPCCDLRID
LSRLHFFLALIYRLRSCDLRIDLSRLHSARVY
>A0A482ZHT1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MKRNGCDLRIDLSRLHCSCNLVIQRFSCDLRIDLSRLHSKNLVPLLNSSCDLRIDLSRLH
>A0A482ZSI5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MRIDLSRLHYTGRLAVTLGCCDLRIDLSRLHLFTSSRIRVVSCDLRIDLSRLHLRNTDIF
GILCCDLRIDLSRLH
>H0TPA7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MTLSARIGLIIAAALIVLGAAAGALAWRPAIAAIEPPNPRSFDPELVRRGRQLVALGNCT
DCHTVRGGQEFAGGLPVVTPFGTVFSTNITPDPETGIGRWSEQAFQRAMKSGVDRAGQHL
YPTFPYDHFTHVTDADDRALYAYLMTRRPVRAPAPANHLTFPYDQRPLIAGWKLLFLQRD
EVTPDPAKSTVWNRGAYLVQGLAHCGACHTPRNALGAERTAASFAGGQAENWVAYALNAA
SPAPVPWTEDALFDYLRNGWQKDHGVARGPMAQVVNNLSLVDDDDVRAIAAYTADIFGPP
AAGRIQGAEAVRAEAAKPRSGPPQTSASTSAPKASGPDSTEGAAIYVAACASCHETGRAL
PYVGVDLHLSTGINAPDPRNVANTILYGLAARNGERSPIMPGFAASMTDAQVTALLNYLR
ATFSKQPPWSNIAQTVADARQAQAAFLQTAAEPPNIAIHTSPRGQP
>A0A8B4S4T4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Comamonas testosteroni|TrEMBL
MPIPNHFLADMPKGLRALAADTIDAGTKLERRDFLKLATASGFALGVFPSAALAQAKGNE
EVSTSALKPYQQPSAFVKIDRDGTVTVTINRLEFGQGVQTGLPMVLAEELDADWSKLHSV
HGNADPAYLDPVMGMHLTGGSTAIKNSYVQYRELGARTRSMLLATAAKRWGVDPQSLRTQ
AGQVIGPRGKKLGYGELADEAMKMPVPQQVKLKGVKDFRIIGRATGRLDARAKSSGSQSY
GIDMHLPGMLTAVVAHPPVYGSKIQSVDDAATKAIKGVRAVLRVPSVWGGELVAVLADGY
WPAKQGRDALKIQWDSAAVGKVDSARQLAQYRELAKKPGALKFDVDVSALNGAVHKISAE
YVFPYLAHTPMEPLNCTVRVTGAGKDAKVELWLGTQAPGWEVATAARVLGVAPQNVRVNV
QMAGGGFGRRANPRSDYVAEACEIAKAARASGVDAPVRMIWSREDDVKGGYYRPMHVHRA
EIGFDGKGKVIAWDHVIVGQSLAKGTAFEGFMVKNGVDTTTVEGMKEPYDLPMRLSVHHP
ELNAPVLWWRSVGSTHTAYVMETLMDEIARAVGQDPVAYRLQQFGDRHPRHKAALQLAVE
KSGYGKRRLAEGRAWGVAVHQSFDSVVAYVVEASMKDGTPKLHAVTAGVHCNLAVNPRSV
EAQVQGGALMGLGMCLPGAAITFKDGQVEQGNFNDYTVARLTDMPAITVHIVPSADAPTG
MGEPGVPPLAPAFANAIAKLSGHTPRELPFPKA
>A0A7W6YY20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MSEIVNLSRRRVLKGTLAGGVVLGLYVGGTAAAFAASPLASASSVKTVFAPNVYVSVAPT
GEIVLVVHRSEMGTGIRTSLAMILADELDADWNTVKVVQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGSARQMLVAAAASKWRVSPASCRTEPGHVVHPASGRRLSYGALAQAASHLPV
PGRDTLQLKSEDLWRYIGKSLPIVDLDDIVHGRATYGIDVVLPGMTYASVERSPVYGATL
KSVDSTEATKVPGVLRVVRIPAAPLPAGFQPLGGVAVIATNTWAAMQGRQKLKLEWNLGP
NGTYDSGAYRKALEDTARQPGKVVRNNGDTAGTLKNAAKHVSADYYVPHLAHATMEPLAA
TASFANGAVEVWTATQNPQQARTTVAQVLGLQEQAVTINVTLLGGGFGRKSKPDYVAEAA
FLAREVGAPVKLTWTREDDIRNDYFHAVCAQHMEGGLDAQGRTIAWLHRSVFPSIGSTFT
PDVVYGSAGELGQGVTDMPYEVANVQCENGAAQAHTRIGWYRSVYNIPHGFAQGSFVDEL
AAAAGQDPVQHLLALLGSPRHVDLHALGVDYPNYGASIDEYPIDTARFAAVVRAAAVRSN
WSAALPARHGRGIAVHRSFLTYVAAVAQVQVADDGSVRVTRVDLAIDCGRIVNPDRVIAQ
FEGAVVMALGNTLYSELTFSSGAADQSNFTDYRVARIDSVPETHVYIVPSAAPPGGVGEP
GVPPTMAAICNAISNAVGTRVRALPVDSALLKRA
>A0A7W8W482|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MSQGLLDAQNGAQPADTDTRHARGISRRGFLKFGVTVGAAAGGGLLLGFSMPAASQDQKA
GKSVIGGDANEAPQNGVFAPNAFIQIDNAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LGTVTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARVMLINAAAQQWQV
DPASCHAQAAQVIHPASNRSASYGQLAQAASALPAPQNVPLKDPKDFKLIGTPAKRLDSP
EKVDGTAQFGLDVRLPEMVYAAIANCPVFGGTLASVDDTHAKTIPGVREVIKLDNAVAVI
GAHTWAAKRGLQALDIKWNEGAGAQVSMKRIVDDLAAASQHGGAVARKAGDVGRAFGDAK
SRVDAVYQQPFLAHATMEPVNATVHVRGDACEIWLGSQVPTRVVDAAVAVTGLPADKIIV
HNHLIGGGFGRRLETDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDTISAGLD
ANGKPIAWQHRIAGSSIMARFAPPAFKNGLDPDAVEVAADLPYDLPNQLVDYVRVEPHAV
PTAFWRGVGPTRGTFVVESFIDELAAHAKIDPVQYRRDLLGKSPRALNVLNLAAQAGNWG
SALPKGQGRGISVMHAFGSFFAIVVEVALEQGEVTVKRVNCAVDCGMFVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRINQTPPIDVHIVKSGEAPGGIGEPGTA
ALAPALTNAIYAATGTRLRQLPVGRQLHSA
>A0A7Y9QZR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphaerotilus montanus|TrEMBL
MIPLQVNGRAQQLDVDPSTPVLWALRDSLGLTGTKFGCGVAQCGACTVHVDGQAVRSCIT
PVSSVAGRAVTTIEAVTAGDDRVGRAVRDAWVQHDVAQCGYCQSGQIMSATAFLKSLPRG
RQPDAAEIDAAMAGNVCRCGTYARIRAAVADAARALA
>B3R2W0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MRIRGIEALAGGQAGNSGEAHADAGVATLDRRSFLKLTGLAGGGLALGMAPLAQAQEGAR
PKPPPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRATLAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVIT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIIGKPTPRLDARGKMEATTPFGIDTQL
KDMVVAVVARPPRFGGKVKSFSADKARAVPGVLGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSRVSSQVLFEEYAKLAGQPGTVARAGEGDIAAAIQRAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQAVKVWVGSQFQTVDQAAVARTLGLSPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVGAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEARVHRVTAGVHANRVVNPMSAE
AQIQGACVFGLAMTKPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSQENPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A5P9CE94|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. THAF187a|TrEMBL
MGKIETPDSAARGILNVSRRSLLKGTGGLALGIFFAPLIRGMDALAAGGPLEPNAFVRID
LDGSVTVLAKHLEMGQGSYTGLATLLAEELDADWEAVRVEGAPADVKRYNNLAFGPMQGT
GGSTAMANSWEQMRNAGATAKAMLVAAAAQRWAVPASEISVSKGVVSHPGSGRSAGFGEL
VEAAAALPVPEQVQLKQPQDFKLIGKVELRRKDSPGKTDGSAVFTQDFKLPGMLVAMVAY
PPRFGGVPRSVDSSKAKAVRDVVGVVEFRDLPHGRAGVAVLAKNTWAARQGRDALVIDWD
ESQAFTLGSEEILAQYRESAGKPGLPAAARGDADAALAKAAKTVEADYEFPYLAHAAMEP
MNCLVKLSADRCEIWNGEQFQTVDQAIISGYLGFKPEQVSLTQLYAGGSFGRRASSRSDY
LLEAVAITKAARDKGVDAPVKMVWAREDDTRGGFFRPMYLHRARIGLDEAGKLQAWHNRI
VGQSIIAGTSMEPFLVKEGVDHTSVEGVSNLSYAVPNLKVELSTPSNIRVPVLWWRSVGH
THTGYVAETMIDEAAVAAGQDPYAFRHALLENHPRHRGALELAARQAGWDKPLAAGAAGE
KRGRGIAVHESFGSFVAQVAEVTVKADGSYRLDRVVCAVDCGIAINPDVIKAQMEGGIGF
ALAAARHSAITLKDGRVEQSNFHDFQVLRMNEMPRVDVHIVPSAQNPTGVGEPGVPPLAP
ALANALFAATGVRLRKLPFPAQIKA
>A0A5P9HZP3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. THAF9|TrEMBL
MSRVGKIARRSFLVGAVAAAGGVAFGVWRYKTPYRNPLLSGLNDGEAALTPYVLIRPDGI
TLITPRADKGQGAYQVQAMLLAEELDVTLDQIAVDPGPPDVAYWNRALADEAAAFLAPGG
GFGEQVAGSVVSAGAKFLGLQITGGSTTTPDGFDKLRAAGASARETLKAAAAAQSGIAAS
ELTTRDGAVILPDGTALPYTELAAVAADMDPVTDVALRPASEWRLIGQPIPRLDMVAKST
GTQDYGIDVNLPGMVHATVLLNPALGGALGSYDTAETFKIRGVQTVVEITGGLGIVADNT
WRAMEGAKAIAASWPDGPLPRTMEAHWQALSDSFAEDTQDSRKRDDGDMDAALGADDVIE
AEYRAPYLAHAPLEPVNATVRVDDDAVEIWTGTQIPRNVLTNVSGITGVPEENITLHVQM
IGGSFGHRLEDMVVRHAAEIAMQMKGTPVKLTYSREEDMTHDFPRQIAMARMRGTVREGR
VEAFDLGIAMPSVIVSQMGRQGLSVPGPDSQIVAGAFEQPFALPHHRVTGYRAPPLAPIS
SWRSVGASTNGFFYNAGLDELIHAAWADPMEERLRLCNDTLARGVLEAVAEMSNWSGPNP
ADGVGRGVAFTKSFGVPCAEVIEIEATEAGLKLTRAWVAAEVGTVIDPLNFENQVAGGVI
FGLGHAMNCELTYADGRAEQTNFDAFQGLRLYQAPVIEVRGLENGDKVLGVGEPPVPPAA
PALAAAIFAATGTRLREMPFSKFVEFA
>A0A381A7H7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella pertussis|TrEMBL
MRIAIQNLSRRRFVQGAGGLLLGLSLPPLARRAMAAGPQAGDGFAANAFVRIGADGRVTV
LAKHLEMGQGAYTGLATLLAEELDADWRQVRVEGAPADSARYGNQALGGLQGTGGSTAMF
DSWEPMRRAGATARAMLVQAAAQRWQVPADTIEVAEGVLSHPASGRRAGFGELAEAAARS
PVPEDVPLKDPARFRLIGKHRLPHVDSAAKSDGSALYTQDMKLPGMLVAVVAHAPRLGAA
VARVDDAAARAVPGVRAVVRFGGAALRHAGVAVLATNTWAARAGRDALRIEWDEGPAYRQ
GSADILARYREAVGRPGSMAARKGDIDAAFAGAAKVIEAEYTYPYLAHAAMEPLNCLVRL
DDERCEIWNGEQFQTADQRAIAQYLGMPAERITLTQLYAGGSFGRRASSHADYLLEAVAI
ARTARAQGLNAPVKLVWMREDDMRAGYYRPLNLHRARLALGADGALQAVHVRMAGQSILL
GTPLADWVRDGVDPVSVEGLSDLAYAVPNLQVELHTPTDVPVPVLWYRSVGHTHTAFSAE
TLIDEAAVAAGQDPVAYRLALLAAHPRHREVLQLAAVRAGWREPLAAGAPGTRRGRGVAV
HESFRSVMAQVVEVTIAADGALKVDRVVCAAVHCGLAVNPDVVRAQMEGGIGFALSTALH
GAITLKDGAVEQSNFHDYPVLRLAEMPAVEVHIAPSTQPPTGVGEPGVPPLAPALANAIA
QATGQRLRTLPLGTTVKA
>A0A839Z8W7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Angulomicrobium tetraedrale|TrEMBL
MHNIQPADYARMLERLAPASATLDAPSRRGFLKAAAAISGALVIGVHLGPSESLAAAMAD
GPMPNAFVRIAPDSTVTVLIKHLDMGQGTTTGLTTIVAEELDADWSQMRAAFAPADAQLY
NNLLFGPIQGTGGSTSIANSWEQLRKAGAAARHMLVAAAAEQWKVPAGSITINKGVMTSG
SHSAPFGAFALAAAKQPVPKDVTLKDPKDFRLIGTRLPRLDSADKTDGKAVYALDIRRPG
MLTALIRRPDRFGAKVKSFDAAAAKKVPGVVDVVAVPNGIAVLAQNTWAATQGRDALTAI
EWDESGAEMRGTPELMAEYKKLAAAPGGTPAARRGDAAKGLAGAAKVIEAEFAFPYLAHA
PMEPLNCVIEKTADGVTIWTGSQFQTIEQAVTAGVLGLKPEQVKIETLWAGGSFGRRANI
PADYVAEAATILKAIDGKAPVHLVWTREDDIKGGYYRPMFYHTVRAGLTADGKIAGWQQQ
IVGQSFIIGTPFESFIVKEGVDGTSVEGAADTNYAIPDFAVDLHTTKVGVPTLWWRSVGH
THTAQVVEVMIDELAHAAGRDPVALRFELLKDKPRHAAVLKLLAEKANWGPKAGPGKGRG
IALHESFNTVVGSVIDVSVVDGKIKVDKVVCAVDCGIAINPDVIAAQIEGGVGFGLGAAL
HDEITMDKGVVEQANFDSYIPLRMSEMPVVEVHVVPSANAPTGIGEPGVPGVAPALSNAI
FDATGQRLRSLPFKLEDFKA
>A0A0S4TUR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MDLDVNRRLVKVECDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHVDGEAVRSCVLP
VAAVAGRRITTIEGLAEAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADINAAITNLCRCGTYPRVRTAIKRAAQALREGRA
>H0SDE5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MTPRLNRRSFVIGTAALGGGLALGLDIPFGGPQVVRAADGSPEVNAWVVIRPDDTVVIRI
ARSEMGQGSLTGLAQLVAEELACDWSKVTTEYPTPGQNVARKRVWGDFSTGGSRGIRSSQ
DYVRKGGAAARMMLIQAAADEWKVPVAECTAANSVITHKASGKTTTYGKVAEAAAKLTPP
ADVKLKDPKDWTLIGKGVKRLDTADKVTGAMVYGADIKLPGMLNAAIKDCPVTGGKLKSY
DEAKIAGMKGVKKVVAVDGTAVAVVADTWWHAKTALDALPIVWDEGPNAKVSSESIGKWL
AEGLDSGPAFVGNENGDAKAALASAVKKVEAVYNYPYQNHATMEPMNATALYTPERCEVW
CGTQNGEAAFAAVLEASGLPADKCEVHKLILGGGFGRRGQTDYVRQAVQIAKAMPGTPVK
LLWSREEDMTHGRYHPITQCKLTGGFDADNNLTALHMRISGQSILFSLRPDALVNGKDPA
TFQGLAPSGEATIGYSVPNLLIEHSMRNPHINPGFWRGVNVNQNAIYLECFMDELANAVG
QDPLEFRRKLMSKNPKHLAVLNAVAEKIGWGTPAPEGVHRGLAQLHGYGSYVAGAAEISV
IDGTKIKIHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGRIEQTNFDS
YNSMRIAEMPKVESIMLPSGGFWGGVGEPTIGVAAPAVLNAYFAATGKRIRSVPLRDQNI
TFA
>A0A221V2H1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arenibacter algicola|TrEMBL
MPKYEINVNGVSKSVDVAEDTPLLWVLRDHLDLVGTKYGCGIAQCGACTVHLDGKAVRSC
SLPIASLAGQKITTIEGLSENGDHPVQLAWKEVDVPQCGYCQAGQIMTASAFLDNNPNPT
SDEIKTAMHGNICRCAAYTRIHKAVEIAATKIG
>A0A221US01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arenibacter algicola|TrEMBL
MIPTKTDFSRRKFLKSSSGVALFIGVAGILPQLISCKDPNKIKQQLAQQPITAWVKLSED
GLITIYNPAAEMGQGSMTSLPLIFAEEMDADWSMVKVEFSPQESETYGSPGWAPGSKLMF
TVGSRTTNSYYNVMRKAGAQARYVLMNSAAKHWEVPISELTTSNSYVHHGKTNQKISYGD
LVPFLEMPETLPDYSEAQLKNHKEFQLIGKDIPRTEIPAKVDGSAIFAIDIRMPEMIYGV
LERGKLHGSKPSLTNEAEILAMEGVLKIIPLDYAIGILAKTLEQALNAKQSLKIDWSESK
ASGHNSQEVYATYEKIASQNEKGKVIIEIGDVAKARRTAAKTYEVDYKNDYVYHAQMEPL
NAVVQVAEDGGSAEVWVGSQQGTDTKLGVPKILGIAPEKVNVHLQYLGGGFGRRSMNDFV
EECAILAKEMAPLPVKLIWTREDDVTYGAFRPLSLQRLTASTDAEGNITAFSHSVVGDGG
NLVASAVVNDHYDIPNQFAEWREASNGIRLKHWRAVGHGPNKFAIESMLDEIAWKQGTDP
LELRRKLMAKAPRALATLEKAAEISHWSKPLVEGRAKGMAFVEHGSLGTGVCEISVDRST
GIIKVHHFWIALDAGVVVQPDNVKAQMEGGIIMGMSSVLKEQITIVDGQVQQSNYHDYQL
LRIQDIPDSIETVILESSEIPEGVGETATPMVACAIANAFLKLTGKPLRHLPFSPERVLQ
ALNS
>D0I5Q0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia hollisae CIP 101886|TrEMBL
MRDFLNGYVPEEALLKNTTQSGTSRRNFIKLMSTAGAGLTLGVHLPSVAAGDKETAGTSF
VPNAFVRVGSDDTVTILIKHLDMGQGITTGLATIAADELDADWSKVTTEAAPANANQYNN
LLFGPVQGTGGSTAIANSFMQLRMAGAKAKAMLINAAAKVWEVSPSEIMTSSNTLSHNAS
GKSASYGEMAELAALQTVPSDEQVTLKTPEQFTIIGKTGTLRKDQGKSNGTATFTQDVQL
EGMLTAVVAHPPAFGAQVVSFNATTAKQSPGVVDVVQIPNGVAVIAKDFWSAKTGRDKLT
IEWARSAFNKSTEQLKKEYTALAQRPGQPARNEGDANKVLGASDDVIEATYYFPYLAHAP
MEPMNCVVLVGDGKAELWYGAQLQTIDQYAVAKVLGIKPENVTINTLFAGGSFGRRGNPH
SDYVVEATMIAKAKPGVPVKLVWTREDDMQAGYYRPMYVHKIRGAVDADGNLSAWEQRIV
GQSIAAGTAFEQFMVKDGVDSSSVEGASTLPYAIPNLAVELHTVQQPVPVVWWRSVGHTH
NAFSTETFFDELAHKAGKDPVELRRALLKNHPRHLGVLNLAVEKSDWGKPLAKGKGRGVA
VHESFRTFVAQVVEVTVENGQITVDRVVCAVDCGVAINPDIIKTQMQGGIGFGLSPALVS
EITLQNGATVQSNFHDYQVLREMQMPEIEVHIVPSAEPPTGVGEPGTPPIAPAVANAVFA
ATGKRLYDLPMKMS
>A0A7Z7JEM2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MDGIARLSRREFLRGSLGLMTLAVTSGGLVTVARAADPAPKKFGADSMPGGTVDDPLAFV
SIGADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVVQAEADETRYGNQNVDGS
RSVRHFLMPMRRVGAAARHMLEAAAASRWSVPVSEVRAVQHEVVHQPSGRRLGFGELAAD
AARQPVPKGDALRLKPRTGFRYIGKNAVRPVDQEAIGTGRATYGMDLRLPGMVYAVVARP
PVVGGKLRRVDSRKALALPGVLKVVEIPAFQGAPAFQPLGGVAVVARNTWAAMQGRAALE
IEWDDGPNGGYESVAYRRTLEAASRAPGKAVRNQGDAQRAWDQAPPAERLAADYYVPHLA
HASMEPPVATVRIRGGSAEVWTSIQNPVAAQAAVAKRLELKPGNVRVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPEGTPVKLVWTRDDDIHHDYLHTVSAERLEAVVDRQGQVKSWLHR
SAAPTIASLFTEGAKGQQMFESAMSAINMPYRIDNVRVETAEVPAHARIGWFRSVANIPH
AFAAQCFIAELAHRAGKDHRQFALDLIGPARKIDPGTLADTWNYTESPERYPYDTGRLRG
VIEAATRGAGWGRKLPKGHGLGLAFCYSFMSYTATVVEVAVDTKGEVRVVSVDMAMDCGP
QIHPDRIRAQMEGGAIMGLSLALASEITFDKGRVLQSNFHDYEVLRHHASPRVIRTHLVN
DNHDLPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVA
>A0A375F0T7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQPAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLAQVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAALQLGVDASTLEAENGVFRVRGTQASIGYAALV
AGEHVELPLADDVPVKPVESYRIVGRAAARVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLAIDRDSVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLCVRW
KPVPPLPALNDPEPALRANPATRRELLTEGELPAGGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLSGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELAMEAGADPVEFRLRHLPDERAADLLRAVADAAGWQRGAAGARGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGHIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVLLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMAATKG
>A0A375D126|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQVGNSGEARADAGVATLDRRSFLKLTGLAGGGLALGVAPLAQAQEGAK
PKAPPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLAAAAAQRWKVDPASCKVEQGVIT
SGSQRATFGELAPAAMALPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKSFSADKARAVPGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSKVSSQALFDEYAKLAGQPGTVARAGEGDIAAAIQRAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVMGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSVVKGEPRVHRVTAGVHANRVVNPLSAE
AQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSQDNPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A375BWP3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLEMTGTKFGCGVAACGACTVHVNGQATRSC
VTPASALAGARITTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A375FCC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSHLHASRRRFLQAAGAVPAALVLGFHLPLAKAADADAPARDPDDVNAWLRIDADGGVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
YEPLRRIGATAREMLREAAAQTWSVPAAQCRAVQGVVRHEPSGRTLGYGALAARAATLPR
PANVALKDPRDWKLLGRPTDRLDIPLKTRGAAVFGVDVKVPRMLVGSVMACPVFGGTLRR
VDARPALALRGVRRVVPLDDAVAVLADSYWTARKGLAALQPDWQLPQGQLASDAALMAGY
REAARSASAMALRHGDPDTQMQGAQAYTAEYEVPYLAHATMEPMNATADVRADRAEIWGP
TQVCGEIAQRLSGVLGLPADRIVVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPDAAGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHVAVRHAMVNTIVPVGFWRGVGYTQNTFFAESFIDELAHHAKADPLQFR
LNLLAERPRPARLLQRLAQHVGWGSAAAGRFHGVALSQAWGSLCATVVELSVQGQRITLH
RVVNAIDCGTVINPATVERQLEGASIWGLSAAMTGAITIADGCVQQANFHDYPLLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGQRLRSLPLARHGFELA
>W7IR58|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinokineospora spheciospongiae|TrEMBL
MTTHRCPRPLRPHRVVIRSRFEEALMTSSRIGRRTVLTLLVAAPTLTVAGNLLDTPTADA
VLPSLPAPADILDLGDVLILAGTPTAHMLVLRVDPDGTATLRLPRAEVGQGITTAAAMLV
AEELDLPVERVRVELDDARPELLFNQLTGSSNTIRSVYGPIRNAAALARARLLAAAAARL
RVPTGALTTRAGVITATDGRAARYGDLAAAAADPKLFVGLVTPKPERDFTVVGTPTSRID
ARAMVTGKQRYTLDLDVPGALPTMVRRAPTINGTVRSVDNEAVVRAMPGVLALAVIPTGV
AVVAETFGQALDAKEALAVTWNGGTVDDESDDTITAKLRAAAPGFGGPPLLGRAVDAEFD
FAFVSHAPMETNSAVADVRADRAEVWAGLKSPINAQEGIAKALGLPVDKVTVHVTQGGGS
FGRRLFADAALEAALVSRAVGRPVKLMWSRVDDMRHGRARAASHHKIRAVHALGNVVSFE
HRVAGVETDFGHGVGDAITAEAAQLPVAGGLVFAQVVFLTTIKSPYNLGLTGQSLTEVPL
KMHTGSWRSVYSANTRGAEEIVVDELARSMGRDPVAFRREFLKTDRQRAVLAKAATEGQW
GRAMPAGFAQGIAFHEEYKSCVVYLVELDARDPADPRVVRATIAVDTGRVINPRGLESQL
LGALTDGISTTLRAGLHIDRGLPLEGSYSQFHYARQKDSPTDVRIFTMPTTGTPGGAGEL
GVPAAVGAIANAYARATGRKPRRFPLNFPVDFDPFPR
>A0A2R8BGC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ascidiaceihabitans donghaensis|TrEMBL
MSKIGKIARRTFLIGSAAIVGGVAFGYYAYKKPVANPLLKGLADGETALTAYVKIDADGI
TLITPRADSGQGAYSVQAIMIAEELDVELDQIKVDPGVPSRAYYNTALAQEAAPFPSTND
SFTANSMRGVMDAMMKFLGMDITGGSTTVPDGFTKLRVAGAVARETLKAAAAQKTGVALT
DLRTSKGAVVLPDGTSLPYTELAAIAGTLDPVDEVQLRDPSTWRLMGKTTQRLDIVPKST
GTQDYGIDFTLDGMVHATVRTNPRRGGAMQKFDASDAKAMRGVSQVFEISTGVAVIADNT
WRAIQAASAIEIEWDAAPYPAEMEDHWQTLSDSFVADRVDSTMKDEGDVQAALDTGDVIE
AEYRAPYLAHAPLEPLSATVLVQDNRADVWTGTQIPSFLRGNVADITGLDKDDVHIHMLM
MGGSFGHRLEARVVQEAAEIAVKMKGTPVKLTYSREEDMTHNDTRQIAMARGRGTVKNGQ
VESFDLGIAMPSVIASQMGRQGISVPGPDTQIVAGAWEQPMRIPNYRVTGYRAPELAPIS
SWRSVGASSNGFFHDVFLDELIHAAGADPMAERLRLCWHDPSRKVLEKVADMSNWGAPLA
ANQGRGVAFCMSFGVPTAEVVEVTATEDGIRLDNVWVAADVGTVVDPVNFENMVQGGVVW
GLGHAILSEITYSDGMVEQDNYDSFEAMRMYQVPNIEVAGLENADQVRGMGEPMVPPAAA
ALSNAIFAATGQRIREMPMNKFIDFV
>A0A7W6TT43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR48|TrEMBL
MNKHVSPRLNRRAFVIGSAAVGAGLAIGLDLPFGGPAVVRAADGSPEIGAWVVVRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELECDWTKVTTEYPTPGQSVARKRVWGDFSTGGSRGI
RSSQDYVRKGGATARVMLIQAAADAWKVPASECAAANSVITHTPSGRTTTYGKVAEAAAK
LTPPADVKLKDPKDWKLIGKGVKRLDTVDKTNGAMIYGADIKLPGMLNAAIKDCPVFGGK
LKSFDEAKIASMKGVKKVVKVGDTAVAVVADTWWHAKTALEALPIVWDEGDNAKVSSESI
AKWLAEGLNNDQPAYVGNKNGDAKAAIAGAAKKVEAVYSYPYQNHATMEPMNATALYTAD
KCEVWCGTQNGEAAFAAVLEASGLPADKCDVHKVMLGGGFGRRGQTDYVRQAVMIAKEMP
GTPVKLLWSREEDMAHGRYHPITQCKMTGAFDANNNLVALHYRLSGQSILFSLRPEALQN
GMDPAAFQGVAQSGEAAFGYSVPNLLVEHAMRNPHVPPGFWRGVNVNHNAIYMECFMDEL
AQAAGQDPLEFRRKLMGNHPKHLAVLNAVAEKIGWTTPAPQGVYRGIAQVMGYGSYVAGA
AEISVTDGSKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGKIEQ
TNFDTYNSMRINEMPKVESVMVPSGGFWGGVGEPTIGVAAPAVLNAYFAATGKRIRSVPL
RDQNITFA
>A0A0L1KG39|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Qipengyuania citrea LAMA 915|TrEMBL
MDPRAGLAALPVSRRQLLAGAAVGGGLAVGWWLWPRRYSSPLVPGPNDHGFGGWLTIAED
GVVTVALPQLEMGQGVTTVLAQVVAVELGADWRQVAIEPAPPAGLFANTALAAKWAPLWS
RLPGLADDPDGLLAERFARSNAFCATAEGLSLAAYEQPLRAAAAAARALLAMAAGERWGV
GWEECEVAAGLVRHGEQELGFGELAAQAATLDPPDPPPLRVEPASEDPSPAEAELAPAFP
RLDLPAKVDGSFLFAGDIRLPGMVYASIRHGPLGKAELTAFDKEAVAGLKGLVGVVKSKR
YLAAVADSWWIADRALAAMRPVFAGPAAVESAGALRALDTALAEGEGERIVTEGDPDGAL
ARPDYAQDYSVAPAVHAAIETASATARFDGGKLELWIAAQAGELTRRAAAKAIGISPQDV
VLYPTAAGGSFDARLERRHAIEVAQIAQQIGRPVQLTWPRQQELQLVPVRTPVSARLEAG
FAPASGGRIAAWRTRLAMPATMREFGHRLFDNNTPEAAMEHAAGEADALACEGAVPPYGI
AHVAVDHLPVTLPFPTGPMRGNAAAYTAFFTESFIDELAERAGRDPFLYRIEMLGQTPRM
ADCLRRATRLAGWDGGRRGTGQGLAMVRMGGPGEGGGPGDGGGRIACVAQAALGEGGLRV
TRLHAAVDIGRTVNHDIARQQIEGGLIFGLSLATGSSVAYEDGRPVPARLAGLSLPTLAD
CPEIVIEFLASDAPAFDPGELGVAVAPPAIANALYSATGVRFRRLPLLSEGL
>A0A2X2G9T2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MAIAEVQLPREGAVKTLTEHPLMLSVNGENIHIQVMADTPLLLVLRNDLALNGPKYGCGL
GECGACTVLIDGIAARSCVIPALGVTGRAVTTLEGLGDRDHLHPVQRAFIEEQAAQCGYC
LNGMIMTTKALLDRNPSPSDREIRQALSGNLCRCGTHIEILGAVQRAIILCRSEETSPHD
>A0A0N1FZS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinobacteria bacterium OK006|TrEMBL
MTDVPAGSGRTSGRGERARVGRRAFIGYVLGGATLAVAADLGLGTPAYAAVPSAPQIPEL
YDLEDLQTDAALPTSALIKIVINEDGTASFELPRMEVGQGITTSTAMIIAEELDLPVDKV
HVALAPARPELMFNQLTGGSNTTVSTFTPVRVAAAIARKALLEAAAIELGSAVALLKSKE
GAIFAPDGSSMTYGSLATKAACRTVKAVEVELKATSSFSVIGKPYRREDARLAVTGRKQF
TLDLHVPDALPTMVCRPPTLNGSPKSVHNRATVLAMPGITDVAMVDTGVAVRAETFGQCI
DAVRALDVEWNPGPVAGESDETILARLRKAELPLAVPKVPLLAGTVEADFTFMFRSSAAL
EPNCAIADVRSDRATVWAGLKVPIVAQGDIAKAVGLPQNAVTVNVVTGGGSFGHKLFADP
AIEAAKISKAMGKPVKLMWHRADEPRQGRVHPMVTSRIRATYLAGQVLTFEQRQTSVVTD
FSHGLGEMITATADRLPTGLGALGFSETIFTLTQELPYNFGVVTQLLNETDARFNTGSMR
NIYSPDVACANELVVDQLARKMGRDPLAFRLAFLKNDRVKAVLQKVADVGKWGRSMPAGT
AQGIAIHSEYKGATAVLVEIDCRPETVNRKVYNAVTGPRVTKAVIAVDAGLVINPQGLEA
QMLGGVSDGIALALTSSLHLRDGHFLEASWDNYFYTRQWNVPFDFECIVMPSDSEQPGGA
GEAGVAASVAAVAGAYTRATGTMPTRFPINHDTVSFEVKPFIPPIPESPSDGLSHTY
>A0A1X6YMV2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax jejudonensis|TrEMBL
MGRASTIARRTFLIGSATILGGVAFGAYFVSRPTSNPLLKGLPEGQAALTPFVKITPDGI
TLIVPRADVGQGIASTQAMLIAEELDIDPSTTTLDPGQPHQAYFNAAVAADSLPFPAWNH
GFVASTVRDLMGQVARLTSSQFTGGSTSVADLHETLRLAGATARETLKAAAAARTGVPRS
HLRTEDGQVVLPDGTRIPYTELSAEAAAMDTVLDVTLRPASEWTRLGKPYQRLDIVAKST
GTQGYGIDVVLPGMLHATVRANPGRGGTMAGYDAETALSMQGVRSVVEVNEGLAVIAENT
WFAFQAAQALDVEWLPPAYPASSAAMWQVLADARTDEFRNSRLRDDGDIKAALDGATVIE
AEYRSPFLAHAALEPLSATVLVEADRVQIWTATQIPAVVRDAAVALTGLVPSQVTVHVLP
AGGSFGRRLDHDYVVQAIQIAATMPGTPIKTTWSREEDMTHDYPRPLHMAVGRGAVSDGR
VLAYDLDSVSPSLISSWFGRIASIPPGPDTALVWGAYDQPYAIPNYRVTGYAAPPLVPVG
SWRSPGACSNSFFHESFLSELIHAAGSDPLEERLRLIADANSRLVLEAVGEMSNWAGVDI
GPGRGRGIAFAHTHGVPVAEVIDVTVTERGIRIDEVWIAADCGTVLDPVNAEAQLTGAAI
FGLGHAMNCELTYENHAVQQTNFHAFEGMRLHQTPLFHTRLLERAEQVRGLGEPATAPAA
PALADAIFAATGQRLREMPFNKSVDFA
>A0A3G7K8H4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MTRHHEVDQGRRAFLRGGALVLAFTLVPAARQALADSEVDTLGTLVLAPDLPGSLRTNPY
LDAWIRVAAEGVTVYTGKAELGTGVKTALLQIAAERLDLAPGAITLLTADTALTPNEGYT
AGSHSIFDSGTALFNAAAQVRQLLLESAARSWAVDAALLTTHEGQIQGPAGQRMAYAEAV
KGVDLHHYAQVQSPSMPPSAFKLIGHSLPRLDIPAKVSGGAAFVQDLRLPGMLHARVIRP
PRPGCRLEAFDAEALKALPGVVRVVQDGNYLAVVARDEWQAIKAMRSGYEQARWSAGEAI
PEARDIHALLTRLPARRYPISHEGNPAAGASASYRARFSKQYLMHGSIGPSCAVAWFKDG
VLTVWTHTQGVYPLRAGIAEMVGLAPERVRCIHTEGSGCYGHNGADDAAADAALIAMRLA
GTPVRVQWMREQENLWEPYSSAMLTEVQASLDAQGRLQDWAYELWTTPHNERIVNAGRLI
PARLLARPFVSAPSIPIAQPEGDGDRNAVPLYSLASTRIDMNFVTRMPFRTSAMRSLGAH
INIFAIEACIDELAARAGADPVALRLAHLSDPRARAVVERVRDASGWPHKGNEPGAGIGF
AFARYKNIMGYCAIAVLLRVHPQTGEVQLDRVVTAVDVGQIVNPDGLRNQVEGGIVQSAS
WTLFEKVGYDPGGVRSYDWSGYPILRFAQLPRQVEVHLLDQPGQPFLGAAEIVQGPMAAA
IGNAVANATGRRWLNLPLTRSEQPA
>D5RMM1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseomonas cervicalis ATCC 49957|TrEMBL
MDLTINGVTRSVEAEADTPLLWVIRDELGLTGTKYGCGAAQCGACTVLVDGQPTRSCVTP
VESIAGLPVTTIEAIGQDPVGRRVVEAWVAAQVPQCGYCQSGQVMAATALLQQTPQPTEE
DIAAAMSNLCRCGTYNAIAAAVRQAAAQG
>Q399V5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MRDDHAPDAPDAPDAPHAPHAPHDHGTPRRRFLKQSSALLAAGIAIGFRMPDAVAAGKST
SGDPHPSTGEFEPNAWVRVLPDDTIKLVVHKHDSGTGTRTALAAMVAEELDVDPFRVDVI
TPEDPFFADYIHPLWKVFSTGGSTSVAMEYDRLRRAGATARAMLVEAAAHQWGVPAAACT
TADGAVLHAASGRRATYGSLASAAAQLPAPKQVVLKDPSQFRYIGKLRKKRGAAQKADGS
FPYSIDVSLPGMLVAVVTRAPVIDGRVRSVDAKAALAIPGVRDVLQIPPRPDVLGGNQAG
VAVLADDYWSAHKGQAALTIEWEDSLFETFDSSALAARQAAWVDDPAARVVPTIADGDPA
KAHTAGARTIEASYAMPHKAANPLEPINLTVWARNGGIEFWGGLQVPSTAMEAAEVIGGI
PSHRVTLHELVSGGSFGARESKYWLFEATWLAVKTGKPVKLMNSREDEMRALFYHAASYH
RARAVLDAQGNLASLWLRGVMPASPQQWEPGYLERTDRMDFSTTEALTKWEFAYAAPHRD
IGWIRMETGVPTGWFRAVSYIPNVFAVESVMDEAAHAARRDPVEFRLAHMRDRPRHAAVL
REAAQRAGWGQPLPDGVALGIATNQAYDSYVAVVARVVRKDGAVRVEKLTCVADCGIAVS
PAGVDEQLYGGLMWGLGHATSDRIDFRHGRVQQSNFDTYRVMRMSDMPDTDIHIVQGDPA
KPGGVGELSSPAVTPAIANAVFRLTGKRLRETPFDLSAVA
>A0A5M9J1L9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas extremaustralis|TrEMBL
MELRINQKSYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAIEADAVGQRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPAPSDA
QIEAAMVNLCRCGTYNAIRTAVHDLAKQENA
>A0A6S7BN96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ultramafica|TrEMBL
MGSLNINGRAVAVQADPDMPLLWVLRCELGMTGTKFGCGVGICGACTIHLDGAACLSCQT
PMSSLHTQKITTIEGVQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKHKPDPSDA
DIDAAMSPIVCRCGTYPRVRAAIHQAAAKRRPA
>A0A840U1U4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhabdobacter roseus|TrEMBL
MALHKENNPEGGTLESQPLDRQALPRQPLDRQPLDRRHFMKAMGLTGVGLVLGFSAQAGG
RGTSVVNVGQEGTAVLSFELHPFVVIDNAGGITIINHRPDMGQATWQAVPMMVAEELEVS
LDQIQIRQSDGLRKYGAQLSGGSSTVRTGWTRLRQAGAAAREMFTQAAADRWKVSKADCY
AQEGKIFHKPTGKSFTYGELVEDAARLEVPKDLPLKAKKDFKLLGKALPRPEVPAKVTGR
AEFGMDVEVPGMLYASIERSPMIHGKVLSFDDANAKKVPGVKQVLKAERPLPYKTCESVA
VLADNYWAATQGRKALKIEWNNANYATDLTTDRYFAQLREAAKVPDAPAYSQAGDVKAAL
GTAAKKLEAQYETPFLAHAPMEPEVAVAHVKDDGTCEIWAPVQGPDGAIEQVAKYLGIAP
EKVKVNVPFLGGAFGRKAYLDFVLEAVYLSKQAKVPVKVIWTREDDIQQGPFRPGMLSAM
RGGVDAQGTITAFEHTLIGESIMGQVYGAFPAGKPDPWAGEGISHEESPYAFANAKVGFK
RVTTDIPIVWWRSVYPSNSSFGHESFVDELAHAAGKDPLDARLELLKDAPRFQNVLKTLA
EKASWYQPLPEGMGKGVAIAKSFGSVCAHAVFVKKDGVGVKIDRVVTVLDCGMYVNPDNV
RAQTEGNIAMGISAAIKPAITFAGGKAQQSNFHQYQILRIDEMPKVEIHLVENEEAPGGV
GEPGLPPVAPALCNAIFSATGTRIRKLPFDLKKLS
>A0A6I8LRK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis camponoti|TrEMBL
MARRRFLGFVLAAPTLAVAAQVGGAELAPSKADAAIPSLPQPEDIFDLGDLQNLAALPTS
GLISVQIGADGRAAFAVPRAEVGQGMTTAVAMMIAEELDLPLDKIDVTLADARPELLMNQ
LTGGSNSMRSIYTPVRTASAIARQRLIAAAAAKWGVPASQLTTSGGVVRGSGGRTASYGS
LAKAAASATTISVAATLKPQSQFTVLGTPQNRLDAHAAVTGTKQFTLDLDVPNALPTMVA
RPPTINGTPRAILNAAEVEAMSGITDVVAISHGVAVRGRTFGQCIDAIRALKVTWGAGTV
DGESDATVLKKLKAAQLPMAVPGLLDQYIDAEFTFAAASNSPLETGAAIADVRPDRAEIW
SCLKVPIVAQEEIAKLLGLPQDAVTVHVTQGGGSFGRHLFHDAAAEAAEASQKMGKPVKL
MWSRTDDFRQGRIHPMCVSRVRATYLLGNVVSFEQRHTSVQTEFSHGLGEMITATAAKLP
IAGNLSFAESIFLLSQSSPYNFGVTTQLLNEIPLKFNTGSMRNIYSPNVVTAEELVVDQL
AKKFGKDPVAFRREFLKDDRLRAVLDKAVQVGNWGRALPAGVAQGIALHAEYRGAVAVLV
EIDCRPATVNRPIRDGVTGPRVTKALVVVDPGFAINPRGLEAQMIGGLNDGIAMCLTSSI
HIKDGLPLEGSWDNYFYTREWNTPPETQVVVMPNTSSSPSGAGELAVAPSFAAVACAYAR
AVGKMPTSFPINHGTLSFEPLPLQPSTPPSPTDGLDHAY
>A0A7Y7LP70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MAKLNVNGVVREYEAEDDTPLLWVIREQLGLTGTKYGCGMAQCGACTVHIDGQPVRSCVY
PAAAVTNAQKITTIEGLSADGSHPIQKAWAALDVPQCGFCQSGMIMAAAALIREKPKCTD
ADIDAAMTNICRCGTYNRVRKAIHVAVRGGDPASAGLAIERIEGSKA
>A0A7Y7HVS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MRIEWLNQGMIASASASGMSRRGFMKAGAVVGGGFVLGFVVPGGGRFANAQQPPAKVYEP
NAFLHIAPDNRVTVQVNRLEFGQGVQTALPMLIAEELDADWSLVNGALAPAGDQYKDPAF
GIQITGGSGSVAHSYLQYREIGAKARAMLIAAAAEQWKVPADQIRTVKGTLIGPSGQKAT
YGSLAEAAMKQPVPATVKLKDPKDFTIIGKPVKRLDARAKSTGKQQFGMDFKAPDSKVAV
VARPPVFGAKVAKFDASKAKAVKGVIDVLEVKTDRGGSGVVVIADGYWPAKTGREALAID
WDTSGVEKVSSEKQLAEFKTLSQKPGSPVRKADTSKLAGAAKKISAVYEFPYLAHAPMEP
LNCVVDLRKDSCTVWAGSQFQTIDQGAIAATAGLKPEQVTLNTMMAGGGFGRRAVPTSDY
LVEAVNVAKVWQAAGHKEPIKVIWGREDDIKGGYYRPSHVHRADIGIDAKGEIVAWNHVI
VGQSIITGTPFEPMMVKDGVDATMVEGMGEPYEVPLNLSAHSVKANVPVLWWRSVGSTHT
AYVMETLIDEAAHAAKMDPVAYRKKLVGEKGKRHVAALDLAVAKSGYGKKALPKGQAYGV
AVHESFNTVIAYVVVASVKNGQPKLHSVTAGVHCNTAVNPLTIEAQIQGAALMGLGMTLP
GAAITLKDGVVEQQNFSDYTVARMTDMPKIDVHIVPSNDPPTGMGEPGLPPLAPAFANAL
FKLTGKRLRKLPFDLASA
>A0A7W6G7S8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MNLPFQTPVNDPVNVSRRGFIAGAGVGALVLGFGVPMGAARAQGAAAKVVPGTRVPAFLA
IRPDNTILFQSPFAEGGQGVWTAMAQIVGEELDADPASFTVENAPPGPDYQVVFGQMRIT
GGSFSVRSSYATMRKLGATARAMLVQAAAQKMGVPAGELTTQPGRVIHKASGKAMTYGEL
APAALDMPAPANVALKDPKDFRWIGKRQARLDVRAKSTGKAQFSIDMKVDGMLHAAVQHA
PRLGQTVGKIRNEAEVKAMKGVHSVHVLPGAVAVVAERFWHARRAVEAAQVDWAEATGET
YRPMPADFSTEAFAQYLANYQGKEEVAETAGDMAAGFAGAASTVSATYHSQFVNHAQLEP
PSALARYNADGTLDMWFPNQAPEMFLAEIAKASGLAPDKIHIHSPLLGGFFGRHFIYPHG
TPWPQALELAKRVGRPVKLIWTREEEFLRDPLRPMAAVRFRGALDAKGMPIAIEAISVTE
GPTEGIADKRAAKLDDAALEGLTGKKYALPAKRIAQVFVKSPTTLAYWRSVGNSMNDFFY
ETFLDEMADKGGQDPYALRLKLLEGNVRLTNLIKAAVDLSGGWKAGPFTAPDGSKRARGI
AMASPFGTETAAIAEVSIADGQIKVHDVWQAIDPGSIVNPAIIEAQVNSAVALGLSEVLI
EEAVYKDGLRAARNFDGYPILTPDRMPRVHVRIVESGAPMGGIGEPGLPAVPPAVANAVS
RLVGKRLRKMPLAGFA
>E3FKK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stigmatella aurantiaca (strain DW4/3-1)|TrEMBL
MGDSKKPETAGPTSMDRRQLLTWVVASPTLVVAARLALDAPPADTSPSVDVIPLDLSIAL
RTDGRITVTLPRTEMGQGITTGVAMLVAEELDADLGQVDVHTADVSTDWLNQLTGLSSTM
RSLAAPLRAAAAGARARLVTAAAHRWHLPARTLTTAHGEVLAPDGRKLGYGELAQEAAGV
WLPEVSTQPKPVERYTVVGRPTGRIDARDIVTGAARYTLDLDVPGAVAAVVARPPTLRGS
VQSYDASAAVTMPGVVGVLPLPSGMAVAAQNFAQALAARDALDILWNPGPASHLSDEDIR
ARLREAVSGPVLPPLLTVKTLEARFDFPYLAHAPMETQCCVAHVTPEHAEIWSGGQDPKF
TRHEVATALGWALTPQRVTVHTVRAGGGFGRRFFPEAAVEAAQVSRGLGRPVKLMWTRND
DMRHGRYRPASHHRLHAFLGLGGSILGWHHRSAIPTLELPHGFGDALTSLVGRVLPEVTS
AFFFELTQHLPYRFGLLPQQHLHEVPLPIPTASFRSVFSSQVAVANELFVDHLARGLERD
PVELRRTFLTSNRLKAVLNKVVLEGAWGRALPPGVAQGVAVHEEWDSAIAHLVEVDVTGE
VPRVVRAVIAADVGLPINPRSIENQLQGATVDAMSTTLSAGLHIDAGAVREGSFADYRWL
RMKHVPAQMQVHLVRSDDRVGGVGELGYPSAAAALANALARATGTLPTRFPLLDPGA
>A0A7W6WAD7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseospira visakhapatnamensis|TrEMBL
MTHLFERLSAAARPLASRPTTSPAPTRRDVLRIVGGAGAGLTIALALPGAAPTAALAAEE
ADDGKTFAPNAFVRVTPDNTVTVVIKHLEMGQGVYTGLATLVAEEMDAAWEQVRCEHAPA
DADLYNNLFWGAVQGTGGSTSLANAFLQMRRAGAMARGLLRRAAADAWGVGVDAVDTAAG
QLIHPETGERVPYGQMTARAARLRPPSPESVPLKDPEDFTLIGRADLRRKDAPEKVEGRA
IFGSDVAFNGLLTALVLRPPRFGGTLKTLDASAAQAMRGVRAVFAIPRGVAVVADGFWQA
RKARMALKVEWDESDAVRVGSKALWDEYRDLADTPGQTFRDDGDVHAALAKAASSVVEAT
YTVPYMAHAPMEPLSAVALRTASGIEVRAGSQVPTLDALAIAEAAGVRPDQVTLHTLYAG
GSFGRRATPDGDVVAEVAAIARGLFERGIAAPVKLVWTREDDIRGGRYRPMALHRLRGAL
DEARRPLAWHQRVVTQSILKGTPFESVLIKDGIDGTSVEGVIDLPYAIPNMLGDLHGPDP
GVPVLWWRAVGHSHTAFAVESFVDELAHAAGADPLVWRMDLLADHPRLLGVLMLAANKAN
WSTPLDAGRGRGVAVHASFGSFVAHVAEVTVSASGVTVDRLVCAVDCGLPVNPDVIRAQI
EGGTCFGLSAALRGRVTLDDTGKVVQSNFHDFEVLRFPSLPPIEVHIVPSAEPPSGVGEP
GVPTVAPAVANAIFAASGKRLRDLPLKLG
>A0A6J5GTY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MATRLLDRRSFSRRDFLQLGVSVGVAAGGGLLLGVSFKANSASEATSSGGITAAIRSAGS
VIGGDGRVPAPGGDLAPNAFIRIDREGHVFIVVPKVEMGQGVYTSIPMLIAEELEVPLDN
VTLQHAPPDAALYADGLLGMQVTGGSTSMRAMWEPMRRAGAVGRTLLLQAAAQAWGVDSA
GCVARNAVVRHVASNRTLTYGQLVECAASLAMTPDLAKSIVLKSPSAFTIIGKPVKRLDS
PEKLNGVARFGIDARPPGMVYAVVVNCPVIGGSLARVDDTVARAVPGVSQIVSLDNAVAA
IGTHTWAAKTGASALAIEWNPGPNALMTTRTLVGDLQRASQRPGAVARKAGDVATAFSQA
SRKIEAVYELPFLAHATMEPMNCTVHLHDGRCEIWCGTQVPTRVVDAAAKITGLPPGQIV
LHNALLGGGFGRRLEVDVLMQAVRIAQQVNAPVKVLWTREEDIQHDMYRPYYYDRIAAAL
DSSGKPAGWTHRITGSSIVARWAPAWFKNGLDPDAVEVADKLPYDIPAQLVDYVRQEPRG
VPTAFWRGVGPTRSTFVVEGFIDELAHETKTDPVTYRRALLGRSPRLLHVLDVATRAAGW
GSSLPTGSGRGVSVMNAFGSFFCMVVQVSVDNGEVRVERVVCAVDCGQVVNPDTVQAQVE
GGAIFGLSAALFNQITFSNGRVEQSNFNDYRVMRINEAPHIDTHIVASSEAPGGMGEPGT
AAVAPALVNAIFAASGRRVRRLPVGNQLQTSESA
>A0A238JF55|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas phthalicica|TrEMBL
MPSLGKIARRTFLIGSAAIAGGVAFGVYAAQRPFANPNLDDLPKGSASFNPWVIIDSDKI
TLIATHADKGQGIFSAQAAMIAEELDVDLDQVEISFGVPDKAYYNRAAIDVMAGFPMYDN
SPTAETVRGFLGGIVKLALPLMATGGSSAVPDSYDKLRQAGATARETLKLAASQQSGVPV
EQLKTERGAVILPDGSEIAYTALAGAAAGITPMADIPLRDPKQWRILGKPMERADMVEKS
TGTLTYGIDFRTEGMLHATIKVNPRQGGAMVGFDASEAEGMPGVKKIVEITGGVAVIADN
TWRAIQAAEAIEFDWGEAPYPAEQDAHWELLSNTFTDAHLNAEARVEGDVEAAEGEEVVG
EYRSPYIAHAPLEPLNATILVGENRVDIWTGHQIQQYVEQFVAEITGVDQENVHLHNMFI
GGSFGHRLEFDFVKQAAEIANQMRGTPIQMTYSREEDFAHDFPRHITMGRGVAKVKDGKV
TALDIQIAGQSVMRSQMGRMGMSLPGPDAQLHEGAWDAPNFNLPNLRVRSYRTEALAPVS
SWRAVGAGPNVFIYETLLDEAIHKAGADPLAERIRLMGHEPSVKVLEAVGEMCSWTGPNI
GEGRGRGVAYGFSFGVPVATIVEVTATDAGIKLDKAWVAADVGKVIDPVNLENLAQGGTI
FGLGHAINCEITYADGMAEQTNYHDHEGMRLYQCPEIAFRPLEIGTKIRGFGEPPIPPSA
PALGNAIFAATGQRIREMPFYKHIDFV
>A0A1Y0XUI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus subsp. pasteurianus|TrEMBL
MIKFKLNGRDVSVDVPEDTPLLWALRDDLDQTGTKFGCGVGQCGACTVLVGGRATRSCIT
PISSIEGADVTTIEGLHPEGKHPVQEAWKDIQVPQCGYCQSGQIMQAVSLLKDYPDPTDE
QIDGVMGGSLCRCMTYVRIRKAIKKAAAAMQKEEASHG
>D4Z655|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)|TrEMBL
MTKFTVNDRPVQYRMDPATPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCQV
TIAAAEGKFVTTIEGLSPDRGHPLQQVFAADNVSQCGYCIPGVIMAASALLRRTSDPSDE
EIDAAITNICRCGIYPRLRGAIQRAGRVMRGEEVVDAVPPSGIAPEEAAKAVPALRRP
>A0A8F8UC79|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea coxensis DSM 45129|TrEMBL
MTGPADETIGRRRFLGYVVAAPTLVAAAELTPPSPAAAATGEATASAGIPSPELTELIDL
NDVMTAAALPTSNLISVEVGTDGIVSFALPRAEVGQGITTSSAMLIAEELAVPLDRVRVT
LADARPELVFNQLTGGSNTTVSTYTPIRVAASVARLRLLEAAAAELGAPADRLRLEGGAV
VAPSGRRLDIGALATKAASAGTRQVSVELAPRAGFTVIGRPHNRVDALAAVTGRKKFTMD
LDVPDAKPTMVCRPPTINGKVGSVSNLAQVRAMPGVTDAVVIATGVAVRAETFGQCIDAV
RALQVTWRPGTAAGKSDESVLRELAAAELPLGLRPPTPVVEGTFTFHFRGNSALEPNCAI
ADVRDGRAEIWSALKSPIVAQQAIAAKLGLPAGKVTVHVTEGGGSFGRKLFFDAALEAAE
VSQKIGKPVKLMWHRADDARQGRVHPMATSRVRAAYLGQTVLSYKQRHTSVSTDLGHGLG
EIFTAMAARLPVGDIGFSQTFFHLSQAMSYDFGAASHLLAETDKDFNTGSMRNVYSPDVT
CARELIVDQLAARMGKDPYRFRHSFLRDDRSRAVLARAAEAGGWGRAMAPGTAQGIAFHA
EYKSVSACLVEIDCRPETVNRTVRDAVTGPRVTKVVFAVDVGLAVNPRGLEAQMMGGVSD
GIALALTSSLHLRDGYFLEASWDNYFYTRQWNTPLDLQVIVMPSTSEQPGGAGELAVAGS
MAAVACAYGRATGTMPTTFPINHGTLSFTPKPTVPPVPPSPTDGLDHAR
>A0A509EIM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MISLRVNGAERSYDDDADMPLLWYLRDELGLTGTKFGCGVAACGACTIHLDSIATRACVT
PMSSVDGRAIITIEGLSLDGNHPLQVAWRDLNVSQCGYCQAGQIMQAASLLQDTPEPSEA
DIDAAMSGNLCRCGAYPRIRAAIKQAAGSTRRAVEGERP
>A0A6J5A5B8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sediminicola|TrEMBL
MRNDKQALNGAHGAARRRFIKQSSALLASGLAIGFQLPEAFAKDANVSGDPKPQAGEFEP
NAWVRVLPDDTIKLVVHKHDSGTGTRTALAAVVAEELDVDPFRVEVITPENPFYGDYIHP
LWKVFSTGGSTSVSLEYDRLRRAGATARAMLIEAAAKQWNVAPSACSTENGFVIDKASGK
RANYGSLASVAAQLPAPKDVALKDPSQFKYIGKLQKKRGADLKARGAFPYSIDVSLPGML
VAVVTRAPVIDARVRSVDAKATLAVPGVRQVLQIPGRPDLLGGNQAGVAVLADDYWSAHQ
GQAALKVEWEDSPLETFDSGTLAARQAAWLDDPVAHVVPTIQTGDAKTAWPHGARVIEAS
YSMPYKAQNALEPINVTAWAKDGRIEYWGGLQVPSTVQEAAEVIGGIPAERVVLHELVSG
GSFGSRESKYWLFEVTWLALKVGKPVKLMNSREDEMRALFYHSASYHRAKAAFDAHGNLT
TLQLRAVMPASPEQWEPGYFDRPDRMDYSTTEAISKYEFAYDAPHVDIGWVRHETGVPTG
WYRAVSYIPNVFAVESFMDEAAHAAQRDPIEFRLAYMKDPRHKAVLREAAERAGWGKTLP
AGTALGVATNQAYSSYVAVVARVVRKGDAVVVETLTCVADCGLAVSPGGVEEQLYGGLMW
GLGHATADRVDIRHGQVEQKNFDTYRVMRMSDMPEVDILIVQGDPAKPGGVGELSSPSVA
PAVANAVFRLTGKRLRDTPFEMERAGVQKAANAPNAKVVGKQTS
>A0A840GN74|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR18|TrEMBL
MATVLTINGETKSFDAPPEMPLLWVLRDILGMTGTKFGCGIAQCGACTVHVDGKAVRSCV
LPVSAVENRAITTIEHVGSTPAGAKVQKAWLDLEVIQCGYCQSGQIMSAAALLAATPNPD
DSDIDAAMAGNICRCGTYVRIREAVKQAANGRQS
>A0A7X0D0Q7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium wenxiniae|TrEMBL
MIENLVSRRNFLKGTALATAGLVLAVQLPDSVRRAVAAAGDQQSFVPNAFVKIDGDGITL
IMPHTEVGQGIYTSSAMLMAEELELDLDQVKVEAAPPDISKYMDPILYDQATGGSTSTRS
DWMRLREAGAAARIMLVEAAAEGWGVPPGECRVAQGVIYHDTSGKKAPYVDIAPRAASRQ
VPKEIKLKEPSQFRLIGTKAKRIDTPAKVNGSLIYGIDTRFPDMGYATLVMAPVKGGRIA
RMDEAAAKAVRGVRDIVRTDDAVAVIGDHMWAAKQGVDALGVEWDHGPNSSVTNASIVTE
MDEVSMKQGVVVRDQNDARSVIDKAATKLDAIYHSPFLSHSPLEPLNCTLHIENDKAELW
VGTQVPVRAQKAVADATGLSPEKVTVNNQLMGGAFGRRLDIDSIEIAARLLKDIRYPVKV
VWTREQDMTHDFYRPYYYDRVAAGLDDSGRLVGRTHRVTGSSVFARWAPAAFINGVDPDA
VDCAAETPYDEDAVLADYVRHEPAGVTTSWWRGVGATHNLFVVESFVDEMAHATGQDPLE
FRRRMLTKNPRGLAVLNLAAEKAGWGEKLPPGRGRGISLQVAFGSYLAHILDIEITSRKQ
IKLVRSILAVDCGIVINPDTVRAQMEGGVLFGLGTAMFNEVTFTDGKVDQTNFDTYRILR
INEAPKVEVYQVESVEKPGGVGEAGTAAAAGALANAIFSATGRRIRSLPLSQGAVK
>A0A839FBM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium sp. P30BS-XVII|TrEMBL
MSKPSSSPSPKTGTSRRAFLQGGGLILGFALFGAGVKPVLAASTALPVDGDVTAAFSPDA
YIRIGTDGQITLILPNIEMGQGTHTGEATLIAEELEVGLDQVKAVDAPPNDKLYATAALG
GQATGGSTSMRATWEPLRKAGATARMMLVAAAAAEWSVPVTECAARLGVVTHQPTGRQLA
YGALADAAAKQPVPTEVKLKDQKDFQLIGKSSRRLDTPGKVNGAVKYGIDIRVPDMKVAT
VAACPVFGGKLQDVDDKVARAIPGVRDIVKLDNAVAVIGDHFWAAKKGLEALNITWNEGA
NAKLDSSNIMAALKAASEHKKPIMARQEGDVEAKMKAAAKKVEATYELPFLAHAPMEPIN
CVVHVRADECEIWVGTQVPAIAQGVAAQVTGYPLEKVILHNQLIGGGFGRRLVAESVAQA
VAIAKQVSYPVKVIWTREEDIQHDLYRPAYYDRISAGLGEDGLPTVWVDHVAGGSVLGNY
IPSGWPEDKLDDDAVEGAAKPPYDLPVIHVDWVREDPPVPITWWRGVGPTHNVFVVESFM
DELAHAAGKDPVEYRRALTKNQPRVAGVLELVAEKSGWGTPLAAGMGRGISLHDAFGSFM
AAVLEISVSPAGEITLHRAVVAVDCGVTINPNTVEAQIEGGLIFGLSAALYSGITFSEGR
VNQSNFHDYRILRNNEAPKIEIHHVKSTESPGGIGETATVSAAPALGNAIFSATGKRLRT
LPFNRDELKTGGTEKKSVSMIPPLTAPLFAALATTKAEEPSETASEEL
>G2E5E6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thiorhodococcus drewsii AZ1|TrEMBL
MISVTLNGETLEFDLDPDTPLLWVLRDHLGLTGTKYGCGEGECGACIVHLDDKPVNACIT
PLSEASGRSVKTIEGLSPDGRHPLQLAWIIEEVPQCGYCQSGQLMTAAALLATHPRPTDA
QIETAMSEVICRCGSYNRIRRAILRASNPEAQNG
>A0A6S6XWA5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Denitratisoma oestradiolicum|TrEMBL
MIRFTLNGKPVQLDVAPDTPLLWALRDGQGLTGSKYGCGQALCGACTVHLNGQPVRSCVL
PVSAVAGASVTTIEGLASRVGQAVQAAWQKLDVAQCGFCQSGQVMAATALLTSNSKPSDT
DIDTAMGGLICRCGTYVRIRAAIHEAARMLG
>K1LDK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MHLPNTDRRTFLKTTGQFLIGFNLFPLLNCSPSEKDPNILQAYSGIPERPHGGRDLIDSW
IRLDAEGHVTVLTGKKELGQGIRTALIQIAADELEVDIQRCHIINGDTGQTANEGYTSGS
NSIEGSGKAIREAAAEAKFFLLQLASAKLECSLEDLNLSDGTIEGLQNKKTSYWELLDGQ
YYEKTISGEAPILDNKRHQYVGKPIPRADILELVKGKAHFVHDLRLPDMVHARVLHPPTY
GARLLSIDKAKVEALPGVLGIFVDGSFIAVIAEREFQAVKAWEKLKESTVWEKPSINPLP
DRLFADMRSKAQKPEIIQENPNISEKLNNSPIRLKSAFQRPYHMHGSAGPSCALAKWEEE
KLTVWSPTQGVYPLQSTLADLFQVELTNIRCIGVPGSGCYGHNGADDVSAEAALIAKAFP
GKTIRLQWMREDEHQWEPYGSAMIMELEAGVSKEGMIQAWDSKIWSDSHSTRARGDAGHF
ISARYLENPFEFKKGGFSGGAYRNAIPLYDIPALNLKLFNYDGPLRSSALRGLGAYANIF
ALESFMDELAETSDMDPFTFRINNLKDERAIAVLEELKSKTNWNAMGRSGNEGYGIAFAK
YKNTAAYFAVMAEVEKDPERKSFKLTRMVGVIEAGQCINPDGIINQTEGGMIQSASWTLI
EAVKYDEHGFLSKDWNSYPILRTNDVPEVEVYVINRPELPPLGAGEAAQGPVAAAIANAV
FDCTGTRIRELPITAEKINW
>K1LHV6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MTLSKTSLNRRSFLKVSALAGGGLFLSVGWLAGCKPGSKEAALGMPEEWFRINGFIRIGE
NGLITIMSPNPEGGQNVKTGMPMIVAEELDADWSKVVVEQAPLDTDNFTRQFIGGSQAIR
MGWNVLRQAGATARQLLVNAAAQTWDVPANEITTESGYVIHTASRKKAHYGEMASLAATL
PLPENVQLKDRKDYKIIGTARKNVDAKKIVTGKPLFGVDYKKEGMLYAMIIHPPAHGLRL
KSFDASEATGMPGIKDVFQVKSHQDDYERTFFDTTSFTDTVAIVGNSTWEVMNAKKAVKV
EWEEFSTYEESRDWNGRKEKRTIPAGLEDEQEQLRKMGIAAKNARTVRKDGNPEDAFRSA
AKVIERTYNGPFLAHNCMEPMNFFAHVNGDKVECAGPLQKPELTEQALSSRLGIPIENIH
IDMTRLGGGYGRRSYAHWLIEAAVISQKVNAPIKLIYSREDDMTGGIYRPMYQATYRAAL
DKDNNLIGFHVNAGGLVEPPLYADRFPAGSVENYLAEEWTVASNITVGSFRAPRSNFIAA
AEQSFLDEIAEAIGKDPIDFRLELLKKAKENPIGQNNDYDPVRYAGVLELVKEKSNWEQV
PAGISRGVSAYFCHNSYAAQVVDLKIENGQVKVEKVVQAVDCGLIINPDAARNLCEGCVV
DGIGTAMYGELKFNQGAPDRSNFDRYRMIRMSEAPKVIETYFVESQIEPTGLGEPGYPPV
FAALANALYQATGKRLYQQPFAPQLS
>A0A3G8CAI7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R4-34-07|TrEMBL
MELRINQQAYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAALVGREITTIEAIEADDVGKRVVAAWVERQVAQCGYCQSGQVMAATALLKHTPAPSKE
QINAAMINLCRCGTYNAIYAAMDDLAAGKETA
>A0A0R2ZCG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MTSQPITVTLEVNGQTSEVSAMADTPLLLVLRNDLQLNGPKYGCGLGECGACTVIIDGVA
ARSCVFPLSGASGRRIVTLEGLGTRQAPHPVQQAFIDEQAAQCGYCLNGMIMTAKALLDR
NPKPSETQVRNELSGNLCRCGTHIEILRAVLRAARLMNVDG
>A0A0F7YAC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. CCOS 191|TrEMBL
MELRINQQTYQVEADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIEADAVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPKPSTE
QIDAAMVNLCRCGTYNAIHAAVHELAQGENA
>A0A0C4YJG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MRTITINGKPQKIDLPDDAPLLWAVRDHLGLTGTKFGCGMALCGACTMHLDGQPIRSCVT
PISAVAGKKITTIEGLSADKIGQALQAAWEEFGVPQCGYCQAGQLMSATALLHTNPHPSE
EDIDGAMSGNICRCGTYTRIRAAIQHVARSSVAAKPSAQPTGKRSAQ
>A0A0C4YJ05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MKFNLNGRQVTFDGDVETPLLWVIREQFKLTGTKFGCGIGMCGACTVHLDGVPVRSCSVP
VKHVTGRTVTSIEGLSKNRSHPIQLAWIEKDVPQCGYCQSGMIMSAAALLKNYPKPTDEQ
IDQAMTNLCRCATYHRIREAIHDAASKK
>A0A0C4Y5R1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MTRELNLIDATPASGGRRRFLQAGAALAGGLLLEIGSAGQFIRNAAAAPITDSAAGNFAP
NAWVRVTPDNRVLLVVHKYDSGTGVKNALGLMLAEELDADWATVQVIQPDDPLAKAYLHP
LWGMHATGGSTSVALEWNTLRRAGAAARAMLVACAAQRWAVEPAACKTAAGAVIHVASGQ
RLTYGELAEGAARLPVPLEVTLKRPDEFVLIGKERSSYRVADKLTGRARYAIDIKLPDML
SAIVVHAPVVNARVVSFNAAEVKALPGVRDVFATEIPETIAHFRPDAPAARPINGASQPG
VAIVADHFWAAQRARQALKVVWGDSAMKDFSAQAAIRAMAARVDEPGKKSKVKGDADAAF
QGAAKVVEAVYTMPYKAHAQMEPLSIVAWVRPDAVEYWGGVQVPSRCAQAAETIAGVSRD
NVKIHLTEAGGSFGAREGLHIILEATYIAKRMGRPVKLLYSREDDMHALYYQSASVHKAR
AALDAAGNVQAFSLRAVVPSIKEPDDPGFLAKVPVDPSCTEGMRDDFYYQVPALDLAWVR
HEPGLPVWWWRAVSYVPNIFAIESLIDEAAHASAQDPVALRRKLLHGKPEHVAVLDRAAA
LAGWKAGAKPGKGGNGRGLGVATYEGYKSYIAIVADVSVRNGAITVHKITCVVDCGLAVD
PGSVRQQLAGGIYWGMSTALMNAVHIENGGVKQSNFHDYPVVRMSDAPALEIVVMPPSGR
QPGGVGELSNPPVVPAIGNAIFAATGKRLRATPFALAQASV
>A0A0P1ESA4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shimia marina|TrEMBL
MQLIVDGKTHEVDVEDDMPLLWVLRDELGIKGVKYGCGVAACGACTVHVDGVAVRSCQTV
LSDVEGEITTIEGLGQPEALHAVQEAWIEHQVAQCGYCQSGQIMQAASLLAETPNPSDAE
IDEAMSGNLCRCGTYPRIRAAVKTAATKIQGA
>A0A6A7SH80|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|wastewater metagenome|TrEMBL
MQQPYSQPFSPSRRRLLKGAGAAGVGLVIGFHWGLGGPRAMAAETESGGWAPNAFVRIAP
DDTVTVISKHIEFGQGSYTGVATVLAEELDADWSRVQVAPAPANAELYGNALLGGMQGTG
GSTAMASSWDQLRQAGATARAMLVAAAAERWGVPASELSVAQGVVRHAGSGREARFGELA
EAAGRREAPKEVRLKDPSSFRLIGHRVPRVDASEKSNGEAQFTLDIYLPDMLTAVMLRPP
LFGATLRSLDDSEARKVRGVVDVVRTPRGVAVLAEGFWAAKKGRDALKAEWDDSAAEKRG
TEALYEDFAALAREPGATAEAHGDAQAAIDGGTRVIEAEYRFPYLAHAPMEPLDAVIRAT
GDGYELWAGSQIPTIDQGVVAKTLGVPAEKVAVHTQFAGGSFGRRATPNGDVAMEVAGIL
KATDGRRPVKLVWTREDDIQGGRYRPLFVHRLRAALDDDGRPVAWQHRLAGQSIMKEMGG
LRDNGVDPVSVEGAEDLPYSFEHFAVEGHNPEAGVPVLWWRSVGHTHTAFSTETFMDELA
HAAGEDPVAFRLARLGDHDRHRGVLELAADRAGWGKPVPEGRARGVAVHKSFNSYVAQVV
EVSKGENGLPRVHRVVCAVDCGVAINPHNIEAQMQSGIGYGLGAALYDEVVLEDGRPKQA
NFDTYLPTRMTDMPEVEVHIVDSDAAPTGVGEPGTPPVAPAVANAWFALTGERVRRLPFR
RNG
>A0A6A7SJY4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|wastewater metagenome|TrEMBL
MESLWPGSVTDGLDPLAVEGAVALPYAIPRAAVGYAMRDVGVPVGMWRSVGHSYNAFAVE
CFVDELAGRAGIDPVDYRLRLLGDAPRLAAVVELAAARAGWGSPRAGRAQGIAAHACFGS
YVAQVAEVSRDDDGGVRVHRVVCAVDCGIAVHPDTVAAQMEGAIAFALTATLYSRITRGT
NGTVESNFHDFPLLRFSRMPRVDTHIVPSREAPGGVGEPGVPPLAPAVANAVSALTGQRL
RELPLRLNSDA
>A0A5P9ELS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter sp. THAF39|TrEMBL
MTMNRRDFLKVSTGASGSLILAVSVPGCASVQTGYQPETGEWKPDIWLELTRDDEIIFTL
ARVEMGQGTYTGLTTLVAEELDVEPGRIKVKFAPVAPEYRNPLFGLQLTGGSTSLASSWV
PLRVAGAQARQMLIMAAARVWEVDADQCTTQDGRVVHPNGVDSLRYGQLVELADREVIRG
NVPLKPRSEWKYIGRKGGKLDARAKATGTAVYGMDVELPGMVYAVMTRSPRYGGKASSFN
RDEVIGMPGVTDAFITERGVALVAQRYWQARKAQQKLRVEWDLSDALDTNTEAVFDSYRQ
AASKDPGVKERSEGNVEKAAERAKQVVEAEYEQPYLAHATMEPMNATAWYRDGGMDVWAP
TQAPDLGRIAAARHTDLSPGKITIHTTFLGGGFGRRLTQDYIEEAAAVAYQLKVPVKLIW
SREEDTRHGFLRPAMLHRMKGSLNDGELTGWHHQIVGPQVLDWYVRNAAPAQYPWAPKFL
YDTLGRVGLMAEGIATPKDISAIEGAIEYPYQVPNVSVRHTHTDPGVPITWWRSVGYSHN
GFAVETFMDELAHESGEDPLQFRMKMLDAEPRHREVLERAARLAGWGEAAPEGRARGLAL
FKSFGTYVAQVVEAGIENGEIRVYKVVCSVDCGQVVNPRIVEDQIEGGILFGLTAALYGE
INFDNGEIRQSNFHDYRLMQMHQTPEVVVDIVDSEADPTGVGEPGVPPVIPALGNALFAL
TGKRQRRLPLTV
>A0A3B0RVG7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MQITINGKQITVPENRQDVTLLGFLRDSVGLKGAKFGCGAGLCGACTVHVDGLAKRSCQL
TTADVVGSKIVTIEGLAQTTGDANLHPVQKAWIEVGVPQCGYCQAGQIMSASALLARNPD
PSETEIRTEMSGNLCRCGTYERIRQAINLAARESGQ
>A0A0P1IS84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cognatishimia activa|TrEMBL
MGRARTIGRRSFLIGSAAIAGGVAFGVYTARTPFANPNLKELQQGTASFNPWVIVDSDKV
TLIATHADKGQGIFSAQAALIAEELDIDLDQVEVSFGMPDKAYFNGAAIDAMAGFPLYDN
SPTAERVRGFLGGVVKLALPMMATGGSSAIPDTYEKLRHAGACARETLKLAASQQSGVPV
GQLKTERGSVILPDGTALSYTSLAGIAATIEPVEKVALRDPKDWKLAGKPMNRVDMVQKC
TGTLDYGIDFETEDMVYAAIKVNPRQGGAMNSYDASAAKEMKGVKDVLEITGGVAVIADN
TWRAIQASNAIEFDWGEAPYPAEQADHWKVLEETFTEESLNAEARVEGDVDAAEGEEVTG
EYRSPYIAHAPLEPLNATILVTDERVDIWTGHQIQMFVESIVAGITGVDQENVHLHNKFM
GGSFGHRLEFDFIKQAAEIANQMRGTPVKMTYSREEDFAHDFPRHITMGRGVAKHKDGKV
TSLDVQIAGQSVMRSQMGRMGMSLPGPDAQLHEGAWDAPNFNLPNLRVRSYLTEALAPVS
SWRAVGAGPNVFIYETLLDEAIHAAGADPLEERIRLMGHDVSVKVLEKVGEISNWNGANL
GENRGRGVAYGFSFGVPVATVVEVTNTDRGIKLDGVWVAADVGKVIDPGNLENLGQGGTV
WGLGHAINCEITYSDGMAEQSNYHAHEGMRIWQCPPITFAALENSPKVRGFGEPPVPPSA
PALGNAIFAATGQRIREMPFNKHIDFV
>A0A7W6DBY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MIENLVSRRNFLRGTALATAGLVLAVQLPGNTRRASAAVGEQSKFIPNAFVKIDTDGIAL
IMPHTEVGQGIYTSSAMLMAEELEVDLDQVRVEAAPPDLKKYMDPILFDQATGGSTSTQS
DWVRLREAGASARIMLVGAAAERWGVSADDCRVEKGIIRHDPSSRSLSYLDVAPDAATRE
APKQVPLKDPSQFRLIGTRAKRLDTPAKVDGSLVYGIDTRLPGMAYATLAIAPVKGGRIA
SMNEAAARAVKGVRDVVRTEDSVAVIGEHMWAAKLGVDALELSWESGPNASVSTQAIVND
MHEASLKPGVVVRDDKGAAEAIRKAKTKLDAIYRSPFLSHSPLEPMNCTLHIKDDRAELW
VGTQVPVRAQKAVAEATGLPPEKVTVNNQLMGGAFGRRLDIDTIEQAAKLLRNIRYPVKL
VWTREQDLTHDFFRPYYYDRVSAGLDDAGRLVGRTHRVTGSSVMARWAPPAFVNGIDPDS
LDCAAETPYDETSVFADYVRHEPEGLTTAWWRGVGATHNLFVIESFVDEMAYAIGQDPVD
FRRKMLTRNPRALAVLELAAEKAGWKDKLPQGRGRGVNLQFAFNTYLAHILEIEVVPGKE
VKLLRSVLAVDCGIVINPDTVRAQMEGGVLFGLGTAMFNEVTFTDGAVDQSNFDNYRILR
INEAPKVEVYQVKSLEKPGGVGEAGTAAAAGALANAIFSATGKRIRSLPLSEAAV
>A0A6J4I6Y3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Chloroflexia bacterium|TrEMBL
MSRPGANETRPAATGQSGTPGRAADIEPEATVIGDWLHIDADGSVVVYTGKTEVGQDIRT
SLAQAVADELRLQVAAISLVMADTDRTPYDMGTVGSRTTPVMATTLRRVAAATRELLVAV
AAERWQVARAELQIAAGQVAHPPTGRTIGYGQLTGGQRMNQEYSEDTPITSASQWAVAGT
SVPRVDGRALVTGRIRYTADLRRPGMHWGAVLRPAAHAATLRHIDTQAAAALPGVTVVHD
GSFVGVTAPTRAAARAALAAIEAEWIVPRQIDTVELFEYLREHPLPPDDPAGSGRAAVDE
AGSLEAGWNAAEQVVAGTYTVAYIAHVPLEPRAAVAEWQDGRLTVWTGTQRPFGVRSELA
HIFDLPESAIRVIVPPTGGTYGGKHLGDAAIEAARLARGAGRPVKLIWTREEEFSWAYFR
PAGVIDVRGGVRGDGTLTAWEQATFNAGSAALRTPYAVANQRSAFHPTRAPLRQGSYRAL
AATANHFARESLMDELAHALRMDPLAFRLRNLQDARLRAVFEAAAARLGWGKALPEGHGA
GIAGGTEKGSYVATCVEVMVDASAGTVQVVRVVQAFECGAIVNPDGLQNQVVGAIIQGLG
GALWEAIDFADGRVLTRRLADYRVPRFDDIPPIEVVLLDRKDLPSAGGSETPIIGIAPAI
ANAVFAACGMRLRSLPLLPALRAGARPVT
>A0A109B8G0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. WDL1|TrEMBL
MIRRAEQPRTRSDFLHAPDVLLVVRETPPPPPAANGQPPVVFGNPAEGPEILLALWSDGS
ATALNGHVDLGTGIRTALAQVVAEELDLPLTQVHMVLGDTARAPNQGATIASASLQIHAA
PLRLAAAQARAWLLEQASERFGVQPSLLEVREGRIHAGEDPAFSVPFGELVTGTRTVLQL
DGAARLKDPRDYRLVGTAVPRVDIPAKLAGETVFVHDMRVPGMLHGRVVRPPYAGADHGD
FIGNTLESVDESSIAHIPGLRAVVVIRDFVGIVAEREEHAEQALRELRVRWKPWPGLPAL
DDLEGAIRANPATQRLLVDEGRVDEALANAAQPMPRTYVWPYQMHASIGPSCALADWQPE
GEPGVQLRVWAGSQNPHVLRADLAKLMGVEDVAVDVVRMEAAGCYGRNGADDVAADAALL
ARAAGAPVRVQLTREQEHAWEPKGAAQLMQVNGGLDAEGGVAAYDFETSYPSNGAPTLAL
LLTRTVEPVAQAFEMGDRTARPPYAYENLRVKVNDMAPIVRASWLRGVSALPSSFAHESY
VDELATAAGVDPVAFRLRHLRDPRAAELVRETAQKAGWRMRTGPQENVDGGLGPGGDVLF
GQGFAYARYVHSKWPGFGAAWSAWVADVEVHKTTGEVHVRRVVVGHDAGLMVNPAGVEHQ
IHGNVIQTTSRALKERVQFAPAAEPSGGETLPGVLPAGVVASREWGGYPILSFREVPVIE
VVHMQRPGEPPLGAGESSSVPGTAAIANAIFDATGVRFRAPPFTPEVVRAALNPLASPER
RKAGELLYPQPGEGGGGGTQRVDGEAPAPPSQPSRKGGRSRTDAPRPKARGLWATATAVV
IGGLGLMAGLLGWRSAIAPVTLSAPVYSQATIDRGRTLAALGDCAVCHTAPGGVPNAGGR
AMETPFGTLYTTNLTPDPDTGLGRWSFSAFQRAMREGISRDGHHLYPAFPYTAFAKTSDD
DLQALYAYFMSLPAVQAPTPEPELKFPFSLRPLMAGWNALFHDPAPLQPVAQQSAEWNRG
AYLVNGLGHCGACHTPRNALGAEQGGSAYLSGAMVEGWEAPALTGAASKSAVPWNAESLY
RYLRNGHSPQHGTAGGPMAEVVRELAAVPDADIRAMASYLASFNAEASEAEARAQAQRAV
AAAAARQGQLLGPAQRLFDGACAACHHDGNGPTLLGANVPLALNSNLTSARPDNLLRTIL
DGVREPATREIGFMPAFRDALSDAQVAELAGYMRARFAPQEPAWKDLASEVARVRRGE
>A0A654DFQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. 8AM|TrEMBL
MTRLTVNNEAVEYRLAPDTPLLWALRDASNLTGTKYGCGTGSCGACTVDVDGKAVRSCQV
ALRQVEGTFVTTIEGLSRERSHPVQLALIAANVPQCGYCIPGITMAAAALLKRDPMPSDE
AISAAITNICRCGIYPRLVEAIQRAGRAIRGDERLPAAPRPGIDPAEAARHVPALDPPSG
R
>A0A7W5ADE4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes campanulatus|TrEMBL
MTITRRGFLGAALVVAVPAPAQDQQIRTVFVRVDARGRITATVPKPDTGQGVRTMAAVLV
AEELAVEVADVTLEQAPGDPATYGPQAVANSTSSRQMAEPLRTAAATARCLLIAAAAARW
QVPVEECTARQGRVRHPAHAALPYRSLVPAAAALDPATVAVTLTPPERWRLIGRTRAGRS
DARDIVTGRARYGAESAPAGSLVAVVARPPWIGAIPDTVDDSATLAVPGVVAVVRLAAPG
AGQGGVAVVADRTATALRGRELLKVAWTGGTPAADSRVWLDALEAALAAVPGDPAVQRVY
RLPLLAHAPMEPMNATAHVTATGVKVWAPIQDPGGVRTQLARALALPEAQIDVRPTLAGG
GFGRRIETDAVFEAVACSRAAGQPVSVRWTRDDDTRHDSYRPMSVHRLSATLGADGLPVG
RAHQVVTWPLSVSPPFASPVVVKASGDHFPYAVPGDVTVTLRPAPLRTGFWRGVYAGQFG
YAEECFLSEIAQAGGHDQVEFRRRLLPAGSRLRAVLDAAARSHPDPDGVACHLDYGSAVA
VLATVDAAARRVRKVTAAVDVGVPVHPSGVRAQVEGAVLDAVSTVLGAQITVRDGAVVQS
SFRDYAWARITDCPAIEVVLVGSDAPIGGLGELAYPPAAAAIASAFAAYGGPVTGMPYGV
PVG
>A0A653T2Q3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alteromonas sp. 38|TrEMBL
MITFTVNGETREFAGDPTTPVLWYLRDELHLTGPKFGCGMAQCGACTVHINGVAQRSCVL
PVSAISGSKITTIEGLSKDGEHPVQQAWVEHKVPQCGYCQCGQMMQAASLLASNPTPSDE
EIVQGMSGNICRCGTYPRIHKAIKSAAKTMAGVEYYVPESAGEEA
>A0A654BNW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. AX6|TrEMBL
MAATDEKKTIRINRRSLLVAGGAGAGLLVAWAVWPRSYGVNLSAAPGETIFGAWLKIGEN
GQVTIAVPQAEAGQGVYTALPQIVAEELGADWRTVAVEAAPINPLYANTLAADVLFEDAL
GGIPDAIRRGHAERAAWMLTAGSTSIRMFEPKLREAGAAARTLLCKAAAARWGVDWQACA
TSEGFVVHDDKRLRFAELAAEAAQESLPDLLPLRDAGAAAPEGAPLTRLDAPAKVDGSAN
FAGDIRLPNMVFAAIRQAPPGDARLVGVDRAAADGVRGVMHIVENPRWVAAIADNWWAAE
QALDALRPRFEVRGGPTSASIDAALTTALDGEGQRMASAGELAEHFSGAKVVAAEYRSGL
ALHAPLEPTTATAEWRGGRLSIWAPTQAPGLARSAAARVLGIDETAVVVHPMQIGGSFGA
RLETLVIEQVAVLARKLERPVQLTWSRAEDCLHDRYRPAAAARMSARLAPNGTVSGWFAR
IAAPQSGRELSQRLLSGDAAVALAQKLPGGGGDRTAVAGAEPIYGIPHYAVDHHPAALGV
PTGYWRSGAHAYTVFFTESFLDELAREANVEPLSFRIAMLGGQPRLARCLSAVASLGGWQ
GGLPGTAQGIAAHSFRGSHIALMAEARREGGRVVVDRLVAAVDCGRLINPDLVEQQIEGG
LLYGMAAALGASTGFTDGLADVRNFRSMNLARLGQTPEISVELIRSDADPGGASEVAVPV
VGPAIANALFAATGRRSRRLPLQEPTL
>A0A1I9ZEN8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardia seriolae|TrEMBL
MTVEPSKRTGTQPAEFIGPTRTMATLRVNGHEHYPVLEPRTSLLDALREHLHLTGTKKGC
DQGGCGACTVWIDNRRVLSCLTLALAAEGREITTIEGIADGDRLHPVQQAFLETDGFQCG
YCTPGQIMSAIKCIKEGHAESESEIAEWMSGNICRCAAYQNIRDAVCQGRDGMRHKEGGL
P
>A0A1S7SJV8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Agrobacterium sp. NCPPB 925|TrEMBL
MNEHFREWPTKGEMSSGAPINLSRRGFMLASAGLTAGALVIGFGIPVQSTRAQEAAGKVA
PGTRVPAFLEIRPDNTARLLSPFVEGGQGIFTGMAQIVGEELDLDPASFTVENAPAGPDY
QIIFGMRLTGGSNSTRLSYDTMRRLGASARLMILQASATRLDVPLDELTTEPGRVVHAAT
GRSFSYGDIARHAFDLPIPAADHVTLKDRSQFRWIGKSIPRLDVFDKTVGRAVYAIDCRV
EGMLQAAVQHAPRLGMSAGTIFNEDAVKAMRGVLSVHRLPGAVAVVAERWWTAKRAAEAL
QVDWQEADGISAVEGGRIMPIDFSTKAFADRLVHEPGDGRDAETEGDPAGVLASAKKIVS
ATYQSQYLNHAQLEPPSTLARFSSDGTLDVWMPNQSPEVFQADIAKSTGLDLAKINIHSP
LLGGFFGRHFLCVAANPYKQAIQLARETGRPIKLIWSREEEFLRDTLRPMAAVRFRAALD
DSGMPMAVEAVSVSEGPTEGIRGHNPEKIDKTAVEGLTGKSYLIPNRRIAQIYVQNPAMV
SYWRGVGHSMNDFFYECFLDEMADAGGKDPYDLRLQLLRNNARLTNLLEAVSDMSGGWKR
GPFTAEDGSRRARGIGMASPFGSHTAAIAEVSIQSGEVVVHDLWQAIDPGSIINPGIIEA
QINSAVALGLSQVLFEEAVYEKGRPVARNYDLYRVLSPDQMPRVHTKIIESGEKMGGIGE
PGLPAVPPAVANAVSTLTGKRLRSMPLSHYRFET
>A0A2N7R6T3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. AD80|TrEMBL
MYNITVNGQPFSTEVDADTPLLWVLRDEVNLKGTKFGCGIGMCGACTVHVDGRAIRSCIT
PIAAVAGSAITTIEGLSPDGTHPLQQAWIATQAPQCGYCQSGQIMQAATLLKDYPQPTDA
NIDAVMSGNLCRCMAYVRIRNAIKLAAGMPEAPHA
>A0A6H2H7W7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polaromonas vacuolata|TrEMBL
MQDNHKSTGLNRRNFLASTGAVSGSLMLGFAVGMPLISQAAGTASASHAPNAWVRITDDN
VITLLTARSEMGQGVYTAMPMLIAEELQVDIRKIKVEVAPANKVYTNALLGAQITGGSTS
TRDAWVPLRTAGAQVRMMLISAAAAQWKVDASTLRAEDGMVLGPKGQKASYGSLAAAASK
LPVPTKVVLKDPKDFTLIGKATPRLDTPSKVNGTAEFGIDVKLPGMVYASLQQCAVIGGK
VKSFDAAKAKTMPGVIAVVQIPDGIAVVAESYWQAYKARQAVTIVWDEGALVNTTHENML
AGIRNASITGKALSIVAPKGDVSEAMKGATKIIKAEYVSQLLAHATMEPQNFTADFKNGK
CMLIGPTQFQTGAVGGVAAALGIKPEDVTVKTTFLGGGFGRRLEVDFIVQAAQISKAVGR
PVKMLWSREDDTAHDFYRPMAVNQLLAAIGPDGKPVAFDFRLTSQSITQRAFGLPKDTVD
DFMTEAAVVGYDIPNTRYDLVIHHTGLRAGYWRSVSHAINAFANESFVDEMAAAAGQDPY
AFRMSMLAKQPRYAHVLKLAAEKAGWGTAAPAGRTRGMALMSGYNSYMAQIVEISVKDNR
VTVHKVTVVADVGMMINPDTVLAQIQSSIIFGMTAALNNEITLAAGRVQQTNFGDYPVPR
MNETPEMDITLVTSTEAPGGIGEPVTALVAPAIANALFTATGKRVRQLPIHHYIDKA
>A0A839XSM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella sediminis|TrEMBL
MPKHTFKVNGETVTVDVEDNVRTLWVLRDILGIRGPKYGCGINVCKACTSHVNGKAFNPC
AVPVDQLDENDEITTIEGLADGDQLHPMQQAWIDHDVAQCGYCQPGQIMAAIDLVRRVRA
EGRSITEDDLDTLRNICRCGTYPRIRQAIKAAAAKM
>A0A6H2H8N2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polaromonas vacuolata|TrEMBL
MTTQLNLNGRLLNVKAETDTPLLWVIRDEIGMTGTKFGCGVALCGACTVHMDGVPIRSCV
TPLSVALGKKITTIESLSQDNSHPLQVAWIKHDVPQCGYCQSGQLMSAAALLSSNKNPSD
AEIDSAMSGNICRCGTYPRIKAAIKDAASTMRKA
>A0A7W5NKE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WP4_3_2|TrEMBL
MSQGLLDAGRSAERAAASSGVSRRSFLKMSAAAGGGLLLGFSFDAGAQGDSAARKSVVGG
DGNEAPQDGVFEPNAFVQIDRTGKVTLIIPKVEMGQGVYTSIPMLIAEELEVPLDSVTLD
HAPPDAKLFTDPLLGGQLTGGSTSIRYAWEPMRRAGATARVALIAAAAQQWSVDAGECHA
KNGEVLHDASGRRASYGQLVDAAAKLPAPQNVTLKNPKDFTLIGKPTKRLDSPEKVDGSA
LFGLDVRVPNMVYAAIVNCPVFGGTLARVDDTHAKQIPGVTQIVKIDNGVAVIGAHTWAA
KRGAAALVIEWNEGATANLSMRQIVGDLANAAQQQPGAVARKDGDVQQAFGGAKTRVDAV
YQQPFLAHATMEPINCTVHVRADACEIWVGTQVPTRAIDAGVAVTGLKPEQIVLHNHLLG
GGFGRRLEVDAITQALKVGKQVNAPVKVFWTREEDIQHDMYRPFYYDRISAGLDANGKPV
AWQHRIVGSSIMARFAPPAFKNGIDPDAVEVAADLPYDLPNQLIEYVRQEPHTVPTAFWR
GVGPTRGTFVVESFIDECAAAAKTDPVQYRRNLLGKSPRALGVLDVATRAANWGPPMPKG
QGRGVSVMHAFGSFFAMVADVSVTNGEVRVNRVVAAVDCGMVVNPTTIEAQVQGGIVFGI
SAALYSEITIERGRVQQRNFTDYRILRIDEAPVIEVHIVPSGEAPGGIGEPGTAALAPAV
TNAIYAATGQRLRHLPVGRQLMNTQSA
>A0A653LSA4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Flavobacterium sp. 9R|TrEMBL
MVTLDINGKKYNLDVAPEMPLLWAIRDIIGLTGTKFGCGIGACGACKILINNEATYSCLT
PVSDAKGKKIITIEGSSPNLQLLQEAWAEYNVPQCGYCQPGQLITATSLLNSNPSPSETE
IDDAMSGNLCRCGTYQRIKNAIQHTVELKKQGK
>A0A0U5F6V2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ghanensis|TrEMBL
MRITGGSMSVRNGYPAMRRLGALGREMLLQAGAQHLGVPVSELTTQPGQVVHVASGRTVN
YGDLAHVAMDLPVPGPASVKLRDPSQFRWIGKSVKRLDIYEKSTGKVDYAIDVRVDGMLH
AAVQHAPRLGMTVGSIRNEEQVRQMKGVHSVHRLPGAVAVVAERWWHARRGVEALLVNWV
EAEPGAASDIRVMPADFSTEEFRKHLATVSGKEENAETRGDVTRGLKNAHTIVEATYFSQ
YVNHGQLEPPSALARYNPDGTLDVWLPNQAPDMFRADMARRTGMDAEKITIHSPLLGGFF
GRHFLYDHGSPYPQAIALAKATGRPIKLIWTREEEFLRDALRPMAAVRFRAGLDETGRPV
ALDVVSATEGATEGLGTKRGKDLDPTALEGLTNKAYDIPDRRIAQLFVRNPATLGYWRSV
GNSMNDFLYETFLDELADKGHQDPYELRLHLLRDNRRLTTLLKAVADLSGGWKRGPFTAA
DGSRRARGIGMASPFGSEAAAIAEVSLENGRVRVHEVWVLIFTEN
>A0A653LTB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Flavobacterium sp. 9R|TrEMBL
MKAIQNYSRRDFVKTIGLASGGLLLAANSSLFASESTSTIETFNPNLFVYLQTDGTLTLI
ASRSEMGNGVRTSLPSIIADEMEADWSKVVVQQALGDTKYGDQNTDGSRSILYLYDTMRK
MGATAKALLITAAAQKWNVPETECIAQHHFIVHSSGKKLGFGELAATAKTLELPKNVTLK
NPKDFKYIGKTLKSVDVANYANGSAVFGIDKRIPNMKFVAIARCPVTFGTVKSFDKKAAL
KIRGVIDVIEIPRIAKPFGPLGGVAVIASNTWAAFEGKKALTIEWNYGPNATYSSADYQK
TISDGLLQPAKVAKSIGDVDQAFAKAHQIVESTIQLPLLAHAPMEVPNAVAWVKGDSCEV
WAPTQDPQTARKEVADYLKIPLDKVSVNITFLGGGFGRKSKPDYIVEAVMVSKVINAPVQ
VVWTREDEIKHGYYHTESAQYLKAALDAQGNVTAWLHRFALPSIMSTFVPGTEYPAEWEA
GSATDIPLDVPNFKVETGKAPAHVRIGWMRSVINIPHGFSVNVFANELAYAAKKDPLEFR
LNLIGPDRIENTQDAIKYNTARMKHVLRQAAKNANYGKALPQGHAFGIAVQYSFYSYVAS
VVEVSFINNKVKVHNVYTVIDCGTVINRDTVKAQLEGAAIFGMSLTYYGKITAKDGAIEQ
NSFSDYPLIRMNEAPKIHVEIVESTENPTGVGEPGVPVIAPAIVNALFQLTGKKYYNLPL
IDYEIVG
>G9AEK4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium fredii (strain HH103)|TrEMBL
MLPKLMQSLTLPAARVEASRRQFLIGALATGTGLAIGFHLLSASPAAASETATPSGAHAF
SPYVTIDGDGKVTVLSSQFEMGQGSYNGIATLVAEELDADWSAIDVKGATGNLQAYGNIA
FGGAMQGTGGSTSMVTSWERYRKAGAAARAMLVAAAASEWGVEAAEITVENGLLAHPSGK
SGGFGVFAAKAATLPVPVEVKLKQPSDWKLIGNSELKRFDSARKANGTEQYTIDVKLPGL
LTAVMIHAPLFGAKVKSFDASAARAIKGVVDVVETPRGIAVVGEHMWAAIKGREAVTVEW
DETGAEKRGTQQIMSMYRDLVNKPAVAVARKDGDAEAEFAKAAKVIEASFEFPYLAHAAM
EPLNAVARMNDDGTLEVWGGHQFTDVYQKLAGDVAGVAPEKVRLHVMKTGGSFGRRAVFD
GDVVVEAVHVAKAIGFRAPVKLQWTREDDMRGGRYRPAYVHSLKAGIDGGGKLVAWTDHI
VGQSIVAKTAFEGMVKNGVDPTSVEGASNLPYAIPNQTVGLTSTEVGVPVLWWRSVGSTH
TAFAAETFLDEVAEAAGRDPVEFRLSMLEPDSRHATVLKLAAEKAGWQKPLPEGRFRGVA
VAESFGSVVAEIAEVSTDGNGQIKVERVVAAVDCGLAVNPDQVRAQVEGGIGFGLSAILG
EEISLTDGQVDQGNFDLYTPLRIDAMPAVEVHIVASANPPSGIGEPGVPPIGPAVANAAY
KALGKRIRVMPFAKSLNA
>S7WQS0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cyclobacterium qasimii M12-11B|TrEMBL
MNKGLKSNRRDFLKIAATTGGGLLIGFNWSACDSPKMKVISDQEIYDRAVNFNSFLSISP
SNHVVIFSPNPELGQNIKTSFPMIVAEELDVDWANVRVQQAFLDTEKYDRQVTGGSGAMP
HSWQRLRQAGATARQMLMEAAAKRLNVPITELKTDKGNVIHGSKKLNYGELANEAAALTV
PEEVKLKEVKDFKIIGTAVKNVENDAMFTGQPLYGLDVYRDGMLHAMIQRAPFGMKLKSV
DADEAKKVNGVKDVVTFKDNVAVVGTGTWPLMKARKLLKIAYEPIDKALESTAFHNSKFD
EMLNSGAAEVKRKDGDVNAAFKNAARIIKSEYQCPFLSHSPMEPMNFFANVKEDSVELIG
PTQTPDRARNAAAEICGIAPEKVSVELTRLGGGFGRRLRADFVEEAVELSKMLKAPVKLT
WTREDDITGGAYRPAVKYRFEAALNSKDELVGYKLTGVGMNSGNSTRENNFPAGAIENLE
IKSMAFDSPITTNAWRAPITNFLAFAEQSFLDEVAEAMGKDPVAFRLELLDKAKANPVGE
IHYDIDRMRGVINTAVEKSGWGKKQGVSQGFSVYFSHRSYVAQVAEARIVDGKAILDKIY
AITDCGIVINPTGADQQVRGGMLDGMGHAMFANLTFTDGIADQKNFDTYRLIRMKEIPEI
ETHFIDNGIDPTGLGEPALPPTGGAVANAIYKASGQRLRNQPFSNEEGMKNLNLGNPA
>A0A240BZZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia ficaria|TrEMBL
MTISQVPLSRRRFIVGAGALVIGAYLPSTGALARTSAAAAPGAPALDANAFVQVGADGIV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDTSVYKNLSFGFQGTGGSSSV
ANAYEQMRRMGAMARALLVQAAAQSWKTSAQEITVQAGRIRHAASGREAGFGEFAALAAT
LPPPDPASLPLKDPANFTLIGKAGGLHRVDSLAKTNGSAQFSQDIHEPGMLTVTIKKSPR
FGGRVASFDASRALAVPGVVAVKQTDTGVAVYAKNTWAAIQGRDRLRVEWDDAQAERRNT
GEIYAEFRRVAQKTGVLAKSHGKPDEIFDKADRVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVRARYGCQIQTLDHKQLCDLFQLPPEKVQIDTILAGGSFGRRIDLGNPTLGPDLAADM
AAAAKAIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVGWTDTVVGHSWTLN
SAMTALVVNGLDLMMVEGASELPYTFEAFRCDAHIVPGKVPTTSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPREAGVLRAVAKAANWQGARVVDGRARGVGVAKAFDT
RVAQIAEVSIGEGGIPRVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSMALYGNITLKD
GVIEQSNFNDFRPLRIDEMPEIEVIIVPSSEKPTGVGELGVPTIAPAVGNALALLGRPRT
SLSLPLHQPNRDAGV
>A0A5E7LRR5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACVT
PATTVAHGQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A5E8H0N0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11)|TrEMBL
MLHLLQKPLEAPKPSRRTFLKMSAGAVGGLIIAAKMPNAAKAAADAGEFVQPFVHIRPDN
TVVVLSKHLDKGQGTANGLATLVADELDASHEQIVLELAPSNPQLYANSLFGVQGTGGST
AMPNAFMQYRQAGAAAKAMVVSAAAKEWDVPAGEITVSGGVVSHSSGKSATLGELAGLAA
NEDVPAEPALKTPDQWVYIGKSFPRKDVKNKTVGAPNTYTIDFNREGMLTATVARSPRFG
GTVKSFDAAEAKTVAGVVDIFQIPNGVAVVAESTWPAIKARDLLEIEWDDSAAETRSTDA
MMTELKDMTTKPGLKVREDGDVDAALEASAKVMEIDYDFPFLAHGAMEPLDIVGEFDGET
AQFWFGSQIPTIDHNVASTILGIPFEKVSINTLWAGGSFGRRAQGDAHPVSEISFLLKAM
REAGMEPRPVKIVWTREDDMAGGYYRPMSAHKIKVGLDGDGNVTAVKYNIAAKSIIKGTA
FEPMLMPNGVDHNMTEGASDTTYSFPMMNMDQAFQETPVPVLWWRSVGHTHTAYVMETMI
DRIAKETGKDPVALRLELLKDDPRKTNVLKLAAEKAGWDTPLPEGRHRGVAVHKSFGSYV
AEVVEISFREDGTVKVEKVTAAVDCGVPVNPDNIRAQVEGGIGYGLGAILRNQVTLSDGY
VEETNFDTYESLRISDMPEIAVHIVPSTDSPTGIGEPGTPPIGPAVANAIAAAKDEWITS
LPFTKAGLV
>A0A3S4N747|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLNLNGKDHQLDVTEDMPLLWAIRDVVGYTGTKFGCGMGLCGSCTIHIDGQATRSCIT
PVSLAQGRKVTTIDHLHTDKVGEVVQQAWLDIGVAQCGYCQGGQIMSATALLKSNPAPSD
EQIEAAMAGNICRCGTYNRIKTAIHNASAKLQEAKA
>A0A5E7T1J0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQNVTTIDNLHADPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E8H021|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11)|TrEMBL
MMTKANEALNISRRGFVKMAAGLSFAIGLGGVSAVRAAASTETSLDVNHWLTIRPDGTIS
IVFPSTEMGQSSYSTLPQILAEELDANWDDVVIEQLNADDRRFGNPLFGNVLYTAGSTGV
QAYFDPMRRAGAQARDVLLQIAARELGVSKAELRTGPSAVVAPDGTRLGYGELVARGAAG
TSVPEADAVTLKERSEFRIIGHDVPRRDVVAKSTGTAVFAIDVALPNIAYATVLRAPVEG
ERPLSINDAKARAVPGVLDVVALPDGVSVVAESLWSALGARSMLEVTWSEDAPARAFNSE
ETLRLYAEAAEDPEAEQAVWAENGNAPAAIVAANQTYSQLYLSDYAYHAQIEPMAAVASV
DADGQGAEVWAGTQTQSWTTRTVMDVLGIEQDKVRLNMMTMGGSFGRRTAFTQDYVRDAV
LSSKAVGRPVKVIWTREDDVKNGTFRPAAAQRLEAGLTADGKLDGWHHKVATPTVIGFFN
PVRWDAVKPNDVISMRGAESKFYGIKDFRADHIITPRQARLAPYRGIGAAYTSFAAEAFM
DELAEQAGRDPLDFRMDLVAENPRGRHLLEKVAEMSNWSNQDGRALGLSFAGYSSSMAAG
VAEIEVDQSTGDIAVKHFWAAVDAGLIVSPDNAHNQIEGGIIFGISMALREKIDIENGEV
VQNNYWDYEIARANQIPPIEIYMAEVDAPPVGVGEVGTPMVSAAIANAFHRATGRRLRHM
PFTPDRVSALLQS
>A0A5E7V6D5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDALAEDKPKQFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAQVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPIGECHAQLHKVIHKPSGRELGYG
ALAAAASALPVPARESLRLKQPSEFRYIGKEGSKAIDGADIVNGRAVFGADVHFDGMLYA
TIARPAVYGGKVKSVDDSAALKVPGVLKVLQIESRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQSPMEPMVAIARYKDGVCEAWAPSQAPQVTRERIAERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGEDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E7MCB7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATSALVLVASWGWQDAFAEEKEKKFGADGMPNGWIDD
PKVYISIAADGMVTVVCNRSEMGQGVRTSLTMVVADELDADWAMMKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVSECHAQLHKVVHQPSGRELGYG
ALAAAAGALAVPARDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAIYGADVHFDGMLYA
VIARPAVYGGTVKSVDSSAAMKVPGVIKVIQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNIDDAMKGATSTLEASYYLP
HLAQAPMEPMVAIARFKDGVCEAWAPSQAPQVTRERIGERLGIPFDKVTFNVTLLGGGFG
RKSKPDFVIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLDKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAIHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAKQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVSYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVVGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGQRIRNLPVRFQLQGWQKAQA
>C5APD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)|TrEMBL
MISLSINGHQHSIDVEPDTPLLFVLRDTIGLTGTKYGCGIGQCGACTVLIDGQAIRSCQM
PVESVGAQTVTTIEAIEADPVGARVVAAWVGIEVPQCGYCQSGQVMAATGLLKETPKPSE
DAIAAAMTNLCRCGTYNAIAAAVRQAAA
>C5APD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)|TrEMBL
MNDLTPHHRLGIAARPQSEPVRNLSRRGFLGIASGALLLGIDLSKEAVAQTRAEGPAAVA
AKPGTRVAAFLEIRPDGGVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFTVECAPPGP
DYAVVNGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAARLAVPQDSLTTDDGRVIHA
ASGRTLGYGEVAQAALALLPRDDVALKNPKDFRWIGRPVARLDMRDKATGRATYAIDIRL
DAMLHAAVQHAPHLGTEPRAVANEAEVRAMPGVHSVHRLPGAVAVLADSWWRARKGAEAL
QVTWSEPAPEGIATVSATFSSAAMLAALKGTTEPSLPAEQEGDPGAAFANAAKVIEAEYD
APYLAHAQLEPPSAVARFTADGSLDLWVPNQMPELFQQIAAKTAGLQPEQVRIHSPMLGG
FFGRHFAYGPANPFPQAILLAKATGRPVRVLWSREEEFGMDAVRPLSFARFKAALGPNGM
PVALQTTAVGEGPISRWFGALFTSPVDSSVVEGLDKKPYAIPNRRLDYVRVAHPVTIAFW
RSVGHSMNDYFYESFLDEIAAAGGRDPFDLRMALLANSPRHATLLRKVAELAGGWRRGPF
AAEDGTRRARGVSMASPFGSETATIAEVSLEDGEARVHDLWIAIDPGSVVNPAIVKRQVE
SAAALGLSSTLLEQVVYENGQRQARNFDTYPILDRTRMPRVHVAIVESGAPMGGIGEPGL
PGVPPAVVNAVAVLTGQRVRSLPLAKTRLSGV
>A0A6J5ESN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia solisilvae|TrEMBL
MFAINVNGQDQQVDATPEMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGQPVRSCVT
PVAAVGPRKVITIEAIGATPAGRKVQQAWLDLDVVQCGYCQSGQIMSAAALLAAHAAPSD
ADIDAAMAGNICRCGTYVRIRAAIKRAAQGA
>A0A0U5F423|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter senegalensis|TrEMBL
MELTINGVQHHINADPDTPLLWVLRDDLKMTGTKYGCGLAQCGACTVLINGNAVRSCVTP
VGELGAAQITTIEEIEQDDIGKRVVAAWIRHQVPQCGYCQSGQVMAATSLLKQTPHPTDD
DIRAVMVNLCRCGTYNAISAAIHDLAGEAAEEGAKQ
>A0A2W0CBZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paenibacillus illinoisensis|TrEMBL
MEMEYLMRVLIAGICGVLIGYERKNRMKEAGIRTHFVVAVGAALMMIVSKYGFQDQAGWA
NLSLDPSRIAAQVVSGVGFIGAGMIFTQRHTVRGLTTAAGIWATAGMGLAVGAGLYWTGA
GVTLLIVLAQMLLHRPTRWLVSARTETLTIRLEQEADSLKAILALLGQEKISVIGFRTEQ
QTSTGSAQETVLEFTVQMPGSFRGEQLIVLLQDVPHVRSVELK
>B9AZX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD1|TrEMBL
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTL
ALSSVGSARITTSEHLADDAVGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPSD
ADIDSAMAGNLCRCATYQRIRSAIHDAARALA
>A0A7Z1AEE6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Thiodiazotropha endolucinida|TrEMBL
MKSDWITNLSRRRFLAAGVATAAGLTLGIMPVTRADTRRSGPGFAGAAPADQAAFQPNAF
LRIGSDNQITVISKHLEMGQGTYTGLATLVAEELDAAWEQVRVEGAPADAKRYRNLYWGE
AQGTGGSTAIANSWMQMRKAGAAARHMLVEAAAKQWQVKADEIGVEAGRLTHAPSGRSAS
FGEMADAAAQQPVPQEVLLKEPDEFRLIGKRLPRKDSPEKTDGSALFTIDVQLLEMYTAV
VAHPPRFGAKVRSFDDKAARAIKGVKQVLQIPSGIAVVGDDFWSAKQGRDALQVEWDESE
AFKQSSSEILDSYRELADQPGTVARNEGDSETAMAKAAKVIEAEYSVPFLAHAPMEPMDC
VVRIDASGCEIWNGEQMNTGDQMAVAGLLGLQPEQVRIHMLYAGGSFGRRANPKADYVLE
AVHIAKTMPPGTPVKLIWTREDDMRAGYYRPLYLHKLKAGLDAENRPMVWQQRIVGQSIL
AGTPFESVMVKDGIDQTSVEGAANLPYALKHIHIDLHSPQLQVPVLWWRSVGSTHTAFAV
ECFLDELAAEAGKDPVAFRRALLAEHPRHLGVLNLAVEKAGWDEPLGRNRGRGVAVHESF
NSYVAQVAEVTVRRGVIYVDRVVIAVDCGVPVNPDVIEAQMQGGMGFGLAATLASELTLR
EGRVEQSNFHDYLTLRIDQMPEVEVYIVPSTEAPTGVGEPATPVIAPAVANAVFAATGQR
LRQLPLRPA
>A0A1W6KA67|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter salarius|TrEMBL
MINLTINGQLHELDVPDNMPLLWAIRDVVGMKGTKFGCGIAQCGACTVHLDGVATRSCIT
PVSAAQGEITTIEAMADDPVGSKVQQAWLDLGVAQCGYCQGGQIMNATALLKKTPEPETQ
EIIDAMAGNLCRCGTYNRILAAIERAADKEVSS
>A0A0H5CJL8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alloactinosynnema sp. L-07|TrEMBL
MPVWNRRRFLALAIAAPTITVAAKLATDDETADALPSNPQLADLLDFGDVVVLASKPTAG
SMVLEITEDGLVRFELPRAESGQGITTAVAMMLAEELDARVADVRVELSDANPALLWNQF
TAGSTGVRTLWDPVRAIAAAARARLVTAAAQTWSLPPDTLTTRDSAVWAPDGRSAGYGSL
SERAATVVPAVRTTPKPATDHTVIGKPTGRVDARDIVTGKAKFGMDIAVPGALATVVARP
PTIKGTVVSYDDTAARAIPGVVAVTKIPTGVAVSAETMDIALAGRDALQVTWKDGPAVGL
SDSDIRTKLRAAVPPFVVPPLLTQRVDAEFDFAFVSHAPMEVLNAVADVRADRAELWFAC
QSPIVAQREIAAAVGLPVGKVTVHVTRAGGSFGRRLFWDPAIEAAQVSKKIGRPVRLMWT
RTDDMRHGRLRPASHHKIRATFALGQMLSFEHRMASVETDFKHGFGEVVSASGAAVLGPG
DGLMFFHLSASNPYNFGVVTQLLNEVPVPVHTGSWRSVYSGGLRTAEEIVVDQLAAKFGK
DPVSFRMSVLKARRTRDVLAKVAKEGEWGRALPPGHAQGVAVHEEYRSATACLVEIDATD
PAAPRVTRATVAVDVGLPINPTGLKAQLMGGLTDAISTMLTAGVHIDNGRVREKSFADFR
YARQKDTPPRLDVHVMPATGKPGGAGELGVPAAAAAVANAYAKATGTRPRSFPIAF
>I4KXK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha BG33R|TrEMBL
MELRINQKAYQVEAEADTPLLWVIRDNLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGLEITTIEAIEADEVGKRVVSAWVEHQVAQCGYCQSGQVMAATALLKHTPAPSQA
QIDAAMVNLCRCGTYNAIHAAMDGLAAGKETA
>A0A0M7H2B0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter aegrifaciens|TrEMBL
MTHIAQLSRRGFLQGALGALTLTVTARGLITAAWATESPAQKYGADSMPGGTVDDPLVFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWDRVKVMQAQADEARYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPVAEVKAVQHEVLHQPSGRRLTYGELAAD
AAKQPVPAGDALKLKDRAEFRYIGKEHVRLVDLEAIGKGQASYGMDMRLPGMVYAVVARP
PVVGGKLRRLDSAKALAVPGVLKVVEIPPMQGAPAFQPLGGVAIVARNTWAARQGRDALQ
IEWDDGPNGSYDSSAYRQTLESAARKPGKTMRSQGDAAQAWAKAPEAERVAAEYYVPHLA
HASMEPPAATVRIKDGRAEVWTSIQNPIAARDAVAARLKLEPADVTVNVLLLGGGFGRKS
KPDFVDEAAIVARAMPEGTPVKLVWTREDDIHHDYLHTVSVERLEAVLDKNGQVQSWLHR
SAAPTIASLFSEGAKGQQLFESAMSAINMPYRIPNVRVETAEVEAHARIGWFRSVANIPH
AYAAQCFIAELAHRAGKDPKDFALDLIGPARRIDPGTMADTWNYSESPELYPYDTGRLRG
VIEAACKGAEWGRTLPQGHGLGLAFCYSFMSYTATVVEVAVDAKGEVRVVAVDMAMDCGP
QINPERIRAQMEGGAIMGLGLALASEITFERGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHTLPPGGVGEPPVPPVAPALCNAIFAATGKRIRSLPVRRVA
>A0A7Z0AZV5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MLKRRTFLLGGASAVGALLVGWSVLPPGQRLTTSTPLPAEGTQVPLNGWVKIAADNSVTI
IMCKAEMGQGIHTGLAMLLAEELDAEWSQVRVEDSPIDRIYNSVQNIVDDLPFRPDDDSA
VKRATVWMTRKLVRDAGTMMTGGSSSINDLWTPMREAGASARAMLIGAAAAQWQVPAAEC
RAESGEVLHPSGHRASFGELSSLAAQQPLPRNVALKDPANFKLIGKPVRRIEAASKINGT
ARFGIDALPDGLLYASVVMCPTLGGTAAHFDAGPAEKLPGFIKAFAVAPYNGGTGGVAVI
ADNPFRAMNAVTAVTVDWNDGDAAHISSAEVQSRLMQALDGSDGHAYYRLGDVDAALSGA
ARTVSADYHAPYLAHGAVEPLNCTVQVADGVATVWVSTQVPALARHHVAKVLNLDADKVD
VQTQLLGGAFGRRLELDFIAQAAVIARQGGGRPVQTIWSRAQDFTHDFYRPACVSRLKAG
LDAHGKLVAWDSLSAGQAIVPESLARYYGVPRLPIDKTACEGAFDQPYEWPAARVAHKIV
DLPIPIGFWRSVGHSHQAFFTESFTDELAAAAGRDPIAFRAELLARHPRHLAVLKRVAAL
SEWGRPLTHAADGAPRSRGVALHEAFGSVVAQVAEVSLGPGKQIRVHRVVCVIDCGLPVN
PNLIRQQMESAIVFGLSTALQDEITIVDGQVQQKNFVDFPVVRMNDCPAIETEIMPSQLH
PQGVGEPGVPPVAPAVANAVFALTGQRLRALPLKLA
>A0A2N7R933|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. AD21|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIEADDVGKRVVSTWVDLQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHAAVHELAGKGDA
>A0A2N7RET8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. AD21|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVIGQNVSTIDNLHADPVGQVVQQAWLDSAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A7W6FWN3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium fluoreni|TrEMBL
MPRLTVNDRAIEIDLDPVTPLLWGLRDAANLTGTKYGCGVGDCGACMVLIDGEARRSCLV
SLAECEGRAVTTIEGLSRDRSHPVQQAMVAEQAIQCGFCTPGIVIAAAGLLARNANPSDA
QIKAAIPNLCRCGVYPRLLRVVQQASRAMRGNAAAGATPVTTIPSEGTPR
>A0A1A0DDG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus|TrEMBL
MGKLERIAARQDRAAGRGPTRRGFLLTAMGSAFMFGFARQGNAAQVYPQAAGNLPAGGAF
EPTIWCSIAPDGWVNVNVIRAEMGQHVGTALARIIADEMEADWNKVKITYVDTDPKWGLM
ITGGSWSVWLTWDQFRQAGAAARTVMVEEGARLLGVAPSACIARNGQVIAGKRSISYGDI
VSRAHPTRTFTPDEMAKLPLKPSSEHRLIGREVKALDIPSKTDGSAIYGIDAKLEGMVYA
RPKMPPTRYGSKVVSVDDTEAKKVKGYIRYIVLDDPSNTVPGWVAVLASSYPAAIRATDA
LKVTWTPGKTANVTEQDIIEHGRKQIAEKTGGSRIFNDAGVDEALGKADKVVERTYTCSS
VLHYQLEPMNALARLHEGKWEVHCGNQWQTLFLPVIAKALQVPESDVVMRSYLLGGGFGR
RLNGDYAVPAALISKALGGKPVKLVFTRSDDVLFDSIRSPSIQTVRAGVNKDGSINGWEH
HASAGWPTGVMAAAFMEKGEDGKPYDQFAIAGADHWYDVGPILVRALDNDLADATFRPGW
LRSVSSGWTPWAHESFLDELAHDYGKDPVDFRLGLLTCKGRNAGSAPNSVGGASRQANVL
KKLVEKCGYGKVSLPKDTAIGIATTFGQERNMPTWTAGAAQVHVDRETGVVTCQKIWLVL
DAGTIIDPDGALAQTEGGALWGLSMALFEGTEIENGNVRDRNLNTYTPLRITDVPDMDIE
FLPSTEKPMGLGEPGVTTIAPAIGNAIFNAVGVRMRHLPVRPADILKALKEKGNA
>F4KXG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MAEFTLKVNGTKYKVEAAADTPLLWILRDHLGLTGAKYGCGIGQCGTCTVHIDGEAMRSC
ALPVSAIGKAPVITIEGLATKQGEHPVQEAWHEVDVPQCGYCQTGQIMSAAALLKKNPTP
SDADINSAMAGNICRCGTYNRIREAIHVAAKKIKS
>A0A1X1PP72|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia puraquae|TrEMBL
MITLNINGEARSVDAPDDMPLLWVLRDVVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRKITTIEAVGATPAGHKVQQAWRELDVVQCGYCQSGQVMAATALIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAVKQAAKEA
>A0A120FXH1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKAYQVDAEADTPLLWVIRDNLGMTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREITTIEAVEADDVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPAPTKA
QIDAAMVNLCRCGTYNAIHAAMDALAAGKETA
>A0A4Y8ACR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mucilaginibacter phyllosphaerae|TrEMBL
MINLNVNQKAYQVDADPNMPLLWVIRDIIGLTGTKYGCGVAQCGACTVHLNGEAVRSCVT
RVSRAEGQKVVTIEGLSANNSHPAQVAWNEENVPQCGYCHSGQIMSAAVLLRENPDPSDE
DIDAAMAGNICRCGTYLRIRKAIHLAAGLQRKENAS
>A0A484UE76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPGT
PAGWRALAFNGHVDLGTGIRTALAQIVAEELDVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAARWQVPATALRARAGRIVFADEADTRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGVLTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREI
PPAPDLGDLEAALRANRAEPRHLRDDGNTAHALATTPDTRRLRRSYVWPYQMHASIGPSC
AVADHANGRLTVWSGTQNPHMLRVDLDRLLDLGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLIDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGRVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGSDGLLHG
RGVAYARYVHSKFPGFGAAWAAWVVDLRVDPASGHVTIDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPEIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRNALLARKQPGMPRADAPLSDTQPA
>A0A5B7V8R7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. YIM 121038|TrEMBL
MPEHTFRLNGEQVTVEAADDERLLWVLRDLLGVTGPKYGCGINVCKACTSHLNGKAANPC
AIPVKDLAPDDEVTTIEGLAATVDAELHPMQQAWLEQDVAQCGYCQPGQIMAAVALVRRL
AQEGRAVTDADLDGIRNICRCGTYPRIREAIRAGAERM
>A0A1C3K2V9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Orrella dioscoreae|TrEMBL
MHSSDSASSDVPRPPGVRLSVNGRSHTVEVEPAAPLLFVLRNDLALNGPKYGCGLGECGA
CTVLVDGVAARACVMPVRGVIGREVTTLEGLGDVACPGPTQQAFIECQAAQCGYCLNGMI
MMIEALLRRQPAPDEARIRQELRHNLCRCGTHVEILQAARRAVALHAQARETACAKRSGQ
>A0A0S4VDL8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VAAVAGRRITTIEGLAEAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA
>A0A0S4UCU9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MVTLTINGRLVEVDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAAVGAQITTSEHIADDKIGKAVLAAWIKHDVAQCGYCQSGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAARSLA
>Q395Z4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MITLNINGETRSVDAPDDMPLLWVLRDVVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRKITTIEAVGATPAGHKVQQAWRELDVVQCGYCQSGQVMAATALIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAVKQAAKEV
>Q39HK0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MITLTVNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRSCIT
PVAAASGKRVTTIEGLSTDLDHPLQQAWQELNVAQCGYCQSGQIMQAASLLKTNPHPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAVRRGGAA
>A0A853SN64|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MRIEWLNQEALQHGGVTLGAALASAPVAVADGVSRRGFMKAGAAAGGGLMLGFFLPGAGK
LAQAADAAPAKPVYAPNAFLHIAPDNTVTVQVNRLEFGQGVQTSLPMLIAEELDADWSLV
HGALAPAGEQYKDAAYGMQMTGGSGSIAHSFTQYREIGAKARAMLVGAAAAQWKVSPDQV
RAAKGVLYGPGGQKATYGEFADAAMRQPVPATVKLKDPREFVIIGKPVKRLDAAAKSTGK
QQFGIDFKPPGAKVAMVARPPVFGAKVAKFDASKAKAIKGVLEVLEVKTDRGGSGVAVIA
DGYWPAKQGRDALVIEWDTSAVEKVSSDKQLAAFKALAKTPGTVAKPADMDKLAKAPKKI
EAVYEFPYLAHAPMEPLNCVVDLQADKCTMWVGSQFQTGDQAAIAATSGLKPGQVTLHTM
MAGGGFGRRAVPSSDYVVEAVNVAKAYRAAGKSGPLKLMWSREDDIKGGYYRPSHVHRAQ
IGLDAKGKILAWDHTIVGQSIMAGTPFEAFMVKNGVDGTMVEGMGEPYTLPMKLSVHTAK
ANVPVLWWRSVGSTHTAFVMETLIDEAAHVAKMDPVAYRKQLIDARHTRHIAALDLAVAK
SGYGKKKLPKGQAWGVAMHESFNSVVAYVVTASVVEGAPKLHQVWAGVHCNLAVNPLTIE
AQVQGAALMALGMTIPGAAITLKDGVVEQQNFGDYPVPRMQDMPVIEVHLVPSGDAPTGM
GEPGVPPLAPAFANALFALTGKRLRKLPFDLAAA
>A0A6S7BIG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pararobbsia alpina|TrEMBL
MTTLNINGQTHTVDAPPDMPLLWVIRDLVGLTGTKFGCGIAQCGACTVHLDGAAVRSCVL
PVAAVGDKKITTIEAVGETPAGKKVQQAWRQIDVVQCGYCQSGQVMSAASLLAQNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKEA
>F7QID0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobiaceae bacterium SG-6C|TrEMBL
MNKHIKVESSTDLSRRSFIVGTSAAGLALGFASVPGSSALAAPAPAAFDPSVWYSIAPDG
LVTVTCGKADMGQHIASTMAQLVAEELGASWKDMRVQLASNDPKYNDPVLGAQITGGSWS
TMMNFDAMSRAGAAGRIALTEAAAAMMGVPANELVVRESRISHAKSKKSLSFAEIVKSGK
ATKKFSADELKALKLKTPDQYTLVGQSIPQIDIPSKTNGTAKYGIDTFLPGMVYGKIVMP
PVRYGATVKLVDDSAAKKVPGFIKAVTLEDKTGTTTGWVVAVANNYANAKKAADALKITY
DNGPNAKVSSESLLAEAKRLQADSASGLFFVKNGDTAEALGKASKVMEAEYTTNINIHAP
MEPMNATAELKGDIWHVYTGNQFATRSGAIAAGALGVDPKFLVMHQAWLGGGFGRRLDGD
MLIPAVLAAKAVGKPVKVIYSREDDMTMDFSRPLTFQKIKAGLDDSGKLVAFNHDVVSAW
PTKRWGIPAFLSPDVEKKGALDAFTVNGADFFYTVPNHNVRAIINELAQSATPSGQLRSV
APGWTFWAVESMLDELAVAAGKDPAQFRIDMLDGAGANAGGAQRLRNTLLAAMGLAGYGT
KKLPKGEGMGVACVSSQERATASWTACVAHVAVDDSGEVKVKKLTVATDVGTQVNPDGIR
AQVEGAALWGMSLALFEKATMKDGAIEQSNFDSYTPMRMSQVPEVAIAVIANGEPATGVG
EPAVTVVAPALANAIHNAVGARVPSLPITADAVKAGMKKA
>A0A6S7BIL2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pararobbsia alpina|TrEMBL
MSQGLLDAQNGPRSKDDANGRGISRRTFLKFSATVGAAAGGGLLLGFSIPAMSQGQADKS
VIGGDAAEPAQPGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVLLDS
VTIDHAPPNEKLFSDPLLGGQLTGGSTSIRYAWDPMRKAGATARVLLINAAAQQWQVDPA
TCHAQVGQVIHAESNRSIGYGQLVDAAAKLPAPQNVPLKDPKEFKIIGTSVKRLDSPGKV
DGTAVFGLDVRVPNMVYAAIANCPVFGGTLGSVDDSNAKKIPGVRQVVKIDNAVAVIGDH
TWAAKRGVAALNITWNEGAGANLSMKQIVDDLAAAADHGTGAVARKDGDVNKGFNDAKTR
VDAVYQQPFLAHATMEPVNCTVHVRPDGCDIWLGTQVPTRIVDTAVKVTGLPADKILVHN
HLLGGGFGRRLEFDMATQALKIGKQLGTPVKVFFTREEDIQHDMFRPYYYDKISAGLDAN
GKPVAWQHRIVGSSILARFAPPAVRNGLDPDAVEVASDLPYDLPNQLIDYVRQEPRTVPT
GFWRGVGPARSTFVVESFIDELAAQAKVDPVKYRRDLLGKSPRALGVLNTATKAAGWGNS
VPKGQGRGVSVMHAFGSFFSMVVDVTVDQGEVTVNRVVCAVDCGMVVNPNTIEAQVQGGI
IFGITGALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIEVNIVKSGEAPGGIGEPGTAAL
AAALSNAVYSATGRRLRQLPVGSQLKTA
>Q1MGD6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium leguminosarum bv. viciae (strain 3841)|TrEMBL
MITLNINGNQHEVDADPETPILWVLRDTLGMTGTKFGCGAALCGACTIHLDGEAVRSCST
PLSAAEGLNITTIEKATDGSDRVGAAVSAAWVKHDVAQCGYCQSGQIMSATAFLASLPSG
SQPTASEIDTAMEGNICRCGTYVRIRAAVADAASNLV
>A0A157SMZ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella ansorpii|TrEMBL
MLTLDINGRITSLDVPAQMPLLWALRDVADLTGTKYGCGGAQCGACTVHADGHPIPSCVT
PAGAVHGQRIVTIEGVGADRVGQAVQHAWRELDVAQCGFCQSGQIMSAVALLRRHPRPTD
AQIDQAMRGNLCRCATYERIRAAIHHAAAALD
>A0A0D6JB43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Filomicrobium marinum|TrEMBL
MAKINVNGSVLDVAADPATPLLWVLREQLGLTGTKFGCGIAQCGACTVHINGEAQRSCVL
PLESISESDTIVTIEGLSADGSHPVQQAWLQLDVPQCGYCQAGMIMAVAALLEKNPKPSD
EEIDAEITNICRCGTYRRVRKGIHLAAAAKA
>W6VHK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. (strain GM41(2012))|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVTTIDNLHADPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>W6VC86|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. (strain GM41(2012))|TrEMBL
MSALNINGRDYTVDVDPGTPILWTLRDALGMTGTKFGCGVALCGACTVHLDGQAIRSCVT
PIAAAEGRKITTIEAATNGSDPVGTAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTAAEIDSAMAGNICRCGTYARIRAAVADAAKALA
>A0A3G7TMT3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDAFAEEKKFGADGMPHGWVDDPK
VYVSIAADGSVTVLCNRSEMGQGVRTSLSMVVADELEADWALVKVKQAPGDEALFGNQDT
DGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPLAECRAQLHKVIHQPSGRELGYGAL
AAAASALAVPARDSLRLKQPSEFRYIGKEGTRAIDGVDIVNGQAVYGADVHFDGMLFATV
ARPRVYGGKVKSFDGSAALKVPGVIKVLQIDSRPLPSEFQPLGGVAVIASNTWAAIKGRE
ALKIEWDDGVNAGYDSIAYRKELEAAALKPGKVVRSTGNIDEAMSSADSSLEASYYLPHL
AQAPMEPMVAVARFQDGQCEAWAPSQAPQVTRERIAERLGIPFDKVTVNITLLGGGFGRK
SKPDFILEAAILAKEVPGKAVRVQWTREDDIHNSYFHTVSAEYLKASLNKDGMPSGWLHR
TVAPSITALFAPGMNHEAAFELGMGFTNLAYAIPNVRLENPEAAAHTRVGWYRSVSNIPH
GFAIQSFVDELAHKVGQDPLKYQLKLLGPDRRIDPRTLSEEWNYGESPERYPIDTARMRG
VLETAAKAAGWGRSLPKGRGLGLAVHYSFVTYVAVVIEVEVKDDGTLIVHKADIAVDCGP
QINPERIRSQFEGACVMGLGNAVVGEISFKDGKVQQDNFHMYEVARMPLAPKEVAVHLVT
PPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQQASKA
>A0A3G7HAX3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MLTLNINGKDQQLEVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PAATVANGQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPSPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A2S6RJV9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alphaproteobacteria bacterium MarineAlpha9_Bin1|TrEMBL
MAVLNINNTSHVVDAPSDTKLLWVIREHLRLTGTKFGCGVGLCGACTVHLNGEAVRSCQI
ELGDAEGVSITTIEGLDPKGQHPVQQAWLELQVPQCGYCQSGQMMNAAAFLEGNSNPSDG
EILDAMQGNICRCITYARIKTGVRRAAQIIQGA
>G0EVK3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MLTRRAFLLGGAGAAGALVIGWAWLPPRQRLAGGEPLAVRDGQVALNGWVKVASDNTVTV
VMNKAEMGQGVHTGAAMLLAEEMEADWSQIRVEPSPVDNLYNNIEGVVANLPFRPDDKGW
PRRAAEWFTRKGVREVGLMFTGGSTSIRDLWTPMREAGAAARMMLCAAAAKQWDVKAEAC
RAQAGKVVHPSGRNATFGELAAAAAREPLPRQVELKDPASYRLIGTRAARLDAAAKLHGT
ASFGIDVVADAMVYASVQMCPTLGGTLQGSPPDDVKKLPGVLDVVALPPLQGGSGGVAVI
ASDAWIAMQAVEKVQCKWDEGGARTLSSDGIRDTLVKALDASNPRVWYEHGNGRAMKQGK
PAIQVLYSAPYLAHAALEPVNCTVLVQEDRAIVWAATQMPGLARRCVAKTLRLDTDKVEL
RQQSIGGAFGRRLEVEFICQAAAIAAQRKGVPVQTIWSRPEDMRHDFYRPASVSRFEAWL
DGNRKVIAVRNISASQSVLEGVAKRNFGLPDIFVSRLDKSTVEGAFDQAYDWPDVWVGHQ
TVDLAIPVGYWRSVGHSHHAFFMESFVDELAVAVGVDPLDYRMSLLRDERQRAVLEQARK
MSGWGQPLRKQPGVVKVGRGVALHESFGSVVAQVAEVSVDNAGQVRVDRVYCAIDCGMPV
NPTLIEQQVEGGIVFGLSAALWQKITLKAGKVQEDYYTAFPAMRLRDCPDIQVHVMPSMR
SPQGVGESTTPPIAPAVANALFHATGERLRDLPLLKTLPPSGACDARQSDQCQR
>A0A5C6F6C7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubripirellula tenax|TrEMBL
MASITVNGNRLNIDGLSSDTPLLWVLRDHLGLTGTKYGCGISECGVCTVHLDGEAIQSCV
TTLGEVGDGEVTTIEGLSKDGSHPVQKAWREHNVPQCGYCQVGQMMMAAAMLRSNNDPTD
EDIESEMWNICRCGTYPRIRAAIKSAAKEMQSK
>A0A7W5ZV12|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium hassiacum|TrEMBL
MRLTRRGLLVGAGVGGALLIAFPLIPRRHAVPLVAGKGEHVVDAFLKLGKVRGPGGKSDC
ILTVAVPFCEMGQGITTLVAQIVAQEAGADWRKVAVEAAPISPAYADPVLSAKWAPLWMP
AFASLGDDPAGILPRLHAERGPMMITADGTALAAFETPLREAGAALRALMAQAAADKWGV
GWEECETRNSVVIHGNKRLSFAELLDSAVAYDPPDPPVLRAEPPRQRPGQFPEGFPASHP
RLDLPAKVDGSFNFAGDIRLPGMVFAAIAHGPQGSSLLSSYDKQAAATVRGLVGVVRAKR
WLAAAATNWFAADKAVRAMEPRFKADGPIADSEKVLLALDKALTRGEATRISAEGDPDAL
LQKPALSARYDVEPAFHAPLETASATARMRQGKLELWIATQAPERARRAAARAANLPRHD
VIVYPLHAGGSFDARLDVRIAAEVAAIATTLGKPVQLTCSRWQESLAGIPRTPLSAQLDG
ALSPDKSRVLGWRAKLAVPATVRESGARLLDGWGVGNALDLQDRADPMACEGAMPRYRIP
EKAVDHVPLALGLPTARFRGQAHGYTAFFTESFVDEMAHLAGREPLSFRVGMLDGEPRLV
ACLTGVARLAQWGGGIEASGQGIACHRMDLATADDTVRSGHIAVVATARQEAGVVRVERL
SAFVDIGRIVNMDIARQQIEGGLMFGLAHAVGGSSGYAKGRPLAGRLSQLGLPLLADCPK
VDIAFADSNEQPFDPGELGMVAVAPAVANALFSATGARFRRLPLISEGL
>A0A7W9BS95|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas prati|TrEMBL
MSYSLTVNGQVRHVDEDGQTPLLWVLRDTLKLPGTKYGCGIAQCGACTVHVDGQPMRSCS
LALEAAAGSQIVTIEAVDGPQADAIRDAWVARDVPQCGFCQSGQIMSAVALLRSVPKPTD
ADIDIAMSGNICRCATYNRIRAAIHDAAGSAQS
>A0A840L3J9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paucibacter oligotrophus|TrEMBL
MELKVNGQRMQLPEHASDPAMPLLWALRDGLHLTGSKFGCGVAACGACTVHVDGQAARAC
VTPLGAVQGKAITTIEALGTAEHPHALQIAWLAEQVPQCGYCQSGMLMAAAALLARNPKP
SDADIDAAMTNLCRCGTYPRVRRAIRQAAALGARR
>A0A840Z764|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas endophytica|TrEMBL
MTRLTVNNEAVEYRMAPDTPLLWALRDASNLTGTKYGCGTGSCGACTVDIDGKAVRSCQV
ALRDVEGTFVTTIEGLSRERAHPVQLALIAGNVPQCGYCIPGITMMAAALLKRDPMPSDE
AIRAGITNICRCGIYPRLVEAIQRAGRAIRGDERLPAAPRPGIDPAEAARRVPALDPAAG
R
>A0A2L0HGE4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium fredii|TrEMBL
MAIVTINGVEHSVDAAADMPLLWVIRDLVGLTGTKFGCGMAQCGACTVYVDGSPVRSCQT
FIGDIEGAKVTTIEGLKGKVAETVQSVWADLDVPQCGYCQSGQIMSATDLLANNPKPSDE
DIDAAMSGNLCRCATYHRIRAGIHEAAKRLEA
>A0A2R5FC33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novimethylophilus kurashikiensis|TrEMBL
MISLTINGKSTKVDADPNTPLLWVLRDHLQLTGTKFGCGMAQCGACTIHLDGEAIRSCVT
PLSAAAGKQVTTIEAIGETQAGKALQAAWLDADVPQCGYCQSGQIMSAAALIKQNPQPSD
DQIATAMNGNICRCGTYGRIHSAIKQAAEDLKKGGAA
>A0A7W6T474|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. SBR1B|TrEMBL
MANLTINGKTFTLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHIEGVATRSCGV
SVSEAEGKKITTIEGLASGDALHKVQEAWIAQDVPQCGYCQSGMIMAVAALLSEKPKPTD
ADIDEAITNICRCGTFQQVREAIHTIASA
>A0A401MR84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. NL15-2K|TrEMBL
MPSHTFTVNGKTVTVDAPDDLPLLWALRDLLGVRGPKYGCGIDVCKACTSHLDGEAIRPC
VVPVAEAAGHEVTTIEGLADGDRLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKRTSDP
TDADIDEIANVCRCGTYFRIREAIKSAAARMG
>A0A1A9GG73|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides dokdonensis FR1436|TrEMBL
MPKQTFILNGKPVTVNVNDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVRVGDLGRGDEVTTIEGLPDTVGGDLHPMQEAWIDRDVPQCGYCQPGQIMAAVALVRKV
RREGREIGEADLDTIRNICRCGTYTRIREAVVQGARGMA
>A0A852W1J0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia antarctica|TrEMBL
MPSHTFTVNGEKVTVDVEDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVGALSESDEITTIEGLAKGEELHPMQQAWIDNDVAQCGYCQPGQIMAAIDLVKRCAA
EGRSIDDDALDEIRNICRCGTYNRIREAIKAGADTM
>A0A379YTZ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica|TrEMBL
MAEVLSTKAVVKEANTASSTQTLSAQTLTINGKSFTLDADPKMPILWALRDILGLTGTKY
GCGAGLCGACTVHLDGQPVRACLTSLGQAQGKRLTTIEGLDNQKLKNAWAEHNVPQCGYC
QAGQLMSAAALVAQHPKPSEEQINSAMSGNICRCGTYPRIKAALQNYAKQEG
>A0A5B9MIZ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stieleria maiorica|TrEMBL
MTSINVNGKVHDLGDVPDDTPLLWVLRDQLGLTGTKYGCGIAECGICTVHLDGVAVQSCI
TQLSEVGDSKVTTIEGLSEDGSHPVQKAWKQHGVPQCGYCQVGQMMMAAAMLESNHDPSD
DDIDGEMWNICRCGTYPRIRAAIKTAAKEMQTR
>A0A0M6Y7K6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium aggregatum|TrEMBL
MLHLLKQPLAAAMPTRRTFLKMSAGTVGGLVLAMNLPRSTASAAEGEFIQPFVHIRPDNT
VVVLSKHFDMGQGTASGLCSLVADELDASWEQVSVEFAPSNPQVYANSLFGVQGTGGSTA
MANSFMQYRQAGAAAKAMIIAAAAKEWGVPAGEITVSGGVVSHGADKSATLGELAGLAAN
EDVPAEPTLKTPDQWVYIGKSFPRLDVKNKTVGAPRTYTMDFQRDDLLVAVVARSPRFGG
KVKSFDATEAKKVPGVVNVLQIPNGVAVIAKSTWPAINGRSLLEIEWDDAEAETRSSDAM
IAELKDMTTKPGVKVREDGDVDAALEASAKVIEADYDFPFLAHGAMEPLDIAMMFDGETA
EFWFASQIPTIDHNVAATVLGIPFENVKINTLWAGGSFGRRAQADAHPVVEITTLAKAMQ
AAGMAPAPVKIVWTREDDMAGGYYRPMSAHRLRVGLDDQGNVTAFKYNIAAKSIVKGTPF
EAMLMKDGVDHNMTEGAHDTTYAFPLMNMDQSFQETKVPVLWWRSVGHTHTAYVMETMID
RLAKEAGKDPVAYRLEMIKDDPRKVGVLKLAAEKAGWDTPLPEGRHRGVAVHKSFGSFVA
EVAEISFRDDGTVKVEKVTAAVDCGTPINPDNIRAQVEGGIGYGLGAILRNQVTLADGVV
EETNFDTYEPIRMSDMPEIEVHIVPSNEAPTGIGEPGTPPIGPAVANAIAAAKGEWSTSL
PLAKSGLV
>Q8XY73|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum (strain GMI1000)|TrEMBL
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VAAVAGRRITTIEGLAEAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA
>H0TRX9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MAAFTLKINGREHQIDVDPNTPLLWAIRDNVGLTGTKYGCGVAQCGACTVHLDGQTLRSC
SLPVSAVGKSEVTTIEGLNSKEGGAVQKAWAALDVPQCGYCQSGQIMSATALLELNPKPS
DQDIDLAMNGNLCRCATYVRIRAAIHAAAKSLEG
>A0A1E7X8E1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella phyllosphaerae|TrEMBL
MSRVDETVSAGRRQLLQAAGLSVAFVWLATPKTALGMVTPHRQAGDAKAAAADGAPAFAP
NAFVRIDTSGAIRLVMPMVEMGQAIYTGSCMLLAEELDVDLDQIQVEHAPASDELYGMKL
LKGQITGGSTSTRSTFTELREAGAIARTLLVSAAAAKWKVAPADCVVERGVIRHPASGRK
LAYGQVAAAANQLPDPGAVKLKSPAEFRLIGKPMARLDSADKVYGVTKFGIDVSVPGMRI
ATVKACPTFGGKLVKFDDRATRTVPGVIDVIRIDNAVAVVAIHFGAARRGMELLEIEWDR
GANATLTTRDLRAGLAASQANGKAIPGREAGTRPAGELIEATYKLPMLAHATMEPLNATV
HVTADCCEIWAGTQVPTRVVANAARITGLTVAQVVLHPQYLGGGFGRRLESDYVDQAVMF
ARLVKYPLKIIWTREEDIGHDIVRPMYHDVISAVVDASGMPVWYGDRICSATVLGRWRPG
GMRPNGLDGDAIECVADMPYAIPNMKVEWVRHDMPPGLLVGWWRGVGALHNLFIVESFFD
ELAHRAKADPVAWRRALLRHNPRATAVLDLAATRMGWGAALPARVGRGVALGEPFGSKVC
AMVEVEVTPAGDVRLRRAVVAVDCGIPVNTGSIEAQIQGGLLFGLSAALFNEVTIANGAI
EQSNFNDYRMIRMNETPDVEVHIVPSTEAPGGIGEVGTAIAAPALANAIFAATGVRLREL
PIRRELLAQKRSKA
>A0A0F7KV30|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Croceibacterium atlanticum|TrEMBL
MAYRLSINGVEHEVDVPGEMPLLWVLRNELNMVGTKFGCGVGLCGACTVHIDGQAQRSCS
FPVSAVGESRVSTIEALAETETGQALQQAWLDEDVMQCGYCQAGQLMSATALLDRNPQPS
ARQIDAAMQGNICRCACYTRIRDAIAQVAEKKDTANV
>A0A841QD77|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter lovaniensis|TrEMBL
MLSLNINGQSHQVDVDPDTPLLWVLRDVLGMNATKFGCGIAQCGACTVHMDGRAVRACNL
PVGLIGEQHISTLEGLNPADPVTKAVQDAWVALDVVQCGYCQPGQIMAAIALLRAVPHPT
DEQIDSAMSANLCRCGTYVRIRAAIHHAAGALA
>A0A3S5B3A5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MNIQINGRMIPLDDSLRDTPLLYILRNDLALNGPKYGCGLGECGACTVLIDGVAARSCSV
NAASVVGKSVTTLEGIGDAEHLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFERDPQADE
QAIKQELAFNLCRCGTHIEILRAAQRAKQIVAERGNA
>A0A165PIK4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. Ad26|TrEMBL
MRLFVNGSEFDVPDSWQDETLLMVLREQLGFVGPKLGCGQGECGACTVHINGEAARSCSI
YAIDVQSDSITTIEGLASADGVLHPVQQAWLDERVAQCGYCQAGQIMQATALLNEEPNPD
DQTIIDHMSNNLCRCGTYKRINLAIKNASQVMQTRKAS
>A0A3S5D7Z7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera|TrEMBL
MLSVNGQHVQVRVMADTSLLLVLRNDLALNGPKFGCGLGECGACTVLIDGLAARACVIPA
RGVTQRAITTLEGLGNRDCLHPVQRAFIEQQAAQCGYCLNGMIMTTQGVAGS
>A0A7X6FJQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MSKAASDISRRSLLKGALVLGFALPVASKLKAANLAPGAAPLSPTGKVLMPSGFISIGPE
GVVFIIPNVEMGQGIYTAEAMLIAEELDIGLDQIKVVPAPPNPELYTTPLLHFQGTGGST
SIRSWWEPLRSAGATARMMLVTAAANRWQVDAGSCVAAGGRVSHRATGRSLAYIEIAAEA
AALPPPTGVILKDPADFKLVGKSSKRVDMPGKVDGSAIFGLDVRVPGMKVASVIASPVFG
GRLKSVDDSDALKIPGFIKVIKIDNAIAAVADNTWAAHRSAAALKIQWDDGDNINVSTAS
IREELVTASKDGTPIVALNQEGAIEGLSKGTKRVDATYELPFLAHATMEPINTIVHVQPD
GCDIWCGTQVPATAVMLAAQITGLPQENVRMHNQLIGGGFGRRLEADSIAQATAFAKQVD
YPLQVVWTREEDIRQDYFRPAYHDQVSAALGAGGLPIAMWHRTTGGSVLARFAPAAMGPD
GLDSDVVEGSVEIPYDIPKRRVDWVRHDPPKGLPFSWWRGVGPAHNVFVIETFIDELAHK
AGQDPIEYRAKMLTHNPRALAVLNLAATESDWATPLPARHGRGVSLHQAFGSFCALVVEV
AVWPEGTIKLIKATAAIDCGFTVNPDTMVAQIEGGTLFGLSAALFSGIEFEGGKTVQSNF
HDYRILRIDEAPRMAVHHIQSAENPGGIGEVGTASAFPALGNALFAATGVRLRSTPFDHT
KLVSQSSDKPVLGSLAPTAGISLALGAFAKMTGIASSGGTE
>A0A7X6FJD0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MTSIKVNGQAVDVDAPDDMPLLWVIRDLLGMTGTKYGCGIAQCGACTVHIDGRAVRSCVM
PVSAVGDRNITTIEAVGKTDAGRRIQSAWLQEEVAQCGYCQSGQIMSAAALLAHVPNPTD
SEIDAAMSGNICRCATYERIRRAIKEAVTL
>A0A7X6J960|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MSIPATINGKRIELDGPLDMPLLWALRDLLGMTGTKFGCGVGQCGACTVHLDGKPVRSCV
LPIGDIQGNITTIEGVAETETGRRIQDAWLRHEVVQCGYCQSGQIMAAAALLSRDSAPDD
AEIDAAMSGNICRCCTYVRIRAAIKDA
>I4KQT1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens Q8r1-96|TrEMBL
MITLKLNGKDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVNGQNVSTIDELHVDPVGQIVQKAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A238KQ09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actibacterium lipolyticum|TrEMBL
MKLTVNGNAHDLDVEPDMPLLWALRDELGITGPKYGCGIAMCGACTVHIDGVAVRSCSVQ
VGDVDGDVTTIEGLGTPDAMHAVQAAWFEHQVAQCGYCQSGQIMQAASLLEENPAPTDED
IDDAMSGNLCRCGTYPRIRAAVKTAAAKLSEG
>A0A7W6MR41|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantimonas endophytica|TrEMBL
MRNSSITNISRRGILGGIGASAFVLAVGLPFRGWAQEEEPKFGRDAMPNGWSDDPKAFIS
IAEDGLVTVTVHRSEMGQGVRTSIAMVVADELGADWDQVRVDQAPGDEEKYGNQDTDGSR
SLRHFFMPMRRAGAAARRMLEQAAAAEWGVDVAEVKAEGHRVNHAVSGRSLGYGELAAAA
MDLDVPPADSLVLLDPSQFRYIGKSDIGLADNMGITTGTAIYGIDVRRDGMLYAVIARPP
VYGGRVKSFDDSAALAIAGVEKVIVIDPVDFPTEFAPLGGVAVIAKNTYLAMKGRDALTI
EWEDGPNASYDSEAYRELLSKAANAAGGTVIRDQGDFDAGMAGAARTVEAEYYIPHLAQA
PMEAPAAVVEIRDGKAEAWACTQAPQVTRLRLAERLKLDKENVTVNVTLLGGGFGRKSKP
DFVLEAGILSQAMDGAPVKLTWTREDDIHHGYYHTVSVEKMTAGLDDSGMPVAWLHRTAA
PTIGSIFAPDPKQKLPFELGMGLLNMPLAIENIRAENPEASAHVRIGWYRSVSNIPHAFA
IQSFISELADAVGRDPKDYLLEVIGPARLVDPRELGDVWNYGEDPEVYPIDTGRLAAVVE
EAAKGIEWGRRMPAGQGLGIAGHYSFVSYVAVAAEVAVEDGVVSVPRVSIAIDCGAQVNP
DRIRSQMEGAVIMGVGQALMTEVTFANGRAQQDNFDSYLVPRMEAAPKRIDIHIVNAGNA
YDRPLGGVGEPGLPPVAPAITNAVFAATGQRIRRLPIAGQLQS
>A0A0S4TP48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MRIRNLEALAGGGAHDPAAPACADAGVATLDRRSFLKLTALAGGGFALGVAPMLAGAQDA
AAKPPSPPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAG
DPYKDPLFGIQLTGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSACRTANGVVT
AGSHRATYGELAQAAMALPVPRQVALKNPSQFRLVGKPTPRLDARAKLDASLKFGIDTRL
PDMKVAVVARPPRFGGKVAKYDAAAAKAVKGVVGVVPIQTDRGGSGVAVIADGYWPAKLG
RDALQATWEDAGSRVSSAVLMNEYKTLADQPGTVAKAADVGAIQSAAKRIRADYEFPYLA
HAPMEPLNCTIDLQSAGGKVGAARVWVGSQFQTVDQGALAKALGIAPEKVELNTMMAGGG
FGRRAVPTSDYLVEAANVAKAYAAAGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKGTPFESYMFKNGVDATMTEGVIENDYGFPMQVSVHHPDVEVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPVAYRLARFTDKEHARHRQALRLAVDKSGY
GKRKPPKGQAWGVAVHASFESVVAYVVEVSIDQGKPRVHRVTAGVHANRVVNPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGAARNSNFPDFPPVRMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDTV
>A0A089Q5T4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium oryzae CBMB20|TrEMBL
MLNARRPNPLPARPSRRGLLAGAGALVVAFRLDPKSARAASGPNLADVKAQPNAFVRIGA
DDTVTVVIKHLDMGQGNTTGLATILADELGADWSKVRTEFAPADATLYNNSLMGPIQGTG
GSTAVANSWFQLRKAGAAAREMLMAEAAFRWKVPVSEITVADNIVRHAPSGRQARFGELA
ASAASLPVPSEPRLKDSSEWRLIGQTIPRLDSVAKTNGTAIYSLDIRRPNQVTAVVARAP
RFGATVKSFDAAAARKVAGVLDVVQVPTGVAVIARDTWSAMKGREALTVAWDDSTAETRS
SDAILAEYRERAKGPGLTASERGDPQAALRGAAKVVEAEFTFPYLAHAAMEPLNATIERA
ADGGYDVYAGFQFQTVEQATMAAILGVTPDRVRLHSNWAGGSFGRRATPTADYLAEAATV
LKASGEKAPVHLVWTREDDMAGGYYRPTVLHKVRAGIDAKGAVVGWDHVMVGKSIMIGSP
FEAMIVKNGIDSTTVEGASDTPYALPAYRFGVHNGREGVPVLWWRSVGHTHTAHVMEVMI
DELAHAANVDPVAYRLSLLTQAPRLSGVLKLAAEKAGWSARPQDPGRGLGVAVHESFGSY
VAMVADVTAQENAVRVNRIVAAVDVGVPVNPDVIRAQVEGAVGFALSSVLRNRITLKDGQ
VQEHNFDAYAPTRMSEMPTVEVHIVPSQVAPTGIGEPGVPVLGPSIANAVFAATGRRLRS
LPLDLSGVKGA
>A0A7W8SUV9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WSM4180|TrEMBL
MGEIVNLSRRGVLKGTLAGGVVLGLQIGGAGTAFAASVLSSANGAKGAFAPNVYVSVAPS
GEIILVVHRSEMGTGIRTSLAMILADELDADWNAVKVVQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGTARQMLVAAAAVQWRVAPATCRTEPGHVVHAASGRRVAYGALAMAAARQPV
PGRDTLHLKDEGTWRYIGKSLPIVDLDDIVHGRATYGIDVVLPRMTYASIERSAVYGATL
KSVDSTETMKVPGVLHVVRIPAAPLPAGFQPLGGVAVVATSTWAAMQGRRKLRLDWDLGP
NASYDSQAYRKALEDTARQPGKIVRNNGDTAAALKSAAHHVSADYYVPHLAHAAMEPLAA
TASYANGAVEVWTATQNPQQARTTVAQVLGLQEPAVTINVTLLGGGFGRKSKPDYVAEAA
FLSREVGAPVKLTWTREDDVHNDYFHAVCAQHMEGGLDAQGKTVAWLHRTVFPSISSTFK
ADVRYGAAGELGQGVTDMPYDIANVRCENGAASAHTRIGWYRSVYNIPHGFALGSFVDEL
AAAARQDPVQHLLTLLGTPRHVDLHALGVDYPNYGASIDEYPIDTARYAAVVRAAAVRSG
WSTALPARHGRGIAVHRSFLSYVAAVAHVQVADDGSVRVTRVDLAVDCGRIVNPDRVIAQ
FEGAVVMALGNTLYSELTFRNGASEQSNFTDYQVARIDSVPETHVYIVPSNAPPGGVGEP
GVPPTSAAICNAIFNATGQRIRALPVDTSLLKRA
>D8NAZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum CMR15|TrEMBL
MDLDVNRRPVKVECDLATPLLWVLRDHLNLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VAAVAGRRITTIEGLAEVPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA
>A0A7X6BFD2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas trueperi|TrEMBL
MTLSITVNGKRHQVDASPETPLLYVLRDDLGLNGAKYGCGLGQCGACTVQLDGKAIFSCI
TPVSAVGDRPVRTVEGLGTVDRMSPLQQAFRDEQAAQCGYCIAGMIMRAQALLDADPRPD
EAKIRAHMQTNLCRCGTHMRILRAIRRVAGLPSDGAAA
>A0A375CHJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGSVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLKDNPSPRP
EEIRAGITNLCRCGTYPRIERAILRAANAQNAGDPKGRASS
>A0A7Z7NKJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEAHADAGVATLDRRSFLKLTGLAGGGLALGMAPLAQAQEGAR
PKAAPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRATLAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVIT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIIGKPTPRLDARGKMEATTPFGIDTQL
KDMVVAVVARPPRFGGKVKSFSADKARAVPGVLSVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSRVSSQALFEEYAKLAGQPGTVARAGEGDIAAAIQRAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQAVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVGAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNPMSAE
AQIQGACVFGLAMTKPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSQENPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A8E0G8Y5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia thailandensis MSMB43|TrEMBL
MTTDLDLPNAVRASRRTFLKAAGAAAAVGLTIGFEWRDAGRPALAATAPAADAGAAGAFA
PNAFLRVAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWRDVRVESAPADASRYANL
QFGKLQGTGGSSAMANSWMQLREAGAKARAMLVAAAAAQWNVPAAELTTGDGAVRHAASG
REATYGSLAAAAAALPVPEKVTLKSPADFRLIGKPVPRVDALAKSDGTAQFTIDVTMPGM
LVALLQRPPVFGGKVKSFDASAAKAVPGVVSVVQVERGVAVVAKGFWAAKQGRDALKVEW
DDSNAEKRSSDAIMREYRQLAERPGASARRDGDADHALAGAAKRISASYEFPYLAHAPME
PLDAVVKLTADSCEIWAGDQFQTIDQGNAARVAGLDPSQVRIHTLYAGGSFGRRANAWSD
YVVEAVSIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAALSKDGKLVGWRHRIV
GQSILAGTPFEAVMVKNGIDQTSVEGAANLPYAIPNVSVELTTTKAGVPVLWWRVVGSSH
TAYAVEAFVDEAAHAAGKDPYLFRRDLLAHAPRLKAVLELAAGKAGWDPAKPLPKGRGRG
IAVAEAFRSYVAQVAEVSVDEHGAVKVERVVCAVDCGTAINPDVIAAQMEGGIGFGLGAV
LHGAITLKDGKVEQNNFDGYRVLRIAEMPKVEVHIVPSGEAPTGVGEPGVAPIGPAVANA
IFAATGKRHYALPFPAAGEAAA
>A0A447Q6T7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia plymuthica|TrEMBL
MITLTVNDQSLTFDGDTHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAVGKKITTIEAIGETPAGKAVQDAWVNLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMGGNVCRCATYVRIRAAIHQAAKALD
>A0A679JS45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hyphomicrobium sp. ghe19|TrEMBL
MRTNLASEPNPLSRRDLLKAGAAGVLLLSFRLPIARAADERFAPNGFIRVGNDDVVTLVM
PQVEMGQGIYTSLGMILADELDADFNKVVLEHAPPDEKLYANPVFHIQATGGSTSVRAFW
MPLRKAGAAARAMLIGAAAQQWKVDPSSCRASNSEVIHDASGRKFGFGALAAQAATQKPP
SDPPLKPLKDFTLIGKPIKRKDTPEKANGTAQYGIDVMPAGVQFATIAECPVFGGKVGRV
DDTKAKAIKGVRQVVVLDDLIAVVGDSTWTAMQGLDALDITWDEGPNVAIGSAEVWDALR
NASKGGGVVAKEQGDVKAAFAAGDRYEAVYELPFLAHATMEPLNCTVHFTKDACEVWTGT
QVIARVQSEVAKALGLPTEKVTVHNFLIGGGFGRRLEPDMAVKAALIAQHVEGPVKVIWR
REEDMQHDVYRPVYHDALAASVKDGKVTGWTQRITGAAIIARWLPPAFQKGIDIDAVDGA
TDNPYGVPNVRVEYVRAEAPAVPTGFWRGVGPNNNFFASESFIDELAHRAGADPVAYRLN
MLDATPRLKAAVQLAASKSGWGGALPARTARGISAQTAFGSFIATVCEAEVDENGEVRVR
RFVSAVDTGLPVNPDTIVAQLEGGLIFGLTAALFGEITIAKGRVEQSNFHDYRMLRINEA
PKIEVHLISSTEYPGGIGETGTTAAPPALTNALFAATGVRLRRLPIDRDALAGRKPA
>A0A0P0MFL6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limnohabitans sp. 103DPR2|TrEMBL
MYSLNVNGKVQKVDAEPEMPLLWVIREVLGLTGTKFGCGIAQCGACTVHVDGQAIRSCSI
PGSAMTGRKITTIEGLSANSSHPVQKAWAQVDVPQCGYCQSGQIMAASSLLKRKPKPTDK
DIDEVMTNICRCGTYQRIREAIHVAAGTRKLPKMDADEVSALVQQIKV
>A0A2X2IEZ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MITLTVNEQPLTFDGDPHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAEGKKITTIEAIGETPTGKAVQAAWVNLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMSGNVCRCATYVRIRAAIHQAAKALD
>A0A239STP4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea sputorum|TrEMBL
MTQQNAERTASPVSETAPESSSRRQWLKGMSLAAGSLLIPISASWLTSPEARAADAADGH
LIEINDWIRIDADGTTVLGLSQCEVGQGVYTGLPQVLADELDADWRRVRVEFVTARDAYR
TAAANEALQQFVGASMSATLFYERLRIAGAQAREALVAVAARRFGVRTTNCVTRDGRVMH
PQSGRSLGYGELAAEAAKLPLNPHPRLKNEATHSLIGKTVSRLDTPSKVDGSAVFGIDVK
VPDMLIGAILMAPTSGGAPLSVRNRDAIKARKGVHDVVLAKDAVIVVADDYWRAKKACDA
LDVEWKAGPAADSTTIMAQRREALVKAKGGVATNIGDAPALIAAGGKVVTSEYHTPYIVH
ATMEPVNATVHVRRDKGEIEVWGPIQGQDKVRWALGGIFKLPPEKVTVHTTFLGGSFGRK
YVPDFVIHAAVASAAVGRPVKVIRSREDDIRHGFYRPCASGRFQAVLGDDGLPKAMHMRV
AGQSMYNVIKKDHYEKAGYDETMLDGLYDLVYAVPNLRVEGIDVPQPNIPVSFMRSVGST
SSVFFLESFIDEMADAAGIESIAYRKRLLKHDPLATRVVEETEKAAGWRTKAKAGVHRGF
GYCTYTGRGAAFSTYVAVAVELRVVGDRFKVERVVCGVDCGRAINPNLIRANIEGGIGFA
LTNTFKSQITFANGGVEQSNFGDYPLLYLVEMPKVETVILPSDRPPQGCGEVSLPPMAPA
VAQAIRRATGVRPRSMPLPQTVTEARALRQADDTGKGQG
>A0A388RCC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MRIRGIEALAGGQGGNDGAAQGGGIATLSRRGFLKLTGLAGGGLALGVAPLAQAQEAGRL
KAPPPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRATLAPAGDAY
KDPAFGMQMTGGSTALNHSFEQYRELGARARAMLVTAAAQKWQVDPASIKVEQGVLASGS
HRATFGELAQAAMELPVPQRITLKDPSQFRIVGKPTQRLDARGKMAATTPFGIDTKLDKM
VVAVVARPPRFGGKVKSFNADKARAVQGVHGVMQVPVDRGGTGVAVVGSGYWPARMGREA
LEIQWEDAGSKVSSQALFDEYAKLAAQPGTVARPGEGDIGASINGAARKIDAEFRFPYLA
HAPMEPLNCTLQPEVSGGRLQAVKVWVGSQFQTVDQAAIARTLALAPDKVVLNTMMAGGG
FGRRAVPTSDYLVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIGFDA
QGKVVGWQHTVVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQVDVP
VLWWRSVGNTHTAYVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVDKSGY
GKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNPLSAEAQI
QGGCVFGLAMTRPGFAIEIENGAVKNSNFTDFPPPRITDAPVVEVFFVPSQENPTGLGEP
GVPPIAPAVANALFRLTGKRQRQLPFELA
>A0A6J4H5T7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Acetobacteraceae bacterium|TrEMBL
MLEFTLNGAAVSLDVPGEVPGDASLLHVLRGPFGLSGPRFGCGAEQCGCCMVLVDGEPAC
SCTLAASAVRGRAVVTVEGLGTAAAPHPLQAAFLAEQAGQCGWCLPGILVSAAALLAADP
DPDDGAIRRALDPHLCRCGSHNRILRAVKRAARAMRDGSAA
>A0A6J4IKX1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Acetobacteraceae bacterium|TrEMBL
MTDTAAPRASRRDVLATAALAGFTFGFHVPLAGKAAAQAAPAAPPEVNAWVVVKPDDAVV
IRIARSEMGQGTLTGLAQLVAEELDCDWSKVSTEYPTPGQNLARNRVWGSFSTGGSRGIR
ESHDYVRKGGAAARAMLVQAAANGWGVPAAECRAADSVVTHVPTGRTTTYGKVAEAAARI
EPPRDVPLKDPRDWKIAGRPLPRLDTVEKTNGKQVYGIDLKLPGMLNAAIRDCPVFGGKV
QSFDAAAVNGMPGVKRVVRVGETAVAVVADTWWRAKTALDALPVVWDEGPNAGVSSATIA
AVLKEGLDAADAAVGNRAGDARTAIAGAAKKVEAVYSYPFQNHATMEPMNATARWTPERC
EVWTPTQNGEGALAATAEAAGLPPSSCDVHKVHLGGGFGRRGAVHDWVRQAVAIAKEMPG
TPVKLIWSREEDMLHGRYHPVTQCKLSGGLDAEGNLVGLAMRISGQSIVAGIFPQNIRDG
RDPVVFQGLNPDGAEAAIGYTVPNILIDHAMRNPHVPPGFWRGVNLNQNAIYLECFLDEL
AHAGGKDPLEFRRRLMANHPKHLAVLNAVAERVGWGNPAAPRGGQAVHRGLAQTMGFGSY
VAACAEVSVADDGKLTIHRIVAATDPGHAVNPQQIAAQVEGSFVYGLTAALHGECTVANG
RIEQENFDTYPMMRMDEMPAVETIILPSGGFWGGVGEPTIAVAAPAVFNAIFAATGKRVR
SVPLKHTDLRKA
>A0A1M4E4G7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea gerenzanensis|TrEMBL
MMGSPSGESGRAVGSPADERGPAVGSPAGESDPGMLLVSEDGVVSVRGDGVIFVRAGKSE
LGQGVLTALAQIAADALGADVAQVRMLAASTGAGPDQGFTAGSLSIAVAGPPLRETCAGV
RAACTAEAARRWGVSPGEVMVRRGEFRCGDRTATYADLAQVADAPRAEATQADAAQADAA
QAEAPVFVGVSVPRLDLPDKIAGRPRFIHDLRLPGQLYGRVLRPPSPAARLTRLAPLPDL
HVVRDGSFVGVLAETEADADRALARVARAAEWEEHDTLPDEHDLHTFLRRGPHETITVRT
PAGPAPEGEPHAATYSRPFIAHASIAPSCAAARWNPGGDLEVWSHTQGVHPLRRALMKIL
EAEVEVHHVEGAGCYGHNAADDVALDAALLAREAGGRPVHVRWSRRDELTWAPFGSAMSV
DVAAVVDEAGLVRSWRYDVWSQGHLSRPGYAGGVPGLLAGAHLERPWAYPAAVDPSPQSG
SGMARNAVPIYDFPRLEITGHRVLETPIRSSALRSLGAFMNVFAIESFMDELALAAGMDP
LAYRLAHLSDPRARMVLERAADAAGWGEPGLGLGFARYKGIGAYCAAVAEVEAEQDVRVR
RLTIAVDAGQVVSPDGVRNQIEGGATQATSWTLKERVRFDRRAITSGDWESYPILRFSEA
PEVAVELVEHPGTPSVGAGEAAQGPVAAAIANALAATLGVRVRDLPLDREAVLKAIE
>A0A378YTU1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea pnomenusa|TrEMBL
MASFQLNGKPVKVDVDPATPLLWTLRDALNMTGTKFGCGMALCGACTVHMDGAAIRSCIT
PVSAVEGKKITTIENVGADPVGRAVQDAWVKHDVPQCGYCQSGQIMSATALLRENKQPND
EQIDAAMSGNICRCGTYARIRAAIKDAAASLA
>A0A7Y7HWW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MITLNINGKDVQVDADPSTPILWALRDNLNMTGTKFGCGMALCGACTVHLGGQPIRSCVT
PISAAAGQKITTIEAMETDKVGKAVQDAWVKIDVPQCGYCQSGQIMSATALLRTNKNPSD
AEIDNAMSGNICRCGTYQRIRAAIKDAAKSIA
>A0A846MVF6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizomicrobium palustre|TrEMBL
MLPSQLQDVIESTKTGASRRFFLKAGAATGGVLMLGLYGCAQGEARKNGELNAFVKITPD
NSITIMAKNPEIGQGAKTLLAMLIAEELDADWSHVKIEQADLNTDTYKGQYAGGSMMVTE
NYTPMRQVGAATRAMLIKAAAKQWNVPEGECTTAQSTITHKASGKKASYGSLAAAASGLE
VPELKSVVLKDAKNFTLIGKPTVGIDSPRLVKGAPLYGIDVEVPGMLYAVFQKCPVFGGK
VKSANLDEIKKLPGVVDAFVVKGGSTQVFEAEGGTASTGLLPGVAIVGKSWWQANKARKS
LKVEWDEGPYANQSSEGFAATAKKMFAAAPTLPLRKDGDADAALKSAAKTVSLSFDYPFL
AHVTLEPQNCTAHVADGKCEIWAPTQLPEAARGLVATTLGMELKNITIHMTRCGGGFGRR
LMNDYVVEAAWISRAVGKPVKLLWTREDDIHHDFYRPGGWHKIEAGIDASGKPVAWKHHF
VSFGKANKFASCAGMPPDSYPAGRVPNLTFGASLIETGVPMGPLRAPSENALNWVFQSTI
DELAHEAGKDPLAYQLELLATAEKQPGRLSASRSRGVLEKVAQMSGWGRAVPPRTGLGIA
FAFCHLGYAALVVEAAVAKDGAITINKVWAAVDVGRQIVNPMGAENQCQGGIIDGLSHAL
NEKITFAKGRTVESNFDGHPPLMLAQVPPIEVQFVLTDNRPTGLGEPPMPVIIPALTNAI
FAATGKRVASLPIDPKLLAV
>A0A840H4G9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ERR14|TrEMBL
MNFIDNPGKLHSFEKRGFEKNIKVEKVSRRSILKGLGITGGFVLAAPVMSRQALAYETGA
GKMPHGVVVDPRVFVSVGPDGIVTIVGHRSEMGTGVRTSLPLIVAEEMEADWSRVKVQQA
HGDEVKFGNQDTDGSRSTRHYLIPMRQIGASARTMLEQAAAKRWGVPATEVKAVNHEVVH
SASGRKLGFGELAADAAKESVPSIEGLKLKDPKNFRYLGKGQVGIVDLHDITTGKAHYGA
DVRLPGMKYAVIARPPVTGGKLVSFDPDAALKVPGVEKVLKVQGWPWPSKFQPLGGVAVI
ARNTGAAIKGRDALKLVWDDGPNGKYDSVAYRKELEEASRKPGLVLRKEGDADAALKGAD
KVIVGEYYVPHLAHVSMETPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLGIPEGNVTV
NVTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDIHNGFLHTVSVERIEAGLD
KSGKVVAWRHRSVAPSIASTFAAGTVHQAPFEIGMGLVDMPFEIANISCENPEAAAFTRI
GWFRSVSNIPRAFAVQSMVGEIAQATGRDQKETLLALIGSPRIVKPEVKDLWNYGEPQES
YPIDTARLRKVVELVAEKGEWGRKVPKGHGLGIAVHRSFVSYIATIVEVAVDDKGKLTVP
RVDTAIDCGTYVNPERIASQIEGAAIMGLSLAKYGEITFKDGKVQQKNFDDFQVVRMDES
PVVTNVYIVPPGPDTPPSGVGEPGVPPFAPALINAIFAATGKRIRSLPIGKQLEA
>A2SJZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)|TrEMBL
MSTRFTLNGKATSVDVDPATPLLWTLRDDLAMTGTKFGCGIAACGACTVHVDGQPTRSCI
TPVSMVAGKKVTTIEAVGNDKVGKAVQAAWIEHDVAQCGYCQSGQIMSATGLLKSNKAPS
DADIDAAMAGNICRCGTYQRIRAAIHDAAKRIA
>A0A4P7NXF6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hydrogenovibrio crunogenus|TrEMBL
MQDLMKKASTEDSQDSSVTHTSKNVQVEVIEPENPSRRALLKAGLLGVGGLVLGFNLPSA
QKAYAKTDASTSDSYPVKGWLQLDESGQLAMFIPVSEMGQGSQTAITMIFADELGADYQK
VVVKSPINDSLYNNPIFGMQLTGGSTAVRAWWEPMRVIAATLREMLVESAAKQWQVSAKE
CDVKEGFILHKATQRKIAFQHVIDTAKWVQPPKSPTLKKASEYRYIGKPMHRVDTPSKVN
GTAVFGIDVQLPDMLIATVAQSPVFGGQVDSYDEKAAKSVKGVKGIVKIPHGIAVVADSY
WQAKKGLEKLKPTFKDGETTGLNTDNIEKRLKDGLNKSGESVKSAQAVTDFEHKYEAVYS
APYLAHTTMEPMNATAHVTDSHCEVWAPTQNQAQSAKVAADVSLHQPDQVTIHTTYLGGG
FGRRAFVDYVAQAVTLSMEMERPVKVIWSRPEDIQHDFYRPAAVCQFDVKTDAKGLPVEW
KTKVVSDSTMAEFTNGSDTMIDGAMSEGLADQEYQLPNVSLSVVREDMKIPVGFWRSVGH
SYSGFFLEGMLNDLAQKAGFDPFDYRRALLKPDSRTAGVLNQLEKLSGWKSKSADNIGKG
MAVVESFGSFAGEVVEAHLENGKIKVDKVYCVIDCGMVVNPEIVKRQMSSGIIYGLTAAL
KGKIHFEQGRVQETNFDNYPALTMEESPEIIVEIVQSENGPGGYGEPGVPPVAPALAAAI
SQLTDKVYRELPLKV
>A0A177HU65|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces jeddahensis|TrEMBL
MAVPPLLSKTIDAEFTFAFASNSPLEPDNAIGDVRSDRAETWASLKSPIVAQQEIAAALG
PSQDALTVHVVPGGGSFGRHLFHDVAAEAAEISQKIGKPVKLSWSRTDSFRTRDAPRMRA
ALSAWYGRRGDSRHDNSVIGAAEVTVDMMRQVLDTNVFGVVRVTDAFLPLLWVPEDPGV
>W7WAM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium sp. T29|TrEMBL
MSTRFTLNGKATSVDVDPATPLLWTLRDDLAMTGTKFGCGIAACGACTVHVDGQPTRSCI
TPVSMVAGKKVTTIEAVGNDKVGKAVQAAWIEHDVAQCGYCQSGQIMSATGLLKSNKAPS
DADIDAAMAGNICRCGTYQRIRAAIHDAAKRIA
>A0A509EM01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MIRLNVNGSVHEVEAEPDTPLLWVIREQVGLTGTKYGCGIAQCGACTVHLDGQAVRACSL
PVSAVEAGQKIVTIEGLSPDRSHPVQRAWAELDVPQCGFCQSGMIMAAAALLRQTPKPSE
AEIRREVTNICRCGTYNRVLAGITLAAERGEAGRG
>A0A5B8RH43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured organism|TrEMBL
MAIDLEVNGVARRYDGPPERPLLWYLREDLGLTGTKFGCGVALCGACLVLVGDAAVPACR
TAMGGLHGTAVTTIEGLAARDDPVIAAWRDAQVPQCGYCQPGQVIAATALLRTTPRPSPT
QTEAAMDRVLCRCGTYQRARRALAALTGGRHG
>A0A5B8REF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured organism|TrEMBL
MSTFTVNGKTHRFDGDPQTPLLWYLRDVSRLTGTKYGCGMSLCGTCTVHLDGEPVRSCVT
PVSQAEGKAVTTIEAMSEDAVGRRVQQAWLDLGVAQCGYCQAGQIMSATALLRDNPAPDD
EQINQAMSGNICRCGTYARIRQAIHRAAATQEDEA
>A0A7W6RTQ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium mongolense|TrEMBL
MSIHDKVNLAVSRRHFLIGASLSGAGLVIGLRPSPSCAAAEAFEANAFIRIPAEGKIVFI
MPSVEMGQGIYTSVAMLLAEELEVRLDQITLEHAPADPARYANPLLGDQITGGSLAIRAV
YEQMRKAGATARIMLVNAAAHGWNVAVDTCKAEAGHVVHAASGRRADYGSLIQAAASEPV
PQEVPLKSASSFKVIGQSVRRLDSPEKVNGTAKFGIDARPEGVSYAAIAICPHFGGKLRS
VKDGPAMAVKGVRQVVRIEDAVAVVADNTGAARKGLAALSIEWEQGADGALSLADLEKRA
EEAIGGNALPHINEGDVAKAESQHKPALEFVYRLPILTHSAMEPMNCTVHVRNDSCDVWV
GTQVLGRARQVVADVTGLPLDKVVVRNHLLGGGFGRRLDVDGVILAAKIAKQVDGPVKVT
WSREEDIRHDCYRYLNYSKITATLGADGMPVSWRHRVIGPSVMARWLPAFTRDGIDLDIM
VGAETPYAIPNKYTDFVRHEAPDGMLTGNWRGVGATRNVPAIEGGIDELAQAAGIDPLDY
RRRLLQHKPRLLGVLDLAAEKAGWSTTLPQGKGMGIALLEDFGSFAAMISEVSVGEDGKL
KTDRIICAVDCGQIINPDTVEAQIQSGIIYGLSAALYGRITVQNGAVVEGNFDDSPVLRI
HETPKIEVHIVPSSEAPGGIGEVGTPGVAPSLFNAIFAATGKRLRSLPIDQNELRRV
>A0A087PRR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MEGGLLFGFSTELYEEITIKDGRIEQSNFHNYPIMRINDAPPIDVHITKITENPGSIGEV
GTTAAFPSLGNALFNAIGKRCKRHPFSPHFLMEIVSCF
>A0A1E1VB61|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. BIWAKO-01|TrEMBL
MHDLTINGHSLSVDAPDDMPLLWVIRDILGMTGTKFGCGIAQCGACTVHIDGEPTRSCIT
AISDAAGMSVTTIEAIGATPAGKAIQAAWLNLEVVQCGYCQSGQIMSASALLAGNPKPTD
ADIDAAMSGNICRCGTYLRIREAIKQAAAIAGAR
>A5EGS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MNGRDYEIAAEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPLDSI
GSADIRTIEAIDQDAVGRKVVEAWVTDQVPQCGYCQSGQVMAATALLKQTPHPSEADIAD
AMTNLCRCGTYNRVAAAIRRVAHA
>H1KPK3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens DSM 13060|TrEMBL
MLTLNLNGVAREVDADPDMPLLWVIRDRLDMTGTKYGCGIAQCGACTVHMDGQPVRACQT
RIGDVGEAKITTIEGVEGKVADAVKAAWRGLDVVQCGYCQSGQIMSAIGLLTENPKPSDT
DIDGAMDGNVCRCGTYQRIRAAIHEAARTLA
>R7ZSR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lunatimonas lonarensis|TrEMBL
MKFTINGKEQTVQVEGNPMLLEVFREQLELTGTKYGCGESVCGACKVMVNGSAVPSCITP
AVSVQGKQVVTVEGLERDGALHPVQQVFLEVDPFQCGYCASGMLVTAVAFLDKNPSPSRE
EIVDAMNGNICRCCTYPAIIEAIYQASRKMA
>A0A1Y5S102|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Palleronia marisminoris|TrEMBL
MTEQFTLSRRGFLASAAATTGGLAIGFPLGAGAQQLAGLAEPEMNAWVVVQPDNTVIVRV
AKIEMGQGTLTGLVQLVAEELDADWETVSWSYPSPGENVARERVWGSFGTFGSQGIRTSQ
EMVRQGGAAARAMLMQAAANRWNVDVAELSVERGVITGPGGETLTYGDVAEDAAKLDVPE
SVTLKDPSEWTIAGQSLLRLDTAGKTDGSLVYSIDFAVDGMVNAAIRQTPVQGGTVASFD
ASTVEDMPGVMRVIQVDESTVAVVADTWWRANKAVEALEIEWDLPEEAASFGTEELEAML
NDGLDADETFVGNETGDAAQALQDAAQVVEATYSYPWQHHVTMEPMNAMALVTDDSCTVW
TSTQNAESDLAAASEASGLEIAQCDIHRMHLGGGFGRRGASSTDYTTLAVKIAMEMKGTP
VKVIWSREEDMTHGTYHPVTKARLRGGLDAEGNLTGMHMRISGQSIFAGLMPYALEDGMD
PLVFQGLQPEGEEGRLGYTVPNLLIDHAMRNPPLRPGFWRGVNNNQNSFYLESFIDELAL
AADRDPLEFRRSMMQDHPKHLAVLNKVAEGIGWEEGPPEGRAYGLCQHMGYGSYVAAAAE
VSVENDAVKIHRIVAATDPGHIVNPQQVEAQIEGSFAMGLSASMLSEITVEDGRVQEQNF
DTYPIMTMWEMPDVQMHLVPSGGFWGGVGEPTIFVATPAVLNAVARLTGKRVRELPLYRS
GLRLA
>A0A0A0BFR9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylophaga thiooxydans|TrEMBL
MKLTINEQVHELNAPDEMPILWALRDVLGMTGTKFGCGKSLCGACTVMLDGNPIRSCVTP
VKAAENKSITTIEAISEQKTGQAIQNAWIENNVPQCGYCQSGQIVSATALLNANPQPNDE
DINNAMSGNICRCGTYNRIRDAIKQAANKLETDHEG
>A0A7X0PAX9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MPTLHINGKETVVDADESTPILWALRDTLGMTGTKFGCGAALCGACTVHLNGAPIRSCIT
PISAAAGQKITTIEAIAANDKVGKAVHAAWVKHDVAQCGYCQSGQIMSATALLKGKKKPS
DADIDTAMAGNICRCGTYVRIRAAIHDAARSLA
>A0A1U7D9A5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MSIKLSINFSNVTVDADPDMPLLWAIRDKLGLTGTKFGCGVGACGACTVHIDGVAVRSCQ
TPVGDVGDGKITTIEAVSGKTGAAVQQAWAEMDVVQCGYCQSGQIMQAVGLLTENPRPTA
QEIEDGMWGNVCRCATYQRIRAAVARASDILEA
>A0A5P9H4M4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. THAF27|TrEMBL
MSRAGKIARRSFLVGAVAAAGGVAFGVWRYRTPYANPLLAGLNDGEAALTPYVLIRPDGI
TLITPRADKGQGAYQVQAMLLAEELDVRPDQVSVDPGPPDVAYWNRALAEETAAFLVPGD
GLAQDAAETVVSAASKFLGLQITGGSTTTPDGFDKLRAAGASARETLKAAAARATGHAVD
TLSTRDGAVLLPDGSKLAYTDLAAQLAEIEPVTDVALRQPSEWRLIGHATPRLDMVAKST
GTQGYGIDVELPGMVHATVVLNPAQNGALGSYDTGETFKIPGVQSVVEITGGLGVVADTT
WTAFKGARALAVSWPDGPVPPNMDDHWQALSDSFDDDALDSRKRDDGDVEAAIAARAGNV
IEAEYRAPYLAHAPLEPVNATVRVDEDSVEIWTGTQIPRFVLANVARITGVAEENITLNV
QMIGGSFGHRLEDTVVRHATEIAMEMRGTPVKLTYSREEDMTHDFPRQIAMGRMRGTVRD
GRVEAFELGIAMPSVILSQMARQGQSVPGPDSQIVAGAFEQPFALPHQRVTGYRAPLLAP
ISSWRSVGASTNGFFYNAGLDELIHAAGADPLEERLRLCNDPLARAVLEAVGEMSDWTGP
NLGDGVGRGVAFTKSFGVPCAEVVEVETTQSGLRIRRAWVAAEVGTVVDPLNFENQVAGG
VIFGLGHAMNCEITYADGRAEQQNFDSFQAMRLYQTPRIEVRGLENGDRVRGVGEPPVPP
AAPALAAAIFAATGTRLREMPFSKFVDFA
>A0A840ZET2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodinum|TrEMBL
MLKLDLTDAPVPSRRAFLGGAAAGVVLLAFRLDLRGARAAEGGGPDLSKGPAQPNAFVRL
SADDTVTVMIKHLDMGQGNTTGLTTIVADELDADWAQMRAAFAPADAKLYANLLMGPVQG
TGGSTAIANSWFQLRKAGAAARAMLVAAAADKWGVPASEITVAKGLISHKSGKQGRFGEF
AEAAAAKPVPQEPRLKAPSEWTLIGKGVPRLDSPAKTDGTAIYSLDIRRPGQVTALVAHP
PRFGASVKKVDAEAAQGMPGVVAVVTIPSGVAVIARDTWTAMKAREALKVEWDDSAAETR
SSDAILSEYRETAKTPGLVASQAGDADAAIKGAAKVVEAEFSFPYLAHASMEPLNATIER
AADGSYDVYAGCQIQTIEQAVVAATLGVTTDKVRLHTLWAGGSFGRRATPGADYFAEAAS
IVKAWGGKAPVHLVWTREDDMAGGYYRPQVYHTVKAGLDAKGQVAGWRHTMVGKSIMIGS
PFEAMLVKNGIDGTTVEGASDTPYGLPAYRFEVHNAREGVPVLWWRSVGHTHTAHVMEVM
IDELAHAAGADPVAYRLSLLTRAPRLSGVLRLAAEKAGWSEKPTAKGRGLGVAVHQSFGS
YVAMAADVTAGESGVKVERIIAAVDVGIAVNPDVVRAQVEGAVGFALSSVLRNRITLKDG
VVQETNFDSYQPTRISEMPRVEVHIVPSDTAPTGIGEPGVPVLAPAISNAIFAATGQRLR
SLPLDLASLRGA
>A0A3B0SZQ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MLTVKSNRREFLLSAVATAGTLTLGVSLTGYAQEDRRSNSPVARTFNAFISIADDDSITI
QVPCSEMGQGVFTALPMILAEELNADWEKITAQTATADKAYHYQTGWDQQITGGSNAIAG
WYAVLRKVGAAAREMLTAAAAETWGVAASECVTEKSMVIHSATGRTLGYGTLVEAAGKRP
VPENPELKSEADFNIIGQPKARKDTPAKVDGTAIFGIDVMLPDMLIATVKTCPTFGGTVK
DYDADAAMNMPGVHMLVPVPGGIVVVADTYWQAHKALEVLNITFDAGPNAGQNSGKIAAV
LTAGLDEEKAIPAKEEGNVQEALTDSNNTVMTAVYEVPYLAHSCMEPMTCTADVRPDFCH
IYAPTQWPTETRNIASKITGLPLEKVRADVTFLGGGFGRRGEVDFVEQVVLASKAVSRPV
KLIWSREEDITHDFYRPTSLTRMTAAINKKTGDAVAFDCRVVAPSILARAANLPPGVLDG
AAVEGLSDQPYSFQNVRVNYVRKDLGIPVGWWRSVGNSQNAFVRECFIDELAHMQGEDPY
EFRRRHLGDEKRHLAVLELAANKAGWGKPLAKGHHLGIAVAMSFSSYVAEVAEVSVKADG
SIKIHKITCAVDCGVVINPSIVRTQVESSVIYGLSAAVDGEITIQNGAVEQSNFHDYPAL
RLSETPDIDVHLVTSSEPPTGIGEPGLPPLAPAVTNAIYAATGKRIRSLPFIKHGLTVI
>A0A143PM61|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteitalea pratensis|TrEMBL
MKYSVLVNGEPRAVDVPERMPLLWVLRDSLDLKGTKFGCGAAQCGACTVLLDGQPIRSCI
TPISAVGKAAVTTIESLPRDGSHPLQRAWLDLDVPQCGYCQAGQLMAASALLKATPNPTD
AQIDAAMSGNVCRCGTYMRIKQAIKSAAGAGGRA
>A0A143PNF1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteitalea pratensis|TrEMBL
MATTLKDQGLDRRAFLQISAVAGGGLLIGLSTPHVAAQGRPGGPGASAESLAPNTYITVH
PDNTFTLIAKNPETGQGIRTALPQVIADEFDVDWAQVKIQQADLDPKYGAQFEGGSRAIP
SNYQNMRLVGAGGRLVMLAAAAQQWGVPTSELTTKAGVVTHTASKRTATYASLSALAATL
PVPEKAAIEAGLKHPRDFTIIGKRIRGVDNLDIVTGRPVFSIDVAFPNMLHAVLVKCDVF
GGKAISANLDEIKKLPGIRHAFIVEPATGQGNNSLASGVAIVADSWWLAHDARSSLKVTW
DEGAVATQSSTGYLAQARELAARAATAPLPAPTPAPAPGERPTGPPRAVIGDVDAAFRAA
AKTIEAEYFFPLLSHAPLEPQNSTAHFHDGKLEIWSPSQIPSKQHPALGAGIPPENVTFH
LVRAGGGFGRRLVSEYDVEVARIARTVTEERAAAGQPSVPVKLLWSREDDLAHDQYRPTG
FHFFKAGLDASGKLIAYRDFVASTNSVVPANEFPRGFVENVLITSDNVTPFGIPVGALRA
PPTNGISFVKQGFIDEVAVAAGKDPLQYRVDLLNNPVGAGATGGFNPVRARGVLEAVRAM
SEWDRRGSLPKGTGKGVAFQFAHAGYVAYVVEVSVDAQKAIKVNRVWCAVDIGRQIVNPS
HSENLVQGGFIEGMSHLMSWAITIEKGRVVQKNLHQYQPARMPHAPASIEIKFLETDFDP
TGLGEPSLPPAVPAITNAIFAATGVRIRSLPLEEQGYRWT
>A0A7S4H3P2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia sp. Tan611|TrEMBL
MKRRDHDLTALDEQPVNLSRRRFLLAGGSLAGALVLGVGLPIGQSRAQAAEAVLAPGTRV
PAFLEIRPDSSVKFLSPFIEGGQGIFTAMAQIVGEELDADPATFIVENAPAGSQYQVMEG
GMRITGGSQSVRASYTTMRRLGALARQMLLQAAAAELSVPIDQLQTEPGRVIHAASGRSL
SYGELAARARDLSVPSPDSVTLKDPARFRWIGKPVQRLDMHEKSTGKAVYTIDCRVDDML
HAAVQHAPRLGLHAGKLRNEDKVKAMKGVHSVHVLPGAVAVVAERWWQAKRAAEALQVEW
LEPDAPDGNYMPADFSSEAFAAVLAQEPGKGENAEVKGDIAQGMSAAETTLNATYHSQYL
NHAQLEPPSALARFNNDGTLELWIPNQAPEMFQADVAKRTGLAPEKIIIHSPLLGGFFGR
HFVYDTAMVYPQAIALAKAVGRPIKLIWSREEEFLRDTHRPMAAVRFRAGLDAQGYPVAL
EAVSICEGPTEGQAGKHGEQLDPTALEGLTGKAYAIPNVRIAQIYKKGPVKLGYWRSVGN
SMNDFLYECFLDEIADKSKLDPFALRLHLLKGNQRLTTLLNTVAEMSGGWQAGPYTASDS
SRRARGVAMASPFGSEAAAIAEVSIENGQVRVHQVWEAIDPGSIVNPAIIEAQVNSAVAL
GLSQVLLEESVYEKGQPVARNYDMYPILPPSRMAPVQVRIVESGAKMGGIGEPPLPAIPP
AVANAVSRLTGERIRSMPLSRFNFS
>A0A841MLS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MTLVDKKLNRRSFLKVSTLAGGGMMLSFSWLAGCKPTPEEVLTMPKEWFELNSYIKIGEN
GAVTLFNPNPEFGSNVKTSLPMILADELDVEWKNVFVEQADFYPERFDRQFTGGSQGIRS
GWMPLRTAGATARQLIVNAAAQTWNVPAEEISTNAGFVEHQTSGKRASYGEMASLAGTLE
APDPETVKLKDISDFKIIGNSKKNVDGTKIVTGKPMFGIDHKVEGMKYAAIVQPPAFGMQ
LKSFDKSSVTSMPGIQDAFEVKIFKDDYGRNFFDTTTFPTIIAIVGNSTWEVMQAKKNLK
AEWEEAPDSTFPMAGRGGQNMDIKVPGGLENSETHKVKMAEYISKPGNVLRKDGDPEGAF
KKAAKVLERTYTAPFLAHNTMEPMNCFADVKGDKAVIYGPTQAPELIRQTIAASLGIPQE
NIQINLARMGGGFGRRAYSHHMTEAALISQKIQAPVKMVYTREDDMSAGVYRPTYSATYR
AALDDNNNLLALHVKAGGIPESPIHANRFPAGAIDNYLAEGWQIESNITIGAFRAPRSNF
IAGAEQSFLDELAEEMGKDPIEFRLELLKRAETNPVGENNDYDPKRYAGVLELVREKSNW
SNVPAGISRGVSAYFCHNSYVAEVVDITIKDKQPVVENVYAAVDCGIVVNPDAAANMGEG
AIVDGIGNAFYGEMAFENGAPTKRNFDTYRMIRHKEAPKKIEVHFVQNNEAPTGLGEPLF
PPVFAALGNSLYKATGKRLYEQPFQPQLLEMENLKM
>A0A108UBS1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lysobacter capsici AZ78|TrEMBL
MKLNVNGTEHEVAAPPDMPLLWVLRDLMQLTGTKFGCGIAQCGACTVHVDGSPRRACVTP
VASVEGKQITTIEGLSKDGSHPVQRAWAEIDVVQCGYCQSGQIMSAAALLTKIPAPTDTD
IDQALSGNICRCGTYPRIRAAVKRAAEIGKA
>A0A839U2J4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MSHNLMVNGNDYAVDVDDDIPLLWVLRDTIGLTGTKFGCGIAMCGACTVHVDGMPVRSCI
MPVAEAVGKPVTTIEAIGDTAEGARIQKAWLEIDVVQCGYCQSGQIMSATALLAANPSPT
DDDIDAVMAGNICRCGTYPRIRAAIKQAAKAG
>A0A6J5BVA9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia phenoliruptrix|TrEMBL
MGSLNINGQAVAVQVEPDMPLLWVLRCELGMTGTKFGCGVGICGACTVHLNDKPFLSCQI
SMSDLNTQKITTIEGLQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKEKPHPTDA
DIDAAMSHIVCRCGTYPRVRAAIHQAAKRRPA
>A0A1Y5T686|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseisalinus antarcticus|TrEMBL
MWAATEMPAAVRDAAVEITGVDPARVTLNVLPAGGSFGRRLDPDSAAQAIQIAVTMPGTP
MKATWSRQEDMTHDNPRPLHMALGRGTVADGRVLAQDRDNIGPSLIPSSWGRASSPRRAS
ARAMPASMTLDVA
>A0A679JHI7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax paradoxus|TrEMBL
MKPAAGTAGINRRSALQAGGLALAFTWIGGSKAFAAISPRRQPADAAAALADGNPPFAPN
AFIRIDADGGVRLVMPMVEMGQAIYTGSAMLLAEELGVDLDQVRVEHSPPNEALYGMPLL
GGQITGGSTSTRGTYGVLREAGAVARTLLVSAAAMQWKVEPASCTVARGVVSHAGSGRQL
GFGALAASAAQLPMPEKVALKEQKDFRLIGQPLRRVDSAGKVDGSTQFGLDVRVPGMKVA
TVRACPTLGGVLASVDDKAARAIPGVIDVIRIKDAVAVVGEHFWAARKGLDALKIRWTPG
QNAALTTRQLRSALAGALASGKAIVGKETGKRPEGTLVQATYDSPMLAHATMEPLNTTVH
VRPDACEIWVGTQVPARCVGVAAKITGLAEDKVVLHNQYLGGGFGRRLETDSVEQAVAFA
RQVPYPLKVVWTREEDIRHDIVRPMYHDDISAVVDGDGRILWFGDRIAGGTVLGRWAPAF
MGKDGMDGDLIECVAEPCYDLPNLKVEWVRHDMPPGLNVGWWRGVGPTHNLFVMESFIDE
LAHRAKTDPVAYRRAMLGKNPRTLAVLDLAAEKIGWGKGTLPARVGRGVAVGDPFGSRVC
AMVEVEVSPQGEVRMRRAVVAIDCGLVVNAGSVEAQIQGGLLFGLGAALFSEVTLRDGAI
EQSNFHDYRMLRINESPPVEVHAVRSSEAPGGIGEVGTAIAAPALANAIFAATGVRLRAL
PVNRALLAQDKDALKKKVADASIGGRSERSAA
>A0A6J4MDJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Microvirga sp|TrEMBL
DRAFHQRDEASGRWRSRHAAALGGARSPRPDRHQIRLRRRPVRRLHRACGRRRRPLLHHA
RLRRRGDAEDHHHRGPLARWQPPAAEGLGGARRAAMRLLPVGDDHGRGGAAGRQPEAERC
RYPRRDHQYLPLRHLQPRPGRHQAGGRRQPGQWL
>A0A2N9AJ47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens|TrEMBL
MTAMIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHLGGTAARA
CITPVSAAEGQEITTIEGLSPDGNHPVQVAWRDLNVAQCGYCQTGQIMQAASLLKDSPKP
TDQQIDENMSGNICRCGTYPRIRAAIHQAAGQAPATKGDRL
>A0A7U4E443|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MSSKSTRRDFIKASAIAGGGFLLSFRWTDAPASPLTGSAAGEVSFNSYLSISPDNVITIL
SPNPEVGQNIKTSFPMIVAEELDADWKNVKVVQANLDTQKFNRQATAGSGAMQHSWDRLR
KAGATARQMLMEAAAKRWNVSSASLTTENGYVWHKETGRKLNYGALATEAAAMPVPTEVK
FKEKKDYKLIGKPIHNVDNAEMITGKPLYGLDIYREGMVLAMIERPPFGTKIKSVDTAAA
KAMPGIVDVVVFKDKVAVLGKSTWQVTKARKVLKVEYEPDGTVESTTDHERLMKQLLDKE
DVKPSRKDGDVDAVFKTAAKVITREYRAPFLSHACMEPMNFFAHVRNDGVELIGPAQLPE
DTRKNVAKLLGVDVEKVALQMTRMGGGFGRRQRSDYSMEAAELSSRVKAPVKVMWTREDD
MRGGQYRPAMHYRFQAALDAEGNWIGYRMRGVGINSGNSTRPDHFPAGAVPNFLVDSIDH
KSPVTTSPWRAPSENFLGFAEQSFFDEVAEAAHRDPIEFRLAYLDKAKKSPVGAVKYDID
RMKGVIELVAEKSGWGKNKKVFQGFSAYFSHGSYIAQVAEIEIQQGKPVLLKMVAAVDCG
VVVNLSGAYQQVKGGIIDGLGHALYGEVTLKDGVPDQKNFDTYRLIRMKEIPDVEVYFVD
SAINPTGLGEPALPPAAAALANAFFKATGKRLYNQPFTKEEAMKGGKLGGK
>A0A518L6L2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Planctomycetes bacterium TBK1r|TrEMBL
MNTSIQSRKGISRRGFLAGASAGSLVLMAKVTGGQEVVVVGATKANLESFDPDLFVSIAP
DGIVSILAHRSEMGTGIRTSLPRVVADELEADWERVEIVQAIGDKRLGDQNTDGSNSIRF
FFDRMRVAGATARTMLERAAAQKWGVPVDQCKADNHRVVHSNSDREIGFGELVSIASTLD
VPAADELTLKPASKYRYIGKDTPITDMDDILTGKAIYGIDARMENQLFAVIARPPVVGGT
VKSFDASEAKKIPGVVDVIEIPKFVGAPLFQPLGGVAVCADSTWAAWQGRDALDIQWDDG
PNANYDTDEFAKTLAAAANQPGKAVRNHGDADKVIAESDNVLRADYSVPHLSHAPMETPC
AVADVKTEGDKVVSCTVTAATQNPQAVQQAVGPAMGMKPEDVIVNVTLLGSGFGRKSKPD
YCVEAAMLSRKLGRPVHVTWTREDDIHNDYFHTISHVHLEAAVDDDGKPNAWLARAAYPT
IGSTFNPFAKEPAGFEVEMGLTDCPYDIPHLRVEVGQAAAHTRIGWLRSVAHIQQNFAVC
SFADELAHHAGRDPYEYLLELLGQDRHLDLKAIGLSNRGASPTDYPYDIGRLKAVTRRAA
EMADWQRGKQLPKGRGVGIACCRAFLGYTGHVVEVEVSQDGKLRIPKVWVALDAGLIVSP
DRVRAQVEGAAIMATTQARYGKITFKNGRVQQSNYDDYSMVTMSDAPREIIVDVIDSKAA
PAGVGETTVPSFAPALCNAIFAATGKRIRDLPLRDHDLSWS
>A0A1E3GWT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MPLVTRRGLLLTGAAVAGTALVTAVAGVGYLATVDVDGLAGSLDGEDAHLNAFVVVHPDG
RVVVNVPRAELGQGIHTGLAMLVAEEMDLLLDDRVTVVFPTEAHPAYSSWFNMLQVRPEE
ASGPVVWLGRRLLGELGFIATGASASTMSLWHPMRVAGAAARAMLAEAAAVRLGVPRADL
RTADGRVHHDASGGASPMANSPATRRCWLRPRHRR
>A0A5P9IN20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas sp. THAF5a|TrEMBL
MASFTLNGEPVSVEVSPQTPLLWVLRDHLGMTGTKFGCGIAQCGACTVHLDGSATRTCVL
PVSAAEGAEIVTIEGLSADDDHPLQQAWRELQVPQCGYCQSGQIMQAADFLSRNADPSDA
EVTEAMAGNLCRCMAYRRIHRAVKRAAEISQAREADTAGVGVFDPARAQEVTHGQV
>A0A839XLH4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella sediminis|TrEMBL
MPAHRADPAEPDAVSPDTSFSKEPTSRRRFLGYLLAAPTLVAAAELGGGTGFGAPAANAA
ETGAGVPPSPQLADSYDLTDALVHAARPTANLITITLDENGHAHFELHRTEVGQGINTTV
AMLIAEEMDLPLDHVHVTLADARPELMTNQLTGGSSSVSSIYYPVRTAAAIAKGKLLEAA
SLVLGEQANFLSSKLGVITSRAGRSVSYGDLATKAASDSTKQVEANLKAESDFAIVGKPT
RRIDALDAVTGRKQFTTDLDVPGAKPTMVCRPPTINGTPQSVTNAEQVRRMPGITDVVTI
SSGVAVRGETYGQCIDAVNALDVKWSPGPVDGESDATVEQKLKDATPPAVIPPTPATKTL
ERQFTFAFVNGSALGVNAAIADVKPDSAEIWSTLKIPIAAQQNIAQALGMATNQVTVHVV
SGGGSFGRALFHDAALEAAEISQKIGKPVRLMWHRADDCRQGRVHPMSVGTIRASFNGDV
VSFEQHLASVRTDFSHGLGDAVSSTVARELPGVSYTVSEAIFALTTPSLYNFGITKTLLT
ETHQSPENNRPRGGFNTGSTRNVYSPDVVTTRELFVDELAEKMGMDPYDFRRKYVKNESL
LKVLDKAAEVGGYGKSTPGGVGHGIALHHEYKQTMACFVELDCRPETVNRKVRDGVTGPR
VTRGVLVTIPGHIVINPLGLEAMMQGGFIDGFAQALTASVHLNNGRIAEASWDNFFYCRQ
WNLPFEFTPVVLPAEESEIPAGAGEMGVAPSFAATACAYRAATGKTPTHFPINHNDPLPF
EPYPHEPPLPPSPTNGLDYAY
>A0A2X1GJJ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cepacia|TrEMBL
MSRGLIEAGKVAGQAAGAGVSRRSFLKLGMSLGAAAGGGLLLGFSLPAAGDDARRSVIGG
DGDETARAGVFAPNAFVQIDRAGKVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLD
HAPPNEKLFLDPLLGGQLTGGSTSIRYAWEPLRRAGATARTLLVVAAAKQWNVDPASCRA
VNGEVQHPSSGRRVSYGQLADAAAKLPVPKDVALKKPADFKLIGTPAKRLDSPEKVDGTA
QFGLDVRLPGMLYAVIVNSPVFGGTVASIDDTAAKKIPGVRQVVRADNAVAVVGDHTWAA
KRGASALVVKWNEGAGAKVSTKDIVADLAQAAANGKGAVARKDGDVGKGFADAKTRVDAV
YEQPLLAHATMEPVNCTVHVRADGCEIWVGTQVPTRAVDTVQQLTSFPPEKIVVHNHLLG
GGFGRRLETDMIGQAVKIAKQVNAPVKVIWTREEDIQHDMYRPYYYDRISAGLDANGKPI
AWQHRIVGSSILARFAPPAFQHGVDPDAVEVATDLPYDLPNQLIDYVRQEPRHVPTAFWR
GVGPTRSTFVVESFIDELAAQTKTDPVQYRRALLGKTPRALNVLDVATKAAGWGPSLPTG
QGRGVSVMHAFGSFFSIVIDVAVDNGEVQVKRVVCAVDCGMSVNPNTIEAQVQGGIIFGI
TGALYGEITIEDGRVVQSNFTDYRMLRINETPPIEVHLVKSGEAPGGIGEPGTAATAAAL
SNAIFAATGKRLRKLPVGDQLKTA
>A0A7W5IHJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WP4_3_2|TrEMBL
MVEIVINGQHHQFDGDPEMPLLWYLRDELGLTGTKFGCGMALCGACTVHLDGQPARACVT
PVGAISGRSVTTIEAVHEQKVGAAVQAAWIEKQAPQCGYCQSGQVMSAVALLKTQPNPTD
AEIDDAMSGNICRCATYQRIRAAIHEASEALKHA
>A0A839P6N5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium sp. R2-1|TrEMBL
MTAMIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHLGGTAARA
CITPVSAAEGQEITTIEGLSPDGNHPVQVAWRDLNVAQCGYCQTGQIMQAASLLKDTPKP
TDQQIDENMSGNICRCGTYPRIRAAIHQAAGQAPATKGDRL
>A0A0S2I257|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinivirga cyanobacteriivorans|TrEMBL
MITFVLNNQIVHTDKAEGTALLDFIRDDSSLPGTKIGCREGDCGACTVLEGTLKDGRVLY
KSIVSCLTPLGNAHGKHIVTLEGINMNDLTPVQKAMVDNAATQCGFCTPGFIMSFTAHAM
SHQKVNAKGAIDAVSGNICRCTGYKSIERAAQANAEAMQNKDLKEPVKWLVEKHYLPDYF
LKIPKMLREIESPDIEFDENHKIMGGGTDLLVQQHDKIAESPINRFYLKDDLKQITVANN
RVIIGAGCTANDIALSELMQDFFPKIKEQFKLISSEPIRNTATVAGNIMNASPIGDLSIF
FLALNASVILNNKKQQREMPLKEFFLDYKKTAIEQGEFIEAIAFQKPEKGVLVNYEKVSK
RTHLDIASVTSAMKIIVEKGIIEACSISAGGVKAIPLFLNKTSEFLTGKNLTPEVIQKAN
EIMQTEIAPISDVRGKSEYKRLLLKQILFAHFMELFPGHVAKEGLLR
>A0A839P2H8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium sp. R2-1|TrEMBL
MIHEAKLMAELAASQNTAGPVRIDNFSRRGILGGMGALVLALSLSDRAKADEGQTEEQKA
KKFGADGMPNGWRDDPKVFVAIAKDGTVTVTNHRSEMGQGVRTSIAFTVADELEADWSKV
KVVQAWGEETHFGNQDTDGSRSLRHFFQHFRHAGAAARLMLIQAAAKQWGVPAGEVKAEN
HVLTHAKSGRTLGYGDVAEAAAGLPVPARESVQLKKPEAFRYIGKGKIGLIDNRDITTGK
AIYALDVKLDGMLYAVVARPAVYGGKVVSVDDTEAKKVPGVVKIVKIEGGEIPSEFMPLG
GIAVIAKNTWAAMKGREALKITWDDGPNASYDTDAFRKELEKAARAPGKVVRVAGDVDAA
MKTAKAKFEAEYFVPHLAQAPMEPPAAVARFKDGVCEAWACTQGPQAAHDRVMKRLNLPA
DKVRVNVTLLGGGFGRKSKPDYVVEAALCSQAVDGAPVKLVWTREDDIQHSYYHTISVER
IEAGVDDKGMPVAWLHRSVAPTIGSIFAPDPKHELPFELGMGLVNNPLALKNLRFENPEA
SAHTRIGWFRSVSNIPHAFAIQSFVAELAHAAGRDPKDYLLELIGPARKIDPTEIGDVWN
YGEDPKRYPVDTGRLRRVIETVADGAKWGRKLEKGRGLGIAGHYSFVTYTAVAAEVEVDD
KGQVKVHAIDIAVDCGPQVNPERVRSQMEGAVIMGMGLALTSKITFKNGRAEQTNYDGYE
VIRIDAAPKVVRVHLVPSNDYDSPLGGVGEPGVPPVAPAIANAVFAATGRRVRELPLRDQ
LST
>A0A1W5DJW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia proteamaculans|TrEMBL
MITLIVNDQPLTFDGDPHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAEGKKITTIEAIGETPTGKAVQAAWVNLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMSGNVCRCATYVRIRAAIHQAAKALD
>A0A5E6YYX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNVRIDPSLQASALDLREPINVSRRRFLTGTAVGALVLGFGLPLGTTRVQAAVAAATAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPSTFLVEAAPPGEAYV
VLENGMRITGGSMSVRMSYPVMRRLGALARAMLLQAGAQQLGVPVSELSTEPGKVVHAKS
GRSLAYGELAERAMDLPVPDPASVTLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKV
DNMLHAAVQHAPRLGMTVGNLRNEDQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTAESKVRPMPADFSSDAWFKRLAEDKGPAKDDENEGDVAAILKETKTRIDATY
HNQYLNHGQLEPPSALARFNPDGSLEVWLPNQAPDMFRADIAKRTGLDISRITLHSPLLG
GFFGRHFLYDSASPYPQAIALSKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRGALDAEG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFDLRLHLLRDNKRLTTLLQAVGELSGGWKRGPF
TAEDGSRRARGVAMASPFGTETAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEEAVWIDGKPRARNYDLYPILPPARMARVHVRVVESGEKMGGIGEPPL
PAVAPAVANAVARLTGQRVRSLPMSRHTFT
>A0A448DZR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHSLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQNVTTIDNLHADPVGQVVQQAWLDSAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASSHLKEVKA
>A0A5E7DIR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MTRTIENESRRRFLKGTAGLTLAVYFPWAMAKSPDAGQVQASVFEPNAFLRIAEDNSVTV
VAKHLEMGQGSYTGLATIVAEELDAAWSQVRVESAPADASRYNNLKWGPSQGTGGSSAIA
NSWEQLRKAGASARAMLVAAAAQRWQVPAQEIVVADGVLRHPASGKEASFGQLASAAAEQ
PVPEQVSLKEPHDFKLIGQPLHRKDSAAKINGTAVYTQDIHLPDMLTAIVAHPPRFGAVV
ASFDATQALAVNGVVEVVQIPTGVAVLARDTWSAKRGRDALSVQWNESAAFSLGSKQIFD
QFRKLAESPGAVARQEGNADTALAGAKQVLEAEYDFPYLAHAAMEPMNCVIRLTADGCEA
WFGAQMQTYNQGLLATLFGLKPEQVRINTLYAGGSFGRRASKDGDYILETAHIVKAIGGR
APVKLVWLREDDMQAGNYRPMFHHRLRAGLDPQGKLVAWQHRLVGQSVVAGSPFAGAIKN
GIDPTSVEGAVNLPYVIPNMLVDLHTVSDIAVPVQWWRAVGSTHTAFSTECFIDELAQAA
GHDPVAWRLSMLQAQPRHAAVLKLAAKKAGWNTPLPKGKEGERRGRGVAVHEAFGSYVAQ
VAEVTVQTDGRYRVDRVVCAVDCGIAVNPDVIRAQVEGSVGFALSAAMSEAITFTGGKVD
QSNFHNYPPLRIADMPRVEVHIMPSTTAPTGIGEPPVPPLAPAVVNALAAATHTRIRRLP
IGNQLAS
>A0A0B7D9V1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSLLDDSCAELPRRVFLKQAVTVASGLAIALYLPSGMAATDPKAPAPASEFEPNAWVRVL
PDGTVKLVVHKHDSGTGTHTALAACVAEELDVNPMTVQVITPEDPFFETYIHPIWKVFST
GGSTSVSLEYDRLRMAGATARALLITAAAKQWKVSPESCSTEEGRVLHPSSKRSLGYGEL
VGVAAHLPAPDKVTLKDPSQFKYIGKLRHKRDAAAKVCGQFRYSIDVQLPGMLVAVIQXX
XXXXXXXXXXXXARKWSAWARQQRYGCPACAK
>A0A5E7IVH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGATATGALVLAASWGWQDALAEDKPKQFGADGMPNGWIDD
PKVYVSIATDGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPLGECHAQLHKVIHKPSGRELGYG
ELAAAASALAVPARDSLRLKQPSEFRYIGKEGTKAIDGDDIVKGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSVDDSAALKVPGVIKVMQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSSAASSLEASYYLP
HLAQAPMEPMVAIARFNNGVCEAWAPSQAPQVTRERIAERLGLPFDNVTVNVTLLGGGFG
RKSKPDFVIEAAILAKEFPGKAVRVQWTREDDVHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEARVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGVDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RAVLETAAKAAGWGRQLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E7BVG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSFLDDSGAELPRRVFLKQAVTVASGLAIALYLPSGMATDPKAPAPASEFEPNAWVRVLP
DGTVKLVVHKHDSGTGTHTALAACVAEELDVNPMTVQVITPENPFFETYIHPIWKVFSTG
GSTSVSLEYDRLRMAGATARALLITAAARQWKVSPESCSTEEGRVVHPSSKRSLGYGELV
GVAAHLPAPDKVTLKDPSQFKYIGKLRHKRDAAAKVCGQFKYSIDVQLPGMLVAVIQRAP
VVGAKVVNVGSAATLRVPGVRKVIAIPGRPDVLGGNLEGVAVLADTYWSAQEGRKLLEIQ
WSDSALAGFDSDQLFSAQAKAIGDPQSQVVNAMTTGDVAGQWAGAAQLLEADYIMPYKVQ
NPLEPICITAQVKDKAITYWGGVQVPSSALEAAQTVCGIDKANVTIHELVSGGSFGAREA
KYWLFEVAYLAQKTAVPVKLLNSREDEMHALFYHPATLNRIKGALDAQGKLTALQLHAVS
PASPEQWEPGYFQRPDHMDYSTTEAITAWDFAYRPPHLQLNWVKHESNVPSGWYRSVSFI
PNVFAVESFMDELAHAAGADPLAFRLANMQERPRHVAVLKQAAERAGWGQPLPPGTALGI
ATNQGYTSFIAVVARVTTVDGKSRVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHALF
DKLDIKQGRVVQSNFHDYRVARMSDMPATDIVVLDGEPSKPGGVGELGSPSVVPAIANAL
FALTGVRQRSTPLSLG
>A0A5E7UUL3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQNVSTIDNLHADPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A0D0R7G7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNTPIKLPQGLLDLASGEPINLSRRRFLTSTAVGALVIGFGLPLGSARVQAATSAAERGT
QVPAFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVESAPPGEAYVVM
ENGLRITGGSMSVRMSYPTMRRLGALARAMLLQAAAEQLGVPVAQLTTQPGRVVHTASGR
SLGYGELAGRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYCIDLKVDG
MLHAAVQHAPRLGMSVGSLRNQAEVQAMQGVHSVHVLPGAVAVVAERWWHAKRAVEAIQV
DWQEAPADSTVRVMPADFSSDKHRDFLAAQQGPARDDENEGDVAGALAGAKTQVQATYHN
QYLNHAQLEPPSALARYNPDGTLEVWLPNQAPDMFRDDIAKRTGLAADKITLHSPLLGGF
FGRHFLYESANPYPQAIELAKAVGRPIKLIWTREEEFLRDVLRPVAVVKFRAGLDANGLP
VAIEAVSATEGPTEALAGKQGEKIDPTAMEGLSGKAYAIPNKRIAQIYVKGPVMLGYWRS
VGNSLNDFFYEAFLDELADKGGQDPFDLRLHLLRDNPRLTTLLQAVGELSGGWKRGPFTA
EDGSRRARGVAMASPFGSHAAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIIEAQVHGA
VALGLSQTLVEEAVYVDGKPRARNYDLYPVLPPARMARVHVRIVESGEKMGGIGEPPLPA
VAPAVANAVAQLTGQRIRSLPLSRYTFS
>A0A5E6QXH6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSVLNINGRDYTVDVDPGTPILWTLRDALGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PITAAEGRRITTIEAATNGSDPVGTAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTAAEIDSAMMGNICRCGTYVRIRAAVADAAKALA
>A0A5E7FQM4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSIKALSRRGFLKGSAWLGGGLVVAFVIPGAHRFASGAENQGMVFAPNAFLRIGNDDSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAADYGLAAFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSQISTESGLVIAGDKRATYGELADDAGKL
PVPDPASIKFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVDWDLGPNTGLDSQAL
LESFRKLATTPGVSASKAGDTDGTLGKAVKTVDVEYSVPYLAHAPMEPLNCTVNITRNKC
EIWTGTQFQTLDQMVAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
GPVKTVWSREDDIRGGYYRSAFLHHARIGLDAAGLPIAWKHVMVGQSIMAGTSLEATTVK
DGIDKTSVEGVADSPYLTGLAHHQVDLHSPKTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVDYRRTLLKDHPRHLGVLNLAVEKAGWKAPLPDGHALGVAVHESFGSYIAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKDGRVEQSNY
HDYQVLRLNEMPLVEVHIVPSSEKPGGVGEAGVPPTAPAVANAVFALTGQRLRELPLDLS
GV
>A4YPZ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MTPATIRLTVNGRTHDVAAASDTTLLHVLRNDFALNGPKYGCGLGECGACTVLIDGRAAR
SCVIPIEGCIGRSVVTLEGLGSRDAPDPVQQAFITEQAAQCGYCLNGMIMTTKALLTMRP
DPSLEEIKQALRYNLCRCGAHVEILRAAMRAAGYTLEALD
>C5ASW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)|TrEMBL
MIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHLGGTAARACIT
PVSAAEGQEITTIEGLSPDGNHPVQVAWRDLNVAQCGYCQTGQIMQAASLLKDSPKPTDQ
QIDENMSGNICRCGTYPRIRAAIHQAAGQAPATKGDRL
>M9RBU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Octadecabacter antarcticus 307|TrEMBL
MGRIKTIARRSFLIGSAAIVGGVAFGVYQVNKDAPNPLVAGDGEATLNPFVLITQDGVTL
IAPRAEMGQGVQTTLAALAAEELDVAWEDITVLHGPPAQAYYNSVFLGFAIPGAHYKDTP
FKHGLRQQVGKIGKLLDLQGTGGSTSMKDFYERMRHAGASGREALKIAAAKQLGVDVAEL
TTQDSAVITPDGTRIPYSDLVEAARDVTPPDVELRDKSTWKYLGKPMPRIDMVGKSTGTA
QYATDIQMDGMKFATVRMSPTRNGMISYDDSIAKDMDGVEAIIDMGDGIAVIATNTWLAI
QAAEAVDITWARAAYPADTAGLRAAIVASLDDEPNSVVRDDGDVNAAIAGTEVTAEYYVP
WLAHTTMEPMTATAHFTGDTLEVWSGNQAPTATRDACAKAVGLDPAQVTLNTTMMGGAFG
RRGESDFSVQAALIAKAMPNTPIRMTWSREEDIRNDFFRPAIVAQFRGVVQDGKAAIVDG
KIAGPSVFHISSLRQQGSIPPGPDRLHVEGAADQPYGIPNFRIAGHLTDMDVPLGFWRSV
GASANGFMLDTFIDEMAHAAGADPLQFRLDLARAEHAPSAAVIEAVGDMSGWTGSTPDGI
GRGVAFTHSFGTPVAEVIEVEDTGNGIKINKCWISADLGVVLDPSIVEAQMTSGVIYGLS
AAMQGEITFSDGIAEQENFYDYDAVRMHTVPEFEVRLLENNPFIGGAGEPSTPPSMPALG
NALFDLTGTRARELPLIKTFDLIL
>A0A7U3ZC91|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica OS117|TrEMBL
MAEVLSTKAVVKEANTAASTQTLSAQTLTINGKSFTLDADPKMPILWALRDILGLTGTKY
GCGAGLCGACTVHLDGQPVRACLTSLGQAQGKRLTTIEGLDNQKLKNAWAEHNVPQCGYC
QAGQLMSAAALVAQHPKPSEEQINSAMSGNLCRCGTYPRIKAALQNYAKQEG
>A0A7W9ARI3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas yantingensis|TrEMBL
MSGVTRRRLLAGGGVGLGLIVAWGLWPRQFPTPAPVRDDEHGFGAWIRISEDGRLIVAVP
VAEHGQGVFTVLAQVVADELGADWRTVGVEPAGIGVANANPLAAAEVFGGVDARLPVVPA
SQAAHGARQMLTGGASSLRQFEVPLREAAAAARTMLVEVAASRWGIDATQCATREGFVVS
GDRKLRFGELAADAAGRTPPKRPVLRSDEDNRLSGTSVTRLDTPAKLDGSANFAGDVRLP
GMLYAAIRQGPLGDTRLIAADRAAADAVPGAVKIVTTDRWIAALATDSFAARRALDAARP
RFETRDPVSDDSIAAALDSALAGEGARVAAAGDLDAALSGRRLFRSHYAVAPSIHASLEL
PAATAQFEDGRLRLWIGTLAPGAVRAAAARTLGIGEDAVSVIPMQLGGSFGAGLDTLVAE
QAAWLAAQAGRPVQLSYSRAEDIARDRFRAPAKAAMTARMERDGRVMAWHARIAAPATGR
ELASRVMAGERIANLSLALPGRGGDAAAVAGAEPPYAIPNWAVDHHVAEVGTASGYLHGG
AHGYTAFFAESFIDELARRAEFDASYFRIRMLGQQPRLANCLNTVASIGGWQGGIAGSGQ
GIAAHAFRGSFIAVLAEASVEGGRVRCARLVAAVDCGRVVHPDIVLQRLEGGLVFGLAQA
LGCATRYKAGVAAARTLTDLRLPMIDDLPDITVELIRSEAEPGGVSDLSVPPVAPAIANA
VAAATGQRLRRLPLDPANP
>A0A7W6LRR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium scionense|TrEMBL
MNAPILSRRRFLSASLVAGGGLLFDLNIPLAGAAEGAPQILTAFVRILPDNRVIIGAKNA
EIGQGAKTMLPMLIAEELDVDWAQVTIEQTHADQKIFGGQTAGGSRTTPREWLPTRKAGA
AARAMLVAAAAQIWGVAPATLKTGSGKVSDPASGKSISYAALAAAAAQQPAPDPATLTLK
DPRDFRIIGQSIGGVDTPAIVAGKPLFGIDFKLPGMLYAVLETCPAFGGTFKSANLDEVK
ALPGVAHVLTIKGDGTPESLFDGVAILSTSWWSANQAREALKVEWDMGAVSGFSTEGYAA
QAAQRLKGKADGDIVRAGDVDAAFAAAAKTVSAEYDYPFLAHGTLEPQNCTALFKDGAIE
IWAPTQNPESGRGLVAKALNLPPDKIRINFTRIGGGFGRRLMNDYMVQAAAIAAQLPGVP
VKLLFSRQQDMQRDFYRPAGWHGFRAALDKTGKLTAFHDHFVTFGKDGKPVRSAEMPATE
IPAGLIDTVLLEQSFLATNMPTGWLRAPGSNALAFVTQAFLDEVAQAAGKDLPTLMLELL
GEPRDLPRGPNAPPFVTGRARGVIEKVVAMSGWADRGQLPKGRGKGFAFYYSHMGYFAEV
LEVALVDGMPKVATVWVAGDVGSQIINPMNALHQAQGSVIEGLGQALAGQKITQVAGAVE
QANFDTHPLQRIPDTPQIIVEFVKTDYPPTGMGEPALPPVIPALVNALHAATGKRIRTLP
IVPEMFA
>A0A7G2JN76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia grimesii|TrEMBL
MITLTVNDQPLTFDGDPHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAEGKKITTIEAIGETPTGKAVQAAWVNLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMSGNVCRCATYVRIRAAIHQAAKALD
>B9B6N8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD1|TrEMBL
MSHSASAPRPLAFRVNGVPHRFDAAAPDTPLLLVLRNDCALNGPKYGCGLGQCGACTVLI
DGQPARACVLPAAAASGRDVTTLEGLGSRDAPHPVQRAFIDEQAAQCGYCLNGMIMCTKA
LLDRNPTPDDAAIREALRFNLCRCGTHLEIVRAVHRAARYVRGDDAA
>A0A840FM41|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax guangxiensis|TrEMBL
MPKLKRRHFVLGTVGAVGALVVGWSATPAASRLVPAEPLPAAPGQVALNGWVKVGSDNTV
TLMMSQSEMGQGTHTGLSMLLAEEMGASLEQIRLETAGPDAIYNNQAAILDALPFRPGDE
GAVKRSTQHVVGKLLRSIPGLSGTGGSSSITDQWMPLREAGASARTMLLGAAAALWQVPV
AECRAEAGRVLHVSGKSATFGELAPKAAQQPLPARVALKKPADFKLIGQPARRVDGAAKL
DGSATFGLDVLPPGLLYASIAMCPTTGGRVASFDATAAQKLLGVRKVMALEPVGATLIGT
GATPGGVAVIADTPYHAMRAVKALAIEWDHGPAASLSSAEMIERLSQTLRTRPGNAQLND
GDVAAAFRSSAKTIEAEYRVPFLAHATMEPMNCTVQFKDGKATVWAPTQAPGFTRNAAAK
ALGIDAAKVELHVTYLGGGFGRRYSTDFVTQAATLARETGGAPVQLFWTREEDMAHDFYR
PAYVARCKAGFDAAGALVAWQTTTAGSSMGAPSFMDTTTDGAWNTAYAFPNARVAHEPVE
SAMPTGVWRSVAHSQNAFFVESFIDECAAAAGKDAVAFRAALLAKDERHLRVLRRVAELS
NWGRPPEPGPDGAKRARGLAIHRSFGSIVAQVAEVSVSADRHVRVHRVVCVIDCGVAVNP
NLIRQQMEGAIVYGLSAALHGEITVEKGQVQQSNFHDYMPLRMNECPAIEVEIAASGEAP
GGVGEPGTPPIAPSVANAVFALTGQRLRSLPLKLA
>A0A7T6X7D2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia pickettii|TrEMBL
MNAKTTKPRSGRRRFLLGALGIGGALVVGWGVMPPRSRVGDPGIFPEHNGEIALNGWIKI
TPEGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLSRVRIESAPVERIYGNVVAMGDSSL
PLHPDSADKTWARALHWIMAKSAREIGLIITGGSSSTADGWQPVREAAATARAALVQAAA
REWNVPAADVSIREGQLIGPGGKQSTFGEMAKSARGISAPSNVTLKPASQFRLIGKPAPR
NDLAAKTDGSARFSIDTRLPGMLYAAVVMCPVFGGKLKTFQSKAALGMPGVRYVVPFEGA
GGGAPGVAVVADHYWQARQALATLEPVWDNGPHAKLDSAGIRQQLVSALDSDKGGFTYRS
MGDGLKAFDRADGATIVEAEYSAPYLAHATMEPINCTAQVTADGVHLWAPTQVATLAQLV
AARAAGVSGDKVQIDIPLIGGGFGRRLESDFISQAVTIATKTEGKPVQVIWSREEDVRHD
FYRPQAIARLKARVESGKVTAIASRSAGQSILAGELDRLFGAPSVGIDRYTAEGLFDLPY
EIEHEHIAHLAVDLPVPVGFWRSVGHSYNGFFMEGFLNEVAAAAKLDPLAMRRNLLKDHP
RELKVLDTAAQAAGWGQPLAPAADGAPRARGIALHPSFGSVVAQVVEVSMKDGKPRVHRV
VCAVDCGTVVNPGIVAQQMESAVIFGLTAALYGRIDIKDGQVVQSNFPDYPALKMVETPV
IETHIVPSTAEPSGMGEVGVPPIAPAVAHAMAQLTGKPVRQLPMV
>A0A095B7W9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter tropicalis|TrEMBL
MPSLFVSKTDNALNPILRRHFLGGGIALAFAGLPAARSKVAFAQTSLNVRPPSDITLGGV
VRIGSDNKMSLIVPNIEMGQGIYTTEAIIIAEELEVDPKDITVLPAFPQDVDVPPFLYPL
KRRVPVFYGLGLVG
>A0A840MYD9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Afipia massiliensis|TrEMBL
MNVHIKDTVTRASALSRRSLLKAGAGLAIGVYIARSGKAFAQGAPAAAQVNIVPNTFLII
KPDNTVTVLCKHIEFGQGPFTGMATLVAEELDADWSQMRADHAPSNPVLYKNLGFGVQGT
GGSSAISNSYEQMRKVGAAAREMLVAAAAKQWNVPASEITVENGVIKHPSGKEGRFGAFA
EKANQLPVPANPKLKDPSQFKLIGKEGAVKRLDSAEKSNGTAVFTLDINEPDMLTVVIAR
PPRFGGTVASFDATAAKAVAGVVDVKQVPTGVAVYAKGFWPAKTARDLLKITWDDSKAEK
RGTAQLLTEFRGLSKTPGKTVKTEGDFDAEVAKPGSRIIESEYVFPYLAHAAMEPLNAFI
HWQGDTASSRFGSQFPTPDHATIARILGLPMEKVQLKTILAGGSFGRRAQQTVHVAAELA
EVAKAIGPGKPIKLVWTREDDMRGGYYRPFSIHRMRGVVRDGKIQAWSDTIVGQSIMKGS
PFEAMTMKDGLDATAYEGSNEIPYDVANFKCDLHQVDVGVPVLWWRSVGHTHTGYAVEAF
VDELLEAAGKDPVEGRLELMSKKPRHAGVLRAVAELADWKNAKLEPGRARGVAVVESFKT
FVAQIVEVSMGDEGPKVHKVWCAVDCGVAVNPDIIRAQMEGGIGFGLGHILYADVPMEDG
RVVPGNFDTYRSLRINEMPAVEVTIVKSSESPTGVGEPGVPPIGPAVANAMAKLGQVRPR
QLPIVPGASA
>A0A3S9LAA9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella khirikhana|TrEMBL
MTSLKINGRLFTLDADPKMPLLWALRDLMGLTGTKYGCGAGLCGACTVHVDGEPMRACLT
SIQSLEGKSVTTIEGLTDDKLKDSWRRHKVPQCGFCQAGQLMSAAALVSRHPAPSDSQID
EAMAGNICRCGTYTRIRAAIKDYQGKQEAKS
>A0A3B0M4F0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibaca ekhonensis|TrEMBL
MSITLTVNETEYRTDAAPDTPLLWVLRDELSLTGTKFGCGIAACGACTVHVDGQAVRSCQ
VRLADIWGPVTTIEGLGDQTPLQAAWERHQVAQCGYCQSGQIMQAADLLANNPSPTDDDI
DAAMGGNLCRCGTYTAIRAAIHDAADQMGGAQ
>A0A3B0MBQ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibaca ekhonensis|TrEMBL
MGRPRTIARRSFLIGSAAILGGVAFGAYFVIRPTPNPLLEGLAQGEAALTPFVKITPNGI
TLIVPRADVGQGIASTQAMLIAEELDIDPATATLDPGQPHQAYFNAAVAAESMPFAGWDH
GFVASTVRDLMGHVARLTSSQFTGGSSSVADLHETLRMAGATARETLKAAAAARAGVPSA
DLRTEDGHVVLPDGTRIPYTDLAAEAAAIKPITDVTLRPASEWTRLGKPYQRLDIVAKST
GTQDYGIDMVLPGMLHATVRANPGRGGAMAGYNADAALAMQGVRSVVKVDEGLAVIADNT
WFAFQAAQALEVSWLPPDYPASSAEMWQALTDARTDEFRNSRLRDDGDVETTLSEATVIE
AEYRAPFLAHAALEPLCATVLVEPDKVEIWTSTQIPAVVRDAAVEITGLDPSQVTVHALP
AGGSFGRRLDHDYVVQAIQIAASMPGTPIKTTWSREEDMTHDYPRPLHMAVGRGAVGNGR
VLAHDLDSISPSLVSSWFGRIFIVPPGPDTMLVWGAFDQPYAIPNYRVTGYAAPPLMPVG
SWRSPGACSNSFFHESFLSELIHAAGADPLEERLRLIADADSRRVLEAVGAMSNWSGADI
GPGRGRGIAFAHTHGVPVAEVIDVTITDRGIRIDEVWIAADCGTVFDPVNAEAQLTGAAI
FGLGHAMNCELTYENHAVQQTNFHAFEGMRLHQTPRFHTQLLGLAERVRGLGEPATAPAA
PALADAIFAATGQRLREMPFSKSVDFA
>A0A7W5Q0E9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK313|TrEMBL
MSDQVFTPTRRSLLKGALVLSFALPLATGRLRAAALAEAAAVGAGDNAAFHPYGLIRIDR
SGITLVIPNVEMGQGIYTAEAMLMAEELEVDLDQIQLEAAPANPKLYATALLHSQGTGGS
TSIRSWWEPLRKAGAGARTMLISAAANQWQVDPASCKAERGAVLHPASSRTIAYTAIAAD
AANLPVPADVPLKDPSTFRIVGKPMKRLDTPAKVNGTAKFGLDIRVPGMKVANVIACPVF
GGTLKAVDSTAALAVPGAIKVLTIDNAVAVVGDNTWAAQKAARLLNITWDEGANVAHSSS
DIHAQLAQSLEQGSPIVALDEGGARDAIEKDNKRIDAIYDLPFLAHATMEPINTIVHVRA
DGCDIWCGTQVPATATAIAAKITGLPPESVNVHNQLLGGGFGRRLEADSIAQAVALAKQV
DFPLQVVWTREEDIRHDYYRPAYHDRISASLGPDGVPTALWHRVTGGSVLAHYAPGALPK
NGLDRDAVEGSTETPYKIEKHLVEYVRQDPPEHFPISWWRGVGPNHNVFVIESFIDELAH
AAKDDPVDYRRKMLADNPRALAMLNLAAEKSGWGQPLPARSGRGISLHQAFGSFCALVLE
VEVSPQGDIRMNKAIAAIDCGYTVNPDTVVAQIEGGTIFGLSAALYSGIEFDRGRTVQSN
FHDYRILRIDEAPKLEVYRAENTEKPGGIGEVGTVSAAPALGNAIFAATGVRLRRLPYDR
MQLMSQGADKHVVGNLAPIGGAGLALLAQTALSRSEAGSERREGEGL
>A0A6M4GVA1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MNVTRRQFLVTSAAAGGGLALGLHVPFSAEAKSAAATEVNLWVAIRPDDTCVIRIARAEM
GQGTLTGLAQLVAEELECDWSKVTTEGVTPGRNLAAKRAWGEMGTGGSRGIRTSHEYVRQ
GGAAARIMLLQAAADEWKVPVSELTVENGVITHAGSKKKTTYGKVAAKAAKLTPPDVKTI
KLKDPKSWKVAGQGLNRLDTRDKLDGSKVYSIDVKLPGMLNAAIKQCPVFGGKLVSYDAV
AIAGMPGVKGAVKVDNATVAVVADTWWHAKKALDALPITWDEGPNAKVNSAGIAAHLKSG
IEAEKAFVGWKEGDAPKTLAASAKRVEAIYGTPFLAHSTMEPMNCTAKVSAEGVDVWVPT
QNAEASLAAAAEAAGVPLEKCEIHRTDLGCGFGRRGGNQDYTKQAVSIAKQFPGVPIKMI
WSREEDTTHDFYRPISQCKLSAGLDEAGNLTALQIRVSGQSINAWVNPNFDPEGKDQRQL
QGIWQAAGDAQFGYTVPNLQVEYAMRNTHVPVGPWRGVNTNQNGVYTECFMDEVAKAAGK
DPLEFRRALMSKHPKHLAVLNAAAEKAGWGTPLPPGVHRGIAQFMGYGSYSAAVAEVSVS
PAGELKVHRMVLALNCGHAVNPAQIAAQVEGSVAYGLSATLYGENTVENGRIVEDNFHTY
PILKLAEMPKVDTVIVPTYDFWGGVGEPTICVVAPAVLNAIHAATGKPVRQLPLKNQKLV
>A0A177G720|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MRFDLKINGVVREVDVPPDMPVLWVLRDILRLTGTKYGCGVAQCGACTVHLDGQPVRACL
LTVAAAAGHDILTIEAIEHTETGAKVQQAWLDEEVIQCGYCQSGQIMAATALLQQIPQPT
DADIDEAMAGNICRCGTYVRIRKAIHKAAAHES
>A0A378YUP2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea pnomenusa|TrEMBL
MRELRFSQYPGVAVGDYTGLSRRGFLKTSALAAGGLMLEMSLPGAMRGAAAQGAAPAPVV
PSAFVRIAPDDTVTIQVNRLDFGQGVQTALPMLVAEELDCDWAKVRSELAPAADVYKDPL
FGIQMTGGSGSVAHSWLQYRRIGASARAMLIAAAAQQWKVPAAQLKTENGVVLGPNGQRA
TYGSLAARAQAMPVPADVPLKSPSAFRLLGKPTGRLDARAKSTGVPMYGMDFKLPNLKVA
VVARPPVFGAKVKRFDAKAAKAVKGVRDVLEIPDDRGGTAVAVIADGYWQAKTGRDALKP
EWDTSGVEHVDTTAQLAKYKEMARTPGTVAIDADVSKLKGAPKTLVAEYSFPYLAHAPME
PLNCTVQLSDKGAEVWTGTQFQTVDQAAIARTLELKPEQVKLHTLMAGGGFGRRAVPTSD
YGVEAAQVAKAWRKAGHREPVKVIWSREDDIHGGYYRPMYVHRAEIGLDDKGNILAWNHT
IVGQSILAGTPFEKMMVKNGIDGTSVEGVSGTPYAVPLRLTLHSPKVNVPVLWWRSVGNT
HTAYVMETLIDELAKQAGQDPVAYRYALMGDKHPRHKEALALAVERSGYGKTRLPEGQAW
GVAVHESFDSVVAYVVVAEMRNGTPRLVSATAGVHCNFAVNPLTVAAQVEGAALMGLGTT
LPGAAITMKDGEVEQSNFHQYMVARLPDMPAISVHIASSGDAPTGMGEPGLPALAPAYAN
ALFTLTGKRLRSLPFDVAKA
>A0A346BB08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinilytica|TrEMBL
MGSLNINGRAVAVQAEPDMPLLWVLRCDLGMTGTKFGCGVGICGACTIHLDGKAGLACQT
PMSSLHSQKITTIEGVQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKQKPNPTDA
DIDAAMSNIVCRCGTYPRVRAAIHQAAAKRRPA
>A0A095VZR1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia gladioli|TrEMBL
MTTLNINGVSHTVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGEAVRSCVL
PVAAVAGRNITTIEAVGMTPAGAKVQAAWRKIDVVQCGYCQSGQVMAAASLLASNPHPND
ADIDAAMAGNICRCGTYNRIRAAIKLAAQEA
>A0A5S9NV07|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania aliphaticivorans|TrEMBL
MTNFTSISRRDFIRVSVLAGGGLLVACGGGSGSSNGGTPDNPTDNNGSPTTPAETYGVGE
FMRISTDNKITILVGAAEIGQGSLTAIPMIVAEELDADWSQVSAELSPVAANFNNPYFQN
LLQFTVASSSIRGYFDAQRTVGAAVRQMLVNAAAKRWAVAASSLRTESGYVIDDTNGRTA
SYGELSSAAAEESVPVNPSLKDPASYTLIGTSTQRLDAANKTDGSFQYGIDVDIPNMLTA
VIARPPRFNGQALNVDDNAALAIPGVHSVHTILGGVAVIADDFWAADKGRKALNVEWNEL
LAGRTDSDIQRSTYDLRLNLPGVPIRSDGLVLLAQTLASETISADYYFPFMAHAAMEPLN
VVVDYDGSSAEIWTGTQSATLDKVFAGLTLGLLPNQITFHTMPSGGGFGRRGNPLADYVR
DACAVAKELRQPVKVMWTREDDMKGGFYRPAASVRVSASIDSDNNISAWTHRAVTQDVTA
LLYSENLLDNLADFTLPPLKELTDFETGMPYDIDNVLMDAHLTVNLSMPALWMRSVNKFS
DVFAQETFVDELALKVGKNPYNFRYDLLSEKPRHRAVLEAAANAASWGFSPSGTSQGIAV
MGHWNSFVAQVVDISVSADREITVHKVVSAVDCGTAINPDLVKAQVESAVVFALSSIFFG
EILLEDGVVQQSNFDDYPVLRMYQTPVIETIIIDSQNPVGGVGELGVPCVGPALANAIFN
AIGERIRELPLTRSNFKIA
>A0A0D6I7G5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MTTTMQVSRRGFLKGGLGALTLAVTGNGLVSAVWAADEPKKYGADSMPGGTVDDPLAFVS
IAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEAAWDRVRVVQADADEARYGNQNVDGSR
SVRHFLMPMRRVGAAARQMLEAAAAARWSVPLAEVRATQHEVVHAPSGRRLGYGELAADA
AKLPVPAGDAVKLKTRAEFRYIGKDEVRLVDLEAIGKGEAMYGMDMRLPGMVYAVVARPP
VVGGKLRRVDSAKALAVPGVLKVVEIPAMAGAPAFQPLGGVAVVASNTWAAMQGRAALAI
EWDDGPNAAYDSVAYRETLTEASRKPGKVVRDQGDAPQAWAKAGETERFMAEYHVPHLAH
ASMETPVATVRIQDGAAEVWTSVQNPAAAQEAVAKRLKLKPENVKVHVLLLGGGFGRKSK
PDYVDEAAIVAQAMPAGTPVKLVWTREDDIHHDYLHTVSAEHLEAVVGKDGKVQSWLHRS
AAPTIASLFTEGAKGEQLFESAMSAINMPYVIPNVRVETAEVAAHARIGWFRSVANIPHA
FAAQCFIAELAHRAGRDHKQYALDLIGPARRIDPGTLADTWNYSESPERYPYDTGRLRGV
IEAAASGAKWGRELPKGHGLGLAFCYSFMSYTATVVEVAVDEKGEVRVVAVDMALDCGPQ
IKPERIRAQMEGGAIMGLSLALLGEITFEKGRVKQNNFYDYEVLRHNASPRVIRTHLVND
DHALPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRSVA
>A0A484Y0H6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MVWVVTPGCARTQERSDWTSRALSDRIELRSDGTVHLHIGRIEMGQGLYAGVMQLAAEEL
DLPMARFRVAPVDTASAPDENFTDASASMRRTGMAVRRAAATARAVMLALAARQWRIGAA
SLRVENGIVRSAAGHRTDYWRLLAEANGKALPAARGSLKAPEAYRLLGRSVPRPDLPAKV
TGAAVFVQDLRLPGMLHARVLRPPSLAASLEASDTQAAATMPGVVRVLRNGSFLAVVAQR
EEQAIAALEVLRAGCRWHEPATLPDPAGLYAYLRSEAGLPEIVPSSGDRRLTATYEVPYR
MHASIGPSCAVAQFEDGRLTVWTHAQGVYPLRASLASLLDLPRRAVRCIHLEGAGCYGHN
GADDAAADAALIAQAVQGAAVRLQWSREDEHGWEPYGPAMVMRLSGTLDAQGRISAWHHA
VASPTHSSRPGGAARLLAARHVEPAIAPSFLHGLTTWAGGGRYNARPYYRVLASVESHLV
RRAPLRSSALRSLGAYANVFAIESFMDELAEQAGADPLQFRLAHLDDTRAADVLRLAALR
FGWEQGRAQSHGIGFARLNGYGAYIAVCAHATVESDGRARITRIVAAADCGELINPDAVR
NQIEGGIVQAVSWTLYEQVRFDRTRITNTDWSSYPILRITEAPGVEVHLIDRPGADYLGL
GEAAQGPAGAAVANAVARLRGHRHRTLPLHVGGAG
>A0A177IU07|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MLTLNLNGVAREVDADPDMPLLWVIRDRLDMTGTKYGCGIAQCGACTVHMDGQPVRSCQT
RIGDVGEAKITTIEGVEGKVADAVKAAWRGLDVVQCGYCQSGQIMSAIGLLTENPKPSDA
DIDGAMDGNVCRCGTYQRIRAAIHEAARSLA
>O30328|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Komagataeibacter europaeus|TrEMBL
MTTFRLNGREVTVDVPGDTPLLWVIRDEVGLTGTKFGCGIGMCGACTIHIGGRATRSCVT
PVSAAEGADITTIEGIDPEGNHPVQQAWREIQVPQCGYCQSGQIMQAVSLLKDYPSPTDE
EIDAVMAGSLCRCMTYIRIREAIKKAAATARGDASNG
>A0A291FY61|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter piscinae|TrEMBL
MASLKKIARRSFLIGSAAIVGGVAFGTYKYHQPAPNPLEQEDGRAVLNPFVFVDQSGVTL
IAPRAEMGQGVKSAWASLIAEELDVDPAKVTVLHGPAAKAYYNSAMMSEALPGRGYDASD
FQHSLGEIVGHMSKFLDLQVTGGSSSMRDGFERMRHAGASARETLKQAAADQLGVSRDQL
TTEDGHVIDPDGARLPYSALADAAASLAPIEADLRPASEWRLIGKDVPRIDMVAKSTGTA
EFGVDVRLPGMKFAAIRQSPHFGVGKTAFDASAAEGMAGVERILDLGDAVAVVASNTWLA
QQAVDAIDVTWEKAPYPETTEAIFDEIARSFDAAPNSTMRDDGDVDALPEGATVIEAEYR
LPYLAHATMEPMNATALYSGDSLQIWAPNQGPTIVQKNAAALAGLDTDAVEVNTTYLGGG
FGRRIETDYTDRAVQIALQMPDTPVQLTWSREEDMAHDVYRPGAVARYRAAVKDGKAVMV
HGKIAAQSATVEGAGRMLGLPMSGPDKGHVDAAFNQPLAIPNFRVEGYLATPMLPVGFWR
SVGASFNGFFSDSIIDEMAHAAGRDPLEFRLELARAEWDPAAKVLETVRDMSGWTGRTPD
GIGRGVAMAYSFGTPVAQVIEVADEEGQIRMTNAWIAADLGRVIDPKNTRAQMFGGMVYG
LSAACFGEITIDRGAVEQENFPDYDALRMHTMPRVEVTLLENQPRMGGAGEPGTPPAAPA
LANALFDLTGKRARQLPLMHEFDLLV
>A0A0P1F8D3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassobius gelatinovorus|TrEMBL
MKLVVNGTAHEIDVETDMPLLWVLRDELGLTGTKYGCGVAACGACTVHIDGVAVRSCQTP
VGDVDGPVTTIEGLGNPAALHAVQAAWDEHQVAQCGYCQSGQIMQAADLLANTPNPTDSD
IDDAMSGNLCRCGTYPRIRAAVKTAAAKLQEA
>G4STD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MTTLMINGKQYELDAEDDMPLLWAIRDIAGLTGTKFGCGIGMCGACSIHLDGELVRSCMM
PFGAAKDKAITTIEGLASEEGLHPLQQAWIDKDVSQCGYCQPGQIMAAAALLRENPNPSE
DEIRTKMTNYCRCGTYLQIFEAVKQAAQLQGEQS
>A0A653XPB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides sp. AX2bis|TrEMBL
MPKQTFILNGKSVTVNVADDVRVLWVLRDILKVTGPKYGCGINVCKACTSHVNGKAFNPC
AVRVGDLKSTDKVTTIEGLATLDGRKDLHPMQQAWIDRDVAQCGYCQPGQIMEAVALARR
VRREGRSITEADLDAIRNVCRCGTYTRIREAVVQGARAMGPND
>A0A377RWP3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MAAHSSPSRRRFLLGGLGLGVAGVGALVLGWGVLPPRQRLHGSAPLPLQDGAVALNGWLA
IGTDGTVTLAMPRSEMGQGVHTALPMLVAEELDVPLASVKLIQAPNDKIFGNVAMLKDSL
PFHPDDQGRLKALAQWTVAKAARELGVIVTGGSSSVKDGWGPMREAGASARAMLVGAAAA
LWQVPAAQCRTQDGEVLHPDGRRASYASLAQRAAAIDPGTPVLKLPRDFKLIGQPAPRRD
TPSKVNGSARFGIDARPPGMLYAALHLPPRLGDTLSAFDAAPIVAMPGVKKVLDLTPQLA
QRSVSCAAVVADTWWRAKQAAAALPTQWKAGPQANLSSADVYAEFARLLDTEAGYAYHAS
GEVESKAVQGMRQVSAEYRAPFLAHATMEPVNCTAQVKNGKVMLWASTQAPGIAVDVAAK
VAGVDAKDVSIEVLLLGGGFGRRLEVDMVAQAVAIALQCDGAPVQLVWTREQDTKHDMYR
PAALARFAARLDEHGRIASWDNKSVSGSITHQYLQRNFGLPGAGPDKTTAEGEFDMPYEI
ANQRIAHVIADSAVPVGYWRSVGHSHNAFFKESFIDELAHAAGQDGIAFRRAMLVRHPRH
LAVLDAAVAKAGSPPPGHAHGVALHQSFGSIVAQVAQVSVENGEIRVQRVVCAIDCGIAV
NPNIIAQQMESAVLFGLSAALGGEITFKEGRVEQGNFHDYPVLRMGQTPEVETVIIASAE
HPEGVGEPGTPPIAPAVANAVFSLTGKRLRSLPLRLA
>W6VTL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. GM30|TrEMBL
MIAFTVNGERRELDEASPSMPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPLAAVAGHSITTIEGLSPNESHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVSD
DSIRNAMSGNICRCGTYGRINKAIKRAANAPKEA
>A0A0K3BH37|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kibdelosporangium sp. MJ126-NF4|TrEMBL
MPSYTFVVNGTSVTVDAPADMPLLWVLRDKLGIHGPKYGCGINVCKACTSHIDGKAVNPC
VVPVAEAAGRTVTTIEGLADGDELHPVQQAWLDNDVAQCGYCQPGQIMAAVALLNAKPNP
TDADIDAIDNVCRCGTYARIRQAIKAAAVTTRKSSR
>A0A0D6JF20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Filomicrobium marinum|TrEMBL
MAITFNVNGEPREVDVDPNTPLLWVLRDELGLTGTKFGCGVAQCGACTVFVDGMPQRSCV
TPVELINGSDITTIEGVEGPEASAIQKAWVEIDVPQCGYCQSGQIMSAVALLRDISDPTD
EDIDGAMTGNICRCATYVRIRQAIKNAAAELKG
>A0A839PMC8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. RMAD-H1|TrEMBL
MPIRTVALHSRALSRRSFLIMAGSFGVAVALGGLPREASGAAVASAASGNYRPNAWVTIA
ADGTVTIMSPASEMGQGIMTTLPLLIAEEMDADWDRIRIVQAPSDAATYGNPGFYGIQLT
GGSESTRGYYDLLRLTGAQTRKIILASAAGILDVPVSELATEPGRVLHGPSGRSLGYGEV
AAVGELPDPLPQATEADLKSRDRWRYIGRRDIPRVDVPSKVDGTATYGIDVQLPGLLYGA
VLRAPVQGERPETIDDAQARAVPGVAHIVPLPYGVGIIGETVEATHRAKDLLHVTWSTSS
RVRNYTSGQLLEHYRDVARDLSQPGVNAFSEGDAETAIAAAATVIEADYMSDLVYHATME
PMNATARVTGDTVEIWAPTQGPTGTQRFAAEVAGTTPEKVKVNTMLLGGGFGRKAEADFI
VDAVSLAKEVEGRPVKVIWSREDDVRHDKFRPLEAQHIQVGLDAQGNIVGWRHRIVADSI
FARTMPDLFASQGGHDDVVTEGAHFNYAVPAHRIDYIRQDNGLDIGFWFAVGVGYTRFGI
ECVIDEIAASRGTDPLQLRLELLKDQPRARNVIETVAGMADWSRPRDGRALGVAYSDAFG
SHCAQIAEISLDRQTGAIRVHKVWCAVDPGVAIQPRHIEGMMIVGITNGTSHALFEQINI
VDGEVQEGNFDTYRVIRMSEAPEIEVAVVPTSGSPVGGMGQVGLPPVGPAIANAVARLTG
GVRLRHYPFLPERVLAALNA
>F8GX56|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MFFATAQFLLLGCGHTASPDPIEKHRPPNSKDAKMNLNVNGRDYAFDVEPEMPLLWALRD
ELRITGPKYGCGVGYCGACTVHMNGTPVRSCSMPVGAVSGPVVTIEGLGQPDALHAVQRA
WIEHQVAQCGYCQAGQMMTAAAFLAATPAPTDKQIDDAMSANLCRCGTYPRIREATKTAA
KLLKGV
>A1K1D4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azoarcus sp. (strain BH72)|TrEMBL
MTRFTLNGKPVETALPDDTPLLWVLRDGLDQTGTKFGCGMGLCGACTVHLDGQPIRSCST
PLSAAAGKKITTIEGVGKARVGAAVQKAWQKLDVVQCGYCQSGQIMSATALLTANPKPTD
ADIDAAMGGNICRCATYVRIRAAIHEAAKSLA
>A0A7W9BRW0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas prati|TrEMBL
MTRFTVNGQPIRYLLDPETPLLWALRDASNLTGTKYGCGAGLCGACTVHVDGNAVRSCQV
AIGTLEGSFVTTIEALSRDRGHPVQQAWIAEAVPQCGYCQSGMIMAAAALLSRNGNPSDA
DIDAAITNICRCGTYPRIRRAIRAAAAVAAGRLTLEGGPAPGIDPADAARAVPAMTVARP
PE
>A0A2R8B4I3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Defluviimonas aquaemixtae|TrEMBL
MRTININGTDHQLDVDDDMPLIWAIRDIVGLTGTKFGCGQALCGACTVHLDGVPVRSCQT
FVGDAEGAAITTIEGLSGNVPETVQTVWAEMDVPQCGYCQSGQIMSAVALLAETPKPSDD
DIDAAMGGNLCRCASYHRIRGAIHEAARRLEA
>A0A7W5ZUR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium hassiacum|TrEMBL
MSVSLTVNGRKRVVDSDADKPLLWVLREDLDMPGTKFGCGAGLCGACTVHLDGEAVRSCQ
TPISDAAGKAITTIEGVAASAIGKRVTDAWVALDVPQCGYCQAGQIMSATALLKQNAKPS
AEDIDGWMSGNICRCSTYLRIRAAIRQAAGLPAEVALFDAADGEQVA
>A0A2N9L4N8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfotelmatomonas gaucii|TrEMBL
MPLKLNVNHEVRTVDVPPDTPLLWVLRDLLDLPGTKYGCGIGVCGACTVLVGGKAVRSCM
THVGNVAGEPITTIEGLSMDATHPLQQAWEALDVPQCGYCQPGQIMTAAALLSQTPHPTD
ADIDTAMSGNLCRCGTYPRIRQAIHHAAESAHAPTLKG
>A0A8I2C2B8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MNIRTNIPTDSGKLRGFEKHVKVENVSRRSILKGLGIAGSFVLAAPVMTRQAFAYETGAG
KMPHGVVVDPRVFVAIAPDGIVTILAHRSEMGTGVRTSLPLIVAEEMEADWSRVHVQQAH
GDEVKFGNQDTDGSRSTRHYLIPMRQIGASARSMLEAAAAKKWGVPVTEVKAQNHEVVHS
ASGRKAGFGELAADAAKESVPSVEGLKLKDPKDFRYLGKGQVSIVDLHDITTGKAPYGAD
VRLPGLKYAVIARPPVTGGKLKSFDDSAAKKVPGVEKVMEVKGWPWPSKFQPLGGVAVIA
RNTGAAIKGRDALKIVWDDGANAKYDSVTYRASLEEAARKPGLVVRKEGDADAALKSADK
VITGEYYLPHLAHVSMEPPVAVADVKGDKATIWAPVQSPGGTREDVAKTLGIPEDNVTVN
VTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDVHHDFLHTVSVERIEAGLDK
SGKVIAWRHRSVAPTIASTFAAGANHEAPFELGMGLIDNPFEIANLQCENPEAAAFTRIG
WFRSVSNIPRAFAVQSMVGEIAHATGRDQKEMLLELIGSPRIVNLSSVKDPWNYGEPYDS
YPIDTARLRKVVELVADKGEWGRKVPKGHGLGIAVHRSFVSYIATIVEVAVDDKGKFSVP
RVDTAIDCGTYVNPERIHSQIEGAAIMGLSLAKYGEISFKDGKVQQGNFDDFPVIRMDES
PVITNVHIVPPGADTPPSGVGEPGVPPFAPALINAIFAATGKRIRALPIGKQLET
>W6K543|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Magnetospira sp. (strain QH-2)|TrEMBL
MTVEVSRRGFLQGAATGAAALVIGLNARGVLAAGTESMALNPFVRIDEQGVVTVILKHFE
MGQGTTTGLTTLIAEELDADWATVRTEFAPADNDKYKNLFFGTQGTGGSTAMANSFKQYR
EAGATARQLLVSAAAETWDLDESEITISDGILSAGPHAGHFGQFIRVASTLTPFPEVTLK
SPDQFKLIGNATLPRKDSRDKTDGTAVFAMDVKIPGMVYVAIRRSPKFGGVVTTFDATDA
AQVPGFIDAKILANKAGVAVYARNTWAAFQARDALSAEWDFAKAERRSSDEMETTIRRQT
GRPQFQVMKEFSTEQAAISVDGAAKTIEAEFYFPFLAHAPMEPVNCVVEPTETGGVRLHD
GCQFPGGVQPAVAKVLNLIPEQVEIHTVYAGGSFGRRANPVSDYPVEAALAFDAMGRKVP
VKLVWSREDDLHGGFYRPLAVHKARIGLNAQGALVGWDHRVAAKSILKGTPFEAFGVKDG
IEHSMVEGIDDSLYGIPNMGVGVSDFITPIPALWWRSVGHTHTAYAMESLMDMIAHETGR
DPVALRLSLLDKGDAKQARLAGVIEAVRDASGWQPGQKRGFAAHFSFGSYVAMVADVTVN
GTEVHVDHLHMAVDCGVAVNPDVIKAQMEGGAGFGLGAILRNEITLDEGLVDQQNFPDYE
PLRMADMPDISVTIIQSAEPPTGVGEPAVPPTGPAVANGIFALTGKRITDLPMTKAGFEF
V
>A0A1V0PXC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MKKLTVNGRDLAVDVEDDTPLLWVLRDTLGLTGTKFGCGISACGSCTVHVDGVAIRSCSV
PVADVEGADIRTIEGLSDGTALHPVQQAWVELDVPQCGYCQSGQIMAAAALLARTPEPTD
ADIDATMINLCRCGTYQRIRDGVKRAAEIMKA
>A0A2U3KRX2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MSSIRLAINGRSYTVDADPQTSLLNVLREHLDLTGSKYGCGEGLCGACTVLVEGKAQRSC
ITRVGAVGEKQITTIEGLASGERLHAVQEAFLEAGAMQCGYCTSGMIMSAVALLGKNSQP
SRSDIIDFMDGNVCRCGTHPRIVAAIEKAAKVMAGSAAAKGVGR
>A0A2N9CXA1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MRDDHATDAPSTDDTPRRRFLKQTSALLAAGIAIGFRMPDAAAAGKRASGDPHPSAGEFE
PNAWVRVLPDDTIKLVVHKHDSGTGTRTALAAVVAEELDVDPFRVDVITPEDPFFADYIH
PLWKVFSTGGSTSVAMEYERLRRAGATARAMLVAAAARQWSVPASTCTTADGAVLHAASG
RRATYGSLAQAAAQLPAPTQVALKDPAQFRYIGKLRSKRGAAQKADGSFPYSIDVSLPGM
RVAVVTRAPVIDGRVRSVDAKAALAIPGVREVLQIPPRPDVLGGNQAGVAVLADDYWSAH
KGQAALTIEWEDSLFETFDSGTLAARQAAWIDDPTARVVPTIADGDPAHAKAPGARTIEA
SYSMPHKAANPLEPINLTVWAHDGGIEYWGGLQVPSTAMEAADVIGGIPAHRVTLHELVS
GGSFGAREAKYWLFEATWLAVKTGKPVKLMNSREDEMRALFYHAASHHRARAVLDAQGNL
ASLWLRGVMPASPQQWEPGYLERTDRMDFSTTEALTKWEFAYRAPHRDIGWIRMETGVPT
GWFRAVSYIPNVFAVESVMDEAAHAAKRDPVEFRLAHMHDRPRHAAVLREAARCAGWGQP
LPDGVALGVATNQAYDSYVAVVARVVRQDGAVKVEKLTCVADCGIAVSPSGVDEQLYGGL
MWGLGHATADRIDFKHGRVQQSNFDTYRVMRMRDMPDTDIHVVQGDPAKPGGVGELSSPA
VTPAIANAVFRLTGTRLRETPFDLSALT
>A0A2N9CV88|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MITLNINGENRSVDAPDDMPLLWVLRDVVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRKITTIEAVGATPAGHKVQQAWRELDVVQCGYCQSGQVMAATALIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAVKQAAKEV
>A0A0P7XCD8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter sp. HL-58|TrEMBL
MAVSLSVNGVTHTVDVENDTPLLWVVRDELGLKGTRFGCGMGLCGACTVHLDGQPVRSCS
TPVEMADGGNITTIEGLAADGDLHPLQKAWIEHGVPQCGYCQSGQIMSAAHLLQHNPSPS
REDIVAAVSGNLCRCGTYSRIVAAVEAVVDSRREQSGREEA
>A0A0N7LZM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter multivorans|TrEMBL
MKLTVNGTPHEVSVEEDMPLLWVLRDELGVTGVKYGCGVAQCGACTVTLNGEAVRSCQVP
AADLEGAEVTTIEGLGTPDNLHIVQQAWEKHQVAQCGYCQSGQIMQAAAFLSQNPNPTDA
DIDDAMSGNLCRCGTYPRIREAVKDAASMLQGA
>A0A5E7YXT9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Imperialibacter sp. EC-SDR9|TrEMBL
MAIFKLTINGQQKQVDVDPATPMLWVLRDNLDLVGTKFGCGIAQCGACTIHVNGNATRSC
QLPVSAVGDNKITTIEGLSENGDHPVQQAWLQHDVPQCGYCQAGQIMTASALLASNPKPT
DEEIESAMNGNICRCGTYVRIKAAVKTASTL
>A0A1X6YGS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria meonggei|TrEMBL
MASVGKILRRTFLIGSAAVVGGVAFGAYYVSRPAPNPLKPGEGEAALNPFVLIDQNGVTL
FAPRAEMGQGVKTTWAALIAEELDVDLDQVTVLHGPAAAAYYNSAMMGESLPNKGYDISN
FQHNLAEALGVVGRVLSLQVTGGSTSMKDGFERMRLAGASARETLKQAAANRLDVDPSAL
KTASGFVIAPDGDKIAYTELAIEAAAIEAAEAPLRDPSKWRYLGRTQPRLDMAGKVTGTA
EFGVDVRLPGMKFAAVRMNPKLGGVMNGYDDSAAKTMPGVEKVVNLGTGVAVVANNTWLA
NQAVEAIDVDWGDAPYPSETDEIFSHIAKAFDDAPNSTMRDDGDVTTLPDGASEITAEYK
VPYLAHATMEPMNATALFTGNALELWCGNQAPTLIQMRVANVANLDTEAVQIHTTYLGGG
FGRRGEFDFGEIATKVAMAMPNVPVQTTWSREEDMRHDFYRPGAMARMRGAVKDGQAVLI
DGQVAAQSCAQQAVNRYTGLPAAGADKVLVEGFFNQPYAVPNYRMSGHVVDLDIPVGFWR
SVGNSHNGFFHETFMDELALAADRDPLDFRLELAKSEHAPSAGCLEAVREMSNWTGQTAK
GVGRGVALAYSFGTPVAQVIEVVDEDGTIRINKAWIACDMGLALDPDNVKAQMFGGMMYG
LSAACFGEITFSEGEVEQFNFPDYDALRMHTAPQVEVRVLETNRHMGGAGEPGTPPSMPA
LGNALFDLTGERARTLPLINQFNLLI
>A0A149VQQ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ferrovum sp. PN-J185|TrEMBL
MTTELKLNGKLFQLETDPNTPLLWVIRDVVGLTGTKFSCGAGLCGACTIHINGVATRSCI
TPLSDAVGKEVTTIEGLSVEGDHPLQLAWQELNVSQCGYCQSGQIMNAAGLLKQNPHPSV
EEIDQAMSGNICRCGTYNRIRAAIQQAAKKG
>A0A7W8E4Q1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Granulicella aggregans|TrEMBL
MVTLTINGVVQEVNVPSNEIPMLWVLRDIVGLTGTKYGCGIEVCGACTILVDGSPRKSCQ
MSVNEGVGRSITTVEGLSPDGVSHPLQKAWVQLQVPQCGYCQSGMLMSACAHYNSGSNGD
GIEIDNLCVCGTYQRVKQAIQLAATL
>A0A238KZS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria arenilitoris|TrEMBL
MASIGKILRRTFLIGSAAIVGGVAFGVYYVNRPAKNPLKPGEGEAALNPFILIDQNGVTL
FAPRAEMGQGVKTTWAALIAEELDVDLDQVTVLHGPAAAAYYNSALIGESLPNKGYDVSN
FQHNLGEALGVIGKALSLQVTGGSTSMKDGFERMRAAGASARETLKQAAAERLSIDRGQL
KTASGHVIAPDDSKIAYTDLAADVAQMEPIDAELRDPSEWRYLGRTLPRLDMVEKATGTA
QFGVDVRLPGMKFASVRMNPKLGGQMNGFDDSAAKAMPGVEEIVDLGNGVAVIATNTWLA
NQAVEAIEVDWGEAPYPPETDAIFAEIAKAFDTDPNSTMRDDGDVSTVPEGATVIEAEYT
APYLAHATMEPMNATALFTGDALELWCGNQAPTLIQFRVANTAGLDTEAVQIHTTYLGGG
FGRRGELDFGEIATKVAMAVPGTPVQTTWSREEDMRHDYYRPGAMARMRGAVQDGKAVLI
DGAVAAQSCTQQAVERYTGMPGAGPDKVLVEGFFNQPYAVPNYRMSGHIAELKIPVGFWR
SVGNSHNGFFHETFIDEMAHAAGRDPLEFRLELMRDEHAPSAGCLEAVRDMSGWTGKTPD
GVGRGVAFTYSFGTPVAQVIEVVDEDGTIRISKAWIACDIGLALDPENVKAQMFGGMMYG
LSAACYGEITFADGEVEQYNFPDYDALRMHTAPQVEVQVLETNRFMGGAGEPGTPPSMPA
LGNALFDLTGQRARTLPLNKQFNLLV
>A0A6J4UYZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thermomicrobiales bacterium|TrEMBL
MPTTLNINGTDQTVDVDENTPLLWALRNDLGMTGTKFGCGLSQCGACTVHVDGVAARSCI
TPVSAAAGKQITTVEGLSDSGTLSNLQQAWIEVQAPQCGYCQSGQLMAASALLAANPDPS
DDEIVEAMSGNLCRCGTYNRIFQAIKLAASRG
>A0A7Z7RPV5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chromobacterium vaccinii|TrEMBL
MTTTGVSRRSFLKMSGAVGGALCLGFVLSEGGRRAEAAEAKNAIPSPNAFVRIEKDGGVT
IVSNKSEMGQGIYTSLAMLIAEELECDWNRIKVVSAPAAPIYVHTAFHIQITGGSTSTLS
SYDQYRKIGAAARDMLILAAAQRWRVPVSQCRAENSRVFNNANGASLGYGELTEAAGKLP
VPDAVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPK
GFNADAARAVPGVKDVFAISNGVAVLADGFWPAKKARDLLEVEWDRGANAELDSARQRAD
YRARAAKPGQIYRSEGDAKAALAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCEIW
SGTQSQTIDAGMAAAMSGLKPEQVTLHTTLLGGGFGRRAVPVGSDWLKEAMEVAKHHGQD
VPVRLMWTRDDDLAGAYYRPMWLDRVRGGIGADGKPAAWLQTGVGQSIIAGTPFAPMMIK
NGIDAVSVEGTDDMSYALPAVSLDLHTPEIPLPVLWWRSVGHSHSAFSKESFIDELARLA
RQDPVAYRLALMDKAPREQAVLREAARMAGWGRKLPKGHGLGAAVHTSFGSHIAQVVEVS
VKGKELKVVHVWCAVDCGVVVNPDQVAAQMEGGIMFGLSAALFGEITFKDGEVEQKNFDG
YPIVRMFQAPKVDVFIVASEEAPGGTGEPAVPVVAPALANAIHAASGQRRRELPLSRHGY
QMV
>A0A238H217|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia singularis|TrEMBL
MSSDELAVQNESRRALLLGFASGGLLLAIGGPALVQAATANAPGGPPVSANPQYGGAGMP
NGLRDDPRLFVRVAPDGAVTVTCIRSEMGQGVRTSVALVIADELGADWARVKVEQAVGDE
VRYGNQNTDGSRSLRQSFTALRRAAAAARTMLESAAASMWSIDVKQVKAGVHEVVDTKTG
RKLGFGELASRAAELAVPDPATVALKLPAEFRYIGKGKTGLIDGRDIVGGTARYGIDTRI
DGMLYAVIARPPVYGGTVASFDASAARRMPGVIDVIQLNATPLPSGFQPLGGIAVVARDT
WTAIKAREQLRIEWTHGPNAGYDSAAYRDRLEAAAKQPGSVIRNQGDSAAAFAGAAKKIS
AAYYLPHLAHATMEPPAAVAHVHDGQCDIWACTQAPQSARDEVAKALGLPQSNVTVNVTL
LGGGFGRKSKPDYVVEAALLSKATGKPIKLTFTREDDITNDYFHAVALEYFEGALDSSGK
VVGWLHRSAAPSIQSTFKPGIVHEQPGELVQGVVDLPFAIPNIRIENPEAPAHTRIGWFR
SVYNIPHAFGIQSFAAELAHAAGRDPKDFLLELIGPARTFEPNVSVKNTNYGEDPALYPV
DTGRLRRVIEVVAHEAGWGRKLPKGSGLGVAAHRSFVSYTAVICEVKIDQDGKLSVPRVD
IAIDCGPQVNPERVRSQLEGAVVMGLGLALHGEISFKNGRTEQTNFNGYQVLRMNETPRE
IRVHLVEPDNYATPMGGVGEPGLPPVAPALTNAIFAATGRRIRRLPIADQLARADAG
>G8Q265|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas ogarae (strain DSM 112162 / CECT 30235 / F113)|TrEMBL
MSRLSDDFVLSNLSRRGFLKGASATGVLVLAATWGLPEAFAEEKKFGAEGMPHGAVDDPK
VYVSIAADGSVTVICNRSEMGQGVRTSLSMVVADELEADWARVKVQQAPADEARFGNQDT
DGSRSMRHWYEPMRRCGAAARTMLELAAAAQWKVPVSECHAQLHKVLHQPSGRELGYGEL
AAAASALPVPGRDSLRLKQPSEFRYIGKEASRAIDGADIVNGRAVFGADVHFDGMLYAVI
ARPPVYGGKVKSVDSSAALKVPGVVKVVQIEGRPLPSEFQPLGGVAVVAKNTWAAIKGRE
ALKIQWDDGPNAGYDSIVYRKELEAAALKPGKVVRSSGDLDDALAKADSTLEASYYLPHL
SQSPMEPMVAVARFKDGQCEAWAPSQAPQVTRERVAERLGIPFEKVTVNITLLGGGFGRK
SKPDFVVEAAVLAKEFPGQAVRVQWTREDDIHHSYFHTVSAEYLKAGLNQDGMPSGWLHR
TVAPSITALFAPGMTHEAPFEIGMGVTNMAYAIPNLRLENPEAVAHARVGWYRSVSNIPH
GFAIQSFIDELAHKAGQDPLKYQVRLLGPDRKIDPRTLSEEWNYGESPERYPIDTARIRT
VLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTVIVHKADIAVDCGP
QINPERIRSQFEGACVMGLGNAMVGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHLVT
PPGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRSLPVRYQLQGWQQAKA
>A0A238GZJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia singularis|TrEMBL
MSRGLIEAGHADAVSAAGEGVSRRTFLKFGITLGAAAGGGLLLGFSMPAAGGDARRSVIG
GDAAEPAQPGVFAPNAFVQIDRAGKITLVMPKVEMGQGVYTSLPMLIAEELEAPLSSVTL
DHAPPNEKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGATARTLLVAAAAQQWKVDPASCR
AQDGEVLHPASGRRASYGQLADGAAKLPVPKDVVLKKSEDFKLIGKPFKRLDSPEKVDGS
AQFGLDVRLPGMLYAVIVNSPVFGGTVAHVDDGAARKVPGVRQIVIADNAVAVVADHTWA
AKRGAAALNVQWNEGAGARVSMQDIVADLARAAGGNGAVARKEGDVERAFKDAKTRVEAV
YEQPFLAHATMEPVNCTVHVRPDGCDVWVGTQVPTRARDAAAHVSGLPADKIKVHNHLLG
GGFGRRLEIDMVSQAVKIARQVNAPVKVVWTREEDIRHDMYRPYYYDRISAGLDANGKPI
AWQHRIVGSSIIARFAPPAFKDGVDPDAVEVAADLPYDLPNQLIDYVRQEPRHVPTAFWR
GVGPTRGTFVVESFIDELAAQTKTDPVAYRRALLGKSPRALNVLDVAAKAAGWGETLPKG
QGRGVSVMHAFGSFLSMVADVVVEDGDVRVTRVVCAVDCGMVVNPDTIEAQIQGGVVFGI
TGVLYGEITIKDGRVEQGNFTDYRILRIDQTPRIDVHIVKSTEAPGGIGEPGTAALSAAV
ANAIHAATGKRLRKLPVGNQLKTA
>A0A1C3HAR4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia marcescens|TrEMBL
MKFNLNGQAVEFNGEPDTPLLWVIREHFKLTGTKFGCGIGACGACTVHVDGKAVRSCCYP
LQLVRDRQVTTIEGLSTDRSHPVQQAWIAEDVPQCGYCQSGMIMAVSALLAEHPKPDDRQ
IEAGLTNLCRCATYHRIRAAVHRAADKGES
>A0A117ECB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces scabiei|TrEMBL
MARQLSRRKFVVYTLAASTLTVAAPLGCDAAPAQGAEPSADVTRRPSDVLVTGADEEMLV
LEVTQANKVVVRLPRVEVGQGVTTAVAMMIAEELDARLTDVEIPLADARARGNQFTGGSS
SVSSLYGPARELAALARAKLVTAAARRWKVPARTLRTRNTEVVAPDGRRATYGSLTASAA
GIGRPAVSATPKPASRHRVIGKATTRIDARDIVTGKADYTGDLTVAGAKPTVVARPPTLG
GKALSVDAKAARGMPGVHAVVEIAGGVAVVAETFHHAFEARDALRITWAPGPLVPLSDAA
IRSRLRAAVPRLGTPPRGSAQTEAEFEFAFVGHAPMEVLTAVADVRATRAEIWFSSQSPM
DARDTIASEVGLSPSKVKVHVVRGGGSFGRRLNHDAAIEAALISKAARLPVKLMWSRADD
LRHGRMRPASHHRIRASHARGRVVAFAHTMASVSEAYEEQGFSGRGGTRGPVRGRVNQAV
ARAAGPLPSDSGLYNFGRVTGDSGSVDLAIPLGAWRSVDSGTMRTAEEIVVDEVARSLGK
DPVAFRRATLRSKAVKAVLDKVADAGRWGRALPDGRAQGVAVHEEYGSCVACLVEIDATD
PKNPRVTKAVMAADVGTAVNPRGLEAQLMGTAIDGISTVLHAGLHIDRGAVRESSYADFR
YARQRHAPLRFEAHIMPSRREPGGAGELGVPAAAGAVANAYARATGTKPRRFPLDF
>A0A7Y9R2I9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphaerotilus montanus|TrEMBL
MLNHATHPMHELPRALQHLLARDHDAASAEGLPRRAFLKLGAASGFALGMFPLLAQAQGT
AAEAALKPVQQPGAFVAIAPDGTVTVTVNRLEFGQGVQTALPMVLAEELDADWSLVRSQL
GTNDPAYADPLWGMHLTGGSTAIKHSFTQYRELGARARAMLVQAAAARWGVDAASLRTQN
GAVLGAAGQRLGYGALAEAAMALPVPASVTLKDPKQFRLIGQPTTRLDAVAKSSGRQDFG
IDVRRPGQLTAVVARPPVFGARLRSVDDRAARAIQGVKAVLRVPLDRGAEGVAVIADGYW
PAQQARQALQLDWDTSAVEKVDSTRQLAQYRALAAQPGPRHFDADMAPLAQAPKTIEAEF
VFPYLAHAPMEPLNCTVEFTAQGATLWVGSQMPGLDGMAAARTLGLKPEQVRVQVQSAGG
GFGRRAIPSSDYVVEACTIAKAAQSAGVRAPIQTLWSREDDIRGGYYRPMHLHRARIGFD
AAGQVLAWDHVIVGQSILTGSPFEAGMVKNGIDHTAVEGMRAPYPLPMRLTVHHPKVNVP
VLWWRSVGSTHTAFVMETLIDQIARETGQDPVAYRMKLFGSTHPRHRAALQLAVDRSGYG
QKRLAAGRAWGVAVHESFDSVVAYVVEASMKDGQPVLHQVTAGVHCNLVINPRTVEAQVQ
GAALMGLGMCLPGAAITLKDGVVEQQNFGDYTVARIADMPTIAVHTVPSAEPPTGMGEPG
LPPLAPAFANAVSRLTGKPLRELPFRLT
>A0A1Q8M144|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae717_Ps2|TrEMBL
MSAPTRARAERRDVSRRRFLGYLVAAPTLVVAAEVGRQQLFAPPGASAAAIPSPPQVADA
YDLLDAIRDSSRPTSALVRVEVNRDGTVSFELPRSDNGQGIITSTAMIIAEEMDLDPDQV
RVTLADSRPELVFNQLTGGSSTTFSTYTPIRVAAAIAKGRLLDAAAALLQQDANTLTSRA
GLVTGAGGSAIPFGELTEAAAVDATRSVEVVLKPREEFTVIGTDRRNAQARDIVTGRKQF
IADLKIPDALPTVICRGPGLNCAPLSVANADEVRSMPGVTDVVDCATGVAVRAHTYGQAV
DGVNALRVRWDAGTVEGESDESVLQKVRAAELPLAVPSVPGETVEGDFTFYFRSSSALET
NTAIADVRDGRCEIWTSLKIPITVQHDIAEQLGLPVNAVTIHIVPGGGSFGRRLFGDAAK
EAAEISQKLGKPVKLIWSRADDSRQGRVHPMATSRIRAVVSGESVVSFEQRHTGVACDFG
HGFGDAVTAAAAKAPLGQVSVAEAIWELTQATPYDFGVQTRLLNEVDMRFNTGSMRNVYS
PDVCTARDLIVDRIAEKMGKDSYEFRREFLRNDAMRAVLDKVAEEGDWGRSMPDGTAQGI
GFHVEYKGFAACLVEIDCRPQTVDRKVRQARTGPRVTKAVFAVDGGLVINPLGFKAQIMG
GINDAIAMTLTAGLHLVDGHFVEASWDNYFYTRQWNTPPEMNIVLIEDSEAPEPGGAGEF
GVAATCGAIACAYARATGTVPTQFPILHNEPLPFEPYPTIPPVPPSPTNGLAFAR
>Q3IXF5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)|TrEMBL
MTMLSRRRFLASTAGFTLALVLPTPFARAQGAPPDLPATPNAFIRVGADDTVTVIIKHLE
MGQGPYTGLATLVAEEMDADWSQMRAEAAPADDALYKNLAFGAQGTGGSTAIANSYIQMR
KAGAAARAMLVEAAAEEWGVAASEIAVRAGRLSHPGGKEAGFGAFAAAAAERAVPQDPPL
KDPSQFVLIGGTGKRLDSAAKSDGTAEFTLDIYREGMLTVVVAHPPAFGATVASYDDARA
LKVKGVEMVRQIPEGIAVYARNTFAAIKGRDALEIRWDESKAERRSSSAMLEDMAGALAE
ARVVEESGDKGAIEGAAEVLQADYRFPYLAHAPMEPLDAVIEVKEGRAELWYGCQFPSID
RPTVAQTLGLPMESVRINVLLAGGSFGRRAQGNGHLAAEIAHIAQAAGRDGAFKLLWTRE
DDLKGGYYRPMTLHRLRAGLDAEGRIVGWENAVANQSIMAGTALEAFMQDGLDPSSYEGS
NDLPYDVGARRISWARVESPVPVLWWRSVGHTHTAFAVEVFLDEVLERAGKDPVQGRLDL
MTPEAGRYRGVLEKVAEIADWQGRTREGRAYGVAVAKSFGTYVAQIVEVENGGALPKVTQ
VWCAVDCGVAVNPDVIRAQMEGGIGYALSAALYSAITLDGEGRVQQSNFDDYRLLRIHEM
PQVHVAILPSTEPPTGVGEPGVPPLAPAVANAWRALTGQPVRQLPFAQLLS
>A0A6P2FG56|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. PBS-H4|TrEMBL
MSTLHESSGARQSAGLSRRSLLGLVATVGTAAGGGLLFGFSVPARSQGGARTSVIDGDGV
EMPREGVFAPNAFIQIDRRGKVTLVMPKVEMGQGVYTSIPMLLAEELEVPLASVTLAHAP
PNEKLFADPMLAEQLTGASTSIRYAWEPMRKAGASTRTLLVAAAAQRWKVDPSGCVAREG
RVLHPQTSRSIGYGELVDVAARLQPPQDVRLKDPKDFKLIGTRVKRLDSPEKVNGTAVFG
LDVRVPGMVYAAIATCPVFGGRLAKFDDTHTRKIPDVQQVVSFDNGVAVIGAHTWAARRG
LQALEIQWDEGAGADVSTETIVTDLVKASQRSGAVARKEGDVEKAFANAKTRIDAVYHQP
FLAHATMEPVNCTVRVRPDACEVWVGTQVPGRVADAAAKVTGLPPEKIIVHNHLLGGGFG
RRLEIDMVTQAVKVARQLNVPVKVVWTREEDIQHDMYRPYYYDRISAGLDANGMPVAWQH
RIVGSSILARYAPAAMMKNGVDPDAVAVAAELPYDLPNQLVDYVRQEPRGIPTAFWRGVG
PTRSAFVVETFIDELATHAKVDPVKYRQALLGKSPRALNVLNEATRAAKWTAGAQQGKGK
GRGVSLMHAFGSFFAMVVDVTVDDGEVRVDHVTCAVDCGMAVNPDTIEAQMQGGIVFGLT
AALYGEITFKNGRVEQSNFNDYRVLRINETPNIDVHLVKSSEAPGGIGEPGTSALQPALA
NAIFAATGKRLHALPIGDQLKSNASGGRR
>A0A3G7B073|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGSVVGQNVSTIDNLHSDPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKVNPNPSD
EQIEAAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>B2AIQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MNLHVNNQAVSVECDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHLDGAAVRSCVLP
VAAVSGKRITTIEGLGSAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
SDIDAAITNLCRCGTYPRVRTAIKRAAKALRERRA
>D8P2K0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum CFBP2957|TrEMBL
MRIRNLEALAGGSAQHPAAPASADDGIATLERRNFLKITALAGGGLAIGVAPVLTGAQEA
KAKPPSPPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAMLAPAG
EPYKDPVYGIQITGGSTALNHSFAQYRELGARARTMLVAAAAERWKVDPSTCRTANGVVT
SGSNRATYGELAQAAMALPLPQQVTLKSPSRFRIVGKPTPRLDARGKLDASLKFSIDTRL
PDMKVAVVARPPRFGGKVAKYDAAAAKAIKGVVDVVQIPTDRGGTGVAVVADGYWPAKLG
RDALQVTWEDVGSRVSSAALMGEYKKLADQSGVVVKAADVSAIPSAAKRIRADYEFPYLA
HAPMEPLNCTVDLQREGGNISGAKVWVGTQFQTVDQGALAKALGVAPEKIELNTMMAGGG
FGRRAIPTSDYVVEAANVAKAYAAAGHAGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
SGKVLGWNHVIVGQSITKGTLFESYMLKNGADATMTEGVIENDYGFPMQVSVHHPNVDVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPVAYRLARFTGKEHARHRQALQLAVEQSGY
GKRKLPKGQAWGVAVHESFESVVAYVVVVSIDQGRPRVHRVTAGVHANRVINPLGAQAQI
QGGCVFGLAMIAPGFAIEIENGATRNSNFTDFPPVRMPDAPPVDVFFVPSEDNPTGLGEP
GVPPIAPAVANAVFTLTGKRLRKLPFDAV
>A0A833J1K8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MAQQMSLDVNGNATRVTVDDPETPLLYVLRDDLGLHGPRFGCGLGQCGSCTVHIDGQAVR
SCITPVSGLKPGAKIVTLEGLGGPDKLHPVQAAFIEEQAAQCGYCINGMIMQSAALLNET
PNPDEAAIRQALAQNLCRCGTHLRIVRAVQRAAGTL
>A0A5E8AG53|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. EC-HK134|TrEMBL
MQLTVNGTAHSLEDLEPEMPLLWALRDVLGLTGPKYGCGIAQCGACTVHIDGVATRSCQV
AVGDVWGPVTTIEGLGTPNAPHPVQAAWIAHQVAQCGYCQSGQIMQAASLLSETPDPTDT
EIDDALSGNLCRCGTYPRIREAVKTAARTLKGA
>A0A833J191|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MNAPTLSRRSLLLQGGALVVGFSLTGRDALAQQVFAPVATDGFSKPVAPDQVDSFLALGA
DGRATIFSGKVDLGTGIKTALAQMAAEELDLPLDRVSVVQGDTALTPDQGPTYGSLSIQK
GGVEIRQAAATARARLVRLAGEQLGLPAEALVSENGTVRPKAGGSGLTYGELVKAGRFDL
KVDPTVTTKDPATFALVGKSVARIDIPEKITGRFTYMQDYRVPGMVHARVVRPPAIGAEL
QSVDEASVADIPGLIRVVRQGNFLAVVAEKEWAAVKAAGQIKATWSRWEGLPEQDKLWQH
VRATRVTKDDVTSSTGDAEAALGQAARVLEASYDFAIHTHGSIGPSCAIAEFKDGLLTCW
TASQMTHALRKQLAAMTGLRPEAVRCIYIEGSGCYGRNGHEDAAGDAALLARAVGRPVRV
QWSRADEHGWDPKGPPTLIDLKAGLDGDGNVAAWSSQFHVPEGAAGNVPLVAADLAGLPH
ETTMSPGNIIQNSALPYAFPNVRTVCHRLAATPFRPSWIRTPGRMQNTYANEAFLDECAA
AAGADPLEYRLRALKDPRGIEVLKRVADIAKWQVRPSPRNEASGDVLRGRGLSYVKYELN
RTYVAGVAEVEVDRRSGQVRVPRFFVVQDCGQIINPDGVRNQLDGNVIQTVSRVLLEEVT
FDRGAVTSLDWVSYPILTFPDVPEVVIDLIDRPTEKPWGAGEPSAAIVPAAISNAIFDAT
GARLRSVPFTPAKVKAALQAT
>A0A381A2G7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella pertussis|TrEMBL
MHGSIGPSCGLADYRPDGLTVWSGTQNPHMLRIDLDRLLGLGESRIEIVRMEAAGCYGRN
CADDVCADAALLSRAVGRPVRVQLSREQEHAWEPKGAAQLMEVRGAVDAQGGLAAYDFAT
RYPSNDAPLLALLLTGTLAAEPRTLQMGDRTAVPPYRYDRLRVVCHDTAAIMRAAWLRGV
SALPNSFAHDCFIDELAERAQADPLAFRLRHLDDPRAIDLLREVASRAGWREGQRGSRGQ
ADARHLLRGRGLAYARYVHSKFPGFGAAWAAWVVDLAVDARSGAITVERVVVGQDTGMTV
NPDGVRHQLHGNVIQSLSRALKEQVSFNQAGVSSMEWGAYPILGFTEVPPIEVVLMPRQD
QPPMGAGESASVPGAAALANALFDATGRRFRELPFTPERVRAALAG
>A0A7W4T1Z9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas umsongensis|TrEMBL
MNSINPVSRRGFLKGSAVLGGGLVVAFVIPGGHRFAFGAENQGEVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAAEYGLPAFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFDMAPSQIHTESGVVIAGDKRVTYGELADDAGKL
PVPDPASIKFKEAKDWKVIGKPTKRLDTPEKITGQAKFGMDVQFDGLMTAVVARPPVFGG
SVKSFEGAEALAVPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVVWEPGPNAGLDSQQL
LESFRKLAATPGTSVSQAGDATVMLGRAAKTIEAEYSVPYLAHAPMEPLNCTVKITKDTC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVSEAVYVAKAAG
EPVKTVWSREDDIRGGYYRSAFLHQARIGLDADGMPIAWKHVLVGQSIMAGTSFEATMVK
DGVDKTSVEGVADSPYFEGLANHLIDLHSPQTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVEYRRTLLKAHPRHLGVLNLAVEKADWKAPLPDGHALGVAVHESFGSYVAHVAE
VSQDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESGITFGLGFTLHSKLTFKNGQVQQSNF
HDYQVLRLNEMPVVEVHIVPSTDKPGGIGEVGVPPVAPAVANAVFALTGQRLRELPLQLS
GV
>A0A7X0NIB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassotalea piscium|TrEMBL
MNPHVLEAMSYANDKQASKKLETLNSQSRRSFLKVASMATGGLVIGVSLPSLGKSDNSVG
ESDFNPNAYIHLFENGDLVLYCGRCEMGQGISTALPGAVADEMEADWSYVTVKQGEGNKE
KYGPQATGGSASIRVMLEPMRKAGATAKMMLIAAGAKVWKTSIDNCYAENHFVINKVNGQ
TLSYGELATLAANSAVPENPQLKTKEQFKYIGKALDRHDQGMVVVGQRTYGVDTKLPGLK
YAAIVHCPVLGGTLKSVDKTAALAFKGVSHVVEIERLNVPFGSVGGVAVVADNTWTAQQA
AKKLVIEWDSGPNNVYNTKSYKEQLVANVKKPAELVLERGNLASAFDNASQKISATYTGG
HLCHAPIEPNASVVWVQKDSCEVWASTQSPEDIQKVLAGFLNRDAKEIKVNVMMAGGAFG
RKFKCDYVHEAAAISQAVNAPVQLIWSREEDMRTGYYHSINAQHIEASLDKDGNVTGWLH
RAAFPAIASLFDPSLDRAPANSLGDVNNHPFGIKNFRSETGEAPAHTRIGWYRAVYAIFY
GFAFGTFIDELAHKAGKDSLRFLNQVYDANKNPEQQEQVQRSKAVLALAAEKSGYGKELP
KGEAIGLAIHHSFQSYVAMAVHVKVDKDNIKVLNVDCAIDCGQVLNTDGATAQMEGAVVM
GMSLSLYTEITFKDGAVVNSNFHDYPVLRINEMPNVNVHIIDSDKKATGLGEPGVAPFAP
ALSNAIFAASGKRYRDLPMKPMSV
>I4KHT0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens Q8r1-96|TrEMBL
MLNEIFPNEHPRALQHLLERDEADGPATLPRRSFLKIVGVGGLALGAFPHLALAQEANGA
AAPLKPTQQPSAFVQIAPSGEVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNGN
SDAAYMDPAFGIHLTGGSNSIKNSYTQYRELGARARAMLLSAAAARWNVDVASLSTQAGM
VLGPAGRKASYGELAEAAMAMPVPEQITLKDPKDFRIIGQATTRIDAKAKSSGQQDFGID
MHLPGQLTAVVARPPVFGARIASLDDSAARATKGVKAVLRIPLDGGAEGVAVVADSYWQA
KLARDALKVEWDASAVEKVDSEKQLAQYRELAKQPGPLHFDADMTPLASAPHQLDAEFVF
PYLAHAPMEPLNCTVQLAGDGAQLWVGTQFPGGDGAAAAKVLNLKPEQIQVNVQTAGGGF
GRRGVPTNDFVVLACEVAKAARTAGVNAPIRTLWSREDDIKGGYYRPMHLHRARIGFDDS
GKVLAWDHALVGQSIITGTVFGGRVKNGIDPTATEGLRNPYPLPMRLTVHHPKLNVPVLW
WRSVGSTHTAFVMETLIDEIARTTRQDPVAYRMKLFGEQSPRHREALQLAVDKSEYGKRQ
LPAGHAWGVAVHESFSSVVAYVVEASVQDGRPVLHNVTAGVHCNLAVNPRSVEAQVQGAA
LMGLSMCLPGGAITLKDGVVQQSNFADFSVPRITDMPAFAVHIVPSAEPPTGMGEPGLPA
LAPAFANAVASLTGKPLRELPFKLT
>Q0KB37|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)|TrEMBL
MIGWAWLPPRQRLASGEPLAARDGQFALNGWIKVASDNTVTVVMNKAEMGQGVHTGAAML
LAEEMEADWSQIRVEPSPIDNLYNNIEGVVANLPFRPDDKGWPRRAAEWFTRKGVREVGL
MFTGGSTSIRDLWHPMREAGAAARMMLCAAAAKQWDVKAEACRAQAGKVVHPSGRSATFG
ELAAAAAREPLPRKVELKDPASYRLIGTRAARLDAAAKLHGTASFGIDVVADAMVYASVQ
MCPTLGGTLRGSPPDDVKKLPGVLDLVALPPLQGGSGGVAVIASDAWIAMQAVEKVQCKW
DEGEAAKLSSDGIRDTLVKALDAADPRVWYEHGNGRAMKQGKPAIQVLYSAPYLAHAALE
PVNCTVLVQEDRAIVWAATQMPGLARRCVAKTLRLDTDKVELRQQFIGGAFGRRLEVDFI
CQAATIAARRKGVPVQTIWSRPEDMRHDFYRPASVSRFEAWLDENRKVIAVRNVSASQSV
LEGVAKRNFGLPDIFLSRLDKSTAEGAFDQAYDWPDVWVGHQTVDLAIPVGYWRSVGHSH
HAFFMESFVDELAVAVGVDPLDYRMSLLRDERQRAVLEQARKMSGWGQPLRKQPGVAKMG
RGVALHESFGSVVAQVAEVSVGNMGQVRVDRVFCAIDCGMPVNPTLIEQQVEGGIVFGLS
AALWQKITLERGKVKEDYYTAFPAMRLRDCPDIQVHVMPSTRPPQGVGESTTPPIAPAVA
NALFHATGERLRDLPLLKTLPPSGACDARPSDQCQR
>A0A089NVR5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium oryzae CBMB20|TrEMBL
MPNLTVNGVTHAVDADPDMPLLWVLRDRLDATGTKYGCGIAQCGACTVHLDGQPVRSCQT
RLGDVGTAQVTTIEGVSGRVAEAVQAAWRKLDVVQCGYCQSGQIMSAIGLLSGNAKPSDA
DIDGAMDGNICRCGTYQRIRAAIHEAARSLA
>A0A165UNF6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio axinellae|TrEMBL
MAISIKLNGETHKVDAEPGTPLLWVIRDHLKLTGTKFGCGVASCGACTVHLDGEPVRSCQ
TYIEDVEDAEVTTIEGLKSTPAQAVQQAWTELDVVQCGYCQSGQIMSAVGLLIENPKPTV
DEIDEYMDGNACRCATYQRIRTAIVRASDIMEA
>A0A0P1H6W7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Leisingera aquaemixtae|TrEMBL
MAISLNLNGQTHQVEAEPGTPLLWVIRDELKLTGTKFGCGVAACGACTVHLDGAPVRSCQ
TYVEDAEGAEITTIEGLDSKVSKAVQDAWVELDVVQCGYCQSGQIMSAVGLLSENARPTV
EEIDDYMDGNACRCATYQRIRAAIQRASEMMEA
>A0A7W6CZN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hansschlegelia beijingensis|TrEMBL
MIDLTINGQPRRYEGDPAMPLLWYLRDELGLTGTKFGCGIAACGACTIHLDGKAARGCVT
PVSAAAGKKVTTIEGLSPDGNHPVQVAWRELNVSQCGYCQPGQMMQAASLLNEKPQPSDD
DIDQEMYGNLCRCGTYPRIRNAIKHAAKSVRP
>A0A375FC09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGTVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLQDSPSPRP
EEIRAGITNLCRCGTYPRVERAILRAATALNAGDPKGRASS
>A0A1R3V364|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium prunaredense|TrEMBL
MISLNINGQEHEVDVDPETPILWVLRDTLGMSGTKFGCGAALCGACTVHLDGEAIRSCST
PVSAVESGKITTIEKTTDGTDRVGAAVHAAWVRHDVAQCGYCQSGQIMSATALLASLSPG
AQPTTEEIDSAMAGNICRCGTYARIRAAIADAASTLV
>A0A833Q1C8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia gladioli|TrEMBL
MSEGIIEAGRASGKTEQAADSSAGISRRRFLQAGFTLGAAAGGGLLLGFALPAAGESGRP
SVIGGDAPDQAPAGLFAPNAFVRIDRAGQVTLVMPKVEMGQGVYTSIPMLIAEELEVPLD
SVVLDHAPADAKAYGDPLLGGGQLTGGSTSIRYAWEPMRRAGATARSLLVTAAAQQWKVD
PASCSAANGAVHHAASGRQAPYGSLVDAAAKLPVPSQVALKTPDKFSLIGKPVKRLDSPE
KVDGSAQFGLDVRLPGMLYAAIVNCPVFGGTVASVDDSAARRVPGVRQVVRLDNAVAVVG
DHTWAAKRGASALVIEWHEGDGAKVSMADIVGDLARASEQPGAVARNDGDVTKAFGTAGA
RIDSIYQQPFLAHATMEPVNCTVQVTGSSCEIWVGTQVPGFAIEAAKRVTGLDASKITLH
NHLLGGGFGRRLETDMIVQALKVGKQVDAPVKVVWTREEDIRHDMYRPYYYDRISAGVDA
NGKPVAWQHRIVGSSIMARFVPGSLKNGVDADAVEVASDLPYAIPNQRIEYVRQEPRHVP
TAFWRGVGPTRSAFVVESFVDELAVRAKADPVAYRRSLLEPTPRARNVLDIVARESGWGQ
TLPAGQGRGVSVLHAFGSFFSMVADVSVENGEVRVNRVVCAVDCGMVVNPDTVEAQIQGG
IIFGITAALYGEITIRDGRVEQSNFTDYRMLRINQTPRIDVHIVKSAEAPGGIGEPGTSA
IAAALSNAIHAATGRRLYQMPVGNQLKQKTA
>A0A1L5PGY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli 8C-3|TrEMBL
MVQLTINGVTRDIDVDPETPLLWALREQAGLTGTKFGCGIAQCGACTVHIDGVATRSCAM
PVSAIDANQEIVTIEGLSADGSHPVQQAWLSLDVPQCGYCQAGMIMAATALLNTTPDPSD
DDINAEITNICRCGTYNRVRAAIKLAAANSSAAQKG
>A0A4P6WAC8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter sp. JH2|TrEMBL
MALSLTVNGQHYSLDVELDTPLLWVLRDELNLKGTKFGCGAGLCGACTVHVNGQPTRSCS
TPVEYLDGAEITTIEGLSENGELHPLQKAWVAEGVPQCGYCQSGQIMTAAHFLANTSSPS
REDIVTAMSGNLCRCGTYSRIVAAVESVVDGVGHFEPEQEEV
>A0A7W5PGV4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK069|TrEMBL
MAALTRRKLLISGGAGVGLVVAWAVWPRRYGAALPTAPGEAAFGAFLKIARDGQVIVAVP
QCEHGQGVYTTLAQIVADELGADWRTVGVEAAPLAPPYANPLGAAALFTDAATHVPERVR
DELWTRDSLLVTAGSSSVRRFEQPLREAGAAARVLLCQAAAERWDADWQQCDTRAGFVTL
GDRRLRFAELAEAAAGGRVPDELPLRLGDEGRLSGESLPRLDSPAKVDGSSNFVADVRLP
DMVFASIRQGPQPGARLLSCDKAAAERVRGLLSVVTTDHWVAAVANNWWSANQGVAALAP
RFARGGAMVDDAAIERALDAALDRAGEPVARIGDAAAALRGAGVIAAEYSVRPALHAALE
TPAATAHWRDGRLELWLATQAPTLARAAAAAAVQLSERDVIVHAMQVGGSFGAALEHDVA
AQAAVLARALRRPVQLCWSRGEALLQDRVRAPAKARMRARLGPRGTILAWHAAIAAPPTG
RALGERLLAGDPLRRLAAALPAGTDRYATAGAVPPYRLPALAVDHHPVALDLATGHLRGG
ADGYTAFFTECFVDELARAAGSEPMSYRVGLLGGDARLARCLTTAAELGGWSGGVPGSGQ
GIACHRMAGSAIAVLAEAEVGEGGAARVSRLVAAVDAGRAINPDVVRQQIEGGLVFGVAA
ATGTAAGYKDDLATVRHLGALDLPTLATAPEISVELIASGADCGGISDLGVPAVAPAVAN
ALFAAAGTRRRVLPLRSS
>A0A0N0E1X6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fuscovaginae|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIEADEVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHSAVHELATQKGEA
>A0A0P8BSS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Porphyrobacter sp. HL-46|TrEMBL
MADNPNPNMEEIKTDPALETPVKKKGVKRRIFLVGSALLVGGGAFGLYWSDSSARARAKA
LTTGKGEHNFLSWMKIAEDDTVTIFSPHIDMGQGTHTALGLMLADELDAAWDKVKVEQAP
SDIAFSNTALVQSFLGEMSGYPGVINALPAAVIGMLTRSQKIQITGGSSAVRFTGQGGMR
VVGAAVRLALIEEAASRLGVPASELTTADSVVTHAASGRSLRYGELAAGAAERSFSTDPV
LKSRKDYKLIGKPVNRLDIPAKVDGSAVYGIDFTLPEMRVATIAAAPVRGGKLESVDEAP
AMAVPGVEKVVTLDGAVIVVAKGYWQALKGLDALSPKFTDGGHSAMSTTSIYAAQDRLRG
SGKPDGEAGAGDVDAAFKAAGDKTVTADFRVPFLHHAMMEPFALTAHFKDGKLHMWGGLQ
DPIGARDRAAKAAGLDIDDVIFNPMIMGGGFGRRFPGVTEIIDQAALLAKQVPYPVKLVW
SREEEVRHGTYRPQSSARLSATLDDDGRIAAWRTDYVQGDNSESEAGFIYDVAATSRRHF
AYTSNQIDGPWRSVNSTQIGFYNESFIDELAHAAGEDPYQFRRKHLPEGSRHQKVLDTAA
QRSGWGTPLPEGTGRGIAIVESFGTIVAEVIEATVKDDGSPRVLKAWAVVDCGTTVNPLN
AEAQIAGGMIMGLSSAIGEAITLDKGAVVESNFNDYNLLKLADAPPVIDVHFIESDAPMG
GIGEPGVPPASPALANALFAATGKRIRTLPLLGQAAKA
>A0A841HHD5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MELQLLVNGEQRSVEADADTPLLWVLRESLALTGTKFGCGIAACGACTVHINGTAARSCS
IPAAAVQGQAITTIEGLAGGAERHAVQQAWIEHQVPQCGYCQSGMIMAAASLLAKNSNPT
DQDIDAEITNLCRCGTYERIRRAIHAAALNISRGDVEATRGEESKEARHG
>F2R5L8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)|TrEMBL
MARRHPVRDDHPTSGTGDRTARTEGADGADAPGVSRRRFLGYVLAAPTLTVAAQLGAEAL
APRQAAAAVPALVPSLPGPAELLDLNELLTLAALPTSHLITIRLEADGTAHLALPRAEVG
QGITTSSAMIVAEELDLPLDKVRVTLADARPELLFNQLTGGSNTTYSTYRPLRVAAAVAR
GRLLKAASLVLGEAVGTLTTKAGAVLSPAGALLGYGELAVKAAAVSDTAVAVTLKDPDRF
RIIGTGQRRVDALAAVTGRKKFAMDLQVPDALPTMVCRPPTINGTVRSVANLAEVRALPG
ITDVVTVSTGVAVRGRTFGQCIDAVRALRVDWGPGTAEGASDATVLAKLRRAELPLVVPP
LPLLTKAVDARFTFHFASNAALETNCAIADVREDSAEIWGSLKAPIVAQEQIALKLGLPV
SAVRVHVTEGGGSFGRKLFHDAAHEAAEISRAMGKPVKLMWHRTDDFRQGRTHPMSTSRV
RATYTLGEVLTYEQRHTSVATDFGHGIGEVLTAGVAQLPVADLTFSETMFQLTQISPYHL
GVTTQLLAETDKGFNTGSMRNIYSPNVRCAQELVMDELARRMGQDGYALRRRLMKDPRAR
AVLDKVAEVGEWGRSMPAGTAQGIAVHTEYHSVVAMLAEIDCRPETTGRKIPGAVTGPRV
TKVVCAVDVGLAVNPRGLEAQMMGGISDGIAVTLTSGLHLRDGHFLEGSWDQYFYTRQWN
TPPELEIIVMPPTGDKPGGAGELAVAGAMAAVACAYGRATGTMPTVFPVNHADPLAFTPL
PTVPPVPASPTDGRDRAL
>A0A2H5XN52|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR18|TrEMBL
MARFELIVNHTRHTVDVPPDMPLLWVLRDVLGLTGTKYGCGKALCGACTVHLSGTPVRSC
VLPVSAVVGQPVTTIEGLDPQGNHPLQQAWRELNVPQCGYCQAGQLMTAAALLRQNPNPT
DEEIIAAMGGNLCRCGTYHRIRQAIHRAAALMRQEGAP
>A0A7W5MRF1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. BK369|TrEMBL
MPVSLTIDGKQRTLAVAEDMPLLWALRDIAGVTGVKFGCGVGLCGACSVLVDGQRLFACQ
TPVADVAGKAVTTIEGLTGQPLGQALAAAWEELDVVQCGYCQPGQIVAAAALLKANPKPD
DAAIDEGMSGNICRCGTYNRIRAAIHRAADTIKA
>Q48A69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Colwellia psychrerythraea (strain 34H / ATCC BAA-681)|TrEMBL
MNAIENVSRRGFLKVAGITSGTFVLGMNLPLATAQVKSSTAALSHELNFFVSIASDSMVT
LVCHRSEMGQGIRTSVPQIIAEELEADWQKVTVVQAKADAKYGSQGTAGSASIRSHFTSI
RQIGAVARDMLEQAAANIWQVQRNSVKAEKHFVVHTATGEKISFGELASHAAKLTPPDSS
KVKLKNSADFSLIGKDVKLVDLDNIVAGKAQYAQDIQLPDMLIATIVRPPVVGGSLVSFD
ASETLKIKGVVDVIALKPRGIPVTTNPLSGVAVLADNTWAAIEGRKKLKIKWQHGDKASH
NSAKFIKQLAKQVNQQGEMVAKKGDIYNHKYLDENTVEATYTVPYIHHAPMETPAATAIV
KGKKCTIWAGTQNPQWAKSNVATELGLGKDEHDNIELNVTLMGGAFGRKSKADFIIEAVE
LARASKRPVKVIWSREDDIQHGFYHSISANYCKAELTGNGSADYWVSRNAYPPIGWLWNP
EAKMPSDDQLALGFGDIPFALNNLSIEKHAVDSFVRPGWVRSVACINNGFALGSFVDELA
VKAKLPTRQMWLNLLGDDRHVDPNKNGFKYSNYNLSLTDHPVDTKRMKDLINLISDKANV
EQELPENQGWGISFLRSFGSFVAAATKVEVVNNKVTVLEMHTAVDCGIVVTPDRVKAQME
GAMVFGLSIALMGEITVDEGKVQQSNFHDYPVTRMNQVPEMHVHIVKSDAPPGGIGEPGV
PPVAPSITNAIYHASKTRIRDLPVNKVFTV
>A0A6G8NU51|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Caballeronia sp. SBC1|TrEMBL
MRDASKPAAALVESREVSRRRFLKQGSALLAAGVAVGFRLPDARASEASGVVSTSNATHE
FEPNAWVRVLPDDTIKLVVHKHDSGTGTRTALAAIVAEELDVDPFAVDVITPENPFYMVY
IHPLWKVFSTGGSTSVSLEYDRLRLAGATARAMLVVAAANQWNVPAASCSTANGYVEHAA
SGRRANYGSLADAAAREPAPKDVALKDPAQFKYIGKLQKKRGAAQKVAGTFQYSIDVDLP
GMLVAVITRAPVIGARVRSVDSSNALKLPGVRSVIEIPGRPDVLGGNQAGVAILADDYWS
AHQGQAALQIEWDDSLFESFNSDALAGHQAAWLDSPAAHVVPTIQSGDAKAAWTHPARVI
EASYSMPYKAQNPMEPVNVTAWARKDSIAYWGGIQVPSTAQEAAVVIGGFKGDQVTVHEL
VSGGSFGARESKYWLFEVTYLAVKTGKPVKLMNNRETEMGALFYHAATYHRAKVALDEHG
RLAALQLRAVSPASPEQWEPGYFDRADRMDYSTTEAINAREFTYRAPHLDIGWVRHETGV
PTGWYRAVSYIPNVFAVESIIDEAAHLGKQDPLLFRLANMHDQPRHAAVLRRAAERAGWQ
DPLPAGVALGIATNQAYGSYVAIVARVAKKDGAIVIEKLTCVADCGLAVSPGGVEEQLYG
GLMWGLGHASFDQIDIRNGRVMQHNFDTYRVARMSDMPAVDIDIVQGDLAKLGGVGELSS
PAVTPAIANAIYRLTGERKRSTPFDLRDSQPRSDDKKTA
>A0A7W7AHX4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas abaci|TrEMBL
MTRFTVNDQPVEYRLDPQTPLLWALRDASNLTGTKYGCGTGRCGACTVDIDGRAARSCQV
SIAQVEGAVVTTIEGLSHEREHPVQRAFLAVQVGQCGFCIPGFVMAAAALLRRDPNAGEE
MIRATLTNLCRCGIYPRIVEAVRRAGRLQRGEDVIPAGARPGIDPAEAAGSVPALVAPAK
LSDR
>A0A6J4JPD7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Acetobacteraceae bacterium|TrEMBL
MATLVVNGTERRYDGDPDMPLLWFLRDELGLTGTKFGCGQALCGACTVHVDGAAVRACQT
PLSALDGSKVTTIEGLSPDGEHPVQAAWRDLNVSQCGYCQTGQIMQAAAFLKDTPNPTDD
DIDSAMTGNLCRCGTYPRIRAAIKQAAAKGGKT
>Q39G65|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MIAITVNSVQHTLDIDPTTPLLYVLRNDLHLHGAKFGCGLGQCGACTVIVDDKPMFSCLI
PIAAIGQRHVRTIESLGTLERPGPLQRAFIDHQAAQCGYCIAGMIMRAQALLERNPHPTE
SELRAHMEPNLCRCGTHMRILAAVRQVAGLQQPENASEPVTVSKAL
>A0A222E878|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Antarctobacter heliothermus|TrEMBL
MATTLTVNGTAQEVDLPENVPLLWALRDALNLTGTKFGCGVSACGACTVHIDGEAVRSCQ
IPIGDVWGKVTTIEGLGTPDALHRLQKAWIDHQVAQCGYCQSGQIMQAAALLAETPNPND
DDIDAAMQGNLCRCGTYPRIRAAIKSAAEGA
>A0A0E0UQ25|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium meliloti (strain BL225C)|TrEMBL
MGILQEEITRRSVIASAGGLVVGFSLGRAFAQELPPATPPAPPVSLPGSLDDERFLDSWI
RIDPDNSVTVFTGKAELGQGIRTALLQVAAEELEVDPAEIRLITADTGRTPNEGFTAGSQ
SMQNSGAAIRNAAAQVRALLLAEAARRFGLAATELRAENKAVLAKDGRRATYGELVSGRM
LHVEAQPQSALKPPGTFRVIGKTLPRVDIPGKVTGQPAYVHDLRLEAMLHARVVRPPSPA
ARLTEVDASAAEALPGVASVVRDGNFLAVVASKEFQAVNAMRALAAAARWQESETLPDQT
DLPAELQRLESEAGTVAETGMLSSDGKIFEATFSRPYQIHGSIGPSCAVAQMKADGTLDV
WSHTQGVFPDRAAIAEMLAMPEDEVHVIHMEGSGCYGHNGADDAAADAALIASKLPGKPI
RVQWMREQEHSWEPYGPAMLMKISAALDDQGRIASWAYHLWSNTHSTRPGGAGALLAARH
KAEAIQPKPAKLNISPSGNGDRNADPLYVIPNKRVLWHFLADMPLRVSALRALGAYANVF
AIESTIDELALMADADPVEFRLRHMEDPRARAVIELAAQRFGWDKAQMPRNRGRGFGFAR
YKNLAAYLAVAMEVDVEPETGRVHVIRAVSAIDSGEIVNPDGIRNQTEGGILQSISWTLY
EAVAFDRTRITSTDWSSYPILRFASVPESVEIHIVERPGEPFLGTGEAAQGPAAAAVANA
IRDATGKRLYDLPFTRDRIRSAVGRA
>A0A6S7AFQ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter animicus|TrEMBL
MTAAVQHSRRAFLQGSLGVLTLAVTAKGWVTAAVAAEPDAKAYGADSMPGGTVDDPLVFV
SIASDGAVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVVQAPADESRYGNQNVDGS
RSMRHFLMPMRRVGAAARQMLEAAAAARWSVPIAEVKAEQHEVLHGPSGRRLSYGDLAAD
AAKQPVPAGNALKLKARSEFRYIGKDQVRLVDLEAIGKGQATYGMDMRLPGMVYAVVARP
PVVGGRVRRVDSAKALAVPGVLKVVEIPAMQGAPAFQPLGGVAVVARNTWAARQGRDALQ
IEWDDGPNGAYDSVAYQQTLQAAARAPGKTMRNQGDAANAWTNAPEAERVSAEYYVPHLA
HASMEPPVATVQIQGDRAEVWTSIQNPVAARDAVAARLKLEPANVKVNVLLLGGGFGRKS
KPDFVDEAAIVARAMPEGTPVKLVWTREDDIHHDYLHTVSVERLEAVMNTQGQVQSWLHR
SASPTIASLFAQGAKGQQMFESAMSAINMPYRIPNVRVETAEVEAHARIGWFRSVANIPH
AFAAQCFIDELAHRAGKDPQAFALDLIGPARQIDPGTLADTWNYTESPERYPYDTGRLRG
VIDAACKGAGWGRTLPKGHGLGLAFCYSFMSYTATVVEVAVDDKGEIRVVAVDMAMDCGP
QINPERIRAQMEGGAIMGLSLALTSEITFEKGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHALPPGGVGEPPVPPVAPALCNAIFAATGKRIRTLPVRKLA
>V4YPF7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Betaproteobacteria bacterium MOLA814|TrEMBL
MDLIVNGQNRTVNVASDTPLLWVLRDNLGLTGTKFGCGISACGACTVHLNGQAVRTCVLP
VAAAQGQQITTIEGLSNVAGGGVLHAVQQAWIDEQVPQCGYCQSGMLMAAAALLSSNSAP
SNDDIDAAMTNICRCGTYQRVRAGIHKAAKTLQLSRLPGTES
>A0A1P8USE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger abyssi|TrEMBL
MRYGEVASLPVLATTAGEIAEDSLKSRSEWSIIGTDVDRLDIPDKTTGATQYSIDVNLPD
MVYAVQLLAPVEGETPTINSDEAARAVDGVIDVIALPNSVNVLARSFWAALAGRDVLDVT
WSETSLFRSADSETELENLAAVVDDLDADSVVWEARGEEISDYSADGVITRHYTTEHVYH
AQMEPLNAVASVDADGSGAEIWLGTQSQTVSVAVAAAVLGTTPDRIRLNAMQMGGGFGRR
TWFARELLRDALILSRSSGRPVKLVWTREDDVKQGWLRAATVHRFDAILDNEGTLSAMRH
RIAAPSTFQFVQPDRWDPDVGRDPLIMEGSETRDYDIPAFRAEHLLIPRASRLSAWRGIG
WGPVCFARECFIDELAAQAGSDPVSFRRKLLANSPRGLSVFDAVVAMSDFGNAPEGKAHG
IAFAGYKTGFASGVAEVSHEGGRIRVHRFWAAVDPGLVVHPQSYRSQVEGGILFGISTVL
SERSSFTGGQIDQSNFYDYEPIRMYDVPDIEIRLIDSGNPPSGGGEIGVPMAAPAVANAL
RALTGSAPSHLPFSSGA
>A0A1X7AGU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Parendozoicomonas haliclonae|TrEMBL
MSEPTVSSSLSRRGFLKASMTAGGALTLGFTIPSISSAQDQQESWQANAWLEVDKDNQLT
LIIDRVEMGQGTMTGLTTLVAEELSTSPDAILTRFAPAAKEYRNPLFNMQMTGGSTSLAV
AWTHLREAAAAMGWLLTSSAADIWQVPHRECALSQGHVVHPAHGKLPWSQLIGVAQHKKL
PSDIPLKPAGEFRYIGKRNQRTDAAPKSFGQADYGIDTKLPGMVHAVVIHSTYIGGTLKS
YSADKAKNSAGVIDVFPIAQGIAVVAEKYWQARKAALLVEAQWEPGETGETSSEDIFNHY
RQLLDEDDAKVIQREGYPNRVRKNASQLITAEYQVPFLAHATLEPQNCVAHVTDKGVEIW
APTQAPDLAQVAASRVTDFSPSDVTVHTTFLGGGFGRRLIQDFVEEAAAIAHRVKRPVKL
LWSREDDTRNDHFRPAAMHRMTGSIDGNGYPELWHHSIACPTLMDWIVKDAAPAMFAGMP
KWTFGTLANVGLAAQGTLAPDDHSPWEGADTISYALPNLMLDYTKAENTIPVTYWRSVGN
SHTSFAVESFIDELAHAANTSPLTFRQNLLTDAPRAKKVLNIAAEKAGWGKAPAGRYQGI
AFFFSFNTWVAQVAEVSVSGTTIKVEKVTCVVDCGTVVNPEIVKAQMEGGIIFGLTAALY
GEITVNNGQVQQSNFHDYPLLRMNEIPDIDVHIIDSEEPPTGVGEPGLPPIAPAVANAVF
AATGQRLRTLPLKLSA
>A0A7W6G5H2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MQAELSRRSFLRASALAGGGLLVDFSVPVHAAQGAAVLTAFVAIDTSGAITIAARNPEMG
QGIKTSLPMIVAEELDADWAQVRVEQADLDPARYGPQFSGASMSTMMGYLPMRQAGAAAR
DMLVRVAAARWGVAVAEISTAASVAHHKASGRSLPYAALAQEAAGLAPAKPGDLRLKSPE
QFTIIGSRRGGVDTPKIVRGDPLYSIDTRLPGMLHAVFVGPPSPGAVLRRVDDAAARAMP
GVKAVIPIQGVKAKGTFAGSVDSLTDGVAIVATNWWYAQQARDKLVLEWDESAAQGHGDA
AYAARAKALLDAGGGKVAFKAGDAKAALGKAAKVISARYDYPFVAHNTLEPQNCTALFKD
GKLTFWAPAQQPENGRKLVAQCVGVAEGDITVHVTRIGGGFGRRLMSDFMAQAGAIAKAM
PGVPINVLYNRTDDITHDFYRPAGWHKFKAGIDQSGRLTAFTNHFVSFGPGEDPQFFANM
APFHMPEGLIPDIEMTHSVFPTIMPLGAMRAPTSNAHAFVFQGFLDEVARAGGRSLPALM
LDLFTADKQFGETDKAGETPRSFNTARARAVVQKAMAMSDWGNVPRKPGIGRGFAFYFCH
RGYFAEVVEVAVKGKAVTVRKVWAAGDVGRQIVNPLGAEAQVRGSILDGLSQALNGQKIT
IENGRVQQSNFHDHPFARIDRLPPVEVAFVPSDAQPGGLGEPALPPVIPALANAIFDATG
KRLRSMPFAL
>A0A653LRG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. 9I|TrEMBL
MNRMRLVHPKQAKPEEASPAKSGVSRRNFLLGGVLAGGALMVGWGVQPPRQRLHTANPLA
LDGDAMALNGWIAIAPDGTVSVVVPRSEMGQGVHTALPMLVAEELDVPLASVRIAQAPID
KIFANLTVLRENLPFHPDDTGNTRQGAQWLMAKLGRELGIMFTGGSTSVKDAWMPMREAG
AVARAMLLKAAAEQWKQPEARLRTEDGFVVHPGGSRIGYGALAAVAARVGAGIEAGDVRL
KEPREFRLIGKPLARLDSRAKVDGSAMFGIDARPPGMLYAAVKMAPMVGAMLVDYEKAAA
SRPGVIKLVQTPGLGDEYSGIGAGVAVLATSWWQAREALEVLRIRWVVETTEKLSTESVF
EEFARALDGESGYVYHETGTQDVRGAALTVSAEYRAPFLAHAPMEPVNCTAQVVDGKVRL
WASTQVPSIAVDVAARVAGVDREDVSIEVMLLGGGFGRRLEVDMVSQAVAVAMAADGRPV
QLIWTREQDIKNDVYRPAALARFRAHLDAQGNILAWDNKSAGGAIGHQYFQRNLGLPGLG
PDKTAAEGEYDMQYAIANQRIAHVIVDSPVPLGYWRSVGHSHNAFFKEAFLDEVAHAAKR
DGVEYRRALLKEHPRALAVLDAAIARAGQPEAGRAHGVALHRSFGSTVAQVAEVSVEGTQ
IRVHRVVCAIDCGLVVNPNIVAQQVESGVLFGLSAALYGEITHKGARVQQSNFGDYQVVR
MNEAPHVETIIMPSAAHPEGVGEPAVPPVAPAVASAVFKLTGQRLRSLPLRLS
>A0A654DLD9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. 8Z|TrEMBL
MTRLQINGQTKDVDAPGEIPLLWALRDELGMTGTKFGCGMALCGACTVHMDGSAIRSCVT
PISAVTGKAISTIEGMEVDPVGQVVQHAWVENNVAQCGYCQAGQIMTAVSLLKSTPRPSE
EQIDQAMSGNICRCGTYPRIRAAILQAADQLAQGGQR
>A0A0M6ZUI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium album|TrEMBL
MLHLLQKPLEAAKPNRRTFLKMSAGTVGGLMIAMHLPRAAEAATGDSGLVQPFVHIRPDN
TVIVLSKHLDKGQGTATGLTTLVADELDASWDQVSAEFAPSNPQVYANTLFGVQGTGGST
AMANSFMQYRQAGAVAKAMIVAAAAQEWGVPTGEVTVSNGVVSHSSGKSATLGELAGLAA
QQDVPAEPQLKTPDQWVYIGKTFPRIDVKNKTIGAPNTYTMDFQRDDLLVAVVARSPRFG
GKLKSFNASEAEKVPGVVKVLQIPNGVAVVAESTWPAIKARDLLEIEWDDGDAETRSSDA
MMAELKELTAKPALKVREDGDVDAALEASASVIEADFEFPFLAHGAMEPLDAALLYDGET
AELWLGSQIQTIDHNVAATILEVPFEKVKVNTMWAGGSFGRRAQADSHPVAEVAFLAKAM
LAAGMDPAPVKIIWTREDDMAGGYYRPMSAHKIKVGFDGDNNVTAFKYNIAAKSIIKGTP
FEAMLMKDGVDHNMTEGAHDTTYAFPLMNMDQAFQETKVPVLWWRSVGHTHTAYVMETMM
DRLAKQAGKDPVTYRLEMIKDDPRKVEVLKLAAEKAGWDQPAPEGRYRGVAVHKSFGSYV
AEVAEISLRDDGTVKVEKVVAAVDCGTPINPDNIRAQVEGGIGYGLGAILRNQVTLADGI
VEETNFDTYEPIRISDMPEIEVHIVASNEAPTGIGEPGTPPIGPAVANAIAAAKDEWVTN
LPLTKAGLV
>F7RQB1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella sp. HN-41|TrEMBL
MAEVLSTQAVVKEASTIASTQTLSINGKSFTLDADPKMPILWALRDMLGLTGTKYGCGAG
LCGACTVHLDGQPVRACLTSLGQAQGKRLTTIEGLDNQKLKNAWAEHNVPQCGYCQAGQL
MSAAALVAQHPKPTEEQINSAMSGNICRCGTYPRIKAALQDYAKQEG
>A0A653LJS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. 8O|TrEMBL
MITLNLNGKDHELDVAADMPLLWALRDVANLTGTKYGCGMALCGACTVNVEGQPTRSCVT
PVSAVVGKRISTIEAVGEDAVGKVVQEAWRQLDVVQCGYCQSGQIMAATALLSSNKTPSD
ADIDAAMSSNICRCATYVRIRAAIHEAAGKLA
>A0A7Y9IRP9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pigmentiphaga litoralis|TrEMBL
MPDNTVTRRMFIAGSGVAAVGVAFGAWKWMGEERAQASTGVLAAEPISVFNPIAWVSIAS
DNTVTIYSPAAEMGQGTMTSLPRVLAEELEVDWNTVRVEQSPVNPGAFGNPGFGGAMVTG
SSRTVRGYYLPLRLAGLQAKLVLVQAAADIWGVPPTEILAEKSVLTHASSNRRMTYGELA
KVATAPATLPVVDKSMLKPMSAFTIIGKDVPRVDVPSKSDGSAIFGIDVRLPGMLWAAVK
YAEVQGEKPLSVDVTKAEAVSGVRKIITLPYGVAVVADSFVTARTARDLLAVTWTQEAPG
RSYDSDRAMTEYVTRAKHLTEAGTAWSKRGDAQSAIDGAARTMSATYLSAHVAQVTLEPM
NCTAWVQGDRIEIWAPSQIPSGVLGVAVQSGFRAENVKVNITLLGGGYGRRAEVDFAIDA
VLIAKQMPDIPVQVIWTREDDFQRSKPRPMTAQHLTAGLDADGRIVGWRHRITSEGATIR
LARALYDATGGKDPTVMKGSENVYDIPNQLAEHLPEKRGIDVGYWRGVGPSYTKFAAETL
VDDIAVQLKKDPLQYRLDMLSASPRAQAVLRRTAAMANYPVSRGAGRALGLAFSDAYESF
IAMIVDVSIVEGKIVVHEVWAAVDCGHAISPANIKTQIEGSALYGLSAALGEKLDYKAGQ
VQQQNLHGYPILRSSGTPLVNVEVIPTDNPPEGIGEVGLPPLAPAVANAIAQLTGRRIHT
LPFPATV
>A0A2Z4LWM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda aurantiaca|TrEMBL
MPTYQIKVNGESKTVDVAADTPILWVLRDHLDLVGTKYGCGIGQCGSCTIHVDGTAMRSC
SMTLDQVDGKSITTIEGLSKDGKHPVQEAWKEVDVPQCGYCQAGQIMTASALLESNPKPT
EDDVKNAMHGNICRCASYTRIRKAVMSAAENMD
>A0A0B6RZY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia plantarii|TrEMBL
MKPLATPASAARRRFLTEGALVVGFTLAPALRAVAQKTTTEAGSFTASAPTLPGSLKLAP
LLDAWIRIDEHGITVCTGKVELGTGIRTAMIQLAAEQLRVGVDAVTLVTADTRLTPNEGY
TAGSHSIADSGTAIFNAAAQARELLVETAAHKLGVAPAELRAGDGKVVANDGRALSYAEV
VRDVNLHRNAAARTDLGAPSAWRVVGQPVPRVDIPGKVSGGPSYVQDLRLPGMVHARVVR
PPAYGASLISADLDAVRAMPGVIAVVRDGSYLAVVARDEWEAIQAMRALSASAQWRPGPA
LPDQATVHDLLMTFPAEDIAVAGRAAPAGAAVTTRSARYRKPYLSHGSIGPSCAVAHLDG
DTLTVWTHTQGVFPLRAGLAEMLSMPPERIHCIHVEGAGCYGHNGADDAAADAALIARAV
PGRPVRVQWMREQEHGWEPFGPAMTTRVSAGLDAAGRIVDWHYELWSNGHNNRVENAGRL
MPTWLLAQPFTPKPQKEIPMPEGGADRNSVPLYTIPNLVVTDHFIQTAPIRVSAMRGLGA
YMNVFSTESFIDELAHAAHADPVAFRLAHLGDARAIDVIRLTAARFDWPRRPAGGRGHGT
GFAFAQYKNLMAYLAIAVELTVDADTGEVALGRVVASVDCGQVVNPDGVKNQIEGGIVQS
ASWTLFERTTFDTRRVTSFDWSTYPILRFGSLPRSVEVHLIDRPAMPFLGVGEAAQGPTA
AAIANAIFDATGKRIRETPLLPEKLRG
>W7VR31|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium sp. T29|TrEMBL
MALHESFGSIVAQVAEVSLAAGGVPRVHRVVCAIDCGTVVNPGIVRQQMEGGIVFGLSAA
LHGGIDIVAGVVQQKNFPGQPLLTLAESPRIETHLVASEHPPGGVGEPGTPPIAPAVANA
LFVLTGVRRRGLPLRG
>A0A846R6J1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Micromonospora profundi|TrEMBL
MVERNSRGRFPGYVLAAPVLVTAAELVTTPGAAALPSSDPMELLGLNDIMTAVALTTSAL
IAVEVSEDGTVSIAVPRALMGQTATTSTAALIAEELSVPRGRIRVALADARPERAGTPAA
GGPSYAPIRVAAAIARQRLLRAASTMFDVPLGDLRLEAGFVTDGAGRRVDIGALATRAAS
PSTLAVAVELAPRDGRTFVGHPAVGPARGR
>A0A7X0CPD2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mucilaginibacter sp. SP1R1|TrEMBL
MNYISRRHFIKSAGTAGFALWLGLSAKGEILKVSASVESKNFSPFIKIEPNGQITLFNIK
PEMGQGTYQSIPALIAEEFEVSLDQVIIKNTGGEKEFGNGQRAGGSTSVRGSYTEMRKVG
AAAKAVFLTAAATKWKVDESTCYAENGKIIHRPTGKSETYSELLEEASKIELPKEPKLKE
PKDFKIIGKQAHRPDVPMKTNGSAIFGIDVQVPDMVYATVERCPVIGGTLKSFDATEALK
MQGVLKVDKVERIVGIYSYIGVAVIANSYWTATQARKKLKIEWDTKGYETYNSAEYDAYL
WKHADEEGMVDKNIGAIDTVKTSPQTTIDADYETPVIAHHTLEPMVCVAHVTGDKVEIWS
SNQVPNLITAADDNSIPALTGFKPENVKYHNMFIGGGFGRRLYYDYIVEAINVAKLINRP
VKTLWSREDATKKGPWRMMTFSRMSGTLGDDGKLLAFRHKVIGPNFHESLFKNFNKTRLD
PSMVEGIGSQDYQIPNLKTSYIKTDSHIPGAAFRSVVSSTICFPHESFVDEMAYKAGKDP
MDFRLSMVAPTSDTWKLLSKLKELSNWEKTLGKNKGRGVAQWKFFGCQLGYVVEVTHDPV
KGSVKIDKVTALIDLGIVVNPDNVKNQVEGAVIMSISAATKPGITFKNGVVEQNNFYDNP
VPRINETPIIEVHILADGGRMKGVGEPGVPPFAPALANAIFAATGKRFRRMPFDLKNVSK
>A0A377J6I0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia hollisae|TrEMBL
MSVSVNINGQDYELEVPADTPLLWALRDNLMLTGTKFGCGIAQCGACTVHIGGQPIRSCV
TPVSAVAGQNITTIEGIESKAAKAIQAAWEDIQVPQCGYCQSGQIMAASALLTNNPAPTD
ADIDAAMNGNICRCATYVRIRDAIKQAATELKQG
>A0A0D6SXH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. FeS53a|TrEMBL
MSTFEQDAAPETGIFNVSRRTFLRGSGGLALGVLFSPLLDAAELLAGNGSFEPNAFVRID
RSGQVTVIAKHVEMGQGAYTGLATLVAEELEADWSRVVVEGAPADAKRYNNLAFGPFQGT
GGSSSIANAYEQMRKAGATARAMLVAAAARQWQVPADSLRVEQGVISHAASGRKAGFGEL
AEAAARESVPASVPLKEPKDFRLIGQAVPRKDSPDKTDGRAVFTQDFKLPGMLVAVVAYP
PRFGAVPAKVDATRAKAVPGVVEVVEFRDLPHGRAGVAVLAHNTWAARSGRDALAVEWDE
QRAFTLGSEEIFARYRDAAAQPGTVATRQGDVEPVLAKAHQRIEAEFEFPYLAHSAMEPM
NCLVRLSEGACELWNGEQWQTGDQASVARLLGIAPEKVTITQLYAGGSFGRRANPVSDYP
LEAVAIAKAAWDKGVKAPVKLVWTREDDTRGGYYRPAYLHRARLALDAEGRLTAWHHRIV
GQSIIKGTGFEAVMIKDGVDQTSVEGLSNLSYAVPNLQVELSTPSDIGVPVQWWRSVGHT
HTGFAAEVLVDEAATTAGKDPYAFRHGLLEKHPRHRGVLELVADKAGWSRPLKPGAEGEK
RGRGIAVHESFGSYVAQVAEVTVKADGSFRVDRVVCAVDCGLAINPDVIKAQMEGGIGFG
LAAALHGAITLREGRVEQSNFHDYQVLRMNEMPVVEVHILPSAEKPTGVGEPGVPPLAPA
VANALYAATGVRLRKLPFPTQVKA
>A0A087PP28|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MPDMMPPSFLARNPQFSDGFLAILRPPVAVGGLLARSPASSAAPQDEDVFVVVSARGGVV
GYCGHVDLGTGIRTALAQIIAEELDIPFADVIMVLGDTDKAPNQGATIASETIQISAVPL
RKAAAQARKIILSLAADVTGLPASGLKLDAGQVVALKPHALENSIPYRQLLQGKNLTALL
DEAVEVKDPEHYTVVGKKVSRVDIPDKVTGRAVYVHDVRVPGMVHGRVIRPPYGGFDHGP
FVGNSLITVDRASIAHIPGVLDVVVIKDFVAVVAEREEQADAAARQLRVDWHTPDLPDME
DIEAALQANLSTPRVVHDQGDVEVALGQLAHRMDRTYRWPYQMHASIGPSCAVAQWAEDS
LTVWSGTQNPHMLRADIALLMAMPESAITIIRHEAAGCYGRNCADDVCGDAALLARAVSR
PVRVQLTRSQEHVWEPKGAAQLMQVKGGLGQGGVPSVYDFSTRYPSNVSPLLALVLTGVV
PAVIPAVAQMGDRTSIPPYDYDNLRVTVHDMPPIARASWFRGVSAMPNSFAHESYIDELA
VAAGEDPVAYRLKYLKDERAANLLDAVARRAQWEPRTTLPAPDPTLKLLHGRGVAYALYV
HGPFPGKPAAWSAWVADVSVDRQTGQIALTRVVVGQDSGMMINPAGVQHQIHGNVIQSVS
RTLREEVTFDETGVTSRDWGGYPLITFPEVPDIDVLMLEQQDKPPLGVGESASVPSAAAI
ANAVYAATGVRFRELPLTPEKVRSALDEKLGVYVADPLPLPQAPASGLLPPSPAMARKTG
WKALLAAGAVASVVGGFIGSLSPWRAEIAPISRPDPTTWSEKTLEKGRQLAAAGDCAVCH
TVPGGTLNAGGLPLETPFGTIYTTNITPDEETGIGRWSYPAFSRAMREGVGRTGQHLYPA
FPYTAFAKMTEPDMQALYAYLMAQKPVRQTVPQTKLSFPYNIRPALAVWKTLFHDSRPFQ
PDPSQSAEWNRGAYLAEGLGHCSACHTPRNMLGAEKWRSAWLGGGEAHGWEAPPLGNLSR
SPVPWTANDMFDYLRTGFSERHGPVAGPMAPVVAEMVQMPEQDVRAIATYVASFDTRQAP
EDQPQQVVKTAEARAAATAWSGQGARVFGGSCAGCHSGQAPHMFGNRPQLALNTNVVSAR
PDNLVRIVLHGIPASTLPGAGSMPAFAASLSDEQISDLVRYIRQTFAASSPPWQGVEATV
RRIRAEQLHASTGSAVTH
>A0A840NGN8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora gloriosae|TrEMBL
MARRKFLGYLVGGSGLVAAANVGLLGSPPEAAAAVPTAPVPAELADLNDVLSAAALPTSQ
LITVEVHEDGTASFELPRAEVGQGITTSIAMIVAEELELPLDKVDVSLAPARPELLFNQL
TGGSNTIFAMYTPVRVAAAIAKGALLEAASNLLGDTVDALQAKAGEIIGVGGKSVTYGEL
VSKAAVPRTTPREVVLKPVAEYNVVGTPQPRKDARAAITGQKQFAMDLAVDGALPAMICR
APTVHGTPKAVRNAAEVKAMNGVTHVEQVPTGVAVRAQTFGQCIDAIRALQVDWNPGTAE
GESDESILAEVHGAELPMVVPQVPVLTETLDYGFEFYTRSGSPLEPNCAVADIRADGGTV
WASAKSPIAAREEIAAAVGLPVDKLVFNVVEGGGSFGRKLFFDGALEAAHVSKACQAPVR
LMWHRADEPRQGRSHPITTSRIRVTRLADQVLTYEHRHTGVAVDLTHGLGEAITAGAAKL
PVAGNLTFAETIFTTTQYLPYDFGVVDQLLLETGAHDRFPTSAVRNVYSPDVRAANELVV
DRLAERMGKDPYEFRMGFLREERVRRVLEKVAEEGEWGKRMPEHCAQGIAIHEEYKGATA
CLVEIDCRPETVNRRIRDARTGPLVTKVTFAVDPGLAINPTGVEAQMQGGISDGIALALT
NSSHLADGHFLEASWDNSAYTRQWNTPRDIQVFVMPSEHPPGGAGEAGVAATFAATACAY
GRAVGEMPTYFPINHKEPLHFEPKSFVPPVPESPTDGLTHTF
>A0A840NNY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora gloriosae|TrEMBL
MDAELHPVQRAWLDNDVAQCGYCQPGQIMTAVALLRRVAAEDREVTEADLDDIRNICRCG
TYPRIRAAIRDAARDM
>W7WQG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium sp. T29-B|TrEMBL
MEIRVNRLDFGQGALTALPMLVAEELDVDWKHVRASLAPAGEAYKDPLFGIQMTGGSSAV
PNSWLQYRQVGAATRMMLVAAAAAQWKVPAEACSTEAGVVRHGSKRATYASLAAAAAKQP
VPSSVALKAPADYRIIGHGKGRIDAVASVSGKKRYGIDHRLPGMKVALLQRAPTFGGQVE
SFDASKAKAIKGVIDVFQVSTDRGGTGLAVIADGYWPAKQGREALQVKWKAGVGGTVSSD
KLLAQYRDEAKAPKLTALAGDGAAIEAAAKAAPKKISAEYEFPYLAHAPMEPLNATFELK
ADRATVWAGTQFQTVDQTAIAQTLGLKPEQVTLNTLPAGGGFGRRAVPSSDYLREAAGIA
KAWHAKDPKSPLMVMWSREDDIKGGYYRPAHLHRVDIALGAQGQVQGWDHVIVGQSLVKG
TPFESFLVKDGIDHTMTEGVVENTYGMPMRLRATHPDVAVPVLWWRSVGHTHTGFVMETL
ADEVARAAGQDPVAWRLAKLDPKKHARHVAALKLAVDKSGYGKSLPAGHAWGVAVHESFG
SVVAYVVDVSLIDGRPKVHAVTAGVHANQVVNPTAAEAQIQGGAVFGLSMIQPGFAITLK
DGVVEQSQFSDFAPPRITDAPPVAVHFVPSNDPPTGLGEPGVPPIAPAVANAVAALTGKR
LRKLPFEALA
>A0A7W6EQI4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella defluvii|TrEMBL
MALFQLKINGKNYPVDVDANTPLLWVLRDHLDLVGTKYGCGMAMCGACTVHVNGDATRSC
VLPISAVSAANITTIEGLSEKGTHPVQEAWDEVDVPQCGYCQAGQIMTASALLSKNPNPS
DKDIEEAMVGNICRCGTYHRIHDAVKVAATKMKK
>U2EME8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinisphaera shabanensis E1L3A|TrEMBL
MDIQYNEAELAFRDEVRAFVAEKLPKEISDKVKSSEHVSPEDMITWQRALYEKGWLAINW
PEKHGGPGWSPIQKHIFEEETAEAGAPRILPFGLNMVAPVIIKFGTQEQKDYYLPRILKS
EDWWAQGYSEPGAGSDLASLKCRAERDGDHYIVNGQKTWTTLGQHANMIFVLVRTDTTVK
KQEGISFLLVDMENTPGVTVRPLITLDGAHEVNEVFFDNVKVPVENLVGEENKGWTCAKY
LLTFERTGIAGVGISKAALEHLKQIARNEQAEGKPLIEHPRVAERLVELELELMAVEMTN
LRVVSAAEAGGVPGAESSFLKVMGTEVRQKISDLYRELAGPYALPFPDLDVGEDAFGPEF
SASASSTYFNLRKLSIFGGSNEIQKNIISKAILGL
>A0A846QTM2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saonia flava|TrEMBL
MPTYQLKVNGESKSVDVSEDTPLLWVLRDHLDLVGTKYGCGIAQCGACTVHLDGNAVRSC
AMTASQAEGKSITTIEGLSEDGSHPVQEAWKEIDVPQCGYCQSGQIMTASAFLEKNPTPS
ENEIKSAMHGNICRCASYNRIYKAVETASKNMGS
>A0A846R0B4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saonia flava|TrEMBL
MASIKTKIGRRAFIKNTSLASGGLVLGFSILNSCKPKDVEKIAVREMPKEWFEINAYLKI
GDNGLVTIQCPNPEFGQGVMTSMPMIVADELDIIWEDVLVEQAPFNAEKYGWQFTGGSQG
IRRRWEGLRMAGATARHMLKQAAANAWQVPVGEIETTEGVLAHKTSGKSAGYAEMAAAAA
QLEVPEEVTLKEVKNFTIIGHSKKDVETQKIITGKPLFGIDYQYEGALIAMAVHPPAFGL
KLKSFDDSNVRSMPGIVDVFQINTLTDDMTRGYFDTNAFTDLVAIVGKSTWEVMNAKKQL
QAEWEPITDYNFKMDRFGTEVEVTVPKGLESTDGHYAQMTEMASKPGTVARKDGNPEAVF
KNAAKVIERSYSCPFLAHNCMEPMNFFANVTDTDAHLAGPLQAPALAETTLSTRLGLPAE
KIDIEMTRMGGGFGRRAYAHYAIEAALISKQAKSPVKLVYTREDDMTFGIYRPSYHATYR
AALDENNNLVAFHVKAGGVPETPLFANRFPAGAVDNYLAEQWEINSNITIGAFRAPRSNF
MAGVEQAFLDEVAEAADKDPIDFRLELLERAKNNPVGENNDYEPDRLAGVLKLAREKSNW
ANSAPGAHRGVSAYFCHNSYAAHVLDIVMDGETPKVNNVVCAIDCGIVVNPDAASNMAEG
AIIDGVGNAMYGSLTFKDGRTEQTNFDTYKMIRHNEAPKNIEVHFVKNEIDPTGLGEPPF
PPVMGALANALYKATGRRHYHQPFLGKKEILG
>A0A846QU64|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saonia flava|TrEMBL
MSTTKPIEFSRRGFIKTSSLASGGLLIGFNLFNACKPNVAPPIDLSLLDYNDFNAFIKIA
DNGAVTIFSPNPEVGQGIKTAIPMIIAEELDVAWKNVFVEQAPLDTKNFTRQVAGGSQSL
RFGWDALRQTGATARQMLVNAAATKWGVDPSECTTNEGVISNANGETLGYGDVVKEAAMV
EIPEKVKLKKPKDYKIIGTDAHNVDIDKIVTGKPLYGMDFKREGMLHACVLRPPAFGQKL
DSFDDTAARAISGVVDVVQFDDKIAVLAKDTWTAFKGKNALKAKWKEDKKLESSEDHNDI
LDGLLDGKEFNTMRADGDIKKAFADADKVLERTYESPFLPHNCMEPMNFFADVSADKVEL
IGPIQTPERTAKSIADILERDEADVSLEMTRIGGGFGRRLIGDYAIEAAQVSNITKKPIK
LVYTREDDMEGGIYRMAIKYRFKAAVKNGEITGYHLKEASFNSNMYGLIPHFFPAGAVEN
YQVDVANYKSDISTGPWRAPYTNFLASAEQSFFSELAELMEVDQVQLHLDMLQKVKGTTD
DRIQYSPERLENVIKVAVEKSGWGKKEEGVYQGFAGYYCHNSHVAEVADVVIENETPVVK
KITCVVDCGIVVNPMGALNQLEGGAIDGVGHAMYGDLAFKDGKPLSNNFDTFRLIRMKEA
PLVECHFIENEYSPTGLGEPALPPAAGAVANAMKAATGKRIYGQPFTKNPELLTLPKKEI
LG
>A0A2S2DYL0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aquirufa nivalisilvae|TrEMBL
MKKTDNTYSRRSFLKVSSLSGGGFMLGISWLASAKPEETLSALNVEPIWQELTSYIKITP
ENVIKIFSPNPEFGQNVMTSLPMLIAEELDVDFKSIVVEQASYNPALFNRQFTGGSQSIR
SAWKLLRTAGASARQMILTAASQAWNVPVSELTTSKGQVKHAASGKSGSYGSFSTAASKL
TVPKDIVLKANKGFRLLGTPQKNVEGTKIVHGKPLFGMDYTEAGMLIAMTERPPAFGMRL
KLYDATAAKKMPGIVDVFTIQVYEPTQKLAMFDTRSFNEVIAVVGKTTWDVMNARKMLNV
VWENAPDTKEIMNNRETIVPGGLESTTKHYADMLAMDKKPGQIQRKDGEPEKAFEAAKHV
IERTYTAPFLAHNIMEPTNTFAHFQGNKVRFVAPIQGPDFIANTIATRLGIPKENIEINL
ARMGGGFGRRAYGHYMVEAALISKQANAPIKLVYSREDDVSGGIYRPTYQLTYRAAFDEN
KRLTAMHIKGGGIPESPLHANRFPAGALDNYMAESWSIPSNITVGAFRAPRSNFNAAAEQ
SFLDEIAEYMGKDPIAFRLELLQRAKDNPVGKNNDYDAARYMGVLELVRDKSGWGKPENA
NKKRGVSAYFCHNSYAAQVIDLRVKDGQVIVDHVTSAVDCGVVVNPEGAKNMAEGAAIDG
IGNALFGNLTFTEGRTNQKNFDTYRMIRHNEAPKKIDVHFVANETDPTGLGEPPFPPIFG
AMANALYKATGKRLYKQPFGNQIG
>A0A853ARX1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora hordei|TrEMBL
MPTHTFKVNGETVTVEADDNERLLWVLRDLLGIRGPKYGCGINVCKACTSHINGRAFNPC
AVPVGALSPDDEVTTIEGLPKTVGKDLHPMQEAWLEHDVAQCGYCQPGQIMAAVAKVNQA
RREGREIDDALLDEIRNVCRCGTYYRIRQAIKAGAEKM
>A0A0P1FXK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassobius autumnalis|TrEMBL
MNKPQSRLRKYSRRAFLIGATAIVGGVAFGTYALKRPHDNPLEADLAAGEAAINPFVKIT
SNKITLIAPHADKGQGVQSAQAALIAEELDVELDQVEISFGKPAAAYWNTAMAGELAPFM
SFDEGFAARTTRSALGAVTKVMGLQGTGGSSSMPDQYEKLRAAGAVARETLKAAAAKVSG
VPVAQLKTARGAVQLPDGTELAYTALAGAAADLDPVTEVTLRDPKDWRLIGKPMQRTDIV
AKSTGTLTYGIDLKIDGMVHAAAKVNPRQGGAMLGFDASAAKDMPGVQQVIEVQGPITER
AADGSLTTRSGPVGVAVIANNTWRAFQALEAIDIEWGKAPYPAEMDGHWQVLSDSFTEER
LDTDWRKDGDVDAALEGAEVLEAEYRAPYVAHAPLEPLSAIVRVDSDGAEIWAGHQMPRF
LQMKVAGALGLDDQEKVTFHNQFIGGSFGHRLEFENIMVATEIARQLPGVPVKLTYSREE
DFAHDFPRQIAMSRSRGAVKDGKVDAWDLQIAMPSVLASQGARLEQPVVGPDAQIISGAW
NMPFDIPNLRVRGYKAPALAPISSWRSVGASSNGFFAEGFFDELCHAAGADPMMERLRLV
NNPIHRKVLETVADMSNWGSELGPNRGRGIAMVESFGVPTAEVIEVTATEDGIKIDKAFV
VADVGQIIDPVNFENLMQGGVVWGLGHAMNCEITYSDGMAEQSNFDSAEAMRLYQCPEIF
IKGLENGDKIKGIGEPPVPPAPAALANAIFAATGTRLREMPFANYVDFV
>A0A3B0XWY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MKKNKQIINVSRRQFLIKGVSIGAGLTLGVHLQGCNDQSSVNSNAGPGLAGNENSSNKKS
NGAFNANAFVRIGTDNSVTVIMKHLEMGQGSYTGMATLIAEELDASWEQIKYEAAPADPK
IYNNLFWGPTQGTGGSTAIANAYTQMRKAGATARYMLVEAAAKKWQVDASEIIVKQGVVI
HDATKQSANFGKLAELASQQATPESVFLKDPEDFVFIGHQSPRKDSHEKTTGQAIYTQDI
KLPNMLTALVAHPPRFGATVESFDASQAKKIKGVSDVVQIPNGVAVLADNFWNAKKARDA
LIIEWNNDDAFKKSSDEILADYKNRAKKRGYIAKKNGNTSRAFKNAATVLEAAYEFPYLA
HAAMEPMNCVVHITDEGVEIWNGAQIQTLDQAAVAKLLGIKREQVKINMLYAGGSFGRRG
NPHSDYIVEAASIAKAIKKAGAG
>A0A3B0XSH9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MIKLTINNVEHTLDADSDMPLLWAIRDIINLTGTKFGCGISQCGACTVHIDGVATRSCVT
PISAVENKHITTIEGVTSKPAKAIQDAWQELEVAQCGYCQSGQIMQAIDLLSNNAQPNDD
DINAAMSGNICRCNTYARIRAAIHLAAKSLA
>A0A3B0RUD7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MRNLDFSNKSLADHKFAPARLVNGEGTVISFIINDTGVEVDAEPDTPLLWVIREHLKLTG
TKFGCGVGQCGACMVHINGKTRFSCLTPLSSVKGKEITTIEGLSPESDHPLQKAWVELEV
PQCGYCQSGQIMRAASLLKKNKKPSEEDIVKYMRTNLCRCGTYPAIVKAIQLAAKES
>A0A143PT99|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteitalea pratensis|TrEMBL
MSPVLSRRAFLGGTAAAGAFVLGTRLVPVSVFSQDALAQGPWEPGVYLAILPDGLVQIVA
HRSEMGTGIRTSLPLVVADELDADWARVTIVQALGDKKYGSQNTDGSCSIKDFYEPMRVA
GATARTMLEQAAAKTWNVLVGEVAARNHAVVHASSGRSLGFGALVATARTLPVPDAASLQ
FKKAESYRYIGKPIPSTDLDGIVKGQGIYGADVDRPGMVFASISRPPVLGSALTAVDDAA
ARKVAGVTDVVKLPEAKPPYMFKALGGVAVIGTSTWASMQGRNALKATWSASPNASFDSA
SFRTMLMDIVKTPGKVEREQGNVDATIGTGTTHEATYYTPMLAHAPMEPPMAVAEVRGGK
AEVWTCTQNPQAVQDTVGDALGIPPADVTCHVTLLGGGFGRKSKPDYAAEAALLARQVGK
PVKVVWTREDDLQFDYFHAPSAQYLKASVGTSGLPNAWLQRTAFPPIGSTFDEKERYGSF
QVGMGFTDIPYPIANLRVENNPAPSPVRIGWLRSVAHIHHAFAVQSFTDELAALAKADRV
EYLLKLIGQPRVIDLAAEGVKGFKGEPKHPFDTARLRRVIELVAEKSGWAKKPAAPGRAL
GIAAHYSFYSYIAAVVEVEVNARGQVTIPRVDIAVDAGTIVSPDRVVAQFEGAAVFGTSI
ALLSEITASGGKIDQSNFANYVLARQDNAPKQAHVHVVQSTAPPAGVGEPGVPVIAPAIA
NAIFAATGQRMRELPVRKVSGRA
>A0A7W6D549|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MKLNVNGSEHEIDVETEMPLLWALRDELDIRGPKFGCGIAQCGACTVFIDGEPVRSCSVT
VGEVSGAVTTIEGLAADGRLHPVQQAWIDEQVAQCGYCQAGQVMTAIALLEAIPDPTDAD
IDNAMSGNLCRCGTYPRIRAAIKRAASATAGA
>A0A7X0B462|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospirillum iridis|TrEMBL
MKLTVNGKSHEIDVEPEMPLLWVLRDELNLPGTKFGCGMAQCGACTVQVDGIAVRSCVTP
VGSVSGAVTTIEGLGTPAALHAVQKAWVELQVAQCGYCQSGQIMSAVALLREHPTPTDAD
IDEAMSGNLCRCGAYPRIRAAIHDAAKRIRGA
>G2ZT14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|blood disease bacterium R229|TrEMBL
MTKMPRIENASRRNFLNGAMGLTLAIYLPRVGAAAGPGVPAGAATPALQRFEPNAFVRIG
ADNVVTVISKHIEMGQGTYTGLATIVAEELDAAWSQVRVEGAPADAKRYNNVLFGPFQGT
GGSTSIANSWEQLRKAGATARAMLVSAAARQWNVPAEEIRIDDGVVSHTRGKHKATLGQL
ARGAAHLPVPTDVKLKDPKDFKLIGKHVPRKDSAEKVNGKARFTQDVHLPGMLTAMVAHA
PRFGAKVKSFNAAPAKAVPGVVEVVQIPTGVAVVAKDTWSARKGRDALQVEWDESAAFKL
SSDAIFARYHELAKTPGAVARKEGNADAVFAQPARVLRAAYDFPYLAHASMEPMNCVVQL
GKNACEIWNGEQFQSIDQAAVATLLGFKPEQVTLHMLYAGGSFGRRASKDADYVLEAVNI
AKAIDGRAPIKLVWTREDDMRGGYYRPAFHHTLEAALDTLGRPVGWRHRLVGQSILANTV
FGSMVKNGIDPVSVEGAANLPYEIPALHVDLHTPNDIPVPTHWWRSVGSTHTAYSTETFI
DELAAAAGQDPVAYRLALLGKHPRHAGVLKLAAEKAGWAQPLTQDASGAKRARGVAVHES
FGTFVAEVAEVTVKPDGSFSVDRVVCAVDCGIVVNPDVVRAQVEGGVGFALSAALHGAIT
LKDGVVEQSNFHDYAPIRINEMPKVEVHIVPSAEKPTGIGEPGVPPLAPAVANAIAAATG
KRVRSLPIRAEALKA
>S5YSV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paracoccus aminophilus JCM 7686|TrEMBL
MIEFTVNGQKVSTDADPDTPLLWVIRDEIGLTGTKFGCGIGMCGACTVHVGGRATRACVT
EVSEVAGAVVTTIEGLDPKGDHPVQQAWRHLRVPQCGYCQSGQIMQAAALLKDMPHPSDD
DIDAVMTGNLCRCMTYNRIRAAVREAAGAMRGETANG
>A0A841ARG7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis umgeniensis|TrEMBL
MASPTTGTQEQDPGGLGRRRFLSFLVAAPTLTIATKIGIDAVAPEEAEAVIPTLPGPAEI
LDLGDVLILSNAPTAGLLVLEVREDGRVRLELPRTEVGQGITTANAMLVAEEMDLPLDRV
DVVLSDARPELLFNQLTGGSNTMRSLYTPVRTAAAAARARLVATAARQWGAKADRLSTRD
GAVIAPDGRRMGYGALSKPAARADLGKLTVTPKAESAHKLVGTPQSRKDARAMVTGQLKY
TLDLDVPGAKPAMVRRPPTINGTVKKVNNEAAVRAMPGIIDIAVIKTGVAVLAETFGQAL
DGKNALDVTWNGGTVDGENNATIKKKLRAAALPFVVPPLLTQYVDGEFDFAFASHAPLET
NSAVADVREDGATIWSGMKVPILAKQNIAAELGLPVNKVTVHVQQAGGSFGRRLFSDGAI
EAARISKAMKRPVRLMWSRIDDMRHGRARAASHHKIRATFALGQVLTFEHRVASVETDWG
HGLGEVLTAFAAELPVGGNLSFAQTVFLLTVKSPYNFGVTTQLLNEVPVDFHTGAWRSVY
SSSTRGAEEIMVDEIAAKLGKDPVAFRREFIKNERQRAVLDKVAELGEWGKKMPKGFAQG
VAVHGEYKSYTACLVEMDARDPKNPRVTKATIAVDVGKPINPRGIEAQMLGGLTDGISTT
LTAGLHIDKGLPLEGSYSQFHYARQKNSPKDVKVFVMPETGEIGGAGELGVPAPVGAIAN
AYARATGIKPRSFPINFPIDFDPFPR
>A0A7W6F9I0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium brachythecii|TrEMBL
MPSIEINGRTRDFDVADDTPLLWVLRDVAGLTGTKFGCGVALCGCCTVHLDGEPIRSCVT
AIGDVAGRKITTIEAIGETEAGAKIQKAWLDLEVVQCGYCQSGQIMSAAALLAGNPKPSD
GDIDTAMSGNICRCGTYPRIRAAIKHAATA
>A0A7W6WUL6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MNFIDNPRKLRGFEKNIRVEKVSRRSILKGLGVTGGFVLAAPVMSRQALAYETGAGKMPH
GVVVDPRVFVSVAPDGIVTIVGHRSEMGTGVRTSLPLIVAEEMEADWSRVKVQQAHGDEV
KFGNQDTDGSRSTRHYLIPMRQIGASARTMLEQAAAKRWGVPATEVKAVNHEIVHSASGR
KLGFGELAADAAKESVPSIEGLKLKDPKDFRYLGKGQIGIVDLHDITTGKARYGADVRLP
GMKYAVIARPPVTGGKLVKFEPDEALKVPGVEKVMQVRGWPWPSKFQPLGGVAVIARNTG
AAIKGRDALKLTWDDGPNGKYESVAYRKEIEEASRKPGLVLRQEGDADAALKGADKVIVG
EYYIPHLAHVSMEPPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLGIPEANVTVNVTLL
GGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDIHNGFLHTVSVERIEAGLDKSGKV
IAWRHRSVAPSIASTFAAGTVHQAPFEIGMGLVDMPFEIANISCENPEAAAHTRIGWFRS
VSNIPRAFAVQSMVGEIAQATGRDQKQMLLELIGSPRIVKPAVKDLWNYGEPYDSYPIDT
ARLRKVVELVAEKGEWGRQVPKGHGLGIAVHRSFVSYIATIVEVAVDEKGKLTVPRVDTA
IDCGTYVNPERIASQIEGAAIMGLSIAKYGEITFKDGKVQQKNYDDFQVIRMDESPVVTN
VYIVPPGPDTPPSGVGEPGVPPFAPALINAIFAATGKRIRSLPIGKQLEA
>A0A0S3PWD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variibacter gotjawalensis|TrEMBL
MVDVTINGQARKFDGDPSMPLLWFIRDELGLTGTKFGCGIAACGACTVHVNGEAVRSCGI
VMSDIAGKQVTTIEGLDAKGEHPVQVAWRQLGVPQCGYCQAGQIMQAAAFLKTNKSPNDE
QIVEAMSGNLCRCGCYQRIQAAVRAAAKGA
>A0A508SXH7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MAFQININGTSHSVDADGDTPLLWVLRDVLGMTGTKFGCGMALCGACTVHLDDTAVRSCI
TTIDSIGDSKITTIEAVGKTPAGKKIQDAWLAHEVPQCGYCQSGQIMSASALLASKPKPT
DADIDDAMAGNICRCGTYVRIREAIKQAAQSGG
>A0A7U3ZLR9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MAKYNLKINGKIRPVDLDPSTPILWVLRDHLNLPGTKFGCGMAQCGACTVHLDGKAVRSC
VLPVSAIGKQEITTIEGLSANGDHPVQKAWLEHDVAQCGYCQSGQIMSAVALLKSNPHPS
DADIEAGMSGNICRCGTYLRIKEAIKTASKV
>A0A7W7KQH4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas nitritireducens|TrEMBL
MITVNLNGKDHELDAPGEMPLLWAIRDVAGLTGTKYGCGMALCGACTVHIDGQPTRSCVT
PLAAVAGKKITTIEAVAEQAAGKAVQDAWRKLDVVQCGYCQSGQIMSATALLASNKQPSD
ADIDAAMSGNICRCATYARIRAAIHDAAQTLA
>A0A839XP92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella sediminis|TrEMBL
MTTTDGPRTVNRRKFIGYLLGGATVVAAADLGMFGRGATADAGELPTLPQPAEIADLSDL
LTLAAAPTSQLITVTINDDGTASFELPRAEVGQGITTAAAMLIAEELDLPLDKVHVTLAP
ARPELLYNQITGGSNTIHAMYTPIRVAAAVAKGALLQAAATVLGDSANKLTSHLGHIVAP
DGRRVDYGRLSALAAKEQPEAVEVQLKDEGSHGVVGTPVNRIDALDAVTGTKRFATDLDV
TDALPTMVCRAPTLNGTPNAVHNADEVRDMPGVTHVATVPTGVAVRASTFGQCIDAVRAL
DVSWNDGPVAGMSDEDALAGVRAAEGPVPALPAGETVSGDFTFWFRSNSAMDTNSAVADV
REGRAEIWASLKNPNVAQGRIAEALGIPLNNVTVHVVQGGGSFGRRLFDEPAIEAARISH
AMGVPVKLMWHRADDARVGRTHPLATSRIRACYSGDTVLGFQQAHTSIETDFRHGLGDII
TAKAADLPAGLGNLPFAQVIFHLTTILPYDFGAVGQSLVETDTRFNTSSMRNIYSPDVRT
ANELIVDQLAQRMGTDPLEFRLSHLRNGRLRTALETAAEKAEWGKELPEGMAQGIGVHVE
YKGVTACIMEIDCRPETVNRKVRNAVTGPRVTKATMVIDCGRAINPRGVEAQMQGCVNDG
IAMTLTSSLHLRDGHFQEASWDNYFYTRQWNTPPELDVVVLESTEPPGGVGEAGVAASAA
AAACAYARATGTMPTEFPINHQTLSFDPKPYTPPVPQSPTDGLDHTY
>A0A218PNT0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hyphomicrobium sp. GJ21|TrEMBL
MIGFKVNGKEVSVDVPDDMPVLWVLRDVLGMTGTKFGCGIGQCGACTVHVDGEPRRGCLT
QASDVAGHDVTTIEGIGATPAGKAVQAAWLNLEVVQCGYCQSGQIMSASALIKDKPTPSD
SDIDEAMTGNICRCGTYLRIRDAIKEAAKAIAAK
>A0A6S7FBL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter insolitus|TrEMBL
MMLTAQLSRRGFLQGGLGALTLAITAKGLITTVWAAEPATQKYGADSMPGGTVDDPLVFV
SIATDGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWDRVKVIQAQADEVRYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPLAEVKAVQHEVLHQASGRRLAYGELAAD
AARQPVPTGDALKLKDRSEFRYIGKDQVRLVDLEAIGKGQASYGMDMRLPGMVYAVVARP
PVVGGKLRRFDSARALAVPGVLKVLEIPPMQGAPAFQPLGGVAVVARNTWAARQGRDALD
IEWDDGPNGSYDSVAYHQALESAARKPGKAIRNQGDVAQVWAKAPEAGRLAAEYYVPHLA
HASMEPPVATVQIKGGNAEVWTSIQNPVAARDAVAARLKLDPAKVKVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPEGTPVKLVWTREDDIHHDYLHTVSVERLEAVLDTSGQVQSWLHR
SAAPTIASLFSEGAKGQQMFESAMSAINMPYRIPHVRVETAEVEAHARIGWFRSVANIPH
AFAAQCFIAELAERAGKDPKDFALDLIGPARRIDPGTLADTWNYSESPERYPYDTGRLRG
VIEAACKGAEWGRTLPKGHGLGLAFCYSFMSYTATVVEVAVDEKGEVRIVAVDMAMDCGP
QINPERIRAQMEGGAIMGLSLALTSEITFEKGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHTLPPGGVGEPPVPPVAPALCNAIFAATGKRIRNLPVRRVA
>A0A1Q8JXJ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae707_Ps1|TrEMBL
MSGHTFVLNGERVTVEIADDVGLLWVLRDVLGVTGAKYGCGINVCKACTSHVNGNAFNPC
AAPIGAAQGLTRSPRSRV
>S7WV11|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cyclobacterium qasimii M12-11B|TrEMBL
MANYTLTINGSQHQVEASEDMPLLWVIRDLLDMKGTKFGCGQGLCGACTVLLGDTALRSC
SLRVSEVGEQGITTIEGLSQNGDHPLQKAWTAHIVPQCGYCQAGQIMNAAGLLKRNPSPS
EDEIENAMAGNLCRCGTYNRIKEAILTAST
>A0A5P9PML8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. YIM 10|TrEMBL
MLPDDVKTGHRTPPSPGAVDRRKFLTYVLAAPTLTVAARVGLAATSAPAAEAAVPTPPQL
LGEVISVQDLIDVLALPTAGRLFVIEIGEDGTVTVPLPRTEVGQGLTTAVPMIIADELDV
PLSSIRMPLADARPDLLFAQITGGSTGLSSVYGPARMAAASARARLVATAAHRWDVSADR
LTTRDGVVHAPDGRQATYGSLAAAAVTAQLPDLGVQLKPESALRLVGGRVGRLDARNIVT
GKQVYTQDLNVAGAKPCVLRRPPTINGGVGAVHNADAVRAMPGVLDIATIPTGIAVLAET
FALALAAANALEVDWKPGTIDAESDETIQRKLRAAIGPLGDPPVSLPTLGLGKLEMEFDF
AFLTHAPLETNSAVADVRPDRAEIWSGVQVPTSAQTEIAAALGLPQSAVTVHVAHSGGSF
GRRLFYDAALEAALVSRAMGRPVKLIWHRTDDIRHGRVHPAKHHKVRAYYALGNVLAYQH
WCAAVDTSLAHGFGEAMTIALTKTELGNKVVSQAMFDAMIGCPYNFGVVTQQLHEVSVPM
NTGSWRSVYSLNVRGVEEIVTDELSRRFRSDPLSFRREFAKNSRQRAVLDRVAAEGEWGR
PLPAGVAQGLALHDEMRGVMACLVELDARDRSHPRVTRATMVVDVGKPVNVSGIEAQALG
GLTDGISVALRGGLHLRDGRFLEGSYHNFHYARQKNSPPEVKIVVLPATTGKPGGMGEFA
VPVAFAAVVNAYRRATGIMPTSFPIDSGVDFEPYPPSVMPMPPMRPLPLP
>A0A8H2NTD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVAGQNVSTIDNLHADPIGKVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7VQ14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGHKFAYAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMPGFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFEVAPSAIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGASV
KSFEGAEALAVPGVHKVLQVPTGVAVIADHYWAAKLGRDALKIDWDLGPHADLSSEKLLA
SFRKLAATQGTSASQAGDAKGSFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAEKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMP
VKTVWSREDDIRGGYYRSMFLHQAKIGLGADGLPSSWQHVLVGQSIMTGTLMEATMVKNG
IDPTSVEGVSDSPYVKGLANHQVDLHSPQTGINVLWLRSVGHSHTGFVMESLIDEMATAA
GKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLTIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLKDGAVVQSNYHD
YQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>A0A0M7A4Y1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii|TrEMBL
MTKANEALNISRRGFVKMAAGLSFAIGLGGVSAVRATASTETTLDVNHWLTIRPDGTISI
VFPSTEMGQSSYSTLPQILAEELDANWDDVVIEQLNADDRRFGNPLFGNVLYTAGSTGVQ
AYFEPMRRAGAQARDVLLQIAARELGVSKGELRTEPSAVVAPDGTRLGYGELVARGAAGT
SVPEADAVTLKERSEFRIIGHDVPRRDVVAKSTGTAVFAIDVALPNIAYATVLRAPVEGE
RPLSINDAKARAVPGVLDVVALPDGVSVVAESLWSALGARSMLEVTWSEDAPARAFNSEE
TLRLYAEAAEDPEAEQAVWAEKGNAPAAIAAANQTYSQLYLSDYAYHAQIEPMAAVASVD
ADGQGAEVWAGTQTQSWTTRTVMDVLGIEQDKVRLNMMTMGGSFGRRTALTQDYVRDAVL
SSKAVGRPVKVIWTREDDVKNGTFRPAAAQRLEAGLTADGKLDGWHHKVATPTVIGFFNP
VRWDAVKPNDVISMRGAESKFYGIKDFRADHIITRRQARLAPYRGIGAAYTSFAAEAFMD
ELAGQAGRDPLDFRMDLVADNPRGRHLLEKVAEMSNWSSQDGRALGLSFAGYSSSMAAGV
AEIEVDQSTGDIAVKHFWTAVDAGLIVSPDNAHNQIEGGIIFGISMALREKIDIENGEVV
QNNYWDYEIARANQIPPIEIYMADVDAPPVGVGEVGTPMVSAAIANAFHRATGRRLRHMP
FTPDRVSALLQS
>A0A5E7GH49|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MQKLTINNQEHELDVPDDMPLLWVLRDVMGLTGTKYGCGIAQCGVCTVHLDGHAVRSCVL
PVSAVAGRKVTTIEAVGEQAIGQAVQKAWLEHEVVQCGYCQSGQIMSAVALLQEHPKADD
EQIVSAMSGNLCRCATYTRIRSAIKSVSQA
>A0A5E7Q2T5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSIKPVSRRGFLKGSALLGGGLVVAFVIPGAHRFASGAENQGKVFAPNAFVRIGNDDSI
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAADYGLAGFGGMQITGGSTS
TWMEFDRYRQAGATARLMLIEAAAKRFNVAPSGIRTESGVVIAGDRRATYGELADDAGKL
PMPDPASIKLKEAKDWKLIGKPTKRLDTPEKITGQAKFGMDVQFEGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVLQVPTGVAVIADHYWAAKLGRDALSVDWDPGPNSGLDSQAL
LENFRKLATTPGVSVSKAGDTDGTLGKAVKTLDVEYSVPYLAHAPMEPLNCTVSITQNKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
APVKTVWSREDDIRGGYYRSAFLHHARIGLDAAGQPIAWKHVLVGQSIMAGTSLEATMVK
DGVDKTSVEGVADSPYLAGLAHHQVDLHSPKTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPLDYRRTLLKDHPRHLGVLNLAVEKAGWKTPLPNGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKDGQVEQSNY
HDYQVLRLNEMPLVEVHIVPSSEKPGGIGEAGVPPVAPAVANAVFALTGQRLRELPLQLS
GV
>A0A8B4I926|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MQQAFIDEQAAQCGYCLNGMIMTAKALLDRNPNPSETEVRNELSGNLCRCGTHIEILRAV
LRAAHLLTVDGRP
>A0A5E7H2L5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSIKPVSRRGFLKGSALLGGGLVVAFVIPGAHRFASGAENQGKVFAPNAFVRIGNDDSI
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAADYGLAGFGGMQITGGSTS
TWMEFDRYRQAGATARLMLIEAAAKRFNVAPSGIHTESGVVIAGDRRATYGELADDAGKL
PMPDPASIKLKEAKDWKLIGKPTKRLDTPEKITGQAKFGMDVQFEGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVLQVPTGVAVIADHYWAAKLGRDALSVDWDPGPNSGLDSQAL
LENFRKLATTPGVSVSKAGDTDGTLGKAVKTVDVEYSVPYLAHAPMEPLNCTVRITQNKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
APVKTVWSREDDIRGGYYRSAFLHHARIGLDAAGQPIAWKHVLVGQSIMAGTSLEATMVK
DGVDKTSVEGVADSPYLAGLAHHQVDLHSPKTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVDYRRTLLKDHPRHLGVLNLAVEKAGWKAPLPDGHALGVAVHESFGSYVAQVAE
VSHDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKNGQVEQSNY
HDYQVLRLNEMPLVEVHIVPSSKKPGGIGEVGVPPVAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E7TGP8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVSTIDNLHADPIGKVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7SKV4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIESDEVGKRVVSTWVDLQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHAAMHELAGKGEA
>A0A448DUN2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIAFTVNGERRELEETSSSTPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
MPAAAVAGHSITTIEGVSATQSHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
ASIRTAMSGNICRCGTYGRINKAIKRAANAPKEA
>A0A0U5ERJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter senegalensis|TrEMBL
MPSLFVSKADNALNPLLRRHFLGGGIALAFAGLPAARSKVALAQTSQNVHSPSDITLGGV
VRIGSDNKISLIVPNIEMGQGIYTTEAIIIAEELEVDPKDITVLPALPQDVSDVAPKFLK
SLSTGGSRSVRNGWVPLRQAGATVRLMLLTAAAARWNIPQHLLAAENGYIKDHTGQHCAQ
YGDFAVDAARQNIPQNVPLKSPSDWKLIGKSFPRVDIPAKTNGTAVFGIDVRVPEMAIGA
VMGAPVIGATLDTLDDTLCRTIPGVLNVLKTSTAVAVIARNYWTAKKGLAALKIKWVEGK
NSSLSSEDIRRKIRDASLSVPEIIARNDKPKNTSAESGKKLEATYELPFLSHAPMEPANV
TLHVRAERCDVWMGTQVPTRARAAVAKITGLPPEKVAIHNHMIGGSFGRRLATDFLEQAT
HFACQVSHPVKFIWSREEDIRQDLFRPAYYDRISATLGQNGQPLSWQHHVSGPSVVDRFA
PGGLPVGKLDTDAVAGAVDTP
>A0A654BFN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. T1|TrEMBL
MGIGLVVAWGLWPRDYAPTLVADPGESAFGAWLKIGSDGHVTVAVPQAEQGQGVYTALAQ
IVADELGADWRTVGVEPAPLNLLYANPVGLNALFEGMPGVVPAAVAGPAPMLTAGSSSVR
MFEAACRSAGAAARVLLCKAAARRWDADWADCRTEAGFVVQGTRRIRFAALAEDAARETL
PDEPGIGGPGAGALAGRSVPRIDTPAKVDGSANFTGDVRLPDMVHAAIRQGPVGDSRLIG
VDRAAADRVRGVLQVVETPRWVAAVATTGWAAQQALSAMAPRFATRGPVIDSGTIVAALD
AAFEAPGATMAQTGEIGTLLDGAGVVTAAYRVAPAVHAAIETRSATAAYRDGILELWLQT
QAPGPARAAAARAAGIDEAQVVIHPMPVGGSFGAALEHDAAAQAAVLAVRLKRPVSLVWS
RAEDLMHDRYRPAAAARLAARLDARGRILAWRTAIAAPATGAEIAARVLPGIASRAATAL
TRGDPHAVGGALPAYAIPAVAVVHHAAEIGVPTGALRGGAHGYTAFFTETFVDELARIAA
TEPMSYRIGMLGGGARLARCLSTAASLGGWNGGVPGSGQGIAAHAFRGSFIAVLAEAHLG
ADRRPVVERLVAAVDCGVQINPDLVRQQIEGGLIFGLATALGAATGFTRNLADARGFGDL
HLPRLADTPDITVELIRSDEAPGGVGELGVPAVAPAIANAIFSATGFRLRDLPLRPST
>A0A7Z0VIV3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Thiodiazotropha endolucinida|TrEMBL
MIQLTINGSKQSLDIDPGMPLLWALRDHMGLTGTKFGCGIAQCGSCTIHLDGEPVRSCIT
PASEAIGKQITTIEGLKSPSGKAVQAAWRELEVVQCGYCQSGQIMSAAALLERKSKPTDA
EIDAAMQGNLCRCATYVRIRAAIKAAANKSV
>A0A1W6KA45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter salarius|TrEMBL
MSQSDDTLLLANVSRRGLLKGLAGASALLLAARWDIGLANEQAQFGAGAMPGGWVDNPNV
FIHIDANGLVTIVNNRAEMGQGIRTSLVMVAADELGADWDRVRAEQADGDQDKFGNQNTD
GSRSMRHWYDPMRRAAAAARLMLEQAAANQWGVSVDQVRADIHKVVHPATGRELGFGQLA
EAARELDVPGRDGLVLKSDSELRFIGKESGLINGELKSTHPKAIDGEDIVTGKAIFGADV
DLENTLYAVVARPPVYGATVKSVDDSEALKVRGVKKTVRIDGTGQPAAFNPLGGVAVVAT
NTWAAMEGRRALKIEWDNTPAGNNADYTSDTYRESLEKAAQSPGKVIRQSGDVEAALKEA
NKRVSATYYMPHMAQAPMEPPVAVVRVNGGKAEAWAPVQNPRATREGIAGLLEIDLENVT
VHQTLLGGGFGRKSKPDFVIEAAQVAKAFEGQPIKLQWSREDDIQHAYFHAVSVDHLEAG
LDGNGKATSWRHRTLSPSIASLFAPDPKHKAGFELGMGFNTMPFSIPAIRLENPPAPAHV
RIGWFRSVYNLPHAWAIQSFAHEMAVAAGKDHRDYVLDLLGPGREVHNLTVGDGWNYGED
PEMYPIDVGRMRRVIERATEEAGWGKERAKGRGLGLAFHHSFVSYTAVVFDVEVDDGGQV
TIHRADIAFDCGPQANPERIRSQMEGSCVMGIGIALQNEVTFQDGVAQQSNFDRYLLPRM
PNAPKVVRVHLIDNPDDAMGGVGEPGLPPVAPALCNAIYAATGKRIRRLPVGDQLSA
>A0A369QQA9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Adhaeribacter pallidiroseus|TrEMBL
METAKKTINRRDFLKASALAGGGMMLSFSWLAGCKPTTEEVSKLPKAWFELNSYIKIGDN
GLVTLFSPNPEFGSNVKTSMPMMLAEELDVDWKNVTVEQADFFPERYDRQFTGGSLAMQM
AWKPLRTAGATARHLLINAAAQTWKVPASEITTKDGVLHHKGSGKEGGYGEFASQAAKLK
VPEEVPLKKVGDFKIIGNSKRNVEGMNIVTGKPLFTLDYKQEGMLIAMMAHPPAFGLKVK
SVEDKAVKSMPGIKDVFVIKTLADDYERNGFDTTSFTELVVVVGNSTWEVMNAKKALKVE
WEKISDSTVTIAGFGGNKQMVKIPAGLESTEKHQVKMAEMMKKPGKELRKDGDPAGVFKT
AKKVIERTYTAPFLAHNAMEPVNCFAHVTKDKAEIVAPIQAPELISQTLAARLGLPKEKI
HIKLARMGGGFGQRAYGHHLVEAAVISQKLQAPVKLVYTREDDMTYGIYRPMYTATYKAA
LDDKNNLIAYQVKAGGIPESPLGFAQNRFPAGAVDHYLAEEWMLDSNITIGAFRAPRSNF
LGAVEQSFLDEVAELAEKDPIEFRLELLDRAKKKPVGKQNDYDAERYAGVLKLVRDKSNW
KQASKDVHRGISAYFCHNTYVAQVIDLTMQENKPVVEKVYAAVDCGVVVNPDAATNMSEG
GIIDGIGNALYGEMTFQEGVPQKSNFDKYRMIRHSEAPKAIEVHFVKSEADPTGLGEPLF
PPIFAALANALYKATGQREYTQPFLQGNKQLV
>A0A7Y9RGY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. IAR9|TrEMBL
MANLTINGKTFTLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHIEGVATRSCGV
SVSEAEGKKITTIEGLASGDALHKVQEAWIAQDVPQCGYCQSGMIMAVAALLSEKPKPTD
ADIDEAITNICRCGTFQQVREAIHTIASA
>A0A7Z0B2L3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MQFELNGRPFSFDGDAQTPLLWVIREHAMLCGTKYGCGIGACGACTVHLEGDAVRSCVLP
VSAVAGKSIRTIEALSPDGTHPVQRAWVAKDVPQCGYCQSGMVMAAAALLAQTPKPTDAQ
IDQAITNLCRCATYQRIREAIHVAAEH
>A0A7Y9UFE1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. IAR9|TrEMBL
MPTLTINGRSLSVDAANDTPLLWAIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
MLSDVAGKKITTIEGLSAKGDHPLQKAWVAEQVPQCGYCQSGQIMQAASLLSKNPNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAASEMRTASATSTERRPT
>A0A839VN29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Herbaspirillum sp. Sphag64|TrEMBL
MTTSFHLNGKQVTVQAEADTPLLWVIRDELGLTGTKFGCGMALCGACTVHLDGTPIRSCQ
TPVSAAAGKKVATVESLSKDNSHPLQKAWIAHDVPQCGYCQSGQLMSAAALLRTNKNPSD
ADIANAMSGNICRCGTYNRIRAAIKDAAAEMRKA
>A0A7W9KMN4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kutzneria kofuensis|TrEMBL
MSSHTFVLNGERVTVEVADDVRLLWVLRDLLGVTGPKYGCGLNVCKACTSHINGKAFNPC
SVPVSAIDADDEITTIEGLPGTVGKDLHPMQEAWLEQDVAQCGYCQPGQIMSAVALVHKV
RAEGRAITDADLDQIRNICRCGTYSRIRTAIKSGAANM
>A0A645C838|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bioreactor metagenome|TrEMBL
MDVKVGGMLIGTVAACPVRGGRLKPFDDKPALAVKGVHKVVPLAGSAVAVLGESYWPARQ
GLARLQLDWQLPEGPLVDSKAMLAQLRGAAAQTDTVAKRTGDPEAALREAAQRVEAEYEV
PYLAHATLEPINATADVRADRAEIWGPTQVCGEIAERLAPHLGLPAERIAVHSTFVGGGF
GRREEFDVFIQAALASQAARRPVKLIWSREEDIQQDFYRPAAAARFAAVLGEGGSVQALE
ARLACSSIYIRNFPDRVKNGVDPKSVEGVVDVPYALPHFGVRYAMVNSAIPAGFWRGVGY
TQNCFFFESFIDELAHQARRNPLDFRLALLKDQPRHAGLLRRLASRAGWGQAPSPSGGDR
HLGLALSEAWGSICGTAVELSVKDKRITIHRVVCVVDCGTVINPATVQRQLEGATIWGLA
AAAFGEISIEQGKVLQSNFHDYPMLHLAQTPPIETELIVIGRVPLNIRTNETELCRPRQS
APT
>X5MN24|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Phaeomarinobacter ectocarpi|TrEMBL
MINVTINGKPEVLDVDPDMPILWVVREDLEMTGTKFGCGIAFCGACTVHLDGVPIRSCST
PISAAEGLEITTIEGLPDTDGKLAKVQQAWIDAQVPQCGYCQSGQLMSAAALLRDNPDPT
DEDIDAAMSGNICRCGTYPRIRAAIKAAARA
>F3BGC1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas distincta|TrEMBL
MVESHASEDTPLLWVIRDEIGLKGTKFGCGIAMCGACTVHLDGQATRSCVLPIGAIAGKN
ITTIEGLNNEHPLQKAWVEEQVPQCGYCQSGQIMQAATLLAANPSPSDEEIVSHMNGNYC
RCMAYKRIKTAIQRAADESQSVVNIFDPNAQDA
>A0A7W5LKH6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK313|TrEMBL
MADTTSNFAQSDAYLSALIHEVRSTPTANASLAIGRRGFFKLAGAGAAGLVLGFYLGDPA
FAAETADSKEQVMNAFIRIASDNTITIYSKCPEIGQGIKTSFGVIIADELDADWNHVVME
QADINPKVYGSQGAGGSTSIPRAWDQLRQAGAGAKAMLIAAAAQQWAVDPSQITAQDSVL
THAASGRSATYGSLAAAAAKMPVPDPKSLKLKTRAEYRLIGKAYRGVDDPKVVTGQPLFG
IDVQRPGMVYANFTKCPAAGGKVRSFNVDEIKAQRGVLDAFAVDGTGMAVEVMPGVAVIA
KDTWSAFQAKDKLKVDWDLSEASTDSTSQFSAQAKKLANSFPEKPDDNVGDVDKSFANAN
KTVEAYYEYPFAAHVPLEPMNTTAHWHDGVMELWVPTQQPDRGLPLIAKVAGIPQEKVVM
HQTRVGGGFGRRLVNDYACEAAAIALKVNAPVKLQWTREDDFGHDFYRPAGYHQFKGAIA
KDGSLDAWQEHFITFTADGKKEASGANLTDNLRYSIKAPNLRRGKTMFPLKIPTGAWRAP
GDNAQVFAAQSFMHELSLASGRDHVQFLLDAVNRDVPELAPKDQSVNFSPKRASDVIRMC
AEKAGWGKTLPKGSGLGLAWCYSHAGHVAQAVELSVDANKQIKIDRILVVLDVGPIIDMA
GSEAQAQGASTDALSTAMGLKINIENGRIQEQNYNAYPILRLPFAPMTIDAYFIQSDNPP
TGMGEPAFPALAPALGNAIFAATGERVRRLPLRDLGYSLAI
>A0A7W7A357|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas yabuuchiae|TrEMBL
MSSFTVNNQPVRYRLPPDTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGRAVRSCQV
PIGRIEGSVVTTIEGLSRDRSHPVQQAFLAANVSQCGYCIPGMVMAAAALIRKNPDPSEE
LIRAQITNLCRCGVYPRLVEAIQRAARAARGEETIPAAPMPGTDPGDAARAVPALVPGAM
RDE
>A0A6M4GYD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MTTLTVSRRTFIQGSAATGAALTLEFAIPGSAFAQKAGAAPSEVTAWILIYPDDKVTIRV
ARSEMGQGSLTGLVQLVVEELECDWSKVGWEYASPNEHVKRKRVWGSMSTGGSAGVRTSQ
EYLRKAGASAREMLVGAAAEQWKVSAADCTVTNGVITHGPSKRKLSYGKVAAAAAKRTPP
DEKTVKLKDPKDWKIAGKDIARLDIPDKVLGKPVFGVDVMLPGMLHASIAQSPVFLGKVK
SVDDSAVMKMRGVKGVVKGSDFVAVVADNWWRANEAVKALKIEWDEGANGKVSDDSIKAM
LKAGLDEKGLPTARATGDTPAALAAAVKVVEAEYYSPYLSHATMEPMTGTAWFKDDGMLH
VWTSTQNGEASIAAASEASGLPLEQCEVHKMMLGGGFGRRGAPQDYVKQCVIIAKEFKGK
PVKMIWSREEDMQHGFYRPVSLVRMKAALDKDGNVTAFQSTIACPSILALLRPEGIQKGI
DFTAVRTFSDMTYTIPNQLCEYAQKNPHVPVGFWRAPGLQNSFYRECFIDEVAAAAGKDP
LAFRLAMLKPDDKNRLVLEACAKAANWGTPLPAGVFRGIAQSDGFGSFTAMAAEVSVNPA
GEIKVHRVVFAIDSGYVVNPDACRAQAEGNVIYCIGQFYQAHHIKDGRVQESNFHDFPLP
KMPEMPKVETVFVPTGGFWGGHGEPGALNVAPAIMNAVFAATGKRIRTLPFTADELKKV
>A0A423MU45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRASEIG
>A0A1X1PFC2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia puraquae|TrEMBL
MITLTVNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRSCIT
PVAAASGKRVTTIEGLSTDLTHPLQQAWQELNVAQCGYCQSGQIMQAASLLKTNPHPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAVRRGGAA
>B1FTW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MSTSFVLNGKNVTLDADPTTPLLWAIRENAGLHGTKFGCGMAQCGACTVHLEGEATRSCV
LPLAAVAGKRITTIEGIESRPAKAIQAAWVKLQVPQCGYCQSGQIMSATALLERNATPTD
ADIDAAMNGNLCRCATYARIRAAIHEAAATLKA
>A0A346B8Y4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinilytica|TrEMBL
MSQGLLDSQNRAQPSKGGKGAISRRTFLKFGVTVGAATGGGLLLGFSMPAVSQDQKAGKS
VIGGDADEAPHSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVPLDS
VTLDHAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRRAGAAARTVLISTAAQQWQVDPA
SCHAEAGQVRHAASNRSIGYGQLVNAAAGLPAPQNVKLKDPKDFKVIGTAVKRLDSPEKV
DGTAMFGLDVRVPGMVYAAIANCPVFGGTLASVDDTHAKKIPGVRQVVKVDNAVAVIGDH
TWAAKRGLQALDIKWNEGAGAKIGMKQIVDDLANASQRNGAVARKDGDVNNAFANAKTRV
DAVYQQPFLAHATMEPINCTVHVRPDGCDIWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LLGGGFGRRLEFDMVTQAVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDRISAGLDANG
KPVAWQHRIVGSSILARFAPPAFRNGLDPDAVEVASDLPYDLPNQLVDYVRQEPHAVPTA
FWRGVGPTRGTFVVESFIDELAAQAKVDPVKYRQDLLGKTPRALNVLNTATRAANWGSAV
PKGQGRGVSVMHAFGSFFSIVVDVAVDQGEVAVKRVVCAVDCGMVVNPNTIEAQVQGGIV
FGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIEVHIVKSSEAPGGIGEPGTAALA
PALTNAIYAATGKRLRQLPVGSQLQTA
>A0A346BHR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinilytica|TrEMBL
MTTDLDLKDSVRPSRRTFLKAAGAVAAVGLTIGFEWAGTGRRALAATMPDATFAPNAFLR
VAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWQDVRVESAPADAKRYANLAFGTIQ
GTGGSSAMANSWMQLRDAGAKARAMLVSAAAAQWKVPASELTTRDGSVHHAATNRTATYG
SLASAAARLPVPDKVTLKSPKDFRLIGHQLPRVDVPPKTDGTAQFTLDVTFPGMLVALLQ
RPPLFGATVKSFDASAAKAVPGVVSVVQVPAGVAVVAKGFWAAKQGRDALKVEWDDSKAE
KRSSDAIMAEYRQLAEQPGASARKDGDATQALAGAAKKISATYTFPYLAHAPMEPLDAVV
KLTADSCEIWAGDQFQTVDQGNAAHTAGLDPQQVKIHTLYAGGSFGRRANTRSDYIVEAV
SIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAGLSADGKLVGWRHRIVGQSILA
GTPFASVMVKDGIDGTSVEGAANVAYAIPNLSVELTTTQTGVPVLWWRVVGSSHTAFAVE
AFIDEAAHAAGKDPFVFRRDLLAHEPRMRAVLELAAQKAGWDPARPLPKGRGRGIAVAEA
FKTFVAQVAEVSVDKDGNVKVERVVCAVDCGTPINPDVIAAQMEGGVGFGLGAALHGAIT
LKDGKVEQNNFDGYQVLRIAEMPKVEVHIVQSGEAPTGVGEPGVAPVGPAVANAIFAATG
RRIQSLPFPAASEKTA
>A0A0A1DMW4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides simplex|TrEMBL
MGNSSARPPAPSGSGTGRARHLSRRSFVGYVMGGTGLVVAADLALGSAPAHALPIPSVPQ
VPEVYDLNDFLTHCALPTSQLIAIHVDEQGDAHFALPRMEVGQGITTSTSMLIADELDLP
LDRVHVTLAPARPELLFNQLTGGSNTTISTYTPIRVAAAVARRALLEAAAIELGALVETL
VVKGGTIFDSLGSSLTYGQAAALAAPPTTRQVRVSLKTAAEQKVVGTPQRRVDALDAVTG
LKKYAMDLTEADVPGALPTMVCRAPDLNGTAREVRNRAAVLAMPGVTHVAVIPTGVAVRA
RTFGQCIDAVRALDVVWNAGSVPGRSAADIRKELRRAQLPLAVPKIGATTVEGDFVFHFR
SGSALEPNCAVADVRDGGATIWGGLKSPVDAQSKVAKALGLPQRKVTVNVVQGGGSFGRK
LFSDAAIEAAHASKAFGVPVKLMWHRADEPRQGRVHPMATSRVRATVLLGSVVTFEQRHT
SVSTDFTHGLGERLTAEVAALPTGLANLGFSETIFLLSQELPYNFGVVTQLLNESNQDVD
RFNTSSVRNIYSPDVRTANELIVDQLAARLKQDPVEFRRRHLKSRTVKRVLARAAELGEW
GRPMPAGTAQGIAIHKEYKGATAVLVEIDCRPETVHRKVRDAVTGPRVTKAVVVVDCGLV
VNPLGVEAQMMGGFSDGMAQALTYSNHLVDGHFLEASWDNSAYTRQWNTPFDFRCEVLES
DRREPGGIGEAGVAASMAAVACAYARATGTMPTEFPINVHAPLHFEPKPFVPSVPASPVD
GLDHVN
>A0A0A1DKL8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides simplex|TrEMBL
MPQHTFQLNGETVTVDVEDDVRILWVLRDVLGVTGPKYGCGINVCKACTSHLNGKAFNPC
SVRVQDVGPDDEITTIEGLADTVPGDGLHPMQEAWLEHDVAQCGYCQPGQIMAAVALVRR
VREEDRAITEDDLDAIRNVCRCGTYSRIRQAIRTGADLMG
>A0A6J5DR04|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia paludis|TrEMBL
MPISFVLNGKNVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTVHLEGQAVRSCV
LPLAGIAGKHVTTIEGLRSRPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
ADIDTAMNGNLCRCATYARIRAAIHDAAATLGA
>A0A484V566|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MAARLHVNGRDFTVSATPDTPLLYVLRNDLRLNGAKYGCAAAQCGACKIILDGRDVPSCV
VPLSAAEGRRVETVEGLARDGELHPVQQAFVDEEAAQCGYCTAGMVIAAKALLDRLPHPH
EADIRAALAAHLCRCGTYHRVIRAVQRAARVLQS
>A0A484U629|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MRLSVNGQLHTVEAEPAAPLLFVLRNDLALNGPKYGCGLGECGACTVLVDGVAARACVMP
VRGVLGREVTTLEGLGDSACPGPTQQAFIECQAAQCGYCLNGMIMMIEALLRRQPAPDEA
QIRQELRHNLCRCGTHLEILQAARRAVTLHAQARETACAKRSGQ
>A0A4V2ITC7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium leguminosarum|TrEMBL
MITLNINGNQHEVDADPETPILWVLRDTLGMTGTKFGCGAALCGACTIHLDGEAVRSCST
PLSAAEGLNITTIEKATDGSDRVGAAVSAAWVKHDVAQCGYCQSGQIMSATAFLASLPSG
SQPTASEIDTAMEGNICRCGTYVRIRAAVADAASNLV
>A0A1I0JIN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas graminis|TrEMBL
MQKLMINGQEHDLDVADDMPLLWVLRDVMGLTGTKYGCGIAQCGVCTVHLDGQAVRSCVL
PVSAVAGRKVTTIEAVGEQAVGQAVQKAWLDHEVVQCGYCQSGQIMSAVALLQEHPKAND
EQIVNAMSGNLCRCATYTRIRAAIKSVSQA
>A0A0M1IJA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MPTSFVLNGKNVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTVHLEGQAVRSCV
LPLAGIAGKHVTTIEGLQSKPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
ADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
>F6F2S8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium chlorophenolicum L-1|TrEMBL
MGRAPRKQGQQTERGLNRRALLVGGGATAGLLLAWAVWPRAYRANLNTAPGETAFNAFLK
IDRAGQIIVIVPQTEMGQGVSTLLPQILADELGADWRTIGVQSAPAGPLYANRLLARQWL
ANDWSRLAGEAGDWAIDQYATRSALMLTGAGTSIPMFHQPYREAGAAARVLLCKAAAARW
DVAWESCDIRDGIISDGGKRTLKLGEVAEDAATFDLPDILPFRQADVDRLAGQELPRLDT
PSKIDGSHVFAADVRLPDMVFASIRQGPIGDAVLKSVNEGAAKSVAGFLKLVRRERWVAA
VASNWWAANKALDLADPLFELAGKPVDSVGMEAALEQAFSASGERLYAQGDLKPLFKDAT
ILASEYRVRPGLHLAPEPMCATARIGDDGAEVWMATQAPGLARAAIARALDLTPGAVTLY
PLHAGGGYGRRMDYDAGVQAALLSREMKRPVQLLWSRLEDVIQDRPGAPAHARMAARLGR
NGAIEGWSAKVAAPCAMTQTWARIADGKPPHEAAAASADISTRLAVAGMELPYAVPNWAV
DHFPADIGLPLGFTRGNAHLHGAFFTESFIDELAHQARMEAMSFRIQMLGGNPRLAHCLT
TVGALGGWQGGIEGSGQGLAAHAMNGAYIAVMVEAAIVEGKLQVGRIVAAVDGGEQVNPD
IARQQVESGLIHGLAMAMGASVPYAKGLPTRAILGRMGLPRLADIGEVTVELIRSTAPPA
GLTDLGAPVVAPAVANALFTTTGRRFRSLPLLMEG
>A0A853SBT6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MYNITVNGQPFGTEADAETPLLWVLRDEARLKGTKFGCGIGMCGACTVHVDGRAMRSCIT
PIAAVAGCAITTIEGLSPDGTHPLQRAWLATQAPQCGYCQSGQIMQAATLLKDYPQPTDA
NIDAVMSGNLCRCMAYVRIRKAIKLAAGMQEAPGV
>A0A377RTS0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MTTLTINGKQHELALPEDTPLLWALRDELGMTGTKFGCGMALCGACTVHLDGVAIRSCVT
PVSAAAGKKITTIEAVGEDKVGLALQQAWQEHGVPQCGYCQAGQIMSATALLHKTPKPND
QQIREAMSGNICRCGTYTRIHAAIKQASASINAKGAAK
>C4I1G6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia pseudomallei MSHR346|TrEMBL
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
ADIDAAMNGNICRCATYTRIRAAIHEAAATLKA
>A0A1B8P443|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas elongata|TrEMBL
MAYRLALLNDKPRHRGVLKLAAEQAGWEKPLDAGAEGEQRGRGVAVHESFSSFVAQVAEV
TVKSDGSYSVDRVVCAVDCGVAVNPDVIKAQMEGGIGFGLAAAISGEISLDQGVVQQTNF
HNYQVLRMNQMPEVEVHIVSSSEPPTGVGEPGVPPIAPAVANALYAAIGQRLRRLPLGLP
>A0A7W8LEG4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia youngii|TrEMBL
MSQGLLDAQNGAQPTDTNARHAHGISRRTFLKFGATVGAAAGGGLLLGFSMPAASQDQKS
AKSVIGGDANEAPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LDSVTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARVMLINAAARQWQV
DPASCHAQGGQVVHAASNRSASYGQLAQAASALPAPQNVPLKDPKDFKLIGTPAKRLDSP
EKVDGTAQFGLDVRLPGMVYAAIANCPVFGGTLASVDAAHAKQIPGVREVIELDNAVAVI
GDHTWAAKRGLQALDIKWNEGAGAQVSMKRIVDDLAAASQHGGAVARKDGDVGRAFGDAK
SRVDAVYQQPFLAHATMEPVNATVHVRGDACEIWLGSQVPTRVVDAAAAVTGLPADKIIV
HNHLLGGGFGRRLETDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDTISAGLD
ANGKPIAWQHRIAGSSIMARFAPPAFKNGLDPDAVEVAADLPYDLPNQLVDYVRVEPHAV
PTAFWRGVGPTRGTFVVESFVDELAAHAKIDPVQYRRNLLGKSPRALNVLNVAAQAGNWG
SALPKGQGRGISVMHAFGSFFAIVVEVAVEQGEVTVKRVTCAVDCGMYVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRILRINETPPIDVHLVKSGEAPGGIGEPGTA
ALAPALTNAIYAATGTRLRQLPVGRQLHSA
>B9BNS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD2|TrEMBL
MVTLKINGTIHEVDIPPDMPLLWVLRDVVGLTGTKFGCGIAQCGACTVHVDGQPMRSCVT
PAAAIAGRDITTIEGVAATAAGRKIQQAWLALDVVQCGYCQSGQIMSAAALVNGQHAPTD
DDIDTAMAGNICRCGTYARIRAAIKLAVREN
>A0A2I7JXR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter inhibens|TrEMBL
MASLKKIARRSFLIGSAAIVGGVAFGTYKYHQPAPNPLDQKDGRAVLNPFVFVDQSGVTL
IAPRAEMGQGVKSAWASLIAEELDVDPAKVTVLHGPAAKAYYNSAMMSEALPGRGYDGSA
LQHSLGEIVGHMAKFLDLQVTGGSSSMRDGFERMRHAGASARETLKQAAADQLGISRDQL
TTEDGHVVAPDGTRLPYADLARTAANLTPIETDLRPASEWRLIGKDVPRIDMVAKVTGTA
EFGVDVRLPGMKFAAIRQSPHFGVGKKNFDASAAETMPGVEKVLDLGDAVAVVASNTWLA
QQAVDAIDVTWEAAPYPETTEAIFEEIARSFDATPNSTMRDDGNVDALPEGATVIEAEYR
LPYLAHATMEPMNATALYSGDGLQIWAPNQGPTVVQKKAAALAGLDVDAVEVNTTYLGGG
FGRRIETDYTDRAVQIAMQMQGTPVQLTWSREEDMRHDVYRPGAIARYRAAVKDGKAVMV
HGKIAAQSTTVEGAGRMLGLPMSGPDKGHVDAAFNQPLAIPNFRVEGYLAKPMLPVGFWR
SVGASFNGFFSDCIIDEMAHAAGRDPLEFRLELARAEWEPAAKVLETVRDMSGWTGKTPH
GIGRGVAMAYSFGTPVAQVIEVADQDGQIRMTDAWIAADLGRVIDPKNTRAQMFGGMVYG
LSAACFGEITIDGGAVEQENFPDYDALRMHTMPTVQVELLENQPRMGGAGEPGTPPAAPA
LANALFDLTGKRARQLPLMHEFDLLI
>W6V6G0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. (strain GM41(2012))|TrEMBL
MNNLNPLSRRGFLKGSAVLGGGLVVAFVIPGGHRFAVGAENQGNVFAPNAFLRIGNDNSV
TILLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAAEYGLAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSGILTESGVVIAGDQRATYGELADDAGKL
PVPDPASIKLKESKDWKIIGKPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVDWDLGPNTGLDSQTL
LESFRKLAATPGASASQAGDVAAGLGKAAKTIDVEYSVPYLAHAPMEPLNCTVKITQDKC
EIWTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVEVAKAAG
APVKTVWSREDDIRGGYYRSAFLHQARIGLDAGGLPIAWKHVMVGQSIMAGTSFEATMVK
NGIDKTSVEGVADSPYLEGLANHQVYLHSPQTGIRVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKNGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A446CD82|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter agilis|TrEMBL
MTLTMQLSRRSFLQGGLGALTLAITSKGLITTVWAAEAAAQKYGADSMPGGTVEDPLVFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWDRVKVIQAQADEVRYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAAQWSVPVAEVKAVQHEVLHQPSGRRLAYGELAAD
AARQPVPTGDALKLKDRSEFRYIGKDQVRLVDLEAIGKGQASYGMDMRLPGMVYAVVARP
PVVGGKLRRFDSTKALAVPGVLKVVEIPPMQGAPAFQPLGGVAVVARNTWAARQGRDALE
IEWDDGPNGNYDSAAYRQALESAARKSGKAIRNQGDVAQVWTKAPETDRLAAEYYVPHLA
HASMEPPVATVQIKGNNAEVWTSIQNPVAARDAVAARLKLDPANVKVNVLLLGGGFGRKS
KPDFVDEAAIVARAMPEGTPVKLVWTREDDIHHDYLHTVSVERLAAVLDKSGQVQSWLHR
SAAPTIASLFSVGAKGQQMFESAMSAINMPYRIPNVRVETAEVEAHARIGWFRSVANIPH
AFAAQCFIAELAQHAGKDPRDFALDLIGPARRIDPGTLADTWNYSESPERYPYDTGRLRG
VIEAACKGAEWGRTLPKGHGLGLAFCYSFMSYTATVVEVAVDEKGEVRIVAVDMAMDCGP
QINPERIRAQMEGGAIMGLSLALTGEITFEKGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHALPPGGVGEPPVPPVAPALCNAIFAATGKRIRNLPVRRVA
>A0A1V5TRR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ignavibacteria bacterium ADurb.Bin266|TrEMBL
MPKYKLNVNNKNYNVTVEAGTPLLWVLRDNLNLTGTKYSCGEGLCGSCTIHIDGKAERSC
IVSVEEAVDKKITTIEGLAENPDHPIFKTWIELEVSQCGYCQPGQIMTLAAMLDSDSRPS
RKEIDNTMSTVLCRCGTYHRIRKAIDKIVEEKQ
>A0A7W7JZK9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kyeonggiensis|TrEMBL
MKVDVGKLQKLDRRTLLIGGGVGVGLVVAWAVWPRTYLPNLTAAPGESLFGAWIKIGTDG
HVSVAVPQCEEGQGVFTAMPQIIADELGADWKLVGVEPAPLNPLYANPLAAEELFELALG
GLPEQLRRTHAARTGLMLTGCSTSIRSFEDQLRHAGATARVLLCKAAARRWGTEWQSCDT
AAGQVIHGNSKLGFGALAAEAAAESVPGDVPLRTGETNRLFGQPLPRLDAPAKVDGSLVY
AADVRLPNMVFASIRMGPIGETELVKLDRAAANRIPGMLSIVTTKDWVATIANNGWAAEK
AIDAMRPRFKTPEEVINNDSIADALNAAFDADGARVHEAGNLAADFRGAKVVSAEYRVDV
ALHAALEPMTCTAHYHDGLLSIWLPTQAPGLARAAAARAVGISEGAVTVHATMAGGSFGA
KLEHEVAAQAALLSQSVGRPVQLTWPRGEDMRHDRYRPPAIGRMTGKLNPQGQVTGLLAK
ISTPETGRELATRLLGGDPVVQASLALPGKGDPSAVAGAQPAYGIANYAVDHHPAAIGVP
TGYWRSGAHSYTCFFTESFMDELAHVAEQDAVSFRMAMLGGETRLARCLQTAAQLGGWQG
GQPGSGQGIACHAFRGSYIAVMAEARLEGRKVKVERLVAAVDCGRVVNPDLVTQQIEGGL
LFGMAAALAGSTSFTENVADVRELSELGLPTLADAPDITVEILRNGADPGGVSELAVPPV
APAIANALQSASGVRFRVLPLLSDAE
>A0A1V0Q1Z5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MSRRTRLSRRLFLASAGGMTVAVGLGAGRALWPTPGPRAGQAVNAWAALLDDGRVAFACP
AQDLGQGAPLALSMILAAEIGADPGLVAVQAAPRDAGTYGNPDFDGRMVTADSKTTRGYW
PLLRLAGAEMRAALIATAARMQGWAEADCSTAEHSVAHRPSGARVSFAEIAANGRLRMPG
TPGLRPGVELTPLGTSPDDPRMRAIVTGQKRFGTDRRATDASVAVLARSQHLDGLPLTVD
DTAARAVPGVEAVVILDDAVAVVARHTWAALKGREALVVRWSDPGGFDSETEAETLRAAL
DDDSQKCVTLRATGVATGAPTLTARFHAPMLKHLVPEPLNAQARGKDYGLGVTVESATQS
LDLDMRFAAQTWKTAPFMVETIAHPAGGAYGRRVLNDVVRDACAVTKSLGRPVQVIRPLV
DELQRGQVRPAAAQRVAAWLAPDGTLSGWSHDFASDGPLAAQLPASLKGANGDEDNTATD
GAYHPYRVPADRIRWTRVATQPVPGFLRGVSAGYTVWRSRP
>A0A2P9F068|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. MA5143a|TrEMBL
MSRHSRRGFLTYLVAAPTLAVATRIGLDAYAPGTADAVIPTPPAPADLVDLGDLLILAGA
PTANMLVLSVDEEGLVHFRLPREEVGQGLTTAVAMLVAEELDTPLDHVRVRLDDARPELL
FNQLTGSSNSIRSLYDPVRHTAAAARARLVGAAARQWALDADELTVRRGVVVAPDGRTAP
YGSLSTAAASLDLGSLVVAPKKQSEHTLVGTPTSRIDARALVTGKQAYTLDLDVPGAKPC
MVRRPPTINGTVKAVNNEATVRAMPGVLDVVTIDTGVAVVAETFGQALDGKEALDVTWGP
GTVDALSDQEIRAKLKAATPSLDVLGPLVKKVEGEFDFAFASHAPLETNSAVADVRADRA
EVWSGLKSPIVAQAAIAKAVGLPVSKVTVHVVQAGGSFGRRLFYDAALEAAVVSKKSGRP
VRLMWSRIDDMRHGRMRPATHHKIRATYAAGQVLTFQHRVAAVETDFRHGLGDALTAAAA
SLPAGIGNATFAQTLFLTTVKSPYHFGITTQTLTEVPIRMHTGSWRSVYSANTRGAEEII
VDELAARLGKDPVAFRREFLRTARQRAVLDKVAEEGEWGRDLPDGWAQGVGFHDEYKSCT
ACLVEVDATDPKKPRVTRAVIAADVGRVVNPRGLEAQLLGGLTDAISTTLRAGLHIDKGL
PLEGSYSQFHYARQKDSPKDVRIHVIEGADEPGGAGELGVPAAVGAVANAYARATGTRPR
SFPVSFDVDFTPFPR
>F9YBB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ketogulonicigenium vulgare (strain WSH-001)|TrEMBL
MAYTLNINGESRTVDAAEGTPLLWVLRDDLKLTGTKFGCGIAACGACTVMMNGEPVRSCQ
QKVETLEGAEITTIEGVSGNIASAVQQAWAELNVVQCGYCQSGQIVQAIGLLTENPKPNA
DDIDTYMSGNVCRCATYQRIRGAVLRASEIMEA
>A0A6J4LG10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Cytophagales bacterium|TrEMBL
MNPEIQDKPLNRRRFIRLSGLSGAVLALGFSFPATGQEGATLHNLSEDIPAARELNPFIL
IDASGKITLMLHKPDMGQGTYHAMPAILAEELEVRLDQVVIQPAVAHKKYGDMGVGGSNS
VKGSWDTLRKAGAAAREMLTKAAARQWNVPESDLYAREGKIYHKPSGKSLGYGELVEAAG
KLPVPKEPKLKDPKDFRLVGKSTQRPDVPLKVDGTAQFGIDVKIPGMLYASIERSPAYHG
KVRDFDDAAAKAVPGVKHVLKAERKLNKNVFEGVAVVADNYYAATQGRKALRIIWEDGAA
AGVNTSAMYARFRELARTEGHVDKQAGDFDGAYAKAAKKLEAVYELPFAAHAPMEPQNTV
AHVQGDTCEIWSPTQVPDWARGELAKYLNIPEDNITLHFTFLGGGFGRRLFFDSILEAAY
LSRQLGVPIKSVWSREDDMTAGPFRPGTLSSLRGGLDAAGKVVALQHKVVAPSISFNNFG
ARDPKHPEDEGAMEGIKDSPYEIPNHKYHNIYAETPLPLGWWRAVYSTTTAFAHECFVDE
MAHAAKKDPLQFRLDLIGANTRMKQLYEALREKSGWDKPLPPGWGKGVAAWQFFAGQAGH
VVFVSKAAEGGVKIEKIVAVIDCGTALNPDNVKAQVEGATVMALTAALKDEITFEGGKPV
QKNFDRYRMLRMDEVPPIEVHLVAGREKPDGVGEPGLPPLAPALGNAIFAATGKRVRKLP
FDISRIS
>A0A7X0JA78|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas endophytica|TrEMBL
MTRLTVNNEAVEYRMASDTPLLWALRDASNLTGTKYGCGTGSCGACTVDIDGKAVRSCQV
ALRDVEGTFVTTIEGLSRERAHPVQLALIAGNVPQCGYCIPGITMAAAALLKRDPMPSDE
AIRAAITNICRCGIYPRLVEAIQRAGRAIRGDERLPAAPRPGIDPAEAARRVPALDPAAG
R
>A0A5S9PMQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Starkeya sp. HF14-78462|TrEMBL
MKFTLNGSERTLEADGQMPLLWAIRDIVGLTGTKFGCGAALCGACTVHVDGVPVRSCQTA
LADVEGKNVTTIEGVGGEVGEAVVAAWRKLDVVQCGYCQSGQIMSAVGLLSENRKPTDED
IDSAMDGNVCRCATYQRIRAAIHEAASNLA
>I3X4S6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MAIVTINGVEHSVDAEADMPLLWVIRDLVGLTGTKFGCGMAQCGACTVYVDGSAVRSCQT
MIGDIEGAQITTIEGLKGKVAEAVQAVWADLDVPQCGYCQSGQIMSATELLTSNPKPNDE
DIDAAMSGNLCRCATYHRIRAGIHEAAKRLEG
>A0A7W8XZ33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium paranaense|TrEMBL
MSNRMNGPSLNRRSFLKASAALGGGLIVSLGPLSTGPLGATDFAPNGFIRIDRRGLVTLV
MPQVEMGQGIYTAQAMLIAEELDVSLEEVKIEHAPVNEALYGHPMLGRQMTGGSTSIRAF
WTPLRTAGATARLLLMQAAASEWKVDVAACKTEQGFVLNPDGRTRRAYGELVDMAASMPI
PPADTITLKQPADFRLLGTSAKRLDTRSKTNGALIYGIDASPAGMKFAAIAIAPVLGGKP
ISVNQAAALAIKGVKQVVITEDSMAVVADHTGAAKKGLKAAGIAWEDGANGTVSQADILR
QLDEQSQENGAVARSEGDVATALSSAAVTIDAVYQLPFLAHTAMEPMNCTVHVREDTCEL
WVGTQNMSAAKQAAAAVTGLQPEKIIINNHIVGGGFGRRLEADGIAHAVKIARQVQGPVK
VIWSREEDIQHGYYRPYYYDRISGGIDQDGRPIAWSHRVSGSSIFARIAPAVMQNGVDPD
GVEGAAHPPYKLPTIHVEFKQVEPPGVLTSWWRGVGPSHNIFVVESFIDELAAAAKTDPV
DYRKRLLSENPRALAVLELAAEKAGWGKTLPERQGRGVAVQFAFGTYLAMIADVSVATDG
TVRVPRIVTAVDCGLTVNPDTIAAQMEGGALYGLTAALYGAITFAQGRVEQNNFDTYLPL
RIDEAPHVETHIVRSVEAPGGIGEAATSAVFPAVTNAIFAATGRRVRTLPINPEELKA
>A0A7W9D4I3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium paranaense|TrEMBL
MSVSVNRRAFLLGTGALAGAVVFPITSSGAQPSSALKAEGIEILSWIVINPDNTVTYTIP
QTEVGQGVTTTIPQMLAEELDSDWEKTNVAFYDPAISKARGTPYVWTTTLGSLSAHYLFA
PSRLAAAQVRAMLIESAAARLSVPAEELTTSGNQVHHGKSGRALRYADVAAAAVKLTPPP
AEKVVYRSVADRRFIGKPIAPRSTVPATRGEIVYGIDVDLPGMRYAAVQQSPVFGGNLVR
IKDEALKGLPGHPVIVKIKGGFVGYNSPVPDGEDPDLWAAAVNIDDTVAVVADSWWEAKS
ALESLEIEWDGGPHAALTSETLKSSLSKQAGGELPVLVETGDVAKRMKEAARSLTAEYVF
PFMDPAPLEPLNCTVLIEKTKATVWAGSQYADDAHRIATELTGAAPENVKFNLMQCGGGF
GRRVQNDFVYQAVQVGKAMLGTPVKVLWSREECIKRSTYTPLTVVKFAGALDDDGNIDTW
SCRIASAQAALQSYGGTHFPFFFPNMQIAYQRDKTTPIPFGWMRGVGLTQHLWMNFGFLD
ELAVLADKDSVDLYRALLDPSLIPKGLENYNIAVARSQTLRRVLDAAAEKAGWGERAKTG
SGRGIAVSDTAYYLGYESSSKAAVVDVTIKDASVRVNKVAITIDAGTIINPDIVRQQLEG
CISYALTNAFYSEITVEDGQVQQNNFYDYPILRIGQVPEIEINLLPSDGSPQSVGEDAVP
ITIAALVNAIADAGGPRIRSLPIKELTLV
>A0A0M2WJI7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. KBS0711|TrEMBL
MAAEKNTSRRRFLLGGLGLGVAGVGALVLGWGVLPPRQRLHGSAPLPLVDGAVALNGWLA
IQADGSVLLAMPRSEMGQGVHTALPMLVAEELDVSLASVKLIQAPNDKIFGNVAMLKDSL
PFHPDDQGRLKALAQWTVAKAARELGVIVTGGSSSVKDGWGPMREAGASARAMLVGAAAA
LWQVPAAQCRTQDGAVIHPDGRRASYASLAQRAASIDPGTPVLKLPKDFKLIGQPAPRRD
TPSKVNGSARFGIDARPPGMLYAALHLPPRLGDTLSAFDAAPILAMPGVKKVLDLTPQLA
RRSVSCAAVVADTWWRAKQAAAALPTQWKAGPQANLSSAAVYAEFARLLDSEAGYAYHAS
GEVENKAVQGMRQISAEYRAPFLAHAAMEPVNCTAQVKNGKVMLWASTQAPGIAVDVAAK
VAGVDAKDVSIEVLLLGGGFGRRLEVDMIAQAVAIALQCDGAPVQLVWTREQDTKHDMYR
PAALARFAARLDEHGSIASWDNKSVSGSITHQYLQRNFGLPGAGPDKTTAEGEFDMPYEI
ANQRIAHVIADSAVPIGYWRSVGHSHNAFFKESFIDELAHAAGQDGIAFRRAMLVRHPRH
LAVLDAAVAKAGTPPPGHAHGVALHQSFGSIVAQVAQVSVENGEIRVQRVVCAIDCGIAV
NPNIIAQQMESAVLFGLSAALGGEITFKEGQVEQGNFHDYPVLRMGQTPEVETVIIASAE
HPEGVGEPGTPPIAPAVANAVFSLTGKRLRSLPLRLA
>A0A1X6YF12|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria meonggei|TrEMBL
MATSLKVNGTSHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VTLSDVWGDVTTIEGIGSPDAMATIQQAWVDHQVAQCGYCQSGQIMQAAALLAENPDPTD
TDIDDAMQGNLCRCGTYPRIRAAIQDAALKLKEV
>A0A7W8NB26|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. ANJX3|TrEMBL
MLSLQVNGESHSVDVPPDMPLLWVLRDVIGLMGTKFGCGIAQCGACTVHLDGQAVRSCVL
PVGSIGNKAVTTIETVGQTPSGQKIQQAWLDVDVVQCGYCQSGQIMSATALLARTPNPTD
ADIDAAMSGNICRCGTYVRIRAAIKQAATGKLEILQTTVTSPAAPAAEATP
>A0A840BYD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chelatococcus caeni|TrEMBL
MKLTVNDREFTIDADPEMPLLWVLRDVIGLTGTKFGCGAAQCGACTVHVDGQPIRSCVTP
VSAVEGQKVVTIEGLGGNKVADAVITAWTALDVPQCGYCQSGQVMAAVALLTETPKPSDA
DIDAAMDGNLCRCATYQRIRAGIHEAARTLEG
>A0A085FFC4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. LC238|TrEMBL
MDTIERSTKPAQPKEAKPEAGAPRAGARLTRRRFLLGGLLAGGAMLVGWGVQPPRQRLHA
SRPLALGGDTVGLNGWIAISPDGAVSVVVPRSEMGQGVHTALPMLVAEELDLPLSSVRIA
QAPIDKIFANLTVLRENLPFHPDDSGSTRQGAQWLMAKLGRELGIMFTGGSTSVKDAWLP
MREAGAVARAMLLKAAAEQWKTPVARLRTEDGFVLHPDGRRAGYGALAPHAARVGAGIEA
GDVRLKEPRDFRLIGKPAGRLDSRAKTDGSARFGIDARVPGMVYAAVKMAPVIGATLTKH
EGKGVESMPGVLQVVPMPGLMDERSGLGVGVAVVATTWWQAHQAAQALLVKWQVGDTSRL
SSESVFEDFERALEEESGYVYHEAGSQDVDGVALTVTAEYRAPYLAHAAMEPVNCTAQVE
YVQGRARVRLWASTQVPSIAVDVAARVAGVEREDVSIEVMLLGGGFGRRLEADMVAQAVT
VAMAMHGKPVQIIWSREDDITHDVYRPAALARFRAHLDARGEILAWDNKSASGAIGHQYF
PRNLALPGMGPDKTTAEGEYDMQYAIANQRIAHVIVDSPVPLGYWRSVGHSHNAFFKEAF
LDEVAHAAGRDPVAMRRALLGKHPRALATLDAAVAQAGQPAAGRAHGVALHRSFGSTVAQ
VAEVSVEGKQIRVHRVVCAIDCGLAVNPNIIAQQVESGVLFGLSAALHGEITIKDGKVEQ
SNFGDYPVVRMHEAPVVDTIVMPSMAHPEGVGEPAVPPIAPAVAAAVFKLTGQRLRSLPL
RLS
>A0A1V5D8A8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Syntrophorhabdus sp. PtaU1.Bin153|TrEMBL
MREIVNFSRRAFLKTGALIGGGLVLGIVGPANGTRAYAATVPEAPFIPEAFVRIGTDGAI
TIIVNKSEMGQGVYTSLPMLVAEELECNWSKIRVEAAPVDPVYNHTVFGMQMTGGSTSVP
TEWERMRKVGAAAREMLVMAAADTWKVQKEACRAENGVVYHGTKKFTYGQLATKASGMPV
PANVQLKDPSLFKIIGKPTHRIDSPEKVNGRAVFGIDVTAPGTMIVLIAHCPVFGGKAKS
FSSEKARAVPGVKDVVQIASGIAVVGDNFWSAYKGRNALEVVWDEGPLAGLSTSGMRKEY
AALVQNPGIAARKEGDPEKALGTAAKTLTAEYEVPFLAHAAMEPLNCFVDLRAGSCEIWT
GTQSQTADRDAAAQIAGLKPEAVKLHTAFLGGGFGRRANPHSDFVSQSVQVAKAVKKPGY
CQHNCVNFL
>A0A238H2H8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia singularis|TrEMBL
MITLTVNGRERHFDGNPEMPLLWYLRDVLGQTGTKFGCGMALCGACTVHLDGVAIRACIT
PVAAAAGKRVTTIEGLSSDVSHPLQRAWQELNVAQCGYCQGGQIMQAASLLKTNPHPSDA
DIDEAMAGNICRCGTYTRIRAAIKLVASRGGSV
>U2WV70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MRSYLLNQFLFGFIILKIIMVPSVLLADDNPINTDILEIKTLGKKWLELYRSSNIEKFMD
QYTEDALVALNGKPALKGKEAIQAYFESRIGKKNVDMRLDYEKISINQNIAVVVAKFYLD
YPFEERIETVGGRSLIVYKKSDLGKWLIDVDIDQKTPDAN
>H0TSS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MTPATLRLTVNGQAHDVAVGPDTPLLYVLRNDLGLNGPKYGCGLGQCGACAVLIDGQAAR
SCVFPVGGCLGHDITTLEGLGSREQPDAVQQAFIMEQAAQCGYCLNGMIMTTKALLAINP
RPSEEEIREALRYNLCRCGAHVEIVRAAMRAAGHTLEALD
>A0A081FV93|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacterium sp. AK27|TrEMBL
MSAQLSRRNFLKAAGASALLVGFTPRGLLAAGYEDSTLNPFVRIDSDGVVTVILKHFEMG
QGTSTGLTTLIAEELDADWASVRIDFAPSDTAKYKNLLFGAQGTGGSTAIANSFMQYRKA
GAAARDLLVRAAAEQWGVGVDRIRIDKGVITDGQRTAGFADVIHSAARLEPNPEPQLKTP
DQFKLIGKLKLPRKDSIAKTDGSAQFAMDVKLPGMVYAVILRSPRFGGRLTGFNADKAAE
IAGFIDAKALPNGAGVAVYGKNTWAALKARDAITAEWDFSDAEMRSTGALIEAHRELTAA
PQYQARALTTDAVQARLSAAPRTLDAEFVFPFLAHSPMEPLVCVIEPTASGVRVHDGCQF
PTVAHGALSSVLKLKPEQVEIKTLYAGGSFGRRTTPTADYHVEAAMAFALLGGKTPVKML
WSREDDIHGGYYRPMALHKASIALDADGAILGWDHRVAAKSIVKGSAFESALVHEGLDHT
TVEGLADTLYQVPNMALGVSDFLSPVPVLWWRSVGNTHTAYVMESLMDMLAHERGEDPIA
LRLSLLDRSNKEQARMAGVIEAARDMSGWQPGQKRGFAAHYSFNTFVAVVADITVEGNKV
HVDKLHMAVDCGVAINPDVIRAQMEGGAGYALGAIMRNEITLDQGLVVQDNFPQYLPLRM
PDMPEIAVTIVPSAEPPTGVGEPGVPPTGPALANAIFAVTGKRITELPMTTAGFSFV
>A0A7W3IW34|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides ginsengisegetis|TrEMBL
MPTQTFVLNGKSITVDVHDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVRVGDLSSDDEVTTIEGLPDTVGRDLHPMQQAWLDRDVAQCGYCQPGQIMAAVALVRKT
RREGRSITEADLDGIRNICRCGTYTRIREAIKQGEQHM
>N1MHP2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium japonicum BiD32|TrEMBL
MARFPRKKTDRIKGIDRRTLLVGGGAAAGLLIAWGTWPRRYAPNLNAAPGETIVNAFLKI
DRSGQIIVIVPQTETGQGVTTILPQIVADELGADWRTVAVQSAPISPLYANTLLARDWLA
SDWTRLLGDAGDWALGQYATRNALMLTGGGTSVPMFHAACRDAGAAARVLLCKAAAANWD
IPWESCDIQNGLISDGGDRRTKIGDVVEQAIGFDLPAILPLRQGQDGRLAGLDLPRLDTP
SKIDGSHNFAADIRLPDMVYASIRQGPIGDATLAGLDERSASGVTGFLKLIRQDRWLAAV
ATNWWAANKALDLADPIFTLRGTPVSSATIDDALEAAFSGTSGRRLYAQGDLLPVFEGAT
ILASEYQVDAGLHLALEPLCATARVTDDGAEVWLATQAPGLARAAVADALGLPESAVTLY
PLHAGGSFGRKMDWDVGVQAVLIARDMGRPVQLLWSRLEDVIQDRPAAPAHARMAAKLGR
TGAIEGWLAKVAAPCAMTQTWARIADGALPHQAAADTADKATRLAVAGMVPPYAIPNWAV
DHYPADVGLALGFTRGNAHLHGTFFTESFVDELAHLAGMEAMSFRIQMLGGNPRLAHCLS
TAAAMGGWQGGIAGSGQGIAAHMMNGAYGAVMVEASMRGNRLSVGRIIAAVDVGDQVNPD
IARQQIEGGLIYGLATAMGASVPYEGGLPTRAILGRMNLPRLADIGEVTVELIRSTAPPA
GVTDLAAPLVAPAIANALYTWTGQRLRSLPLLGTT
>S6CYI5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus 386B|TrEMBL
MAASVFLTVNGCRHAITAAGNTPLLAILRNDLGLNGPKYGCGLGACGACTVLMDGKAARS
CVVSLNAAAKCKNIVTLEGLSPDGSDPVQKAVVAAQAAQCGYCLNGMVMTLRAFLDANPH
PDEDELKAALRYNLCRCGTHVEIMRAARIAAGLEKEDSGK
>A0A7W6YZ43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MHNDKQALKDAHGTARRRFIKQSSALLASGLAIGFQLPEAFAAEANASGDPKPQPGEFEP
NAWVRVLPDDTIKLVVHKHDSGTGTRTALAAVVAEELDVDPFRVEVITPENPFFGDYIHP
LWKVFSTGGSTSVSLEYERLRRAGATARAMLMVAAAKQWNVPPSSLSTENGFVVDKASGK
RANYGSLASVAAQLPAPKDVALKDPSQFKYIGKLQKKRGADLKARGAFPYSIDVSLPGML
VAVVTRAPVIDARVRSVDAKAALAVPGVRQVLQIPGRPDLLGGNQAGVAVLADDYWSAHQ
GQAALKVEWEDSPLETFDSSTLAARQAAWLDDPVAHVVPTIQTGDAKTAWPHGAKVIEAS
YSMPYKAQNALEPINVTAWARDGRIEYWGGLQVPSTVQEAAEVIGGIPAERVVLHELVSG
GSFGSRESKYWLFEVTWLALKVGKPVKLMNSREDEMRALFYHSASYHRAKAAFDAHGNLT
TLQLRAVMPASPEQWEPGYFDRPDRMDYSTTEAISKYEFAYDAPHVDIGWVRHETGVPTG
WYRAVSYIPNVFAVESFMDEAAHAARRDPIEFRLAYMKDPRHKAVLREAAERAGWGKALP
AGTALGVATNQAYSSYVAVVARVVRKGDAVVVEKLTCVADCGLAVSPGGVEEQLYGGLMW
GLGHATADRIDIRHGQVEQKNFDSYRVMRMSDMPEVDILIVQGDMAKPGGVGELSSPSVA
PAVANAVFRLTGKRVRETPFELDRVTVEGTGGGKAKG
>A0A0K8P4C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MARLNVNGTSREFDAEPDTPLLWVLREQLGLTGTKYGCGVAQCGACTVHIDGSAQRSCVR
PVSSVGEGERIVTIEGLSPDGSHPLQQAWAALDVPQCGYCQSGMLMAAAALLKDKPQPTD
ADIDAAITNICRCGTYNRVRAGIKLAAQGGAALRARLDSPTTDGRLA
>A0A7W8S6J6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MAVLNINGRKVKIDADPDMPLLWVLRCDLGMTGTKFGCGVGICGACTINLDDAACFACQT
LMSSLHTQKITTIEGLQGREAQALKAAWIELDVVQCGYCQSAQLMAACALLKHKPDPTDA
DIDEAMTPVVCRCGTYPRVRAAIHQAAAKVRNS
>B9NLG7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium KLH11|TrEMBL
MFFKSNRETADMPTSLKINGQMRDVQASEGTPLLWVIRDELKMTGTKFGCGVASCGACTV
HVDGQPVRSCQTYVEDVEGAEITTIEAMSEDKIGAAIQQAWVELDVVQCGYCQSGQVMSA
VGLLSENPKPSVEEIDEYMWGNTCRCATYQRIRAGIQRASEILEG
>A0A7Y9VYQ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDALAEDKPKQFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECRAQLHKVIHTPSGRELGYG
ELAAAASALTVPTRDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAVYGADVHFDGMLFA
VIARPAVYGGKVKSVDDSAALKVPGVLKVIQIEPRPLPSEFQPLGGVAVVASNTWAALKG
REALKIDWDDGPNATYDSVAYRKEIEAASLKPGKVVRNTGDIDKAVSSAASTLEASYYLP
HLAQAPMEPMVAIARYKDGTCEAWAPSQAPQVTRERIAERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAVLAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGVGKDGLPSAWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAKEDPLQYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRQLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVWGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPSEVPLGGVGEPGVPPIAPALCNAIFAATGQRIRNLPVRYQLQGWQKAQA
>A0A653JNS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus sp. 109|TrEMBL
MATTLNINGKDETVEAAAGTPLLWVLRDHLKMTGTKFGCGIAQCGACTVHVDGTPTRACI
TPHDSLDKAKITTIEGLSGAAADVIRDTWVENDVPQCGYCQSGQILAATALLSEKPSPTD
GDIDAAMSGNICRCATYMSIRRAIKQAAGKL
>B3R3F7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLGQVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAALRLGVDAAALEAENGEFRVRGTQTSIGYAALV
AGEHVELPLADDVLTKPVESYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGACVGTSLLSIDRESVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
KPVPPLPALDDPEPALRANPATRRELLTEGKLPAAGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDERAADLLRAVADAAGWQRGAAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLTVDAATGRITIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQALSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIDVVLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMASEKG
>A0A3S4CFR4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paracoccus haematequi|TrEMBL
MTRLRVNGRDHDLDVDPETPLLWVLRDELRLTGTKFGCGIAQCGACTVMLDGMPRRSCVT
PIGMIEGSEVTTIEGMEGPEVAAVQAAWTAIDVPQCGWCQSGQVMSATALLQQIPQPSDE
DIDNAMAGNICRCATYVRIRQAIHDAARTLEG
>D8P2J9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum CFBP2957|TrEMBL
MVTLNINGKPVEVDADPSTPLLWALRDNLGLTGTKFGCGIASCGACTVHLNGQPTRSCVL
PISAVVGAQITTSEHIADDRVGRAVLEAWVKHDVAQCGYCQSGQMMSAVGLLRSKKAPTD
ADIDRAMAGNLCRCATYQRIRAAIHDAAKALA
>A0A7W9AEX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium boeckii|TrEMBL
MTKLTVNNQPVQYRMDPATPLLWALRDASNLTGTKYGCGRGDCGACTVEIDGEAVRSCRM
TLAEAEGRFVTTIEALSRDRSHPVQQAWVAEGVPQCGFCQSGMIMAAAVLLKKNPNPADA
DIDAAITNICRCGTYPRIRAAIRHAARVNAGAEPIAAAPPPGIDPADAARAVPALTPPPA
KPGS
>A0A7W9ALA6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium boeckii|TrEMBL
MNYTLTINGKRRSVDVAPEMPLLWVLRNELGLVGSKFGCGMGVCGACTVHVDGQAQRSCS
LPISDVGTAKIVTIEGVGATPVGQRLQKAWLDIDVAQCGYCQAGQIMSAAALLQQTPKPG
HEDIVSGMSGNICRCATYDRIQKAILNAAGKMEAVDAA
>A0A177I3Z0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHLGGTAARSCIT
PVSAAEGQEITTIEGLSPDGNHPVQVAWRDLNVAQCGYCQTGQIMQAASLLKDSPKPTDQ
QIDENMSGNICRCGTYPRIRAAIHQAAGQTAPATKGDRL
>A0A0P0LH68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limnohabitans sp. 63ED37-2|TrEMBL
MKTMNTPLTPSVSRRSFILGSGGLALGLSFGLTQTELALAQAPGAGGFAPNSWINIGLDG
VVTLMSPASEMGQGTMTAMPMLLAEEMDLDWSQVRVVQSPSDPKRFGNPRFGGGMTTGAS
RTVQGYYEPLRLAGAQARLVMVNAAAQAMGVPAGELRTEASRVIHSGGRSMSYADIAKVA
TVPAELPKVDKSMLKPMAQFRLIGKDIPRVDVPSKSSGQALYGIDQRLPGMLWASVLRAP
VQGETPESVDDSAARAVAGVKNVVRLPYGVAVVADSFYTAKVARDKLKVVWSQKSKARVQ
YTDQMRVEYTKRAEDLNDKGVAFIAHGDAAKQLAGATRTFSATYTSEMVSHICLEPMNCT
ARVDGDKIEVWAPAQSASFVTGTVAGAAGFKPENIKVNITLLGGGFGRRVEADYSADAAL
VAKAMPGTPIQVIWTREDDIVHDKYRPMTGQHLVAGVDAQGKLVGLLHRVVSEGIYSRVV
PPAFKAAGGKDAPVMEGTEITYDIPDHSVQFMIEERGIQAGFWRAVGPGYTKFAIETLID
EVARGVKADPLAYRMDLLKKHPRGQAVLKAVADMSQWGKAKLPKGHALGLAFSDAWNTYC
GMVVQVSIANGRPKVHKVWTAVDCGHALQPQNIQAQIEGSVIFGLSAALHEHMDFRAGEP
QQTNLNKYQVLRANETPEVMVKVMPTDNHPGGIGEVGLPPLAPAIANAIATLNGKRLRAL
PFPMV
>A0A0P0MAU4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limnohabitans sp. 63ED37-2|TrEMBL
MVRFKVNGEAVSVDATPETPLLWVIREKLNLTGTKFGCGIAQCGACTVHLNGDPVRSCAL
PVSAVEGKNITTVEGLMKTPTGQALQAGWVKAQAPQCGYCQSGQLMTAAKVISVVKKNLS
RTEILEAMSGNICRCGTYNQIASAVSHAQKTLQGGKA
>A0A0P0LJA5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limnohabitans sp. 63ED37-2|TrEMBL
MQLNINGQSHTATSDPSTPLLWVLRDELNLTGTKFGCGIAACGACTVHVDGQPVRSCVTP
TSAVANRPIKTIESLGTAEKPHPLQAAWIAEQVPQCGYCQSGMLMAAAALLDKNPRPSDA
DIDAAMTNLCRCGTYQRVRAAIHRAAAAMKKGGAA
>A0A238JTT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actibacterium lipolyticum|TrEMBL
MTIELSINGKTRSVEAAPGTPLLWVIRDELNLTGTKFGCGVASCGACTVHMDGTPVRSCQ
TYIEDVEGAEITTIEAIEGKAAAAVQAAWRELDVVQCGYCQSGQIMQAVGLLTETPKPTD
EDIDGYMAGNACRCATYQRIRAAIHVAAEKMEA
>A0A7X0JT31|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoteredinibacter isoporae|TrEMBL
MSKHSIQEISQLNRRQFLQATGIAGSGLLLGAPLAQAAPKAVPMDLISGADSSAEDFLRL
NLFVELALDGTVRIVCHRSEMGQGIRTGLPQVLADEMGADWNKVQVIQGQANKEYGSQNT
DGSRSVRNFYLPMRKMGAAAREMLRQAAAKKWGVSVDRISVDKHQLSDGKRSASFAELAS
LAAQEALPNLDKLKLKAKKDFNYIGKPVSGVDMPEFIQGKATFGVDVQLPDMVHASIERS
PVMGGKLISVDDKEALAVAGVLAVEKIQGKPLPAAFNALEGVAVIASNTWAAQQGRKKLK
LQWDLGANKTHGSKEYDQILAASHEKDEGSLHLYEQGDVKAAFAKAAHLVEGNYHVPYLA
HASMEPPAASAIYKDGRCEVWACTQTPQSAQRQVAASLGINPEQVTVHVTYLGGGFGRKS
KPDFVAEAALLAKQLGKPVKVTWSREDDIRHDYLHAVCDTQLKASVDKGGNITAWQGSAA
FPSIGSTFGPADSMAGWELDQGFHDFPFDVPNVALKRRKINAHMRIGWLRSVINIPMAFA
NGSLMGELAAAANMDAKEFWLKSLGPDRNIKPRVDSYSNYGNKIEQYPYETARAKAVIER
VCKNAKWDAPREKGVGFGLAYHYSFLAHVAVVAKVAWDGNTPKLLALYSVIDAGQVVNPD
RVKSQMEGAMIFGTSIAMYSEITTLNGQVEQGNFDGYRLTRMNESPDIHTEIVEADDAPR
GVGEPGVPPVAPAIVNALANAGGPRIRKLPIANHLTV
>A0A840YR95|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas xinjiangensis|TrEMBL
MAPDHGTSGRIDRRTLLIGGGLGAGLLVAWAAWPRTYLPNLTAAQGETLFGAWIKIGTDG
HVTVAVPQLEEGQGVYTALPQIVADELGAEWKMVGVEPAPLNPLYANPLAAETLFEAAFA
RVPASLRRSYATRNALVLTGASTSIRTFEDQLRQAGAAARVLLQKAAARRWGADWQTLTT
SRSFVVNGTQKLGFGALAADAVGESLPDLLPLRVGEDRLTGRAVPRLDVPAKVDGTALFA
ADIRLPDMLHASIRMGPAGDTALVKLDRAAADRIPGMRAVVTAENWVAAAADHWWAADRA
LDAMRPRFRAPAQVVNTDSIEDALSSALDGAGTRIAQGGDLAATFRGARLITAEYRVGLA
LHATLEPMTCTAQWKDGRLRLWLPAQAPVLARAAAAHEIDVDQNVVTVHPTLAGGSFGAK
LEVEIARQAARLAKDLGRPVQLTWPRGEDFRHDRYRPAAAGRMAAKLDAANRITGWLAKI
AAPETSRELSERLLEGQLLAAASLKLHSGDPAAAAGAVPPYAIPNIAVDHHVAAIGVPTG
YWRSGAHSYTCFFTESFLDELAHVAGQEAVSFRMGMLGQQPRLARCLQMAAQLGGWQGGQ
PGSGQGIACHSFRGSHIAVMAEAHLASDRRVKVDRLVAAVDCGRVVNPDLVTQQIEGGLI
FGVAAATGCSTGFSENVADIGDFSELRLPTLADAPEITVEIVPSVENAGGVSELGVPPVA
PAIANALQAATGVRFRRLPLLSDVE
>A0A5P9HE32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas sp. THAF12|TrEMBL
MTTLTINGQTHEVDAPADMPLLWAIRDLVGFTGTKYGCGRGLCGACTVHLDGQATRSCIT
PIAAVGDREITTIEAIGDDPTGASVQKAWRELDVVQCGYCQSGQIMSATALLQGNPEPDD
SAIDGAMSGNLCRCATYVRIRAAIHEAAASLGQEVS
>Q0K114|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)|TrEMBL
MSECHTSRRRFLQAASAVPAAFVLGFHLPLAKAADAPAHDPDDINAWLRIDADGSVTIMV
PSAELGQGVMTSAPMLIAEELECDWKQVRAELAPTDPVYNNRMFKVQATASSTSARWSFE
PLRRIGATAREMLREAAAQGWKVPVAECRAVQGVVRHEASGRTLGYGALAARAAALPRPA
SVALKDPRDWKLLGRPTDRLDIPLKTRGAAVFGVDVKVPRMLVGSVMACPAFGGKLHRVE
ARPALAVRGVRRVVPLDDAVVVLADSYWTARKGLAALRPDWKLPQGEPVGDAALMAGYRE
AARSASALALRNGDPDAHMQAGQAYTAEYEVPYLAHATMEPMNATADVRADRAEIWGPTQ
VCGEIAHRLAPVLGLPAERIVVHSTFVGGGFGRREEFDVFLQAALASKAAGQPVKLIWSR
EEDIQHDFYRPAAAARFSAVLAPGAAGIRALDARLACSSIYIRNFPDRVKGGVDPKSVEG
VVDLPYALPNVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHARTDPLQFRLR
LLAERPRQADLLRRLAQQAGWGGAPAGRFQGVALSQAWGSLCATVVELSVRDKRITLHRI
VNAIDCGTVINPATVERQLEGASIWGLSAALSGVITIGDGRVQQSNFHDYPLLRLAQTPR
FEAVLVQSGERIGGVGESAVPTLAPALANALFAATGERIRSLPLARHGFELA
>A0A2C9D934|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hartmannibacter diazotrophicus|TrEMBL
MFRLKINGSIHDVDVEADTPLLWVLRDTIGLTGTKYGCGIAQCGACTVMIDGDATRSCQM
PVEAIGDAEIVTIDAIEADEVGRKVVEAWVSVQVPQCGYCQSGQVMAATALLKSNPKPAD
EDIADAMTNLCRCGTYNRIADAVRQAAG
>H0SRK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MNQHVKAAPTMATDLSRRSFLVGTAATGLVLGYAGLADSALAATTPSAFEPSVWYSIAPD
GLVTVTCGKADMGQHIASTMAQIVCEELGAAWKDMRVQLASNDPKFNDPVLGAQITGGSW
STMMNFDAMSRAGAAGRIALTEAAATAMGVPAKELVVRDGVVMHPKSKKQMSYAEIVKSG
KITKSFTPDELKAITLKTPDQYTMIGVSVPQIDIPSKTNGTAKYGIDTMLPGMVYGKVVT
PPVRFGATVKSVDDSEAKKVPGFIKAVVLDDKTGSTSGWVVAVASTFANAKKAADALKIS
YDKGPYANVSTDTIITEAMRLQAQDDSGQFFVKDGDANAALAGAVKVLEAEYTTSINIHA
PMEPMNATAEFKGDILHIYSGNQFATRSGAIAAGAAGIDPKYVVMHQAWLGGGFGRRLDA
DMMVPAVQAAKAVGKPVKVIYSRENDMTMDYSRPLTYQKVKAGLDASGKLIALSHDVVSA
WPTARWGIPDFLSPSVDKKGPLDSFTVNGADFFYTVPNHHVRAIKNELAHNATPSGQLRS
VAPGWTFWAVESMIDEIAAAAGQDPAQFRIALLDGKGKNDGGAQRLRNTLLAAMGLSGYG
AKKLPKGEGMGVACVSSQERATASWTACVAHVAVADSGAVTVKKLTVATDVGTQVHPDNI
RAQVEGAALWGLSLAMYEKATMKDGGIEQTNFDSYTPLRMSQVPEVAIAVIANGEKATGV
GEPAVTVVAPALGNAIYNACGARLRSLPITAQAVKAAMKA
>C7C6L3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)|TrEMBL
MNDLTPHHRLGIAARPASEPVRNLSRRGFLGIVSGALLLGIDLSKDAAAQTRAEGPAAVA
AKPGTRVAAFLEIRRDGDVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFTVECAPPGP
DYAVVNGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAARLAVPQDSLTTEDGRVIHA
ASGRTLGYGEVAQAALALLPRDDVALKNSKDFRWIGRPVARLDMRDKATGRATYAIDIRL
DAMLHAAVQHAPHLGTEPRAVANEAEVRAMPGVHSVHRLPGAVAVLADSWWRARKGAEAL
RVTWSEPAPEGIATVSATFSSAAMLAALKDTTEPGLPAEQEGDPGAAFANAAKVIEAEYD
APYLAHAQLEPPSAVARFTADGSLDLWVPNQMPELFQQIAAKTAELEPEQVRIHSPMLGG
FFGRHFSYGPANPFPQAILLAKATGQPVRVLWSREEEFGMDAVRPLSFARFRAALGPDGM
PVALQTTAVGEGPISRWFGALFTSPVDSSVVEGLDKKPYAIPNRRLDYVRVAHPVTIAFW
RSVGHSMNDYFYESFLDEIAEAGGRDPFDLRMALLTNSPRHATLLRRVAELAGGWRRGPF
VAEDGTRRARGVSMASPFGSETATIAEVSLEDGEARVHDLWIAIDPGSVVNPAIVRRQVE
SAAALGLSSTLLEQVVYENGQRQARNFDTYPILDRTRMPRVHVAIVESGAPMGGIGEPGL
PGVPPAVVNAVAVLTRQRVRSLPLAKTRLSGV
>A0A375EN06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLDVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVKAVVGHAVTTLEGLGRAQHPDPVQQAFIEEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQAAQGAAS
>A0A7Z7NQD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVDAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGTVARADITTIEGLSVDNSHPVQRAWIAEQVPQCGYCQPGMIMAACAFLKDNPMPRP
EDVRAGITNLCRCGTYPRVERAILRAATALNNGDPKGRASS
>A0A375BY14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNAPRPLTLQVNHAEHTLEVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVRAAVGHAVTTLEGLGTAQHPDPVQQAFIEEQAAQCGYCLNGMIMTAKALLAQN
PDPDETQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQAAQGAAS
>A0A7W7B3R5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingosinicella soli|TrEMBL
MTRFTINGNPVAFDLPPETPLLWALRDAMNLTGTKFGCGAGLCGACTVHIDGQAQRSCQV
NIGDIEGTFVTTIEGLSRDGSHPVQQAWIAEQVPQCGYCQPGMIMAAAAFLKDTPKPTED
DIKAGITNLCRCGTYPRIKKAILRAAGTPKEG
>A0A4P8HZC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MAQSTRRRFLLAGAAAAGALVVGWGALPPRQRLNTAVPLALDGGAVALNGWVALAADNTV
TVVVPRAEMGQGVHTALPMLVAEELDMPLARVRIAAAPPDKIYANIAAIRDALPFHPDDT
GNTQAFARWTLAKVARELGISLTGGSTSVKDAWLPMREAGAAARGMLVAAAARAWGVAPD
GIRTADGELFHDASGRRATYGSFAAAAASENPGDAILKEPHAFRLIGRAVPRRDARTRVD
GTARFGIDARPEGMVYAALRMAPALGATIAGTNAAGVLRLPGVLSVIDISNAFSWRLAGH
DGAPAGVAVVARTFWQAKTAAEAHAIRWDAGPHAELSSDGIHDDLRAALDGTEHHVYFAQ
GDVADAQAHGRTIDAEYSAPFLAHAAMEPVNCTAQVADGKVRLWLSTQAPSIAIGIAAAV
AGVDREQVELHEHLLGGGFGRRLEGDMVAQAVAIARECRGLPVQMIWTREQDLRHDAYRP
AAVARLAATLDAAGTIKSWDFIGAGGALTDHFLRRNLGLPGAGPDKTTVEGAYDMQYAIP
HQRIAHAAVASAVPLGNWRSVGHSFNAFFKESFIDEVAHAAGKDPVAFRRAMLLGHPRHV
AVLDAAVRAAGTPPAGRAHGVALHHSFGAIVAQVAEVSVHDGAIRVHRVVCAIDCGLAVN
PGHVAQQMESAVAFGLTAALEGAITVAGGAVQQSNFGDYPVLRMGQVPHVDTVIVLSGEP
PEGVGEPGVPPVAPAVANAVFRLTGQRLRSLPLRLA
>A0A3G7YA90|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R5-89-07|TrEMBL
MRSPAQNVNLSRRTFMINGALVMGFAMLPGIPRAFADTEVDTLGTVILAPDLPGSLRATP
YLDAWIRIDAKDGISVYTGKVELGTGVKTALLQIAAERLEVSPGLIRFLTADTALTPNEG
YTAGSHTIVDSGTALFNAAAQVRQLLLESAARQWQHGIESLTTRDAVIYDAQGRSMTYAQ
AVVGVQLHRFASTSSPFKPASSFTLIGKSLPRLDIPAKVSGGAAYVQDMRLPDMLHARVI
RPPRRGSQLLEIDEAALKNLPGDVKLIRNGSYLAVVATDEWLAIKAMREGYATARWTAGN
ALPDSTHIHQLLTQLPSRHYPVAAKGAPPQPGPPAYKARVTKQYLMHGSIGPSCAVAWFK
DGTLTVWTHTQGVYPLRMGIAEMVGLPVAQVRCIHAEGSGCYGHNGADDAAADAALIAMA
IPGKPIRVQWMREQENLWEPYSSAMLAEVEAGLDDSGRLRDWKYELWSTPHNERIVNAGR
LLPAWLLAKPFTPAPSVPIAQPEGDGDRNAVPLYEIPNLKVDLNFVLTMPFRTSAMRSLG
AHINVFAIESSVDELAARGTIDPVQFRLNHLSDPRARAVVERVAAEFRWPHKATGPGSGI
GFAFARYKNIMGYCAIAVQLHVQRQTGQVTIDRVVAAVDVGQIVSPDGLLNQIQGGIVQS
ASWTLYERILYDANGMYSFDWSGYPIMRFVDVPQQVEVHMIDQPDQPFLGAAEIVQGPMA
AALGNAINDATGKRLLDLPLARRGWQDALGA
>A0A3G7YFM4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R5-89-07|TrEMBL
MSRLPADFVLTNLSRRGFLKGAGATGALVIAASWGLPDAFAADAVKPYGGDAMPNGLIDD
PKVYVSIATDGTVTVMCNRSEMGQGVRTSLSLVVADELEADWAKVKVQQAPGDEVRYGNQ
DTDGSRSMRHWYEPMRRCGASVRAMLEQAAAEQWKVPVSECRAQLHKVTHQPSGRELGYG
ELATAAGALAVPARDSLRLKQPAEFRYIGKEGVKAIDGVDIVNGTAVYGADVHLDGMLYA
TIARPKVYGGKVKSFDASAALKVPGVIKVLEIESRPIPSEFQPLGGVAVVASNTWAALKG
RDALNIVWDDGVNASYNSVDYRRELEAAARQPGKVVRNTGTLDQAMGEADSTLEAAYYLP
HLAQSPMEPMVAVARFDKGQCEAWAPSQAPQVTRERIAERLGLPFDNVTVHVTLLGGGFG
RKSKPDFVIEAAVLAKQFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGLNKDGLPAAWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEASAHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLQYQIKLLGPDRQIDPKTLSDEWNYGESPERYPIDTARL
RGVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPRQIAVHL
VTPAGEVPLGGVGEPGVPPIAPALCNAIFAATGQRIRSLPIRYQLQGWQEAKA
>A0A1R3V3C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium prunaredense|TrEMBL
MRLTVDGQAFDFDADPEMPLLWALRDLMGKTGPKFGCGIAACGACTVHVDGQPVRSCSLP
VGEVTGAVTTIEGIGTEGRLHPVQQAWLEEQVAQCGYCQAGQIMSAVALLDEVAEPTDAD
IDDAMGGNLCRCGTYPKIRAAIRRAVVLKTAGI
>A0A846UPG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. SG609|TrEMBL
MSAQPSRLPIDAPPAAVPDETAPERCTMRLSVNGQARTINADPDTPLLRVLRQDLGLTGA
CFACTNGRCSACTVHVDDRPTRACRVPVHVVQGAQIVTIEGLAAREGLPPGQLHAVQRAW
AECGVPPCPCQAGMIMAATALLMDNPDPGTAEIEAALFLDCGCGARPHVLRAVRSLAERL
RSW
>A0A1L5NSA0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium gallicum|TrEMBL
MTHILQPQSRALSRRSFLVTVGGLGIAVAFGKPPGLAYGADMAPSAQGDFRPNAWVTIAA
DGTVSIISPAVEMGQGITTTLPLLVAEELDADWNRVRVVQAPSDAETYGNPGFYGIQLTG
GSESTRGYNALLRLTGAQTRLVLLAGAAGMLNVPVKELETEPHKVVHPPSGRSLDYGEIA
TKALLPDPLPQATEADLKPSDRWRYIGSRTVQRIDVPSKVNGTAAFGIDVQLPEMLFGAV
LRAPVQDERPETIDDAEARDVPGITHIVPLPYGVGIIGETVEATRRAKDLLKVTWSTTSR
VRNYTSQRLLDEYRAVGRALGQQGVPAHTNGDAEAAIAGAATVIAVDYMSDHVAHATMEP
MNATALVTGDRVEIWAPTQGPTGTQGFAAEVVGTTPDKVKVNTTLIGGGFGRKAEADFIV
DAVSLAKAVEGRPVKVIWSREDDVRHDKFRPLEAQHVRVGLDAEGNIVGWRHRIVADSIF
ARTLPPVFAEAGGHDDVVTEGAKFNYTVPAHQIEYLRQDNGLAIGFWFAVGVGYTRFAIE
CVVDEIAAARGVDPVALRLELLKDQPRARRVIETVARMAEWDRARDGRGLGMAYSDAFGS
HCAQVAEVSLNRETGAIRVHKVWCAIDPGVAIQPLHVEAMMMTGITNGTGHALFEQINVI
EGEVQESNFDTYRVIRMSEAPEIEVAVVPTPGSPFGGIGQAGLPPTGPAIANAVARLTGG
VRLRHYPFTQERVKAALEA
>A0A7R8QFF8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylacidimicrobium sp. AP8|TrEMBL
MGAGRSSHPMHLVINEKSYSVDAPEDLKLVWVLREHLHLTGTKFGCGIGACGACTVHLDG
KAVRSCQIPLGSVQGKITTIEGLPEDHPVKRAWIRHQVPQCGYCQPGQIMQAAALLSARP
HPGTEEILAAMNGNLCRCGTYPRILRAIQELAGAST
>A0A7W5QQJ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. BK369|TrEMBL
MTEWTPLDPALAKVLPTGEPVNVSRRGFLGGASAGALVIGFGLPVGAARAQAAGAAPAVV
PGTRVPAFLAINPDGTIRLQSPFAEGGQGVWTAMAQIVGEELDADPATFVVENAPTGPDY
QVINGKMRITGGSMSVRSSYDTMRRLGASARAMLIQAAAQRLSVPASALSTQPGRVVHQA
SGRSLSYAELAPHALDLPAPTTPPALKDPKDFRWIGKPQARLDVRAKSTGKAQFAIDSKV
DGMLHAAVQHAPRLGMTVGEIRNEAAVKAMKGVHSVHVLDGAVAVVALRFWHARRAVEAA
QVDWVEPTGASYRPMPATFSTADHAAHLATVQGTQEVAETAGDVAKAFAEAGAKGTLSAT
YHSQYLNHAQLEPPSALARFNADGTLDMWFPNQAPDMFLAEVAKVSGLPPEKIRIHSPLL
GGFFGRHFLYPKGNPYPQAIELAKRVNAPVKLIWTREEEFLRDPLRPMAAVRFHGAVDAN
GMPLAVEAVSATEGPREGIADKRSGEIDPTALEGLAGKSYALPNKRIAQIFVKSPTTVAY
WRSVGNSMNDFFYEAFLDELADKGGQDPYAVRLHLLSGNARLTTLLKAVVDLSGGWKRGP
FTAPDGTTRARGMAMASPFGTQTAAIAEVSIADGQVKVHDVWQAIDPGSIVNPAIITAQV
NSAVALGLSQALIEEAAYKNGERVARNFDGYPILTPDRMPRVHVRIVESGEKMGGIGEPG
LPAVPPAVANAVSRLRGQRVRTLPIGTLS
>A0A6L5C4N3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas frederiksbergensis|TrEMBL
MSVLNINGRDYTVDVDPGTPILWTLRDALGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIVAAQGRKITTIEAATNGSDPVGTAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTAAEIDSAMAGNICRCGTYVRIRAAVADAAKALA
>A0A6L5C2B4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas frederiksbergensis|TrEMBL
MLNDLFPDELPRVLQHMLEREHGDGPATLPRRSFLKIVGIGGLALGAFPHLALAQQTNGA
AVEPLKPTQQPNAFVQIAPNGEVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
TSDIAYQDPRFGMHLTGGSNSIKNSYTQYRELGARARAMLLAAAAARWNVDVATLSTQAG
TVLGPAGRKASYGELAEAAMALPVPEQVTLKDAKDFRIIGQATTRIDAKAKSSGQQDFGI
DMHLPAQLTAVVARPPVFGAKIASLDDSAARAIKGVKAVLRVPLDGGAEGVAVIADGYWQ
AKQGRDALKLEWNTSAVEKVDSEKQLADYKALAGRPGPHHFEADMAPLATAPHTLDAEFV
FPYLAHAPMEPLNCTVQLSEGRAELWVGTQFAGADNAAAARVLSLKPDQVQINVQTAGGG
FGRRGIATCDIVVLACEVAKAARTAGLNVPVRTLWSREDDIKGGYYRPMHLHRARIGFDD
SGKVLAWDHVLVGQSIVTGTMFGGRVKNGIDPTATEGMRDPYPMPMRLTVHHPKLNVPVL
WWRSVGSTHTAFVMETLIDEIARATKQDPVAYRMKLFADKSPRHIAALQLAVDKSGYGKR
QLPDGRAWGVAVHESFSSVVAYVVEASVQNGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
ALMGLSMCLPGGAITLKDGVVQQSNFADYSVPRITDMPEFSIHVVPSAEPPTGMGEPGLP
PLAPAFANAIARITGKPLRELPFKLA
>A0A6L5BRC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas frederiksbergensis|TrEMBL
MSQLPNDFALSNLSNLSRRGFLKGVGATSALVIAASWGWQDAFAEDKPKKFGADGMPNGW
VDDPKVYVSIAADGTVTVVCNRSEMGQGVRTSLSMVVADELDADWALVKVQQAPGDEVRF
GNQDTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVVECRAQLHKVIHQPTKREL
GYGELAAAASALAVPARDSLRLKQPSEFRYIGKEGVRAIDGADIVNGRAVYGADVHFDGM
LYATIARPAVYGGKVKSFDANAAMKVPGVIKVLQIESRPLPSEFQPLGGVAVVASNTWAA
IKGREALNIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALAGAGSTLEASY
YLPHLAQAPMEPMVAIARFKDGVCEAWAPSQAPQVTRERIGERLGLPFDNVTFNVTLLGG
GFGRKSKPDFVIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLDKDGLPS
GWLHRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSV
SNIPHGFAIQTFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDT
ARMRTVLETAAKAAGWGRTLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIA
VDCGPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVA
VHLVTPPGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRSLPVRYQLQGWQKAQA
>A0A0P1ICU2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria denitrificans|TrEMBL
MTINTSRRGFLKGAAAAGAVLLVGARPDGALAVASSETTQFNPFVKIDADGTVTAIVKHF
EKGQGPATGLPTLIAEEIGLRMDQIEYEFAPSNPQVYNNLLFGPFQGTGGSTAMANSWMQ
YRQAGAAAREMLIAAAAQNWGVDAAGITIEEGIVKAGNQSAPIADFVAAASQLDAPAEPR
LKDPSEFRLIGNESVRRKDSAIKGNGQAMYAMDVHLANQMVTMIKRPESKGGIANGFDDS
ASKEIKGYISAAVLPNQAGVAVYAENTWAAIQARDALEVDWDMSGAETRHSDQIKAEIMA
ALDAEPAYNVNKAEVAAVAAAIDEADKVIEKTFYFPLLAHAPMEPLNCTIEQTAEGDIVL
HDGAQMPTGPHMAYQQIFQLPPEKIHIKTMLAGGSFGRRATPDADYQVEAALAFVVTDRS
RPVKLVWTREDDIRSGYYRPAFGHKVRVGLDADGNIVGWQHQVAGQSVIKGTPFESVLVH
DGIDHSSIEGIADSPYAIPGMALGLTDTPKATTVLWWRSVGHTHTAYTMETMMDLVAEAA
GRDPVEFRLAHLSDSSNADQIRKAAVLKLAAEKAGWGNAPAGRAQGIAVHKSFGSYAAEV
VEVSGDPEDGIKIEKVTCAIDCGIAVNPDVVRAQMEGGVGYGIGHVMRDQITLTDGTVDQ
FNFPDYEPLRIGDIAAIDVHIVPSAEAPTGVGEPGTPPSAPALANAINALSGTHVAELPM
AENGISFV
>A0A811H4Q9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter mucicolens|TrEMBL
MTQLQINGQAQDVDVPDDMPILWVLRDELGMTGTKFGCGMALCGACTVHIDGTPVRACLT
PVSVASGRQLSTIEGMDADPVGRAVQTAWVDNNVAQCGYCQAGQIMTAVSLLKANPNPNE
QEIADAMSGNICRCGTYPRILAAIQQAANRLAQGGKQ
>A0A840B0G2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus rigui|TrEMBL
MKRSLGRELIFMAIQTSINGKPVALAAEPDTPLLWVIREELGLTGTKFGCGIAACGACTV
HVNGEPTRSCSLPVSEVAGKSITTIEGLKSADGTLHAVQQAWISAQVPQCGYCQSGQIMA
AVALIEKTGSPSDAQIDEAMTNICRCGTYPRIRKAIHAATGQAAKAAKPVEGGA
>A0A6T9Y234|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alteromonas macleodii|TrEMBL
MITMIEFTLNGKTVQTDAASDTPLVWVIRDEFGLKGTKFGCGVAMCGVCTVHIDGNAIRS
CSYPVSLVNGKKVNTIESLNGEHPLQAAWVEEQVPQCGYCQSGQIMQAATLLDSNPNPSD
QDIVNHMNGNYCRCMAYTRIKKAIKRAATSTVQHYDPKASSEGENA
>A0A840U111|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhabdobacter roseus|TrEMBL
MAAISLTINGQLQRLDVDPRTPLLWVLRDQVGLKGTKFGCGISQCGACTVHIDGKPARSC
SYPVQAAADKQITTIEGIGTEEKLHPVQRAWIEEQVPQCGYCQSGQIMTAVALLKDKPAP
TDEDIDLAMRGNLCRCGTYQRVRKAIHSAAANSKGDGITQGK
>A0A1S1HHW7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas haloaromaticamans|TrEMBL
MPDIAIERRSFLKATLLTGGALAIDARVALAGTAGEAPVALNAFIRIAADNSITIGAKNP
EIGQGVKTMLPMLIAEELDVDWAQVRIEQTHAAEKLFGPQVAGGSRATPVNWLPMRRVGA
TARSLLVQAAARKWGVDPAGLATAGGVVTHEASGRTARYADLAAEAAALPPIDPENVKLK
DPAAFRIIGTSIGGVDVPAIVAGKPLYGIDVAMPGLLHAALEVCPVFGGTFRAGNLDEVR
KMPGVRHVIVIKGNGQAESLYDGVAVLAESWWVADRARQALDLQWDTAGLEGFSTDGYAA
EAAARMGAKPDAELARHGDVEAAFAAAARVVRADYSYPFLAHGTLEPQNCTALVKDGKVE
IWAPTQNPEPGRKLVAEALGVPPEAIRINMTRSGGGFGRRLMNDYMVRAAAIAAQVPGTP
VKLLYARTDDVRRDFYRPGGWHRFAAAIDGRGRLTGFTDHFITFGQDGKPIRSAQMSPFE
FPAGCVPNLAYGQSLLATNLPTGWLRAPGSNALGFVFQSFLDEVAVAAGKTLPDLMIELL
GEPRDLPWLPNAPALNTGRARGVIDKVCAMAGWGKGARLPEGRGRGFGFYFSHMGYFAEI
VDVAVSAEGEARVAKVWVAGDVGSQIVNPVNAINQVQGSVIEGLGYALSGQAITQVAGAV
TQENFHDAPIPRIGEVPEIVVEWVITDNPPSGLGEPALPPVIPALANAIHAATGKRIRSL
PITAEMLAG
>A0A1S1HIF1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas haloaromaticamans|TrEMBL
MTRFTVNGQPVHYRMDPETPLLWALRDASNLTGTKYGCGAGLCGACTVHLDGAAVRSCQV
PIGSIEGSFVTTIEALSRDRSHPVQQAWVAESVPQCGYCQSGIIMAVAAMLEKNPNPSDA
DIDAEITNICRCGTYPRIRRAIRHAARVAAGGETIAAAPPPGIDPEDAARAIPALTPPKP
AGKE
>A0A653RPA5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. 9I|TrEMBL
MVTLNINGRDLQVDADPSTPILWALRDNLNMTGTKFGCGAALCGACTVHLDGNPIRSCVT
PISSVQGQKITTIEAMENDKVGKAVQDAWVKHDVPQCGYCQSGQVMSAAALLRTNKRPSD
ADIDNAMSGNICRCGTYQRIRAAIKDAAKTLA
>A0A445NES7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces netropsis|TrEMBL
MPSHTFTVNGRSVTVDAPDDLPLLWALRDLLGIRGPKYGCGIDVCKACTSHLDGEAVRPC
VVPVSEAAGRDVTTIEGLADGDTLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKRTKNP
TDADIDAIANVCRCGTYFRIREAIHSAAAKMR
>A0A7W6XMA4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium esperanzae|TrEMBL
MYQLNVNGRDVQVDADADTPLLWVLRDELGLTGTKFGCGMAQCGACTVHLDGTATRCCVL
PVESVVGSKIETIESISANGPHILQRLWIEHQVPQCGYCQSGMIMAATALLAENPKPTED
DIDTAMTNICRCGTYPRVKAAILAAASEASK
>A0A0A1HS31|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. SHC52|TrEMBL
MSALNINGREYTVDVDPGTPILWTLRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGKKITTIEAATDGSDPVGTAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTAAEIDSAMAGNICRCGTYVRIRAAVADAAKALA
>A0A839Z4K7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomicrobium lutaoense|TrEMBL
MKLPEVDRRGLLIGGGVGAGLIVAIALWPRRPSVPHGMAGDEARFDHYLRIDREGRVTAA
LPQVETGQGIWTTLAGVIAAELGADPQEVAIEPALPAPGLENEVLAEEFGGSGLQVTAGA
SSIRAFEGPVRSAAATARTALLREASRRLDVPVVELRAERGAVRHGQRSVPFAELVEDAA
GRALPRPDSAAPNLAKLENLRRFDGPAKAQGSWRFAADVRLPGMVHAAARLAPPFGSISA
IDRARATERETTLALIERPQWVAALADTSWEAEQAIIAADIRVRSPGIDEKGVAARMQRA
MERGTMRTLVDKGDADDIVDGSDARLGGEFSAHPFLHDTLEAVAACARLGSDGVMQVWSG
SQAPGATRRRVAIATGLSEDKVMLIPLPAGGPDGRMLEDEAAPIAAIVAMESRKPVSLRL
SHAHAARMDSVGPPMLARIEAVPSPEGRIAAWRARYVGAGGLGAAMARLAGKEHGEPDQV
ALVPPYGIPELKVAMAKADLPIRTGYRRGHAAMLHNFAVESTIDEVARAIGAEPLAFRIS
MLGGNVRLARLVQKVGQRARWNSTSMGLALASLDGSAIALIAEAEEGVDAPIVTRLVAAV
DCGRAIYPDMVRRQVEAGLIANLQSLLQPPPSYRAAMPLARAPARPPALPDIDVMLVDQG
IGEAGGVSSLASAVLAPAIANALVARGSKRLRALPFTRQGMAR
>A0A1V1W4Q6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides sp. PD653|TrEMBL
MTPDLDATTAAPGIGRRSFIGYVLGGTTLVAAADLVGAGVPAAAVPGTPQPAESYDLNDF
LTEAAMPTANLITVTVHEDGTASFALPRMEVGQGITTSTAMLIAEELELPVDRVRVTLAD
ARPELLYNQLTGGSNTTISTYTPIRVAAAVAKGALLEAAAIQLGDTVDNLRAKGGVVQAP
DGSSVTYGELARAAAGSTTRAMEVRLKEPGEFRVVGVGQPRIDALDAVTGRKLYATDLQV
KGALPTMVCRAPTLNGTPKRLRNKAAVLAMPGVRNVAVVDSGVAVRAETFGQCIDAIRAM
KVDWVDGPVAGLSDADIVDELRAAELPLPTLPDNPLAKTVDLDVLFYFRSNSAMDTNSAI
ADVRPDRATVWAGLKSPITAQQKIAEALGLSQDAVKVHVVQGGGSFGRRLFFDGALEAAK
ISQAMGKPVKLMWHRADDARVGRGHPMATSRVRAVHANGEVLAFQQSHTSIETDFRHGLG
EIITANSADLPGGLGNLGFAETVFELTQEVPYDFGVITQTLTETDDRFNTGSMRNIYSPD
VRVAGELMVDRLAAAMGQDPYEFRRAHLRNDRVRAVLDTVADVGDWGRSMPAGTAQGIAI
HKEYKGCSACLVEIDNRPQQTGRDIRDGVGGPRVTKVVFAIDVGLVVNPRGLEAQMQGCI
NDGIALALTSSMHLRDGHFLEASWDNYFYTRQWNTPPDVEVVVMASDSAQPGGAGEAGVA
ATFAAVACAFARAAGSVPTYFPVNHRDPLEFTPKPFVPPIPQSPTNGLKLTY
>S5SVJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli bv. mimosae str. Mim1|TrEMBL
MRTLKINNVFHKVDVPDDMPLLWVLRDVLGMTGTKYGCGIAQCGACTVHLDGEAVRACQT
TMEMIANQAITTIEGIGATETGAKVQAAWLEKEVVQCGYCQCGQIMAATALLNENPKPSD
NDIDDFMAGNMCRCATYVRIRDAIHTAAA
>A0A840A0H2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phenylobacterium haematophilum|TrEMBL
MAMTLDVNGKPLAVKAAPDTPLLWVLRDELQLTGTKYGCGVAQCGACTVMVDGQAVRSCV
TPIEAVAAGKITTIEGLGGQHPLQQAWVKHEVPQCGYCQAGQIMSAVALLSANAKPTDAD
IDAAMDGNICRCGTYQRVRAAIKDAATMPANAPAAAPAPAKA
>A0A5P9FL60|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax sp. THAF30|TrEMBL
MKLTVNGTSHEVDVEEDMPLLWVLRDELGYKGVKYGCGIAQCGACTVHLDGVATRSCQIP
AGSAEGAEVLTIEGLGQPDALHALQAAWIEHQVAQCGYCQSGQIMQAADLLSQVADPTDQ
DIDDAMGGNLCRCGTYPRIRAAIRSAAQAMKEV
>A5EEJ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MSAGTPTETDAPRGWLVVERPVAGADGQFETFIRITASGEVSAFNGHVDLGTGIRTALGQ
IVAEELDVSFARVVVVLGDTAIVPNQGATIASETIQITAVPLRKAAAQARAFLLVRAAAQ
LGAAIEDLAVEDGLVRGANNRALSYGELIGDETIRLALADDVAVKPVDNYQVVGRSVPRV
DLPAKATGELTYVHDVRVPGMLHGRVVRPPYAGIDAGPFIGTSLIGVDKDSVRDVPGLVD
VVVIGDFVGVVAEREEHAILAAERLQVSWKPVPDLRNLDDVANALRANPSSPRRLLDKGD
VDAAIAGAAKPMRRTYLWPYQMHGSIGPSCAVADVRDGQIRIYSGTQNPHILRADLAKLI
DCPEHQIELIRLEAAGCYGRNCADDVTADALLLSRAVGRPVRVQLTREQEHLWEPKGTAQ
LMDVNGGLNADGSVAAYEFATRYPSNGAPTLALLLTGRVAPEPVVFEMGDRTAIPPYDYD
HMRVTAHDMPPIVRASWLRGVSALPNTFAHESYIDELAAEAEVDPIEYRLRYLKDERARD
LVNAVAERAGWTPRPVRQEKTPVDGVVHGRGFAYALYVHSKFPGYGAAWSAWIADVAVDT
TTGDVSVTRVVAGQDSGLMINPDGVRHQIEGNVIQSTSRALMEEVPFTRGKVAAREWGAY
PIITFPDVPDIDVLMLPRPDQPPLGVGESASVPSAAAIANAIYDATGVRFREPPFTPERI
LEGLRGEQAERPSPPHLPTPDKPAKTWLKPFAKQGGLIAGAVAACAAAIGVAAAVLPWRA
IAPIAPSDPAVYSAATIARGEALAALGNCAVCHTADGGLTNAGGRALETPFGTLFSTNIT
PDLDTGIGAWSYPAFERAMREGVHRDGRQLYPAFPYTHFARTSDADLQALYAYLMAQPPV
RQQAPDNQLRFPFNLRPLVAGWNALFHDNQPFKSDPTKSEQWNRGFYLVESLGHCSACHS
PRNALGAEQRKAYLAGGFADGWEAPALTSLSSAPIPWTEDELYTYLRSGQSRFHGVAAGP
MAPIVKDLATLADADIRAMATYLASFQEAAPEPATLEAMAAELEALTQVTSASSPAARLY
LGACAVCHEVGGLPLFGSRPSLALNSNLHSATPDNLIQVILHGIMKPASSDLGYMPAFRD
HLSDTQLAELVSYLRGQFAPDKPGWTNVEAAVSRIRSATPH
>A0A7X0D148|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium wenxiniae|TrEMBL
MKQVTINGNVHDIDVPDDMPLLWVLRDVLGMTGTKYGCGIAQCGACTVHLDGVAVRSCQT
TMDSVYGQPVTTIEGVGDTPVGAKVQAAWLEKEVVQCGYCQSGQIMSAAALLNENSNPTD
TDIDDAMAGNICRCGTYVRIREAIHSIAV
>R7ZSV9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lunatimonas lonarensis|TrEMBL
MANYNLQINGKSYQVDVDEDTPLLWVLRDHLGLVGTKYSCGISQCGACTVHINDSAVKSC
NYPVSAVGSEKVVTIEGLSKDGDHPVQQAWGEVDVAQCGYCQAGQIMTAVAFLKKNPTPT
ESELVEAMNGNICRCGTYHRIKEAVLLAASKTKKS
>A0A654B3N4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas titanicae|TrEMBL
MKTHHLSFSRRAFLGGTLVAGAALIIPLRLPTAWAREEEDSLFSHAYIRIDTNGQVTFLL
PTSEMGQGTHTGQAQILAEELGADWSSITVGMPNQLSDDYRIPFIGQMRSVGSFGIRFWH
GPLRRAAAQARQMLTQAAAERLDVAAAALHAENGFIVHADSGRRIPFGDLVEDAMALPMP
EDPTFRPDSERTLTGRKVARLDTPAKVTGKAVYGIDVEREGMLYGAVRLAPVFSADVETF
DESSVSGMPGVVAVVSVPRGMVVVADSWWQAKQAADTLDITFTRTPADTLSTDEINAMLR
EGLDRTDAPVTTLRGEAEATLSDDGQVVEAEYSVPLLTHASMEPINCTAESTEERTELWI
GTQGQDVVRMTLENAMQIPADRFFINTTYLGGGFGRKTHGEIALQAALASRAVDGRPVKV
LWAREDDVQQGQYRQTMMCRFRAVLNEAGQITGMRIRVSGPQMGREYGIDPEQRAQSTGN
LANFDPFSLGGLSDMRYVIPNFVVDHAVVDLPIPLCPWRSIAHSFNGFFFESFMDECAAA
ADRDPLEFRRSHCTDQARMLAVLDRVAEISHWQEPAAKGISRGFAVVESYGSYVAQVVEA
RADDEGIQVERVYAAIDCGRAINPGQVEAQIQGAVIDALGAAMRQKVTIRDGHAEQSNFH
DYPLLRIGEAPAVTVSIVDIGSPLGGVGEPGIPPLAPALANALFAATQQRIRHLPLSDHV
QG
>A0A369Q3G5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alteripontixanthobacter maritimus|TrEMBL
MGVTRRGVLVGAALGGGLLAAWGLAPRNFSTPLTPGRGEQAFGAWLTIGDDGVVTVAVPQ
LEMGQGVTTILPQIIATELGADWRQIAVEPAPVSGAYANIPMAAKWAPLWLPGSASMLRD
MTQDSWLASRYAQETRFTATAGGSTLEAYELPCREAAAAARMMLTEEAAARWNVDPLACT
VADGFVRHDRQQASFAELADDAAQRDLPDPLVLRAEPAGETVLPGIGEDTLTFPRLDLPS
KVDGSMLFAGDVRLPDMTYAAIRHAPAGTASLGRFRTAAVKDMAGLIKIVEGKDWLAAIA
ETSWLAERALAHLAPVFRAEDRADSLVIEAALDEGVRRGKSAVVARSGDAEASFYDPDFA
LRYDIAPALHATLETTTATARLKDGRLELWVAAQAPERAREAAAKAVGVRLSDTVLYPMP
AGGSFDRRLEHGHAIEAALLAREMEGRPVQLTWSRWQEHLAGYPRTPAAAVVTAKLTSDG
TLRTMKTRIAAPPAMLEFGHRLFGNLTPAAARRESVGKPDPLALEGALPPYNLPAAAVEH
APVDIGLPVAPMRGQGHGITAFITESFIDEVATRAGREPLSYRIAMLGGDPRMVECLQRA
ARIAQWGGGGDRSGQGLACHRMGDTESGGRIACIATARPDSGGEDGGASGGVRVTSLHAA
VDIGRIVNLDIARQQIEGGLIYGLGLAVGSATGYRQGLPTARSLADLDLPTLASSPDITV
EFVASDEAPFDPGELGAVIAAPAIANALFSATGLRLRRLPLLSEGL
>A0A369Q2Q6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alteripontixanthobacter maritimus|TrEMBL
MPRMTVNERPVEFTLDPETPLLFALREAANLTGTKNGCGAGGAGGSDDSGLGAGDCGACM
VIVDGEALRSCLITIAEAEGRFITTIEGLSRDRSHPVQQALVAEQAIQCGFCTPGIAMAA
AALLAKNEAPSKADIEAAIPNLCRCGVYPRLVEAVQRAGRVAARRETISAAPAPGISAED
AAREVPALGRRE
>A0A0H5CYK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter italicus|TrEMBL
MAISININGEQREVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLNGEPVRSCQ
TYIEDVEDAEITTIEKMAEDRVGAAVQQAWLELDVVQCGYCQSGQIMSAVGLLRENAKPT
AEDVDEYMYGNACRCATYQRIRAGVLRAAEILEA
>A0A7Y7LR36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. SG517|TrEMBL
MIDININGKSVALDAPDDMPLLWALRDIVGLTGTKFGCGIAQCGACTVHLDGQPVRSCVL
PVGSIGKKAVTTIEAIAQTPAGKSIQKAWLDVDVVQCGYCQSGQIMSAAALIQRTPNPSD
ADIDLAMSGNVCRCCTYSRIRAAIKQAATGKAEVLQSVAVMPARSAS
>A0A0C4Y066|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MRIRYLEALAGGNRGHAHAGGAAALDRRSFLKLTGFAGGGLALGILPAQAALAQEGAAPK
APPSPPQAFLLIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAGDA
YKDPAFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAATQWQVDPSSCQVALGVVTAG
SHRATFGELAQAAMALPVPQQVTLKNPAQFKLIGKPTRRLDARGKLEATTAFGIDVHLKN
MVVAVVARPPRFGGKVKSFNADKARAIKGVADVMLVPVDRGGTGVAVVANGYWPAKQARD
ALEIVWEDSGSSVSTKDLFAQYRTLAAQPGTVALQADMGAMSGAARTISADYEFPYLAHA
PMEPLNCTLQAEVSGKAVQSVKVWVGSQFQTVDQAAIGRVLGLAPAKVTLNTMMAGGGFG
RRAVPTSDYLVEAANVLLAWVKNGHDEPLKVMWSREDDIRGGYYRPLHVHRARIGTDAKG
QVLGWQHTVVGQSILSGTPFEAFMVKGGVDSTMVEGLVENDYGFPLQLSVHHPQVAVPVL
WWRSVGNTHTAFVKETLVDEVAVNARQDPVAYRLARLDAGKHARHRAALQLAVDKSGYGK
RKLPKGQAWGVAVHESFGTVVAYVVEVSLVKNEPHVHRVTAGVHANRVVNPMSAEAQVQG
ACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSEDPPTGLGEPGV
PAIAPAVANALFTLTGKRQRQLPFVLA
>A0A7W5ZHX5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella defluvii|TrEMBL
MENADKKPKKGFSRRKFLAISGSGVAGTLALLYFGRGAIRRKISDFTSEMDIPADVSDFD
HKLWFEVNADNTITLKSPKAEMGQGIFTGFAMLAAEELDVAVEKIKVVHANSLNGLLSNT
GGSNSTSSFYVSIREVAATLRETLKLQASKLWNIPVASISTKDGMLTAGDKQLSYADLAK
QITKWETTETPALRPSSQFKYVGKQQKRIDLPDKVLGKPIYGIDVTLPDMVYGAMLYSPY
VKGTLKSADTSGAKNTAGVLKIVEETNWIGVVATSRYAAQTAVEKIKAEWDYNPNVSTKD
LEKLITVGNGKEVNIQNDGDTDSVPDEVLTGEFRTPIGFHGNLEPSIVVADYKDNKITLY
ASFQNPAYLQTSVAEALDLKTEDVAIMPTYMGGGFGRKAFKSNAVEAAKLSKAVGKPVHL
LATRQQEFQNGYVRPNTHHVLKGKVGKDGKILAFVHHLATGPMIFNSVPAIAETILGADF
IVAGHGARCPYHVTNIKTTVWHNNLPFETSIWRGVGMFANTFAIESFMDELAHKAGVNPL
KLRIDHCNDTPQLVRRKKLLEIIGEKSGWHLPKSEGIGRGLAVCDDRKTVSAAVVEVKIV
DGAIKIVKVTQAIDAGKIINPDGIKQQVEGATMMAISATLYEQGTVENGQFVQTNFHNYQ
VVRLSDTPEIEVILHEGSEVPSGVGEPPLSPIAPAIANAIFDLTGKRLRSLPLQLAFQAA
SNL
>A0A0R2YGW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MNTPIKIPQGLLDLASGEPINLSRRRFLASTAVGALVIGFGLPLGSARVQAATSAAERGT
QVPAFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVESAPPGEAYVVM
ENGMRITGGSMSVRMSYPTMRRLGALARAMLLQAAAEQMGVPVAQLTTQPGRVVHTASGR
SLGYGELAGRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYCIDLKVDG
MLHAAVQHAPRLGMSVGSLRNQAEVQAMQGVHSVHVLPGAVAVVAERWWHAKRAVEAIQV
DWQQAPADSTVRVMPADFSSDKHRDFLAAQQGPARDDENEGDVAGALAAAKTQVQATYHN
QYLNHAQLEPPSALARYNPDGTLEVWLPNQAPDMFRNDIAKRTGLAAEKITLHSPLLGGF
FGRHFLYESANPYPQAIELAKAVGRPIKLIWTREEEFLRDVLRPVAVVKFRAGLDANGLP
VAIEAVSATEGPTEALAGKQGEKIDPTAMEGLSGKAYAIANKRIAQIYVKGPVMLGYWRS
VGNSLNDFFYEAFLDELADKGGQDPFDLRLHLLRDNPRLTTLLQAVGELSGGWKRGPFTA
EDGSRRARGVAMASPFGSHAAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIIEAQVHGA
VALGLSQTLIEEAVYVDGKPRARNYDLYPVLPPARMARVHVRIVESGEKMGGIGEPPLPA
VAPAVANAVAQLTGQRIRSLPLSRYTFS
>U2ENG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinisphaera shabanensis E1L3A|TrEMBL
MSERMTDAPPDLSILDRNADDRTYMAEGIACLQNGLELGDPLDIERYRVLLRRLYAAGRF
DLALGRLFEGHIDALQIIHRYGEADAAKRLHDAARHGARFGVWNAPLAGEALRLDDGRLD
GGKAFASGAGLITHALVTADVADGPGKQLLVVDLAHTPPDIDTRWWQVLGMQRSHTHLVR
WRNAALTANDMRIGKLGDYEREPWLSAGALRFVAVHAGGIAGLFDGVRRHLVMRERESDP
HQAARLGRLFGLADSAAAIVERTATRLYETDAQTHPALVANARSVVLDVGEQALTLAQQC
VGLSAFFETDALCGHMADLMVYLRQPAPDAQRVKTGAAAAARHIELSL
>U2E6F9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinisphaera shabanensis E1L3A|TrEMBL
MDFSYSDEQRMLKDMVDRVVADQYSFEQREKIIKSDTGYSPEVWSQFAELGLLAVPFSEA
AGGFNGGGAELMVVAEGFGRGLVVEPYLSTVVLAGTFLDAALGDDAKADALEPIISGEQK
YALACYEPNGRYDPFWIETTAKKDGDSYVLSGKKAVVLGGDSADRLLVIARSSGDNPGKN
GLSAFLVDGNADGVSRDGYTTFDGHRAAEIVLDNVKVGADALVGEEGGAAAPLQYALDRG
IIALCAEAAGAMEVACDLTLDYIKERKQFGVPIGSFQALQHRMVDMRISLEKVRSLALWA
ACSLDAPDAERRQRLAAAKAMVSKAGRHVAEEAIQLFGGMGMMDESSISHYAKRIVLIDH
YLGDGNYHTDRLIDLLVEENAAA
>A0A0A0HPU4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus DSM 17069|TrEMBL
MQLTVNGTDHSLEGLEPDMPLLWALRDILGLTGVKYGCGIAQCGACTVHIDGVATRSCQV
AVGDVWGPVTTIEGLGTPEALHPVQAAWITHQVAQCGYCQSGQIMQAASLLSESPNPTDT
EIDDAMSGNLCRCGTYPRIREAVKTAARNLRGI
>A0A839UI98|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Simiduia aestuariiviva|TrEMBL
MLQLTINGESRTVDADPNMPLLWVLRDLLQLTGTKYGCGKGLCGACTVHLNGTAVRACSL
PVAAAVGGKITTIEGLSVNGDHPLQRAWTEHKVPQCGYCQSGQLMSAAALLARNPTPSAA
QIRDAMSGNICRCGTYPRIEAAIKTAAGVQIQPAQGGK
>A0A0P1F5F5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shimia marina|TrEMBL
MAISLKLNGKTHEVEAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHMNGEPVRSCQ
TYIEDVEDAEITTIEKMEEDKVGAAVQQAWLELDVVQCGYCQSGQIMNAVGLLRENAKPT
AEEIDDYMYGNACRCATYQRIRAGVQRAAKILEA
>A0A7Y9RTI7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides perillae|TrEMBL
MPRQTFVLNGKTVTVDVADDVRLLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
AVPVGALKPGDKITTIEGLPEQVRDSERGPNGLHPMQEAWLDRDVAQCGYCQPGQIMAAV
ALVKKVRREGRSLTEADLDGIRNICRCGTYTRIREAIKQGARDM
>A0A220W7C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus sp. SMR4y|TrEMBL
MTKFTVNDRPVQYRMDPDTPLLWALRDASNLTGTKYGCGTGDCGACMVEVDGEAIRSCLV
TIGEMEGRFVTTIEALSRDRSHPVQQAWAAENVPQCGFCQSGMIMAAAVLLKKNPNPSRA
AIDEAITNICRCGTYPRIREAIQRAGRVARGEAVLSAAPPPGIDPDDAARAVPALTPEK
>A0A5Q4YX54|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia dioscoreae|TrEMBL
MLKRRTFLLGGAGAVGALLVGWSVLPPGQRLTTSMPLPAQGTQVALNGWVKISADNSVTI
MMCKAEMGQGIHTGLAMLLAEELDADWSQVRVEDSPIDRIYNSVQNIIDDLPFRPDDDSA
IKRATVWMTRKVVREAGTMMTGGSSSINDLWTPMREAGASARAMLIGAAAAQWKVPAGEC
RAEGGQVLHPSGHKASFGELSSMAAQQPLPRQVALKDPADFKLIGKPVRRIEAASKINGT
VRFGIDALPDGLLYASVVMCPTLGGSVARFDATAAGKMPGFIKAFAVAPYNGGTGGVAVI
ADNPFRAMNAVTAVAVDWHDGPAAKLSNADVDRRLAQALDDGDGHAYYHLGDVDAALSRA
ARTVSAEYRAPYLAHGAVEPPNCTVQVTDGSATVWVSTQMPALARHHVAKVLDLDTDKVD
VQTLLLGGAFGRRLELDFIAQAAAIAREGGGRPVQTIWSRAQDFTHDFYRPACVSRLKAG
FDNDGKLVAWQATSASQAIVPESLARYYGVPRIPIDKTTCEGAFDQPYEWPAARVAHKIV
ELPVPVGFWRSVGHSHQAFFTEGFTDELAVAAGQDPIAFRAALLAQHPRHLAVLRRVAAL
SDWGHSLTHAADGALRARGVALHEAFGSVVAQVAEVSIGPDKGIRVHRVVCVIDCGMPVN
PNLIRQQMESAIVFGLSTALQDEITLVNGQVQQKNFVDFPVVRINDCPVIDTDIMPSQMH
PQGVGEPGVPPVAPAVANAVFALTGQRLRSLPLKLA
>A0A5Q4ZTN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia dioscoreae|TrEMBL
MSQGLLDAQNGAEPSKAGARAAGGLSRRTFLKFGVTVGAAAGGGLLLGFSMPAASQDQKA
GKSVIGGDGVETPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LDTVTVDHAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRKAGATARTVLISAAAQQWQV
DPASCHAQAGQVIHAASKRSIGYGQLVTAAASLPAPQNVKLKDPKDFKLIGTAVKRLDSP
EKVDGTALFGLDVRVPDMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQVIKIDNAVAVI
GDHTWAAKRGVQALVIKWNEGSGANLSMKQIVDDLANASQRNGAVARKDGDVANAFSNAK
TRVDAVYQQPFLAHATMEPINCTVHVRPDGCDVWLGSQVPTRVVDAAVAVTGLPADKIVV
HNHLIGGGFGRRLEFDMVTQAVKVGKQVSTPVKVVWTREEDIQHDMYRPYYYDKISAGLD
SNSKPIAWQHRIVGSSVIARFAPPAFKNGVDPDAVEVASDLPYDLPNQLVDYVRQEPHAV
PTAFWRGVGPTRSTFVVESFIDELAAQAKVDPVKYRQDLLGKTPRALNVLNVATQAANWG
SAVPKGQGRGVSVMHAFGSFFGIVVDVAVDQGEVAVKRVVCAVDCGMVVNPNTVEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIEVHIVKSSEAPGGIGEPGTA
ALAPALTNAIFAATGKRLRQLPVGSQLQTA
>A0A8B6M113|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylocella tundrae|TrEMBL
MAYTIKVNGVERTADVDGDTPLLWVLRDVFGMTGTKFGCGASLCGACTVHQDGNAIRSCI
TSIDSIGGSSITTIEAIGDTPSGAKIQKAWLDLEAPQCGYCQSGQIMSAAALLAGNAHPS
DNDIDEAMSGNICRCGTYSRIREAIKLAAGENAVKQGG
>A0A0Q0MQT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas sp. P1-25|TrEMBL
MVTFTVNGKEVKSQASADTPLLWVIRDEIGLKGTKFGCGIAMCGACTVHLDGQATRSCVL
PVGAVAGKNITTIEGLNNEHPLQKAWVDEQVPQCGYCQSGQIMQAATLLADNPNPTEQEI
VNHMNGNYCRCMAYKRIKSAIQRAADESQSAVQMFNPKELDV
>A0A841N118|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MATLTKTNRRDFLKIAGTTAGGLFIGFNWLGCDSPKMEVLSDEQVLSQAKNFNAYLSIAP
SGDIVIYSPNPELGQNIKTSFPMVVAEELDADWKKVRVLQANLDTEKFDRQLTGGSGAMP
HSWERLRKAGATARYLLVAAAANEWAVPAEEITTSEGMIFHKGSGKEASYGDMAIAASMI
EAPEDVVLKDKKDFKIIGTPVKNVDSRAIYTGKPLYGLDFYREGMMHAMVQRPPFGMKIK
SVDDTAAKAVNGVSQVVTFDNSVAVIGNSTWPLMKAKKLLKVEYEPDGMVESTSDHDRIF
REMLDSGKAEERRRDGNVDMAFKNAAQVVTAEYQCPFLSHSPMEPMNFFAHVKENSAELI
GPTQTPDRAASSAAEILGIPKENITVEITRLGGGFGRRLRADYADEAVKISKLINAPVKV
TWSREDDLTGGAYRPAVRYRFEAALDSDGNMIGYKLKGAGINAGNSTRQNNFPSGAVDNV
LIESIDHQSPITTNAWRAPITNFLAYAEQSFLDEVAMAAKKDPVEFRLALLEKAKANPVG
GELGYDADRMIGVIKTAAEKSNWGKNPNVSQGFSVYFSHRTYVAQVADIEMENGAPVLKK
ITAATDCGMVINPTGANHQVRGGIVDGMGHAMYGNLTFENGLPTQKNFDKYRLIRMKEVP
QIDVHYVDSGFDPTGLGEPALPPTGGAVANAIYKATERRLRTQPFIEQKEFEDLNLVIKR
S
>A0A7W6F9W1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium brachythecii|TrEMBL
MNKPLSDRDFAPLHRRGFLTGVGALVVAASLPAGPRVARAAGAEFAPNAFIRIAGDGKIT
LIMRDVEMGQGIWTGASMLLAEELDVGLDQVTPEFAPPDEKLYASPVLMTQATGGSTSIR
GDWEQFRKTAAITRSVLVQAASQQWGVDAATCTVERGTVHHAASGRSATYGSLAALAATL
PLPADAPLKPKETWKLIGTPQKRLDTATKVNGGTVYGIDVQVPGQKVASVAMCPVLGGKL
RKVEDVAARKIKGVVAVLKLDNGVAVVGDHFGAAQKGLDALEIEWDLGPNARLSQAEIVE
GHRVASRGNGIVAKAEGDAPAAISGAAVKLDAVYQLPFLSHAPMEPINCTVHVKPDGVEV
WCGTQVPGRAQDEAAKAAGVEKAKVTIHSHMIGGGFGRRLEAEYVGIATALAKQVPYPLK
MIWSRETDIRHDRFRPYYYDQVSAGLDAKGRIVGWTHKVTGSTVMARWAPPGMKPNGLDP
DTVECAEETPYEIPAHHVSWVRHEPPGVVTAWWRGVGPAHNVFVVEGFIDELAHAAKQDP
VAFRKPLLAKNPRSLKVLELAAEKAGWGAPLPKGVGRGIMLENAFGSFLSVVCEAEVAEG
GDVRLRRIVAALDCGQVINPDSVKAQIEGGLVFGLTAALYGEITLDKGRVQQSNFNTYRM
LRMNETPPIEVHLVDSSEKPGGLGETGTAAAFPAVANAVFAASGRRVRTLPILSNAKVG
>A0A7W6WZF3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MNAHNSVSRRALLTSGLATGFLLAFHLPLRAAANEPVQPSDTTEGKFAPNAFIRIDETGR
TVLMMPQVEMGQGTYTSISAVLAEELDADWSKVEVQHAPPNDKLYGNPTFGLQVTGNSNS
IRAWWLPLRQAGATARAMLVQAAASQWGVEPASCTASKGEVAHDASGRKLGYGALALAAQ
GQTPPKDVALKDPKDFVIIGQPLKRLDTPDKVNGKAVYGIDAILPGMKFATVAACPVFGG
KVGKVDDSAAMKLPGVRKVVVLDDMVAVIGDHMWAAKKGLEALKIEWNEGPNAEITTKDI
WEDLRKASQKDGAVAKSDGDIAKALVSGDRFEAAYELPFLAHASMEPINATVHVKADSCE
IWTGTQIMTRVQSEAAKAAGLPIDKVIVNNHLLGGGFGRKLEPDMVIAAVKIAKQVDYPV
KVVWTREEDIQHDVYRPVYRDQITASLVDGKVAGWKYKVAGSAVLARWLPPAFQKGIDID
AIDAAVDAPYDFANFHVEYVRAEPPAVPTGFWRGVGPNNNVFAVECAMDELARKAGKDPI
EFRKSMLTKNPRMLAVLGQVAEKSGWGQKLPPRVGRGVCVQPSFASFIATVVEAEIDDIG
EITLRRITSVVDTGIAVNPDTVKAQIEGGLIFGLTAALYGEITIDRGRVQQSNFHDYRMM
RINETPKIEVIVVRSGEAPGGIGEAGVNAGPPALRNAIYAATGVALRRLPIDRKLLAAGK
KA
>A0A7W7VCI7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinophytocola algeriensis|TrEMBL
MITRRAFLGTAGVLVVSVSVPGTSGATSAAGALAPTVFVRVDRRGRVVATVPKPDAGQGV
RTMAAVLVAEELAVEVADVALEQAPGDTATYGSQAVANSSSSRQLAEPLRTAAATARCLL
VAAAAARWGVPPEECVARAGRVEHPRRKALPYRVLVSEAAALDPATVPVTLTPPERWRLI
GRTRAGRADARDIVTGRARYGIDAPPSGSLVAVVARPPWLGALVSSAADAAALAVPGVVA
VVRLDPPAAGQGGVAVIASSTAAALRGRDALRVGWTGGTPAADSREWLAGLESALPAAPA
ADVRRVYRLPLLAHAPMEPMNATAHVTATGAEVWAPTQDPGRVRTQVARQLGLPESAVRV
TATLAGGAFGRRIETDPVLEAVACARAAGRPVTVRWTRDDDTRHDSYRPMSVHRLSATLD
ADGLPVGRSHQVATWPLTVNPAFDNPAIVRLSGNHFPYAVPGDVSVTLRPAPLRTGFWRA
VYAGQFGYAEECFLGEVARRGGHDQVDVRRRLLPEDSRLRRVLDVAAERAGRAGSSSRGV
ACHLDYGSAIAVIADADPGTRRVVRVHAAVDVGVAVHPSGVVAQVEGGVLDALSTVLGAQ
ITVRDGAVVQSSFRDYPWARIGDCPDIDVRLVPSTAPIGGLGELAYPPAAAAIASALAEG
GDPVTGMPYGAPVG
>A0A7W7Q8A4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinophytocola algeriensis|TrEMBL
MPEHTFRVNGEQVTVDVADDVRLLWVLRDILGITGPKYGCGINVCKACTSHLNSTAVNPC
AIPVSDLEPTDEVTTIEGLPATVGQELHPMQQAWLDHDVAQCGYCQPGQIMAAVALVRRI
AAEGRAITDADLDGLRNICRCGTYFRIREAIKAGARNM
>A0A1B7JNS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Providencia heimbachae ATCC 35613|TrEMBL
MSVFDITRRRLLQAGGVIMVSHMVPNLSFASANLLDKNAVIPLDYVDSFIALAADGHVTA
FNGHVDLGTGIRTSLAQIVADEIGVPFYSVTMILGDTQYTPDQGPTIASATIQVTSIPLR
QAAAQVRLQLMTLAAKAFAVSVGDLRTENGEVLVAARPERRLSYAQLAKGQNLHFELDEK
VTLKPASEAFYVGKSVPRVDIKGKVTGELTWVHDMRVPNMLHGRVIRPPYAGADSSAPLG
NSLISIDETSIAHLSGIVKIVRINDFVGVVAEREEQAIEAMRQLKVTWKKWDGLPDLSLD
QLHETLDVQPSEKRMLRDDKGFDNALDSLTKTVNSDYVWPYHLHASIGPSCAVADVKGDK
VDVWSGTQNPHDLRKDLALQLGRDLSQIYVHRMEASGCYGRNCADDVSADAVLLSEATGW
PVRVQLMREQEAGWEPKGTGQLIQVRGGVNEKNEVAAYEFTTRYPSNNATTLSLILTGKK
ENKADVQQMGDRTAIPQYLYPLMRVMSKDTAPIVRASWMRGVSALPNVFAHESWIDEIAY
LAKQDPIAYRLRYLDDPRAIALIHAVKKQANWVDGPMHRNPAPASQEIVSGRGFAWARYF
HSKFPGFGAAWAAWVCDLTVNRRTGQVVIKKVYVAHDCGQMINPDGVRHQVHGNIIQSCS
RVLKEFATFDKSGTTSLEWGGYPILRFDELPEIDIQLVDMPNEPPMGAGESAAVPSAAAV
ANALFDALGVRMREVPFTPERILRAVDTASNAQGASHE
>A0A508T656|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MIKLKINGQEQNWDGDPDLSLLWYLRDEAGLTGTKYGCGQALCGACTVIVDKEAVRACIT
SVSDVVGREVVTIEGLHPTGDHPVQKAWRQVNVPQCGYCQAGQIMQAAALLNENPKPSHD
QIREAMSGNICRCGCYQRIENAVHLASTGV
>A0A7U3ZLU1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MEKVKTTYNRRSFLKASALSGGGMMLSIGWLSSFKSAETQGLTNLPLDFNELNGFVKITA
DNVIKIMSPNPEGGQGVKTSMPMIVAEELDVDFSKIVIEQADLDTKHFTRQFIGGSQAIH
QGWKPLRTAGATARQMLMEAAGKTWSVPVEEVSTEAGVLYHKKSGKTAKYGEMATAAAQI
PVPKEVKLKNVNEFKIIGKSQRNVDLEKIVSGKPLFGIDTQKEGMLIAMIVHPPAFGMKF
KSTDDAAVRKMKGIKDVFPVKIFHDDYERQYFDTTTFLEVVAIVGNSTWEVMQAKKALEI
EWEPFADYSEKKNMLGRKLTAKVPAGLESTADHYSKMATMADKPATVRRKDGDPETAFKN
AAKVLERTYTGPFLAHNCMEPMNFFAHVTEEKAELAGPIQKPENTELALSARLGMPVEKI
DIKMTRLGGGFGRRSYAHWLIEAALISQKMKAPVKLLYTREDDMTSGIYRSAYSATYRAA
LDANNNLIGFHVKAGGVPESPLFANRFPAGAVENYLAEDWSIETNLTVGSFRAPRSNFMA
AAEQSFLDEVAETAGKDPIAFRLELLKRAKESPVGKNNEYEPERYAGVLELVREKSGYEQ
TKNSKNLGVSAYFCHDSYAAHVFDLEMKEGIPVVNKVFCAVDCGIVINPNAAKNMTEGAI
VDGIGTALFGNMTFTKGVPDKSNFNRYRMIRMNEAPKQINVHFVQNTIDPSGMGEPAYPP
VFGALANALYKATGRRFYNQPFNSALPEQ
>A0A7W5IHH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WP4_3_2|TrEMBL
MRDPKLTHDGARAAISRRQFLAGMSALTLAVGFRGGLAVAATLDPAKNATQFSFEPNAFI
RVDASGAVTVIAEYLEMGQGTFTGLATLAADELDVPLDKVSVEAAPADVKKYANPMFAAF
GWTLQATGGSTAMAGAWKQMREAAAAARVMLVSAAAKQWKVDPATLHVEDGVIVHAASGR
RAGYGQFVAAAAREPVPAKVALKQPGEFRLIGKRDTKRVDIPAKVNGSAIYTQDMKLPGM
LVAVIAHPPRLGGTVRHVDASKAKAIRGVVAVVQIPGDDEVQGGVAVLASNTWIARQGRD
ALNITWDDSRAFALSSTDIFSQFRTLADQPGNVAEQRGKVLTAAPEGGKYIEAVYEQPYL
AHAPMEPMNCLIQLQGDRCEIWNGEQWHTADQSMAAKELGLKPEQVTIHQLYAGGSFGRR
ANPHSDFVREAARVARAAHAQGVTAPVKLVWMREDDMRAGYYRPLTVHKVRVAVDKAGAL
VSWNHDVVGQSFMQLPKPDSIDPVLVEGAADIPYAIPNFRVAQHKAKLPVQTQWMRSVGH
THSAFVGETMMDEAARAAGKDPYAFRHALLGNMPRHRGVLELVAQKAAWSTPLKPGPQGT
RRGRGIALQLAFGTYVAQVAEVTVQADGAFTVDRVVCAVDCGMVVNPDIVATQVEGGIGF
GLTFLRTAITFDKGHVRQGNFNDYPVLRMSGMPVVEVHIVPSKEAPTGIGEPGVPPAAPA
VANALAAATGATIRSLPLGDALRPA
>A0A5E7HQ92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIRTIENESRRRFLKGTAGLTLAVYLPWSLADGTARGGKGGEFEPNAFLRIGEDNVVTVI
SKHLEMGQGAYTGLATLVAEELDADWAQVRVESAPAESRYNNSLLGIQGTGGSSSIANSW
EELRKAGATARAMLVSAAAWLWKVPAQEIEVVDGVLRHAASGKQATFGQLAKLASEQPVP
PEVKLKDPSTFKLIGRQKLARKDSADKVNGKAIYTQDIHLPGMLTAVVAHPPRFGATVKS
FDAKSALAIPGVVHVVQIPSGVAVVAHDTWSAKKGRDAVSIQWDESGAFKQSSEQLFQRY
RELAKTQGAVVRDDGDVTAGLAGARRTLEAEYDVPFLAHSAMEPMNCVVALTKDGCETWH
GAQMQTHVQKVLAELFGLKPEQVRINTLFAGGSFGRRASKDADYVLENAHIVKAIGGRAP
VKLVWLREDDMQAGHYRPMYHHRLSAGLDDQGKLVAWQHRMVGQSVFAGSPFAAFIKDGI
DSTSVEGGSTLPYRIPNLRVDLHTPTDIPVPIQWWRVVGHSHNAFSTECFFDELAYMAGQ
DPVAWRLAMLEGHSRHIEALKLVAQKAGWDKPLAAGKPGERRGRGVALHEAFGSVVAQVA
EVTVQKDGKFKVDRVVCSVECGIAVNPDVIRAQVEGSVGFALSATLHEAITLTDGKIDQS
NFHNNEPLRIYDMPKVEVHIVPSANPPTGIGEPPVAPLAPALVNALAAATGKRIRRLPIS
DQLSA
>A0A5E6TH55|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDALAEDKPKQFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHKPSGRELGYG
ELAAAASALAVPARDSLRLKQPSEFRYIGKEGTKAIDGDDIVNGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSVDDSAALKVPGVLKVIQIESRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQAPMEPMVAIARYKDGVCEAWAPSQAPQVTRERIGERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGEDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E7NG09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSPIDDSRIELPRRVFLKQAATIASGLAIALYLPSAIAATDPKAPAPASEFEPNAWVRIF
PDGTVKLVVHKHDSGTGTHTALAACVAEELDVNPLTVQVITPEDPFFETYIHPVWKVFST
GGSTSVSLEYDRLRMAGATARALLITAAAKQWKVSPDSCTTEEGRVMHTASKRSLGYGEL
VGVAANLPAPTNVTLKDPAQFKYIGKLRHKRDAAAKVCGRFKYSIDVQLPGMLVAVILRA
PVVGAKVVSVDSAAALQVPGVRKVLAIPGRPDVLGGNLEGVAVLADTFWAAQQGRKALEI
QWSDSPLAGFDSEQLFSAQAKAIGDPTAQTVKAMTQGDVAGQWAGAAQLIEADYTMPYKV
QNPLEPICITAQVKDKAITYWGGVQVPFSALEAAQTVCGTDKANVTIHELVSGGSFGARE
AKYWLFEVAYLAQKTGVPVKLLNSREDEMHALFYHPATLHRVKGALDAQGKLSALQLHAV
SPASPEQWEPGYFERPDKMDYSTTEAITAWDFAYRPPHLQLNWVKHESNVPSGWYRSVSF
IPNVFAVESFMDELAHAAGADPLAFRLANMQERPRHVAVLKQAAERAGWGKPLPPGTALG
IATNQGYTSFIAVVARVATVDGKPKVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGFGHAL
FDRLDIKQGRVVQSNFHDYRVTRMSDMPATDILVLDGEPSKPGGVGELGSPSVVPAIANA
LFALTGVRQRSTPLSLG
>A0A5E7KH82|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PATAVAHGQKILTIEGLSTDGMHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEMGSS
>A0A379JBN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPSNFALSNLSRRGFLKGVGATGALVVAASWGLPKAFADEVKQYGGAAMPNGLVDDP
KVYVSIATDGTVTVICNRSEMGQGVRTSLTMVVADELEADWALVKVAQAPGDEARFGNQD
TDGSRSMRHWFEPMRRCGAAVRTMLEQAAAEQWKVPLGECRAQLHKVIHQPSGRELGYGA
LAAAASALAVPARDSLRLKQPSEFRYIGKEATKAIDGADIVNGRAVYGADVHFDGMLFAT
IARPKVYGGKVKSFDASAALKVPGVIKVLQIESRPIPSEFQPLGGVAVVASNTWAAIKGR
EALQIVWDDGANAGYNSTDYRKTLEAAALQPGKVVRNTGSIEQALNDADSTLEATYYLPH
LAQSPMEPMVAVARYQDGRCEAWAPSQAPQVTRERVAERLGLPFDNVTIHVTLLGGGFGR
KSKPDFIIEAALLAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGLNKDGLPSGWLH
RTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAAHTRVGWYRSVSNIP
HGFAIQSFVDELAHKAGQDPLKYQLKLLGPDRQIDPRTLSEEWNYGESPERYPIDTARMR
GVLETAAKAAGWGRTLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIALDCG
PQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPREIAIHLV
TPEGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRSLPVRYQLQGWQQAAKA
>A0A5E7R1N7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MAMNSLNPLSRRGFLKAGAVLGGGLVVAFVIPGAHRFAVGAENQGNVFAPNAFLRIGNDN
SVTVLLGHSEMGQGIWTGLTMLIAEELDADWSTIRVEHSPASAKDYGLAGFGGMQITGGS
TSTWMEFDRYRQAGAAARLMLIEAAAKRFNVAPSTIRTESGVVMAGDQRATYGELADDAG
KLPVPDPASIKLKDAKDWTIIGRPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPVF
GGSVKSFEGAGALAIPGVHKVVQVPTGVAVIADHYWAAKLGRDALHVEWDPGPNAGLDSH
KLLESFRKLAATPGLPASQAGDTKAALGKAAKTLDVEYSVPYLAHAPMEPLNCTVKITQD
KCEIWTGTQFQTLDQMIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKA
AGGPVKTVWAREDDIRGGYYRSAFLHQARVGLGADGLPMAWKHVLVGQSIMADTSLEASM
VKNGIDKTSVEGVADSPYLEGLANHQVELHSPKTGISVLWLRSVGHTHTAFVMESLIDEL
ATAAGKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQV
AEVSQDNLAIRVHRVVCAVDCGIAVNPKSIEAQMESCIAFGLGFTLHSKLTIKDGQVVQS
NYHDYQVLRLNEMPVVEVHILPSSEKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQ
LSGV
>A0A5E7IK50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDIAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A4YKH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MNALLKTDLANALPLLRPQGITNLSRRRLLGLGAGALVLGALLPAAGARAATAAAVKPGT
RVPAFLVIGKDNSVKLLSPFVEGGQGINTGLAQIVGEELDVHLNRFEVECAPPGADYAII
NGLRLTGGSFSTRSSYEVMRRLGASAREMLIRVAAAKLDVTPETLTTEDGQVVHAASNRR
VPYGELAEQALALTPADTVALRDPATFRYIRQPMPRLDVRAKSTGKAVYAIDQKIEGMLY
AAIQHAPVLGTEPERMVNEATVKAMPGVHAVHKLPGAVAVTADSWYRARKAVETLDVAWS
KAPASGFDAVAADYSSANLLAALKASDANGVSAEKAGDVAAAFASAATIVEAEYDAPYLA
HGQLEPPSSMARFNADGTLELWVPNQMPELFQGIAAKVGGVTPDRVILHSPMLGGFFGRH
FAYGSSNPFQQAILLAKATQRPVKVLWSREEEFKMDALRPLSFSRFKAALDKDGKPAAIQ
VRTVGEGPMGRWFGVTAGGKVDSSAVEGIVEKPYAIANRSMEYARFAHPVTIAFWRSVGH
SMNDYFYEGFLDELADAGKQDPYQLRLALLQDRPRHFKLLETVAKMSGGWRRGPYDADGG
KRARGVALASPFGSETATIAEVSLEKSEVRVHQLWIAFDPGSIVNPAIVKSQVESAAALG
LSAALFEELVYKDGQRQSHNFDDYPILSRASMPKVDVEIVESGAPMGGVGEPGLPGIAPA
VVNAVAALTGRHVRSLPLAKAKLGV
>A0A2K8PNR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces lavendulae subsp. lavendulae|TrEMBL
MPSHTFTVNGRSVTVDAPDDLPLLWVLRDMLGVTGPKYGCGVDVCKACTSHLDGTDVRPC
VVPVSACAGKRVTTIEGLADGDVLHPVQEAWLEQDVAQCGFCQPGQIMAAVALLRRTSEP
TDEDIDAIANICRCGTYFRIREAIRSAAARM
>M9RDG4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Octadecabacter antarcticus 307|TrEMBL
MTTQLMINGTSYDVALPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVQIDGEAVRSCQ
VALADVWGDVTTIEGLGNPGNMATIQQAWVDHQVAQCGYCQSGQIMNASVLLDDIPQPSD
QDIDDAMQGNLCRCGTYPRIRAAIKDAAQRIMDEV
>A0A7W6LSI7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium scionense|TrEMBL
MPYSLSVNGQVHSIDEDGQTPLLWVLRDTLKLTGTKYGCGVAQCGACTVHVDGQPMRSCS
LALEAVASAQIVTIEAVEGAETKAIQDAWIARDVPQCGFCQSGQVMSAVALLRAIPAPTD
DDVDIAMSGNICRCATYNRIRAAIHDAAGVLGSGRS
>A0A0P1E8K6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MATALKINGKQHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVITIEGIGTPDSMPAIQQAWVDHQVAQCGYCQSGQIMQAAALLAENPAPSD
TDIDDAMQGNLCRCGTYPRIRAAIHDAASKLKEA
>A0A6J4SNY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Sphingomonadaceae bacterium|TrEMBL
MTGRPVKLVLPRGQIFHIAAFRPLSRHKIKIGADAAGKMIAVEYDADQQQSPMGRFPPEY
HEGPMQMYGIADFEATTGNIRIDTQAPGWMRTPHPHPGCFAFDSAVDELAYKLGRDPVAF
RLAHDATVDPTNGRPLSSRHLNECIVEGARRFGWSRRNPRPAATVLRDGTQVGWGVGCGS
YPSMASPNMSTLRVSANGTTRFALSGQEMGQGIRNVIAGVLLGELDVDPNKLEIVIGDTA
AAPQHQTAGSWGTASVVSVTEGAARKLKASVEELLAGRRVLGNLHRQLATVRRPYVQIEE
NWLAPGQDAKAFQSMRDTGYARAGPDYPAFTSFSYIAHFVEVA
>A0A395KZ06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ensifer sp. M14|TrEMBL
MTVHDITTTRRTFLAGAGLVIGVAIAPKFLSAAPTGVPAGGAADLKPMNAFVKIGTDDTV
TVLSKHIEFGQGPFTGLATLVAEELDADWSQMRAVHSPTDNKIYANLAFGLQGTGGSSSI
ANAYEQMRKAGATARAMLVAAAAQEWSVPAAEITVEKGRIKHTGSGKESGFGAFADKAAR
QTAPAEPKLKDPKDFVLIGTDLPKLDTREKINGAAIFTLDIMPDGLLTAVVAHPKHFGAV
VKSFDDTDARKVMGVVDIRQIPQGIAVYGENTFAALKARDALRIEWDLSKAETRSSAELA
AEYIRHFEKPGLEATNNGDVAQAFQQPGLQTVEAQIIFPFLAHAPMEPLDAVFIKAADGS
VDIYNGAQFPGFDQQVAAKILSLDETKVRVNTQLAGGSFGRKAQFGSPYMQEAASVYAAI
GGDRPLKHMWTREDDIQGGFYRPMYAHKMRGAIDAKGQITAWEQIIVGQSIMAKADLDST
SVEGASNLPYRIPNLKVTSHNVTLPIPPLWWRSVGHTHTGFAVETFVDELLARVGRDPVE
GRLALLDATSRHAGVLRKAAEMSDWGARLTEGRARGVAVVESFGSFVAQVAEVSVGPDGA
PRVHKVWCAVDCGVAVNPNIIKAQMEGGIGYGLGAVLFDAVTLGKGGQIMQSNFHDYRSI
RINEMPDVSVEIIRSAEKPTGVGEPGVPPIGPAVANAWRKLTDAPVRQLPIVSIMSS
>A0A3G7WXZ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas orientalis|TrEMBL
MQLRINQKAYEVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAALVGREITTIEAIEADDVGKRVVAAWVERQVAQCGYCQSGQVMAATALLKHTPAPSKA
QIEAAMVNLCRCGTYNAIHAAMDDLAAGKETA
>A0A6N4WWI6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lentimonas sp. CC11|TrEMBL
MKTILCSRRDFLKATGLSAAGLVLGFRAAQAASPADSEFKPNAYIVISEASGVLLYIPIP
EIGQNIRTTFAMVLADELGADLNSVTLKQAPPQADIGHQNAGGSNSVRRQYLPLREAAAI
GREMLIAAAAKEWGAQPKDCRVDASIVYGPSDVSMPFTQAAKLAIGQPVPTSAPLKPASE
FKYIGQATRCLDTTDIVTGQMTFGIDAYPKELAYAVLLRSPVHQGQLKSFDASAAKAMPS
VKDIFQVGNAVAVIATNTWAAMNASRVVSVKWDEGENATLNTETLDQQRIDAVTSGNEIT
FKKGNFDNAYSNAAIQLESEFYIPTIAHATLEPPNCTAWFHNGRVEIWGSCQMLGRLHKQ
LPRITGLPHEKITYHQLRIGGGFGRKLEIDYVEEGIAIAKQVDYPVKMIFTREDDIRHDR
YRAPDQYKFRIGLSQSGFPEAIEEVNVLKPKKRASELARFFDTIAMKHTTVPSGLPSGWL
RAPGHNVTSFAEQSMIDIMAEKSGIDPIDYQLALHGDAETVRKLGWKNAPANIPEICELL
KIVKQRSNWKGDSNFGYGLSTFTGYGSYSAVVALVSKSGGSRPVERVYAAVNCGTVINPL
GAHAQVEGGIIDALGATLYQNITLKKGRVVQSNYHDFKLLRIAEHPEVDVHFVESDAKPQ
GLGEVSYPAMPAATTNALYAATGKRITKLPLRS
>A0A6C6YMY8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia mallei (strain NCTC 10247)|TrEMBL
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
ADIDAAMNDNICRCATYTRIRAAIHEAAATLKA
>A0A7Y9RQE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. IAR9|TrEMBL
MATVLTINGETKSFDAPPEMPLLWVLRDILGMTGTKFGCGIAQCGACTVHVDGKAVRSCV
LPVSAVENRAVTTIEHVGSTPAGAKVQKAWLDLEVIQCGYCQSGQIMSAAALLAATPNPD
DSDIDAAMAGNICRCGTYVRIREAVKQAANGRQS
>W6W7C5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. (strain CF080)|TrEMBL
MITLNINGKDHEIDADPETPILWVLRDTLGMTGTKFGCGAALCGACTVHLDGEAVRSCST
PVSVAEGAKITTIEKTTDGSDRIGAAVHAAWVKHDVAQCGYCQSGQIMSTTAFLTSLPKG
KQPTAEEIDTAMEGNICRCGTYVRIRAAIADAASTLV
>A0A7Y9WJN3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MQFELNGRPFSFDGDAQTPLLWVIRDHAMLCGTKYGCGIGACGACTVHLEGDAVRSCVLP
VSAVAGKSIRTIEALSPDGTHPVQRAWVAKDVPQCGYCQSGMVMAAAALLAQTPKPTDAQ
IDQAITNLCRCATYQRIREAIHVAAEN
>H0T4I2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MRSAVTLDRRGVLLGGGALIVGFALRDAAAQPAPNGVKRPGSLAHTPYLDSWIRIDASGE
ITVLTGKAELGQGMKTAVLQVAAEELDVPMARLKLVTADTGLTANEGYTSGSHSMQDSGT
AIRNAAAQARTLLIAQAAQRLGLSADQLRTDNGAVVAPDGTRLSYGELVAQDMLHVESAP
TSTLKQTASFKVMGKPLQRVDIPAKVTGGAAYVQDMRPDGMLHARVVRPPSYGAQLTALD
SAAVEAMPGVVKVVRNGNFIAVVANKEYQAIRAMIALAARSQWQENARLPAQADPRLLLT
SLPAQDSIILNIADPAVTGAKTIAASYTRPYQAHGSIGPSCALAQFADGMMTVWSHTQGV
FPDRQAIAEMLQLPPDKVRVIHVEGSGCYGHNGADDAAADAALIARELPGRPVRVQWMRE
QEHAWEPFGPAMLTQARASLDADGKIAAWTYEVWSNTHSMRPGGAGSLLAAQHKADPVAE
PAPKPLPLPEGGGDRNAIPIYTFPNAVVTHHFVKQMPLRISALRSLGAYHNVFSIESFMD
ELALAAGTDPVAFRLRHLTDARGRDVIEKAADAFGWSRHDKLPAGRGRGFAFARYKNLAA
YCAIAAEVEVNRDTGRARLARAVAAVDAGEIINPDGLTNQIEGGIIQSMSWTLYESVSHD
ATRITSIDWQSYPILRFNSVPDSIEVHLINRPGLPFLGAGETAQGPAAAAVGNAIANAIG
RRLRDLPLTRQKIKDAIQV
>H0T2D9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MTPASIRLTVNGRTHDVAAAPDTPLLHVLRNDLALNGPKYGCGLGECGACTVLIDGRAAR
ACVVPIEGCVGRAVVTLEGLGSRETPDPVQQAFITEQAAQCGYCLNGMIMTTKALLAIKP
DPSLDEIKQALRYNLCRCGAHVEILRAVMRAAGHTLEALD
>F3BGC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas distincta|TrEMBL
MIGTASAGLVMAFAPALFSGSLSAKESIAQQAFSPTIWWTMSTDGAVEVSIAKAEMGQHI
GTALARIVADELECDWDKVSITYVDTHEKWGFMVTGGSWSVFQSFKPLSQAGAAGRIALI
EAGAKMLGVPADKCRAEKGYIIAGEKSVSYADIVKKGEFNRTFTSDEVANLPLKPANKRH
LTGLKQDFKALDIPAKTNGTAVYGIDVEVEGMLYARPVIPPTRYGSTVTNVDDSAAKAIK
GYKGYEILIDPSNTVQGWVVVLADSYPSAIKAVDALKVSYKKGESANISEADIQKEGKRL
CEQRDSGTLFVDEGDIKKTQADASESLESMYTTATASHYQLEPLNAVAEFKDGNWIIHTG
NQWQSLTLPALAKALDIEQNKVIIRPYYLGGGFGRRLFGDWTVPAALTAKAVGKPVKLVF
TRADDSLFDQSRSASAAKMTASFDKNGTFTGMEHAFAAGWPTKAMAPGFLSPGVDGKGKF
DAFSASGADHWYSMSSHRARAINNEVAQSTFNPGWLRSVGPGWIAWSLESFIDEIAHKQG
KDPVQFRIEMLDGKGKQAGKAPESVGGALRLRNVLKTVSDKVASVKLAKDEGIGFSVSSG
QERTMPAWLATAAHVHVNRDSGKITLKKLYVVVDAGLIVHPDGALAQIEGSLLWGSSLAL
HESNTYKDGQVSATNFNTYLPLRMQDVPDMDIEFLQSDEFPVGLGEPGVIGVAPAIGNAV
FNAVGVRLRDLPMKPSELKKGLEA
>A0A6M4GZX4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MAKLNINGKVQDVKVEDDTPLLWALREQVGLTGTKYGCGVAACGSCSVHINGEVRRSCVT
PVGSLKATDKIVTIEGLSKGATHAVQKAWAEVDVPQCGYCQSGQIMAASALLAKNAKPTD
ADIDAAMTNICRCGTYQRIRKAIHRAAEIASAPKAKEGAKA
>A0A5M9I667|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas panacis|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAIEADEVGKRVVSAWVEHQVAQCGYCQSGQVVAATALLKHSPAPTTA
QIDAAMVNLCRCGTYNAIHAAMHDLAAGKESA
>A0A1R0MUF6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chromobacterium violaceum|TrEMBL
MKVSINGKAVELGSSPDTPLLWALRDELGLTGTKFGCGAALCGACTVLKNGLPIRSCVTP
ISSLAADDSITTVEGNADKVAQAVKQAWHELDVVQCGFCQSGQLLAATALLSANPHPSDQ
DIDLAMSGNLCRCGTYPRIRAAIHAAAKLL
>A0A484SPN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MRLSVNGQLHTVEAEPAAPLLFVLRNDLALNGPKYGCGLGECGACTVLVDGVAARACVMP
VRGVLGREVTTLEGLGDSACPGPTQQAFIECQAAQCGYCLNGMIMMIEALLRRQPAPDEA
QIRQELRHNLCRCGTHVEILQAARRAVTLHAQARETACAKRSGR
>A0A0K1ZN50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MITLDINGKPTHVDAAPDTPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCST
PLSAAAGKQITTIEGVDRARVGKAVQEAWRHLDVVQCGYCQSGQIMSAVALLESNHQPTD
ADIDAAMAGNICRCATYVRIRAAIHDAAKRLA
>A0A379KPX1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MELRINQKTYQVEADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIEADAVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPQPSDA
QIDAAMVNLCRCGTYNAIHAAVHELAQGEKA
>A0A6J5KBN4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia phenoliruptrix|TrEMBL
MTTFNINGENHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDKKITTIEAVGNTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAIKHAAKGV
>A0A291QM46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces formicae|TrEMBL
MPEHTFRLNGEQVTVDAADDERLLWVLRDILGVTGPKYGCGINVCKACTSHLNGRAANPC
SIPVKDLKPTDEVTTIEGLPATVGADLHPMQEAWLEQDVAQCGYCQPGQIMAAVALVRRV
AEDGRKVTDEDLDGIRNICRCGTYFRIREAIRAGAEKM
>G4STD2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MSTLSNLSMTRRQFLGTAAAGAGVFVLGISLPGCAKVDEQGEGVINAFIGIDENGVVTFQ
NPFIEMGQGTYTSIPAIMAEELDADMAMLKVVQAPHGPEYRIMFNNTTRFTGGSFSVRSS
YMTMRKAGATARAMLIEAAAGTWRVPPGECTTEPGVVIHRESGKKMTYGELAPLAAKLDI
PADVPLKDDASFRLIGKPIKRTDNRVKATGEAEFGIDIKADGLLYAAVKQSPVFGGSVQS
YDQDAVLKMPGVVAVEEIPNGVAVIADQYWRAKKALEQLPVTFDEGDNADFSSKSYLEKL
KAALNESGVRVENVGDADKALSEAAKTIEAVYHAPFLAHQTMEPMNCTALVTKDHCKVWA
PNQGADFVAKVAAEITGLKLDAIEVITPFLGGGFGRRFIMDYTAQAVTLAKKLPGKPIKV
IWTREEDTQHDHYRPMTAAKYRAGFDAQGNPLAIQITTAGEGPSGRLNPEFLKDPTIDES
IFEGGPHQPYAIPNKRAELVNVTVKPVPIGYWRSVGNSQNAFFKESFIDEMAHAAGADPV
EFRRNLLTEQPRFKKVLDTAAGMANWKSEAWKDENGIKHAMGVALHESFGSIVAQVAEVA
VDDGDIRVVRVWCAVDCGFAVNPAIVKMQMESGIVYGLSAAWSEEITLEKGRVTQSNFHD
YPILRPDQMPAVDVEIINSGEPLGGIGEPGTPPIAPAVCNALFKLTGQRVRSLPLSKYTF
>W6VSK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. GM30|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGAHRFALAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAANYGMPAFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFDVAPSTIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGATV
KSFEGAEALAVPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVDWDMGPHADLSSHGLLD
SFRKLAATPGTSASQAGDAKGNFDKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAEKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAGMP
VKTVWSREDDIRGGYYRSMFLHQARIGLDGQGLPLSWQHVLVGQSIMAGTMLEQTMVKNG
IDATSVEGVADSPYIKGLAHQQVELHSPQTGINVLWLRSVGHSHTAFVMESLIDEMATAA
GKDPVEYRRTLLKDHARHLGVLNLAVEKANWTAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTVKDGMVVQSNYHD
YQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVYALTGQRLRELPLQLSGV
>A0A6J4KZ28|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Gemmatimonadaceae bacterium|TrEMBL
MAITFKVNGKPRSVNVAPDMPLLWVLRDVLDLKGTKFGCGAAQCGACTVHVGGAPTRSCQ
VPAAAVQGADVTTVEGLSPDGTHALQRAWEELDVPQCGYCQAGQLMSAAALLAKNASPSD
ADIDAAMNGNVCRCATYTRIRQAIHRAAAMKGEARPVGGAASSGAAK
>W6W3P3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. GM30|TrEMBL
MELRINQKTYQVDTDADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIEADDVGKRVVSTWVDLQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHAAVHELAGKGDA
>A0A0E3V0Z3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polynucleobacter duraquae|TrEMBL
MADLNVNGKKYKVDVDPATPLLWVIRDHVGLTGTKYGCGIGQCGACTVLFDGQAIRSCAI
PVSAAAGKKIETIEGLEKNGQLSKVQKAWVDNQVPQCGYCQSGLVMATTALLRNTPKPTD
AQIDAAVTNICRCGTFQQVREAIHAVSKA
>A0A1X6YE02|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius gaetbuli|TrEMBL
MAGLKTIARRTFLIGSAAIVGGVAFGVYKYKTPPANPLLDDLPEGAAALTPYVLITQQSI
TLITPRADKGQGAISVQAALIAEELDVELDQIKTDPGPPSPAYYNTALSGDAVPFRSTDD
SVLAETTRAVMDAPIKFLGLQITGGSTTVPDGYDKLRMAGAVARETLKEAAAQIHGLDVA
ALITERGAVILPDGTRVPYQALASTAATLEPATEVTLRAPEQWRLLGKPMQRVDIVSKST
GTQDYGIDQDHPGILHAAIRLNPAQGGEMRGFDASEAEKMRGVVKVVPLPGGIGVIADNT
WRAFQAALAVEVDWGPAPYPAEMDGHWTALGESFTPAHQDSQFRDAGDVDAALSQGGDLA
VEYRAPYLAHAPLEPVNATVLVGEGRVDVWTGTQIPRFVQKNVALLTGIDAENVHIHALM
IGGSFGHRLEDDVVRHATTLAMAMPGTPIKLTYSRGEDMTHDYPRQIAMARGQGRVSNGQ
VETFDLGIAMPSVMASQMGRQGLPAAGPDLQIVAGAWDQPFDIANYRVTGYRAPELAPIS
SWRSVGASSNGFFHDCLLDELIHAAGADPLAERLRLCNHAPSRAVLEAVGEMSNWGGALA
ARQGRGVGFCLSFGVPCAQVVEVSETDAGIKIDRVFVAADVGRILDPVNFEGLVKGGVIF
GLGHAMNCEITYASGAAEQENFDSFPGMRLYQCPEIKVHGLESANKIRGIGEPPVPPAAA
ALGNAIFAATGTRLREMPFSKFVDFA
>A0A1X6YDV8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius gaetbuli|TrEMBL
MFRPEETAKRGRRVKLTVNGTGHDIKDVEPEMPLLWVLRDELGLTGPKYGCGIAQCGACT
VHIDGVAVRSCQVAAGDVWGAVTTIEGLGTPEAPHPVQAAWIEHQVAQCGYCQSGQIMQA
ASLLAETPAPSDADIDDGMSGNLCRCGTYPRIREAVKTAAAKLSGG
>A0A7W8L2Y5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia youngii|TrEMBL
MKLQINGKTYEVEADADTPLLWVIRDELGLTGTKYGCGIAQCGACSVLIDGAVVRSCVTP
VEGVAGRSITTIEAIENDEVGKRVVAAWVKHQVPQCGYCQSGQVMAATALHKQNPRPSDD
DIAAAMTNLCRCGTYNAIRAAVHEVAGGAPHTASSAAGVPGQLAAHPAGEPVAATTRIAL
ASIGAVSAPVRQGTVDEEQS
>F4CDM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium sp. (strain 21)|TrEMBL
MNRKEFISTTGQLFIGFHLLPFLCCTPSKGGAKIARAIDSNNIDAWLKLSDEGKVTLLTG
KMELGQGIRIALKQIAAEELDVDLSRIHIIIADTKRTPDERYTAGSASIENSGMSIRQAA
AEARYRLIRMAAEKLRSPFTSLIVNDGLVLDPSQPDKSISYWELLKGKAIQGTISGNAPL
KNPKDYRLIGKSVPREDIRTMVTGTSYYIQDLRFPDMLHARVVRPPSYDAKLLSFPEKEV
AKMDGIRKIIRNGDFLAVVAQEEYHAIRAWEYLRSFSKWKTGVLPSQQILFEDMVHRSKE
VKVVEAKGDTNKPNLTTIEATYTRPYHMHGSIGPSCALARWSSKGLTVWTHSQGVYPLRK
SLSDLVDLPEESIHVIGVPGSGCYGHNGADDVAADAVLISQALPESTIRLQWMREDEHCW
EPYGSAMRIQLNGSLHEGKISYLETQLWSDTHSVRPGGQASLLLAAQYIHPKKQAEKNGV
SGGAYRNAIPLYNTDSLKVTAYAFQGPLRTSALRSLGAYANIFALESFIDELASRGKQDP
ASFRLKHLNDARAIAVIKAVCNKVNWSQRKERKDYGFGLAFAQYKNHAAYFAVIAEVAVD
RSRKTFKLTKLTGAIDAGQTINTDGLKNQTEGGMIQSASWTLFEEVKYSADGIQSDTWES
YPIMRFSDVPETEVIVIDRPEEKPMGAGEAAQGPTAAAIANALFAATGQRLRNLPLRANK
LQW
>A0A0H2XU97|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia (strain AU 1054)|TrEMBL
MSRGLIEAGKVAGQAAGAGVSRRSFLKLGMSLGAAAGGGLLLGFSLPAAGDDARRSVIGG
DAAEPAQPGVFAPSAFVQIDRAGKITLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLD
HAPPNEKLFTDPLLGGQLTGGSTSVRYAWEPMRRAGATARTLLVSAAAKQWSVDPASCRA
VNGEVQHPPSGRRASYGQLADAAAKLPVPKDVVLKKPADFKLIGTPAKRLDSPEKVDGTA
QFGLDVRLPGMLYAVIVNSPVFGGTVASVDDTAARKIPGVRQVVRVDNAVAVVGDHTWAA
KRGASALVVKWNEGAGAKVSTKDIVADLAQAAVSGKGAVARKEGDVGHAFANAKTRVDAV
YEQPFLAHATMEPVNCTVHVRGDGCEIWVGTQVPTRAVDTVQQLTGLSPDKIVVHNHLLG
GGFGRRLETDMIDQAVKVGKQVNAPVKVIWTREEDIQHDMYRPYYYDKISAGLDANGKPI
AWQHRIVGSSLMARFAPPAFRNGIDPDAVEVSADLPYDLPNQLVDYVRQEPRHVPTAFWR
GVGPTRGTFVVESFIDELAAQTKTDPVQYRRALLGKAPRALNVLDVATKAAGWGPSLPKG
QGRGVSVMYAFGTFFSMVVDVAVDNGEVQVKRVVCAVDCGMSVNPNTIEAQVQGGIIFGI
TGALYGEITIEDGRVVQSNFTDYRMLRINETPPIEVHLVKSGEAPGGIGEPGTAATAAAL
SNAIFAATGKRLRKLPVGDQLKTA
>A0A0D1EJJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia aquimarina|TrEMBL
MTITTSRRAFLASAAALTVPLALPAAAQMTETLSPEQARWPDSFLRIGEDGTITCILPTC
EMGQGTHTGQAMILAEELGADLASVRIEMPRQPSDPYRLPFGQMRSVGSYGIRHFHDPMR
RAAAQMRMMLMQAAADRLGVPEHALAAEGGRIVHPETGETIPFADLVGEARLLPVPAEPK
LRPEAERTLTGTNVPRLDTPAKTRGEAIYAIDVTLPAMAYGAVRLAPVFGADVAAMDPAS
VQDMPGVIAVVQVPRGAVIVADSWWQARQAADALDITFTQTEHDMLDEATLQARIAEGLG
RDDVPMTLTRGDPSATLEGAGTVVEADYAVPLLAHACMEPITCTAQATAGRTELWAGTQG
HDWKRMMLERELGIPAEELFINTTYLGGGFGRKTWHHDAVQAVLASRSVGGRPVKVIWSR
EEDIAFGMYRQTMQARFRGAVDADGRITAMTVRVAGPQMGAAIVQENNMDPFSLLGLVDQ
PYAVPNYAVDHAVVDIPVPLSAWRAIATSFTGYWMESFVDELANAAGMDPLAFRLLNLPS
DSRARPVLERAAAMAGWDDAPPEGVHRGISVVGSYGSMVAQVAEVALDGERVSVPRVFAA
IDCGRAIHPGQVETQIQGSVIDALGPTLRAKITLEDGAAVQSNYTDYPLIRIDEAPSVAV
EIVETGAPLGGVGEPGVPPLAGAVCNAVFAATGRRIRSLPLSDHGLA
>Q13RB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia xenovorans (strain LB400)|TrEMBL
MLKRRTFLLGGAGAVGALLVGWSVLPPGQRLTTSMPLPAQGTQVALNGWVKIAADNSVTI
MMCKAEMGQGIHTGLAMLLAEELDADWSQVRVEDSPIDRIYNSVQNIIDDLPFRPDDDSA
IKRATVWMTRKVVSEAGTMMTGGSSSINDLWTPMREAGASARAMLIGAAAAQWKVPAGEC
RAEGGHVLHPSGHKASFGELSSMAAQQPLPRQVALKDPAGFKLIGKPLRRIEAASKINGT
ARFGIDALPDGLLYASVVMCPTLGGSVARFDATAAGKMPGFIKAFAVAPYNGGTGGVAVI
ADNPFRAMNAVTAVEVDWHDGPAAKLSNADVDRHLAQALDDGDGHAYYRLGDVDAALSRA
ARTVSAEYRAPYLAHGAVEPPNCTVQVTDGSAAVWVSTQMPALARHHVAKVLDLDADKVD
VQTLLLGGAFGRRLELDFIAQAAAIAREGGGRPVQTIWSRAQDFTHDFYRPACVSRLKAG
FDNDGKLVAWQATSASQAIVPESLARYYGVPRIPIDKTTCEGAFDQPYEWPAARVAHKIV
ELPVPVGFWRSVGHSHQAFFTEGFTDELAVAAGQDPIAFRAALLAQHPRHLAVLRRVAVL
SDWGHPLTHAADGAPRARGVALHEAFGSVVAQVAEVSIGPDKGIRVHRVVCVIDCGMPVN
PNLIRQQMESAIVFGLSTALQDEISLVNGQVQQKNFVDFPVVRINDCPVIDTDIMPSQMH
PQGVGEPGVPPVAPAVANAVFALTGQRLRSLPLKLA
>A0A2P9FEE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. MA5143a|TrEMBL
MARQLSRRKFVVYSLAASTLTVAAPLGCDATAAEGAEAADSAPRRPSDVLVTGTDEEMLV
LEVTKANRVVVRLPRVEVGQGVTTAVAMMIAEELDARLADVDIPLADARTKGNQFTGGSS
SVSSLYGPARELAALARAKLVTAAARRWRLPARTLKTRNTKVVAPDGRSATFGSLTASAA
RITRPAVSSRPKPASRHRVIGKATTRIDARDIVTGKAVYAGDLTVAGAKPTVVARPPTLG
GKAVSVDSRAARAMPGVHAVVEIAGGVAVVADTFHHAFTARDALRITWAPGPLAPLSDAA
IRSRLRAAVPRLGTPPRGSTQTEAEFEFAFVSHAPMEVLTAVADVRATRAEIWFSSQTPM
YARDSIASAVGLPEAKVKVHVVRGGGSFGRRLNHDAAIEAALISKAARRPVKLMWSRADD
LRHGRMRPASHHRIRASHARGRVVAFTHAMASVTETFEAQGPSARETAQGPGQGPAQGRV
TRAAARAAGPLPSDSGLYNFGRVSGDSGSVELAMPLGAWRSVDSGTMRTAEEIVVDEVAR
SLGKDPVAFRRTTLRNKAVKAVLDKVADAGDWGRTLPAGHAQGVAVHEEYGSRVACLVEI
DAADPENPRVTKVVMAADVGTAVNPRGLEAQLMGAAIDGISTVLRAGLHIDRGAVRETSY
ADFAYARQRHAPLLFEAHIMPSRREPGGAGELGVPAAAGAVANAYARATGTRPRRFPLNF
>A0A2P9FEH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. MA5143a|TrEMBL
MPSYSFVLNGKPVTVEAPADMPLLWVLRDMLDVTGPKYGCGVGVCRACTSHLDGEDVQPC
VVPVADCAGRAVTTIEGLADGDELHPVQRAWLDRDVAQCGFCQPGQIMAAAALLKKTSHP
TDADIDRIENVCRCGTYCRIREAIKQAAAQD
>I3XCS9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MVSLTVNGNQHQLDVDPATPLLYVLRDDLALNGAKYGCGLGQCGSCTVVVDGEAVLSCMV
PVMLLEGREITTIEGLGTIEKPGPLQQAFIELQAAQCGYCIPGMMMSAHALLRRSARPSE
EELREALATNLCRCGTHMRILAAIRRAGELMQAASLPGADEGRTG
>Q1D2Y3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Myxococcus xanthus (strain DK1622)|TrEMBL
MTKLLTLISRRSFLEGLNLSVGGLALGVFSGGLAAAASDASTAKGAPGLNPNVFVHVAPD
GAVTIVCARSEMGQGVRSSLPVLVADELGADMARVTVAQADGDKVYGDQNTDGSSSVRGV
YDDIRRMGATARVMLVAAAARRWKVKPEACEARDHAVFLRDGKRSLGFGELVADASRLPI
PKAKDVKLRPKSELRMAGRPMPLLDGPAYVTGTAVFGADIRLPGMLIAVVARPPVVGGKV
VRFDATRALAVPGVKKVLELPAPKPPYTFQFWGGVAVLAENTWAAMRGRDALDITWEDGP
NASYDSTTYREQLTASIREPGTVARNVGDIDAALASAARIIQAEYHIPHQSHVPMEPPVA
LARVENGTCEVWAPTQHPQAARGVAAATAELPEEKVQVHVTFLGGGFGRKSKADFIAEVV
WLAKEAGVPVRVQWTREDDVRHDYYHPVSAQQLTAGLDASGKVIAWRHRTAFPPIASTFG
QATRPSPSDLQQGVLDLALSVPNVRAETCEAPPHVRIGWLRSVYNIFHAFSVNAFVDELA
HLRGTDSRDMLLEVLGPPRKASLQELGITALRNYGASVEDHPVDAGRLRGVIERVTAMSG
WDARKANGRALGLAAHRSFLSYVAVVASVVKDDQGRIRVDEAWVSVDAGTILNPERVRSQ
MEGSIIFGMSIALHGAVTMKRGVTEQSNFRDLKLVRIGEAPRKIHVDIVPSELPSGGIGE
PGVPPVAPAIINAIFALTGTRIRELPVSRTLAV
>A0A2N9CUR1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MSRGLLEAGRAGAGVSRRGFLKLGMSLGAAAGGGLLLGFSLPAAGDDARRSVIGDDAAEP
AAPGVFAPNAFVQIDRAGKVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
EKLFLDPLLGGQLTGGSTSVRYAWEPMRRAGATARTLLVTAAAKQWNVDPATCRAANGEV
QHPPSGRRASYGQLADAAAKLPVPKDVALKQPADFKLIGTPAKRLDSPEKVDGTAQFGLD
VRLPGMLYAVIVNSPVFGGTVASVDDTAARKIPGVRQVVRVDNAVAVVGDHTWAAKRGAS
ALVVKWNEGAGAKVSTKDLFADLAQAAANGKGAVARKEGDVGKAFANAKTRVDAVYEQPL
LAHATMEPVNCTVHVRGDGCEIWVGTQVPTRARDTAQQLTGLPPDKIVVHNHLLGGGFGR
RLETDMVGQAVKVGKQVNAPVKVIWTREEDVQHDMYRPCYYDKISAGLDANGKPVAWQHR
IVGSSIMARFAPPAFKDGVDPDAVEVAAELPYDLPNQLVDYVRQEPRHVPTAFWRGVGPT
RGTFVVESFIDELAAQTKTDPVQYRRALLDKTPRARNVLDVATKAAGWGAPLPKGQGRGV
SVMHAFGSFFSIVIDVAVDGGEVQVKRAVCAVDCGMFVNPNTIEAQVQGGIIFGITGALY
GEITIEDGRVVQTNFTDYRMMRINEVPPIEVHLVKSGEAPGGIGEPGTAATAAALSNAIF
AATGTRLRKLPVGNQLKTA
>A0A385ZRD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces griseorubiginosus|TrEMBL
MPSYSFLLNGKPVTVEAPSDMPLLWVLRDLLNVTGPKYGCGVGVCRACTSHLDGEEIQPC
VVRVADCADRQVTTIEGLADGDRLHPVQQAWLDSDVAQCGFCQPGQIMAAVALLKKTSHP
TDADIDGIENVCRCGTYSRIREAIKKAAAQG
>A0A7W5HVN6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. Tn43|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATSALVLAASWGWQDALAGEKDKKFGADGMPNGWVDD
PKVYVSIAADGSVTVICNRSEMGQGVRTSLTMVVADELDADWALVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECRAQLHKVIHQPTGRELGYG
ALAAAAGALAVPARDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAVYGADVHFDGMLFA
TVARPAVYGGKVKSFDASAAMKVPGVIKVLQIESRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKKLEAASLKPGKVVRNTGSIDQAMSSADSTVEASYYLP
HLAQSPMEPMVAIARFKDGVCEAWAPSQAPQVSRERIGERLGIPFDNVTLNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAVHTRVGWFRSVSNI
PHGFAIQSFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTARM
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGALIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEIAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAQA
>A0A080M543|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Accumulibacter sp. SK-02|TrEMBL
MISLTVNGKKLSVDASPDTPLLWVLRDHLHLTGTKYGCGACTVHVDGAPQRSCAIPVSMV
AGRAITTIESADQTKVGKAVQAAWQKLDVVQCGYCQSGQIMSAVALLSTKRKPTDADIDE
AMGGNLCRCATYQRIRAAIHEAAKSLA
>A0A1J5RWR9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MIKLDVNGKVHELDLSPDTPLLWVIRDHLKLMGTKYGCGIAACGACTVHLDGQPVRSCQT
PVSSAAGSKVTTIEGVQGPEAKAVQEAWIAAEVPQCGYCQSGQIMAATVLLQQTPKPTDA
QITDFMNGNICRCGTYQRIRAAIHEASAALHKG
>U2WSD5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MRKNNDLTVRNFGCRLNALDGDHIRDAAHKAGLAQATIINSCAVTSEAVRQARQAVRKAA
KTKPETPIIVTGCAAQTDGEALAAMPEVSKVLGNEEKFLPSSYASQYTQQDETVQVSDIM
ALTRAVPRLNVPQQNRARAFVQVQTGCDHRCTFCIIPFGRGNSRSTPIAEVVENCQTLIA
SGHREIVLTGVDITSWGGDLTDSENEGLGDLVSAILENTPTLERLRLSSVDAVELDAKLL
DRVVRDKRVMPHLHLSLQAGDDMILKRMKRRHTREDAIAFCHEIKAKRPDMVFGADIIAG
FPTETDEMFENSLKLVETCEIVWLHVFPFSPRPDTPAAKMPQLSGETIRERARLLREASD
KVRQNWLETQIGSTLKGLIEKPGQARSETFAMIDFSNEEENNSPIGDIYNFEITGHDGSK
LIGKRLA
>A0A482ZV75|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MPCSSLDCSCDLQIDLSRLHWSRERLYISCSCDLQIDLSRLHSATIVELYISSCDLQIDL
SRLH
>U2XPH4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MLQKIIPVLVLAISGVLSLSNPALAGFDETVNAALAPISKAVSSFIFFSVPLNGADIPLI
VVWLIACSIFFTFYLRVLTPRNIITSLKMVRGDYADPNHDGQISHFKALTTALSGTVGVG
NIGAVAFAITIGGPGALFWIIVGGLLGASLKCAECTLGVKYRTKHADGSVSGGPMYYLEK
GLKEKNLPGLGKIIGGMYAAFIVIGCLGIGNMFQSNQAYEQLQLVTGGAEGFLFGKGWLV
GGIMAFIVGLVLIGGIQSITRVTSKLVPGMAGIYFIAALIVIGLNIEALPGVITDVVTQA
FYPAGITGGLFAVMIIGFRRSTFSNEAGLGSSSIAHAAVKTNQPASEGLVGLLEPLIDTV
IICPLTGLVILLTVFSPEMVGGDVQGVQLTSAAFETVIWWFPNVLAIVIVLFAFSSIIAW
GYYGQKGWIYLFGNNPAQNKMFLLIYCVFVLIGCTLDLGVIIDFSDAIVFCMALPNVLGL
YFLAPVVKREVCTYLEKLRSVET
>A0A7W5G3X6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas organivorans|TrEMBL
MHVLKQQAQSRAAAALSTVNVSRRGFMKGSAGLALGLYMAPLLGSKGSARADGDNGEFAP
NAFVRVTPDGEVVVIAKHIEMGQGTYTGLATLVAEELDADWQRVRVEGAPADTQRYQNLM
FGIQGTGGSTSIANSFEQMRKAGATARAMLVAAAAERLDVPADSLSVSHSKVVHEGSGRE
LDFGELAEAAADLPVPDEVTLKSPEQFTLIGKQHLMRQDSPAKTDGSARFTQDIQLDGML
IAVPAHPPRFGSRLASVDDAEALKVPGVVASVRFPSPTRGGDLVAVLASNTWAAIQGRDA
LTLEWDDSDAFTMGSEALEADYRERAGKPGETVTDRGDAASALEAADQVIEADYVVPYLA
HAAMEPLNCVVELGDDRCTIHNGEQWQTMDQQQVAQLLGLSPEKVIIHQLYAGGSFGRRA
NPISDYVLEAVAIAKAARDQGNDAPVKMAWTREDDTRGGHYRPFNYHRARLALDADGNLT
AWHQRLVGQSIMTGTPMESMMVKDGIDPTSVEGAADLAYAVPALNVELHTPKDIGVPVQW
WRSVGHTHTAFSTESLIDEAAVAAGQDPYQYRRERLGENPRWRGVLDLAAEKAGWSTPLE
SSAEGVKRGRGIAVHQSFSSYVAQVAEVSVDGDGKLKVDRVVCAVDCGVAVNPDMIRAQM
EGGIGFALAAALHSELTLEDGQVKQSNFHDFQVLRLNEMPEIEVHIVPSAEAPTGVGEPG
VPPLAPAVTNAIHAATGQRIRRLPIGNQLKA
>A0A1E7WLY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella phyllosphaerae|TrEMBL
MITLNINGKDVQVDADPSTPILWALRDKLNMTGTKFGCGAALCGACTVHLAGEPVRSCVM
PISAAVGQKITTIEAMESDKIGKAVQDAWVKLDVPQCGYCQSGQIMSATALLRTNKKPSD
ADIDSAMSGNICRCGTYQRIRAAIKDAASTIA
>A0A7Y9L1S9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MTTNRREFLKTTAVVGGGLTLGVFLPAQLDQAVAAGTLHTPNAWVHIADDNTITLLSARS
EMGQGVYTAMPMLIAEELGVDIRKIKVEIAPVAPVYTNALLGAQITGGSTSVRDGWEKLR
IAGAQARIMLVNAAAAKWKVDAAQLRAADGKVTGPGGRSATYGELAEAASKLPVPEKVTL
KEPKDFKLIGKPTKRLDTAHKVNGTAEYGIDVKLPGMVYASLEQCPVIGGKPVRVDAAKA
KAMPGVIGVVQIRDGVAVVADSWWRAKKAREALVVEWDEGPVARISNASMQDGIRNARDA
TIPIKKTGDATAALNGASKKLSAEYWSPLLAHATMEPQNFTASYKDGKCLVIGPAQFQQG
TQGNVASAIGLKPEDVTVKTTFLGGGFGRRLEYDFAVQAAEISKAVGKPVKLVWTREDDT
THDFYRPMALHRMAGGLDASGKPVALTLQLTSQSITQRAFGLPKGTLDPFMAEAAVVGYD
IPNMTQELIEHDSGLRVGYWRSVSHALNAFANESFIDEMAAAAGKDPYQFRLALLGQQPR
FAKVLKLAAEKSGWGKPLPKGHHRGIALMEGYDTYMAQVAEISVDKDQAIKVHHVWVAAD
LGHMINPDTVEAQIQSSIAFGLSSALGAEITLDKGRVQQTNFHDYPVLRMNEMPKIDVTL
VPSTEKPGGIGEPATALIGPAVANALFAATGKRVRQLPLSAEHIRSA
>A0A0P1GTD6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassobius mediterraneus|TrEMBL
MKLIVNGQEQQVEVEDDMPLLWILRDELNITGVKYGCGISACGACTVHVNGEAMRSCQVT
ADSLEEGDQITTIEGLGTPPALHAVQAAWVEHQVAQCGYCQSGQIMQAAALLSETPNPSD
EDIDDAMSGNLCRCGTYPRIRAAVKTAAKNMQEA
>A0A0P7ZZT8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Erythrobacteraceae bacterium HL-111|TrEMBL
MNLSRRGILAGAAAGGGLLVAWWLLPRAHHNPLTPGPGEHVFGAWLRIGEDSVVTVAVPQ
LEMGQGVTTILPQLVAMELGADWRQVAIEPAPPSGAYANLPLAEKWAPLWDPLAAGLSEP
TDALLAARFANAERFCATAEGTTLSAYEAAARAAGAAARAMLAQEAAERWGTAWEALRVE
GGIVRGGDGRSATFGELAAGAAVRAVPDPAPLRPEAPREDPHEDPLGRFADAAPPFPRID
LPAKVDGSLQFAGDVRLPRMLHASIRHGPNAGAELTGFDEAAGYRMPGVVQVVAGRRWLA
ALAETWWSAERALEAMDPRFTAAFPASSVEVATRLGLMLESGPSFRIAETGFGAEGMTRV
DIARRYEVEPHLAAPLETASATARLSGGRLELWIASQAPESARAAAARAIGLAVEDVALY
PVPAGGSFDARLEHDHAIEVALLAREAAPRPVQLTWPRASELAHARPRPPAWLLLGAQVQ
QGAPGSPGTGGAIDALRVRIACPPAALEFGRRLFGGLTPWAAIRETEGRKDPLACSGAVP
PYRLPSLVVEHVPVEIGLPVGRVRGNADGCTAFAIESFIDEIARRHGREPLSFRMAMLGS
DIRLAACLQRAAQLGGWDGGAAGSGQGLACHRIGDGPDAPRIACIATASGGESGVRVTRL
SAAVDIGRIVNLDIARQQVEGGLVFGLGMALGRAPRWRAGLPASEAYADLELPTLADCPE
IKIDFIASEAPPADPGEIGAVVAAPAIANALFSATGLRLRRLPLLSDGI
>A0A3S4Y4X1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MNLRDHELAALGEQPVNLSRRRFLLAGGSLAGVLVLGVGLPVGQGRAQTAQASPAPGTRV
PAFLEIRPDSSVKFLSPFIEGGQGIFTAMAQIVGEELDADPATFIVENAPAGSQYQVMDS
GMRITGGSQSVRSSYTTMRRLGALARQMLLQAAAAQLSVPVEQLHTEPGRVIHALSGRSL
SYGELAARARDLAVPSPDSVTLKDPARFRWIGKPVQRLDMHEKSTGKAVYTIDCRVDGML
HAAVQHAPRLGLHAGQLRNEEQVKAMKGVHSVHVLPGAVAVVAERWWQAKRAAEALQVEW
LEPDAPDGNYMPADFSSEAFAAALAQEPGEGEDAEVKGDSAQAMSAAQTTLSATYHSQYL
NHAQLEPPSALARFNDDGTLELWIPNQAPEMFQADVAKRTGLAPEKIIIHSPLLGGFFGR
HFVYDTAMVYPQAIALAKAVGRPIKLIWSREEEFLRDTHRPMAAVRFRAGLDAEGYPVAL
EAISICEGPTEAQTGKHGDQLDPSALEGLTGKAYAIPNVRIAQIYKKGPVRLGYWRSVGN
SMNDFLYECFLDEIADKSKLDPFALRLHLLQGNQRLTTLLNAVAEMSGGWQAGPYTAPDG
SRRARGVAMASPFGSEAAAIAEVSIEQGQVRVHQVWEAIDPGSIVNPAIIEAQVNSAVAL
GLSQVLLEESVYEKGQPVARNYDMYPILPPSRMAQVQVRIIESGAKMGGIGEPPLPAIPP
AVANAVSRLTGERIRSMPLSRFNFS
>A0A7X5Y4J2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kaistensis|TrEMBL
MARMRVNGQALEFALDPATPLLWALRDAANLTGTKQGCGGTGQCGACTVIVDGSAALSCT
LAIGTLEGADVTTIEGLANHPLTLALIAEDAIQCGFCLPGFTCAVAALLQQSPRPAAEQI
DALPNRCACGMQPRLRRAIERVAGAGAPEPSPTPPAPPQTPEIVSPPR
>B3RAI1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MSPLYTSRRRFLHAAGAVPAALVLGFHLPLAKAADAAAPARDPDDVNAWLRIDADGSVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQSWRVPVAQCRAVQGVVRHEPSGRTLGYGALAAQAAALPR
PANVALKDPRDWTLLGHATDRLDIPQKTRGAAMFGVDVKVPRMLVGSVTACPVFGGTLRQ
VDARPALAVRGVRRVVPLDDAVVVLADSYWTARKGLAALQPDWQLPQGQLAGDAALMAGY
REAARQASAVALRHGDPDAQMQGAPAFTAEYDVPYLAHATMEPMNATADVRADRAEVWGP
TQVCGEIAQRLSGVLGMPAARIAVHGTFVGGGFGRREEFDVFVQAALASRAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAADAPGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHLAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAGADPLQFR
LGLLADRPRPARLLQRLARHIGWGSAPAGRCHGLALSQAWGSLCATAVELSVQGQRITLH
RIVNAIDCGVVINPATVERQLEGASIWGLSAALSGTITIADGRVQQSNFHDYPLLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGHRIRSLPLARHGFELV
>G0AU70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica BA175|TrEMBL
MSTFTAVENISRRDVLKLFGAVGGGLALGASGLTWSPMALAQDKEARLNLFIAIGEDDKV
YLTCHRSEMGQGIRTGILQVLAEELEADWDKIVPIQGLADKRYASQNTDGSRSIRENYDR
MRQMGAMARTMLEQAAAARWKVPVSEVHTADHKVLHAKSGRSAKFGELALAAAEQPVPAV
ESLTFKEVKDFKQIGASRQIVDMDAMLSGSAIYGYDIKLDGMLYASIMRPPVLGSDVASL
DDTAARKVTGVVDVHRLPAAKGAPAFQALGGVAVIATNTWSALEGRKALKVTWTQADNSQ
HDSSLYLKQLVERVQQGGKVVRQAGEEIKNWPEANTLKAVYTVPYLIHSSIEPPVATAHV
TEKGCEIWASTQTPQSTQQNVAAALGMEEDAIKVNVTLLGGGFGRKSKPDFSVEAALLSK
QFKRPIKVSWSREDEIQNGYYHAISAQSYQALFDANNKPTALLARTGFPSISSTFAEGVE
YPSGGELDLGFVDVPFALPNLRYEAVKAQAHSRIGWMRSVCNIQHGFSVGSFVDEMAHRS
QVSCPAMWRSLLGEARRETFTDQQFKYGNYGEDLDRHPVDVSRYFGVIDAVEKAQAKAPK
AGKNQGWGFAVHRSFVSYVAVAMLVEVSEDKQLKVLNAIAAIDAGTIVNPDRVKAQTEGA
IVFGLSLALMGEITYKEGKVQQSNFHDYPLLRIPQTPDIEIIIIESDAAPAGVGEPGVPP
VAPSLTNAIFAATGQRIRDLPVNKLLRV
>A0A7Y9DT62|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinomycetospora corticicola|TrEMBL
MPTHRATTTRSRPTTEPAHRADVKRRSFLGLLVAAPVLVTAAEIGRQTIFESVPNASAVA
LPSAPQPAELYDLLDVIRDSARPTANLITVKVNKDGTVSFAIPRSENGQGIITSTQMIIA
EEMNLDPDQVVVTLADARPELVFNQLTGGSSTTFSTYTPIRVAAALAQGRLLGAAANELD
QDVSVLTSRQGLITGPNGKSLPFGDLTAKAAAPVTEAANVVLKDREKFTVIGKNRTKSDA
LAMVTGKKKFTTDLKIPDALPTVICRAPDLNGFPRSVGNLEAIRAMPGVTDVVKVGTGVA
VRAKTYGQAIDAVNALEVRWAAGTVAGEDDESVLRKLRRGELPLAVPKGVGTTLESDTVF
YFRSNSSLETNCAIADVRANSATIWGPSKSPIAAQAEIARKIGVPQNAVTFHVMEGGGSF
GRKLFFDAALEAAEVSKAMGKPVKLMWTRSDDSRQGRVHPMATTRIRANVAGEAVSSFEI
RHTSVATEVNPGLSEAITANAQKVPGGNLTVSESIFVTTQVTPYNFGVSTNFLSEVDMRF
NTSSMRNIYSPDVATARELMVDRIAGQMGKDPYEFRSEFTKLERWKKVVDRAAKEADWGK
SMADGTAQGIGMHVEYKGVACAVVELDCRPETVNREIRSARTGPRVTKVTYVVDVGLVIN
PRGVRAQMMGGINDALAMTLTSSLHLTDGHFVEASWDNYFYTRQWNTPPEMNIIVIDDSD
APEPGGVGEFGVAATCGAIACAYVRATGKTPSYFPLDHKDPLPFTPYPTSPPVPPSPVNG
LETTF
>A0A7X0JSM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoteredinibacter isoporae|TrEMBL
MIEFQLNGEPVSVDVPADTPLLWIIREHFQLTGSKFGCGMGLCGACTMHVDGIASRTCIL
PVVAVAGKSVTTIEGLGDAEQLHPVQEAWLEHNVPQCGYCQPGQIMSASALLATNPKPSD
SEIEAAMSGNICRCGTYPRIRKAIKSVAAVQQFDPAEQAAGGDA
>A0A238KQ96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actibacterium lipolyticum|TrEMBL
MSRIGSIARRTFLIGSAAIAGGVAFGVYAYKQPVRNPLTDDLAEGEAALTPYVHIDQTGV
TLITPRTDFGQGAYSVQAALLAEELDLAWEDIRVDPGPPSPAYYNGKVAAEGFPFPATDT
GFVAKNARAFGDVVSKFMGLQITGGSSTVPDAFEKLRVAGATARQVLLEAAAQVTGIAKE
TLSTKDGSVVLPDGTMLSYSELAPVAAGIQPPREVALKPESEWRYLGKPMTRLDTLGKVT
GTAQYGIDMTMPGMVYATVRTNPRLGGDVNGFDATAAETANGVLKVVPVTGGVGVIANNT
WRAFQAAEAIEFDWGPAPYPADMEAMWEKVGTSFSKDRKDSRFKNDGDVEAAFESADTVL
EAEYRIPYLAHAPLEPMNAVVQLKDGRLDIWTSTQIPIFAMAAAAEVSGLDAENIHLHVQ
ISGGSFGRRLEDDFIRQAVELAQAVEGVPIKMTWSREEDMTHDFPRPMQMARARGVVKDG
HVEAYDLGIAAPSVASSQMGRLNQSLPGPDIAIIAGAWDQPFAIPNYRVTGYRVPPLVPV
SSWRSVGASGNGFLHDCFLDELIHAAGADPMEERIRLCWHAPSRRVLEAVAEMSNWGNDL
GPDRGRGVAFTLSFGVPTAEVVEVTNTPDGIRINKVYVAAEVGKVLDPVNFENQVQGGVV
WGLGHAMNCELTYDDGMPEQTNFHDFEGMRLYQCPEIEVRGLETTDDIRGIGEPSVPPAA
PALANAIFAATGQRIRELPLNKHIDFV
>A0A7W4VBZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus alkaliphilus|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQPAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLEHVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAARRLGVDADRLEAADGVLRVPGTQLSIAYAALV
AGEHVELPLAEDVPTKPVDAYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLAVDRDSVRDVPGLVEVVVQGDFVGVVAEREEYAVLAARRLRVRW
KPVPPLPALDDPEPALRANPATRRELLSEGELPAGGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRALGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGAGGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRMLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDERAADLLRAVADAAGWQRGAAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIDVVLMPRQSEPPLGAGESA
SLPGAPALANALFDALGVRLRRPPFVPETVLAAMASGNV
>H0SPN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCIT
SLSDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNQNPKPSHD
QIRDAMSGNICRCGCYQRIENAVHLASTGV
>A0A375JDE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MDNIARLSRREFLRGSLGLMTLAVTSGGLVSVAHAADPAPKKFGADSMPGGTVDNPLAFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVVQAEADETRYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPVSEVRAVQHEVVHQPSGRRLGFGELAAD
AARQPVPKGDALRLKLRAGFRYIGKNAVRPVDQEAIGSGRAVYGMDLRLPGMVYAVVARP
PVVGGKLRRLDSRKALAVPGVLKVVEIPAFQGAPAFQPLGGVAVVARNTWAAMQGRAALE
IEWDDGPNGSYDSTAYRRTLEAASRAPGKAMRNQGDAQRAWDQAPPAERLAADYYVPHLA
HTSMEPPVATVRIRGGSAEVWTSIQNPVAAQTAVARRLELKPGNVRVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPEGTPVKLVWTRDDDIHHDYLHTVSAERLEAVIDRQGQVKSWLHR
SAAPTIASLFTEGAKGQQIFESAMSAINMPYRIDNVRVETAEVPAHARVGWFRSVANIPH
AFAAQCFIAELAHRAGKDHRQFALDLIGPARKIDPGTLADTWNYTESPERYPYDTGRLRG
VIEAATRGAGWGRKLPKGHGLGLAFCYSFMSYTATVVEVAVDAKGEVRVVSVDMAMDCGP
QIHPDRIRAQMEGGAIMGLSLALASEITFDKGRVMQSNFHDYEVLRHHASPRVIRTHLVN
DNHDLPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVA
>A0A375IEQ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNPGEARADADVATMDRRSFLKLTGLAGGGLALGVAPLAQAQEGNK
PKAAPAAPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVVT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKSFSADKARAVRGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALELQWEDTGSKVSSQALFDEYAKLAGQPGTVARAGEGAGGGDIAAAIQRAPRRIEAD
FRFPYLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLN
TMMAGGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHR
ARIGLDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVH
HPQVDVPVLWWRSVGNTHTAFVKETLADEMAAAARQDPVAFRLARLDEKKHARHRAALQL
AVEKSGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNP
LSAEAQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDFPPPRITDAPVVDVFFVPSQDN
PTGLGEPGVPPIAPAVANALFTLTGKRQRQLPFVLA
>A0A375J5C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLSMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>S2DHZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)|TrEMBL
MADLIKTNRRDFLKIAGTAAGGLFIGFYWSGCDSPKMQVLSDDEVLAQAHNFNAFLSISP
SGDVVIYSPNPELGQNIKTSFPMVVAEELDADWEKVRVFQANLDNDKFDRQLTGGSGAMP
HSWERLRKAGATARHLLLVAAASQLEVDMDELATEKGEVIHKKSGKKIAYGDLVADASQL
EAPEDVSLKHHKDFKIIGTPVKNVDNKAMFTGKPLFGLDFYREGMVNAMIQRPPFGMKIK
SVDDSEAKKVPGVTDVVTFNNNVAIVGNTTWPLLKAKKLLKVTYEPDGTVESTEDHDRLF
VELMDKGKAQVMRKDGNVDQAFSKAAKVVSAEYQCPFLSHSPMEPQNFFAHVKGDKVELV
GPTQTPDRARMETAQLLDIPTENVSVEITRLGGGFGRRLRADFVVEAAELSKILNKPVKV
TWSREDDMTGGAYRPAVRYKFQAALDEEGNMIGYKLRGVGINAGNTTRENNFPSGSVDNL
LIESVNHSSPITTNAWRAPITNFLAYAEQSFIDEVALAVDKDPVKFRLELLDRAKNNPVG
EIHYDVDRMKTVVETAAEKSNWGKDANVMQGFSVYFSHRSYVAQVANIEMENNQPVLKKI
TAVTDCGIVVNPTGANQQVRGGIVDGMGHAMFTNMTFKDGLPTQKNFDTYRLIRMKEVPE
VDVHFIDNGIDPTGLGEPALPPTGGAIANAIYKATGKRLRSQPFIEQKEFSEFNLEIKRV
>A0A238D510|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thiomonas delicata|TrEMBL
MIKLDVNGKVHELDVSPDTPLLWVIRDHLKLMGTKYGCGIAACGACTVHLDGQPVRSCQT
PVSSAAGSKVTTIEGVQGPEAKAVQEAWIAAEVPQCGYCQSGQIMAATVLLRQTPKPTDA
QITDFMNGNICRCGTYQRIRAAIHQAAAALHKG
>A0A6V6ZL12|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF57|TrEMBL
MSLTLKLNGQTHTVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLNGEPVRSCQ
TYIEDVEDAEITTIEAVGDDKIGAAVQQAWVELDVVQCGYCQSGQVMSAVGLLSENSKPS
VEEIDEYMSGNACRCATYQRIRAGIQRASEILEA
>A0A4U9W0D2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium thalpophilum|TrEMBL
MKILAPFQKKKTATVASEIFGVSRRDFIKASGLLTGGLLLGVSFFSCDDKGKKVATVAPN
VYLSIGSDGKVTIIAHRSEMGQGIRTSLPLIVADELGADWSKVEILQAEGDEKKYGNQNT
DGSFSVRMFYKPMREAGAIARLLLIRAAAKEWQVGVEECDTQKGQVVHSPSGKKKSFGEL
VEIAQSLPLPKVSEVRLKDKKQLTMVGKETPIIDLHNIVTGKAVFGIDAEVEGMKIAVIK
RCPVVGGTVKSFDDSKARNVPGVLKVVVIKGAGLPATLKKPLSGVAVIAENTWAAIKARD
LLEVEWDLGPNADYDSARQIEELRQEMAKEGTIRRQRGDFKAAKAGAKKVIDHTYVAPYL
AHATIEPPCALAVVKNGSCEIWACTQNPQGARDAVAEEIGIPVEKVKMNVTLLGGGFGRK
SKPDFILEATILAKESGYPVKVQWTREDDIRHDYYHALSVQRIVATIDSQNKLSGWSHHI
ANPSISATDDMKVVQPSDGELMLGASDFPYDVPAISLETHDAKAHLRIGWLRSVRNIPQV
FAIATMMDEVAEARGMDPIANALELLGEDRHITFDQELVKTTYPNYGENIADYPWDTGRM
KRVIERVAKESGWGRSLPKGSALGFAAHKSFLTYVACVVEVQVDANQNISIPNVYYAVDC
GLPVNVDRIKSQFEGGAQFSASLALKSTISVKQGQVEQSNFDGYQIVRMPESPKEIHVYI
MESDAKPTGVGEPPVPPFTPALCNAIYAATGKRIHTLPIDLKA
>A0A846UZJ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. SG609|TrEMBL
MSRRTDTPALPQRRRFLQVLAGTAGALIVGVRYAEAGDAPVPPAMLGDALYGLGAYVRID
ADGNVLIGARDPDTGTGVATSLPRIVADELDADWSRVSVVPLGLGVENGNGEPRWSYGHQ
LGGTGSSISAAWTDLRQAGALARWLLMQAAARRLGVPADRLRTQGGAVISPDGRRFDYGS
LAEAASKVAPPTAPVAVKTPDRYTLIGQPAGDVDARAIVTGQTQFAIDSYFGDALVAVLV
HCPWIDGSLVNKDFREAEAVKGVFKVVELKPEPGLLPGETPLAPSVAVLAEDTWSALQAR
ARLKLEWKPGPSGSESSAALEQQATELVSAKTPSAKELAANPASQPIAPTTRVRNDGDVD
GMAKKAARRVDATYVQPWLAHATAEPMNCLVRVDKDRAVLVAPTQAPQRAWSVVQRLTGF
KPDQIEIRVPRVGGGYGRRLDHDFVAEAVMLAKLADRPVRLLWTREEDLAHDYYRSASVH
RLSATLDAKRQIVTWDQRMASASALARRGAPEQRLWTSEVDVNQLPAGLVPNYRSDWYAL
QSALPRGPHRGMPHVANAFAVESFVDEIANALKEDPLATRLRLLGDARQVPLQGGGTFDT
GRLLNVLKLVADRIEWKNWLRTVNGLGIACWHMDGAYVAHAVETSLQGQKLNIERVVCAV
DVGRVINPLGLEGQIAGATLDALSAALNLAVTFKDGQPQQRSYKDYPLASMAQLPDAMDV
IIVPGDRDPAGASFLAMPTAAPALANAVFRVSAVRVRRLPLMRELLRLL
>A0A2R8AHK3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aliiroseovarius pelagivivens|TrEMBL
MGRIGTIARRTFLVGSAAMLGGVAFGYYKYKQPVANPLEDDLAQGEAALTPYVLINADGV
TLITPRADKGQGAYSVQAALIAEELDIELDQINVDPGPPSPAYWNTALADEGVPFPSTDR
GMAAETMRGFMGAVIKLMGMQITGGSTTVPDGFEKLRVAGAVARETLKAAAAEMSGLAVT
QLKTQRGAVVLPDGKRIPYEALAAKAAEIDPVTDVTLRPSTQWRLVGKPMQRVDMVAKST
GTQSYGIDMRMEGMVHAAVRVNPRKGGEVISFDASEAEGMRGVQKVIPVTGGVGVIADNT
WRAFQAVDAIEVEWGAAPYPAEQAEHWKVLANTIDAGDADATPRDDGDVDGVATTVEAEF
RAPYLAHAPLEPMNATVLVADDRVDVWTGNQIPRMTQASVAKMTGVDVDDVHVHILMMGG
SFGHRLEDEVVKRATELAMAMKGTPVKLTYKREEDTLQDFTRPIALMRGRGAVADGKVTA
MEIKVASPSIMDSQMVERQGFPVPGPDTTITQALWDQPYAIPNYRVTGYRAPKLGPVSSW
RSVGASQNGFFHENFLNALIHAAGADPVEERLRLMTDDPSRKALEAVAEMSNWGGELAPG
RARGVAFCLSFGTPCAQIIEITNGEDGIKLDKVWVAAEVGKVVDPVNFENLVAGGVIWGL
GHAINSQITYAAGMAEQENFWDFEGLRNYQAPEIIVRGMENRDYVTGVGEPPVPPAAPAL
AEAIFQATGERPTEMPFGERFGFV
>A0A380B4I6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MNLPEVPLTRRRFIVGASALVIGAYLPSTGALARANSATAPENNPHAANAFVQIDQEGIV
TVISKHTEVGQGVYTGMATLVAEELDADWSQVRVVAAPVDTNVYKNLSFGFQGTGGSSSV
ANAYEQMRRMGAMARAMLVQAAAQSWKTSAQEITVQAGKIRHAASGREAGFGEFAVLASQ
LPPPDPATLTLKDPANFTLIGKASGLHRVDSLAKTNGSAQFTQDIHEPDMLTVTIKKPPR
FGGKVASFDASRALAVAGVVAVKQTDTGVAVYAKNTWAAIQGREKLQVEWDDSQAERRNT
EQIFAEFRQVAQKPGAVAKSHGQPDEVFDKADKVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDHQQLCDLFQLPPEKVEIETILAGGSFGRRIDLGNPKLGPDLAADM
AAAAKAIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVGWSDTVVGHSWTLN
SAMTALVVNGVDQMMIEGASEVPYTFESFRCDAHIVPGKVPTTSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPREAGVLRAVAKAANWQGAKVVDGRARGVGVAKAFNT
RVAQIAEVSIGEGGIPRVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSIALYGNITLKD
GVVEQSNFNNFRPLRIDEMPEIEVIIVPSSEAPTGVGELGVPTIAPAVGNALALLGRSRS
SLSLPLHRPNSDASV
>A0A0P8D6S5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Porphyrobacter sp. HL-46|TrEMBL
MAIGFTVNGKQVSVEAEADTPLLWVLREDLALTGTKFGCGIAACGACSVHVDGKLARSCS
VPVSDIAGKAVTTIEGLKGDDGTLHEVQQAWIDAQVPQCGYCQSGQIMAAIALIERTGTP
SDAQIDEAMTNICRCGTYPRIRAAILAATGTAAAAVQGEA
>W2UEU2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gammaproteobacteria bacterium MOLA455|TrEMBL
MISFQLNNSSVQVDIDPDTPLLWVVRDHFKLKGSKFGCGMGLCGACTMHVNGEAVRSCTL
PISAVQGAAITSIEGLGTPDNLHPLQQAWVEYSVPQCGYCQSGQLMAASALLAKNPNPSD
DDIEMAMNGNICRCGTYSKIKLAIKSGAEAMRAQGNVVEIFDPVMANKEAS
>A0A7W5QQ87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. BK369|TrEMBL
MIELTVNGQKRQIDADGDTPLLWVLRDDLGMTGTKYGCGIAQCGACSVMIDGTVTRSCVT
PVESVASAQITTIEAVEADPVGARVVEAWVKHQVPQCGYCQSGQVMAATSLLKQKAKPSD
ADVEAAMTNLCRCGTYNAIKAAVRDVAGLAATQEHGA
>A0A388RIT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MIGWSLLPPRQRMVGGEPLAVRDGQFALNGWVKVGSDNTVTVVMNKAEMGQGVHTGAAML
LAEEMEADWSQIRVEPSPIDNLYNNIEGVVANLPFRPDDNGWPRRAAAWFTRKGVREVGM
MFTGGSTSIRDLWNPMREAGAAARMMLCAAAAKQWDVKVEACRAQAGKVVHPSGRSATFG
ELAAAAAREDLPGKVELKDPGSFRLIGSRAARLDTPAKLHGTARFGIDVVAEGMVYASVQ
MCPTLGGKLQGAPADDVKKLPGVLDLVELPPFPGGSGGVAVIASDAWIAMEAVEKVPCKW
DAGEARNLSSAGIRDTLVKALDDANPRVWYEHGDGRAMKQGKPAIQVMYSAPYLAHAALE
PVNCTVLVQEDRAVVWAATQMPGLARRCVAKTLDLDTDKVELRQQSIGGAFGRRLEVDFI
CQAAAIAAKRKGVPVQTIWSRPEDMRHDFYRPASVSRFEAWLEGNRKVIAVRNMSASQSV
LESTAKRNFGLPDIFLSRLDKSTAEGAFDQAYDWPEVWVGHRTVDLAIPVGYWRSVGHSH
HAFFMESFVDELAVALSKDPLDYRMSLLKDDRQRAVLEQARKMSGWGQPLRKQPGVGKVG
RGVALHESFGSVVAQVAEVSVDNAGQVRVDRVFCAIDCGMPVNPTLIEQQVEGGIVFGLS
AALWQKITLEQGKVTEDYYTAFPAMRMRDCPDIQVHVMPSTGTPQGVGESTTPPIAPAVA
NALFNATGERLRDLPLLKTLPPSGACDVRQSDQCQR
>A0A388S0B3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MSATRKEAVQYASSAASISRRQWLKMALASGLAIAVSLEGVVIARRFRSGKFGGDGMAGG
LVDSPLIFVSITPDGVVSVVCHRSEMGQGVRSSIPLIVAEELEADLTRVRVVQADGDEQR
YGNQNTDGSRSIRHWLMPGRRVGAAARRMLEVAAAARWNVPIADVRARNHMLVHVPTGRT
LGFGDVAADAMRQPVPAASELTLKSDAQFRYIGKENTWLIDGHDMVHGRAAYGIDTRLEG
MVYAVVARPPVLGGRVKRYDATRALQVAGVLRVIEIEPSPPPAGFNPLGGIAVIARNTWA
AMKGREALVLEWDDGRNAAYDSEAYKSTLEKAARAPAKVMRNDGDTTQALAQANRRVEAE
YYLPHLAHASMEPPVATARIVDGKCEVWAPVQAPQSARDAVAARLAMKKDQVAVHVTLLG
GGFGRKSKPDFAVEAALLSQAMGGKPVKLQWTREDDIHHDYFHAVALERFEAALGEDGKP
VAWLHRSSAPTIGSTFTAGQKGLSPGEMGQSAINIPFQIPNIRIETTEVDAHTRIGWFRS
VSNIPHAFGVQSFVAELAAAAGRDHKDYLLELIGPARRISPRELSDDTNYGEDPERYPFD
TGRLRGVIEMAAKAARWGRTTPEGRGIGIAASYSFMSYTAAVIEVTVDKRGALRIESVDM
AIDCGPQVNPDRIRSQLEGACIMGLSLALYGEIGFKHGRAVQSNFHNYQVLRHHETPRSL
RVHLAPPDMSVAPGGVGEPGLPPIAPALCNAIFAATGRRIRNLPIGQQLSA
>W0P6F9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Advenella mimigardefordensis (strain DSM 17166 / LMG 22922 / DPN7)|TrEMBL
MITLEINGSKHEVDLPEDTPILWALRDHLGFTGTKFGCGMSLCGACTVHLDGAPIRSCVT
PITAAAGKKIVTIEAVENDETGKAVQKAWVEMGVPQCGFCQAGQIMSATALLKKTPAPTD
AEIDAAMSGNLCRCGTYTRIRSAIKNVAQAGGAK
>W0PE84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Advenella mimigardefordensis (strain DSM 17166 / LMG 22922 / DPN7)|TrEMBL
MSTLNINGSDHTVDVDPGTPVLWALRDSLDMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PISAVQGKKITTIEAVTDGSDAVGAAVHAAWVKHDVAQCGYCQSGQIMSATAFLKTRPKG
NPPTAAEIDAAMAGNICRCGTYTRIRAAIADAAQTLA
>A0A6M4H7L4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter palustris|TrEMBL
MVSITVNGQPLSFDGDPEMPLLWYLRDVLQMTGTKFGCGMALCGACTVHVDGAAIRACLT
PIGTVAGKKITTIEGLDPNGKHPLQVAWRDQGVPQCGYCQSGQIMQAAALLAANKSPSST
DIDNAMAGNLCRCGTYPRIKAAIEQVAKKGA
>Q399E0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MSQSTRSRQSAGTPESADGIASASRRKFLGNMAALTLAVGFSGEIALAKSVTPATAGVSF
EPNAFIRIGADGIVSVVSEYLEMGQGTFTGIATLAADELDIGLDKVRVVAAQADATRYVN
PMFAKMGWKIQATGGSTAMAGSWTVMREAAATARAMLLSAAARKWKVDPASLRIEDGVIV
HAASGRRAGFGTFAADAAREPVPSKVAVKQRTDFKLIGKRDTRRVDIPAKVNGSAIYTQD
VKLPGMLVAVIAHPPRMWGKVRHVDASKAKAIPGVVAVVQVPGDDNVQGGVAVLARNTWV
ARQGRDALKITWDDTHALALGSADISKQYRAALGKPGVVAVTRGNVVSEAPSGGKFIDAT
YEQPYLSHAPMEPLNCVVWLHADRCEIWNGEQWHTGDQVIVAKEVGLKPEQVTINQLYAG
GSFGRRANPVGDYVCEAARIARAARAQGIDAPVKLVWMREDDMRAGFYRPATLHRVRLAV
DKGGNLVSWNQDVVGQSFFAPLPSGVDPTLVEGSADIPYEIPNFKVTQHIQTLAVKTQWM
RSVGHTHAAFVGETLMDEAAHAAGKDPYAFRRALLTKMPRHRGVLDLVAQKAGWSAPLRA
GAPGTKRGRGIALQFAFGTYVAQVAEVTVLQDGRFTIDRIVCAVDCGTVVNPDVVASQVE
GGIGFGLTFLRAAITLENGRVQQGNFNDYPVLRMNGMPHVEVHVVPSQEPPSGIGEPGVP
PAAPAVANALTAATGTTFRSLPMRDTLRPA
>A0A6M4HAR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter palustris|TrEMBL
MSKFFINGDRVDFQGAPDTPLLWVLRDSYDLTGTKFGCGMALCGACTVHVNGEATRSCVT
PVSTLEGKRVTTIEGLPATAVVKAVNAAWVDKDVVQCGYCQPGQVMAATALLSKNPKPSD
ADIDAAMSGNICRCATYQRVKEAIKSASATLGPARPAAAPKKA
>A0A7X0H2N6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis sp. JAI128|TrEMBL
MVGIRDTVGKKTSRVPQVNRRSLLVGATAAGGLAIAWSLWPRDYRPNLTAAPDEHVFNAF
LKIGDDGHIGAIVPQCEMGQGVTTLLPQIMADELGADWRTIAVETAPINPLYTNTLLVDE
DSAVFTPRSGVPDFVSDVRSWARREWAVRHAVMLTANSSSVRMFEGPCRAAAAQARALLM
MAAARRWDTDWEECDTQDGFVVFGQKKLRFGEVAAVAATLEPPAEPVYRASSADPLYGKD
LTRLDLPAKIDGSANYAGDIRLPDMVFAAIRQGPVGATRLKGIDRKLGMASPGLLHVVTH
ERWVATVARNWWAANRALDRFAPVFETEGTPVSTEGIDKALKAALKGDGYRISATGDVAE
AMTGRTKIAAEYAVAPALHAPIETRTATAAPDGERLRIWVATQAPAQCRDAVAAATGLAP
ANVVLFPMMAGGSFDACLDHSVAVQAAIVALQIKRPVQLAWSRAEEIMRLPPRAPARAKL
TATLNAAGGIDALVTRIAVPATSHEVRDRLFDNAPADVAQRAAAGRPDAVAVEGAASSYA
IRHAAVDHCPADIGLPTGRWRGNADSYTAFFTECFVDEMAARAGTDALSYRMAMLGEAPL
LARCLLTATSLGGWEGGLPGTAQGLACHSMRGSHIALMATARQSERGLQVEQLVAVVDAG
RLVNPAIAHQQVEGGLIFGLAAAVGATTDYAGGVATARKLGQLGLPRLSQTPQILVEFID
SDREPGGLGEIGVPVVAPALANAMFAATGRRIRRIPLSGHPS
>A0A0H3KMX5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MTIELDTRDSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATTAPEAGAFAPNAF
LRVTPDGAVTVIAKHVELGQGAYTGIATIVAEELDADWSRVRVESAPADAKRYANLAFGT
MQGTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWNVPASELTTANGVVTHAKSGKTAA
YGTLVADASKLPVPDKVVLKQPADFKLIGHRIPRVDASAKSNGTAHFTLDTTFPGMRVAL
LQRPPRFGATVKSFDATAAKAVPGVVSVVQVPAGIAVVATGFWAAKQGRDALKVEWDETH
AEKRGSDEIMREYRQLAAKPGASARKDGDADAAIAGAARKISASYEFPYLAHAPMEPLDA
VVKLTKDSCEIWAGDQFQTVDQGNAAKVAGLKPEQVQIHTLYAGGSFGRRANAWSDYVVE
AVSIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGRLVGWRHRIVGQSI
LAGTPFEAFMVKNGIDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYA
VEAFIDEAAHAAGKDPYLFRRDLLAKEPRMRAVLGLAAQKAGWDPAKPLPKGRGRGIAVA
EAFKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIVAAQMEGGIGFGLGAAMHSA
ITLKDGRVEQRNFDGYQVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPIGPAVANAIFAA
TGKRHYVLPFDSGTNASA
>A0A2H6A425|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR33|TrEMBL
MKISFTVNTKRVTVDVPPDMPLLWVLRDVLDLKGTKFGCGAAQCGACTVHVNGAPTRSCV
LPASSVEGAEVLTVEGLSPDGSHPVQRAWQELDVPQCGYCQAGQIMAAVALLARNPNPSD
ADIDAAMNGNLCRCGTYLRIRRAIHRAAELMAAGAQPQGNGRSQRSPNGGEALRR
>A0A1P8US84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger abyssi|TrEMBL
MPKLLSRRSFLLTGAALGGTALVAAIGGVGYLSTVDVDGLEGHLDGDRAVLNAFVVIHPD
GRVVVSVPRTEMGQGIHTGLAIVVAEELDIPFDDRISVEFPTEPLPAYSNWFNVLQVRPE
EASGPAVWLGRRVLGQMGFIATGASASTMGLWHPMRVAGAAARQMLLSAAATRFDVPVRQ
LTTADGFVRHEATGQSFSYGELAREAAVLPPPSDPPLRPASEWRLIGRSQPRVDLPAKVR
GAPVFGMDVVLPDMLQASIRQAPVFGAEVLRIENEAEVRAEPGVRDVAIVGGRHVAVVAD
SWWQAEQAATLLDVTWTATGADGVSSAEMSARLQDALGSPEPYENIDDGDFDAVAAGRSG
PLIEAEYGVPFLTHACMESMNATVVIRDDGSAEAWVPSQSPMGVRTGVRTGTGWAGIEPD
KIICNITMNGGGFGRRSDQDVTAQAAYLASRHRGRPVKLIWPREEDVGRGLYRSHAAARL
RAVLGDDGLPVAYDAMVAAQSIIASVAERNLPFNPGPDGDRLSVEGLDKLYYAIPNRRMR
SQNVPSHMPIGFWRSNGFSFNTFFTESFVDECALAASADPLAYRRALLRESPRHLAVLDR
VAELSGWGTPMTPGRGRGIAIEECYRSVVAQVVEVTVAEDGELTVDRVFCALDVGLVFNP
DAVVAQMEGGIIFGVTAALMGRITLDGGSVMESNFHDYPMQRMANAPAVEVSIVDSGLPP
GGVGEPGVVPVAGAIGNAIFDATGRRLRSLPFANTESIGEQRIRTVLRPGST
>A0A7W6G5F4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MITITVNGQERHVEAEEDTPLLWALREDLGLTGTKFGCGAGLCGACTVHVEGEAMRSCQI
PVNMAQGRSITTIEGLTPAQGLHAVQAAWVAAQVPQCGYCQPGMIMAVAGLLKSNPRPDA
AAIRAGVTNLCRCGTYPRIVAAIAQLSLG
>A0A840GYJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ERR14|TrEMBL
MPTLTINGRSLSVDAANDTPLLWAIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
MLSDVAGKKITTIEGLSAKGDHPLQKAWVAEQVPQCGYCQSGQIMQAASLLSKNPNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAASEMRTASATSTERRPT
>A0A7W7Z6L0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodopseudomonas rhenobacensis|TrEMBL
MTAYRLNINGQSHAIDVDPGTPLLWAIRDGAKLTGTKYGCGVAQCGACTVYLDNQPVRSC
SLPVSAVGDSQITTIEGVGGREAAAVQAEWVKLDVPQCGYCQSGQIMSAAALLARNPKPS
DRDIDLAMAGNICRCATYVRIRAAIHGAAKTLEG
>G8TM87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Niastella koreensis (strain DSM 17620 / KACC 11465 / NBRC 106392 / GR20-10)|TrEMBL
MKQSTTNISRRHFLKITSLAGGGVLFGFEMLANVTAETVADAPLFSPNAYLSIDPQGIVT
LLAPNPEIGQGVKTSIPMLLAEELDVDWNKVVVTQAVFDKEKYGNQSAGGSGAIRGRYEP
IRKAGAVARQMLVAAAAQTWNVPEQECSTENGFVLHKASGKKLSYGELASKSATMPVPDN
IKLKDPKDFKIIGKRINNVDNKGILTGKPLFGIDTRREGMLFCMVSRPPAFGKKLKSFDD
TETRKIPGVKNVVRTDTVVAVLATNTWAAKKGRDALKVEWEDAGKLESTMEHVAAFKTLI
QQKSDKPDRNDGNVEQALSSAKKVIESVYEVPVLSHAPMEPINYFADVKDGKADLYGPTQ
VPGNAIRDVAKALGIAEANITLGMPRQGGGFGRKLRADNVVEAAQISAAAKAPVQMLWTR
EDDMQGDFYRPNGMYRYQAAINANNELDGWYLSAVALNAGRAAASENFPAGALANYRCDS
HGVQSNIQTGPWRAPTHNAIGFAEQSFLDEIAHELKKDPVAFRLELLEKAKTSPVGKVSY
DIEKFKSVINLVSKMSNWGKNTPGRFKGFAAYYSFNTYVAEVAEVSVVNGKPKVHKVWAA
VNCGQVVNLSGAENQVQGAIVDGLGHAWYSEVTFDKGAVQQKNFNAYKMMRMADAPPDVE
VQFVATNEAPTGLGEPALPPIAAVVCNAIFAATGKRIRKLPFGNALAQKA
>A0A2Z4LXS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda aurantiaca|TrEMBL
MGKKEKSEKKISRRKFFVLGSVGTIGVLAIGTYVFRGSIRRVIANQVNSAEPPYMGNTDT
PTIWFEILPDNSVMLYSPKVEMGQGVFTGLAQIAAEELEIPVSQIKVTHAPSISGNMDEF
ATGGSTSISSLWQPVRELAATMREMIKIEAAKKLEANIIDLTLANGIISNGNQSISYAET
VKDKKNWEIPDTPTLKDVKSYKLVGKPIPRVDLHDKVFGTPIFGMDAKMPDMLYGAVVRP
SAIDATLVGVHIVEAEKMPGVVKVVKENDFVGVVANSLLEAENAKKAIETNWKSEKFWQT
SDIEAMVEVGKGKPFVIQKEGNVEKLFEDDKGIVISEFKSPIGAHAQLEPNGALAHVEAD
KVTVIISTQVVKITRDEIAERLGMDKEKVNIVPTFLGGGFGRRLHTPNGMQAAVLSKAVG
KPVKCFFTRKEEFQNDTFRPPTHHVLKAKLSENGMIEGIEHNVSSGDVAFGSPMLPSFAE
PILGADLGAWRGGMIQYGKIPNFQAISWRVKLPFATSWWRSLGLLANTFAIESFMDELSI
KAKKDPVQFRLDQIQDDKRGIRLKKVIRAVAKKAGYVDEVINGRAMGFAASTDANTPCAQ
VVEVSITNDKIKVHKVTCAMDPGIIINPDQVRAQCEGAIIMGMSASIFEKMEVVDGELTP
TIYGPYQMALMKDAPKEIDVVLLQNDDKPDAVGEPPLGPIGAAVANAVFRLTGKRIRTMP
LQFALNNHKSA
>A0A0A1I3L8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. SHC52|TrEMBL
MSRLPNDFVLSNLSRRGFLKGASATGALVLAASWGLPDAFAEEKKFGAEGMPHGAVDDPK
VYVSIAADGSVTVICNRSEMGQGVRTSLSMVVADELDADWALVKVQQAPADEARFGNQDT
DGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWNVPVGECHAQLHNVVHQPSGRKLGYGAL
AAAASALPVPARDTLRLKQPAEFRYIGKEASRAIDGADVVNGRAVFGADVHFDGMLYAVV
ARPPVYGGKVKTVDDSAALKVPGVVKVVQIEGRPLPSEFQPLGGVAVVAKNTWAAIKGRD
ALKIEWDDGPNAGYDSVAYRKELEAAALKPGKVLRSTGDLDDALAKADSTLEASYYLPHL
SQSPMEPMVAVARFKDGQCEAWAPSQAPQVTRERVAERLGIPFDKVTINITLLGGGFGRK
SKPDFVVEAAVLAKEFAGQAVRVQWTREDDIHHSYFHTVSAEYLKAGLNRDGMPSGWLHR
TVAPSITALFAPNMVHEAPFEVGMGVTNMAYAIPNLRLENPEAVAHTRVGWYRSVSNIPH
GFAIQSFIDELAHKAGQDPLKYHLKLLGPDRKIDPRTLNEEWNYGESPERYPIDTARIRT
VLETAAKAAGWGQKLPKGRGLGLAVHYSFVTYVAAAIEVEVKEDGTVIVHKANIAVDCGP
QINPERIRSQFEGACVMGLGNAMVGEISFKDGKVQQDNFHMYEVARMSLAPREVAVHLVT
PPGEVPLGGVGEPGVPPIAPALCNAIFAATGQRIRNLPVRYQLQGWQQAKA
>D4YZT0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)|TrEMBL
MGRAPRKQGQQTERGLNRRTLLVGGGATAGLLLAWGGWPRAYRANLNTAPGETAFNAFLK
IDRSGQIIVIVPQTEMGQGVSTLLPQILADELGADWRTIGVQSAPIGPLYANNLLARQWL
ANDWSRLAGEAGEWAIDQYATRSALMLTGAGTSIPMFHQPYREAGAAARVLLCKAAAARW
DVAWESCDIRDGIVSDGGKRTLKLGEVAEDAATFDLPDILPFRQADVDRLAGQELPRLDT
PSKIDGSHNFAADIRLPDMAFASIRQGPIGDAVLKSVNEGAAKSVTGFLKLVRRERWVAA
IASNWWAANKALDLADPVFALSGTPVGSAGIEAALEQAFADSSGERLYARGDPQSLSEDA
TVLASEYRVRPGLHLAMEPTCATARIGEDGAEVWMATQAPGLARAAIARALDLPAEAVTL
YPLHAGGGHGRRMDFEAGVQAALLSREMGRPVQLLWSRLEDVIQDRPSAPAHARMAGKLG
RNGAVEGWSAKVAAPCALTQTWARIAHGKLPHEASADASGTSTRLAVAGMDLPYSVPNWA
VDHFPADVGLPLGFARGNANLHGAFFTESFMDELAHQAQMEAMSFRIQMLGGNPRLAHCL
TTVGAMGGWQGGIEGSGQGLAAHVMNGAFIAVMVEAGVDEGKLQVSRIVAAVDGGEQVNP
DIARQQVESGLIHGLAFAMGASVPYAKGMPTRAILGRMGLPRLGDVGEVTVELIRSTAPP
AGLTDLGAPVVAPAVANALFTTTGRRFRSLPLLMEG
>A0A8F8UCV9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea coxensis DSM 45129|TrEMBL
MPEHTFRVNGEQVTVDVADDVRLLWVLRDVLGITGPKYGCGINVCKACTSHLNGKAVNPC
AIPVKDLRPSDEVTTIEGLPATVGQDLHPMQRAWLEHDVAQCGYCQPGQIMAAVALVNRV
AAEGRAITDADLDGIRNICRCGTYVRIRQAIRKGAEHI
>A0A379KXN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MNTPVDTPAELLGLQRGETVNLSRRRFLAGTAVGALVLGFGLPVGVPRVQAAAVATAERG
TQVPAFLEIRPDGTVRLLSPFMEGGQGPFTAMAQIVGEELDVDPAHFVVESAPPGEAYVV
MENGMRITGGSMSVRMSYPTMRRLGALARAMLLQAGAEKLGVPVAELSSTPGNVVHTTSG
RSVPYGELAGRAMDLPVPDPASVKLRDPGQFRWIGKPVRRLDAYDKSTGKAQYCIDIKVD
GMLHAAVQHAPRLGMTVGSLRNEGQVKAMNGVHSVHQLPGAVAVVAERWWHAKRAVEALQ
VDWQEPAADSTLRAMPADFSSDGWREHLATVDGPARDEENEGDVAGALANAKTRVEASYH
NQYLNHAQLEPPSALARFNADGTLDVWLPNQAPDMFRDDIAQRTGLQTSQINLHSPLLGG
FFGRHFLYESANPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAVVKFRAGLDADGL
PVAIEAVSATEGPTEALAGKQGDKVDPTALEGLSGKAYAIANKRIAQVYVKGPAMLGYWR
SVGNSLNDFFYESFLDELADKGGKDPFELRLHLLRDNPRLTTLLNAVADLSGGWKRGPFT
AEDGSKRARGVAMASPFGSHAAVIAEVSMENGQVKVHDIWQAIDPGSIVNPAIIEHQVNG
AVALGLSQTLVEEAVYVDGKPRARNYDLYPILPPSRIARVHVRIVESGAKMGGIGEPPLP
AVAPAVANAVAQLTGQRVRSLPMSRHTFS
>A0A5B8RK82|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured organism|TrEMBL
MESLWPGSVTDGLDPLAVEGAVALPYAIPRAAVGYAMRDVGVPVGMWRSVGHSYNAFAVE
CFVDELAGRAGIDPVDYRLRLLGDAPRLAAVVELAAARAGWGSPRAGRAQGIAAHACFGS
YVAQVAEVSRDDDGGVRVHRVVCAVDCGIAVHPDTVAAQMEGAIAFALTATLYSRITRGT
NGTVESNFHDFPLLRFSRMPRVDTHIVPSREAPGGVGEPGVPPLAPAVANAVSALTGQRL
RELPLRLNSDA
>A0A839ZYD2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phenylobacterium haematophilum|TrEMBL
MAFKLNVNGKVLSADVDGDTPLLWVLRDTLGILGPKYGCGVAQCGACTVHIDGAPMRSCA
IPVEGLGQSKIVTIEGVGASAVGKKVQQAWSELDVAQCGYCQAGQIMSATALLAEKPKPT
DADIDEAMAGNLCRCATYTRIRAAIKLASGQKTEA
>A0A654B4Z2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas titanicae|TrEMBL
MTAFTINGRVVDVDAAQDTPLLWVIREHLQLTGTKFGCGIAQCGACTVHIDGAPTRSCVT
WLEDVAGREVTTIEGLSPDASHPLQKAWIDEQVPQCGYCQSGQLMQAAALLESNPNPTRE
QIIEHMDGNICRCGTYVRVISAIQLAAREA
>A0A840S7G6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Inhella inkyongensis|TrEMBL
MIIDRLPNLAPLGRRHFLVTSVAGLTGLALSPWQALAQPEAKAKPGQAPTEQPPAFVHIA
PDGQTTILCNRMDMGQGIETALAMICAEELEVEWSAVRTGFGNQKPAYVDPAMGMHLTGG
SNSIKNSYTQYRELGARCRAMLLAAAAQAWGEPVQDLRSERGRVIGKQRSAGYGELFEAA
MRLPVPEAVTLKPAAQFSLIGKPMGLKVARAKSDGTQVYGMDIRLPGMKSAVIERPPVFN
GKVASFDASAALAIPGVRAVFKVALDRGGEGLAVVADGYWPAQQARKALKIQWQLDGLGR
ADTDQLRAQYLALANTEGALVPDPRFRKELPPLAKSPKRIVADFVFPYLNHAQMEPLACT
VDLQPDACTLHYASQMPGVDAGAVAQQTGLPFDKVNIQVQMAGGGFGRRATPTAEFVREA
VAVAQGLAAAGQRAPVKVIWSREDDMKAGYYRPFTVHRAEIGFDAQGQVQGWNHRIVSQS
IVTGSPFEPFMVKDGVDATTPEGMGEPYQVPMRLSVHHPKVNVPVLWWRSVGSTHTAYVM
ETLIDEIAQATRQDPVAYRRKMIHPEAKRTLAALNLAVERSGYETRKLAPGQAWGVAVHA
SFESVVAYVVLATLEGKGKARRPRLLEVHAGVHCNLCVNPRTVEAQVQGAALMALGTTLP
NHRITLKDGRVEQGNFDAYAMPRMADAPQRVAVHIVPSQDAPTGMGEPGLPPLAPALANA
VARLTGRRQRELPFAPL
>A0A840SD36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Inhella inkyongensis|TrEMBL
MPSLNLNGQVQTLDLEPEMPLLWVLRDELGLSATKFGCGVGACGACTVQIDGQAARSCVT
PLAAVGERAVRTLEGLLDDPLMQGLQAAWLTEQVPQCGYCQVGLLMAAHALLSKSARPSE
REMEAALSNLCRCGTYPRVRRAMAQVIARVPA
>A0A0C4YGH9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MSTLQSAGRRAWLKGMGALAGLTLTVGLDGIVLAADEPKKYGRDGMPGGAVDSPLVFLSI
AEDGKVSIVCHRSEMGQGVRTSLPMVVADELEADWARVLVVQAPGDEIRYGNQNTDGSRS
VRHFFEPMRRVGASARMMLEAAAAARWNVPASEVQARNHAVVHVPSGKSLGFGALAKDAA
RLPVPAAASLKLKDPAQFRYIGKDSTRSIDGHDIATGRAQYGIDVRLDGMLYAVIARPPV
FGGKLAGVDSTLAMKVPGVIKVVELAGSPAPALFHPLGGVAVIATNTWSAIKGREALKLR
WDDGPNASYESGAFRAAMEKAASQPGKVVRNQGDTMAALSGPGKRIVAQYYLPHIAHATM
EPPVATARIADGKCEVWTSVQAPQATRETVAGHLGLKPEDVTVHVTLLGGGFGRKSKPDF
AAEAALLSKAMGGKPVKVTWTRDDDLHHDYFHTVSVEHMEAMLGTDGKTQAWLHRTAAST
ITSTFVAGAKNEAAFELGMSAVNMPFDIPNVRVENPEVEAHTRIGWFRSVSNIPHAFAVQ
SFAAELATAAGRDHRDYLLALLGPDRRIDPTQLSDTWNYGESPQQYPLDIGRLRGVIELA
TREAGWGKTLPKGRGLGLAVCYSFVTYVAAVVEVVVADDGSISVPRIDMAVDCGAQVNPD
RIRSQVEGACIMGISLATTGEITFKDGRAQQDNFHQYEVMRAPSAPRQIHVHLVPGKFDA
PLGGVGEPAVPTIAPALCNAIFAATGKRIRALPIREQLKKA
>A0A0C4YKU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MTPLQRNDSNESSDVKSPQRRRLLKSAVALLAIPAAGSLAIPVVYSLSEKHSGTPAAEVE
VSDWIWIEPSGHTIIGVSQCEFGQGIYTGLPQVLADEMDADWENISVKFVTARDAYRNDA
GDEPLQQYTGASMSMTYFFERMRLAGAQARDVLLRAGAQRLGVRSSQCTTRTGRVIHPAT
GRSIGYGEVVADAIKLRINPHPRMKVPSEHSLIGKNLRRVDTPPKVDGSAVFGMDVEVPG
MLIGAVRMAPSVTGSIVRIRNEAEIRKREGVKAIVVTSLWPVPTRNTVIVVANSYWTAKQ
ALDALDIEFDAGAARNTSSDLIRKQFVEGLDSKDAPVARRIGNPEEILNGPGKRVVVSAD
YHTPYVAHATMEPVVATVDVREGEIEAWGPFQGQDFLRGELGKAFGLPPDKVTVHTVYLG
GSFGRKYLPDFALHAAAASKAVGKPVKVIRSREDDTRHSYYRPGAAGRFRAVLGDGGMPL
ALHARISGQSLYGVIKQDKMAAVGGWDETMVESIYDLIYRVPHLLVDAVDVKQPIPLSFL
RSVGSTSSVFFLESFVSELAHAAGADDYQYRRKLLAEQPLALRVLDATAKAAQWEREAGP
GVFRGMAFNVYTGRGEGFQTYVALVIELEVVQGRVKLKRAVCGVDAGRAVNPGLIKANME
GGIGFALTNTFKSELTFDKGAIRQSSFHDYPLLQLAEMPNVEVTILESDRPPQGCGEVVL
GPTAPAVASAMFHATGTRFRSMPLPQSV
>A0A0C4YAF4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MLPLNINGKTVSVQSDPDTPLLWVLRCELGLTGTKYGCGIGVCRACTVQLNGAPQVACMS
PVSTLANIRIVTIEGLRGAQAQALRAAWLDLDVVQCGYCQSAQLMTASALLRSIPKPSDA
DIDRAMAHIVCRCGTYPRIRAAIHQAAGQPRT
>A0A1U7CZX8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MASAGTIARRGFLFGSAAIAGGVALGVWYLHAPAPNPLRPGAGETALSPFVLIDGSGVTL
IAPRAEMGQGTQTTWAALLAEEMDLAWEDVRVIHGPPGVAYYNAAMMAENAPGPPYGKSA
FQQAVGEAMGTLGKPLRMQVTGGSTAMKDGFERMRAAGAAAREMLKGAAAARLGLDVAQL
RTETGAVIAPDGTRLPYTELAAGAAAITPREITLRPPSEWRLLGRALPRLDTVAKSTGTA
TFGIDVRPEGLRFAALRMSPRRGAMLHYDAMAARGMPGVEKIVDLGDGIAVIASNTWLAQ
QAVQAIPVDWGPAPYPADTAAILARIEAAFDTAPDSTLLDRGDPDRLPEGATEITAEYSV
PFLAHATMEPLNATAHVTAEGLELWCGNQLPTYTRSACAAEAGLPEDRVTVHTTLMGGGF
GRRGELDFSVLATRVAKALPGIPVMTTWSREEDMTHDFYRPAAIARMRGAVRDGTALLFD
AAVAGPSTARQALDRWMGFAPPGPDKVHVEGLWNQPYAIPNARARGHVAPDLAVPVGFWR
SVGNSYNGFFHESFMDELAHAAAADPLAFRLSLARKAWTPAASVLEAVREMSGWPDKPAG
TGRGVAMCYSFGTPVACVIEVAEDGGDIRLTRAWMAADVGVALDPGILDQQLVGGLVYGL
SAAMMGEITFADGMVEQQNFPDYDALRLSQMPEVETRILQGQDRISGIGEPGTPPAAPAL
ANALFDLTGVRHRDLPLNRTVSFAI
>A0A2S2DYR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aquirufa nivalisilvae|TrEMBL
MIKKFTLRINKKPQTVEADENMPLLWVLRDVLDLKGTKYGCGVGSCGACTVHLNGIAVRS
CQLPISSLANQNITTIEGLAEKADHPVQKAWLDVDVAQCGYCQSGQIMSAAALLKSNPNP
SEEDIDNFMSGNICRCGTYTRIKKAIQQAAAKK
>U2EIX7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinisphaera shabanensis E1L3A|TrEMBL
MGGVMGTEVHIEIDLRAQTLTLLDQQDHEIKQYDVSTATKGGGEFEGSNQTPRGKHRIRA
KIGADSPPGTVFKERRPTGEVYSVELAESAPREDWILSRILWLCGEEIGRNRLGAMDSMR
RNIYIHGAADTAVMGKPGSTGCIRMSNSDVIDLFDRIDVGTKVLIHE
>Q8ECT3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella oneidensis (strain MR-1)|TrEMBL
MAIPSSAAKDKSLTTPSLNLTINGRSFTLNADPNMPILWALRDILGLTGTKYGCGAGLCG
ACTVHVDGQPVRACLTSVSQAQGKQLTTIEGLDNQKLKNAWAEHNVPQCGYCQAGQLMSA
AALVTQHPKPSAEQIDAAMSGNLCRCGTYPRIKAALQSYAKQEG
>A0A6A7SK01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|wastewater metagenome|TrEMBL
MSTFTVNGKTHRFDGDPQTPLLWYLRDVSRLTGTKYGCGMSLCGTCTVHLDGEPVRSCVT
PVSQAEGKAVTTIEAMSEDAVGRRVQQAWLDLGVAQCGYCQAGQIMSATALLRDNPAPDD
EQINQAMSGNICRCGTYARIRQAIHRAAATQEDEA
>A0A7W4Z4F3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Litorivivens lipolytica|TrEMBL
MKKTLLRRDFLRATAIAGGGMLVACKWDSDSSSRPTPASSARRNDETPAADPNAERWTPN
AFIRISADNFVTVIVGAAEIGQGTMTAVPMIVAEELDADWERVSWEQSEASAITYGNPFW
QSEGGLGDLDQAGLQITAASTTVRGYYDSQRRAGAAVRQMLLEAASDQLNVPVESLTTRN
SFVIHTASRSRLSYGSLAAAAAEKLPPLSPPLKDPSEFRLIGQRKQRLDAAEKSDGSLDY
GFDFKIPNMVTVMVIRAPRFGAQLIGHKVGDAVDVDGFRGVHPIPSGLAVVADDYWSAEQ
ARKLITTEWIGGEELSTADLKDQFDTRNSLPGVPVRNDALRLPGLPSGDITEDYHFPYLA
HAPMEPLNVTIDYRGSECEIWCGSQWPDMDQLVAATVLGLPPAAVKFNNLLSGGGFGRRA
CLGFDYIQEAAHVARVVGQPLKVVWTREDDIRGGYYRPYTACRLSASLDGAGGIASWSHR
VASQTLLVNPIVETALGQVTEEVQTSQGAKEMPYAIPDVYVDTHAISNGVPTLWVRSVAN
ATNVYAVETFFDHLAKQAGRHPLSLRRELLQEKPRHLAVLNAVAEMANWTPETNDSLFRG
VAVFASYESVIAQLIEADVEKQGEGKHKVSIRKVYSAVDCGTAVNPDLVEAQIESGIVFA
LSSILFGEIELENGEVKQSNFHDYPVLRMYQSPAMETRVLPSDHSPGGVGELGVPCVGPA
LANAIYAATETLYTSLPLNRHASLVFE
>A0A3B0T8G7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MTAPDSPKAINRRSFLKKSGWIAAGVTVTVLASYRVVRSALPALPAFNRPELEDALAWVQ
ALPGGRIRFFCPRMEMGQGATLGLAQVVAEELNIDQPDIDCILPDTDQSAPFQMTVGSQS
IANFFEPVSYGAARLREALRKLAAEKAGLDPDQVRDGRGGFVLPDGAAIGYGEIVPFEPV
IITGEDAFKPDEALARHALRRKGKPRAIGASWKHPELEAIVTGQAVYSRDVSIPKMAYGQ
VVAPPAFGAQLQSADGRAAEALPGVVGVVIDKGENFVGVVTDDPLALSQAIAAIDTKWEM
PQDLEQDDIEARLDVAAFRADDDFDHTIRSSGDLDTGRQTARFLATARYDTPFAAHAAME
PRSGLAHVQEDKVEVWSASQDPFFVQRRVAKITGHAIDDVVVRTHRLGGGFGGRVLCQAA
EEAARLSAAVRRPVRVQWDRETEFSNNHVQPPFFHLIDAGVTAEGEISHWDHDFTSSSIL
SGILPQTLGAAVDMARPDGGTVRGVVPQYRMANRRIRYTGIRTPVFIGAWRGLGAAPNAF
AIESMMDELAAEASIDPLDFRLKNLPPAGDRLAAVLREVAQIADWGRQTPPGTALGLASA
VYDDKTAVAIVAEVQVDHTAQTIAVSQVWCAQDCGLVINPHQVENQIMGNIVWGCSMALK
ERITISAGRVGEDNFDTYEILRHQDAPDVTVSLVEPDNTPPVGVGESALAPVAPAIANAV
FAATGKRVRRLPMSYEDVVPAARS
>A0A081RFH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium chlorophenolicum|TrEMBL
MGRAPRKQGQQTERGLNRRALLVGGGATAGLLLAWAVWPRAYRPNLNTAPGETAFNTFLK
IDRAGQIIVIVPQTEMGQGVSTLLPQILADELGADWRTIGVQSAPIGPLYANILLARQWL
ANDWSRLAGEAGEWAIDQYATRSALMLTGAGTSIPMFHQPYREAGAAARVLLCKAAAARW
DVAWESCDIQNGIISDGGKRTLKLGEVAEDAATFDLPDILPFRQAEVDRLAGQELPRLDT
PSKIDGSHVFAADVRLPDMVFASIRQGPIGDAVLKSVNEGAAKSVAGFLKLVRRERWVAA
VASNWWAANKALDLADPLFELAGKPVDSAGMEAALERAFSASGERLYAQGDLKPLFKDAT
IIASEYRVRPGLHLAPEPMCATARIGDDGAEVWMATQAPGLARAAIAKALDLSPGAVTLY
PLHAGGGYGRRMDHDAGVQAALLSREMKRPVQLLWSRLEDVVQDRPGAPAHARMAARLGR
NGAIEGWLAKVAAPCAMTQTWARIADGKPPHEAAAASADISTRLAVAGMELPYAVPNWAV
DHFPADIGLPLGFTRGNAHLHGAFFTESFMDELAHQAQMEAMSFRIQMLGGNPRLAHCLT
TVGALGGWQGGIEGSGQGLAAHAMNGAYIAVMVEAAIVEGKLQVGRIVAAVDGGEQVNPD
IARQQIESGLIHGLAMAMGASVPYAKAMPTRAILGRMGLPRLADIGEVTVELIRSTAPPA
GLTDLGVPVVAPAVANALFTTTGRRFRSLPLLMEG
>A0A4U8Z2Y2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylocella tundrae|TrEMBL
MAYTIKVNGVERTADVDGDTPLLWVLRDVFGMTGTKFGCGASLCGACTVHQDGNAIRSCI
TSIDSIGESSIMTIEAIGDTPSGAKIQKAWLDLEAPQCGYCQSGQIMSAAALLAGNAHPS
DSDIDEAMSGNICRCGTYSRIREAIKLAAGENAVKQGG
>A0A7X0EC81|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospirillum iridis|TrEMBL
MSDGIANLSRRAVLMGLGAGTFILAGGLAPRARAEEPSKKYGGDAMPGGVKDDPRLFVAV
AADGAVTILCHRAEMGQGVRTSWAMVIADEMDADWAKVTVDQALGDEGRYGNQNTDGSRS
MRHHFQALRRIGAAARQMLVQAAATQWGVPVAEVTAEHHTLMHGPSGRRLGYGEVAAAAA
ALPVPARETLVFKDPARFRYIGRGDVGLVDGFDITTGRATYGIDVRRDGMVYAVVARPPV
YGGRVVHYDVDEALKVPGVLKVVVLNAAPPPSGFLPKGGLAVVAENTWAALQGREKLKIT
WEDGPNASYDSAAYRAELEAAARAPGQVVRDTGDVNGALKTAAKRVTAEYYIPHLAQAPM
EPPAAVAQVTGNKCEIWGSTQAPQATRETVAKVLSMPTENVTVHQTLVGGGFGRKSKPDY
IAEAALLSRAMDGRPVKLTFTRQDDLHHGFLHTVSVERLEGGLDAKGKPVAWLHRTVAPA
ISATFSAGVTHEGASELGMGAVNTPWVVPNLRVENPEAVSHTRIGWFRSVSNIPHAFAVQ
SFVAELAAAAGRDPKDFLLDLIGPPRQINPADMSDSWNYNEDPVAYAYDTGRLRGVVERA
AKEAGWGKPLPKGQGRGIAAHRSFASYAAAVVQVTVGAQGKLTIPRVDIAFDCGPVINPD
RVRAQLEGAVTQGISLATLGEISFKAGQVQQNNFDSYEVTRIDAAPRDIRIHLMPAATYD
APLGGVGEPGVPPIAPALLNAVFAATGKRIRSLPIRDQLRT
>A0A839U7J8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MITFKLNGQERTFDGDPETPLLWVIRDFEKLSGTKYGCGIAQCGACTVHMDGTTRRSCIT
PISTVEGSDIITIEGIEGKEAEAIHKAWVAIDVPQCGYCQSGQIMSAVALLQTTPKPTDD
DIDGAMAGNICRCATYHRIRQAIHNAADTMEG
>A0A7W6ST29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MNKHVSPKMNRRAFVIGTAAVGTGLAIGLEIPFGGPAVVRAADGSPEIGAWVVVRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELECDWSKVTTEYPTPGQSVARKRVWGDFSTGGSRGI
RSSQDYVRKGGATARVMLIEAAANEWKVPASECTVARGVITHKASGRTTTYGKVAEAAAK
LTPPADVKLKDPKDWTIVGKGLLRLDTADKTTGAMTYGIDVKLPGMLNAAIKDCPVFGGK
LKSYDEAKITGMKGVKKVVKVGDTAVAVVADTWWHAKTALEALPIVWDEGDNAKVSSESI
AKWLAEGLDDGQPAYVGNKNGDAKAAIAGAAKKVEAVYSYPYQNHATMEPMNATAVYTAD
KCEVWCGTQNGEAAFAAVLEASGLPAEKCDVHKVMPGGGFGRRGQTDYVRQAVMIAKQMP
GTPVKLLWSREEDMAHGRYHPITQCKMTGAFDANNNLVALHYRLSGQSILFSLRPEALQN
GMDPAAFQGVAQSGEAAFGYSVPNLLVEHAMRNPHVPPGFWRGVNVNHNAIYMECFMDEL
AQAAGQDPLEFRRKLMGNHPKHLAVLNAVAEKIGWNTPAPQGVYRGIAQVMGYGSYVAGA
AEISVTEGNKIKVHRIVASTDPGYVVNPAQVERQVAGSFVYGLSALFYGGCTVKDGKIEQ
TNFDTYNSMRINEMPKVETVMVPSGGFWGGVGEPTIGVAAPAVLNAYFAATGKRIRSVPL
RDQNITFA
>A0A132BUY4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter horizontis|TrEMBL
MSLTTSRRGFLTSAAAAGTVLFIGVNARGALAASPSAEAMLTPFVKIDETGKVFAIIKHF
EMGQGPSTGLSTIIAEEVGVTMAQIGFEFAPSDPQLYNNLFFGPFQGTGGSTAIANSWQQ
YRTAGATARQMLVEAAAEAWAVDAGTLDIVDGQVTGAGQSAPLGAFVAAAARRTVPENPP
LRDPAQWKIIGNPATRRLDSPDKVNGTAMFAMDVQLPNQMVVMIKRTPQRGGLVTSFDDS
AAQEIKGFLMAQTLPTRHGVAVYAENTWAAIQAREALEVDWDMSAAESRSSQEIRDEIMT
ALNTEPTYNVNKADRAAVKATVDGADTVLEKTFYFPLLAHAPMEPLNCTIEQTAEGDIVL
HDGAQMPTGPHMAYQQIFGLPAEKIRINTMLAGGSFGRRATPDADYQVEAALAFVMTDRA
RPVKLVWTREDDIRGGYYRPATGHKVRVGLDQSGKIVGWDHQVAGQSIAKGTPFEPMMVH
DGIDHSTVEGIADSPYSIPGMSLGLTDTQKATSVLWWRSVGHTHTAYVMETMMDLVARAA
GQDPVAFRLAHLADGTEDQARKAGVLKLAAEKANWGRAPAGHTQGIAVHKSFGSYVAEVV
EISGTPEDGIVIEKVTAAVDCGIAINPDVIKAQVEGGIGYGIGHAMRDQITLDGGAVEQS
NFPDYEPLRISDIKEIETHIVASTIAPTGIGEPGTPPSAPALANALAALSDGADLVAELP
MAEAGVYFA
>Q2L204|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella avium (strain 197N)|TrEMBL
MASSLSTASAIRLMVNGCTHDVPASADTALLHVLRNDLELNGPKYGCGLGECGACTVLID
GVAARSCVIPVKAAQGRAVTTLEGLGRRQAPGPTQQAFIECQAAQCGYCLNGMIMTVEAL
LRRNPRPTEHMLRNELHHNLCRCGTHVEIMQAALRAVQLRAETGAQSADEARR
>A0A0H2MC29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax paradoxus|TrEMBL
MSALNVNGRDHTVDADPGTPILWALRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCIT
PISAAEGKKIVTIESATDGSDPVGAAVHAAWVRHDVAQCGYCQSGQIMSATAFLKSQPQG
KQPTAAEIDAAMAGNICRCGTYARIRAAVADAAKTLA
>A0A2N9AH96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens|TrEMBL
MISLSINGHQHSIDVEPDTPLLFALRDTIGLTGTKYGCGIGQCGACTVLIDGQAIRSCQM
PVESVGAQTVTTIEAIEADPVGARVVAAWVGIEVPQCGYCQSGQVMAATGLLKETPKPSE
DAIAAAMTNLCRCGTYNAIAAAVRQAAA
>A0A508TZM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MDWTNQGTAMANLKINGKTITVDVEDDTPLLWAIRENVGLTGTKYGCGIAQCGACTVHMD
GVAMRSCGVTVGEAAGKDITTIEGLAVGGALHKVQQAWIANDVPQCGYCQSGMIMAVAAL
LKDNPKPTDDDINDAITNICRCGTFQQVREAIHAAANA
>A0A1S7SHX7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Agrobacterium sp. NCPPB 925|TrEMBL
MRTGTNNGTSAMSEHREAPKHQYFAQEDMLAVVSDTAAGDEAELFVAIGKDGQVVAFNGH
VDLGTGIRTSLAQIVAEELFVPFEQVRMVLGTTTVAPDQGATIASETIQITAIPLRQACA
TALRFLLQKAAIRTGVAVDHLIIEDGVIHSAGGENWSLSFADLVAGEHVRLSVDPAAPLK
PASLYRLVGISRPRVDIPAKATGRWTYVHDVRVPGMLHGRVVRPPYAGFDHGAHVGTSLM
SIDESSVSHIEGLVAVIAVGDFVGVVATREENAVEAARCLHVEWRTPPEQPDLNFPEQAL
RANPSKPRKLADRGNVDLALAGSAQPMNRTYVWPYQMHASIGPSCAVADYRDDGLTVWSG
TQNPFPMRRDLALLLDMPEDLIVVERMEAAGCYGRNCADDVTADAALLSRAVNAPVRVQL
TREQEHAWEPKGAAQIMDVRGGLDLEGGPAAYDFETRYPSNLAPTLSLVLTGKISPMAAV
VQMGDRTAIPPYDYGNLRVTVHDMPPIARASWFRGVSAMPNTFAHECYVDELAAAAGVDP
IEYRLRYLHDPRAVDLVNAVAERARWVPHTKWGTLGGEGDLLYGRGFAYAVYIHGPFPGK
AAAWAAWVADVAVNVKTGEIAVTKVTCGQDSGMMINPDGVRHQIHGNVIQSTSRVLKEKV
EFSSTAVTSKEWGGYPLITFPEVPDIDVLMVPRPDEPPLGVGESASVPSASAIANAVYDA
TGIRFRELPLTPEMVLAALNGGSPPPPATRKKRNWWNIGLSVAGAVAAVSGVVSMASPWR
PAIAPIPRPDANVYSAATIERGRLAAAAGACNVCHVGNDGTPFAGGRRFDTPFGQVYATN
ITPDVEVGIGAWSYSAFERAMRQGVSRDGHHLYPAHPYTSFAGAEDADIQALYAYMMTQT
PVALKAPETRLNFPFSVRALMAGWNMLFLKNGTFAYDQSRDATWNRGAYLVETLGHCSAC
HTDRNVLGAEKNGAARLSGGFADGWDAPALNSFAKGPVGWTAEAFYDYLRTGHSKDHGSA
SGPMSHVVEVMQPLPDDDIRAMATYLASLNDAAPAVDAEAKRTAAIAAGEASETNAATLA
PKGARMFSGACASCHEGNDILSSLALNTNLHSDRPDNVLQAILGGLDAPAIIAATTGRDA
PEIMSMPAFDGTLDASQLEDLTAYLRARFAPDKPAWEDIQAAITRVRSTANHH
>A0A841J3Z6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium subterraneum|TrEMBL
MTKFTVNDRPIQYRMDPETPLLWALRDASNLTGTKYGCGTGDCGACIVDIDGQSVRSCRI
SIAACEGRFVTTIEALSTDRSHPVQQAWVAENLPQCGYCQSGLIMAAAVLLKRNPHPTDE
QIDGALTNLCRCGTQPRWRAAIRRAEKIQAGEEKVAAAPPPGITPEDAARAVPALRAVAT
KPAADGVAPLATRPPAEQ
>A0A7W6MAC7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter noctilucicola|TrEMBL
MKLTVNGTEHEVDVEDDMPLLWVLRDELGITGPKYGCGIAQCGACTVHMDGVAVRSCQVA
AADVDGDITTIEGLGTPKAMHAVQEAWVEHQVAQCGYCQSGQIMQAASFLDLNAEPTDDQ
IDAAMSGNLCRCGSYPRIRDAVKTAARRLQGV
>A0A099L8F9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassotalea sp. ND16A|TrEMBL
MNKHILDAMSAYYDANPIESSIVSQPATIAFDNVSRRNFLKVAGIASSGLVMGVSLPSFA
GTANKGSAAAEFNPNAFIHLSENGDTLIYCGRCEMGQGISTALPAAVADEMEADWSKVSI
EQADGNEAKFGSQATGGSASIRKMFEPMRKAGAAAKEMLILAAAKVWQVNASDCYAENHF
VINKQNQQKLSYGELATLAANIEVPIDPKLKSKSQYRYIGKALDRHDQGKVVVGKRVYGV
DTKLPGMKYAAIVHCPVLGGKLKSVDNSQALKMSGVIDVVEISPIKHPFSSIGAVAVVAD
NSWTAQQAVKQLKIEWDLGANAVYNTQEYKAQLVKNVETEAQLVTARGDIKKAFSNAATT
LSATYTGGHLSHAPMEPNASVVWVQKDSCEVWASTQSPADIQKVLAQYLKRKPEDINVHV
MMAGGAFGRKFKCDYVHEAAVISEKINAPVQLTWTREEDMRTGFYHSINAQHIQASMDEQ
GKVTGWLHRAAFPSINTLFDASVSRPSKNNFSEIDEHPFGIKNYRSESGESPAHTRIGWY
RAVYAIFYGFAMGTFADELADKAQQDTVKFLHSIYDANTNAEQQQNTKRSKAVLDLAAKG
AGWGKKLPKGEGIGIAVHYSFRSYVAMAVHVKVDGDNIKVLNVDCAIDCGQVLNTDGATA
QMEGAVVMGMSLALATEITFRDGAVVNSNFHDYPVMRLKDMPKVTVHIVDSDEKPTGLGE
PGVSPFAPALSNAVYAASGKRYRDLPFKPLKV
>A0A2U3QJZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfobium mesophilum|TrEMBL
MISLEINGKQHSVDVEPDVPLLWVIREHLRLTGTKFGCGIGMCGSCTVHVDGKAERSCQI
PVGQAQGKKITTIEEVGSTPAGAAVQKAWVIEDVPQCGYCQSGQIMAAAALLSRTPKPTD
AEIDDNLSGNLCRCGTYQRIRNAVQTASRTMRKGGKP
>A0A5P9PML2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. YIM 10|TrEMBL
MPRYAFTLNGQPVSVEAPADHPLLWTLRDQLGLTGPKMGCNLDVCKACTCLIDGAPFTTC
VTAVADVAGREVTTIEGLADGDTLHPVQEAWIEQDVAQCGFCQPGQIMAAIGLLNRTAEP
SDAEIDEIENVCRCGTYFRIREAIKSAARKKASR
>A0A7W8B880|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces eurocidicus|TrEMBL
MTEQPNLEARTEHPARPAQGTWQGRADPASPPHRTRRRFLTYLVAAPTLAVGTGLALDGV
PPAAAEAVVPTLPAAADLVDLGDVLILAGAPTAHLLVLTVGEDGTVTFRLPREEVGQGIT
TAVAMLVAEELDVPLAKVRVQLDDARPELLFNQFTGSSNSIRSLYDPVRRTAAAARARLV
HAAAGRWGLEPGTLRTEDGSVVAPDGRTAPYGSLTAAAASRHLAALTATPKPESAHRLVG
TPTSRIDARAMVTGRQRYTLDLDVPGAKPCMVRRPPTLGGTVRSVNNERAVRAMPGVLDT
VVVPTGVAVVAETFGQALDAKNALDVTWGPGTVDGLSDDGIRARLRAATSLPPITLPLAE
HLDAEFDFAFVSHAPMETNSAVADVRPDRAEIWSALKTPIVAQQTLAKELGLPVDKVTVH
VVQGGGSFGRRLFFDAALEAAQVSRASKRPVRLMWSRIDDTRHGRMRPATHHKIRATYGL
GQVLGFDHRVAAVETDFRHGLGEILTATAAKLPGGLGNAGFAQTLFHTTVKSPYHFGVTT
QRLTEVPLRMPTASWRSVYSANTRGAEEMLIDELAARMGKDPVEFRRTFLRNRAQRAVLD
KVAAEGAWGRPMPAGHAQGVGFHEEYKSRTACLVEIDATDPRRPRVTKAVIAADVGRAVN
PRGLEAQLLGGLTDAISTTLTAGLHIDKGLPLEGSYSQFHYARQKDTPPDVRIFVMPATG
EPGGAGELGVPAAVGAIGNAYARATGTRPRRFPVNFDVDFTPFPR
>A0A7W9U2Q1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bannensis|TrEMBL
MQFTLNGQPFDFDGDPDTPLLWVIRETAGLGGTKYGCGIGACGACTVHLEGEATRSCVLP
VSAVAGRNITTIEGLSPNTAHPVQQAWIAKDVPQCGYCQSGMVMAVAALLKQHPHPTDAQ
IDQGVTNLCRCATYHRIREAVHAAADH
>A0A0H4VWZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella hinzii|TrEMBL
MDTARFSRRSFLQGGLGALTLAVTSKGLITTVWAAETAARKYGADSMPGGTVDDPLVFVS
IAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWDRVKVIQAPADEARYGNQNVDGSR
SVRHFLMPMRRAGAAARQMLEAAAAARWAVPVAEVKAVQHEVLHLPSGRRLAYGELAADA
ARQPVPKGEALKLKERAEFRYIGKDKVRLVDLEAIGKGQATYGMDVRLPGMVYAVVARPP
VVGGKLRRFDSSKALALPGVLKVVEIPPMQGAPAFQPLGGVAVVARNTWAARQGRDALEI
EWDDGPNAGYDSTAYRQTLETAARQPGKTMRKQGDATQTWGRASEAERLAAEYYIPHLAH
ASMEPPVATVQIKAGKAEVWTSVQNPAAARDAVAARLKLEPADVKVNVLLLGGGFGRKSK
PDFVDEAAIIARAMPEGTPVKLVWTREDDIHHDYLHTVSVERLEAVLDKNGQVQSWLHRS
AAPTIASLFSEGAKGQQMFESAMSAINMPYRIPNVQVETAEVAAHARIGWFRSVANIPHA
FAAQCFIDELAHKAGKDPRDFALDLIGPARRIDPGTLADTWNYSESPERYPYDTGRLRGV
IEAACKGANWGRTLPKGHGLGLAFCYSFMSYTATVVEVAVDEKGGLRVVSVDMAMDCGPQ
INPERIRAQMEGGAIMGLSLALASEITFEKGRVKQSNFHDYEVLRHDASPRVIRTHLVND
DHALPPGGVGEPPVPPVAPALCNAIFAATGKRIRDLPVRRVA
>A0A8H2NTE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSINALSRRGFLKGSAVLGGGLVVAFAMPGAHRFAMGAENQGNVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGLPGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIHTESGVVIAGEHRATYGELADDAGQM
PRPDPASIKLKDAKDWRLIGKPTRRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPTFGG
SVKSFEGAEALAIPGVHKVVQVPTGIAVIADHFWAAKLGRDALKIEWNPGPNAGLDSQAL
LESFRKLATTPGINAGQAGDTQAALAKATRKIDVEYSVPYLAHAPMEPLNCTVSITQDKC
EIWTGTQFQTLDQMVAGKITGLKPEQVVIHTEFLGGGFGRRANPTSDFVSEAVYVAKAAG
APVKTVWAREDDIRGGYYRSAFLHHARIGLGADGLPLAWKHVMVGQSIMAGTSLEASMVK
DGIDKTSVEGVADSPYLEGLANHQIELHSPKTGISVLWLRSVGHTHTAFVMESLIDELAT
AAGKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLSFALHSKLTLKDGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPMAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E6WJH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNRINALSRRGFLKGSALLGGGLVVAFAMPGAHRFAMGAENQGNVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGLPGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIRTESGVVIAGEHRATYGELADDAGQL
PRPDPASIKLKEAKDWRLIGKPTQRLDTPEKITGRAKFGIDVQFDGLMTAMVARSPTFGG
SVKSFEGAEALAIPGVHKVVQVPTGVAVIADHYWAAKLGRDALKIDWDPGPNAGLNSRAL
LESFRKLAATPGLNVAKAGDTQAALAKAAKTIDAEYSVPYLAHAPMEPLNCTVRITQDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVLIHTEFLGGGFGRRANPTSDFVSEAVYVAKAAG
APVKTVWAREDDIRGGYYRSAFLHHARIGLGADGLPLAWKHVLVGQSIMAGTSLEATMVK
DGIDKTSVEGVADSPYLGALADHQIELHSPKTGISVLWLRSVGHTHTAFVMESLIDELAT
AAGKDPVEYRRTLLKAHPRHLGVLNLAVEKADWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQENLAIRVHRVVCAVDCGIAVNPRSIAAQMESCITFGLGFALHSKLTIRDGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGETGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E8H559|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11)|TrEMBL
MSVTLKINGETRTLDADPESPLLWALRDELGMTGTKFGCGIASCGACTVHWDGMPIRSCQ
TMVGDLEGAEITTIEGVNGKAAKAVQEAWNELDVPQCGYCQSGQIMAATALLTDTPKPTD
EDIDAAMDGNVCRCATYARIRKAIHAAADKMEA
>A0A5E7DEA0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSADGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAADIG
>A0A5E6RZI3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMTAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRASEIG
>A0A5E7EMB8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSLDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
TDIDQALSGNICRCGTYPRIRAAVKRAAELG
>A0A5E7VJN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSIKPLSRRGFLQGSAWLGGGLVVAFVIPGAHRFASGAENQGKVFAPNAFLRIGNDDSV
TVLLGHSEMGQGIWTGLTMLIAEELEADWSKIRVEHAPASAADYGLAAFGGMQITGGSTS
TWMEFDRYRQAGATARLMLIDAAAKRFNVAPSGIRTEAGVVIAGDRRATYGELADDAGKL
PMPDPASIKFKEAKDWTLIGKPTKRLDTPEKITGRAKFGIDVQFDGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVLQVPTGVAVIADHYWAAKLGRDALKIDWDLGPNTGLDSQAL
LENFRKLATTPGLSASKAGDTDGTMGKAVKTVDVEYSVPYLAHAPMEPLNCTVKITRNKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
EPVKTVWSREDDIRGGYYRSAFLHHARIGLDAAGLPIAWKHVMVGQSIMAGTSLEATMVK
DGIDKTSVEGVADSPYLTGLAHHQVDLHSPKTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVDYRRTLLKDHPRHLGVLNLAVEKAGWKAPLPDGHVLGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKDGQVEQSNY
HDYQVLRLNEMPLVEVHIVPSSEKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLA
GV
>A0A5E7T0W2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGIGATSALVLAASWGWQDALAEDKPKQFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVLHKPSGRELGYG
ELAAAASALPVPARDSLRLKQPSEFRYIGKEGSKAIDGADIVNGRAVFGADVHFDGMLYA
TIARPAVYGGKVKSVDDSAALKVPGVLKVLQIESRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQSPMEPMVAIARYKDGVCEAWAPSQAPQVTRERIAERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGEDPLKYQIKLLGADRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E6WM72|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGQDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGTPLRSCIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAELG
>A0A5E7FJK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVTTIDNLHADPVGKVVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7LEC4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNNLNPLSRRGFLKGTAVLGGGLVVAFVIPGGHRFAGAAENQGNVFAPNAFLRIGNDNTV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSTIKVEHSPASAADYGMAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIEAAAKRFNVPPSQIRTESGVVIAGDQRATYGELADDAGKL
PVPAPASIKLKEAKDWKLIGKPTNRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPVFGG
KVKSFEGAEALAIPGVHKVVQVPTGVAVIADHYWAAKLGRDALHVEWDLGPNAGLDSQKL
LESFRKLAATPGLPASKAGDTKAALAKATKKLDVEYSVPYLAHAPMEPLNCTVSITQDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVYVAKAAG
GPVKTVWAREDDIRGGYYRSAFLHQAQVGLGADGMPVAWQHVMVGQSIMTGTSLEASMVK
DGIDKTSVEGVADSPYLAGLANHQVDLHSPQTGISVLWLRSVGHSHTAFVMESLIDELAS
AAGKDPVEYRRTLLKEHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCIAFGLGFTLHSHLTFKDGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A7U3ZC85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica OS117|TrEMBL
MSTFTAVENISRRDVLKLFGAVGGGLALGASGLTWSPMALAQDKEARLNLFIAIGEDDKV
YLTCHRSEMGQGIKTGILQVLAEELEADWDKIVPIQGLADKRYASQNTDGSRSIRENYDR
MRQMGAMARTMLEQAAAARWKVPVSEVHTADHKVLHAKSGRSAKFGELALAASKQPVPAV
ESLTFKEVKDFKQIGASRQIVDMDAMLSGSAIYGYDIKIDGMLYASIMRPPVLGSDVASL
DDIAARKVAGVVDVYRLPAAKGAPAFQALGGVAVIATNTWSVLEGRKALKVTWTQADNSQ
HDSSLYLKELVERVQQSGNVVRQAGEEIKNWPEANTLKAVYTVPYLIHSSIEPPVATAHV
TEKGCEIWASTQTPQSTQQNVAAALGMEEDAIKVNVTLLGGGFGRKSKPDFSVEAALLSK
QFKRPIKVSWSREDEIQNGYYHAISAQSYQALFDANNKPTALLARTGFPSISSTFAEGVE
YPSGGELDLGFVDVPFALPNLRYEAVKAQAHSRIGWMRSVCNIQHGFSVGSFVDEMAHRS
QVSCPAMWRSLLGEARRETFTDQQFKYGNYGEDLDRHPVDVSRYFGVIDAVEKAQAKAPK
AGKNQGWGFAVHRSFVSYVAVAMLVEVSEDKQLKVLNAIAAIDAGTIVNPDRVKAQTEGA
IVFGLSLALMGEITYKEGKVQQSNFHDYPLLRIPQTPAIEIIIIESDAAPAGVGEPGVPP
VAPSLTNAIFAATGQRIRDLPVSKLLRV
>A0A6J5EGT3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia solisilvae|TrEMBL
MTTDIADVQRPARRTFLKGVGTAAALALTIGFEWGGLDRRALAAEAPAGSSTFAPNAFLR
IGADNSVTVIAKHVEMGQGAYTGIATIVAEELDADWSNVRVESAPADATRYANLAFGKIQ
GTGGSSAMANSWMQLREAGAKGRAMLVSAAAQQWQVPAASLRTERGVVYHDASGRHASYG
SLVAQASTLPVPDKVTLKDPKNFRLVGTRVPRVDVPPKTNGTAQFTIDVTFPGMLVALVQ
RPPQFGGTVRSFDATATKAVPGVVEVVQVPRGVAVVAKSFWAAKQGRDALKVEWDDTHAE
KRSSAAIMAEYRKLAEQPGLPARTEGDAAKAIAGAPRRISASYEFPYLAHAPMEPLDAVV
KLSADSCEIWAGDQFQTVDQANAARTAGLEPQQVKIHTLYAGGSFGRRANPGSDYIVEAV
SIAKALGANGTPLKLQWTRECDIHGGLYRPIYFHKLEAGLTNDGRLVGWQHRIVGQSIVA
DTPFSGLAKNGIDSTSVEGAANIAYAIPNLSVELATTRTGVPVLWWRVVGSSHTAYAVEA
FIDEAAHAAGQDPYAFRRNLLANQPRVRGVLDLAAAKAGWSDTPLPPGKGRGIAVAEAFH
TFVAQVAEVSVDKDGKVKVDRVVCAVDCGIPINPDVIAAQIEGGIGYGLGAALYGAITLK
DGRVEQNNFDGYQVLRMSEMPKVEVHIVQSAEAPTGIGEPGVAPVGPAVANAIFAATGKR
SYSLPFAVEKTA
>A0A6J4U4T7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Sphingomonadaceae bacterium|TrEMBL
KACATGFALSLWQSSERRAATPPSTTFRGTGSTRTARPEAEAFAVDGAVPPYGVAAVVVE
HVPVDVGAPSGVWRGRAHGYTAFFTECFVDELARKAGAEPFSFRMGMLGGNPRFARVLSA
AAALGQWDGGGAGSVQGIAAHAMAGSIAAAVVEAGVGADGRIRVSRVSMVVDVGRVINPD
LVRQQVEGGILWGIAAATGSPIDHRGGLPSARTLSELGLPHLTDTPDMRIEILPSLEAPG
GAEEIAVPPIAPAIANAIFAATGQRLRSLPLVMGGR
>A0A0D0QGA7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Wenxinia marina DSM 24838|TrEMBL
MATIIVNGTAHEVDAEEDTPLLWVLREQLGLTGTKYGCGIAACGACTIHVAGQPVRSCQM
QLRDLIEGDEITTIEGLSEDRSHPIQQAWIELDVPQCGYCQSGQIMAAAAFLRDFPEPTD
EDIKASMTNLCRCGTYNRIKAGIKRAAELS
>G2PSG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda ruestringensis (strain DSM 13258 / CIP 107369 / LMG 19739 / B1)|TrEMBL
MTLVKTKIGRRAFIRNTGLASGGLVIGFSWLASCKMTPEQVNSLPDEWFELNGFLKVGDN
GMVTIMSPNPEIGQNVKTSMPMIVAEELDIAWKDVLVEQAPLNTDIFTRQLAGGSQSIRQ
GWESLRMAGATARHMLKEAAAQAWDVSVDEITTKDGVLTHEASGNSAGYGEMASAATSIE
VPEEVQLKDNGSFSIIGTDKKNVDGKKIVTGKPLFGLDVYKEGMLTAMIVHPPAFGVKFK
SMNAESVKSMPGIKDVFHFEAYPEDVEKQWSDGGAIPELVAIVGNSTWECMQAKKALNVE
WEEVSKLESTSYHDEALASLLEKPQEEPARKDGDVDAAFKKAAKIVESTYSAPYLAHNTM
EPMNFFAHVTPEKAELLGPIQTPEFLEQTLVSRLGMPAEKIDVMMTRMGGGFGRRLYGTF
AVEAAAISQKMNAPVKLVYSREDDMTQGTYRPSYKVKYKAGLDENGNLIAWHVRGAGTND
DLIFENRFPAGAVDNYLAEKHSLETNVTTGAWRAPRSNFIAGAEQAFMDEVAEAAGKDPL
EFRLELFDRAINNPVGDPEKNDYDPERYAGVLKLVKEKSNWDTETGESRGVAAYYCHNSY
VAQVLELENGGGDMPRVNKVTCAVDCGIVINPLAAKNQIEGGIIDGIGHSMYSALTFEAG
KPEQSNFDTYRLMRNSEAPKNIEVFFVDNGIDPTGLGEPSLPPAIAALSNALYKTKGRRF
YKQPFINDKPPLVG
>A0A840FL59|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax guangxiensis|TrEMBL
MKRSNERPRPSRRPDDDDSPGLRRREVLGYATAAPLLSATAGLGSLTASSRAVAALLPMT
PPDTTDLIDIGDAVTVTSLPTMPLVKVTNAENGRVRLALPRLEVGQGIATATAMMLADKL
RLPLSAIEVTSADASPELIWNQLTGGSSSVRSLHAGMPLLGGLGGVLSGSTPSVVGQRVT
RLDALDIVTGRKKFTLDQAVPGAMPTMVRRPPTINGKFVSINNMNTVMAMPGVIGVVPIP
STNGITPTPPGVAVMAETFGQAWAAVNALDVTWAAGPIDGESNATLMRKLKSALLPFALP
PLGALTVEGEFEFAPVSHCPMEVECAIADVRPDRAEIWAGLQSPIVTQQAVAAELGLPLN
KVTVHVVPSGGSFGRRLFWDPVLQAIQVSKALGRPCRLMYHRTDDMRHTRMRPPMFHKAR
ATMLLGQVIAFEQRIAGVRLDTRHGFGNMLEAAAIALPNAFPQTVGNFAIEQIMFKTMVS
SPYNFGVTTKLLTPVPIDMNTCSYRSVHIQPSRLVEEILVDEMARAAGKDPVAFRLEYLR
LPRARAVLKAVAEAAQWGKAMPAGFAQGVGVHQETKSFTACIVEIDARVPSAAKVVRATI
AIDVGTPINPSGIEAQLQGGLCESIALVLSAGLHIQNGLPLEGSYSQYHFSRMKNYPKDV
KVIIMPPSNEAIGGLGEVGLSASSGAIANAYARATGIKPRSFPLNFPVDFTPIPPGKLPT
PVNVPIPT
>A0A484P7Q1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MRLSVNGQLHTVEAEPAAPLLFVLRNDLALNGPKYGCGLGECGACTVLVDGVAARACVMP
VRGVVGREVTTLEGLGDAACPGPTQQAFIECQAAQCGYCLNGMIMMIEALLRRQPAPDEA
QIRQELRHNLCRCGTHVEILQAARRAVTLHAQARETACAKRSGR
>A0A6C6YJC8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia mallei (strain NCTC 10247)|TrEMBL
MTTDLDLPDAVRASRRTFLKAAGAAAAVGLTIGFEWLDASRPALGATAPAAPAGDAAGAF
APNAFLRVAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWRDVRVESAPADASRYAN
LQFGKLQGTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWNVPAAELTTGDGVVRHAAS
RREATYGSLATAAAALPVPEQVALKSPSDFRLIGKPVPRVDARAKSDGTAQFTIDVSMPG
MLVALLQRPPVFGGKVKSFDASAAKAVPGVVSVVQVERSVAVVAKGFWAAKQGRDALKVE
WDESGAEKRSSDAIMREYRQLAERPGASARRDGDAEHALAGAAKRLRASYEFPYPAHAPM
EPLDAVVKLSADRCEIWAGDQFQTIDQGNAARVAGLDPSQVQIHTLYAGGSFGRRANAWS
DYVVEAVSIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHRLDAALSKDGKLVGWRHRI
VGQSILAGTPFEAVMVKNGIDQTSVEGAANLPYAIPNVSVELTTTRSAVPVLWWRVVGSS
HTAYAVEAFIDEAAHAAGKDPYLFRRDLLAHAPRLKGVLELAAEKAGWDPGKPLPKGRGR
GIAVAEAFKSYVAQVAEVSVDEHGAVKVERVVCALDCGTAINPDVIAAQMEGGIGFGLGA
VLHGAITLKDGKVEQNNFDGYRVLRIAEMPKVEVYIVPSGEAPTGVGEPGVAPIGPAVAN
AIFAATGKRHYALPFPAAGEATA
>A0A1Y5S541|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoruegeria aquimaris|TrEMBL
MSRVGKIARRTFLIGSAAIAGGVAFGVYAARQPFDNPNLDDLPEGAASFNPWVIVDSEKV
TLIAPHADKGQGIFSAQAALIAEELDIELDQVEVSFGMPDKAYYNRALTEAMAGFPLHDT
SPTAERVRGFVGGVVKLAMPMMTTGGSTGVPDSYDKLRQAGATARETLKLAASRQSGVPV
AELRTEAGAVILPDGTALPYTALAGLAATLPPVTDVPLRDPKEWRLVGKPMNRLDMVAKS
TGTLTYGIDHRAEGMLHAAIKVNPRQGGALKGYDASAAQAMPGVKKIVEITGGVAVVADN
TWRAFQAAEAIAFDWGEAPYPAEQAEHWAHLSGIFDDDHLNAEARVEGDVEAAEGEEVRG
EYRSPYLAHAPLEPLNATVLVTDDRVDIWAGHQIQMFAEQVVSEITGVDQENVHLHNMFI
GGSFGHRLEFDFIRQAAEIANQMRGTPVQLTYSREEDFAHDFPRHITMGRGVAKVKGGRV
TALDVQIAGQSVMRSQMGRMGLSLPGPDTQLHEGAWDAPYFNLPNLRVRSYRTEALAPVS
SWRAVGAGPNVFIYETLLDEAIHAAGADPLEERIRLMGHDVSVKVLEAVGELASWNGPSA
GPGRGRGVAYGFSFGVPVATIVEVAATDAGIRIEKAWVVADVGKVIDPVNLENLAQGGTV
FGLGHAINCEITYADGMAEQTNYHAHEGMRMYQCPEIRFKALENGAKIRGFGEPPVPPSA
PALGNAIFAATGQRIREMPFNKFIDFL
>A0A1Y5TG86|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoruegeria aquimaris|TrEMBL
MAITLKLNGTTHEVEADPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLDGEPVRSCQ
TYIEDVEGSEITTIEQMEEDPIGKAVQQAWAELDVVQCGYCQSGQIMSAVGLLRENAKPS
AAEIDEYMYGNACRCATYQRIRAGIQRAAEIMEA
>S9QIE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Litoreibacter arenae DSM 19593|TrEMBL
MTIKLKINGAERSVEAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHVDGEPTRSCQ
TYVEDVEGAEVSTIEAIGDDKIGAAVQQAWKELDVVQCGYCQSGQIMSAVGLLKETPKPT
LEEIDEYMDGNACRCATYQRIRAGIQRASEIVEG
>A0A2I6QNQ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured bacterium|TrEMBL
MTDDLELERYELFEGPAYRFSFNRRQFLKAFSGGIALIVPMSNLIAQQQEQQGESGRRSN
ERVPDDIGAWIHIDESGTVSAFTGKVEIGQNIRTSLAQAVADELHVPMTAVRLVMADTDL
TPFDLGTFGSLSTPRMAPQLRKAAAAARETLIALAAEQWKVAPADVRLVNARFVNHDASK
SLTLAEVAKGQKLVKTIPPDVAITPVRDWTIAGTSVPKVDGRAFVTGKHQYTTDLKREGM
LYGRIVRPSALEAKLVTCDTKAAETMPGVVVVRDGDFIGVVAPDRETAIRAEKAIAVHWQ
APGQPGNDELFEYLKKNVLPGNRGGTGRSPAESIAEGMAAADKKLAETYTIAYIAHAPLE
PRAAVAEWSDGKLTVWTGTQRPFGVRSELAEAFHIPEEKIRVIVPDTGSGYGGKHTGECA
IEAARLARASGKPVKLVWTREEEFNWAYFRPAGVIEVSTGVKNDGTVTAWEFHNYNSGGS
GIQVKYDFPNKNIEFHQTKSPLRQGSYRGLAATANHFAREVHMDELAHLINMDPVEFRLK
NIKDERLKAVLQAAAKTFGWRGKKTEGRGVGIACGFEKGSYIATAAEVSVDAKTGRVKIE
RVVESFECGAIVNKLHLHNQVEGAVVQAIGGALFENIQFKNGQILNGKFSKYRLPRFSDV
PKIEIVLLDRKDLPSAGAGETPIVGLAPAVGNAIFDETGVRVRSMPLAADDLVRRG
>A0A0H2WDU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia mallei (strain ATCC 23344)|TrEMBL
MTTDLDLPDAVRASRRTFLKAAGAAAAVGLTIGFEWLDASRPALGATAPAAPAGDAAGAF
APNAFLRVAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWRDVRVESAPADASRYAN
LQFGKLQGTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWNVPAAELTTGDGVVRHAAS
RREATYGSLATAAAALPVPEQVALKSPSDFRLIGKPVPRVDARAKSDGTAQFTIDVSMPG
MLVALLQRPPVFGGKVKSFDASAAKAVPGVVSVVQVERSVAVVAKGFWAAKQGRDALKVE
WDESGAEKRSSDAIMREYRQLAERPGASARRDGDAEHALAGAAKRLRASYEFPYPAHAPM
EPLDAVVKLSADRCEIWAGDQFQTIDQGNAARVAGLDPSQVQIHTLYAGGSFGRRANAWS
DYVVEAVSIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHRLDAALSKDGKLVGWRHRI
VGQSILAGTPFEAVMVKNGIDQTSVEGAANLPYAIPNVSVELTTTRSAVPVLWWRVVGSS
HTAYAVEAFIDEAAHAAGKDPYLFRRDLLAHAPRLKGVLELAAEKAGWDPGKPLPKGRGR
GIAVAEAFKSYVAQVAEVSVDEHGAVKVERVVCALDCGTAINPDVIAAQMEGGIGFGLGA
VLHGAITLKDGKVEQNNFDGYRVLRIAEMPKVEVYIVPSGEAPTGVGEPGVAPIGPAVAN
AIFAATGKRHYALPFPAAGEATA
>F4L4T3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MKIEFSINKKPVSIDVDPEMPLLWVVRDELQLKATKFGCGRAMCGACTLHVDGEVYRSCS
LPVQYAAGKEVTTLEGLSTETQIHPIQQAWIEEEVPQCGYCQPGFMMAAAKLIQEIPNPS
DEDIKSNISNICRCGTHPRIIKAIKRAAAIQQASKI
>A0A1D8QUB7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ascendens|TrEMBL
MIKFKLNGRDVSVDVPEDTPLLWALRDDLDQTGTKFGCGVGQCGACTVLVGGRATRSCIT
PISSLEGADVTTIEGLHPEGKHPVQEAWKDIQVPQCGYCQSGQIMQAVSLLKDYPDPTDE
QIDGVMGGSLCRCMTYVRIRKAIKKAAAAMQKEEASHG
>A0A072ZHL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MPTSLVLNGKNVTLDVDPNMPLLWAIRESAGLHGTKFGCGMAQCGACTVQLDGTAVRSCV
LPVSAVAGKRVTTIEGIQSKPGKAVQDAWVKLQVPQCGYCQSGQIMSATALLEQNASPSD
ADIDAAMNGNICRCAAYVRIRAAIHEAADTLKA
>A0A484SNZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRVGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPET
PAGWRALAFNGHVDLGTGIRTSLAQIVAEELEVPFDQLEMVLGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAAHWQVSAAALRARAGHIVFADGADPRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGALTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREV
PPAPDLSDLEAALRANRAEPRHLRDDGNAAHALATTPAARRLRRSYVWPYQMHASIGPSC
AVADHADGRLTVWSGTQNPHMLRVDLNRLLELGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLVDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGSVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGSDGLLRG
RGVAYARYIHSKFPGFGAAWAAWVVDLRVDPASGHITLDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPDIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRKALLARKQPGMPRADAPLSDTQPA
>A0A484QHD7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFIAVLDAPGT
PAGWRALAFNGHVDLGTGIRTALAQIVAEELDVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAARWQVPATALRARAGRIVFADEADTRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGALTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREI
PPAPDLGDLEAALRANRAEPRHLRDDGNTAHALATTPDTRRLRRSYVWPYQMHASIGPSC
AVADHANGRLTVWSGTQNPHMLRVDLDRLLDLGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLVDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGRVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGSDGLLHG
RGVAYARYIHSKFPGFGAAWAAWVVDLRVDPDSGHVTIDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPEIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRNALLARKQPGMPRADAPLSDTQPA
>A0A1X6Y746|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limimaricola soesokkakensis|TrEMBL
MVTLVINGEERQFDGDQDTPLLWVLRDEMGLTGTKFGCGIAACGACTVHIDGAPSFACVT
PIGVLEGAEVTTIEGLSEQGDHPVQVAWRDLNVAQCGYCQAGQIMQAAALVDQYDTVTDE
DIDAVMSANLCRCGTYPRIRAAVKQASAAKSGTSEAEAQ
>A0A4U8Z2W1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylocella tundrae|TrEMBL
MTVSFFLNDKEIALDADPNMPLLWAIREVAGLHGTKFGCGMAQCGACTVQIEGQAQRSCV
TPLESVKGQHVRTIEGLESKQAKAVQAAWVDLQVPQCGYCQSGQIMSATALLEQNAKPTD
ADINDAMRGNICRCSTYVRIRAAIHAAAHALEG
>A0A0S4TNR2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MVTLNINGKPVEIDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAVVGAQITTSEHIAEDKVGRAVLEAWIKHDVAQCGYCQGGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAAKALA
>A0A099CUH4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Oleiagrimonas soli|TrEMBL
MSVRLPLTRRRFLQVLAGATGALIVGVGRARAADADTPLALLGDDLTRLGPYVRIEPDGR
VILGARDPDCGEGTHTSLPRIIADELDADWTRVEVISLGPDLVSGNDNLRWRYGHQRSGD
GSSIPAAWEDLREAGALARWLLVQAAAQASGVAAANLRCENGAVIAPNGRRFDYGSLVKS
ALRQAPPQTAPPLKTPDDFRLIGRPAGDVDAEAMVRGEEKFALDQYMAEALTAVVLHCPW
PGGTLDSIDTQSALAIPGVRRVLQFQPEAGQPLGSTPIANGVAVLADDTWAALRGRDALK
LSWKPGKQADASTADLEQRARDLLQSQAEPTRHVREDGDFAEIAKHAPHHVEAMYVQPFV
AHATAEPMNCLVRIDTDRIRVVTPTQSPQEALTIVQRLTGMNAERIDVQVPRAGGGFGRR
LDHDFLTEAVLLAKAAGTAIKLVWTRDQDLRNDFYRPGALHRMQAVLDRRKRIVGWNVRK
ASASALAGRDVPADRLWTSEARPDALPAGLIANFSSTWYELDSPLPRGPSRGGHDVVDAF
ATQMFLDEIAHTVRKDPLELRMELLGEPHVLPGATANGAIDTGRLANVLQRVAARIDWNR
RRTNGHGLGIAFHHIDGAYCAHAFEVSVRGEKVIVHRAVCAIDVGRVINPLGLKAQAVGA
TVDGISTALGQTIQMRDGRIVQSNLRDYPLARMAQLPREVEVIIVASDSAPTGASIVAMP
STAPALASAVSAATTVRVRQLPLMPELLRKL
>A0A653Q240|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. 62|TrEMBL
MAKLSINGKTIEVAVEDDTPLLWVIREQIGLTGTKYGCGIAQCGACTVHIDGVATRSCSM
PVSALTAEQKIVTIEGLSPDGNHPIQKAWIEHDVPQCGFCQSGMIMAAAALLQSNPKPSD
ADIASEITNICRCGTYNRVKAAIKDVAAGGQMNRG
>A0A841ET62|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arcicella rosea|TrEMBL
MAKYSLKINGKTQQIDIDPSTPILWVLRDHLNMTGTKFGCGMAMCGACTVHLDGSAVRSC
SLPVSAVGKQAITTIEGLSANGTHPVQKAWIEHDVAQCGYCQSGQIMSASALLKSNPNPT
DEDIDNYMSGNICRCGTYLRIKDAIKSVKL
>S5UBU8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured bacterium esnapd4|TrEMBL
MPTYTFVVNGEPVTVDAPADLALLWVLRDKLGVRGPKFGCGIGVCRACTSHLDGAAIQPC
VTPVAECSGRSVTTIEGLASGADLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKETSEP
TDEDIDRIANVCRCGTYFRIRQAIKSAAAKMS
>I4KA36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas lactis|TrEMBL
MELRINQKAYQVDAEADTPLLWVIRDNLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAVEADDVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPAPTKA
QIDAAMVNLCRCGTYNAIHAAMDALAAGKETA
>A0A5E4RCB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea nosoerga|TrEMBL
MRELRFSRFAPFQGVAVGDYAGVSRRAFLKTSALAAGGLMLEMSVPGAMRTASAQGSAPA
PVVPSAFVRIAPDDTVTIQVNRLDFGQGVQTALPMLVAEELDCDWSKVRSELAPAADVYK
DPLFGIQMTGGSGSVAHSWLQYRRIGASARAMLMAAAAQQWNVPPAQLRTENGVVLGPNG
QRATYGSLAAKAQTLPVPAEVALKDPSRFRLLGKPTGRLDARAKSTGAPMYGMDFKLPNL
KVAVVARPPVFGAKVKGFDAKAARAVKGVRDVLEIPDDRGGTAVAVIADGYWQAKTGRDA
LKPTWDTAGVEHVDTTAQLTKYKEMARTPGIVALDADVSALKGAPKTLVAEYSFPYLAHA
PMEPLNCTVQLTEHGAEVWTGTQFQTVDQAAIARTLGLEPGQVKLHTLMAGGGFGRRAVP
TSDYGVEAAQVAKAWKRAGHREPIKVIWSREDDIRGGYYRPMYVHRAEIGLDAKGNVLAW
NHTIVGQSILQGTPFEKMLVKNGIDGTSVEGVSGTPYAVPLRLTLHSPQANVPVLWWRSV
GNTHTAFVMETLIDELAKNAGQDPVAYRYALMGDKHPRHKAALALAVERSGYGKTQLPKG
QAWGVAVHESFDSVVAYVVVAEIRNGSPRLVSATAGVHCNFAVNPLTVAAQVEGAALMGL
GTTLPGAAITLKDGEVEQSNFHQYTVARLTDMPAISVHIVSSGDAPTGMGEPGLPALAPA
YANALFTLTGKRQRALPFDMTTTA
>A0A7W8LDY8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia youngii|TrEMBL
MLTRRTFLLGGASALGGLLVGWGVLPPRQRLMTSTPLPTQGTQVALNGWVKIDTDNRVTI
IVPKVEMGQGIHTGLAMLLAEELDADWSQVHVEEAPIDRIYNAVQSIVDDLPFRPDDDSY
IRRGTVWITSKAVREIGTMMTGGSSSMNDLWTPMREAGASARVMLIGAAAERWDVPVREC
RAEQGYVLHPRGHKATFGELSSVASGQPLPRSVVLKQPADFKLIGQPVRRIEAASKIDGA
ARFGIDVLPNGLVYASVVMCPTLGGTVAHFDATPAQKMPGFIKALAVRPYAGGTGGVAVI
ADNAFHAMNAVEAINVSWHHGEAAKLSSTEVDRRLVDALDHTDGHVYYDIGNVDKAMTRA
ARKIEAVYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQMPRLARHHAAKVLDLDVDLVD
VQTQLLGGAFGRRLELDFVAQAAAIAREADGLPVQTIWSRQQDFTHDFYRPACAAWLQAG
FDEQGKLVAWHAKSAGQAIVPDALARYYDMPRIPIDKTTCEGAFDQPYEWPAARVSHKIV
ELPVPIGFWRSVGHSHQAFFTESFTDEAAAAAGQDPIEFRAMLLAQHPRHLAVLKRVEKL
SDWGRPLKPAADGARCARGVALHEAFGSVVAQVAEVSIGANRQIRVHRVVCVIDCGLPVN
PNLIRQQMEGGIVFGLSSALQNEITIVNGQVQQKNFVDFPVVRMNVCPAIEVDIMPSQLH
PQGVGEPGVPPIAPAVGNAVFALTGQRLRALPLRLA
>B9BMP5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD2|TrEMBL
MNLDVNRQAMNIDCDPSTPLLWVLRDHLNLTGTKFGCGVAACGACTVHLDGAAVRSCVLP
VAAVAGKRITTIEGLAESPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPTD
ADIDAAITNLCRCGTYPRVRMAIKRAAKALREGRA
>A0A0M7DIL6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MGHPANTPPAAEPIGLKVNGSVVRVAAPPATSLLLVLRNDLALNGPKYGCGLGECGACTV
LIDGVAARSCVIPVRAAQGREVTTLEGLGSRERPGSTQRAFIECQAAQCGYCLNGMIMTV
EALLRRDPAPSEQALRSELHHNLCRCGTHVEIMQAALRAVQLRAEAAPRGPEGAGA
>A0A1V5TRR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ignavibacteria bacterium ADurb.Bin266|TrEMBL
MSNSVKQTRREFIKVVGISGSGLILASFIPFNNVLANVGDDPKIFSPSVFLKIDSNGIVT
IIFHRSEMGQGVKTALPMLVAEELEVDWEKIIIEQSDADKKYGNQSTGGSTSVRRNWEPL
RVAGATAREMLILAAAKKWNTGTSNCYAENGFIINKSNGKKYSYGELVEDAAKLPVPTDV
KLKDPKDFKLIGKRVHRVDTPDKIFGKAIFGIDVVVPGMFYAALSRCPTFGGKVKSFDAA
KAKSMPGVVDVVEISNGVAVIADSTWRAFKGRDSLIIEWDLGPYANVTTEDIRNEMLKHV
KDEGAELENRGNINTNIKDEIKLDAVYEVPFITHAPMEPMNCVAKYQNGKAEIWAPTQNA
QDAQNETARVLGISKNDVTVHITLMGGGFGRRLVNDYVVEAAEISKACGKTIKLTWTREE
DMKFGFFRPPSMSVLKGSVTKDGKPAKFYHHVIAPSISQMRFNKNLKAEESDIADGTIDL
QYQIPNLKITGTLIPTHVPISWWRAVYNSQNPFAVESFIDEMAYAANKDPFIFRKEMLPS
DSRLANVMNVAVEKAGWQVGKKLPAGKGMGIAIFSGYESYCAQIAEVTVNNNKLKIDRYV
AVIDCGIVVNPDTVEAQLEGAIVFALSAALKSEITIQKGGVKESNFDDYPMLAYDETPVI
ETYYIKNTYKVGGVGEVGIGACAPALTNAIFAATGKRIRRLPVKLI
>A0A0D1EL69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia aquimarina|TrEMBL
MSAGKIVRRTFLVITGAVGAGIAFGAWRYLRDPGNPLTEGLAEGEAAPNAYVIVDADGVT
LVAPRADVGQGAASIQAHLLAEELDVDPHAVRLTPGPASGVYWNGIVAGEGMPFAGWDDA
WSSRTMRGRGADIAGKLVGLHLTGGSTTVPDMYDRLRVAGASARETLKLAAARRAGVNVG
DLRTEDGTVILPDGGTIPYGDLAADLAGMEAVQDVDLRDASEWRLLGRELRRTDIVAKST
GTFTYGTDIRLPGMIHATAVTNPARGGGVARLDDVSARLLPGVEDVVPVEDGFAVLSTSD
WAAIRGAREVDVTWGTPAYPATSDEMWGAHAAALDDDGTRDSRFRDDGDVVAAPGTAIEV
EYRVPFLAHAPLEPSNATVIYTPERTQVWTSTQAPTFLRDAVSRMTGQPPEAVEVNALPG
GGSFGRRLEDDQVRPAVEIAKTRPGTPIRMTWTREQDTACDYFRPMALARGRATHEGGRV
TGLDLSIAAHSVAESQLTRQGFPPIGPDVAITAAAWDAPYAIPSFRVSGYRVPAGVGVSS
WRSVGASHNGFFLESLLDEAIHAAGADPLEERLRLMDHEPSARVLEAVAEMAGWDGPRDG
RGVAFCYSFGVPCAQIVEVEQTDRGLRLTGLWVAAEVGRILDPVNLEAQLSGGALFGLGH
AMHSEITFADHVPEQRNFDTFLSLRQYEVPPVRVRALETTDLIRGAGEPGVPPAAPALAN
AIFAATGERLREMPFDRSVRFA
>A0A7W5FUY3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia violacea|TrEMBL
MITLNINGRDTQLDADPSTPILWALRDNLNMTGTKFGCGAALCGACTVHMGGQAIRSCVT
PISSAVGQKITTIEAMEGDKVGKAVQNAWVKHDVPQCGYCQSGQVMSATALLKTNKSPSD
ADIESAMAGNICRCGTYQRIRAAIKDAAKSLA
>D4DXT3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera DSM 4582|TrEMBL
MTKVSDSHDREAFPTGEPVNISRRRFLLGAAGTMAGALVLGFGLPVRQVRAQTPGNHAAP
GTHVPAFLEIRPDNTIRLQSPFIEGGQGIFTGMAQIVGEELDAEPMSFIVENAPPDAEYT
VMENGLRITGGSMSVRMSYSTMRRLGALARHMLLQAAASQLGVPLDTLTTEPGRVIHQAS
GRSLRYGQLAPRATRAAGNSRRGQWNCRCQMLPA
>A0A840R7Z8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania antarctica|TrEMBL
MLTIQVNGVSHTVDAPEDKPLLWVLRENLKLTGSKYGCGQALCGACTVHIDGQPTRACVM
PVGAVGNKAVRTVEDIRNEHIGSLVQDAWRELNVPQCGYCQSGQIMAATALLKSNSAPSD
QDIDRAMSGNICRCGTYPRIRKAIHKIASEQL
>A0A8I1YFJ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MLPRTHKDAAMNQHIMPKLNRRAFVIGTATAGAGLALGLDLPFGGPAVVRAADGAPEVNA
WVVIRPDDTVVIRIARSEMGQGTLTGLAQLVAEELECDWSKVTTEYPTPGQSVARKRAWG
DFSTGGSRGIRTSQDYVRKGGATARVMLIQAAANEWKVPASECKAANGVITHTPSGKTTT
YGKVAEAAAKLEPPADVKLKDPKDWTIAGKGLKRLDTVDKTTGKMVYGIDVKLPGMLNAA
IKDCPVFGGKVKSFDEAKIAGMKGVRKVVQVGDSAVAVVADTWWHAKTALDALPIVWDEG
PNAKVSSETIATWLAEGLDNAQPAYIGNQNGDAKAAIAAAAKKVEAVYNYPYQNHATMEP
MNATVLYTPDKCEVWCGTQNGEAAFAAALEASGLPAEKVDVHKLMLGGGFGRRGMTDYVR
QAVAIAKQMPGTPIKLLWSREEDMQHGKYHPITQCKLTGAFDADNNLVALHYRLSGQSIL
FSVRPEALQNGMDPAAFQGVAQAGEAAIGYSVPNLLVEHSMRNPHVPPGFWRGVNVNHNA
IYMECFMDELALSVGQDPLEFRRKLMGKHPKHLAVLNAVAEKIGWGTPAPQGVYRGIAQV
MGYGSYVAGAAEISVTDGSKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGG
CTVKDGRIEQTNFDTYNSMRINEMPKVEAVMVPSGGFWGGVGEPTIGVAAPAVLNAYFAA
TGKRIRSFPLRNQNISFA
>Q92WL0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium meliloti (strain 1021)|TrEMBL
MVTVKINGVEHKIEAEADMPLLWAIRDLVGLTGTKFGCGMAQCGACTVYVDGSPTRSCQT
FIGDIEGAEVTTVEGLKGKVAETVQAVWADLDVPQCGYCQSGQIMSATDLLANNPKPTDA
DIDAAMSGNLCRCATYHRIRAGIHEAAKRLEA
>A0A7W8PAL9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. HC6.4b|TrEMBL
MELIVNGVHHNVDADANMPLLWAVRDLLGLHGTKFGCGVGACGACTVHLDGVAVRSCVTA
LADVQGKPVTTIEGLGKGGDHPVQRAWKAANVPQCGYCQPGQIMQAASLLKQTPKPSDEQ
IVEAMSGNVCRCGTYQRIKAAIKAAASEA
>A0A2U3KB66|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MSPLSRREFVAIGAAAGAGLVIGFYLPHDAGSKRDSFSPNAYLRITPDNKVTIVVARSEM
GQGVRTALPMILAEELEADWKQIEIEQAGASTLFGDQTTGGSASIHTCWDPMRKAGAAAR
EMLISAAALTWGVPRSACTAENGRIQHATSSRSASYGELAGQAATLPVPTDPPLKQSKDY
KLVGQRLPRLDSPAKVKGEAVFGIDVRVPGMKLAVLSRCPTIGGKVSGFDDKDSKKISGV
SYVGKVGESAVAVVAGSVWAAMEGRRVLNVTWDDGPNKNLNTATVITSLRQAASRKAASI
YLAGDPAKTSGRHISAEYELPFMAHAPMEPGNCTAHYQGTKCELWAPTQVPQDCRDAVAQ
AVGLDPDQVKVNVTLMGGGFGRRLEHDYAVEAALVSKAIRAPVKVLWTREDDMRFSTYRP
ASFHQLSATLDGSGFPIALTHRIVAPSISGQRGQPGPNNLDPDLPDEAGPVYGISNYSIE
YVMIETPVPLGWMRSVYALQAAFALESFIDELAVAAGKDPLEYRLHLLAKDQDLQFFTTT
WHTARMRGVLQTIAEKAGWDKPLPAGRYRGAACFGCFDSYMAEVVEISMENGQPRVHRVV
AVVDCGQVVNPSILEQQIQGGIVYALANALRARITIKNGGVVEGNFDDYAPLRMEETPAV
EVYAVPSAEAPTGIGEPSVPPLAPALCNAIYAATKKRIRALPVLS
>A0A2U3KBJ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MLSSFWTNMANLTLRVNGSEKKVDVSPETPLLWVLRDTLELTGTKFGCGAGLCGACTVHV
DGDAIRSCLTPVSQVAGKSITTIEGISVNGLHVLQAAWIAEEVPQCGYCQTGQIMSAVAL
LAKTPHPTDEQITQSMNGNLCRCGTYERIRKAIHRAAADGGAR
>A0A084Y6M5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Accumulibacter sp. BA-91|TrEMBL
MPAFCPRRARQAQGLNELAGLDHRRGQGVDTCAVYFNPLQESLMLQIKVNGQPRQVDVAP
DTPLLWVLRDTLQLTGTKYACGQALCGACVVHVDGVPARACLTPVSAVAGREITTIEAAH
QSRVGRAVQAAWRKLDVVQCGYCQSGQIMSAIALLGRQRKPTDSDIDDALSANLCRCATY
QRIRAAIHEAARSLA
>A0A852VVB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janibacter cremeus|TrEMBL
MSSHTFVLNGEKVTVDVEPGVRLLWVLRDVLGVTGPKYGCGINVCKACTSHVNGKAMNPC
SVPVDQISPDDEITTIEGLADTVEKDLHPMQEAWIEHDVAQCGYCQPGQIMAAVALVRKV
REEGRAISEADLDGIRNICRCGTYTRIREAIRTGEQHM
>J2EK10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens Q2-87|TrEMBL
MSRLPNDFVLSNLSRRGFLKGASATGVLVLAASWGLPDAFAEEKKYGAEGMPHGAVDDPK
VYVSIATDGSVTVICNRSEMGQGVRTSLSMVVADELEADWALVKVQQAPADEARFGNQDT
DGSRSMRHWYEPMRRCGAAARSMLEQAAAAQWNVPVGECRAQLHKVVHQPSGRELAYGAL
ATAASALPVPARDSLRLKQPADFRYIGKEATRAVDGADIVNGRAVFGADVHFEGMLYAVI
ARPPVYGGKVKTVDSSAALKVPGVVKVVQIEGRPLPSEFQPLGGVAVLAKNTWAAIKGRE
ALKIEWDDGPNAGYDSIAYRKELEAAALKPGKVLRNTGDLDDALAKADSSLEATYYLPHL
SQSPMEPMVAVARFKDGQCEAWAPSQAPQVTRERIAERLGIAFDKVTVNITLLGGGFGRK
SKPDFVVEAAVLAKEFPGQAIRVQWTREDDIHHSYFHTVSAEYLKAGLNQDGMPSGWLHR
TVAPSITALFAPGMTHEAPFEVGMGLTNMAYAIPNLRLENPEAVAHTRVGWYRSVSNIPH
GFAIQSFIDELAHKAGQDPLKYHVKLLGPDRKIDPRTLSEEWNYGESPERYPIDTARIRV
VLETAAKAAGWGRQLPKGRGLGLAVHYSFVTYVAAAIEVEVKDDGTVIVHKADIAVDCGP
QINPERIRSQFEGACVMGLGNAMVGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHLVT
PPGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQQAKA
>A0A6S6ZF82|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter kerstersii|TrEMBL
MVDFSVNGQKVSVQAPADKPLLWVLRDELKLTGTKFGCGVAQCGACTVHINGQPTRSCVL
PVSTVAGADIMTIEGLVRTDIGKRLYEAWIDHQVPQCGYCQSGQLMTAANVIAAATVPLV
RAHVLEKMQGNLCRCATYNQIASAVISAGKTTDSGAMNAK
>A0A7X5V2G8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas leidyi|TrEMBL
MKVDFGKLQKLDRRTLLIGGGVGVGLVVAWAVWPRTYLPNLTAAPGESLFGAWIKIGTDG
HVSVAVPQCEEGQGVFTAMPQIIADELGADWKLVGVEPAPLNPLYANPLAAEELFEQALG
GLPEQLRRSHAARTGLVLTGCSTSIRSFEDQLRHAGATARVLLCKAAARRWGAEWQSCDT
AGGQVIHGNSKLGFGALAAEAADERVPGDVPLRTGEANRLYGQELPRLDAPAKVDGSLLY
AADVRLPNMVFASIRMGPIGETELVKLDRAAADRIPGMLSIVTTRDWVATIANNGWAAER
AIDAMRPRFKTPEEVINNDSIASALSDALNADGARIHEAGDLAADFRGAKVVSAEYRVDV
ALHAALEPMTCTANYHEGHLSLWLPTQAPGLARAAAARAIGIAESSVTVHATMAGGSFGA
KLEHAVAEQAALLAERIGRPVQLTWPRGEDMRHDRYRPPAIGRMTGKLNPRGQVSGLLAK
IAAPETGRELATRLLGSDPVVQASLALPGKGDPSAVAGARPFYAIPNYAVDHHVAAIGVP
TGYWRSGAHSYNCFFVESFLDELAHAAEQDAVSFRMAMLGGGTRLARCVQMAAQLGGWQG
GQPGSGQGIACHAFRGSYVAVMAEARLDGRKVKVERLVAAVDCGRVVNPDLVTQQIEGGL
LFGMAAALAGSTGFTENVADVRDLSELGLPTLADAPDITVELIRNAADPGGVSELAVPPV
APAIANALQSASGVRFRVLPLLSDVE
>A0A7W7WEE8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kitasatospora gansuensis|TrEMBL
MRMLTCGPTPPKIGPLFTPWPGKAPEISSTPQALGRRRFLTYLVAAPALAVGAQLAVDPE
PAEALPRLPGLPGLPSLADLGDVLILAGLPTTHLLVLEVTEAGRVVLQLPRVEVGQGLTT
AMAMLVADELDAVLTDVDVPLSPARPELLFGQLTGASNSVRSLYDPVRAAAAAARARLVT
AAARRWNLPADGLRTQDSRVIAPDGRSAGYGELAVAAAAVVVPAVSTQPRPATQQRLVGR
PTGRIDARDIVTGKAKYAGDLDVPGAVPAVVLRPPTVKGTVRSWDGAAARAMPGVLDVLA
VPTGIAILAETFDQALKAKAAVQVSWNPGPLAALSDADVRTKLRAATAPFLVPPLLSLSL
DAEFDFAFVSHAPMEVLTAVADVRPDRAELWFAAQSPIASQQGIAAILDLPVSAVKVNVV
RAGGSFGRRLFADAAVEAARISQAARRPVKLMWTRNDDIRHGRVRPASHHRIRATHLLGQ
VLTYEHRVCTVRTDFGHGLGEILTAAGASIPVGEELFSQVFFDLTQELPYELGVTTQELT
EVPLDIPTGSWRSVYSGLVRVADEVMVDELARTLGRDPVAFRRARLRDAGARAVLDKAAQ
AGSWGRPMPAGHAQGIAFHSEHRSSVACLVEIDATDPAEPRVTKAVVAADVGRVINPRGL
EAQLLGAVTDGISVTLRAGLHLDRGAIREGSYADFHYARQRHSPLAFEAHLMPPSGPPGG
AGELGVPAAAAAVANAYARATGTSPRSFPINF
>A0A7W8E3M6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Granulicella aggregans|TrEMBL
MAIGLMEAAPNAEQMQEGLSLPSGIKPSRRQFLVSATGGFMLQFCLPGLSRFASAAGVPA
PTAINSYIQIGTDSRITVLFGGCELGQGAMSGLAQIAAEELMVEWTQVKSALAPLGPITY
ITGGSSAIRNNYLPLRQAGAAVRMMLIRAASNHWGVSVNQCYANNGTVIDAPTKRVLTYG
ALALAASKLAPPAKPTLIPDAALRLIGKPLVRLDMADKTNGRAIYGIDVRLPGMVYAAVR
HAPMLGGTLASTPTNRNGVTFVNLGTAVAAVAGDTHSAFSALGEGDDDGGGSGGGGFKWT
TPPNAAQIASTVFATQAATIMKQGPVLESEVVGSALAAKSTSTTTIDATYSVPYLAHACL
EVLNCTVNLTPTFCEIWAPTQVAGWAQAAAAAITGLPLAAVKVNVTYLGGGLGRKLETDC
IVQAVQIAKAIKKPVKLTWPRQEDFQRDKYRPMAVSYLRGSLDSSHNIVAWWNRVVTPSI
SAQKGFITAGAEDGGAVEGAVTLPYAMVNRLVEFGPHPSPVPIGWWRSVGVSYNAFFVES
FIDELAHATSQDPYQYRRRLLVNNPRFLAVLDAAAELGGWNTTLANGHARGIAIAETFGT
VVAQVVEISGASATGLRVVSVACAVDLGRAINPDSIEAQMQGGIVHGMGAALWGHITFAN
AAASVQNFNTYRLVKMSDMPTIKVKILPSTNPPSGAGEPGVPPFAPALANAYFRATGIRA
RSLPLFPAASHMGD
>A0A238L0D9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria arenilitoris|TrEMBL
MATTLTINGKPHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVQIDGEAVRSCQ
VTLSDVWGEVTTIEGLGTPDNLATIQQAWVDHQVAQCGYCQSGQIMQAAALLAENPAPSD
EEIDEAMQGNLCRCGTYPRIRAAIHDAAAKLKEA
>A0A839VZV8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum sp. OGB3|TrEMBL
MIRLNINGQDRDVDVPGDMPLLWVLRDELNLTGTKFGCGIAQCGACTVHMDGTPVRACQT
PAESAAGTKITTIEGVSGKAAEAVQAAWQKLDVVQCGYCQSGQIMSAVALLTDNRNPTDD
DIDAAMDGNVCRCATYPRIRAAIKDAAKAMGA
>A0A839W0I5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum sp. OGB3|TrEMBL
MLNQLIKQAAADVAAPSRRGFLKGAGGALVLGAMLPRTGFASEAAAPKVVGPADPRPQAF
IRIAADDTVTVLVKHLDKGQGIMTGLTTIVAEELDADWAQMRGAFAPADGALYANHFFGI
QGTGGSTAVANSWDELRMAGAAARAMLVATAAARWSVPASSVTVDKGVVRHAASNRSARF
GALAEDAAKLPVPQNVALKDAKDYTLIGNPSLHRLDHVSKTDGTAIFAMDIRRPGQVTAV
MARSPRFGGTVKSVDAAAAKRVPGVLEVLTVPRGVAVVAKNTWAAMKGREALTVEWDDAK
AEMRGTEEMLADYRKLADQPGNVATDTGDAAKALAGAAKVVEAEFVFPYLAHAPMEPLNA
TVELNPDGGCTIWAGSQFQGVEQKVVAAMLGCKPEQVVINTVWAGGSFGRRATTDADYIA
EAVSIAKAYGKAPVHLVWTREDDIRGGRYRPLFLHKVKAGLDAGGKLVAWRQKIVGQSFM
AGTPFEAVMVKNGVDATSVEGSSDMAYAVPNLYVDLHSPASPVTTLWWRSVGHTHTAYAK
EVMIDELAAAAGKDPVTFRLEMLKDHPRLQGVLKLAAEKAGWGQPLPKGKGRGIAVHESF
SSFVAHVAEVSVDEQGRVTIDRVVCAVDCGQVVNPNIVEAQISGGTGWAIGHALRDEITL
TGGLVDQSNFDTYQPLRNSEMPPVEVHILPSTARPTGVGEPGVPTAAPAVANAVFAATGK
RLHHLPFTRSGMV
>A0A085FYN8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. LC238|TrEMBL
MKFDWIDRAAAARAAGAGLSRRGFLKTAGAATGGLVLGFTLPGAHRFAQAAEAKVYAPNA
FLRVAPDNTITVMVNRLEFGQGVHTSLPMLIAEELDADWSQMRGELAPAGEVYKDPAFGM
QITGGSGSIAHGFTQYREIGARARAMLVAAAAEQWKVAPGQCRTSKGMVLGPNGQKASYG
SLAEAAMKQPVPATVVLKEPKAYRYIGKPMRRIDARAKSSGRQQFGIDFTPEDALTVLVA
RPPVFGAKVAKFDAAAARAVKGVVEVLEVDLDRGARGVAVFATGYWPAKQGREALQAEWD
TSGLEKVSSAQQLEEFRKLAKAPGGALARKADVSQLAGAAHKISAVYEFPYLAHAPMEPL
NCVVDLKIDSCTIWAGTQSQTVDQQVAAGILGLKPEQVTINTMMAGGGFGRRAVLASDWV
GDTVRIAKAWRAAGKSGPVKLVWSREDDIRGGYYRPSYVHRADLGIDGKGRIVAWDHKIV
GQSIMAGTMFEQGMVKDGVDGSTVEGMGAPYDVPLNLAVEGVKQNVPVLWWRSVGSTHTA
YVMETLIDEAAHVARMDPVAYRKKLMGEKHLRHRAALDLAVAKSGYGTKKLPKGRAWGVA
VHESFGSVVAYVVEASVVDGVPKLHRAVAGVHCNQPVNPLSIEAQVQGAALMGLGMTLPG
AAMTLKDGVVEQQNFGDYVVARHHEMPQVEVHIVPSNDPPTGVGEPGLPPLAPAFANAVF
RLTGKRLRKLPFDLATA
>A0A7W9W5C8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Armatimonas rosea|TrEMBL
MNRRDFFKATALIGGGFALGLYSDSETPAQAQPPRQGPPPLEPSAFIKIAADGTVTILSR
APEIGQGMKTTLPMLIAEELDIDWKSVRVEQADVDPRYGGQFTGGSGGTPSGWEPVRRVG
AAARALLIAAAAKEWGAAEADCHTASGEVFHTATNRRLGYGALAAKALAMPLPDPATLKM
KDPASYKIIGKPTGGVDVPKIVTGKPLFGIDVHLPGMLYATFHKTPVLGGKVVKANTEAV
AKLPGVKKAFVVEGNPGVGLESGVVIVAATWWQAQTARKQLEVTWDEGKWASYESKEHFA
KAAELLGKTPARTVGKVGDPDAELEKAAKVIEARYAYPIIAHAPLEPQNCTALFKDGKLE
LWSTSQIPTGGRSGSARVVGIPESAVTMHLHRAGGGFGRRLYNDMVVDAAWIAKEIAGVP
IKLLWSREDDFAHDYYRAGGWHHFKIGLDASGKTVALHDHFVGYGENDRFVDSGGVGPGE
FPVRTIPNYALGLSMVPLAVRTGALRAPGSNVHAFIFQCLTDELAHAAGKDPVAFRLEQL
AALEALPGNQRGMDIERMRTVLNLAVERSGWGKKTLPKGTGMGVAFYFSHSGYFAEVVQV
KVSAKKAIKVEKVWVVGDVGHTIINPVAAESQVCGSIIDGMSQMMAQEITLAKGRVVQEN
FSEHPMVRLNEAPREIDVHFHKSNNRPTGLGEPALPPILPAIANAVFAATGERVRTLPLA
KSGYSWG
>A0A5P8Z506|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax sp. THAF197b|TrEMBL
MASFTVNGKSVTLDVDDDTPLLWALRDELRLTGTKFGCGIAQCGACTVMLDGAPVRSCQT
QVGTLDGAEITTIEGLDGPEAKAVQDAWTAIDVPQCGWCQSGQVMSATALLRDTPKPSDA
DIDNAMWGNVCRCATYTRIRAAIHDAADTLEG
>S9RZT5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger mucosus DSM 16094|TrEMBL
MNFRRPMVASYARTVRTLPTQSWFPKSRSCWTPVWPKYPPRPRSTTGAKLLRRPLVPPGR
IRNSKQSSPDALHTAGTSYAKKCSLARSAHPPHLGARLLAADRNGALSVTGVIDVVVDTE
ANFAGIVARDPFVLDASLEKLAPRWSAEKDGAEDLQDFMNSVHLQQTESFEHELVEEGSG
NTSSEEEIRTISAEFRTSMAAHAAMEPRAAVADVGPDKAEIWCGTQDPYFVRARIAALLG
RRRADIVIHPQRMGGAFGGRVACGAAEQATRLSAMVGRPVRVQWDREAEFRNSYMQPPFA
HRVSAEVNAAGTLTRWMQDFVSAPITTGPVSALGDGMSQFIAAGIDWFSADTGTARGAEH
PYSAAIQRIRYSDIRTDLPFGPWRGLGAGPNTFVTESVMDELAEAVDMDPVAFRLHNLAS
GHDRLAHVLKRVAKLSGWAGRASQEASTGAQGVACGIYKGMTYVAAVAQIEALHAQREIR
VRKVWCVQDCGCVVNPDQVRAMIMGNIVWGCGMALKEELTLDGTSVRQDNFDTYEIMRND
ACPDVEIELVPSEEPPAGAGEAALVSIAPAITNAVHAATGNRIRRLPIRSEDVFI
>A0A0K8P7I2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MDLLVNGALRPLPDELADPAMPLLWVLRDLLGLTGTKYGCGVAACGACTVHVGGAPVRAC
VTPLSAVGRQPVRTIEGLAGSNPHPLQQAWIEHQVPQCGYCQSGLLMAAAALLARNPRPT
EADIDAALTNLCRCGTLPRVREAVLAAAARLRGERLPAPPLRA
>A0A3S4G2T7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MNLRDHELAALGEQPVNLSRRRFLLAGGSLAGVLVLGVGLPVGQGRAQTAQASPAPGTRV
PAFLEIRPDSSVKFLSPFIEGGQGIFTAMAQIVGEELDADPATFIVENAPAGSEYQVMDS
GMRITGGSQSVRSSYTTMRRLGALARQMLLQAAAAQLSVPVEQLHTEPGRVIHALSGRSL
SYGELAARARDLAVPSPDSVTLKDPARFRWIGKPVQRLDMHEKSTGKAVYTIDCRVDGML
HAAVQHAPRLGLHAGQLRNEEQVKAMKGVHSVHVLPGAVAVVAERWWQAKRAAEALQVEW
LEPDAPDGNYMPADFSSEAFAAALAQEPGEGEDAEVKGDSAQAMSAAQTTLSATYHSQYL
NHAQLEPPSALARFNDDGTLELWIPNQAPEMFQADVAKRTGLAPEKIIIHSPLLGGFFGR
HFVYDTAMVYPQAIALAKAVGRPIKLIWSREEEFLRDTHRPMAAVRFRAGLDAEGYPVAL
EAISICEGPTEAQTGKHGDQLDPSALEGLTGKAYAIPNVRIAQIYKKGPVRLGYWRSVGN
SMNDFLYECFLDEIADKSKLDPFALRLHLLQGNQRLTTLLNAVAEMSGGWQAGPYTAADG
SRRARGVAMASPFGSEAAAIAEVSIEQGQVRVHQVWEAIDPGSIVNPAIIEAQVNSAVAL
GLSQVLLEESVYEKGQPVARNYDMYPILPPSRMAQVQVRIIESGAKMGGIGEPPLPAIPP
AVANAVSRLTGERIRSMPLSRFNFS
>A0A2X5AXH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MELDINNKIYQTDADADTPLLWVIRDDLAMTGTKYGCGLAQCGACAVMVDGQAVRSCVTP
LETVAGKKITTIEAIESDDVGKRVVAAWVRHQVPQCGYCQSGQVMAATALLKHNAHPSDE
EIAAAMVNLCRCGTYNAISAAIHEVAGEGDNA
>A0A653JU55|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus sp. 109|TrEMBL
MAAEPDIAQPDQPASGLNRRKFLIGGGALGGLALAWAIWPRSYEPNIAATENEQIFGAFL
KISEDGQVTVVVPQSEMGQGVYTVLPQILADELGADWRTVAVEPAPINSLYSNIPLAEQW
AESLMPAGSKKLTENAAVQWIAQNVAVREQFMVTADSTSIPAFAASFRDAGAAARVLLTK
AAAERWDVPWEACTVENGMIANGEKSLRFGALVREAASQNLPDPVPLRTAGAGSLIGQDV
PRLDLPSKLDGSANFAGDVRLPDMVYAAIRQGPIGETRLKSFNRAGAGKITGFIDVVEGD
QWIAAVATNWWAANRALDKMSPIFETRGFMADSERIDGFLQKALDDGPGTRFLSRGETSG
LFTEENLVRARYHANAALHAPIETRTATAEYKDGGLELWMATQAPVAAVQAAARALNIQQ
DRVTLYPMLSGGSFDRNLDNEIAAQIALIARKMGRPVQLMWSRAEDLMHDHFRAPSQARL
DAAMAKGGRVEALQIKIAAPPTGREQVKRLFDGLGNAEAMRSSIGDADSKAVEGLDIPYD
IANLTVDHHSAFVGVPTGNWRSNAHSSNVFYLESFIDELAAKAGVEPLSFRMQMMNNAPR
LARCLTSVAAMAGWDGGLDRSGQGMACHSMRGGHIAIIASASRGGSGLEVRRISASVDIG
RIIHPDIARQQIEGGIVFGLAMALGSATRFEKGLPKARRLRDLSLPRLAEIPPIQIEFVR
SEEESAGYEELGVPAVAPAIANALFSATGARLRQLPLFGEIS
>A0A165UCF3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. Ad26|TrEMBL
MAISLKLNGQTHKVDAEPGTPLLWVIRDELMLTGTKFGCGVASCGACTVHMDGEPVRSCQ
TFIEDVEDSEITTIEGLKSSPAQAVQQAWTELDVVQCGYCQSGQIMSAVGLLSENAKPTL
EEIDDYMDGNACRCATYQRIRSAIVRASEIMEA
>A0A160NUB1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces laurentii|TrEMBL
MDAQDRAAHHEEGPRQRPERQRRGEGDDGAPSSRGIGRRRFLGYVLAAPTLTVAAELGEQ
VLAPTPAAAAETAVVPAVVPSLPGPADIYDLNDMLTHAALPTANLITIRLDPDGTAHFAL
PRAEVGQGITTSTAMLIAEEMDLPLDRIKVTLADARPELLFNQLTGGSNSTISTYTPVRV
AAAVARGRLLRAAALELGAAVGTLTAKAGVITSAAGVRLTYGELAVKAAALTDTQVSVAL
KEPEQFRVIGTAQRRLDALEAVTGRKKFAMDVQVPDALPTMVCRPPTINGTVRSVANLAE
VRAMPGITDVVTVPTGVAVRGRTFGQCIDAVRALRVTWGPGTAEGASDATVLAELRKAEL
PLVVPPLDLITKAVDTRFTFHFASNSALETNCAVADVRPGSAEIWASLKSPIVAQEKIAL
QLGLPVGAVKVHVTEGGGSFGRKLFHDAAGEAAAISRAMGKPVRLMWHRTDDFRQGRTHP
MATSRVRATYALGQVLSYEQRHTSVATDFGHGLGEIITSEVARLPVADLTFSETMYQLTQ
STPYHFGLTTQLLNEVDHGFNTGSMRGIYSPNVRCAQELVVDALAGKMGEDPLAFRRRHL
KDERARAVLDKVAEAGNWGRKMAPGTAQGIALHPEYHAFVAVLAEIDCRPETTGREIPDA
YTGPRVTKIVCAVDVGLAVNPRGLEAQMMGGIIDGIATTLTSSLHLKDGHFLEGSWDNYF
YSRQWNTPPELQIIVMPPTTGKPGGAGELAVGASMAAVACAYGRVTGTMPTTFPVNHGEP
LAFTPLPTTPPIPASPTDGRSRTR
>A0A839Z9H7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Angulomicrobium tetraedrale|TrEMBL
MKFTLNGTERTIDADGNMPLLWAIRDVVGLTGTKFGCGAALCGACTVHLDGAPVRSCQTF
LSDVEGKHVTTIEGVAGTGKVGEAVVAAWRKLDVVQCGYCQSGQIMSAVGLLSENRKPTD
DDIDAAMDGNVCRCATYQRIRAAIHEAASNLA
>A0A0S4X1R7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MTADATAPRRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQPGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVRVERAPIERIYGNVVSVVDSAL
PLHPDDAGKAWARALHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
RAWKVPAAQVSVHDGRLIGPGGRQAGFGEVAAHARDIAPPASVTLKPASQYRLVGQPAPR
SDAAGKTDGSARFAIDVRPPGLLYAAVAMCPVFGGRLKAFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQVVAKLEPVWDSGPHAALDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVGGATVVEAEYSVPYLAHAAMEPINCTAQVTRDHVQLWAPTQVATLAQLV
AARAAGVRSEQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIERGRVTALASRSAGQSILAGELGRLFGVPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEVAAAAGLDPLAMRRDLLEAHP
RERTVLDTAARAAGWGQPLAPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPGIVARQVESAVIFGLGAALHGQIQVKDGQVVQSNYSDYPVLGMADTPV
IETHLVPSAAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A173KX90|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium sp. EP60837|TrEMBL
MVMGRVPRKAANRRKQVGGVNRRTLLVGAGASAGLLLAWGLWPRTYRTNLNAAPGETVFN
AFLKVDRAGRIIVIVPQTETGQGVTTLLPQVLADELGADWRTVGVQSAPISPLYANSLLA
KEWLASDWSRLVGEAGEWAIDQYATRRALMLTGGGTSVPMFHDAYREAGAAARVLLCQAA
AARWDVPWESCDIDNGIISDGGQRTLKIGEVAAEAADFDLPEILPFRQGQADRLAGQDLP
RLDTPSKIDGSHNFAADIRLPDMLFASIRQGPIGDALLKSVNEQAAKSVTGFLKLVRTDR
WVAVVATNWWAANKALDLSDPVFELAGAPLSSASIDAALESAFSGSAGQRLYSQGDLKSL
FDNATILASEFSVAPGLHLALEPMCATARISDGVAEIWMPTQAPALARAAIADALGMTEH
EVTLYPLHAGGSFGRKMDFEAGVQAALVARDMGRPVQLLWSRLEDVVQDRPSAPAHARMA
AKLGRNGAIEGWLAKVAAPCAMTQTWDRIAHHKLPHEASRDSAGASTRLAVAGMELPYAL
PNWAVDHYPACAGLSLGFTRANAHLHGAFFTESFIDELAHQAGIEALSFRIQMLGGNPRL
AHCLTTVGAMGGWQGGIEGSGQGLAVHEMNGAYVAVMIEAALDGGMLSVGRIVAAVDGGE
QVNPDIARQQVESGLIYGLALAMGASVPYARGMPTRAILGRMGLPRLADIGEVTVELIRS
TAPPAGLSDIGAPPVSPAIANALFTVTGQRFRQLPILSRT
>A0A2C9D1A9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hartmannibacter diazotrophicus|TrEMBL
MLHYLQEPRAFRSSLPAASRRGFLKAMGGTTAGLVIGFAMPGIVSQVGEARAADMEAAFN
PFVQIAPDGTVTVLIKHLDKGQGIATGLVTLVAEELGASVGQMKAEFAPANVELYKNLFF
GIQGTGGSTSMANSFEQYRKAGAAAREMLKAAAAKDWSVPAGEVTIADGKLGHGDKSAGF
GDFAAAASKLEAPQDPPLKTPEEWVYIGKSFPRVDVPAKSEGGTGLYGLDVKRDDMLVVT
VIRPPKWGATVKDFDAAEALKVRGVVDVKSGPFGVAVFAKTTWPAIKARDLVKVTWDDSK
AETRGTDELLAEYRKAADMPAAVVKDADAEAALVAAAETVEMEFAFPFLAHAPMEPLNVT
ILADPGKSVEIWTGSQMQTVDQMVAGSILGVTPDKVTIDTRWAGGSFGRRAVYNSEYVAE
AALVAKAWGKVQPLKIVWTREDDIKGGYYRPMYVHKVRAGVDAEGMIMGWQHRIVGQSIF
TGTAMEKMVVKDGIDEASVEGIADTTYAINGFRLELASPKVGVPVLWWRSVGHTHTAYVM
ETVMDALAAKAGKDPVAFRLEHLKDDPRKVAVLKLAAEKAGWDTVPAKGRYRGVAVHKSF
NTYVAEVAEITYDAGNFKVEKVVCAVDCGVPVNPDNIKAQVEGGVGFGLGAVMRDAITLT
GGEVDQSNFDTYEPLRMSDMPEVEVHIIQSAEAPTGIGEPGVPPIGPAVANAIFKATGKH
PLKLPFTTGDFA
>H0SDE4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGAAVRSCGV
TVSEAQGKQITTIEGLAADNGLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSD
QDINDAITNICRCGTFAQVREAIHAAANA
>A0A089P0E3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium oryzae CBMB20|TrEMBL
MIKLTVNGAARSFDGDPDMPLLWYLRDELGLTGTKFGCGVSLCGACTIHLGGTATRACIT
PVSAAAGQEVVTIEGLSPDGNHPVQVAWRDQNVAQCGFCQCGQIMQAAALLKDTPKPSDQ
DIDDTMSGNICRCGTYPRIRAAIHQAAGQPAPATKGERL
>A0A7W8WIE5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WSM4180|TrEMBL
MELIVNGVHHNVDADANMPLLWAVRDLLGLRGTKFGCGVGACGACTVHLDGVAVRSCVTA
LADVQGKPVTTIEGLGKGGDHPVQRAWKAANVPQCGYCQPGQIMQAASLLKQTPKPSDEQ
IVEAMSGNVCRCGTYQRIKAAIKAAASEA
>A0A679IHQ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium bullatum|TrEMBL
MLKVRQTKSEAAAPRPSRRAFLGGAGVAAGALVIGFTLDPAKQVRAAAGPDLSSAPAQPN
AFVRIAADDTVTVLIKHLDMGQGNTTGLATILADELDADWSRVRVAFAPADAKLYNNLLM
GPIQGTGGSTAVANSWFQLRKAGAAARAMLVTAAAEKWSVPAPEITVSNGTVRHLASKRE
ERFGALAEAAAAIPVPEQPKLKDPSQWVHIGKKLPRLDSVAKTNGTAIYSMDIRRPGQVT
AVVAHAPRFGGTVSTVDDKAARAVRGVIDVVTIPTGVAVIAKDTWSAMKGRDALSVTWDE
RTAEKRSSDAILAEYRETAKRPGIVASEKGDPAAAIAGSAKVIEAEFTFPYLAHAAMEPL
NATIERAADGSYDIYAGLQFQTIEQAVAAATLGVTADKVRLHTQWAGGSFGRRATPTADY
IAEAASIVKATGGKAPVHLVWTREDDMAGGYYRPMVLHTLKAGIDVKGAITGWQHRMVGK
SIMIGSPFEAMLVKNGVDSTSIEGASDTPYALPAYRFEVHNAREGVPVLWWRSVGHTHTA
QAMEVFIDELAHAAGADPLAYRLGMLTGAPRLSGVLKLAAEKADWAKRSGGKGQGLGISA
HESFGSYVAMVADITADGSHVKVNRIVAAVDVGVAVNPDVIRAQVEGSVGFALSSVLRNK
ITLTDGVVQEKNFDAYEPTRMSEMPVVEVHIVASDAAPTGIGEPGVPVIAPAISNAIFAA
TGQRLRSLPLDLSGLKGV
>A0A679JU09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium bullatum|TrEMBL
MNDLTPSWPTAGRREPIRNLSRRNFLSAATGALVLGVNLGPDPVGAGERPEGAAAIAPKP
GTRVAAFLEMRPDGTVRLLSPFVEGGQGINTGLAQTIGEEFDLDPARFAVECAPPGPDYA
VVNGLRMTGGSFSTRSSYAAMRRLGATAREMMLRSAAAKLGVPQGQLATDDGRVIHAASG
RSLGYGELASAALALQPRDDVALKDPESFRWIGKPVARLDMRDKSTGRTVYAIDIRLDGM
LHAAIQHAPHLGTEPETIANEGDIRAMPGIDSVHRLPGAVAVVADSWWRARKGAEALQVT
WTSPARDGIATVSQSFSSAAMLAALKSTTEPGIAAEQDGDVTGAFASAAKVIEAEYDAPY
LAHAQLEPPSAIARFQADGSLDLWLPNQMPELFQQVAAGTAGVQPAQVRIHSPMLGGFFG
RHFYYGPANPFPQAILLAKATGRPVRVLWSREEEFGMDAVRPLSFARFRAALGSDGMPVA
LQTTAVGEGPIGRWFGALFKSPVDSSVVEGLDKKPYAIPNRRLDYVKVPHPVTIAFWRSV
GHSMNDFFYESFLDEIAAAGAKDPFALRMALLKDSPRHRTLLRAVADLAGGWKGGTFQAA
DGTRRARGVSMASPFGSETATIAEVSLKDGEARVHDLWIAIDPGSVVNPAIVKRQVEGAA
ALGLSSTLLEQVVYEDGQRQARNFDAYPILDRERMPRVHVAIVESGAPMGGIGEPGLPGV
PPAVVNAVAMLTGQRIRSLPLAKSRLSGA
>A0A1X6ZKM6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius albus|TrEMBL
MTISLNLNGKTHDVDAEPGTPLLWVIRDELKMTGTKFGCGVASCGACTVHVDGEPVRSCQ
TYIEDVGESEITTIEAMSDTEIGAAVQQAWVELDVVQCGYCQSGQIMSAVGLLTENPKPS
VEDIDNYMYGNACRCATYQRIRAGVQRASEILEA
>A4G4B9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Herminiimonas arsenicoxydans|TrEMBL
MPIEFQNLEFSNLNIFIYCWFATADTKDAILVICVSSPHSFLKIMANLNINGKQHQIDLS
DDTPLLWALRDHLGMTGTKFGCGMALCGACTVHLDGQPIRSCITPVSAAAGKRITTIEAM
GEDSVGKRVQQAWTELGVPQCGYCQSGQIMSATALLKTTPHPTDAEIDSAMSGNICRCGT
YTRIRAAIKQAAGKKG
>A0A375BBR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLEMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGSDRIGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A7Z7NNJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTRFQVNGQAKDVDVPGEMPLLWALRDELGMTGTKFGCGMALCGACTVHVDGTAIRACVT
PVSAVAGRSVATIEGMESDRVGQAVQQAWIQHNVAQCGYCQAGQIMTAVSLLKTTPAPTD
RQIDEAMRGNICRCGTYPRIRAAIRQAAGRLAQGGQ
>A0A375D1U2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLTLLQATGVLLVTRAPQPAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLAQVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAALQLGVDASALEAENGVFRVRGTQASLGYAALV
AGEHVELPLADDVPVKPVESYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLAIDRDSVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
KPVPPLPALDDPEPALRDNPATRRELLTEGELPAGGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELAMEAGADPVEFRLRHLPDERAADLLRAVADAAGWQCGAAGARGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDASTGRIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVLLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMAATKG
>A0A375J4X9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAARACI
TPVGSVARADITTIEGLSTDNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLKDNPSPRP
EDIRAGITNLCRCGTYPRIERAILRAATARSAGDPKGRASS
>S2DN18|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)|TrEMBL
MANYSLKINGETFNVDVEEDTPLLWVLRDHLGLVGTKYSCGIAQCGACTVHLNGEATFSC
TLPVSSVGSDEVTTIEGLSKEGDHPVQKAWNEVDVAQCGYCQAGQIMNAAALLKKNPSPS
MQEIEDTMNKNLCRCGTYHKIREAVALAAKNK
>A0A4V1EE35|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MVTLNINGRDTQVDADPSTPILWALRDNLNMTGTKFGCGAALCGACTVHLGGQPIRSCVT
PISAAVGQKITTIEAMEHDKVGKAVQDAWVKHDVPQCGYCQSGQVMSATALLKTNRKPSD
ADIDGAMAGNICRCGTYQRIRLAIKDAAKTLA
>A0A4P8HPN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MKLNINGKLHDIGADGDTPLLWVLRDELHMNGTKFGCGMSLCGACTVHIDGQPTRACVMP
AAAAIGKKITTIEAIGKQPVGLRVRKAWAALDVPQCGYCQSGQIMAAAALLRETPHPSDK
EIDEAMAGNICRCGTYQRIRLAIHKAARDA
>A0A841HQ72|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MKRIRHAGHAKDTPMNPVADEERSASTLTRRGFMKLSLSASGGLLLSHFISTEAVATATP
GGHAIGTLVRIEPDGSIVIGSRAPEIGQGVKTSLPMILADEMDADWARVRVEQLPLGILK
KDDGTFTWKYGPQGAGGSTSIPDAWGDLRQAGAQVRHVLLQAAAVRWQTDATGLRTSSGF
VIHPDGRRLGYGEVAAEAAALPLATESLKLKDSREYSIIGTRQRVVDAGDIVTGRAQYGI
DANLPGALVAVVARCPTFDGELVSFDATQAKKIPGVRDVVVLAGPKQGQPITANLAAGVA
VLADNTWAALRGREALKIEWTPGPFAGESSAALDAQCTKLLEGEGRRVRNDGDFDAARKS
ASRVIQAIYRVPFVSHCPMEPQNACADVRRDSVLIIAPMQMPGGASRVASQITGIDRSKI
EVRMTRVGGGFGRRLSNDFVAEAVQLSKTTGRPIKLLWTRDDDLRHDFYRPFGHHQVIAT
LDDRGDVSGWAHRLASASKYYRRADVKPEDMWTAELYPDDFPARLVPNLRMEWFEVQSGI
TRGSWRAPAHTANAFVVQSFLDEIASATKKDPLALRLALLGEPKDLPYEQHGGPVFNPGR
LATVLKRAAERIGWGSAMPPGSGLGIAGHFTFGGYAAHAMQVRVAKDGSYRIDRCVCAVD
VGRPINRLGLEAQMQGGTIDGISTARQLEITIEAGRVKQSNFNDYPLLRIADAPAVEVEI
IDSDRDPSGAGEMGIPTAAPALTNALFAATGRRIRSLPIGVRV
>W2UF67|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gammaproteobacteria bacterium MOLA455|TrEMBL
MKKASMTRRLFLLSTGAAATGLIVGCSTAAAKGGGYSSIAGAFEPNSFIQITPDNQVIFY
LPSSEMGQGILDGLTTLIAEELRVQPGAIDVRHASLHEDYKNPEMGMQATGGSNATRAQF
LPLRQAAADTAAAIRNAAAKQLDQPLDKIALADGQVIVEDKSYGFGDFVAVAALMPVPEN
SPLRSPKQFDQIGRERPRLDALSKSTGSAEFGIDAEVENLYRAVVVRSPVLGATLLGFDA
SAALKRSGVVDVVQIKSGVAVVAQSYWQARQAAAALELNWEKTELASWSSDSIYNKFNET
LNDSSQKGLECCDEGEGDKLLDQSATVVAADYYAPYLAHATMEPLNCTVEINGDACAIYL
GTQNIQASAGAAVYYGDFDADKVKVHPAFLGGGFGRRGLGDDVAEAVLIAQQTGRNIQLV
WSREDDMSNDFYRPAALVRMQAGVSEQGLIETWAVRRVGPNIMGYMLDEWVDALAPDYLN
KRFVDWLSKLGRPIFNRFIADPSAGDGIYSDYDTPNKAVRHVTQDPGLRTGFWRSVGHSS
NAFFKESFIDELAQSAGIDELQFRLANMKNNPRLTEATQLVAAKAGWGKPLPEGHFHGLA
THSSFGSAVAEIAEVSIEGTQIIVHKVTAAIHCGMVVNPGIVRDQIEGGIVYGLTAALHG
EITLVDGVIQQSNFHDYPILRMADAPEVEVHIVASQEHPEGVGEPGLPPLAPAVANAVFK
ASGQRLRDLPLRLS
>A0A7W5QQT9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. BK369|TrEMBL
MLIGAGAGGALIAAFALVPRHYAAPLVAGKGERVANAFLKLARDGTLTVAVPACEMGQGV
TTLLAQIVAVELGADWAQVAVEPAPLSPAYADAVLAAHWAPLWLPTWLPILPDMMADPAN
GLTRLKAERGPMMLTVAGTGLAMFEQPLREAAAALRAQLIAAAAAQWGVAADSLDTRGHA
VIERRADQQGRRLPFARLIDAALDRDPPHDVPLRASPAQEAPARFPAGSRPAFPRLDLPA
KVDGSFVFAADVRLPGMVHAAIAHGPQGGCVLSSWDAQAAARVPGCLGVVHAKGWLAAIG
VTWHAADRAVAAMEPRFRPRGPVADSNAIDAALDQGLAKGKPVRLWGQGDPTALLEKPSL
SARYDIEVALHAPLEPATCTARLEHGRLELWLVTQAPEAARREGARAAGLSEADVVVYPM
AAGGSFDTRLDGRIAGEAAALARATGKPVQLTWSRWQESLAGLPRAPVAGLLEAGMSPDK
QQLLGWRSRIATPASLRETAARVLDGEGAQSARRWQDSADPLALEGAMPPYAIPECAVQH
VPVALPLATARMRGGGAAITAFLTESFIDECAHFGGSEPLAFRMAMLGGQPRLAACLQGV
AHLAMWGGGADASGQGIACHALTLAAPEGPRHGYIAVVATARQVDGAIRVEALSACVDIG
RVINTDLARQQIEGGLFFGLGLAVGGSTGYAAGRPLAGHFSQLGLPLLADCPKVEIVFVE
SSAQPFDPGELGVVAVAPAIANALFSATGLRLRRLPLLSEGV
>A0A379A034|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pannonibacter phragmitetus|TrEMBL
MPVTLILNGKEQVIDADPDTPLLWVLRDTLGLTGTKFGCGVAQCGACTVHLDGTPVRSCQ
TYLSDVEGTSITTIEGLESPAAKAIQAAWTELDVPQCGYCQSGQIMAATALLMETPKPTG
ADIEAAMDGNVCRCATYARIKTAIHAAADKLEG
>A0A388RYS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MHLDGTPVRSCITPISAVEGKTIWTIEGLGQAEIGAALQAAWIALGVPQCGYCQCGQLMS
AAALLAEHPRPSDEQIDQAMSGNLCRCGTYSRIHAAIKRAAAALRGKA
>A0A0N7M8E3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria denitrificans|TrEMBL
MASVGKILRRTFLIGSAAIVGGVAFGAYYVSRPAANPLKPGEGQAALNPFVLIDQNGVTL
FAPRAEMGQGVKTTWAALIAEELDVGLDQITVLHGPAAAAYYNSAMLGEGLPNKGYDISD
FQHNLGEALGVLGKALHLQVTGGSTSMKDGFERMRQAGASARETLKRAAALRLGVEPSEL
GTASGHVIAPNGDKFAYSDLAVDAAGLEPVEVPLRDPSKWRYLGQTQPRLDMVEKVTGTA
EFGVDVRLPGMKFAAVRMNPKLGGAMHGYDDSTAQSMPGVEKIVDLGTGVAVIANNTWLA
NQAVEAIDVDWGDAPYPPETDGIFAKIAEAFDDSANSTMRDVGDVSVTPDGATEITAEYQ
VPYLAHATMEPMNATALYTGDALELWCGNQAPTLIRFRAANTANLDTEAVQIHTTYLGGG
FGRRGELDFSEIATKVAMAMPGTPVQTTWSREEDMRHDYYRPGAIARMRGAVQDGKAVLV
DGKVAAQSCTQQAVTRYTGMPGAGPDKVLVEGFFNQPYAVPNYRMSGHIAKLDVPVGFWR
SVGNSHNGFFHETFMDEMAHAAGHDPLEFRLELMKSEHAPSAGCLEAVREMSGWTGQTPD
GFGRGVAFTYSFGTPVAQVIEVVDEGGTIRINKAWIACDMGLALDPENVKAQMFGGMMYG
LSAACYGEITFAEGEVEQYNFPDYDAIRMHSAPQVEVRVLETNRHMGGAGEPGTPPSMPA
LGNALFDLTGERARKLPLNQQFDLLI
>A0A1N7RNZ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia piptadeniae|TrEMBL
MLKLNINGKTVDVYSDPTTPLLWVLRCELKMTGTKFGCGVGVCGACTVLVGKEAKTSCQE
KLSDIGANDVTTIEGLHGPQARALKEAWTRIDVVQCGYCQSAQLMAASALILNNPHPNTK
DIDCAMHGIICRCGTYPRIRQAILEATGQVRSNASPCEKG
>A0A7Y7LP92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MNQADAPGAVSRRGFLKVAAAAGGALMVGFWPGEGEAAAGAPAGLNAYIAIGADDSIVLT
MPKVEMGQGTYTSIPMLIAEELEVDMDKIQLRHAPPDAKVYGAPFGDQFTGGSLTIRTLY
EPMRQTGAAARMVLLQAAANQWSVAADSCRAEHGAVLHAASGRRLKYGQLAAAAAKLPAP
HQVALKDARDFKLVGKPLKRLDARGKTDGTAQFGIDAQVKGMKVAAVAACPVIGGKLKSV
DDAKARKLRGVRQVVRLDNAVAVVADNYWYARQGMAALEIVWDEGPNARLSTDDVRDTMV
LALRKAGHVARNDGDAMGVLMAAGQRIEALYLNPMLAHATMEPMNCTVHVKGDGTAEIWT
GSQVPARARDEAARVLGLAPDKVTLHNHLLGGGFGRRLYTDYVVQAAAIAKQVKAPVKLV
WSREDDIQHGPLRGLYAHSVWALLGADGKPVALSHKIAGPSNLAAFAPGWLKDGLDTDNV
EGSDNFSYDIPHLRSEYVQEDGPVPTAFWRGVGPTRNMTVLEGFMDELAVLARQDPLAYR
LSLLEQQPRAAQVLQVAARKAGWGEPLPPRHGRGIALMRAWGTYLAQVVEVAVGDDGEVA
VKRVVCAVDCGQVVNPDTVVAQIQSGINYGLTAGLFGAITLKDGRVEQSNFHDYPILRIN
QTPRIEVELIASGEAPGGIGEPGTAGVGAALTNAVYAATGVRVRELPLRAELLKKA
>A0A7W6UFB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium esperanzae|TrEMBL
MTAFTINGRAVDVAAEPDTPLLWVIREHLKLTGTKFGCGVAQCGACTVHVDGAPTRSCVT
MLQDVSGRAVVTIEGLSPDSDHPLQRAWIAEQVPQCGYCQSGQIMQAAALLQSTPKPTRE
QIIEHMDGNICRCGTYGRIISAIERAAQEA
>A0A238JF91|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas phthalicica|TrEMBL
MKFTVNGTEHEVSVEDDMPLLWVLRDELNITGPKYGCGIAQCGACTVMLDGQAVRSCQVT
ADELEGTEVTTIEGLGTPDALHAVQAAWVEHQVAQCGYCQSGQIMQAAALLDMNDDPSDE
DIDQVMSGNLCRCGTYPRIRAAVKTAAKTLQEA
>B6BB52|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacterales bacterium Y4I|TrEMBL
MSTTLRINGKPHQVDLPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVHIDGAAVRSCQ
VALSDVWGEVTTIEGLGTLEAMAAIQQAWVEHQVAQCGYCQSGQIMQAASLLAENPSPSD
AEIDEAMQGNLCRCGTYPRIRAAIHAAAQKTQEA
>A0A509EKW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MIKLTVNGAPRSFDGDPDMPLLWYLRDELGLTGSKFGCGAALCGACTIHLGGTAARACVT
PVSAAEGQDVVTIEGLSPDGNHPVQAAWRDLNVAQCGYCQCGQIMQAAALLKDTPKPSDD
QIDEAMSGNICRCGTYPRIRAAIHQAAGQTPAAKGERL
>A0A1V1W4Q1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides sp. PD653|TrEMBL
MPRQTFVLNGKPTTVDVHDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHVNGRAFNPC
SVRVGDLEKTDEITTIEGLADTVDGDLHPMQQAWLDRDVAQCGYCQPGQIMAAVALVRKV
RREGRSITDADLDGIRNICRCGTYTRIREAIAQGERQM
>A0A7W6DZS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Croceicoccus naphthovorans|TrEMBL
MKLSRRKLLVGAAAGGGLIAAYALLPRDYPVPLPAGEGENAFNAWIKIARTGVVTVAVPQ
LEMGQGATTIIPRIAAEELGADWRQVAVEPAAISPAYADPVLAAHWAGLRGTWLPSFADD
PDDFLAKNFASQTRLMATAAGTGIAAYEMAIREAAAGVRAVLAMAAAERWGVAFEECEAQ
AGFIVHGEKELRFGELADDAALLSPPSPAVLRPDPPSDNMPDLVDGAAVYPRLDGPSKVD
GSFRFAGDIRLPEMVHAAIAHGPLASATLSGFNETAARTVTGYIARVEGKGWLAAIGSSR
WAAEKALERMKPQFKAGRELPDSAAIMAALDNALENGEPEVLSEVGQSDVALEGLGVYEA
RYTMAPALHGTIETTSATARFTDGRLELWMAAQAPEQAREEAAAAVGLTPDKVVLYPVGA
GGSFDARLDHRIAREVAAITKAIKRPVQLSYSRRQEHLTALPRPPMVAKVRGIIGPNGTI
HAWHARTAAQAGAREMFARLFDGQTPEEAHDAAAGLIDPANLSGMAPPYAIPNLKIESVS
AETNLPAGRMRGNAEARACFVTESFLDEMARQAGEEPLGWRIAMLGNNPRLFECLQGVAQ
LGEWDGGSDGSAQGLACWQMPDPAGQEGGGGTIAVIVRARPGENGVDVSSISAWCDIGRI
VHYDIAAQQIEGGLIFGLNAALGLGVTYDSGMPRERTLADLRLNPLGRTPEISVGFAQSD
APPFDPGELGMVAVAPALCNALRSATGNRFRDLPIPVGQVTLAPAPVAETPATPTDGESE
AAVPEPEPSVLPDGSVAED
>A0A840GAD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR18|TrEMBL
MIKVKINGQEQSWDGDPDLPLLWFLRDEAGLTGTKYGCGQALCGACTVIVDKQAVRACIT
SVNDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLMDNPKPSHD
QIRESMSGNICRCGCYQRIENAVHLASTGV
>G3A8M1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia syzygii R24|TrEMBL
MVTLNINGKPVEVDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAVVGAQITTSEHIADDEVGKAVLNAWVQHDVAQCGYCQSGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAAKALA
>A0A7W6WCS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium mongolense|TrEMBL
MAQLTINGVARDIEVDPETPLLWVLREQAGLTGTKFGCGIAQCGACTVHIDGVATRSCAM
PVSAIDANQQIVTIEGLSPDGSHPVQQAWLALDVPQCGYCQAGMIMAATALLNTTPDPTD
DDINAEITNICRCGTYNRVRAAIKLAAANSSAAQKG
>A0A7W6RT13|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium mongolense|TrEMBL
MSYDLSVNGKNYAVDVDGDIPLLWVLRDTIGLTGTKFGCGIAMCGACTVHVDGVPVRSCV
MPVAEAAAKPITTIEAIGETDEGARVQKAWLDIDVVQCGYCQSGQIMSATALLAANPSPT
DDDIDAVMAGNICRCGTYPRIRAAIKLAAKAR
>A0A840GQ18|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR18|TrEMBL
MNAHDSVSRRALLTGGLATGFLLAFHLPLRAAANEPAQPRDATEGKFAPNAFIRIDETGR
TVLMMPQVEMGQGTYTSISAVLAEELDADWSRVEVQHAPPNDKLYGNPTFGLQVTGNSNS
IRAWWLPLRKAGATARAMLVQVAAAQWGVEPASCTASKGEVAHEASGRKLAYGALALAAQ
GQTPPKDVALKDPKDFVIIGQPLKRLDTPDKVNGKAVYGIDAILPGMKFATVAACPVFGG
KVGKVDDSAAVKLPGVRKVVVLDDMVAVIGDHMWAAKKGLEALKIEWNEGPNAAITTKDV
WDDLRKASQKDGAVAKSDGDIAKALASGDKFEATYELPFLAHASMEPINATVHVKPDSCE
IWTGTQIMTRVQSEAAKAAGLPVDKVIVNNHLLGGGFGRKLEPDMVVAAVKIAKQVDYPV
KVVWTREEDIQHDVYRPVFRDQITASLVDGKVAGWKYKVAGSAVLARWLPPAFQKGIDID
AIDAAVDAPYDFANFHVEYVRAEPLSVPTGFWRGVGPNNNVFAVECAMDELARKAGKDPI
EFRKSMLTKNPRILAVLNQVAEKSDWGQPLPARVGRGVCVQPSFASFIATVVEAEIDDIG
EIVLRRITSVVDTGIAVNPDTVKAQIEGGLIFGLTAALYGEITIDKGRVQQSNFHDYRMM
RINETPKIEVIVVKSGEAPGGIGEAGVNAGPPALRNAILAATGVALRRLPIDRKLLAAGK
KA
>A5EDG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MNQHVKAAPSMAPDLSRRSFLVGTAATGLVLGYAGLADSALAATTPASFEPSVWYSIAPD
GLVTVTCGKADMGQHIASTMAQIICEELGAAWKDMRVQLASNDPKFNDPVLGAQITGGSW
STMMNFDAMSRAGAAGRIALTEAAASAMGVPAKELVVRDGVVMHPKSKKQMSYAEIVKSG
KITKSFTADELKALTLKTPDQYTMIGVSVPQLDIPAKTNGTAKYGIDTMLPGMVYGKVVT
PPVRFGATVKSVDDSEAKKVPGFIKAVVLDDKTGSTSGWVVAVASTFANAKKAADALKIS
YDKGPYANVSTDSIITEAMRLQAQDDAGQFFVKDGDANAALAGAAKVLEAEYTTSINIHA
PMEPMNATAEFKGDILHIYSGNQFATRSGAIAAGAAGIDPKYVVMHQAWLGGGFGRRLDA
DMMVPAVQAAKAVGKPVKVIYSRENDMTMDYSRPLTYQKVKAGLDSNGKLIALSHDVVSA
WPTARWGIPDFLTPSVDKKGPLDSFTVNGADFFYTVPNHHVRAIKNELAHNATPSGQLRS
VAPGWTFWAVESMIDEIAAASGQDPAQFRIALLDGKGKNDGGAQRLRNTLLAAMGLSGYG
SKKLSKGEGMGVACVSSQERASASWTACVAHVAVADNGAVTVKKLTVATDVGTQVHPDNI
RAQVEGAALWGLSLAMYEKATLKDGGIEQTNFDSYTPLRMSQVPEVAIAVIANGEKATGV
GEPAVTVVAPALGNAIYNACGARLRSLPITAEAVKANMKA
>A0A087PRP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MSPVFVHNANNALGAVSRRHFLAGGGLLLAFAQAPRVHAEAASSALSDSLKPNTPTTLGG
LVKIGTDNQISLIVPNIEMGQGIYTTEAMMIAEELEVALEAITVLTALPQEVSDISPAFL
KSLSTGGSKSVRKGWIPLRQAGASARLMLLAAAAEKWNLPQQSLYAENGIISDVSGRYHA
PYGDFALDAARQHVPEHIPLKPPTEWKLIGHSCPRVDIPAKVTGKAVFGIDVRLPGMVFA
AVMGPPVLGASVDSLDTNITKAIPDVLDVLHNDGMIAVVAKNYWTARKGLDALKIKWNQG
PNATLSSEDIRNIIRDAAHFIPAVVARDDAGTDVALKSGKNIEQEYQLPFLAHAPMEPAN
TTLHVRADGCDVWMGTQVPTRARKAVAKITGLPEEKIAIHNYMIGGSFGRRLATDFLEQA
TKFACKISAPVKFIWSREEDIRQDLFRPAYYDRMRASLDADGLPLAWCHHVSGPSVVDRF
APGGLPAGKLDSDAVEGAVQTPYELPLMRVIWTRVQTPVPVSWWRGVGPAHNVYVVESFM
DELAAEAHTDPIEYRLRLLQKNPRSVAVLKRVRQESQWGTALPARTGRGVALHNAFGTHC
AVVVEVAVPQGGPIMIKRVTAVVDCGIAINQDALIAQMEGGLLFGFTAALYGEITIKNGQ
VEQTNFHNHRLMRINETPLIDVHIINSGEEPGGIGEVGTTSAFPALGNALHNATGKRFRS
YPFNQIDL
>R7ZT01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lunatimonas lonarensis|TrEMBL
MSIQLKTNRRDFLKIAATAGGGLLLGFHFSGCDSPKISVVSDEELLAQAVNYNAFLSIAP
DGHVVIYSPNPELGQNIKTSFPMIVAEELDADWEKVRVMQAFLDNEKYDRQVTGGSGAMP
HSWERLRKAGATARRMLIEAAAKRLNVDAGSLSTDKGMVIHAGSGKKLGYGELAKEAASI
EVPEDVPLKNIKDFKIIGTPVKNVDNKAMFTGKPLYGLDIYRDGMKHAMVQRPPFGMKLK
SFDADAAKGVNGITDVVTFNDNVAVVGNSTWPLMKARKLLNIQYEPIDGELESTEMHNRI
FDDLLNNGKAQVMRKDGDVNAAFRNAAKIVKSEYQCPFLSHSPMEPMNFFAHVRPDGVEL
VGPTQTPDRAKAAAAEIAGVDPDKVTVEMTRLGGGFGRRLRADFVEEAVHVSKLVNAPVK
LIWTREDDNTGGAYRPAVKYRFEAALDANNTFIGYKLKGVGLNAGNTTRENNFPSGSVDH
LLIESIDYKSHITTNAWRAPITNFLAFAEQSFLDEVAEAAGKDPVQFRLELLDRAKKNPV
GSIHYDVDRMRGVVEMAAEKSGWGKKQGVAQGFSVYFSHRSYVAQVAEVRMNQGNPVLEK
IYAVTDCGIVVNPTGADQQVRGGMVDGMGHAMYTNMTIKNGLAEQKNFDSYRLIRMKEIP
EIETHFVDNGIDPTGLGEPALPPTGGAISNAIYWATGKRLRNQPFIEQEELKEFNLGQRS
>A0A840RSW6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Glaciimonas immobilis|TrEMBL
MKSIDRAFQTAASQFTSPDVPSHFPITNVSRRRFMQTSGGLVLGLQLGSLMAATGTGAAF
EPNAFVQISADGSITILAKHLEMGQGVYTGLATLIAEELDADWRHVRAEGAPADTKLYQN
TGWGIQGTGGSSSIANSYEQMRKAGATARAMLVSAAAAKWNVAPESITITKSVVHHAASR
RAAGFGELAAAAATQPVPTDVKLKSPKDFKLVGNPTLPRLDSPTKTDGTAMFTQDMKLPG
MLVAVPLHPVRFGATVKTVNAVKAKAIPGVVAVVQFAGTPRSFAGVAVLATNTWAARQGR
NALEVEWDETHAYKKGSPEILAQYRAALKKPGMIAKKVGNVDTALVKPAILIEADYEVPF
LAHAAMEPLNCLVQLGETTCEIWNGEQFQTIDQGSVAKFLNLPAEKIKINQLYAGGSFGR
RANPHSDYLLEAVSIAKSAREQGVRVPVKMVWMREDDTRGGYYRPINVHRARLALDAQGR
LSAWHVRMAGQSIMEGSAFAGVIKDGIDPTSVEGQADLPYNIPNLQVELYTPQDVGVPIQ
WFRSVGHTHSAFSSEGLMDEAAIAAGKDPLAFRLSMLTSHPRHSGVLQLAARQAGWSKPL
APGAKGERRGRGLAVHESFNTFVAQVAEITVKANGTFKVDRIVCAVDCGVAVNPDVIKAQ
MEGGIGFGLAAALHGAITLKDGVVEQSNFHDYQVLRINEMPKIEVFIVTSTEKSTGVGEP
GVPPVAPAVVNAIFSAMGKRLRTLPIGNQLTQKA
>K1M0H2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MATFNLNINGKTQIVDVDPNTPILWVLRDHLDLVGTKYGCGIAQCGSCTVIMDGNAVRSC
SIPVSAAEGTKITTIEGLSEKGDHPVQKAWMEHDVPQCGYCQAGQIMSAVALLDNNPNPS
DTDIDNAMNGNICRCGTYVRIKKAIKTAANS
>A0A0R2Z6Y1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MTETTLSREQWLAKAGVLLIVDDVLPPSGPVAKGGTPTVKPKELGLFIAVNDDGLVYAFN
GHVDLGTGVRTALAQIVAEELDLGMDQVRMVLGDTARAPNQGATIASATLQISAVPLRNA
AAEARRFLLARAAGRWGVSTASLKVEAGVIHAADGRTTTYSELVSGQHDQVRISGNAPLK
APADYRLVGQDTTRLDIPGKATGELTYVHDMRVPGMLHGRVVRPPYAGLDCGEFVGNSLL
SVNEASIAHIPGIVAVVVIRDFVGVVALREEQAIKAAAELQVQWKSWAHAAPDMRDVAQA
IRANPRVRRTVLDQGEVDAALANASQRMPRTYLWPYQMHASIGPSCAVADYQDNGSRVWS
GSQNPHLLRADLAWLLECDEALIEVIRMEASGCYGRNCADDVCADALLLSRAVGKPVRVQ
LTREQEHLWEPKGTAQLMEVNGGVNADGSIAAYDFETSYPSNGAPTLALLLTGRVEPVAA
MFEMGDRTSIPPYDIDNMRVTINDMAPIVRASWMRGVSALPNTFAHESYIDELAFAAGVD
PVEYRLRYLKDPRAIDLVKSTAERAAWSPRTAPMQTASDDHLLRGRGFAYARYIHSKFPG
FGAAWAAWVADVAIDKHTGDVSVTRVVIGHDAGMMINPAGVEHQIHGNVIQSTSRVLKER
VTFEESTVASKEWGGYPILTFPEVPKIDVLMMPRQDQPPMGAGESASVPSAAAIANAIYD
ATGIRFRELPITPERVLAALNAGTLAEPAKSPQKRRKWWFGALFATLGALLATAWPFHSE
IAPIAPPSPGTWSKATLERGRLLAAVGDCAVCHTAPGGAPNAGGLAMQTPFGTLYSSNIT
PDVNTGIGAWSYPAFERAMRDGIGRDGRNLYPAFPYTAFRNINEADMQALYAYLMSQAPV
SQAPKPNAMKFPFNVRPLMAGWNALNLRRGEITPQPERSEQWNRGNYLVNGLGHCAACHS
PRNLMGAQKGGKAFLAGGVVDGWEAPALTGLSKAPTPWTEDQLFSYLSTGYSDAHGVAGG
PMGPVVSELSKLPKADIRAMAVYLASLNHEAAAQAQVAAAGIPNPNGRRVFEGSCKACHA
DGLGPKLFGVSPSLATNTNVFSDQPDNLIKVILQGISQPATRDLGYMPGFRDSLSNTQVA
DLVAYLRGRFAPNAPQWQGLEQKVAHLRADPGSH
>A0A3G8CFV9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R4-34-07|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGAVKGQAISTIDNLHTDPVGQVVQQAWLDTAVAQCGYCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQAATHLGAKA
>A0A3G7U833|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MELRINQKAYQVDAEADTPLLWVIRDNLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAIETDEVGKRVVATWVERQVAQCGYCQSGQVMAATALLKHTPAPTAE
QINAAMINLCRCGTYNAIQSAMQDLAKRESV
>A0A7X5V977|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kribbella shirazensis|TrEMBL
MVERSTAEHTDGRGLLGRRRVLGYLIAAPTLAVGVSWFANESGPRAADAAVPSLPQPENI
FDLGDLQNLAAAPTSGLITVEIKADGTAYFAVPRCEVGQGITTAFAMMVAEELDLPMNKV
EIALADARPELLMNQLTGGSNSMRSMYLPVRTAAAIARQRLVETAAARWDAGAEQLTTRK
GVVSGPGGRTATYGSLAEAAASATTIAVSAQLKDPSEFKVLGQPRTRVDAFDSVTGRKQF
AMDLQVPNAKPTMVARPPTINGTLRSINNLAALRAMPGVTDVVGITHGVAIRAETFGQCI
DAIQKVDATWGPGTVDDESDATVLAKLRAAQLPMAVPPLLSKTIDAEFVFAFASNSPLEP
DCAIADVRPDSAEIWSCLKVPILAQEDIAKQLGLPIDAVKVHVVQGGGSFGRHLFHDVAA
EAAEISQKMGKPVKLSWSRTDNFRQGRTHPMCTSRVRVNYLGGNVLSYEQRHTSVETDFG
HGLGEMITAFAADLPVAGNLSFAQTIFALTQTSPYNFGVTTQLLNEIPLKFNTGSMRNIY
SPNVVCAEELMVDQLAAKMGQDPVRFRRNFLKDQRLLAVLNKAAEVGNWGRTMPKGTAQG
VGVHSEYRAAVATLVEIDCRPETVNRPVEGEGVTGPRVTKAVIVVDPGFCVNPRGLEAQM
IGGLQDAIALALTSSLHIKDGIPLEGSWDNYFYTREWNSPLDVEVVIMPNTSESPSGAGE
LAVAPAFAAVACAYARATGTMPTYFPINHGKLGFEPLPLQPSTPQSPTDGLDHTF
>A0A0A0HLV3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus DSM 17069|TrEMBL
MGRARTITRRSFLIGSAAIVGGVAFGAYYVTRPTPNPLLNDLPEGEAALTPFVKITPQGI
TLIVPRADVGQGIASTQAMLIAEELDIDPATATLDPGQPHPAYFNGIIAAESMPFPAWEH
GVVADTVRDVMMNVARLTGSQFTGGSSSVADLHEPLRLAGATARETLKAAASARTGVGRA
DLRTEEGHVILPDGTRIAYTDLAAEAAAIEPVTDVTLRPASDWMRLGKPYQRLDIVAKST
GTQDYGIDVVLPGMLYATVRANPGRGGAMASYSADAALAMQGVRSVVEVNEGLAVIADNT
WFAFQAAQALEVNWLPPDYPASSAEMWQALTAGHTDEFRNSRLRDDGDVEAALGGATVIE
AEYRTPLLAHAALEPLCATVLIEPDRVQIWTATQIPAVVRDAAAELTGLNPSQVTLHALP
AGGSFGRRLDNDYVVQAIQIAATMPGTPIKTTWSRKEDMTHDYPRPLHMAVGRGAVRHGQ
VMAYDLDTISPSLIASWFGRIFIVPPGPDTMLVWGAYDQPYAIPNYRVTGYAAPPMMPVG
SWRSPGACSNSFFHESFLSELIHAAGADPLEERLRLIADADSRRVLEAVGEMSEWAGADI
GPGRGRGIAFAHTHGVPVAEVIDVTLTDRGIRIDDVWIAADCGTVFDPVNAEAQLTGAAI
FGLGHAMNCELTYESHAVQQTNFDAFEGMRLYQTPRFHTQLLGLAERVRGLGEPATAPSA
PALADAIFAATGQRLREMPFNKSVDFT
>A0A0A0HML2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus DSM 17069|TrEMBL
MLVEAAARLWSVPAGEITVTAGVVRHAASGMSSGFGAIAERAAGLEMPQNVTLKDPADFT
LIGAEGITRLDAVEKARGLATFTIDVMRDEMQVVAVLHPPKFGAKVASFDPVEALDVSGV
LAVREIPSGIAVYAVDTYSALRGREALVAAWDESAAETRSSEEIEAEFIAAARAPATVSE
ETGDVEAALSESAQTFEAEYVFPYLAHAAMEPLDGVVEWTPERAEIWSAIQIPTVAGPVF
SAALGVAEDAVSVHTMYAGGSFGRRATASGQFEAELAAVAAAGGPGAYKLQWTREDDMTQ
GYYRPLTVHRLRAGLDTDGNITGWDNTIVNQSIAFGTIFEQTVMNDGVDRMAVEGSVDLP
YGLPRRRVSWAQMINPVPVLWWRAVGHTHTAYATETFLDELLAAAGRDAVQGRLELITPD
RARDRAVLERVADMAAWSGPGNGDRRLGVALHKSFGSYVAQIAEVENRDGAPHVTRVWCA
VDCGVAVTPDIIRAQIEGGIGFGLSAALYEQLTLEPGGTVRERNYDSYRVLGLEDMPQII
VDIRPSTDIPTGVGEIGTPPIAPAVANAWRSFTGETPRRLPMIRA
>A0A7X0ANM1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. A1T4|TrEMBL
MSDDLLSDHVSNRGIRLSRRRFLQVLAGGAGALMIGIRMADAADVDVPLPPSLLGDTFYG
IGAYVRIDTDGNVLIGVRDPDTGTGVATSLPRIIADELDADWNRVSVVSLGLGVTNNNGE
PSWIYGRQVGGTGGSISAAWADLRQAGAVARWLLLQAAARRLGVPADRLRCESGTVIALD
GRRFTYGSLIEDASKIDMPNSVPPLKTAERYQLIGNPAGDVDAREIVTGQTRFAIDQQYG
DTLTAVVVHCPWPDGTLDGIDFTDTLAVKGVVKVLQLNPEAGQQTGTTLSTIAVAVVAED
TWSALKGRQKLKLKWKPGASNSESSDALEQQAVALLAGKTDPTTRVRNDGDVDAAGKKAA
RRLEATYFQPWLAHATAEPMNCLVRVEKDKATLVVPTQAPQKAWAVVHRLTGLTPDQIQI
SVPRVGGGYGRRLDHDYVAEAVMLATNKDINKSVRLMWTHEQDLDHDYYRSGSVHQLSVV
IDHKRQITGWNQRMASASTLVNRGVPDSRLWTSEVDVDQLPAALVSNYRSDWYGQTSAIP
RGPARSMPHLSNAFAVESFIDEIAHSMKEDPLDTHLRLLGEAREVPLSGGGTFDTGRLIN
VLKLVADRIEWKNWLHSVNGLGIACWHFNGAYVAHAIEVASKDQKLVIQRVVCAVDVGRI
INPMGLEGQVAGATLDALSTALNLSITFKDGQIQQRSGKDYPLASMAQLPDAVEVITVSG
DRDPAGASFLAMPTAAPALANAVFRATAVRIRRLPLTKELSRLS
>A0A3B0S929|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MIKNRIPLKNNSSVKASRRKFLKQSAGFTFMIGASGLISACGTNGPNKASASSRSDPMQA
NIWVTINPDDTIIVKYAGTEMGQGSMTHVPMMLAEYLDADWDKVTVEIVTIHDTAYGNPI
FQNMLYTAGSTHVMVYSKKMKVAGTQARKLLMAAVAKHWDVPLSELGTDIGNVIHKSSGR
RISYGNIVADVDLSSDIPDINDSDFIPEAKFRYIGKQVMRRDVPAKVNGKAQYGMDVQVP
GMLYAAILRTPVEGERPLKVDDILARGTRGVTDIVILPYGVAVVAGTVEATKKGKRRLKV
TWSEDSPFRQASTKASIAEYSSAAKDLNKTGIAWFSKGDSKGAIDKAENVLSAIYTSDPL
YHAQMEPLNATASVSDDGKSAEIWVGTQTQSLTIIGAAETLQTTNDKITLHPLTMGGGFG
RRSLLHQEYVDDALYQRPF
>A0A160TPW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MMAVSDALPNINRRSLLIGGGVGVGLFVAWGVWPRSYAPNLTAAKGETVFGAWLKIGLDG
HVTVAVAQAEHGQGVYTTLPQILADELGADWRTVAVQPAPLNPLYANPMAADVLFDGVFD
ALPAPLRSGHASRTALVLTGGSTSVRAFEDDLRDAGAAARVLLCKAAAKRWKVDWQACGT
AGGFVIHGTDRVRFGEIAAEAAGGTLPNPLPLRSGEANRLLGQSLPRLDVPSKVDGSANF
AGDVRLPDMVFAAIRQGPVGDTKLISVDRAAAGRIRGVLSVATNDNWVAAIGSNWWAANQ
ALAAMRPRFQTRGAIISSSSIDDVLTAALDGPGERMAAEGDLSAAFKGARLVTAEYSAGL
AVHAAVETMTATAHYADGRLQLWLPTQAPGLARAAAAAVLGMSEDNVVVYPMLIGGSFGA
NLEHLAAEQVAILAEKLKRPVQLVWSRSEDMMHDRYRPPAAARMSARLGPNGQILGWLAK
IAAPTTGRELAGRLMGGDKAARAALALPAVGDAYAVAGAKPIYRIPAYAIDHHPAEIGVP
TGHWRSGAHSYTAFFTECFLDELAHVAGTEPLSFRIGMLGGDARLARCLSTAASLGGWEG
GIPGSGQGIACHSFRGSHIAVLAEAHIDEGQVPVVDRIVAAVDCGRQINPDVVRQQIEGG
LIFGMAAALGGATTFTENVADARTFGDIALPRLADTPDITVEMIRSEADPGGVGELGVPP
IAPAIANALQASTGFRMRTLPLTPGEA
>A0A170QCS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MSQGYSRRDFLKVSSVAGAGLIIGVVLPYKHRLVAAGLVDQTFDPNVWISIHPDNTITIF
AAKSEMGQHIRTSLPMIVAEELEADWSQVRVAQADAHPDKYGSQGTGGSGSIRRSFTRLR
KAGAAGREMLIQAAANKWNVSPKNCRAESGTVIHLSTGNSFTFGELVETASELQVPENPV
LKNPKDFKLIGNAMPGLDTHSRVNGAAIFGVDVQVPDMVYATVLRCPTFGGKIKSFNRKK
AMKINGVLDVYEIDEGVAVVGKNTWAVIKGQRALEPKWDHGDFLSWDSARIKNMMEEKST
GKAVIAREDGDLTSLNGDEKIEVQYEVPFTSHATMEPMNCVAHVKKNSCEIWAPTQSPQR
VQTTAANALGIDTKNVIVHITMLGGGFGRRLWADFVTDAIQVSQKSKKPVKLMWTREDDM
GHDFFRPTSIHKLSATLSNQHELTSWTHRIIAPSISGQMAPERFKDGQLDRSAVNGASNI
PYDISNVLVDYIMANTKVPVGWWRSVYNSQNAFANEGFIDELAQKAGIDSYQFRLNLLKN
APRHLGVLKLAAEKANWGKKMAKRQGMGIALHESFGSWAAHVAEVTVTKTGELSIDKIVA
AVDCGLVVNPDGVKAQMESAIVYGLTSTLKGLITIEKGAVAQSNFHEFELLRIDEMPEVE
VYIVKSAEPPGGAGEPGLPPVAPAVTNAIFAATGKRIRSLPIRPKDLI
>A0A840ZNC7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodinum|TrEMBL
MRSVRQTSRPSRRTLLAGAGLFTLGFHIPGLVPARAATLDAGPDSPEVNAWVVVKPDETV
VIRIARSEMGQGTLTGLAQLVAEELDCDWARVTTEYPSPGRNLARKRVWGDYSTGGSRGI
RESHEYVRKGGAAARTMLVAAAAKGWGVPAGECRVERGTITHGPSGRSTTYGAVAAEAAR
IEPPKEVVLKDPKDWTLAGKPLKRLDTLPKLDGSQIYGIDLTLPGMLNAAIRDCPVTGGS
VKSFDAAAVSGMPGVKRVLQLGDSAVVVVADTFWRAKTALDALPVIWDEGPNGKVSSETI
AATLSEGLDAEQAFVGNRAGDVAGALKGAAKVVEAVYGVPFQNHATMEPMNATALWTPER
CEVWAPTQNGEAALAATAEAAGLSATSCEVHKIHLGGGFGRRGATHDWLRQAVQIAKEMP
GTPVKLIWTREEDMIHGRYHPVTQCRMRAALDADGNLTGLHMRISGQSILASVAPQRMVE
GRDPVTFQGLNPGGPEAAIGYTIPNILVDHAMRNPHILPGFWRGVNLNPNAIYLECFMDE
LAHAAGQDPLAFRLKLMGKHPKHRAVLEAVAQKIGWDSKPPEGVYRGLCQTMGFGSYVAG
AAEVSVSEAGELKIHRIVAATDPGHAVNPQQIEAQVEGSFVYGLSAALYGACTVKDGRIE
QTNFDTYPVMRMDAMPAVETILMPSGGFWGGVGEPTIAVAAPAVLNAVFAATGKRVRHLP
LKDTDLRRA
>A0A7X0AZI1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospirillum iridis|TrEMBL
MTETNRRRFLQVTGGAGVGLMVGFTWTATGRRALAAPAEAGKAFEPNAFVKVAPDSTVTV
LIKHLEMGQGVYTGLTAIVAEEMDADWAQMKAEAAPANAKLYNNSAFGPIQGTGGSTSTY
NSWTQLRQAGATARALLVAAAAQTWGVPASEITVSKGVVSSGKHSAKFGELAAKAATLPV
PADVPLKDPKDFTLIGTHLPRKDSVEKSTGKAVFAIDVAQPNMLVAVVRRPPKFGAKAQT
VDAKAAKAVKGVVEVVEIPRGVAVVATSYWAAHQGREALKVTWDESAAEKRGTDAIIKDY
KALLSTPGEQVTKEGDVDAVKAAKVVKAEFSFPYLAHAPMEPLTCVVKLGKDGCEIWAGD
QFQTVDQMNAAQAAGLKPEQITINTVYAGGSFGRRANLESDYIVEGVTIAKALSDAKVQG
GKLAGSPVKLIWSREDDIRGGRYRPIYVHGMEAKLGADGALLAWKHRIVGQSIMAGSMFE
QKGKPDNTSVEGAAEIPYDIPNRLVDLHTTTSPVPVLWWRSVGSTHTSFAVESFIDELAV
EAKQDPVAFRRTLMEKHPRHLAVLNLAVEKAGWGKPLPKGWARGVAVAESFRSVVAHVAE
VSQDDKGRLKVERVVCAVDCGIAVTPDVVKAQMEGGIGYGLGAVLFGAITMTDGTVDQSN
FDTYRCLRIDEMPKVEVHIVPSANPPTGVGEPGVPPLGPAVANAIAALTGKRIRDLPFTG
TVSV
>A0A7X0B4A3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospirillum iridis|TrEMBL
MTVGTLATIARRTFLIGSVAVVGGVAFGAYKVRRALPNPLLDDLPQGATALTPYVRIDAQ
GVTLIAPRAEMGQGIHTTLAALVAEELDVAWDSIHVEHGPPGAAYFNRELLKDNVPFADL
DHGFSAEATRGAMGVLAKLVPLQMTGGSSSVADLFDRMRVAGAAARYALVAAAAQKLGQP
AAQLKTDNGSVVAADGRRLTYVELAPAAAAIDLPDSAPLKPREQWRYLGKSLPRVDMVAK
CTGTATFSIDVRLPDMVFATVRMNPAMGAALVSFDATAAKAMRGVLRVIDLPGGIAVIAN
NTWRAFQAAQAVQCDWAGPAYPASTAAMLDGIVASMTDKHRDSRLRDDGNVDEALAGGKV
IQAEYRVPFLAHATMEPMNAVAWLHEGRIDIWAGVQNSTAARELAAKITGLDVAKVRLHV
TMMGGGFGRRLESDFVAQAARLAMAMPGKPVKMTWSREEDIAQDFYRPAAVARLHGAMVG
KQVTALDVQVASLSVAESSLGRLALPSLGADRKIIEGAFDQPYGIANYRATAYRTPAGRP
VSYLRSVGNSYNAFFMESFIDELAVEAGVDPLTMRLALLKHEPSRKVLAAVASMSGWGLP
LATGSGRGLAFHLCRGVPVGLVAEISATQKGVKIDKVFVAVDVGTALDPRNLEAQMHSGV
IFGLSAALYGEITFAKGAAEQTNFDSYQVVRMEQAPEIVVKVLESGGPIRGAGETGVPPA
APALANAIFHATGKRIRELPLQKHINFV
>A0A841MXB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MASYTLDINNKKHQVEVAEGTSLLWVIREHLGLTGTKYGCGIAQCGACTIHVDGEPMKAC
VLPVNNFSNGEKITTIEGLSENGDHPVQKAWIEAQAPQCGYCHSGQIMQAVNLLEKNPNP
SREEIKEHMNGNICRCGTYLRIIKAVELAAQNK
>A0A841MQ59|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MAKYTLNINGENKEVDAVEDMPLLWVIRDLLGMKGTKFGCGQAFCGACTVHLDGVAVRSC
SVQVSSVGDGQITTIEGLSEDGDHPVQKAWVEHIVPQCGYCQSGQIMNAAALLNSNSNPS
EAEIEQAMEGNLCRCGTYNRIKDAIVSASKSM
>A0A166ES32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. WM33|TrEMBL
MIRFQLNGNSVTTGVNEDAPLLYVLRNDFSLNGPKFGCGASACGACTVLVNGQAVRSCIT
PVSLVADSEVVSLEDQTPDSVLSVLQQAFLVEQAAQCGYCSNGMILTATELLSSNPAASD
AEIRESMDGILCRCGAQARVLKAIKRAQVQI
>A0A6J5KCH1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia phenoliruptrix|TrEMBL
MSQGLLDAHKGAKRPQADANETRGLSRRTFLKFGVSVGAAAGGGLLLGFSLPAISQDQKT
GKSVIGGDANEAPQNGVFAPNAFIQIDTAGKVTLVVPKVEMGQGVYTSIPMLIAEELEVP
LDTVTLDHAPPDEKLFTDPLLGGQLTGGSTSIRYAWEPMRRAGATARTLLVAAAAQQWQV
DAASCHAQNGQVIHAASNRSIGYGQLVEAAAKLPAPQNVPLKDPKDFRIVGTAVKRLDSP
EKVDGTAQFGLDVRVPDMVYAAIANCPVFGGTLASVDDTHAKKIPGVRQVVKIDNAVAVI
GDHTWAAKRGLQALEIKWNEGAGAKLSMKQIVDDLAHASERNGAVARKDGNVVQGFANAK
TRVDAIYQQPFLAHATMEPINCTVHVRADSCEVWLGTQVPTRVRDAAMAVTGLPADKIVV
HNHLIGGGFGRRLEFDMVTQAVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLG
ANGKPLAWQHRIVGSSILARFAPPAFKNGLDPDAVEVASDLPYDLPNQLVDYVRQEPHAI
PTAFWRGVGPTRSTFVVESFIDELAAEAKVDPVKYRRDLLGKTPRALNVLNTAAQAANWG
SAVPKGQGRGVSVMHAFGSYFAIIVDVAVDQGEVAVKRVVCAVDCGMVVNPNTVEAQVQG
GIIFGITGALYSEITIKDGRVQQNNFTDYRMLRIDQTPPIDVHIVKSSEAPGGIGEPGTA
ALAPALTNAIFAATGKRLRHLPVGSQLQTA
>A0A161XN83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. WM33|TrEMBL
MSVLSSRRGFLKGAAASAAAVLVIGVAPSGSMAAANAADTTMLNPFVKIAADGTVTAIVK
HFEKGQGPATGLTTLIAEELGVSMDAIEYEFAPSNPKLYNNTAFGPIQGTGGSTAMFNSF
KQYRQAGAAARDVLLQAASLAWDVPAAQLKLEDGVISGDGNKAPIGEFVAAASKLTAPEN
PRLKDPSEFKLIGNASVRRKDTPPKINGTAKYAMDIQLDNQMVVTIKRATRKGATVTSFD
DSAAKDVKGFIRAATLPNKAGVAVYAENTWASLQAREALEVTWDNSAAESRSSEDVYKEL
MAALNTAPEYNLTKNDQAEIAGAIENADKVVEETFYFPLLAHAPMEPLTCTIEATEDGGV
ILHDGCQMPTSPHAAIAQILQVPMDKVQVNTMFAGGSFGRRATPTVDYQVEAALSFVMTD
RRRPVKLVWSREDDITGGYYRPAFAHKVRVGLDADGNIAGWDHRVAGQSISKGTPFEAFS
VHDGVDHLSVEGVTPTQYSIPRMFAGLTDIKPATTVLWWRSVGHTHTAYVMEAMMDAVAT
AAGRDPVEFRLAHLAGDTPDQKRLTGVLKLAAEKSNWGKDAEGRSQGVAVHKSFGSYVAE
VVEISGDAENGVKIEKVTCAVDCGIPVNPDVIKAQMEGGIGYGLGHAMRDEITLENGEVI
QQNFPDYEPLRIGDIGEIETHIVLSTQAPTGVGEPGTPPSAPALANAIAAKGPRVTELPM
TKAGVTFA
>A0A7W6SHC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MIELTVNGTKHGIDVVPEMPLLWVLRDELGITSAKYGCGVAQCGACTVHIDGKAVRSCQA
HIGEVAGKSVVTLEGLDNKDQHPVLQAWIEHQVPQCGYCQTGQIMQAISLLARISKPTDE
QINQVMSGNLCRCGTYPRIRAAIHAAAAKKMAEK
>A0A7W6SIW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MPDTYEKLRVAGAVARETLKAAAAKRSGVAVADLRTESGHVILPNGSRIAYVALAAEAAK
IPPVLDAKPRDPSKWRMLGKPMQRLDIRAKVMGELKFGIDMKMDGMLYASVKLNPGKGQP
LKSYDASKARAMPGVKKILEIKNGVAVIATNSWYAMEAVDAIACEWAPSAYPAEQADHWK
VLESSFKPEFLGKEWRKIGDIETGLKTGTRVEAEYRAPYVAHQPLEPLNGIGLVTDTGME
IWVGHQSPRFVQWVAATAIGLKPEQVTFHNQWTGGSFGHRLEYENVRVLAEIANQMKGTP
IKLVFSREEDFLQDIPRQIAIARHRGSVDKSKIVAADLQLASTAPLKGLLERSGTPSKDP
DGQLAAGLWNVYYDIPNFRATSYEAQGLSPSTTWRSVGASTSGFFTESFIDELIHAAGLD
PMKARIAMCTVPHYRKVLETVAEMSDWKGPLGNGRGRGVAFVESFGTPTAEVVEVTATDR
GIRIDKVWVAADVGKVIDPVNFEGQVQGGVVWGLGHAINCELTYSKGAAQQTNYNHHEAM
RIHQCPVIEVRGLENDPKVRGVGEPPVPPAAPALANAIFAATGKRIREMPFNKFIDFV
>A0A0H2MNG4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax paradoxus|TrEMBL
MIDLNINGQSVAVNAPEDMPLLWALRDIVGLTGTKFGCGIAQCGACTVHLDGQPVRSCVL
PVGSIGKKAITTIEAVSQTPAGKSIQKAWLDVDVVQCGYCQSGQIMSAAALIQRTPNPSD
ADIDLAMSGNVCRCCTYSRIRAAIKQAATGKAEVLQSVVAMPARSAS
>A0A0S3PW85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variibacter gotjawalensis|TrEMBL
MNIQFDPSAKTSIRNISRRSILKGLFGTSAFVLAAQFPLARRGFAYPTGAEKMPNGVKTD
PKLFVAIDKDGTVTIMAARAEMGTGAARTSLPMILADELEADWSRVKIVQANGDETKWGN
QDTDGSRSVRHWIQPMRECGATARRMLEQAAAKRWNVAVADVEAVNHEVVHKASGRKLGY
GELATDAAALPTPTDFKLKDAAAFRYIGKGNTPVVDLVDITTGHAIYGQDAMLPGMKFAV
VARPPVVGGKVASVDASAALKIPGVEKVVQIPATPLPAKFNPLGGVAVIATNTWAAMKGR
EALKITWDDGPNGSYDSKAYKASLEANVRKPGKVERNEGDIDKAFAGAAKTFAQEYYVPH
WAHAPMEPPAALARMGGGKFEIWAPVQSPGGARDDTAKFLGVKPEDVLMHTTLLGGGFGR
KSKCDFAMEAAFLSKELGGTPVKVVWTREDDIQHSFYHTVNVDRIEAALDANNKVVGWRQ
RSASPSILSTFAPDPKHPFAIELGLGFVDMPFAVPNIRLESGEAAAHTRIGWFRAVNNVP
HAFAVQSFVAELAHELKRDPKDMLLELIGPDRKVDVSKSVTTEWWNYGEPFETFPVDTAR
LKNVVQLVAEKAGWGRQMPKGSALGIAAHRSFVSYIATVVEVKIDDKGNITVPRVDTAID
CGFAVNPERIKSQIEGASVMGMTIAKYSEVTFAKGRVEQTNYNDFPIVRMEDSPQLTNVH
IVPHGIDTPPSGVGEPGVPPFAPALCNAIFAATGKRIRSLPIGNQLA
>A0A2Z4UPF7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobiaceae bacterium|TrEMBL
MTISVTINGKGHELDVEPDMPLLWVLRDELGMTGTKFGCGVAACGACTVHVNGEAMRTCT
LPVEAVADAEITTIEGLNKEGPDLTALQQAWVDHQVPQCGYCQSGMLMAVSSLLSENSNP
SDDEIDAAITNICRCGTYPRIRAAIRSLATA
>B8KKA4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|gamma proteobacterium NOR5-3|TrEMBL
MISLSVNGEQRDLDVDPQMPLLWAIRENLAMTGTKFGCGIAQCGACTVLLNGKAIRSCVI
SVATAEGGEVTTIEGLADLVPGDGLHPLQEAWIEKQVPQCGYCQSGQLMSAAALLDSNPN
PDDAAIDAAMSGNVCRCGMYSRIRSAVKLAAAQTGSVVQTFDPAVTTDLEGADHG
>A0A1E3H5U5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MNGPHVRTSVLSRRSFLVSAGGLTVAIALLPHAGHAAVPADLPTGPFRPNAWVAIAADGA
VSIISPAAEMGQGVMTTLPLVLADEMDADWDQVRVVQAPSDAENFGNPGFYGIQLTGGSE
AVRGYWDTLRLIGAQTRMVLIAGAAAVLDAPADELTTEPGRVLHPRSGRSLGYGEIAASG
ALPAPLPEATDADLKPAERWRYIGRRDIGRIDVPAKVRGAAVFGIDVQLPGMLYGAVLRA
RSRGIGRRSWTTRRPGPSRAW
>A0A7W7XBE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces nymphaeiformis|TrEMBL
MRDDDHTSGTEGGGPGIGRRRFLGYVLAAPTLTVAAQLGAEALAPREAAAATPALIPSLP
GPAELLDLNELLTIAALPTSNLITIRVDADGTAHFALPRAEVGQGVTTSSAMIVAEELDL
PLDKVKVTLADARPELLFNQLTGGSNTTYSTYTPIRVAAALARGRLLHAASVVLGQAVET
LTTKAGAVVSPAGALLGYGELAVKAAAVTDAAVEVTLKDAGDFRVIGTGQRRMDALEAVT
GRKKFAMDLQVPDALPTMICRPPTINGTVRSVANLDEVRAMPGITDVVTVSTGVAVRGRT
FGQCVDAVRALRVDWGPGTAEGASDATILEKLRRAELPLVVPPLPLLTKAVDARFTFHFA
SNAALETNCAIADVRKDSAEIWASLKSPIVAQEQIALKLGLPPTAVRVHVTEGGGSFGRK
LFSDAAHEAAEVSKALGKPVKLMWHRTDDFRQGRTHPMSTSRVRATYSLGEILTYEQRHT
SVATDFGHGIGEVLTAEAARLPVADATFSETMFQLTQISPYHLGVTTQLLAETDKGFNTG
SMRNIYSPNVRCAQELVLDELAERTGQDRYRMRRKLLKDGRARAVLDKVAEVGQWGRSMP
AGTGQGIAVHTEYHSAVAILAEIDCRPETTGRKIPGAYTGPRVTKVVCAVDVGLAVNPRG
LEAQMMGGIADGIAITLTSGLHLSDGHFLEGSWDQYFYTRQWNTPPELEIIVMPPSGDKP
GGAGELAVAGAMAAVACAYGRATGTMPTVFPVNHAEPLAFTPLPTVPPVPASPTDGRDRT
I
>A0A2N7RTG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. AD80|TrEMBL
MITLNINGRDTQVDADPSTPILWALRDNLDMTGTKFGCGAALCGACTVHLDGQPIRSCIT
PISSVGAQKITTIEAMENDQVGKAVQAAWVRHDVPQCGYCQSGQVMSATALLRTNKSPSD
ADIDGAMSGNICRCGTYQRIRAAIKDAAKTLA
>A0A7W5IM26|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WP4_3_2|TrEMBL
MTTLTINGETHTIDAPPDMPLLWVLRDIIGLTGTKFGCGIAQCGACTVHLDGEATRSCVL
PVAALEGRKITTIEAVGATPAGQKVQKAWREIDVVQCGYCQSGQVMSAAALIAQNANPTD
ADIDAAMAGNICRCGTYSRIRAAIKQAAKEA
>A0A0U5FAE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ghanensis|TrEMBL
MELNINGIQHHVDVEPDTPLLWALRDDLAMTGTKYGCGLAQCGACTVLVDGQAVRSCVTP
VEKVAGASITTIEAIEQDDLGKRVVAAWVKHQVPQCGYCQSGQVMAATSLLRQVPHPTDA
DIDAAMVNLCRCGTYNAIRTAIHDLASGSTDGGA
>A0A0S4HMQ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MNSILDVSRRRFLKGSVLLGGGLVVAFVIPGAHCFAVGAENEGNIFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWTTIRVEHSPASAADYGLAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIQAAAKRFDVAPSQIRTESGVVIAGDKRATYGELADDAGKL
PVPDPASIKLKEAKDWKVIGKPTKRLDTPEKITGRATFGMDVQFDGLMTAMVARSPVFGG
SVKSFEGAEALAVPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVDWDLGPNTGLDSQKL
LESFRKLAATPGRSASKAGDATAALGKATKKIDVEYSVPYLAHAPMEPLNCTVKISEDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAG
APVKTVWSREDDIRGGYYRSMFLHQANIGLDAGGMPIAWKHVMVGQSIMDGTAFAATMVK
DGVDKTSVEGVADSPYLEDLANHEVELHSPKTGISVLWLRSVGHSHTAFVMESLIDELAE
AAGKDPVEYRRTLLKNHPRHLGVLNLAVEKANWTAPLPDGHALGVAVHESFGSYVAHVAE
VSQDNLKIRVHRVVCAVDCGIAVNPMSIAAQMESCITFGLGFALHSKLTFKDGEVVQSNY
HDYQVLRLNEMPVVEVHIVPSTERSGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>S7X387|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cyclobacterium qasimii M12-11B|TrEMBL
MIPSFPFLKKKSVKNTSKVFLPSRRGFLKMGSLAGGGLLLGVSFQCTSSKGQEENFAPNV
YLSISPENTVTIIAHRSEMGQGIRTSLPMIVADEMGADWTQVKIVQAEGDEAKYGNQNTD
GSFSVRMFYEPMRKAGATARHLLIKAASQEWGVEASTCTAENGNVSHAESGKTLSFGELA
HAAQQLPLPDQDSLELKDFSAYKLVGKDTPIIDLKDFVTGKAVFGADVNLPGMKIAVIQR
TPVVGATLTSYKAEAALAVPGVQQVVKINGSGNPPGLTKPLEGLAVIADHTWAAIKGREA
LDITWDLGDNAAYDSKVQLESMKQSTLEEGMVRREKGDFNQAKQGASQVIERTYEAPFYA
HGTIEPPAAIARFTDGKMEVWAPTQHPQWARDTVAEVCGLSVENVRVNVTLLGGGFGRKS
KPDYVVEAALLALETGIPIRVQWTREDDLHHDYFHSHSVQRIRATLDASKKLTGWNHHTV
FPAIGATSDANELHPSDGELGLGCIDYPYEVPNIRIETHPSKAHTRIGWMRSVSNIHHAF
ATCAMMDEIAETIGKDPVQFSLDMLADDKHLDFAGEIKGDFGNYGESLEDFPWETARLKH
VIKKVAQESGWGKPLPEGRVMGFAVHKSFLTYVACVVELERDDAGKITIPLVHYAVDCGI
AVNTDRIRSQFEGGAIFGTSIANTSAITLKDGMVEQNNFDSYQLVRMPQSPKKINVHIIE
SSIKPTGIGEPPVPPLAPALANAYYKLSGKRVYALPFSLE
>A0A5E6UC69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDALAEDKPKQFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELDADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWTVPVGECHAQLHKVIHKPSGRALGYG
ELAAAASALPVPARESLRLKQPSEFRYIGKEGTKAIDGDDIVNGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVLKVIQIESRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQAPMEPMVAIARYKDGVCEAWAPSQAPQVTRERLAERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGVGKDGMPSSWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGEDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEIAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A3S5E9R8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRVPNDFALSNLSRRGFLKGVGATSALVLAASWGWHDALAEDAPKKFGADGMPNGWIDD
PKVYVSIAADGSVTVVCNRSEMGQGVRTSLSMVVADELEADWAQVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHKPSGRELGYG
ELAAAASALAVPARDSLRLKQPSEFRYIGKEGSKAIDGVDIVNGRAIYGADVHFDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVLKVLQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLTPGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQAPMEPMVAIARFKDGVCEAWAPSQAPQVTRERIAERLGVAFEKVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKASVDNNGMPSGWL
HRTVAPSITALFAPNMNHEAAFELGMGFTNMAYAIPNVRLENPEAKVHTRVGWYRSVSNI
PHGFAIQSFVDELAHNAGEDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGSLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRDLPVRYQLQGWQKTEA
>A0A5E7RPS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVTTIDNLNADPVGKVVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A3S4T0M4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSEANGLNPSRRAFLRGGALLMAFTLLPVARRALADTEVDTLGTVVLAPDLPGSLRTNPY
LDAWIRIGADGITVYTGKVELGTGVKTALLQIAAERLQVPASAINLLTADTALTPNEGYT
AGSHSIFDSGTALYNAAAQVREMLVEAAARHWQSDAALLSTRDGVIEGPAGQRMAYAEAV
KHVDVHQYAKAESPAMAAADFKLIGHDLPRLDIPAKVSGGAAFVQDMRLPGMLHARVIRP
PRPGCTLQAFDAASVEALSGVVKVIRDGNYLAVVARDEWQAIKAMRSGMESAQWAGGEAI
PDAAGIHDLLKRLPSKRYPISNAGAASGSTDTRFKARVTKQYLMHGSIGPSCAVAWFNDG
VLTVWTHTQGVYPLRAGIAEMLRLPPERVRCIHTEGSGCYGHNGADDAAADAALIAMRLP
GTPVRVQWMREQENFWEPYSSAMVVEVDAGLSQHRLQDWSYELWTTPHNERIVNAGRLLP
ARLLARPFTSAPSVPIAQPEGDGDRNAVPLYDVGATRINMNFVTEMPFRTSAMRSLGAHI
NIFAIEASIDELAIQAGIDPVALRMAHLDDPRARAVIERVRDSIGWPHKSNEPGAGIGFA
FARYKNIMGYCAIAVKLRVHPQTGEIRVDHVVTAVDVGQIVSPDGLRNQVEGGIVQSASW
TLYEKVAYDAGGIRSYDWSGYPILRFTQLPKKVDVHLLDQPGKPFLGAAEIVQGPMAAAL
GNALANATGRRWLNLPLTRSTQPA
>A0A5E7SCV5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIEFTVNGERRELVETSPSTPLLWVLRDHLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPVAAAAGHSITTIEGLSPTGQHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
ESIRDAMSGNLCRCGTYGRINKAIKRAASAPKEA
>A0A448DVS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQITLNVNGAAQALELEPDMPLLYALRNHLNLNGAKYGCGLGQCGACTVIVNDQPVFAC
LTPCAGLEGKKIRTVESLGSAEKPGPLQAAFIEKQAAQCGYCIAGMLMRAQSLLEQDPHP
DEQTIREHMAGNLCRCGTHLRIIEAIKQVAGHNGSLT
>A0A448BN64|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSDALALTVNGQSLRLDVAPDTPLLYVLRNDLQLNGPKFGCGLGECGACTVLMDGVATRS
CITPVEAAVGRRVVTLEGLGDAAHPHPLQQAFIDEQAAQCGYCINGMVMTAKALLDRNPN
PSDGEIRQELAYNLCRCGTHVEILKAVRRAAESLKEHQEEHPA
>A0A5E7HPQ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSIKPLSRRGFLKGSALLGGGLVVAFVIPGAHRFASGAENQGMVFAPNAFLRIGNDDSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAADYGLAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSQISTESGVVIAGDKRATYGELADDAGKL
PVPDPASIKFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVVQVPTGIAVIADHYWAAKLGRDALKVDWDLGPNTGLDSQAL
LENFRKLATTPGVSASKAGDTDGTLGKAVKTVDVEYSVPYLAHAPMEPLNCTVRITQNKC
EIWTGTQFQTLDQMIAGKITGLTPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
APVKTVWSREDDIRGGYYRSAFLHHARIGLDAAGQPIAWKHVLVGQSIMAGTSLEATMVK
DGVDKTSVEGVADSPYLAGLAHHQVDLHSPKTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVDYRRTLLKDHPRHLGVLNLAVEKAGWKTPLPNGHALGVAVHESFGSYIAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKDGQVEQSNY
HDYQVLRLNEMPLVDVHIVPSSEKPGGIGEAGVPPVAPAVANAVFALTGQRLRELPLQLS
GV
>A0A0D0H8Y8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia sp. MSHR3999|TrEMBL
MIRCERKLTGTKFGCGVGICGACTVLLNDQAVPACQIPVGTLNGARITTVEGLDSAEARA
LKDAWLAVDVVQCGYCQSAQLVAATALLMRCPRPDDRQIDEAMKNIACRCGTFPRIRKAV
HKAAESVGPVHANNGLALAARRAEREEWDEANTQRIRKEHDAAIGPSGGQPHK
>A0A7W6LSH1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium scionense|TrEMBL
MAISLKVNGQTRSVEADPAKPLLWALREDLDMVGTKFGCGAGLCGACTVHIDGNPARACQ
TPIGEAQGMAITTIEAVAKSDAGKRISDAWVKLDVPQCGYCQAGQIMSATALLATTPDPS
DEDIDAAMMGNLCRCSTYVRIRAAIKDAARAGAKA
>A0A0P1E7D6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MTINTSRRGFLKGAAAAGTVLLVGARPDGALAAASSETAQFNPFVKIDADGTVTAIVKHF
EKGQGPATGLPTLIAEEIGLTMDQIEYEFAPSNPQVYNNLLFGPFQGTGGSTAMANSWMQ
YRQAGAAAREMLINAAAQSWGLDASGITIEEGIVKAGDKSVPIAEFVAAASQLEAPIEPR
LKDPSEFRLIGNETVRRKDSAIKGNGQAMYAMDVHLPNQMVAMIKRPESKGGIASGFDDS
ASKEVKGYISAAILPNQAGVAVYAENTWAAIQARDALEVDWDMSGSETRDSDQIKAEIMA
ALDAEATYNVNKADVAAVSAAIDSADMVVEKTFYFPLLAHAPMEPLNCTIEQTAEGDIVL
HDGAQMPTGPHMAYQQIFQLPPEKIHIKTMLAGGSFGRRATPDADYQVEAALAFVVTDRS
RPVKLVWTREDDIRSGYYRPAFGHRVRVGLDADGKIVGWQHQVAGQSVIKGTPFEAVAVH
DGVDHSSVEGIADSPYDIPGMALGLTDAPKATTVLWWRSVGHTHTGYVMETMMDTVAEAA
GRDPVEFRLSHLADTNNADQQRKAEVLKLAVEKAGWGNAPAGRAQGIAVHKSFGSYAAQV
VEVSGDPENGIKIEKVTCAVDCGIAVNPDVVRAQMEGGIGYGIGHVMRDQITLTQGAVDQ
YNFPDYEPLRIGDIAEIDVHIVPSAEAPTGVGEPGTPPSAPALANAIRALSGVKVTTLPM
VENGVSFV
>A0A0P1E6I3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MASVGKILRRTFLIGSAAIVGGVAFGAYYVSRPAANPLKPAEGETALSPFVLIDQQGVTL
FAPRAEMGQGVRTTWAALIAEELDVELDQIRVLHGPAAAAYYNSALVGEGLPNKGYDISD
FQHNLGEALGVLGRTLSLQVTGGSTSMKDGFERMREAGATARETLKQAAADRLGVDRAQL
KTENGAVIAPNGTRIPYTELAEAAGQIEPPEVELRDPSNWRLLGRNLPRVDVVGKSTGTA
EFGIDVRPEGLKFASVRINPKLGGEMKGFDASAAEQMPGVKKVVDLGNGVAVIATNTWLA
IQAVEAIDVDWGDAPYPPETDAIFTEIASAFDASPNSTMRDDGDVDTLPDGATEITAEYT
VPYLAHSTMEPMNATALFTGSALELWCGNQAPTLVQIRAANTANLDKEAVQIHTTYLGGG
FGRRGELDFGEIATKVAMAMPGVPVQTTWSREEDMRHDYYRPGAMARMRGAVKDGQAVLI
DGKVAAQSCTQQAVKRYTGLPAGGPDKVLVEGFFNQPYTVPNYRMSGHIADLDIPVGFWR
SVGNSHNGFFHETFMDEMANAAGRDPLEFRLELAKAEHAPSAGCLQAVKEMSGWTGETPD
GVGRGVAMTYSFGTPVAQVIEVVDEDGTIRIAKAWIACDVGLALDPGTVEAQMFGGMIYG
LSAAVMGEITFSDGEVEQYNFPDYDALRMHNAPVTQVKILETNHHMGGVGEPGTPPSMPA
LGNALFDLTGERARTLPLINQFNLLV
>A0A0P1EBE2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MALTLKLNGETHTVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLNGEPVRSCQ
TYIEDVEDAEITTIEEVGDDKIGAAIQQAWIELDVVQCGYCQSGQVMSAVGLLSENPKPS
VEEIDDYMHGNACRCATYQRIRAGIQRASEILEA
>A0A0U5EY41|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter senegalensis|TrEMBL
MRNALFDAMGEVPVNLSRRRFMLSSAGVAAGAFVLGIAVPQRTARADATKLRGTKVPAFL
EIRPDSTVRLQSPFVEGGQGTFTAMAQIVGEELDADPATFVVENAPPGDEYVVMDNGMRI
TGGSMSIRNGYPAMRRLGALAREMLLQAAARQFDVPVEELTTQPGRVIHKPSERSIAYGD
LAHAAMSLPVPDPATVRLKEPGQFRWIGAPVPRVDVHDKSTGKVVYTVDVSVDDMLHAAV
QHAPRLGMIIQTVRNEDQVRAMKGVHSIHRLPGVFAVVAERWWDAKRAAEAALIDWQEPG
ADTTMRVMPADFSTEAFRKDLADARGSGEDAETRGDVTRGLKNAHTVVEATYSSQYVNHA
QLEPPSALARFSPDSTLEVWVPNQAPDMFRADIAKRTGLPVEKVVIHSQMLGGFFGRHFL
YETASPYPQAITLAKETGRPIKLIWSREEEFLRDTLRPMAAVRFRGGLDENGIPVVLEAV
SATEGPTEGLNNKRGDKLDDSALEGLTGKSYDIPDRRIAQHFIKSPVMLGYWRSVGNSMN
DFLYETFLDELADKGNQDPYELRLRLLRDNKRLTTLLKELADLSGGWKRGPFTAADGSRR
ARGIGMASPFGSEAAAIAEVSLENGRVRVHEVWEAIDPGKVVNPAIVEAQVNGAIALGLS
QVLLEETVYENGMPRARNYDGYPILALNQMPRVHVKIVESGEKMGGVGEPPLPAIPPAVA
NAVSTLTGRRIRSMPLSRHDFAS
>B9BGS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD1|TrEMBL
MITLTLNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRSCIT
PVAAAAGKHVTTIEGLSADATHPLQQAWQELNVAQCGYCQAGQIMQAASLLKTNPRPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAVSRGGAA
>A0A7W6YTF4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium leguminosarum|TrEMBL
MTKTSLPRAVALSRRSFLVTVGGTAVTVAFASLSSVALGAATAQAATGDFTPNVWVTIAS
DGIVSIISPASEMGQGVMTSIPLLIAEDMDADWDMVRIVQAPADAEKYGNPNFGGAQLTA
GSDTTRGYYLPLRLVGAQTRKILLAIAASRLKVPVSELTTEPSRVVHLPSGRSLGYGEIA
APGELPDVLPQVSEADLKPIDQCRYIGRMDVNRIDVPSKVNGTAKFGIDVELPDMLYGAV
LRSPVPGEAPESIDDAAARAVKGVIQVVPLRNGVGIIGESYDAARRAKEVLNITWTNSSS
VRRYNSTRLVEAYRDVGRDLAQAGVISHTQGADAAAAIAGAARVIAADYLSDHVHHVTME
PMNATALVSSDSVEVWAPTQGPGTARDVAARIGGTTPDKVKVHTTLLGGGFGRRAEQDFV
IEAVLLAKAVQGRPVKVIWSREDDVRHGKYRPLAAQHLQVGLDASGNIVGWHHRLVADSI
LARISKDRFQRAGGQDSLVTDGTIHNYRVPAHLVQFVRQDNGQDVGSWRAVGNGYTKFAI
ECVIDEVAAAKAVDPVAFRLELLSEQPRARKVIEAVAAMAEWNRPRNGRALGIAYSDAFE
AHCAEVAEVSLDRESGEIRVHNVWCAIDPGVAIQLLNIEAQVAGAIVHGASHALYEQLNI
VDGEVQESNLDTYRVMRMSEMPQIHVRIMPTPENRPAGIGEAGLPPVGPAIANAVARLTG
GVRLRHYPFLPERVKAALSS
>A0A4U9VAL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia fonticola|TrEMBL
MRCLYRTDRRRCGRSCSTPLSAAQGKAITTLEGLSQEGHLHPVQQGFIDEQAAQCGYCTN
GMIMTLVALFERDPEASEQQIKNELAFNLCRCGTHLEILAAAKQAKRLLAERGAQ
>A0A1Y5TAW6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoruegeria aquimaris|TrEMBL
MTPKTSRRSFLKGAAAAAGAALFIGARPDGALAASSSDAMLNPFVKIDSEGNVTAIIKHF
EKGQGPATGLSTLIAEELGLRMDQIHYAFAPSNPQVYNNLLFGPFQGTGGSTAMANSFMQ
YRQAGAAARELLIKSAAEAWGVDPAGLSIEEGMVVGAGRSAPIGDFVAAAAQMEPPAEPR
LKSPEEWRIIGNESTRRLDSVIKGNGKAKFAMDVHLDNQMVVVIARPEQRGAMATGFDDS
AAKEVKGFINAAVLPNKAGVAVYAENTWAAIQAREALSVTWDTSAAETRSSDEIRAEIMA
ALDAEPEYNVLKKDHAETLAAIEGAAQVIEKTFYFPLLAHAPMEPLNCTIEQTAEGDIVL
HDGAQMPTGPHMAFQQIFGLPAEKIHINTMLAGGSFGRRATPDADYQVEAALAFVMTDRS
RPVKLVWTREDDLRSGYYRPAFGHKVRVGLSAEGEILGWDHRIAGQSIMKGTAFEAFAVH
DGVDGSSVEGVSDTPYRVPGMFVGLTDTKKATSTLWWRSVGHTHTAYAMEVMMDLAAKAA
GRDPVEFRLVHLAGGGADQARKAAVLKLAAEKAGWGKAQAGRHMGVAVHKSFGSYAAEVV
EISGTAEDGFRIEKVTAAVDCGIPVNPDIIRAQMEGGIGYGIGHAMRDQITLAGGAVEQY
NFPDYEPLRIGDIGAIEVHIVKSTEAPTGIGEPGTPPSAPALANAIAAASALTVADLPMV
EHGVSFA
>A0A094YJQ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter tropicalis|TrEMBL
MGKLERIAAQQDRAAGRGPTRRGFLLTAAGSAFLFGFAREAKAAQTFPASAGLPGDGAFE
PTIWCSIAPDGVVNVNVIRAEMGQHTGTALARIIADEMEADWDKVKITQVDTDPKWGLMV
TGGSWSVWMTWDVFRQAGAAARTVMVEEGAKLMGVSPASCIARNGRVVAGSKSISYGDIV
SRAHPTRTYTPDEMAKLPLKPASERRLIGKDVKALDIPAKTDGTAIYGIDAKLDGMVYAR
PKLPPTRYGSKVVSVDDSEAKKIKGYIRYIVLEDPSDTVPGWVAVLASSYPAAIRATDAL
KVTWTPGKTANVSEKDIIEHGRKQIAEKTGGSCVFNDSGVDEAFSSAKQVFERTYTCASV
LHYQLEPMNALARLQDGKWEIHCGNQWQSLFLPVIAKALQVPESQVVMRSYLLGGGFGRR
LNGDYAVPAALISKALDGKPVKLILTRSDDMLFDSFRSPSIQTVRVALDDQKSLKGWEHH
ASAGWPTGVMAAAFMEKGADGKPYDQFAIAGADHWYDVGPMRVRALDNDLADATFRPGWL
RSVSSGWTPWAHEAFLDELAHELGKDPVDFRLSLLTAKGRNVGSAPDSVGGATRQANVLK
RLVEKCGYGKVQLPADTAIGIATTFGQERAMPTWTAGAVQVHVDRKTGVVTCQKIWLVLD
AGTIVDPDGAAAQTEGGALWGLSMALFENTEIVNGNVRDRNLNTYTPLRISDAPEIDIEF
VESTEKPMGLGEPGVTTIGAAIANGVFNAVGVRLRHQPIRPADVLKGLAEKKSA
>A0A094YM99|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter tropicalis|TrEMBL
MELNINGIQHHVDVEPDTPLLWVLRDDLAMTGTKYGCGLAQCGACTVLVDGQAVRSCVTP
VEKVAGASITTIEAIEQDDLGKRVVAAWVKHQVPQCGYCQSGQVMAATSLLRQVPHPTDA
DIDAAMVNLCRCGTYNAIRAAIHDLASGSKDGGA
>A0A0U5MFJ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Magnetospirillum sp. XM-1|TrEMBL
MYSLIVNGERHKVDAQPDTPLLWVLRDQLGLTALRYGCGQGQCGACSVLVDGEPARACQL
PVSEINGRRVVTLSGLNDAVAAQLRAAWIELDVPQCGYCQSGQLISAGALLRRNPKPSDA
DIDNAMSGNLCRCGTYQRIRAGIHLAAKRLRGGA
>A0A0R0LQQ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ferrovum sp. JA12|TrEMBL
MALSISRRDFFKLVAVAGGGFAIGLNHDALADTQHNTFTPSPWVKIEPTGLITILVDKSE
MGQGVNTALPMLLAEEMDADWQKIRVVFAPSDPIYAHPWFHTQATGGSTSVRAMWMPLRQ
AGAAAREILRQAAAKKWQVSVDSVHIKNGIAHSGFHRATFGDLANIASTLPAPSEVKLKT
PEQFNFIGQSIPRVDNLAKSTGRARFGMDIQLPGMLIAGVIRAPHPGAKVVSFDADKALK
IKGVHYVLKVSSPVSEGVAVLANNTWIAFEARKAVTVQWDKAVDSGFNSDALLEKMKRLV
AGGEQTLTAVDRQQSTDNLTASNKITSTYYAPFLAHAPMEPLNCTAWVQHDQVEVWVGTQ
AQGPNQQMISQLTGMPTQQVHVYTQYLGGGFGRRFAPDFVMEAVVLSKQILTPVKVVYDR
TDDLTQYYYRPAALCQLEGAIDHNGQITHLRAITATDSIAQGTGFEKALIKGGVDQTSVE
GLHDIPYTIPNFKVEWANLNSGVRTWFWRSVGHSQNSFFSECFMDELAHLAQVDPLEFRL
KHLANHSRHYAVLQLLQDKSNWHSTLESGHARGVAIVESFGSVVAQMVEISLVDNTPKLH
RVVIAADVGTVVNPDTVKAQLEGAMVFGLSAALYGEVKFKDGHPQVNNFSDYPVVRLIEV
PPVEVYLISTHDHPGGVGEPGTPPIAPALCNALFVLTQKRHYQLPIVVNA
>A0A644XQN4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bioreactor metagenome|TrEMBL
MTTQVSINGQDQAVQADPQTPLLWVLRDELGMTGTKFGCGMALCGACTVHMDGGPIRSCV
TPVSAAAGKQIRTIEHMENDRVGRAVQGAWVALNVAQCGYCQAGQIMSAIGLLRSNASPS
DEDINNAMSGNLCRCGTYNRIHAAVKHAATQLAKGGQ
>A0A644W5T8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bioreactor metagenome|TrEMBL
MIEFSINGRAVSLDVDPDTPLLWVIRDEVGLTGTKFGCGIGMCGACTVHVGGRATRACIT
PVSDVAGAEITTIEGLDPAGAHPLQQAWRALKVPQCGYCQSGQIMQAAAFLKDIPNPTDA
DIDAVMTGNLCRCMTYNRIREAVREAAAAMRGEKTNG
>A0A1Q8L8C2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae706_Ps2|TrEMBL
MSAPTRARAERRDVSRRRFLGYLVAAPTLVVAAEVGRQQLFAPPGASAAAIPSPPQVADA
YDLLDAIRDSSRPTSALVRVEVNRDGTVSFELPRSDNGQGIITSTAMIIAEEMDLDPDQV
RVTLADSRPELVFNQLTGGSSTTFSTYTPIRVAAAIAKGRLLDAAAALLQQDANTLTSRA
GLVTGAGGSAIPFGELTEAAAVDATRSVEVVLKPREEFTVIGTDRRNAQARDIVTGRKQF
IADLKIPDALPTVICRGPGLNCAPLSVANADEVRSMPGVTDVVDCATGVAVRAHTYGQAV
DGVNALRVRWDAGTVEGESDESVLQKVRAAELPLAVPSVPGETVEGDFTFYFRSSSALET
NTAIADVRDGRCEIWTSLKIPITVQHDIAEQLGLPVNAVTIHIVPGGGSFGRRLFGDAAK
EAAEISQKLGKPVKLIWSRADDSRQGRVHPMATSRIRAVVSGESVVSFEQRHTGVACDFG
HGFGDAVTAAAAKAPLGQVSVAEAIWELTQATPYDFGVQTRLLNEVDMRFNTGSMRNVYS
PDVCTARDLIVDRIAEKMGKDSYEFRREFLRNDAMRAVLDKVAEEGDWGRSMPDGTAQGI
GFHVEYKGFAACLVEIDCRPQTVDRKVRQARTGPRVTKAVFAVDGGLVINPLGFKAQIMG
GINDAIAMTLTAGLHLVDGHFVEASWDNYFYTRQWNTPLDLQVHLVDNGRPEPGGAGEFG
VAPTCGAIANAYARATGRVPDHFPILHNEPLPFEPYPTVPPIPPSPTNGLDFAR
>A0A7W6LHJ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium rhizoryzae|TrEMBL
MSNTFFAPRLNRRNFLKASAALGGSLVVNLGVAANSLLAAQEFAPNAFIRIDRRGLVTFV
MPQVEMGQGIYTAQAMLIAEELDVSLDDLRIEAAPVNEALYGHPMLRRQTTGGSTSIRAF
WTPLRVAGATARRLLMQAAATEWNVDVASCRTQDGFVLHPDGRTRRAYSELVDRAASLPQ
PPAEAITLKQPSDFKLLGTARKRLDTRGKTNGTLKYGIDALPAGTRIAAIAISPVLGGKP
ISVNQTAALAIKGVRQVVITDDSVAVVADHTGAAKKGLEAAAITWDDGPNRAVSQVDILR
LLDEKSQQAGAVARSEGDVAAALSAAAVRIDAVYQLPFLAHTAMEPMNCTVHVRNDACEL
WVGTQNMSSAKQATAALTGLPPEKVIIHNHIVGGGFGRRLEVDGIVHAVKIGKQVKGPVK
VIWSREEDIQHGYYRPYYYDRLSGGIDGAGNPVAWSHRISGSSIFARIAPAAMRNGVDPD
GVEGASHLPYKLPAIHVEFKQVEPQGVLTSWWRGVGPSHNIFVVESFIDELAAAAKMDPV
EYRKRLLSENPRALKVLQLVAEKAGWGNVLPERQGRGVAVQFAFGTYLAMVADVSVAKDG
TVRVTRIVTAVDCGLTVNPDTIAAQMEGGALYGLTAALYGAITFSEGRVEQGNFDTYPPL
RIDEAPHVETHIVPSAEAPGGIGEAATSAVFPAVTNAIFAATAKRIRTLPINPEDLKA
>D8IP18|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Herbaspirillum seropedicae (strain SmR1)|TrEMBL
MHKQEPITFHVNGVPVSLDIAADAPLLNVLRNDLCLNGPKFGCGLGECGACTVLVDGVAA
RSCVIPLAGVAARHVTTLDGLEQDGRLDPVQQAFIDEQGAQCGYCLNGMIMTIKALLLRS
PTPSEDEIRHELDFNLCRCGTHVEILRAALRAVELQRGRQ
>X5MLS1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Phaeomarinobacter ectocarpi|TrEMBL
MNKWSRRGFIGAGLAGGTALVVGVAIRPGNPVGDLAKDAAFDGEQLVNAWVKIGEDNVVT
AITPHTDMGQGALSTMAQMLADEMDADWDKMNVMSAPANGDYVSGEMARHFVAPGLDLGE
LLEPTIDGAFQLLAGSMDLYLTGGSFSVRSTGQKGMRVAGAAAREMLIGAAADSWGVPAS
EITTEKSQLFHKASGKSATYAEFAVAASEQSVPAQPTLKSIDQFKLMGTPAPRLDIPSKV
DGTAMFGIDAKIPGQKMSYAAVLAAPVPGSKVATLDDAEARGMRGVTHVLNLGEFVAVVA
DSYWHAQQAINTVTATYTSAPTDNLDQAGMFKIFDAALNDAGDEGGDGLVDEGDVLDAFA
SAATKVEAEYQVPFLAHAAMEPINCTVWFHDGEAEVWIGTQSPLRCRSAAADVFGVSTDD
VTVHLAHMGGGFGRRSDANMVTMASRIAKEVDAPIKMIWSREEDTQKSAYRNATTSRFKA
GLDETGKPLSWDNIFLFHNDPADAAYVPYYDIASQRIRAVNDVELPLPFWAWRSVDHSQH
GFFVESFVDEMAHAAGKDPLEFRMSMLGNSPRFAAVLKKAGEMSGWGSATAANHGRGVAL
VRSFNTIVAMVADVDMSSGSPLVKKVYCCADPGYAMNPDGFAAQMEGGIIYGLTAALYGD
ITIRNGAVEQSNFHDYQMLRMYESPEIVVEIINGNPDDIGGGGEPGTPPIGPAVANAVFN
ATGIRPRKLPLAGQSYSV
>A0A7W7EVE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium taihuense|TrEMBL
MSTIVVNGQQRKVKASPDTPLLYVLRNELGVMGVKFGCGLAQCGACSVLLGDEEVRACVT
PISALEGKPVTTVDGLPQRWASQKGKMSAGTLHPVQQAWIDEQVPQCGICQFGMMIKVTE
LLEANPKPTDQDIREALTTSGPSPHLCRCGSYAAILEGAHRAAKLMMQGESA
>F4L4N2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MAVYNLNVNGKKVTVDVEPDMPLLWVIRDFAGLKGTKFGCGMALCGACTIHLNGQPVRSC
QTPVSSLAKNAKITTIEGISDGVQLHAVQQAWIEEQVPQCGYCQSGQIMSAMALLKTTPD
PSDADIDNAMSGNLCRCGTYDRIRKAIHRAADLSKTSSNSTQKVGGK
>F4L2R1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MAVFNLTINGKKHQVDVDPTTPILWVLRDHLNLVGTKYGCGMAMCGACTIHLDGVAMRSC
SLPVAQVSNQKITTIEGLSENGDHPLQKAWLEHDVPQCGYCQTGQIMSAAALLKDNPKPS
DEEIDAAMHGNICRCGTYIRIKAAIKTAARS
>A0A6M4H360|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MIPISVNGKAQKLDVEEEMPLLWALRDELKLMGTKYGCGIAQCGACTVHVDGEPVRSCIT
PCGSVAGKKVLTIEGLSKPGLHKVQKAWIEHAVPQCGYCQAGMMMAAVALLKKHPNPTDA
QIDEAMTNLCRCGTYARVRKAIHSVAAGGKPAAQKA
>A0A238U9X3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tenacibaculum jejuense|TrEMBL
MPTYNLKINGELVTFTADSDTPLLWILRDELNLVGTKFGCGIAQCGACTVHVDGVATRSC
QLQVSILDKEEITTIEGLSKEGDHPLQEAWKEVDVPQCGYCQAGQIMTAASFLKENPNPT
STEIREAMHGNICRCASYNRIEKAVAVAAKKMS
>A0A6M4GX11|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MIKFFVNGDPVQFNASPDTPLLWVIRDSIGLTGTKFGCGMAQCGACTVHVNGEATRSCIT
PASAVAGKRINTIEGLPDTPVTKAVRAAWLDKDVVQCGYCQPGQIMSATALLAKNPKPSD
ADIDAAMDGNLCRCGTYQRIREAVKTAAAALPAKK
>A0A087PNF3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MTILTSSRRGFLTGAAGLIVAVTARGHLAHAADAESTDFAPNAFVRVDRQGMISVVSPFL
EMGQGSFTGIATLVAEEMDADWSKVQVIPAEIGNKDYINPTLAKHGMPFQGTGGSSSLLG
AWQNMRKAGAAARALFISAAAQSWGVPPESLTVSNGIVSHFPSDRHAAFGDLVDRASKLP
VPQDVPLKDPKDYKLVGREQILPRVDVAAKVDGSAIYTQDIKLPGMLVAVIAHPPTWGST
LRHVDDRAAKAIPGVIAVVTVPGDKDILGGVAVLAKNTWIARQGRDVLKIEWDNTHAFSL
DTKALFTTYRDLSKRPGVVVTSRGTVQTSAPDGGHMIEATYEQPYLSHAAMEPMNCLVKL
GEQSCEVWNGEQFQTLDQMMIAKELGLKPEQVTINQLYAGGSFGRRANPRADYLRETVRI
AVAAKAAGVEAPVKLVWMREDDMRGGQYRPMTVHRAQLALDGKGRITSWHHVIVGQTFVP
SPPEKVDRILTEGLPDLPYDIPNFKVEQHIATEAAVPTQWLRSVGHTHSAFACESLIDDA
ARLTKQDPYQFRRSMLGKSPRHLAVLDLAARAYGWDRPLKPGRNGERRGRGITVWQSFGT
YLSEVAEVTVHTDGSFTVDRVVCAVDCGRPVNPDIIRAQIEGGVGFGLSFLNHAITLRNG
RVEQGNFNDYPVLRMNGMPKVEVHIMPSEETPSGVGEPGVPPIAPAVGNAIAAATGQPQR
TLPIGTLDLRSA
>A0A2A5RAJ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIESDEVGKRVVSTWVDLQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHAAVHELAGKGDA
>A0A375GT61|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLEMSGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A423L306|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQNVTTIDNLHADPVGQVVQQAWLDSAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A1E7DF65|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alteromonas macleodii|TrEMBL
MIEFTLNGKRVQTDAASDTPLVWVIRDEFGLKGTKFGCGVAMCGACTVHIDGNAIRSCSY
PVSLAKDKNVNTIESFNNAHPLQSAWVEEQVPQCGYCQSGQIMQAATLLDRNPNPSDQDI
VNHMSTNYCRCMAYARIKKAIKRAATSSVQYFDPTASSEGENA
>Q096G2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stigmatella aurantiaca (strain DW4/3-1)|TrEMBL
MTIRVRINGVDQELDVDPEMPLLWALRDVLGLTGTKYGCGQALCGACTVHLDGQVVRACV
TPVRRAADRSVTTIEGLSKDGSHPLQRAWVDLGVPQCGFCQAGQLMSAAALLAEKPKPTN
AEIDQSLAGNLCRCGTYTRIRAAVKKAAGLPEEG
>A0A5S9PFR2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania aliphaticivorans|TrEMBL
MKSVNNVQQLSRRDFLKFTGIAGSGLILATTLPLGNVAFASEAEGQQAFNLFVSIATNGR
CFIICHRSEMGQGIRTGIPQIIAEELCADWANVEVVQGLANEQYGSQNTDGSRSIRNNYQ
RLREMGAAARTMLEQAAATIWSVELSSVYADQGYVIHNASQKKLGFGELAEAAAKLSAPD
PSTLTFKNPKDFTFIGQAMASVDLEQMVNGEAVFGQDVVIPNMVYASIERSPVTGGKVLS
FDKQAALKIAGVIKVIKMPEQSLPALFKPINGVAVIASNTWAALKGRKALNVQWELGQHA
SHDSASYLNELRERITSPGKIERSKGDAYQALDNAAVKIDATYTVPYLAHAPMEPPAATA
SYKEGFCEVWTSVQTPQRAQKVVAEALGLNTEQVKINVTFLGGGFGRKSKPDFAVEAAIL
AKGMARPVKVTWSREDEIRQGYYHAISAQYYSAGFDQNKQLTSWVQRTAFPSISWTYTGQ
TDEPQAGELGLGFIDVPLAVENLSCETHKAKAHVRIGWLRSVCNIQHGFAIGSFVDEVAA
ASGKSTHQTWLDLLGNERYSDTENQGFEFLNYGESVDEFPLDVSRLKQVLNLVVEKSGAT
SQAKGNEAWGISVHRSFVAYVAVATKVRVVDNKVTVLEMHNVIDAGRVINPDRVAAQMEG
AMIFGLSLALMGEIAFKSGAVEQSNYHDYPLLKMPQSPYIKTYIIESTEPPAGVGEPGVP
PVAASLANAIFHATGTRIRDLPINKHFGV
>A0A2N7WBJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia rhynchosiae|TrEMBL
MGSLNINGRAVAVQAEPDMPLLWVLRCELGMTGTKFGCGVGICGACTVHLNDKACLSCQT
PMSSLNTQKITTIEGMQGTEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKQKPNPTDA
DIDAAMSNIVCRCGTYPRVRAAIHQAAKRRPA
>A0A484XFW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPET
PAGWRALAFNGHVDLGTGIRTSLAQIVAEELEVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAAYWQVSAAALRARAGRIVFADGADPRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGALTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREV
PPAPDLGDLEAALRANRAEPRHLRDDGNAAHALATTPAARRLRRSYVWPYQMHASIGPSC
AVADHADGRLTVWSGTQNPHMLRVDLNRLLELGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLVDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGSVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGGDGLLRG
RGVAYARYIHSKFPGFGAAWAAWVVDLRVDPASGHITLDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDSQGVASREWGAYPILDFTRLPDIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRKALLARKQPGMPRADAPLSDTQPA
>A0A0G9MK85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantiacibacter gangjinensis|TrEMBL
MPAMTVNDRPLEFEMDPETPLLFALRDAANLTGTKYGCGVGDCGACMVLVDGEALRSCLV
TIAEAEGRFITTIEGLSRDRSHPVQQALVAEQAIQCGFCTPGIAIAAAALIQRNPDPSEQ
DVRDAIPNLCRCGVYPRLVQAVQRAGRVARRRETISAAPAPGIEAEDAARAVPGMRGGTS
DGDGLGS
>A0A1E3EEC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MIKLKINGQEQNWDGDPDLSLLWYLRDEAGLTGTKFGCGQALCGACTVIIDKEAVRACIT
SVSDVVGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGYCQAGQIMQAAALLDQNPKPSHD
QIREAMAGNICRCGCYQRIENAVHLASTGV
>Q398Y4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MPTSFVLNGKNVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTVHLEGQAVRSCV
LPLAGIAGKHITTIEGLQSKPAHAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
ADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
>A0A3R9BLB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MVTLNINNRPAEIDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRAARSCTL
ALSAVGSARITTSEHLADDALGKAVLDAWLRHDVAQCGYCQSGQMMSAAALLRGNKAPTD
ADIDRAMAGNLCRCATYQRIRAAIHDAASALA
>A0A6J4UCM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Sphingosinicella sp|TrEMBL
ALYRQRPTGPVSYGSRNAPALGASGCVKSHRHQIWLRHGGLRRLHRQHRRQCGEELPGQD
RTARRQCRHDHRSAVARPLASGPASLGGRAGAAMRLLPVGHDHGRGRPARQEPGSHGRGH
RRRDHEHLPLRHLPSDSRSGAPRRPGQIRAGADRRRPSSGDRSGGCRPRRSVAAKRAAAG
AAGRADRGL
>A0A3G7HAT8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIETDAVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHSPAPSDA
QIDAAMVNLCRCGTYNAIHAAVHELAAQPAKKESA
>A0A2H5VS30|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR09|TrEMBL
MKGQGLNRRELLNLSVMVGGGLVLGRVWPALAEEPAALQPNPFVRVGTDGRVTIWVNKSE
MGQGVLTGLAQIIADELGADWSQVEAVQADADAKFGNQNTGGSTAVRTQFEELRKAGAAA
REMLVQAAAMRWGVPVERLIAKGGKVLDPKTGSSLAFRELVAEAAKLPVPQNPRLKDPKD
FDFIGKPLPRVDARAKLTGKATFGCDVRLPGMLFAVVARPEVFGAKLVSFEEKPALQVEG
VVKVVPVSSGVAVVARDTWAALKGRAALKVVWEPGEAASFSSKALLTTMEELAPKPGKEA
AKHGEGFLLPAGARKLEASFSLPFLAHAPMEPQNATAWFHDGGLEVWAPTQVPMPARQEA
ARVAGLPVEKVTLHVTFLGGGFGRRLSSDFVAEAVEVAKHFTVPVQLLWTREDDMTHDFY
RPPSVHFLQAAIAGKQILAWRHHQVTCSIGQQRNPSRAGQVDRGALEGAEPPYAIPHWLL
EQTLLPVPVPLGAWRSVYASQNPFASEHFFDLVARELQADPYQLRLKLLPEGPLKAALRL
AGEKAGWGKPLPAGWGRGVACCSSFGSHVAEVAEVSVRQGKLKVERVVVAIHCGRAINPR
LVEQQLVSAVVFGLSAFLRGRITVEGGKVLETNFDRYEPLRFHEMPRVEVHIVPSEEPPG
GVGEPGVPPLAPAVANAILAATGKAVNRLPWEA
>A0A0D1EMJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia aquimarina|TrEMBL
MTTFTLNGAEVSLDADPDTPLLWALRDHAGLTGTKFGCGVGACGACPVHLNGAAVPSCTL
PLAAVEGAEITTIEGLGGADDHPVQGAWIELDVVQCGYCQPGQIMATAAMIAQVPQPEAE
N
>A0A2S6RJ87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alphaproteobacteria bacterium MarineAlpha9_Bin1|TrEMBL
MLINLSRRDVLKGSAAAGGFILGAQIGAEGLLSSVSEAAGSLSNLYVIVNTDGSVVITCA
RSEMGQGVRTSLPMIVADELEADWDRCSVVQADAEQKWPDAGQELDTDGSRSVRRDLKRL
RTAGAAARMMLEQAAAQKWGVPASEISSQNHTVTHTASGRSADYGELAGIAAGITAPKDE
EVRLKNRAEWKYIGNESAYTPDRYVDLADMTTGKGIYGADVILPGMKTAVIARSPVYRGT
PGSVDDSAAKKISGVRGTVEIPTPELPIAVKPLGGIAVIADNTHAAIEGRKALKIKWNKG
GNEGHNSSSYEGALRTAARNPGTVLRNRGNVDAYFNRSGRIFEREYYVPYFIHTPMEPPA
AVADFKNGKCEIWACTQHPLWIRDTAAEVLGIDKENIQVHVTLLGAGFGRKSKADFAVEA
AYLSKETGHPVRVIWTREDEIQNGYYHAASAQHIKAGVINDKVVAWRQGVAFPSILGLWV
PDQKIGFNIEHGLGYVDMPYNAIPNIRMENGDADIHTRVGWYRSVNNIQHAFAMNSFVHE
LAHTLGKDPVQFQLDLIGPPAIIDLSAEGVSDYWNYGDPIDVYPVDTGRLGNVLRKAAAI
SGWGKRQFPKGHGLGLAVHRSFLSYIATAVHVAVAEDGTYTIPRIDTVLDCGMAANPERV
RAQCEGANVYGNTIARHGLISFTNGSVDQSNFHDYPISRMNDSPLNVHLHLEETSDVPSG
AGEPMVPPFAPALANAIFNATGTRIRNLPITPADVLKG
>M1WPK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudodesulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30)|TrEMBL
MTENITRRNFLKKSFLVLAVAATPGAMALMNLSPAFAKDATPFKPHAFLEIAPDGGITIW
VGQTNLGQGTHTGIAMIIADELDADWADVKVRMALASDAFKDPLWGIQLTAGSTSIRNRW
DLLRTVGAAARLMLIQAAATKWGIPAQDCTARSGKIVAPDGRILGYGELTEEAAKLDIPA
KPAFKTVDEYSIMGTYRQRLDMEDKVQGRTIFGLDIQIPDMLIAVLARPPRYGATPESFD
EKAAMAVKGVEKVLPLDDKVAVFATTTYAAIKGRDALAVQWSRGSHPDLNDASIAALFRQ
KMASPGAIAEALGDTEKALSGAAATVEAAYSVPWVAHAQLEPNNCTAHVEADRCRIWAPT
QGQTAALDAAREVTGLPLSKIELMTTYCGGGFGRRIEADYVTEAVALSKAANRPVKVMWT
REDDFADDVYRPASTCEIKGGLDADGNLVAWRHKIASQSIFSRVQPDSVKDGIDSSSLQG
LPDMPYSLPNRLIEYSLIDLPMRVGWFRSVAYSYNTFFVESFMDELALKAGKDPVEFRLA
RLEKGSRPYNALMTLTEKGGWESPLPANRGRGVALCSCFESVAAHMAEVSVDPVNGQVTV
HRLVAVVDCGTSVYPDGITAQMEGGAVIGMSLAFNEAMRFADGGVGTYNYSDYPLLSMTQ
VPEIEIFIEDSGAKAGGIGEPSVPSVAPAIANAIFAATGIRLRDLPFKTDILKKTDASMS
>A0A2R8B4I7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Defluviimonas aquaemixtae|TrEMBL
MFALPGKLNFVLPAIKPTRRGFLLGAAAVAGGFSVGFRPDPASAQSADAQASPFGAYVTI
TGDDQVTVISSQFDMGQGSYNGLATLVAEELGARWDQIDVVGGAGNPALYGNLAWGGAAQ
GSGGSTSMFSSWDRYRTAGAAARLMLVAAAAEAWDVPAEEITVADGMLSHATAGAARFGE
MAARAAEMPIPSEIALKEPGEWTMIGNPDLRRYDSAAKTNGTHDFTIDVKLPGMLTAVMI
HPPKFGATVKSFDAEAAKAMPGVVDVVETPRGLAVIGEHMWAAMKGREAVTADWDESAAE
TRGSEEILAEYRALIAEPPAAIARQEGDSAGAIAGAAKVIAAEYEFPYLAHAALEPLNAV
ARMGEDGVVEVWGGHQVPDLYQFIASQVAETTPDKVRLHVMKTGGGFGRRAVADADIVVE
AVAAARAIGWRAPVKVQWTRDNDMRGGRYRPAYAHAIRAGLDDAGNITGWEHHIVGQSIV
AGGPFEGLIQNGVDPTSVEGASHLPYALPNQTVGLTTANVGVPVLWWRSVGSTHTAFAVE
TFLDELAEAAGKDPLEFRLALLGNAPRHAAVLRLAAEKAGWGTPPPEGRVRGLALAESFS
SYVAQVAEISVDGGNVRVHKVVCAVDCGIAVNPDNIRAQMEGGIGFGLGAIMAEELTLVG
GEVQDTNYDTYTPLRIDAMPEIEVHIVASGEPPTGVGEPGVPPIGPAVANAIYAATGKRV
RRLPIEKALRA
>A0A0M6XMD1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia rubra|TrEMBL
MTRARTVARRGFLIGSAAILGGVAFGVVAWKRDPENPLLAHLPEGTRTLNPHVLIDAAGV
TLITPRADVGQGAVSIQTYLLAEELDVDPATVRTDFGPASAAYYNARIAAEGMPFAAWDD
GLTARAARGAGDAAAKFIGLHITGGSTTVADAFDRLRAAGASARETLKQAAADRLGVERD
ALRTEDGAVMPPEGPPIPYADLAEDAARLTPIRVAPRDPAKWRWLGQPVQRTDIVAKSTG
TFRFGTDIVLPGMIHATVVTNPAMGGGVRSLDDRAARAMRGVQDVLPVAGGFAVLADNTW
RAMRAARAVAVDWGEAPGRAMDTDVIRQAHADTFTSDNRDSRFADDGDVDAAPAGDAEAV
HAEYRAPFLHHAPMEPANATVLHDDTGTQVWTATQVPVFLRDAVAKLTGQDAERVTIHNI
ASGGSFGHRLEFPWVLQAVEVAMQVSGRPLRMTWSREQDMTHGFLRPMAVARGQGTVGQG
RVRSFDLSIAAQSVTESQIGRLGLPAIGPDVTIVAGAWDAPYAIPNRRVTGYRVPAIVGV
SSWRSVGASHNGFFVETLMDELIHRAGADPVEERLRLIHHAPSRKVVETVAGMASWTGPA
PRPGIGRGIAFTYSFGVPCAQIVEVSDTPDGLRIDRLWIAAEVGRILDPVNLEAQLSGGA
LFGMGHAMMAGITFDRGAIEQTNFHDYESLRLRQVPQVEVRALGTTGDIRGASEPAVPPA
APALANAIFAATGTRLREMPFSKTLRFA
>A0A7W8BK42|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces albaduncus|TrEMBL
MLAAPVLTAAAELVPAAEARAQTPSSDTPSPQIPSPEITELVDLNDVMTAAALPTSGLIT
VEVNLDGTVSFALPRAEVGQGITTSTAMLIAEELTVPLDRVRVTLADARPELLFNQLTGG
SNTTFSTYTPIRVAAAVARGRLLRAAATAWGVDVTELVLKDGTVTGPGGRRVGIGALSEK
AASVRTRQVSVDLKPRDEFTVIGTPHNRVDALAAVTGRKTFTMDLAVPDALPTMVCRPPT
INGKVGSVSNAAEVRTMPGVTDVAVVSTGVAVRAATFGQCIDAVRALRVSWKPGSAEGKS
DESVLRTLRAAELPLGPPPLTPSVEGTFTFHFRSNSALEPNCAIADVRPDRAEVWSCLKA
PIVAKEAIAAKLGLPLGAVTVHVTEGGGSFGRRLFFDAALEAVEISRKIRKPVKLMWHRA
DDSRQGRTHPMATSRVRIAYLGDTVLSYRQRHTGVATDLSHGLGEIFTALAAKLPVGDIG
FSETFFQLSQSMPYDFGVNSRLLSETDKSFNTGSMRNVYSPDVTCARELLVDRLAARMDK
DPYRFRHDFLRDDRARAVLDKVAEAGRWGRTMPPGTAQGIAFHSEYHSVNAVLVEIDCRP
ETVDRPIRDGVGGPRVTKAVIAVDVGLAVNPRGLEAQMMGCLMDGIALTLTSSLHLRDGY
FLEASWDNYFYTRQWNTPPELDIIVMPPTTGKPGGAGELGVAASMAAVACAYGRATGTMP
TSFPINHGTLSFEPKPTVPPVPASPADGLDHVR
>A0A1V0PUW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MSRIGKIARRTFLIGSATVTGGFAVGYYAYRKPPKNPLPTDPAGDAVALTPYVLIDGSGV
TLITPRAEMGQGAMTVQAALLAEEMDIAWADIRTDPGPPAAAYYNAYVVANGAAAATDEV
WQADLKRTFGTGISKVMGLQITGGSSTVPDSYDRLRRAGATARAMLVAAAAKRLGVDTDK
LRTEDGAVLAPDGTRLPYPDLAAEAAGITPPRAVALKDQADWRYLGRRIDRLDIVAKSTG
TAQYGLDQTAPGMVFASVRTNPHRGGGMTGFDASAAEGTPGVLKVVPITDGAGVIATNTW
AAIEGAKAIAFDWGAAPAPADSAGLWDAIAASFAEETRDHRLKDDGDVEAALAAGIDVAA
EYRVPFLAHAPLEPMTAFAWLKDGHLDIRAGTQIPRFSLKKAARISGLPEDAITLTVLTM
GGSFGRRLEDDFIAQVVELAMAMEGTPVKLIWAREEDMTHDFPRPAAIARGRGRVADGQV
QAFDLSIAAPSVRASQMGRLGLSTGGADSTITEGAWDQPFAIPHYRVTGYRTPPVVPVSS
WRSVGASGNAFLHECMLDELIHAAGADPLAERLRLCTHPLSARVLETVGEMSGWGTPLEP
GRGRGLAYCLSFGVPCAEVVEVTATDRGIRIDRVFAVAEVGRVLDPVNIENQMQGGVIWG
LSHAIHAELTYADGRPDQENFDTYPALRITECPDITVRALENGDQIRGIGEPTVPPAAPA
LANAIFAATGRRIRALPLNKAVDFVG
>A0A6J4S0P1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Segetibacter sp|TrEMBL
MLLAEELDVDWKNVIAEQADFNANVMNASLQEGVHLYKLPGNRCVLQGLQPG
>A0A7G6VA65|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MRIRTAGRPASTDAPHPDASPVAGTGSPSLGRRGFLKLTMAASGCLALGFAPNRATAEAG
KALPSSPPQAFLIIAPDNTVTIAVNRTESGQGVSTALPMALADELDADWRNVRTVLAPAG
EPYKDPVTGIQMTGGATSVNHSFAQYRELGASARAMLVAAAARRWNVDPAACRTANGVVT
AGNRSATYGELAPDAMAMPVPQRVPLKSPDQFRIIGKPTPRIDARAMLDGTLKYGMDWRL
PDMKVAVVARPPRFGGQVASYNAAAARAVKGVVEVVEIPVDRGGTGVAVIADGYWPAKLG
RDALQVTWKDSGSSVSSAEQIRAYKQLAASPGTVVRTASSGSAPPPATRIQKDYEFPYLA
HAPMEPLSCTVDVGPASCACGIKIWGGSSLQTADRAAVAKALGVAPAKVQIFTLTSGGDY
GRRSTPTSDYVVEAARVSAAYLAAGHLGPVKTIWTREDDLRGGYYRPMVLHRVDIGVDGS
GTVRDWQHVVVGQSVLKGSPLERTTIRKGGVDPALTEGVADSPYGFPMQVSVHQTDADVP
VQSWRSGGHTHTAFVMETLVDELAHAARQDPVAYRMARLSGPEHAPHRQALALAVDKSGY
GTRTLPAGHAWGTAMHESAGTVVAYVTEVSIEAQQPRVHRVTAGVYAGRIVNPTGAEAQI
QGGALFGLATTKPGFAIDVDHGAVRNAGFADYPPVRMQEAPPVDVFFVPSDAHPTGLSDA
GVPPIAPAVANGAFVLTGERMHALPFAPMLVAAAAPAMPTAPAAAVDDDPYGDLPAGGCR
MPRKVKPAALKPRTDQSHAGVGQAPSVPKFLRPKRRAGIPCIDDLKKGTV
>J2Y679|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens Q2-87|TrEMBL
MITLKLNGKDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVKGQDISTIDALHADPVGQIVQKAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKIAIRQASTHLKEAKA
>A0A0M2WDQ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. KBS0711|TrEMBL
MTTLTINGKQHDLALPEDTPLLWALRDELGMTGTKFGCGMALCGACTVHLDGEAIRSCVT
PMSAAAGKKITTIEAVGEDKVGLALQQAWQEHGVPQCGYCQAGQIMSATALLHKTPKPND
QQIREAMSGNICRCGTYTRIHAAIKQAATSINAKGAAK
>A0A5E4TFR9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea fibrosis|TrEMBL
MRGLRFSQRPGVAVGDFAGVSRRAFLKTSAMAAGGLMLEMSLPGAMRSASAQGAAATPVV
PSAFVRIAPDDTVTIQVNRLDFGQGVQTALPMLVAEELDCDWSKVRSELAPAADVYKDPL
FGIQMTGGSGSVAHSWLQYRRIGASARAMLIAAAAQQWKVPASQLRTENGVVLGPNRQRA
TYGSLAARAQALPVPADVALKDPSAFRLLGKPTGRLDARAKSTGVPMYGMDFKLPNLKVA
VVARPPVFGAKVKSFDAKAARAIKGVRDVLEIPDDRGGTAVAVIADGYWQAKTGRDALNA
TWDTSGVEHVDTTAQLAKFKEMAKTPGTVAIDADISKLKGAPKTLVAEYSFPYLAHAPME
PLNCTVQLTDKGAEVWTGTQFQTVDQAAMARTLDLKPEQVKLHTLMAGGGFGRRAVPTSD
YGVEAAQVAKAWRRAGHREPVKVIWSREDDIHGGYYRPMYVHRAEIGLDAKGNVLAWNHT
IVGQSILQGTPFEKMMVKNGIDATSVEGVSGTPYAVPLRLTLHSPQVNVPVLWWRSVGNT
HTAFVMETLVDELAKNAGQDPVAYRYALMGDKHPRHREALALAVERSGYGKTKLPQGQAW
GVAVHESFDSVVAYVVVAEMRNGSPRLVSATAGVHCNFAVNPLTVAAQVEGAALMGLGTT
LPGAAITLKDGAVEQSNFHQYTVARLTDMPAISVHVVSSGDAPTGMGEPGLPPLAPAYAN
ALFALTGKRQRALPFEVTQA
>A0A7Y9SWP1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis sp. JAI108|TrEMBL
MAGIRDTVGKDKSRRPHVSRRQMLIGATAAGGLAIAWSLWPRDYQPNLTAAPDEHVFNAF
LKIGDDGHVSAVVPQCEMGQGVTTLLPQIMADELGADWRTIAVETAPISPLYANTLLVDE
DSATFTPRSGVPDFVSDVRSWARREWAVRHAVMLTANSSSVRMFEGPCRAAAAQARALLM
MAAAERWDADWQECDTQDGFVIHGKKRLRFGEVAAAAALLDPPAEPVYRAHSPDPLYGKE
LTRLDLPAKIDGSANYAGDIRLPDMVFAAIRQGPLGATRLKSIDRKAGMAAPGLLHVVTH
DRWVATVARNWWAANRALDRFAPVFETEGTPVSSDGIDAALKAALKDDGYRIASEGDVAG
AMDGRKPIAAEYAVAPALHAAVETRTATAAPDRDGLRLWVATQAPAQCRDAVARATGLAA
ANVTLFPMMAGGSFDACLDHSVAVQAAIVALQIKRPVQLAWSRAEEIMRLPPRAPARAKL
TATLNAAGGIDALVTRIAVPATNHEVRARLFENIPADEAQRAAAGRADAAAVEGAMTRYA
IPHRAVDHCPADIGLPTGRWRGNADSYTAFFTECFIDEMAARAGSDALSYRMAMLGNAPL
LARCLLTATSLGGWEGGLSGSAQGLACHSMRGSHIALMATARQSDRGLQVEQLVAVVDAG
RLVNPAIARQQVEGGLIFGLAAAVGATTDYEGGVATARKLGQLGLPRLSQTPRILVEFVE
SDREPGGLGEVGVPVVAPALANAMFAATGRRIRRIPLSAHPL
>A0A1A9GI26|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides dokdonensis FR1436|TrEMBL
MTASPDAGTNQPPPAADGPAPGVARRSFLGYVIGGTTLVAAADLAMARPARAAAVPSLPQ
VPELYDLEDLQSDAALPTSQLITIEVHEDGTASFALPRMEVGQGITTSTAMIIAEELDLP
VDKVRVSLAPARPELVFNQLTGGSNSTVSTYTPIRVAAAIARGALLEAAALQLGYAVERL
TSKDGVVLGPGGEALSYGALAGAAASPTTKQVDVQLKEPGQFTRIGRARNRDDARLAVTG
QKEFTLDLEVPGALPTMLCRPPTLNGSPKKLRNTKKILRMPGVKNVAVVDTGVAVRAKTF
GQCIDAIRAMDVVWNPGPVEGESDQTIMARLKKAELPLAVPAVPLLAETVEERFEFMFRS
SAALEPNCAIADVRADSAEIWAGLKVPILAQQNIAQELGMSQDQVQVNVITGGGSFGHKL
FSDAAIEAAKVSQAMGKPVKLMWHRADEPRQGRLHPMVTSRIRATVLAGEVLTFEQRNTS
VVTDFSHGLGEIITSTIDEAPTEVGRRLGGMGFSQTIFTLTQELGYNFGAVTQLLNETDD
RFNTGSMRNIYSPDTRVAVELVVDRLAAKVGLDPLEFRLKHAKSPKVRKALEKVAEEGDW
GRKMPQGMAQGISIHQEYKGATACLVEIDVRPETVNRTIRNAVTGPRVTRATFAVDAGLV
INPRGLQAQMMGGFSDGLALTLTSSVHLRDGHFIEASWDNYYYTRQWNIPPRFDCFVLPS
DDQLPGGAGEAGVAASAAAVACAYTRATGTMPTRFPINHGRVTFKPKSFVPSVPKSPTNG
LKFTY
>A0A518BDF1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Planctomycetes bacterium Pla133|TrEMBL
MPKLTINGEPVELTDLDPRTPLLWVLRDSLNLTGTKFGCGIAQCGACTVHVNGTAMRSCS
VAIGSLEGREVTTIEGLSPDGSHPVQKAWAQMNVPQCGYCQTGQIMSAAALIASNPEPDD
DAIDSFMGGNICRCGTYPRIRAAILSAAQEARQ
>A0A1R3UKA1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardiopsis sp. JB363|TrEMBL
MAQQRRNGEIESMSEPGASPVPRPGAHVVARRRFLGYVLAGATLVTAAAPVLPAAAEAED
AQTADLTDIVDLNDVMTLAGKPTSLSITVEVHDDGTVSFALPRAEVGQGITTSTAMLIAE
EMDLPLDRVRVTLADARPELLFNQLTGASNTTISTYTPIRVAAAAARLRLMEAAADEFGS
EVGALTLRDGVISDESGHSADIGTLAAKAASETDEEVDVELKSAQAFNDVGEPQNRIDAL
EAVTGRKKFAMDLAVENALPTMVCRAPTINGTPASVANADTVLEMAGVTDVATISTGVAV
RARTFGQCIDAVRALEVSWASGSADGLSDADVLRELEGAEPRMPLPLPGVSRLEEKFTFH
FRNNSALESNCAIADVRSDSAEIWSGLKSPIVAQGEIAKLLGLRQSAVTVHVTESGGSFG
RKLFFDAALEAAEASKAFGKPVKLMWHRADDTRQGRTQPMAISRVRISHTRNRVLRYDQR
HTSVATDLSHGFGDVVTAMAAQVPGLDGTFSQVFFQLSQATSYDFGLSTRLLNETNRSFN
TGSMRNVYSPNVLTTRELMVDRLAREWDRDPYELRRDFLDDERSRAVLDKVAEVGEWGRE
MPEDTAQGIAFMHEYKSVCAVLVEIDCRPETIERPIRNGVAGPRVTKAVCAVDVGLAVNP
RGLEAQMQGGIMDGIALALTSGLHLEDGHFLEASWDNYFYTRQWNTPPEMEVVVMPANGE
PGGAGELAVAPANAAVACAYGRATGTMPTTFPINHGDLSFDPIPTEPPIPESPTDGLDDA
V
>A0A1E7W8Q3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella phyllosphaerae|TrEMBL
MSKVSRRRFLFGGVAAMGALVVGWGVLPARQRLHGSVSLPLTGGALALNGWVAVAPDGAV
TIAMPRSEMGQGVHTALPMLVAEEMDVPLASVRLVQAPLDAIFGNIAMLQDGLPFHPDDD
GALKAGARWIVGKVARELGISITGGSSSVKDAWLPMREAGAAARAMLVAAAAGQWRADAA
DCRTEDGHVLHRDGRKLAYGALAAAAVTSQPGEVRLKTPQQFKLIGRAQPRRDTPSKVDG
SAVFGIDVRVPGMVYAAVRMAPVIGGAVATVDTSVALKMPGVLRVVDFSRALGHLAGAGA
GVAVVARSWWQARQAALALVITWRDGANAGLSSEQVFDHFAATLDKEDGHAYHQVGDMDS
VEGKGAGVARAIGAEYRAPYLAHAAMEPINCTAQVNVRDGKVHLWAPTQSPGFAVKAAAQ
AAGVAPAAVTLEVTMLGGGFGRRLDVDMVAQAVAIARAMEGVPVQTIWSREDDMGHDVYR
PAALARFAATLDAAGHVLGYDCKSASGSVSHQFFKRNLGLPAAGPDKTTAEGAFDMPYEL
PNQRIRHVIVESAVPLGYWRSVGHSHNAFFKESFIDELAHAAGRDEVAFRRALLAHHPRH
LAVLDAAVARAGAAPAGRAHGVALHQSFGTIVAQVAQVSVAGTEIRVHRVVCAIDCGLAV
NPNIIAQQAESGVVFGLSAALFGAVTIKDGKVEQSNFHDYPVARLNQAPEVETIIMPSAA
HPEGMGEPAVPPIAPAVANAVFKLTGKRLRSLPLSLSS
>A0A1Y1J0A6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Comamonas testosteroni|TrEMBL
MQTPLRCAWLLAAGITASLTLHAQESKLTIGASLPLSGSQAEAGKEGMSIMQAQVEAFNK
QGGLDGKALTLKVLDDGYEPQRAASNARQLIQEGALALLNCWGTASCTAMQPEVQQGQTA
LVGVIAGAGSVRQQPGRFIYPLRASTQAEVAAMLQQMQTIGLRRIAIVHQNDSFGKSSLQ
IALNAFAANDLKAAATLAVEASGSNAPDLARQLAALPDLQGVIMLAGAPATIGLITMARQ
AHVTAPFYNLAAQANRAVVQGLGPYTRGIAFTTLVPSPWKGAIPAIKDYQQLVGQPGMPP
ASYLGLEVFLNTRTLLDALRKATPSNQRASLTAALDAMGEIRYGAMHLRFTPPRTGSSYV
GLTMIDASGHFRE
>A0A0F7M5Y6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Spongiibacter sp. IMCC21906|TrEMBL
MSNIEITLNGEARQLSVEDGTPLLWVLREQLAMMGTKFGCGVGLCGACTVHLDGNPVRSC
SYPAQLANGRKVTTIEGLAPSDEELHPVQQAWLEMNTPQCGYCQSGQIMSAAALLANNNS
PDDSEIDAAMSGNLCRCGTYPRIRKAIHRAAALIATDQADAPAEESQA
>A0A0F7M2F3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Spongiibacter sp. IMCC21906|TrEMBL
MMQRRQFLKTTALLGGGVAIGFHLTGCDQAPYPGSADDVRPNAFLQLNSTGEIVLQLHKS
EMGQGVYTAMATLAAEEIGIHPSELKIEHAQFHPEFRDPSFKVMITGGSSSLSTSFLPLR
EAGAVMGALLRHAASYQLGVKQERLTLQNGMAVFEDKKVSFAELLPVARKLPMPSDVALR
SASDFRYIGKFDQRLDSRDKVTGKAMFGLDSSYPDALTAVLVRCPHSGGSLKKFDAKEAK
DKPGVESIFEIDGKIAVVAKGYWQARQAANIIDVEWNKGPFEGLSQSDLLTRRKALLDSE
DRRKAEEIGDETLFAGDDYSAEYQAPYLAHATMEPMNALAAVTQNGLEIWTGIQAIDLAR
NAIADATGFTPEEITIHNTMLGGGFGRRLTPDYMVEAAQLAVHLKKPVKLIWSREDDMRH
DFYRPAAMARMSAKLSGNKVNGIYSELVAPSIFKGFLPMVTNTLLPNWVPDKAHRYLGDM
ASGYDPSATEGVIKSPYQFPYARTDYIEEPSPVQVGYWRSVGHSQNAFFMESFVDELAHQ
AEQDPLDFRLRLLPPDSPYRAVLKLAAEKAGWGNPQEGRYQGLAFHESFGTPVAQVVDVS
IEHGQIRVHKVVCVLDCGLAVNPDIVKMQMESGIVFGLTAALKGEISFQDGAVQQSNFHN
YELLRLFETPEIEVYRIDSQASPSGVGEPGVPPIAAAVANAVFVATGQRLRSLPLRLAAS
>A0A653JQK4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus sp. 109|TrEMBL
MIKLNVNGQPREVDADPATPLLWIIRENLKMPGTKFGCGIAQCGACTVHLDGKPVRSCST
SLSAAEGKTIATIEGLASEDGTLHKVQQAWIEAQVPQCGYCQSGQIMSAVALLEKNPRPT
DAQIDEAMAGNVCRCGMYGRIRRAIKAAADIDQPAQVEA
>A0A165PFI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. Ad26|TrEMBL
MYPKIPLTVNGQKQEIEADPEMPLLWALRDIMDIKGPKFGCGIAACGACTVLIDGEAVRS
CSQPVGEVEGEITTIEGISQGGELHAVQQAWMKHSVPQCGYCQSGQIMAAVALLEENPDP
TDEDISDAMTNLCRCGTYPKIKAAIKDAAQTLGA
>A0A3S4DF47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera|TrEMBL
MTKVSDSHDREAFPTGEPVNISRRRFLLGAAGTMAGALVLGFGLPVRQVRAQTPGNHAAP
GTHVPAFLEIRPDNTIRLQSPFIEGGQGIFTGMAQIVGEELDAEPMSFIVENAPPDAEYT
VMENGLRITGGSMSVRMSYSTMRRLGALARHMLLQAAASQLGVPLDTLTTEPGRVIHQGF
RPVSALWATRAAGQLAPRATRAAGNGTAGARCCQRDAQGSEPVPLDRETGTTSGRLR
>A0A2X2EI15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas luteola|TrEMBL
MTFLVSRRCFLQGLSALVVGFSFNGVRAAELLTPDLSAEQMQKTLDARQLDAWLAIRQDG
RVIIYSGKVELGTGVETALRQIVADELCVSFESTRLIQGDTQLTPNQGITAGSKTIQVGG
AQLRQAAASARHYLFNEGARRLGLDTSVLDTVDGCVVYRGDPTGRYVRYSDLLTQGAFER
SVDKTASVRAVESYRVVGQSIPRVDIPAKVFGQFRYVHDLTVPGMVHGRVIRPPITGASR
LDGLKVEHLDASELPAGAQLVYEGNFVGVVAEQEWVAMQAARALKVTWSYTSTLPNPGDL
YGRLRHVAGEPEVLVEQGDVIEHMGQAAQVISAEYRWPFQNHDSIGPSCAIADVRAGAAT
IWSGTQGIYPLRSALANLLGIDEHAVHVIYSQASGCYGHNGADDVAGDAALLSRHCGRPV
RVQWSRADEHGWNPKGPAMLMQLQGGMNESGDLVAWHFQNWTPTHVTRPSAKAGAASLLA
GQLSRGLAVQGPNAGGGRNAPTSYTLVNCRVETHWIDPLSSPLRPSALRGLGAVANTFAN
ESFMDELAWAVSVDPLAFRLRYLQDPRGRAVLEAATRQARWTPRQQGPDRWKGQSVQGRG
ISYVQYENENAYVAVVADVDVSSAGVRVRRVTVAHDCGLIINPDGVRNQIEGNVIQAIAR
TLKQEVTFNPTGVTSLEWGAYPVLAFHEVPEIDIVLLDQPDQPSVGAGEATSAAVPAAIA
NAVFDATGLRLRQVPLTRARLTSAMHA
>A0A7X0JUW7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoteredinibacter isoporae|TrEMBL
MQHTITEINNPNYVTDSLMIKFTLNQQAQAVEAEADMPLLWALRDILHMTGTKYGCGKGL
CGACTVHLDGAPIRSCLTPLSVVAGKSITTIEGLSEDGSHPVQEAWKDINVPQCGYCQPG
QMMSAAALLAYNAMPSDEDIDGAMSGNICRCGTYPRIKEAIKKAAKAGQEKTA
>A0A2J7VJJ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. B4|TrEMBL
MSMDIAPSIESTPLSRRQFLIRSSTVSCSVAFALTGAARTAVAAATQDAATTGKISPNIW
VNIHEDGVIEIVCPAVELGQGAHTALPRFVAEEMDADWGAVRVLQASANDKLYGNPLAWN
TQITAASRTTNGYFDVLRVAGAQARYILLHTAAGKWRVPFAELSSRKSVVLHAKSGRRIT
YGELVGSIQMPASLPHFFAPGEAPQPADDYFGEAPLSIVAPDPKRKDSIRLKRKYQYQLI
GVDTPRPDIPDKTTGKASYGMDVQLPGMLHAMVETGPVFGMAPEEVDEAQALQVPGIVRV
LRLPYGVAVVGDNLIAVRIARRKLQVQWAPLPEKQGYGSDAVLQEFSELARETKGTAVRA
WSQGDASATESALAAGARSSVERFEMTSDLVYQSPIEPQNATIRPSADGKSAEAWVGTQW
PTVEQGFAASILGIPPDQLKMHLPYVGGGFGRRLEPGAMVDAAHIVRAVGKTVKVLWTRE
DDIKRNPFRQALACRIEAAVDEKSGQISAMRHTVVADSWLARLFPQYFGAYQQTDPGNWI
GGRVAYDIPLQVIDAVTPRRSVDVCYMRGIGVAQVKFAQESLMDRLANQRKVDPIEFRVR
HLKKEPRAVAVLNEVARMSNWRRRRQTLSDRSTALGVAYTPYSNAHVALVSEVSLNSQTG
EIRVLRVWCALDIGLVAQPDIVKSQMEGGIVQGLSVALMERVTVERGVVQQTNFHNYPIL
RMSQMPDIAVTILATEHPMTGVAELGLLQIAPAINNAVAHLTGTHLTRLPMLPAQVLAAI
KSP
>H0S8A7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MTPATIRLTVNGQTHDVAAAPDTPLLNVLRNDLALNGPKYGCGLGECGACTVLIDGRAAR
SCVIPIEGCVGRTVVTLEGLGSREAPDPVQQAFIAEQAAQCGYCLNGMIMTTKALLAIKP
DPSLHEIKQALRYNLCRCGAHVEILRAAMRAAGHTLEALD
>A0A7W4VBI5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus alkaliphilus|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLSMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A2C9DDV3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hartmannibacter diazotrophicus|TrEMBL
MKLNLNDEIHDVQSDPDTPLLWVIRDELGLTGTKFGCGLAQCGACSVLVDGQITRSCVTP
LESVSDSKIMTIEAIENDDVGKRVVSAWVAYQVPQCGYCQSGQIMAATALLKETARPTEE
DIAAAMINLCRCGTYNAIKAAVNDVAGRKETSL
>D0I5P9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia hollisae CIP 101886|TrEMBL
MSVSVNINGQDYELEVPADTPLLWALRDNLMLTGTKFGCGIAQCGACTVHIGGQPIRSCV
TPVSAVAGQNITTIEGIESKAAKAIQAAWEDIQVPQCGYCQSGQIMAASALLTNNPAPTD
ADIDAAMNGNICRCATYVRIREAIKQAATELKQG
>A0A1Y5TJ99|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria litorea R37|TrEMBL
MTLNTSRRGFLKGAAAASTVLFVGMRPDGALAAGSSQSAMLNPFVKIDADGTVTAIVKHF
EKGQGPATGLTTLIAEELGISMEDIAYEFAPSDPGAYNNLLFGPVQGTGGSTAMANSYMQ
YRQAGAAAREMLIRAAATEWGVKASSLDIVDGQVTDGTKKAPLAQFVVAAAQVAVPENPT
LKDPSEFRLIGNANVQRKDTPPKINGTARYAMDLHLDNQMVAVILRSPRKGALATGFNDE
GAKGIKGYIRAAVLPNKAGVVVYAEHTWAAFQAREALSVDWDDTNAETRSSDEIREQLVA
AVNAEPTYVLTETSATKAQSSMDSAATVLEETFYFPLLAHAPMEPLTCTIEATADGGVIM
HDGCQFPTVPHGALSQILGLPMDKVQINTMFAGGSFGRRATPVADYQVEAALAFVLTDWS
RPVKLVWSREDDITGGFYRPAVAHRVRVGLNADGEILGWDHRIAAQSIMKGTPFEAMAVR
DGVDHSSVEGVTQSPYLIPQQHIGLTDVAPATTVLWWRSVGHTHTAYVVESMMDAAAKAA
GRDPVEFRLSYLSGDGADQKRMTGVLKLAAEKGNWGSPPEGRDQGIAVHKSFNSYVAEVV
EISRDEDGYVKVENVTCAVDCGIAVNPDVIKAQMEGGIGYGIGHVMRDEITLTEGVVDQS
NFPDYEPLRIGDIGSIDVHIVASNEAPTGVGEPGTPPSAPALANAIAVNGPRVTALPMIN
NGVDFV
>D8NGC5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum CMR15|TrEMBL
MRIRTLEALAGGGAHDPAAPVGADAGVAMLDRRSFLKLTALAGGGFALGVAPMLAGAQDA
AAKPPSPPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAG
DPYKDPLFGIQLTGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSACRTANGVVT
AGGHRATYGELAQAAMALPVPRQVALKNPSQFRIVGKPTPRLDARAKLDASLKFGIDTRL
PDMKVAVVARPPRFGGKVAKYDAAAAKAVKGVVDVVPIQTDRGGMGVAVIADGYWPAKQG
RDALQATWEDAGSRVSSAALMNEYKTLADQPGTVAKAADVGAIQSAAKRIRADYEFPYLA
HAPMEPLNCTIDLQSAGGKVSAAKVWVGSQFQTVDQGALAKALGIAPEKVELNTMMAGGG
FGRRAVPTSDYLVEAANVAKAYAAAGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKGTPFEPYMFKNGVDATMTEGVIENDYGFPMQVSVHHPDVEVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPVAYRLARFTDKEHARHRQALQLAVDKSGY
GKRKLPKGQAWGVAVHASFESVVAYVVEVSIDQGKPRVHRVTAGVHANRVINPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGAAKNSNFPDFPPVRMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDTV
>A0A375EZ44|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLDVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVKAVVGHAVTTLEGLGTAQHPDPVQQAFIEEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQAAQGAAS
>A0A375J910|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTRFQVNGQPKDVDVPDEMPLLWALRDELGMTGTKFGCGMALCGACTVHVDGTAIRACVT
PVSAVAGRSVATIEGMEGDRVGQAVQQAWIQHNVAQCGYCQAGQIMTAVSLLKTTPAPTE
RQIDEAMSGNICRCGTYPRIRAAIRQAASHLAQGAK
>A0A7Z7JCK0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNAKATTPSRGRRRFLLGALGLGGALVVGWGVMPPRSRLGGPAVFPEKSGQIALNGWIKI
TPEGNVILAMPRVEMGQGIHTALSMLAAEELDMPLTRVSIESSPIERIYGNVVTMGDSSL
PLHPDDADKTWARALHWIMAKSAREIGLIITGASSSVADGWQPVREAAATARASLVEAAA
REWGVRAAQVTVREGQLIGPGGKQMPFSAVARKARDIAPPSSVTLKPAAQYQLIGKPATR
NDIAAKTDGSARFAIDARPPGMLYAAVVMCPVIGGKLKTFQSKAALAMPGVRYVVPFDGS
TGGAPGVAVVADHYWQARQALEKLEPVWDNGPHASLDSAEIRQQLVGALDSDKGGFTYRS
MGDGLKAFDKTGGATIVEAEYSVPYLAHAAMEPINCTAQVTRDGVQLWAPTQVATLAQLV
AARAAGVSRDQVQIDIPLIGGGFGRRLESDFIGQAVSIATRTEGRPVQVIWAREDDIRHD
FYRPQAIARLKARVENGKVTAIASRSAGQSILAGELERLFGVPSLGIDRYAAEGLFDLPY
EIEHEHIAHLVVDLPVPIGFWRSVGHSYTAFFLEGFLNDVAAAARLDPLAMRRDLLKAHP
RELKVLDTAAQAAGWNRPLAPAADGAPRARGLALHNSFGSMVAQVAEVSLKDGKPRVHRV
ICAVDCGTVVNPDIVAQQMESGIIFGLTAALYSQIQIKDGRIVQTNFPDYPMMKMAQTPV
IETHLVPSTAEPSGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMV
>K9NNR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. UW4|TrEMBL
MSRLPNDFTLSNLSQLSRRGFLKGVGATSALVLAASWGWQDAFAEEKDKKFGADGMPHGW
VDDPKVYVSIAADGTVTVICNRSEMGQGVRTSLTMVVADELEADWARVKVQQAPGDEARF
GNQDTDGSRSMRHWYEPMRRCGAAARAMLEQAAADQWKVSVGECHAQLHKVIHKPSGREL
DYGALAAAASALAVPARDSLRLKQPSEFRYIGKEGSKAIDGEDIVNGRAVYGADVHFDGM
LYATIARPTVYGGKVKSFDGSAAMKVPGVVKVLQIESRPLPSEFQPLGGIAVVASNTWAA
IKGREALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNIDEAMSSADSTLEASY
YLPHLSQSPMEPMVAIARFKDGACEAWGPSQAPQVTRERIGERLGLPFEKVTFNVTLLGG
GFGRKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPS
GWLHRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNIRLENPEATVHTRVGWYRSV
SNIPHGFAIQSFIDELAHKAGEDPLKYQVRLLGPDRQIDPRTLSEEWNYGESPERYPIDT
ARLRTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLVVHKADIA
VDCGPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVA
VHLVTPPGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLSGWQQAGA
>A0A7W7B2F0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingosinicella soli|TrEMBL
MPQISRRKLLIGIGAGAGLAIGYAVWPRRVPLNLAVREDETLINAWLKIGADGRIVVAVP
QAEMGQGVYTSLPQLLAHELGADWKTVSVEPAPVHPAYANRAMAEGMAAEAPGFLQGIVR
WAATTVVERYSLQLTGGSTSVAAHWEPLRTAGAAARALLCAAGAKWLDVDVAACDTVNGF
VVAPGGKTIAFKDLLADIDPDDAPDEPQWRADGTGPFLGKSMPRLDTPGKVDGSAQFGAD
VRLPGMIYAAVRGAPHGAAGLTAQLPKTARKGGVIGLVIGPRWYAVTGDTWWAARQALDL
VNADFEPGESMADSLAIEEALDEALHGDDGTIFATSGDIDEGLETGKRIEADYSVPFLAH
ACMEPMTATARVENGKVEVWVPTQSATLVVWRVADALGVAEQDVTVFPTLLGGGFGRKAE
VDAAVQAALIARDAGRPVQLIWHREEDMARDMYRPPAKARMRGTVNADKKIGAFDIKIAA
PNLGESFMSRNIPALASGGDSAAMLEGALSIPYSVPVFRAAHVDVPTPVPLGYWRSVGHS
YTAFFCESFVDELAQAAGIDPFEFRLRMMEEGSREAEVLKTAASRGSFSAVSEDHIGRGI
AIHRSFGSIVAEVVEVEAPSIEQVTVKRVTCVVDCGRVVNPDIIRAQMESAIIFGLTAAM
HGQVRFAEGEAEQLNFDSYPLLRIDETPEIDVHIMTSDAPPGGVGEPGVPPLAPALVNAI
FAATGERLRDLPLYRY
>A0A375D0S8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLDVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVKAVVGHAVTTLEGLGTAQHPDPVQQAFIEEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQAAQRAAS
>A0A375DYW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAVTPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLEHVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAALQLGVDASALEAENGVFRVRGAQASIRYAALI
AGEHVELPLAEDVPTKPVEAYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLDIDRESVRDVPGLVEVVVQGDFVGVVAEREEYAVLAARRLRVRW
KPVPPLPALDDPEPVLRANPATRRELLSEGELPAGDAGTVLRRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGTLLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPSIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDQRAADLLRAVADAAGWQRGAAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIDVVLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMASGKG
>A0A840HS03|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizorhapis suberifaciens|TrEMBL
MTKFTVNDRPVQYRMDPDTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAIRSCQI
SIAAVEGRFVTTIEALSPDRSHPVQQAWAAENVPQCGFCQSGMIMAAAVLLKKNANPSDA
DIEAAITNLCRCGTYPRIREAVKRAGRIARGEERVAAAPPPGIAPEDAAKVVPALSGQER
E
>A4A7F2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Congregibacter litoralis KT71|TrEMBL
MISLRVNGEHRELDVDPAMPLLWALRENLAMTGTKFGCGIAQCGACTVHLNGRAIRSCVT
PVSAAEGGEVTTIEGLADRTPGEGLHPLQTAWIEKQVPQCGYCQSGQLMSAAALLDSNPN
PDDAAIDAAMAGNVCRCGMYSRIKSAIKHAASQNRAVVQSFDPGASVNAEDDVGEKAHG
>A0A7W5E965|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MITLEVNGRKMAVDTEGDTPLLWVLRDELGLTGTKYGCGLALCGACTVHLDGVATRCCVL
PVEAAVGKKITTIEGLAVQEKPHALQALWIKHQVPQCGYCQSGMLMAAASLLAGNPKPTG
QQIDAAMTNICRCGTYPRVKAALQEARTIDIRKVPT
>A0A840U523|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter oulmenensis|TrEMBL
MISLTVNGQEHELDVPDDMPLLWVIRDVLGLTGTKFGCGIAQCGTCTVHMNGVATRACVT
PVSAVTGEVTTIEAMADDAVGQKVQQAWLDLGVPQCGFCQCGQIMSATQLLKDNPQPNRQ
DIVNALTGNLCRCGTYNRIVAAVERASGQEVTS
>A0A7W5K6M2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK069|TrEMBL
MTRLTVNNEAIEYRLPAETPLLWALRDASNLTGTKYGCGTGSCGACTVDVDGRAVRSCQM
TLAAAEGTFVTTIEGLSRDRTHPIQLALLAENVSQCGFCIPGIVMAAAVLLRRDPMPSEE
AIAAAITNVCRCGIYPRLTAAIQRAGRAIRGEERLPTGARPGIEPAGAARQVPALDPRQR
>A0A841HFF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MGKWTRRAVITAGSLVGGGLALGVGGIAFAPNRIGILSKGDGKEAAQLTTWLKIAPDNMV
TAIVPHCEMGQGVHTALTMMLAEELDADWNLVRMEEAPAEEIYANGYIARAFVPGLSDVP
KFTERFVDWGTYRLTRLMDLQVTGGSSSVRGTGFLGMRVAGGAARTMLIEAAAKRWNVPV
GECETKLSSVIHPGSSRSATYGELAADAAKLDPPVHPQLKSADKYTIVGKPIPRIDIPSK
VDGSAKYGIDVAIPGMLYATVAAAPVFGAQLGSVDATPIANLPGVKKVVKLDNAVAVVAD
SYWRALKALRTLIPTFTETTQRKENSETLASTIGRALEGDESKKIFSSGDAAATIGGAAK
AIEAEYRVPFLAHATMEPMNATARIANDRCEVWTGVQDPLAARKVAADASGLDADQVTLY
NQQLGGGFGRRLPGAHDFVDQAVRIAKEMSPAPVKLIWSREEDIQHDYYRPAVIGRYKGA
VDSKAAPIVWISKFNGAGGEAAHVPYAIAHQDIRAVKFGSHVRQGSWRSVEHSQHGFFTE
SFIDELAHAAGKEPYEFRRGLLEHAPRHRAVLEKAAWISGWGAAPAAGRARGIALVESFG
SIVAEVAEVEIVDGRIKVHNVWAAVDCGYVVNPDTATAQIEGGIIFGLSAAVFNEITIQD
GRVAQSNFNDFPLPKIADAPRIKVEFIQSNAALGGLGEPGVPPIAPAVANAVFALTGKRV
RSLPLKV
>A0A841HIC1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MTQTTISRRAFIQTSVAAGGGLLLGFHVPGADAASVEAHPWKTPTDGVEINAWLTIDRNG
VVTVRVPHTEMGQGALTSVAMMIAEELNVDWSKIQAVFADPNRHLTRGREYKVMTTHGSQ
LVRLQHPHIMQAGASARERLKAAAAQAWRVDRSAVEAKLGVLKSGKRSGTYAEFATAAAA
IQLPTEPAIKTPDQWWLLGQSKQRLDIPRKVDGSAAFAIDTRLPGMVYAAVKCCPVPWGK
LKSFSFDAVKQRPGVIAAIELKAVPGKTAFSDMQNGVAIVADTWYRAKTALDLMPIEWDF
GPAAQSSTESQWAEARKLLEQPGEVSNATGANAIEMIGAGGKVIAAEYHRPWETHARMEP
INATVSVTDSRVDVWSPTQDQSLALTLAADQTGRDVKDVFVHTVFLGGGFGGGGGGNTAV
TRQAAELSRQLKRPVKVVWSREEDINHDKQRPPNMTAFKALLGDKGLPSAWFTRSVWFTQ
DGMPRIGAAHADYSIGNMPYKVPNRHHERHNGKTHIPTATHRAPGAGQHGFMTESFVDEV
AIAGGWNPLDWRIEMTKGMDDWQRVLLTLKEKSGFRTDLPRGEGMGIGIVESHGSIAAAC
ATVTVSRRGALHVEKLVIVVDSGHVINPLGGIEQCEGSAAWELSHAWVGGLDLKEGRFTN
TNFDTYNLLRIDQMPQVDVHFALSGGSKWGGLGEPAGPPVPPAVANAIFYATGKRIRSTP
FRSHDLSWS
>A0A841HI55|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MPQYVLKVNGDEHVIDAPNDMPLLYVLRDRLGITGPKYGCGVGICGACTSHVGNSVARPC
IVRIDSVGAQEVTTIEGLATGDVLHPVQQAWIDEDVAQCGFCQPGQIMTAVALLAQIANP
TDADIDAAMSENVCRCGTYVRIRAAIKRAAAALQQA
>A0A3G7JIS1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGSVVGQNVSTIDNLHSDPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKVNPNPSD
EQIEAAMVGNICRCGTYNRIKTAIRQASSHLKEVQA
>A0A1X7A3Z8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax jejudonensis|TrEMBL
MANFTVNGEDVALDVPDDTPLLWALRDDLRLTGTKFGCGIAQCGACTVMVDGMPRRSCVT
PVGTLEGASVETIEGLEGPEAEAVQSAWVQIDVPQCGWCQSGQVMSAVGLLRLNRAPSDD
DIDNAMAGNVCRCATYVRIRQAIHDAAATLEG
>A0A853D7G3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda sp. ARW1Y1|TrEMBL
MASFTLNINGKQQEVDVDPSTPMLWVLRDHLNLVGTKYGCGIAQCGACTIHLDETATRAC
MLTVSSVGNSEITTIEGLSEEGDHPVQKAWLEVDVPQCGYCQAGQIMTASALLEKNPNPT
DEEIEMAMNGNICRCGTYTRIKKAVKLAAKS
>A0A239STN2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea sputorum|TrEMBL
MEFQLNGRPFVFDGEDDTPLLWVIRDAAGLTGTKYGCGIGACGACTVHIEGVATRTCVLP
VSAVAGKRITTIEALSTARSHPIQQAWIANDVPQCGYCQSGMVMAAAALLDKHPHPTDAQ
IDEAMTNLCRCATYHRIREAIHDAAKR
>A0A388RS57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MWVIRDVLGMTGTKFGCGMALCGACTVHMEGAAIRSCVTPVEAAAGKSITTIEAVHTTAA
GRAVQEAWLDVDVVQCGYCQPGQIMSATALLMQTPSPTDDQIRDGMAGNICRCGTYERIH
AAVKQAARIVQQPSKGAR
>A0A239S9R8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea sputorum|TrEMBL
MASFQLNGKTVKVDVDPATPLLWTLRDALNMTGTKFGCGMALCGACTAHLDGQPIRSCVT
PVSAVEGKKITTIENVGADPVGAAVQAAWVKHDVPQCGYCQSGQIMSATALLRDNKTPND
EQIDTAMAGNICRCGTYARIRAAIKDAASSLA
>A0A0P0RD34|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caribensis MBA4|TrEMBL
MSQGLLDAQNGKPRDDDAARVTRRTFLKFSASVAAMAGGGLMLGFSMPAQSQGDVRKSVI
GGDGVETPQSGVLAPNAFVQIDTAGKVTLIIPKVEMGQGVYTSIPMLIAEELEVPLESVT
IDHAPPDESRFTDPLLGGQLTGGSTSIRYAWEPMRRAGATTRVLLINAAAQQWQVDPASC
HAANGQVIHADTKRSIAYGQLVDAAAKLPVPQNVPLKNPKDFKLIGTQAKRLDSPEKVDG
DAVFGLDVRLPDMVYAAIVNCPVFGGTLASVDDTAAKKIPGVRQIVKIDNGVAVIGDHTW
AAKRGASALKITWNEGAGAAVSMKTIVDDMEKASQNNGAVARKDGDVSNAFSQAKTRVDA
VYQQPFLAHATMEPVNCTVHVKPDSCEIWVGTQVPTRARDAGAKVTGLSPDKIVVHNFLL
GGGFGRRLEFDMVTQAVKVAKQLNVPVKVTWTREEDIQHDMYRPYYYDKISAGLDANGKP
IAWQHRIVGSSILSRFAPPAVKNGVDPDAVEVAADLPYDLPNQLIDYVRQEPHAIPTAFW
RGVGPTRGTFVVESFIDELAAQTKTDPVKYRRDLLGKSPRALNVLNVATQAAGWGSTVPK
GQGRGVSVMHAFGSFFSMVADVTVDQGEVRVNRVVCAVDCGIVVNPNTVEAQIQGGIIFA
ITAALYSEITIDRGRVQQSNFTDYRILRINETPTIDVHIVKSSEAPGGIGEPGTAAAQPA
IANAIFAATGKRLRQLPVGNQLINA
>A0A7W5EIH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteibacter sp. Sphag1AF|TrEMBL
MSGEIQLSRRRFLKFASCAAGGLIIGVSTASALERPAPVALLGDAWSQLGPYLRIAADGR
IFIGVRDPDNGEGTSTSLARLIADELDADWSRVIVEPLGLGVEAGNGEPRWTYGRQHSGD
ADSIPAAWADLRQAGALARWLIFQAAARRLGVPAEQIHGANGMAIAADGRRLAYGDLASA
AAALQAPTTAPPVKTADHYTLIGQGVGDVNARDIVTGQLKYAIDQTLGDTIVAVLARCPY
PGGTLDTADREAAKRVSGVYDVIDIGPETGQQPGYTPQAPGLAVLAKDTWSALQGRAALK
ATWKPGAFVETGTGALEQQALAMFDNETVVPSTARDDGDVAAARKKAARALEATYFQPWV
AHATAEPPNCLVRLDPDTSVTVIAATQAPRQAYAVVQRLTGFTPEQIDIRVPRGGGGFGR
RLHHDQVAEAMLIALAKKPDEIRNRTIRVMWTRDDDLTHDFYRPMAVHRINASIDAKKRV
VGWHQRMASPSIQKGRGVPDERLWQSEMMPDALPAGLVPNFRSDWYPLESQMLRGEWRGS
PHVTPTFATESFIDEIAHSLKANPLDYRLSLLGEGRQLPYNGRGGPIDTARLANVLRLAA
ERIDWSRWLRSENGLGIACAYVWGAYIAHAVEVIPTTDGVDVTRVVCAVDVGRPINPTGL
QGQIAGATMDALSTALNLAITVKDGQVQQRTLRDYPLANSAQMPNEVEVFIVPSTAEPTG
ASVMGVPSAAPALANAVFRATAVRVRRLPLLRELARLR
>A0A7X0GX72|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis sp. JAI128|TrEMBL
MTRFSVNDRPVEYRMEPDTPLLWALRDASNLTGTKYGCGTGECGACTVDIDGEAIRSCMV
TIAECEGRFVTTIEGLSRDRSHAVQQAWAAQQVPQCGFCQSGMIMAAAALLRANSNPSDA
EIDAAMTNICRCGTYPRIRTAIRLAGRVLRGEERIAAAPPPGIRPDDAARAVPALRLPPG
S
>A0A1V0RSQ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus|TrEMBL
MGRARTIARRSFLIGSAAILGGVAFGAYFVSRPIANPLLDGLAQGEAALTPFVKITPQGI
TLIVPRADVGQGIASTQAMLIAEELDIDPATATLDPGQPHQAYFNGVIVGESMPFPAWEH
GAVANTMRDVMRNVARLTGSQFTGGSSSVADLHETLRLAGATARETLKAAASARTGVQRA
DLRTKAGQVVLPDGTRIPYTELAGEAAAIAPVADVTLRPASDWTRLGKPYQRLDIVAKST
GTQDYGIDVVLPGMLHATVRANPGRGGAMAGYNADAALAMQGVRAVVAVNEGLAVIADNT
WFAFQAAQALEVDWLPPDHPASSAEMWQALSAARTDAFRNSRLRDDGDVEAALAGATVIE
AEYRTPFLAHAALEPLSATVLVEADSVQIWTATQIPAVVRDAAVALTGLDPSQVTLHALP
AGGSFGRRLDHDYVVQAIQIAATMPGTPIKTTWSREEDMTHDYPRPLHMAVGRGAVGNGR
VLAYDLDSVSPSLISSWFGRISSVPPGPDTMLVWGAFDQPYAIPNYRVTGYAAPQMIPVG
SWRSPGACSNTFFHESFLSELIHAAGADPLEERLRLIADPDSRRVLEAVGEMANWAGADI
GPGRGRGIAFAHTHGVPVAEVLDVTLTERGIRIDEVWIAADCGTVFDPANAEAQLTGAAI
FGLGHAMNCELTYENHAVLQTNFDAFEGMRLHQTPRFHTQLLGRAERVRGLGEPATAPAA
PALADAIFAATGRRLREMPFSKFISFA
>A0A6M4H6W3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter palustris|TrEMBL
MDTFVTRRDFLQAIAATGGFALAGGINEVFAADPPKYGADGMPNGWIDNPLVFVAIAPDG
IVSVTCHRAEMGQGVRTGVTMIIADELEADWSKIRVVQAPGDEKKYGNQDTDGSRTTRHF
FTPMRRCGAAARQMLEGAAAAKWGVPVSEVKAANHVVTHAKSGKTAGYGELAADAAKQPV
PTGAAIKLKDPKDFRYIGKGKTPIVDGFDMTTGKGMYAQDVVMPGMLFAVIARSPVYGGK
VKSFDATAARQVKGVVNVVEIKGTDIPAAFAPLAGVAVIAENTWAAIQGRKALKIEWDGG
ANASYDSDKYRAGMEAAAVKPGKVIRTHGDVDKAMAGAAKTLKADYYIPHLAQAPMEPPA
ATAVVKDGKCEVWTCAQSPQAARNDVAKRLGMKPEDVTINVTLLGGGFGRKSKADFAVEA
ALLANEMPGKPVKVVWTREDDLHHSFYHTVSVEHLEAGLDKSGKPVAWLHRSVGPTLMAL
FMPDPKVESAIEIGMGLANVPFEVPNVRIENPEAAAHTRVGWYRAVSNIPHAFAVQSMVC
EMANAAGRDPKDFLLELMGPARKIDPRTLNDTWNHGEDPSLYVYDVGRLRNVTEIAAKAS
GWGGKLPKGQGRGIAAHYSFTTYVASVIQVAVDAKGALTIPRVDIVIDCGAQVNPERIRS
QMEGAVIMGLSNAMLSEITYKNGAVVQDNFHQYEILRMNMAPRAIHVHLVPGDYSKHMGG
VGEPGVPPIAPALCNAIFAATGKRIRALPIKDQLKA
>A0A0N7M8Q8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria denitrificans|TrEMBL
MALTLKLNGETHTVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLNGEPVRSCQ
TYIEDVEDAEITTIEAVGADKIGSAVQQAWVELDVVQCGYCQSGQVMSAVGLLSENPKPS
TEEIDDYMHGNACRCATYQRIRAGIQRASEILEA
>B8IVX4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)|TrEMBL
MNAPVFSRRALLQGGALVVGFSLAGRSALAQTAASVATNGFSKAIAPDQVDSFLALGADG
RATIFSGKVDLGTGVETAMAQIAAEELDLPLDHVTVVQGDTALTPDQGPTYGSLSIQKGG
VEIRQAAATARARLVQLASERLGAPIDALVTENGSVRPKAGGTGVSYADLLKDGRFETKV
DSAVTTKDPAQFALVGKSVPRLDIPEKMTGHFTYMQDFRVPGMVHARVVRPPAISATLKS
VDEGSVASIPGLIKVVRQGNFLAVVTEREWAAIKAASQLKATWSAWAGLPAQDQLWEHVR
ATKVTKDDVTSSTGDAEGALAQASKVLQATYDFAIHTHGSIGPSCAVAEFKDGLLTCWTA
SQMTHALRMQLAAMTGLAPEAVRCIYIEGSGCYGRNGHEDAAGDAALLARAVGRPVRVQW
SRADEHGWDPKGPPTLIDLKAGLDAAGNVAAWSSQFHVPEGAAGNVPLVAATLAGLPHET
TMAPGNVIQNSALPYGFPNVRTVCHRLADTPFRPSWIRTPGRMQNTFANEAFLDECAATA
GADPLEYRLRVLKDPRGITVLKRVAEIAGWQARPSPLKEDARADVLRGRGLSYVRYELNR
TYVAGVAEVEVDRKTGQVRVPRFFVAQDCGQIINPDGVRNQLDGNVIQTVSRVLMEEVTF
DRSAVTSLDWASYPIITFPDVPQVVTDLIDRPTEKPWGAGEPSAAIVPAAISNAIFDATG
ARLRSVPFSPAKVKAALQGT
>C4B2G0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia mallei GB8 horse 4|TrEMBL
MSMSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRS
CVLPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAP
TDADIDAAMNDNICRCATYTRIRAAIHEAAATLKA
>A0A1Y0UVK9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ascendens|TrEMBL
MSTHSPSSAARLKTGRRRVLQAGGALLLATLWPTPRGRAAQATQAGTGVLVEDVAAPFAP
NAFIRIAADNTITLILPNIEMGQGIYTSSVMLIAEELGVDPFAVQIEAAPPGGGAEITGG
STSIMTEWLPLRQAGAAARTMLVQAAATHWGVAPKSCTTATGAVIHRPSNRTLPFGDVAA
DAAKLPVPKNPKLKDAASYKLIGYKHHRLDSQIKVDGTARFGMDVQVPGMKIGTVAACPV
QGGTLHGMNRNAALAVNGVHAVLVTDNKDTVCVVADHYWAARKGLKALHIQWDFGKNAAI
TTQTIYDDLHAGLNGPAIVANAKADAPEVIGKSGTTYTATYQQPLLAHSPMEPINCTAHV
RPDGCDIWAGTQVAERARDTAAEITGLPASKITVHSQYIGGGFGRRLEHEYVTQCVQFAK
QVPYPLKIIWSREEDITKDRYRPAYVDQLTAALDDKGYITALQHRIVGPAVVARWDPPEL
TKDGYDDDLSLATVVTPYTYPAYRLEFARREAPGITTAWWRGVGGTRGLFVVEGFIDELA
ARAGADPVAYRCAMVQHNPRALAVLERVAEYAGWGTPMPKGRARGVALQFAFGSYMASIA
EIEMPSPDEVIIHCVTAAVDCGQVINPDQVIAQIEGGLIFGFSAALYNEITLENGRVQQQ
NFNTWRVMRINEAPRRIDVVVMPSNEDPGGIGEVGTAAAAPLLANAMAAAQKRRYRSLPL
LSARNTEGKE
>A0A3G6ZXM6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. CMR5c|TrEMBL
MSPLPTDFTLANLSRRGFLKGVGATGALVLAASWGWQDAFAEDKKFGADGMPHGWVDDPK
VYVSIDADGSVTVTCNRSEMGQGVRTSLSMVVADELEADWALVKVRQAPGDEARYGNQDT
DGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWQVPLAECRAQLHKVVHQPSGRELGYGDL
AVAAGALAVPARDSLRLKPASQFRYIGKEATRAIDGQDIVNGRAVYGADVHFEGMLFAVV
ARPRVYGGKLKSVDDSAALKVPGVIKVIPIESRPLPSEFQPLGGVAVVASNTWAAIKGRE
ALRLDWEDGVNAGYNSIDYRKELEAAAHQPGKVVRSTGNLEQALGSADGSLEATYYLPHL
AQAPMEPMVAVARFQDGRCEAWAPSQAPQVTRERIAERLGIGFDQVTVNVTLLGGGFGRK
SKPDFIIEAAILAKAFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGLNKDGMPAAWLHR
TVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAAHTRVGWYRSVSNIPH
GFAIQSFVDELAHKAGEDPLRYQLRLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRLRT
VLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKGDGTLIVHKADIAVDCGP
QINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVQVHLVT
PPGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQQASA
>A0A7W6DLJ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sagittula marina|TrEMBL
MATFDLNGKEVTVDVPDDTPLLWVLRDEMQMTGTKFGCGVAQCGACTVMLNGMTRRSCVT
PISMVDGSSVTTIEGMDGPETKAVQAAWESLDVPQCGWCQSGQVMSASALLREIPKPTDE
DIDNAMAGNICRCATYVRIRKAIHDAADSLEG
>A0A0J9EBR4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Rhodobacter lobularis|TrEMBL
MATTITVNQTERSLISSEETPLLWVLRDELKLTGTKYGCGVAQCGACTVMLDGQPVRSCQ
VAIGDIAGSDVTTIEAVSGVEADAVRQAWVEMDVVQCGFCQSGQVVQAIGLLELNPEPTD
GDIDTYMGGNVCRCATYVRVRKAIHRAAEILAA
>A0A1Y0UZ05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ascendens|TrEMBL
MGKLERIAARQDRAAGRGPTRRGFLLTAMGSAFMFGFARQGNAAQVYPQAAGNLPAGGAF
EPTIWCSIAPDGWVNVNVIRAEMGQHVGTALARIIADEMEADWNKVRITYVDTDPKWGLM
ITGGSWSVWLTWDQFRQAGAAARTVMVEEGARLLGVAPSACIARNGQVIAGKRSISYGDI
VSRAHPTRTFTPDEMAKLPLKPSSEHRLIGREVKALDIPSKTDGSAIYGIDAKLEGMVYA
RPKMPPTRYGSKVVSVDDTEAKKVKGYIRYIVLEDPSNTVPGWVAVLASSYPAAIRATDA
LKVTWTPGKTANVTEQDIIEHGRKQIAEKTGGSRIFNDAGVDEALAKADKVVERTYTCSS
VLHYQLEPMNALARLHEGKWEVHCGNQWQTLFLPVIAKALQVPESDVVMRSYLLGGGFGR
RLNGDYAVPAALISKALGGKPVKLVFTRSDDVLFDSIRSPSIQTVRAGVNKDGSINGWEH
HASAGWPTGVMAAAFMEKGEDGKPYDQFAIAGADHWYDVGPILVRALDNDLADATIRPGW
LRSVSSGWTPWAHECFLDELAHDYGKDPIDFRLGLLTCKGRNAGSAPNSVGGASRQANVL
KKLVEKCGYGKVSLPKDTAIGIATTFGQERNMPTWTAGAAQVHVDRETGVVTCQKIWLVL
DAGTIIDPDGALAQTEGGALWGLSMALFEGTEIENGNVRDRNLNTYTPLRITDVPDMDIE
FLPSTEKPMGLGEPGVTTIAPAIGNAIFNAVGVRMRHLPVRPADILKALKEKGNA
>A0A840TG47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhabdobacter roseus|TrEMBL
MALFKLQINGRSYQADVEPDTPLLWVLRDHLGLVGAKYGCGIAQCGACMVHLNDEATPSC
VLPVSAIGASKVTTIEGLSEKGDHPVQQAWDEVDVAQCGYCQAGQIMAAAALLKRKPKPT
NEDIDATMSRNLCRCGTYHRIREAVKVASTKLN
>A0A158S2C5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. KN65.2|TrEMBL
MDMIVDAPRGGNDGLQQFFVGEPSNISRRRFLLTSAGVSAGALVLGFGIPMGKARAQEGK
SGIPDAAAHPKVPAFLEIRPDNTVRLQSPFIEGGQGVFTAMAQIVAEELDLDPSAFTVES
APAGSEYLIVPGAGRLTGGSMSVRTSYMTMRKIGASARLMLMQAASGKLGVPFSSLTTQP
GRVLHEASGRSLTYGEVASGALDMPVPPQDGLKLRDPKTFRWIGKPVARIDMHEKATGKA
QFTIDVVVEDMVHAAIQHAPRLGLEVGSIRNEGQVKAMRGVESIHRLDGAVAVVAKRWWH
ARQAVEALQVDWAEPGDKSGIRYMPDDFDSEAFSQQLGANADAGNEAESRGDFAKGFSDA
ATKVEATYYSQYLHHAQLEPPSSLARFNADGTLDLWVPNQAPEMFQADAAKIAGMAPAKV
KIHSQMLGGFFGRHFLYGPGCCYPQAIKLAKAVGKPVKVIWSREEEFLRDPLRPMAAVRF
RGGLDSNGMPIAIEAISACEGPGEGIANKRAEGVDGMAVEGLTGKSYAIPNSRIAQAYVK
NPVTLAYWRSVGNSMNDFFYETFLDELADKGGIDPFEMRLRLLRDNKRLTTLLKAVGDLA
GGWKRGPFSAADGTRRARGVAMASPFGSHTAAIAEVSIKDGQVVVHELWEAIDPGSIVNP
AIVEAQVNSAIALGLSQVLLEEAVYKDGQPVARNYDLYPILPPDRMPRVHVKIVESGAEM
GGIGEPPLPAVPPAVANAVSALTGKRVRSMPLSRIKFDT
>A2SLZ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)|TrEMBL
MKRRTLLLGAAAAGGGLLLGWAALPPRSRLGDRALLALQAGEVAFNGWIKVAADGGVALA
MNRSEMGQGVHTTLPMLVAEELDIGLDRVRLVQAGADAVYGNVATFVASLPFHPRDSEPG
RRTAAVKGGEWVVAKLARELGINMTGASTSIVDAWEPLRLAAATVRAQLVGAASLRWRLP
KEEIAVRDGVVSHASGVHAHFGELAGAAAGTPAGDVALKPRAAWTLIGRDTPRTDVVAKS
DGSAVYGLDVRPEGLLYAAVRMCPVLGGAPQRIGNEDEVLRRPGVQRLVRLPARAGATAG
VAVVARSSWHARQAVEALAIDWASPPAGTVDSQAIAASLEAAARDALAQDGGLAYHRRGD
VAAAERGAGPGARTVEALYRAPYLAHFALEPINCTAQVRDGHVTVWAPTQVPGIARAHAA
RAAGVDERAVTLHVTLLGGGFGRRLDADFVAQAVAVAQETGGRPVQLLWSREEDTTHDYY
RPAAAAALKAVLGADGRPLSLRIASAGDAITPRWMERGLPWLAGPVDLPDKTTAEGLFDQ
PYDIAHQRIAHVATRSGVPVGYWRSVGHSHNAFFLESFIDELAHAAQQDPVAYRLALLAG
SPRHAAVLQLAAQQSGWGRPSPAGRARGVALHESFGSIVAQVAEVSLAAGGVPRVHRVVC
AIDCGTVVNPGIVRQQMEGGIVFGLSAALHGGIDIVAGVVQQKNFPEQPLLTLAESPRIE
THLVASEHPPGGVGEPGTPPIAPAVANALFALTGVRRRGLQLRG
>A0A653UBY3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. 9I|TrEMBL
MSKYTLNINGKAQAVDVEPDTPLLWALRDSLGLVGTKYGCGLGQCGACTVHIDGVPARAC
LTPVSSLGKQKITTIEGLDAKAQHPLQEAWQELDVPQCGYCQAGQIMTACHLLKQHPKPT
DAQIDEAMAGNLCRCATYTRIRAGIHRAADIAANGKGKK
>A0A6J5GNR2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MSNMSPARAPLSRRQFLKMFSAAGGGLMLGIAFPTAVDAAPIVPDSSEANVFAPDAFIRI
APSGQVTLIMPRVEMGQGSYTSIPMLIAEELEIALDNIALEHAPANDVLYRDPVIGSQIT
GASASTRSEWLPMRQAGAACRVLLVNAAAMNWKADPASCRAENGTVRHVPTGRTLSYGPL
SVLAAKLPLPHNVALKDPRTFKLVGTPVKRLDARAKVDGSAGFGIDVRVPGMRIATVAAS
PVVGGRLKSVDARRALQIAGVKQVVQIDDAVAVVADHMWAAKQGLAALVIEWDDGVNARF
SNASLIAKMEQASANDGVVAQHIGDVANALNGKGNRIEARYELPFLAHATMEPMNCTVHV
TLDGCDVWCGTQVPARAQATAAEVTGLSLEKVRVHNQYLGGGFGRRLEVDYVTQSVRFAK
QVQGPVKFVWSREEDIQQGLPRTYYLNRFEALLDSSGQPQAWAHKVTGAAVMARYLPSTF
KNGVDPDAVNGAINLLYDIPNVKVNYVRYETPMPIGKWRGVGPTHNVFVVESFMDELAHA
AGKDPFEYRRALLAHQPRAKRVLETAASEAGWTTPLPAAKRGVRIGRGISVQFAFASYLA
EVAEVEVNEQGQVRIRRIVCAVDCGHTVNPDTIRAQIEGGIVFASSAVLWGEITFRNGRI
EQGNFNDYRVMRINEAPAIETHIIDSAEAPGGIGEAGTSALFPAVANAVAAATGTRIRKL
PINPAMLKV
>A0A840ZZI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodesianum|TrEMBL
MIHEAKLMAELAAAKDSAGPVRLDNFSRRGVLGGMGALVLALSLSDRARADEGASKEKEK
KFGADGMPNGWRDDPKIFVAIAKDGTVTVTNHRSEMGQGVRTSIAFTVADELEADWSKVK
VVQAWGEETHFGNQDTDGSRSLRHFFQHFRHAGAAARLMLIQAAAKQWGVPASEVKAENH
VLTHAKSGRTLGYGDVAEAAASLPVPARESVQLKKPEAFRYIGKGKIGLIDNHDITTGKA
IYALDVKLDGMLYAVVARPAVYGGKVVSFDDTEAKKVPGVVKIVKIEGGEIPSEFMPLGG
IAVIAKNTWAAMKGREALKVTWDDGPNASYDTDAFRKELEAAARKPGKVVRVAGDVDAAM
KTAKSKFEAEYFVPHLAQAPMEPPAAVARIKDGACEVWACTQGPQAAHDRVVKRLNLPAD
KVRVNVTLLGGGFGRKSKPDYVVEAALCSQAVDGQPVKLVWTREDDIQHSYYHTISVERI
EAGVDDKGMPVAWLHRSVAPTIGSIFAPDPKHELPFELGMGLVNNPLALKNLRFENPEAS
AHTRIGWFRSVSNIPHAFAIQSFVAELAHAAGRDPKDYLLELIGPARKIDPTEIGDVWNY
GEDPKRYPVDTGRLRRVIETVADGAKWGRKLEKGRGLGIAGHYSFVTYTAVAAEVEVDDK
GQVKVHAIDIAVDCGPQVNPERVRSQMEGAVVMGMGLALTSKITFKNGRAEQANYDGYEV
IRIDAAPKVVRVHLVPSNDYNAPLGGVGEPGVPPVAPAIANAVFAATGRRVRELPLRDQL
ST
>A0A1Y0XW47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus subsp. pasteurianus|TrEMBL
MPTLVINGQPHSVDVDADTPLLWVLRDILGLNAAKFGCGIAQCGACTVYVDGKAVRACNL
PVGLVGERAITTPEGLDMADPVVRAIKSAWVALDVVQCGYCQPGQIMAAVALLRTTPNPT
DEQIDSAMSGNMCRCGTYMRIRAAIHHAAGELA
>A0A7W6DL14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium fontiphilum|TrEMBL
MTRFTVNDRPVHYRMDPDTPLLWALRDASNLTGAKYGCGTGDCGACTVDIDGEATRSCQI
SIAQAEGRFVTTIEALSPDRGHPVQQAFAADNVSQCGYCIPGVIMAAQALLRRTNDPSDE
QIDAAITNICRCGVYPRLRGAIKRAGRIMRGEEQVAAAPPPGIAPEDAARAVPALGKR
>A0A7W7YGG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prosthecobacter vanneervenii|TrEMBL
MSARNVISGQVSNELPPLPEPVIAHAGELQRREFLKGVGGLLLAFTFEMGARGKAAAAAA
GSTNTSITSYLAVGSDEAITVYVGGGEMGQGIYSGLAQGVAEDLFVDWAKVKVQPLPAAL
SWVTGGSSGIMRRLQTMRAAGATARQMLVNAAAQTWGVPATGLVTAKGTVTNPATKAVLT
YAQLAPLAATLPVPASVTLVPNNAFQVIGKNVPRQDIPAKTNGSAVYGIDVQVPGMVFAV
VKHCPTLGGTLASVPTTPVGALGVIPLYDLSGKNINAVAVVASNTWAAKSAAENLQVRWT
LPATASTLSSTNFATQAQSLLSGAAPYTVEQSGNAAAMYASAPVKLDLQYNLPYLAHACM
EVLNCTVRITASTCEIWAPTQAPALVQQTGATMSGLPAAAVTVYPTLMGGGLGRKIEQDY
VSQAVQTAKAIGKPVKLTWPREEDMAHDFYRPMALSRIQIGLDDKTGKVLSWSNRVVAPS
LSIQRGRTLGATGDGIAVEGAASRPYNFLSRLVEYVPHPSPVPVGYWRSVGNSINIFAVE
SAIDEAALAAKMDPLQFRRNLLVNDARTLAVLNAAASAAGWGSALPAGHARGIAVSNAFG
SIVAQVAEISAPTAGSITVHKVACAIDCGYAINPGSVEAQMQGGIFHGLSAAMWGQVTFK
SGVASARNFSNYRMLRMKEAPQITVQIVNTNSPLGGIGEPGVPPIAPAVANAYAALTGVR
LRNLPFFPGATMSEG
>A0A509E855|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MITLTINAQPFTVEAEPDTPLLFVLRDSLGMTGTKYGCGIGQCGACTILLDGQAARSCQV
PVESVGDQTITTIEAIEQDPVGARVVAAWVGIEVPQCGYCQSGQVMAATGLLKQTPKPTE
DDIAGAMTNLCRCGTYNAIAAAVRQAAA
>A0A2N7QQ34|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. AD56|TrEMBL
MMLRVDPAQEEIELQNPARRELLKRGGLVVAFIWLGGASRVWGFAEGTRLNADDPRFAPN
AFVRVGSDGSIQLVMPCIEMGQGAYTGQATLLAEELDVGLDQITVEHAPANRKLYANPLL
GDQATGGSTTIRFCWTSLRDAGAAARTMLVAAAAQRWKVDASQCTVARGVVTHSASGRTL
RYGELADAAASIAPPTKPVLKDPKDFQLIGKPMRRVDTPGKVDGTLPFGIDIRVPGMKVA
TVQACPTFGGTLASVDDTRARAIPGVLKVVKLDNAVAVIGEHFWAAKKGLDALTIQWNAG
ANHQFTTEQLFKDLADTSEHGTPILGREVGNVDKVTGKVVSATYQMPLLAHATMEPINAT
VHVRPDGCDIWVGTQVPARCVDVAMRVTGLPAERIQVHNQYMGGGFGRRLFEDSVGQAVG
IARQVDYPVKVIWTREEDIAQDRYRPAYYDRISATLDDQGRPLAWKDRTTGASVLATFAP
PAMGKNGLDSDLVECAAELPYEVPNLRVDWVRHDMPNGVPIGWWRGVGPTHNVFVVESFV
DELAHTVGKDPVDYRRAILGDNPRAKAVLELAVEKSGWGKGDVPARHGRGIALAAPFGSY
LCVVTDVEVSPQGEVMLRRAVAVVDCGTVVNPNTVEAQIQGGLVFGWSAAMYSGITLKNG
AVEQRNFNDYRVLRLNQTPPIEVHLVPSKESPGGIGETGTVMAMPSLTNAIFAATGVRLR
TLPIDRSALVQDKDALKSVLSETSSASPTGRLA
>G0AHI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas fungivorans (strain Ter331)|TrEMBL
MSLESLVANSRPLKQSRRKFLKTSAVGGAGLVLGFFIPGLGRIAEAQAVALKISQPNAFL
RVGADNSVVVQVSKADIGQGTLTALPMLLAEELDCDWSNVRAELAKGEDVFRDPVFGMQM
VGGSTSVAHSFQQYREVGARARSMLVAAAASEWKVDPASCKTAKGVITGPRGQRLSYGSV
ANAAMLLPVPDKVQLKDPKQFTIIGKATPRLDTAAKSSGQQKFGIDLDLPGMKVAMLARA
VPWGAKIGKLDDSAAKAIPGVRKIFTIPGIRGGQSVVVVADGYWIAKKARDALNIEWDVS
GVEQPSSEQLFASYREAVMKPGTPATKADVSALAASPKIIDAIFEFPYLAHAPMEPLNMT
LHFSGDACTVWAGSQFQSNDREAIAKVLGLAPAKVEFNTMMSGGAFGRRALPESENAVEA
AYVAKAMRGTPVKIMYAREDDIKGGYYRPMHVHRVRIGYDAHGKIAAWEHVIAGQSILGG
SPFESSMVKDGVDSTMTEGVLESHYAIPNLALSVHNMKANVPVLWYRSVGHSHNAFVMET
LVDEIARSVGRDPVEYRASLFDKSAKRSKQALELAVARSGYGKRKLPAGQAWGVAVHHGF
NTSIAYVVEVSLKDGKPQVHRVTAGVHCNMAINPRTIEAQIQGGVVFGISTTLPGNEITL
KNGVVQQSNFSDYTPAYMASCPQVDIHVVPSADAPTGVGEPPVPPIAPAIANAVAALTGK
RLRKLPFDAVKA
>G0A912|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas fungivorans (strain Ter331)|TrEMBL
MSAAFDFAKDNANTEVASMSRRTWLKGVGAFTGLALTVGVNGLVMAANAAAPAKKYGGAS
MPGGTVNDPLIFVSIGADGIVTIIAHRSEMGQGIRTSLPLVVADELDADWGRVRVVQANA
DESRYGNQNTDGSRSMRHFFTPMRQVGATARLMLISAAAARWNVPAAEITTKNHEVLHAK
SNRKLGYGELAVDAAKLQVPAQVQLKDPSQFRYIGKDAFGSVDFRNIVTGNTQYGIDTRL
EGMLYAVVARPPVYGGKVASFDPAEALKIPGVVKVIELKGSPPPAKFNPLGGIAVIARNT
WAAIKGREALKITWDNGPHGGYDSTAFKVTLQEAARKPAKVVRNSGDTMAVLGQAGKRIE
AEYYIPHLAHATMEPPAATARTANGKCEVWACVQDPQATRDTVADRLGWKTADVKVNVTL
LGGGFGRKSKPDFVAEAALLSQAMDGVPVKVTWTREDDLRHDYFHTVSLEHLESTLDAKG
KPQAWLHRTAAPTIASTFVAGAKGEQPGELGMGAINIPFVIPNIRIEAPEVEAHTRIGWF
RSVYNIPHAFAVQSFVAELAAAAKRDHREFLLELIGPARQINPQEMSDTTNYGESPVLYP
LDTGRMRAVVELATKEAGWGRKLLKGHGLGLAVAYSFMSYVAAVIEVVVADDGTISIPRV
DMAIDCGPQITPDRIRSQVEGACIMGLSLALTGEITFKNGSAEQGNFHEYEVLRAFSAPR
DLRVHMVPHKSSMYDTMPLGGVGEPGTPPIAPALCNAIFAATGKRIRNLPIRDQAKKS
>A0A840GH46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR18|TrEMBL
MNFIDNPGKLHSFEKRGFEKNIKVEKVSRRSILKGLGITGGFVLAAPVMSRQALAYETGA
GKMPHGVVVDPRVFVSVGPDGIVTIVGHRSEMGTGVRTSLPLIVAEEMEADWSRVKVQQA
HGDEVKFGNQDTDGSRSTRHYLIPMRQIGASARTMLEQAAAKRWGVPATEVKAVNHEVVH
SASGRKLGFGELAADAAKESVPSIEGLKLKDPKNFRYLGKGQVGIVDLHDITTGKAHYGA
DVRLPGMKYAVIARPPVTGGKLVSFDPDAALKIPGVEKVLKVQGWPWPSKFQPLGGVAVI
ARNTGAAIKGRDALKLVWDDGPNGKYDSVAYRKELEEASRKPGLVLRKEGDADAALKGAD
KVIVGEYYVPHLAHVSMETPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLGIPEGNVTV
NVTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDIHNGFLHTVSVERIEAGLD
KSGKVVAWRHRSVAPSIASTFAAGTVHQAPFEIGMGLVDMPFEIANISCENPEAAAFTRI
GWFRSVSNIPRAFAVQSMVGEIAQATGRDQKETLLALIGSPRIVKPEVKDLWNYGEPQES
YPIDTARLRKVVELVAEKGEWGRKVPKGHGLGIAVHRSFVSYIATIVEVAVDDKGKLTVP
RVDTAIDCGTYVNPERIASQIEGAAIMGLSLAKYGEITFKDGKVQQKNFDDFQVVRMDES
PVVTNVYIVPPGPDTPPSGVGEPGVPPFAPALINAIFAATGKRIRSLPIGKQLEA
>A5EE69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MEVTINGKRHQVTMADDTPLLWVIRDELGMTGTKYGCGIAQCGACTVLIDGQVTRSCVTP
VGSVAGQQVTTIEAISDDAVGRRVVEAWVANQVPQCGYCQSGQVMAATALIKQTPKPSEQ
DIAAAMVNLCRCGTYNAIAAAVRQVAQG
>A5EFF8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MPPRTPEEVGMNKHVSPRLNRRSFIIGTAALGGGLALGLDLPFGGPQVVRAADGSPEVNA
WVVIRPDDTVVIRIARSEMGQGSLTGLAQLVAEELACDWSKVTTEYPTPGQNVARKRVWG
DFSTGGSRGIRSSQDYVRKGGAAARMMLIQAAADQWKVPVAECTAANSVITHKASGRTTT
YGKVAEAAAKLTPPADVKLKDPKDWTLIGKGVKRLDTADKVTGAMIYGADIKLPGMLNAA
IKDCPVTGGKLKSYDEAKIAGMKGVKKVVAVDGTAVAVVADTWWHAKTALDALPIVWDEG
ENAKVSSASIAKWLAEGLESGPAFVGNENGDAKAALASAAKKVEATYNYPYQNHATMEPM
NATALYTPERCEVWCGTQNGEAAFAAVLEASGLPADKCEVHKLILGGGFGRRGQTDYVRQ
AVQIAKAMPGTPVKLLWSREEDMTHGRYHPITQCKLTGGFDADNNLTALHMRISGQSILF
SLRPDALVNGKDPATFQGLAPSGEATIGYSVPNLLIEHSMRNPHINPGFWRGVNVNQNAI
YLECFMDELANAVGQDPLEFRRRLMSKNPKHLAVLDAVAEKIGWGSPAPEGVYRGLAQLH
GYGSYVAGAAEISVIDGTKIKIHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGC
TVKDGRIEQTNFDTYNSMRIAEMPKVEAIMIPSGGFWGGVGEPTIGVAAPAVLNAYFAAT
GKRIRSVPLRDQNITFA
>G2E5E7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thiorhodococcus drewsii AZ1|TrEMBL
MADSDAQLRLSRRALLRVAAASGGGLALGILFPAQAETSAPDQPQQDDGPETLAPNAWIR
IHRDGGIQLVVARSEMGQGVTTSLAMLLAEELEVGLDQIRVEQAPVDAAYINHLLGEQAT
GESTSIRDAWLVLREAGAVARQLLITAAAAIWSVPESRCEARRGVIHLLDDQRSLSYAEL
AATAAKLPLPALPALKPSGTWSLIGTTQRRIDAPDKVLGAARFGLDVRLPEMLYASIARC
DLIGGHITNWRENATRAIPGVLNVFAVRYGIAVIAESSWAALRGRETLEITTRPSTNLAA
DTQRIRNRLRIALKGRAAVAYKKGDVSAALNASPHQIESIYEVPFQAHACMEPMNCTADV
RRDHCDLYVPTQSQARARATAQRITGLPADRIAVHTTFLGNGFERRREQDFIVDAVELSK
ELKRPVQVIWTREDDLRHDFFRPMSLHRLRGGIDAEGRLTAWFHRVAGPSVLARIAPDQI
TNGVDPFMMAGATDLPYSVAHRRVEYRRADTPVPIGLWPGGGQGHNIFATECFLDELAHI
AGKDPLQLRRDHLTDRPRLLNLLNRAAEEADWDNPPAPGRGRGIALMEAFGSLIAAIAEV
SIEETKVRVRRVICAVDCGQAVNPEIVRAQIESGIAFGLTSALKGEITLTKGRVDQSTLR
DYPLLKANEMPDVTIHLVKSDAEPGGVSGLASPLMAPAVANALFSLTGEPVRSLPIRLG
>A0A0J6C102|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella pseudohinzii|TrEMBL
MTQLHINGQAKDVDVPGETPLLWTLRDELGMTGTKFGCGMALCGACTVHMDGTPIRACVT
PISAVAGRAVTTIEGIAADPVGQAVQQAWIDQNVAQCGYCQAGQIMTAVGLLKTTAQPTD
QDIEDAMSGNLCRCGTYPRIRAAIHQAAKRLAQGGKQ
>A0A6J5FUE6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinitolerans|TrEMBL
MRDPILRDEAAQGGAEPRATLTRRQFLAGMSALTLAVGFRGGLAVAASLDPAKLPFEPNA
FVRVNADGTVTVISEYLEMGQGTFTGLATMAADELDVSLDKVKVVPAQADVKKYANPIFA
TFGWTVQGTGGSTAMAGAWKQMREAAAAARMMLVSAAAKTWKVDANTLHVEDGVIVHAPS
GRRAGYGQFVAAAARESVPTHVVLKHPDDFKLIGSDKTRRVDVPAKVDGSAIYTQDIKVP
GMLVAVIAHPPRLGGKVQHVDASKAKAIKGVVAVVEVPGDGEVQGGVAVLAHNTWIARQG
RDALAITWDDSHAFALSSDDIYKQFRALADQPGVVAEKRGTVLNAAPEGGKYLEAVYEQP
YLSHAPMEPLNCLVHLQGSRCEIWNGEQWATGDQAMAAKELGLKPEHVTIHQLYAGGSFG
RRANPQSDYVREACRIVRAAHAQDINAPVKLVWMREDDMRAGYYRPLTVHKVRVALDKAG
NLVSWNHDVVGQSFMQLPKPDSVDPVLVEGTADIPYDIPNFKATQHAPKLPVQTQWLRSV
GHTHAAFVGETMMDEAARAAGKDPYAFRHALLASKPRHRGVLDLAAQKAGWSTPLAAGAQ
GTKRGRGIALQFAFGTYVAQVAEVTVQQDGSFTVDRMVCAVDCGTVINPDIVAAQVEGGI
GFGLAFLHTAITFDKGHVKEGNFNDYPVLRMSGMPVVEVHIVPSKEAPTGIGEPGVPPAA
PAVANALAAATGATIRTLPLGDTLRPA
>A0A7W6ES49|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella defluvii|TrEMBL
MSNRRTFLKTLGLSSASFVLGVSSFAKGNAVVNMTTDPLSLALEINPFIVIQPSGQITLI
NPRPDMGQGSTQAVPSLLAEELEVSLDQVTIAQSDGKGKYGNQTSGGSSSVRALWTPIRQ
AGAAAKEMLIKAAAQRWSVPESECYVEKAKVIHRPSGKSLTYGEVADDASKLEIPKNPKL
KDAKDFKIIGKYAPRLDVPARVTGKAVYGIDVEVPGMVYAVMLHSPMIHGKVVSIDDSEA
LKIKGVQKVLKCERPMPHRTSEAVAIIADNYWAALSAKKAVKVQWDNGTLGQTLTTAAYF
KKCAEAATKEGLKAEEEGDFAATFGAAAKKLEAVYETPFLAHAPMEPENAIAHIKDDGTA
EVWAPIQGPDWALRDLAGYLKIKPEQIKINVALLGGAFGRKAYHDFLLEACFLSKDVKKP
VKLVWTREDDITQGPYRPGMMARMQGGVDAKGNIVAYHHHPIGESIQFQVFKAPSNKPDD
WVCGELSQKEQKYNIPAFKISYTHVPTEIPIVWWRSVYASNFGFSQEGFFDELAHAANKD
PLKARLELMSDARFKKVLETLAEKANWGEKLPAGQGKGIAIFKSFGSISACCVTVAKQGT
GVKIEKVVSVIDCGHYVNPDNVKAQTEGNIVMGITAAVKKGITFTNGQSDHTNFHQYQVM
RMNEMPKVEIHIVESGAEPGGVGEPGLPPIAPALANAVFAATGKRIRRLPFDLNTLA
>A0A3B1DE29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MIDSKKTKNSPSRFLSLFDLFSYTQLKWLTKQRRDFCTGKKMGGTMQSDMEKSQSTSGLS
RRNFLKGTAVAATAVVATTGNSLAADPAKKKHVITGATDVVLNVNGKDYTIHIEPRVTLL
DALRNDLNLTGAKEVDNVTASGADTILIDGKPVLASSRLAVECRGKKIETIESLKKGDDL
DKVVNAFVTHDAQQCGFCTPGFVMATRAFIKKNPHATEEEIKKGLGGNICRCGTYHAVMQ
CALALTKK
>A0A840ZFJ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodinum|TrEMBL
MLTIHLNGAAREVDADPDMPLLWAIRDRLDLTGTKYGCGIAQCGACTVHMDGQPVRACQT
RIGDVGEAKITTIEGINGKVAEAVQGAWRKLDVVQCGYCQSGQIMSAIGLLTENPKPTDA
DIDGAMDGNVCRCGTYQRIRAAIHEAARSLA
>A0A5Q4ZC85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia dioscoreae|TrEMBL
MTTLNINGQTHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDRKITTIEAVGSTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLLASNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGA
>A0A7W6DCB1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MTHILQPQSRALSRRSFLVTVGGLGIAVAFGRPPGLAYGADIAPSAQGDFRPNAWVTIAA
DGTVSIISPAVEMGQGITTTLPLLVAEELDADWNRVRVVQAPSDAETYGNPGFYGIQLTG
GSESTRGYNALLRLTGAQTRLVLLAGAAGMLNVPVKELETEPHKVVHPPSGRSLDYGEIA
ARAVLPDPLPQATEADLKPSDRWRYIGSRTILRIDVPSKINGTAVFGIDVQLPNMLFGAV
LRAPVQDERPETIDDAEARDVPGITHIVALPYGVGIIGETVEATKRAKDLLKVTWSTTSR
VRNYTSQRLLDEYRAVGRDLSQQGVPAHTNGDAEAAIAGATTVIEVDYMSDHVAHATMEP
MNATALVTGDRVEIWAPTQGPTGTQGFAAEIVGTTPDKVKVNTTLLGGGFGRKAEADFIV
DAVSLAKAVEGRPVKVIWSREDDVRHDTFRPLEAQHVKVGLDAEGNIVGWRHRIVADSIF
ARTLPPVFAEAGGHDDVVTEGAKFNYAVPAHQIEYLRQDKGLAIGFWFAVGVGYTRFAIE
CVIDEIAAARGIDPAALRLELLKDQPRARKVIETVARMAEWDRARDGRGLGLAYSDAFGS
HCAQVAEVSLNRDTGQIRVHKVWCAIDAGVAIQPLHIEAMMMTGITNGTGHALFEQINVV
NGEVQESNFDTYRVIRMSEAPEIEVAVVPTPGSPFGGIGQAGLPPAGPAIANAVARLTGG
LRLRHYPFTPERVKAALEA
>A0A7W6DB20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MSYAISVNGQVHHVEDDGQTPLLWVLRDTLKLTGTKYGCGAAQCGACTVHVDGQPMRSCT
LSLEVASSARIITIEAIEGADVRAIQDAWVAHDVPQCGFCQSGQVMSAIALLRATEKPTD
RDIDLAMSGNLCRCATYNRVRAAIHDAASKLGSPT
>A0A0P1IN46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cognatishimia activa|TrEMBL
MTMKVSRRGFLASASAAVLVLGVRPDGALAAGETDAMLNPFVKVASDGQVTGIVKHFEKG
QGPATGLSTLIAEELGVSIEQITYEFAPSNPEIYANTFFGGFQGTGGSTAMANSFMQYRQ
AGAAARELLIKAAADAWGVDASGLKIVEGIVTGGGKTAPIGDFVAAASTMEAPADPPLTP
PSEWRLIGNPDVRRLDSPIKTNGKAMFAMDLHLPNQMVAVISRAPSRGGLVAGFDDSACS
EVKGFIRAATLPNKAGVAVYAEDTWAAFQARDLLSVDWDMSAAETRSSDEIKSEIMAALD
EAPTYNVSKTDHAATKSAVDGAETVVEQTFYFPLLAHAPMEPLNCTIEANADGGVTLHDG
CQAPTGPHMALSQIFELPMEKVRINTMLAGGSFGRRATPDADYQVEAALAFVITDRKRPV
KLVWSREDDMRSGYYRPAVGHRVRVGLTGGKIVGWDHHVAGQSIMKGTAFEAMAVRDGID
HSSVEGTADGPYQIPGMFVGLTDTPKATSTLWWRSVGHTHTAYVMEVMMDQAAKAASADP
VEFRLAYLSGEGDDQKRKANVLRLVAEKANWGNAPEGRYQGVAVHKSFGTYVAEIAEISG
NPDDGIVIENVTCVVDCGIPVNPDVIKAQMEGGIGYGIGHVMRDQITLAGGEVEQYNFPD
YEPLRISDIRGIDVHIVKSEAAPSGVGEPGTPPSAPALANAIAAASGVMVASLPMEEEGV
YFA
>A0A7X0EDB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospirillum iridis|TrEMBL
MITFSVNGREQRFEGDPDMPLLWYLRDIQGLTGTKFGCGEALCGACTVHADGAPIRSCQT
TLGDLAGMAVTTIEGLSPDGMHPVQVAWRELNVAQCGYCQAGQIMSAAALLKDTPHPTDE
DIDSAMGGNICRCATYPRIRAAIKKAAGAVQRKTAGTAPVKAGSATK
>A0A0P7WZI5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium HLUCCA12|TrEMBL
MRLRVNDQTHELDLPGEMPLLWVLRDALNLTGTKFGCGVAACGACTVLIDGEAARSCQVA
LADVWGPVTTIEGLGSPEAPTPLQAAWNDHQVAQCGYCQSGQIMQAAALLAENPAPTDDE
IDDWMGGNLCRCGTYGRIRAAIHDAATRMQER
>A0A238JVS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas varians|TrEMBL
MASIGKIARRTFLFGSLAIVGGVAVGAWYVNKPAPNPLKPGPDEAALNPFVLINADGITL
IAPRAEMGQGTHTTWAALLAEELDVTLDMVTVLHGEPAQAYYNSALMGEGMNTKGYDDSA
LQHALASVMGKVGKVLNLQVTGGSTAMRDGYDRMRVSGAAAREMLKEAAAQQLGVKAKDL
KTENGTVIAPDGTTLTYIELAMAAAEIDPPKVKLRPQSDWKILGTSIPRVDIPGKSTGTA
KFGIDTRLPGMKFASVRMSPKRGGMKSYDDRDARDLPGVEKIVDMGDGVAVIANNTWLAM
QALQAIEIEWEDAPYEATTDAIFAKIEAGFELEPNSTLRDDGNTDALPEGATEVTAEYRV
PFLSHATMEPQNATAWFDGGKLRIWAGNQAPGFTQSACADEAGLDTDDVIVETTLMGGGF
GRRGELDFSVLATRVAKAIPGTPVQVTWSREEDMARDFYRPGAIARMTGGVKDGRAVMLD
ARVSAPSVTRQAMGRWMGFAPGGPDRSITDSLFNQPYGIPNYKVRGYLADTNPPMGFWRS
VGASFNGFFSEVFIDEMAQKAGVDPMEFRLGLTRDEWEPAYNVLAAVKEMSGWTGETPDG
IGRGVAMVYSFGTPTAIVIEVAEVDGDIKMTEAWIAADPGVALDPSIIEAQLFGGMAYGL
SAAIGEEITWDAGEVEQQNFPDYDPLRMQQMPKVNVRILETQEHIGGIGEVGTPPAAPAL
ANALFDLTGTRARSLPLNKEFSFFV
>Q88K16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)|TrEMBL
MQMLIINGQSQQVDVAPDMPLLWVLRDVLGLTGTKYGCGIAQCGVCTVHLDGQPIRSCVT
PISAVAGRAITTIEAIGETVVGQAVQQAWLAHEVVQCGYCQSGQIMAATALLQRQPKPDD
QAIDAAMAGNLCRCATYTRIRTAIHSVGQVEEA
>A0A7W5U631|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK612|TrEMBL
MTETSRNLVPEDEFPTGSPVNISRRHFLLTSAGAAAGAFVLGFGVPVGRARAQQAASPMP
PGTRVPAFLEIRPDSSIRFMSPFVEGGQGVFTAMAQIVGEELDADPKTFVVENAPTGSDY
LVVHGQMRITGGSMSVRTSYETMRRLGALARNMILQAAAKRLDAPITELTTEPGRVIHAA
SGRSLAYGDVASEALDLPVPAPESVTLRDPSKFRWIGKPVERLDIHDKSTGKAVYAIDCK
VDGMLHAAVQHAPRLGLTIGKIRNEEQLKAMPGVHSVHSLPGAVAVVAERWWNAKRAAEA
AQVDWREPGPDADPAFRYMPADFSTAAFNDRLANEPGNGKEAENVGDIAKAFDGAKTVVS
ATYRSQYLHHAQLEPPSTLARFNPDGSLELWMPNQAPEQFQADIAKLTGLDPSKVIIHSP
ILGGFFGRHFLYPSANPYPQAIQLAKEVGRPVKLIWSREEEFLRDPMRPMAAVRFRGALD
ASGMPVALEAISACEGPTEGVYGHKEDSLDPTALEGLAGKSYGIPNYRIAQIYVKNPTTL
AYWRSVGNSMNDFFYETFLDELADKGGQDPYELRLKLLQKNERLSNLLKAAGDLSGGWKR
GPFTTDDGSRRARGVAMASPFGSHTAAIAEVSIRNGQVVVHDVWEAIDPGSIVNPAIIEA
QVNSATALGMSQVLMEEAVYKNGEPVARNYDLYPILPPDRMARVHVRIVESGAEMGGIGE
PGLPAIPPAVANAVSTLTGKRIRSMPLSNYAFES
>A0A508SRE4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MGDIHSISRRAFVFGSAALAGGIAFGSYSSAEPAVTSGNGNPLAAGLGPNSVSFNPWVEI
SPEKITLIAQHVDIGQGVGSVQPIMIAEEMDLDPGQFEIRFAGPSPAYFNSGFADDFVPF
LAADQSPAAEAARAAELESLRKSGLQQTGGSSAVPDTYKKLRIAGAVARETLKVAAAKRS
GVPVADIRTQSGHVILPDGTKIPYVELSAEAAKIPPVLDVKLRDPSKWRMLGKPMTRLDV
RSKVMGELKFGIDLKMDGMMYASVKLNPNKGQPLKSYDASKARSMPGVKRILEVKNGVAV
IATNSWYAMKAVEAIDCEWAPSTYPAEQADHWKILEASFKPEFLGKEWRKIGDVDAGLKS
GRLIEAEYRAPYVAHQPLEPLNGIGIVSEAGMEIWVGHQSPQFVQSIAAAAIDLKPEQVT
FHNQWTGGSFGHRLEYENVRVLAEIANQMRGTPIKLVFSREEDFLQDIPRQIAIARHKGS
VDKGKIVAADLQLASTAPLKELLERSGIPSKEPDAQLASGLWNVYYDIPNFRATTYEAKG
LSPCTTWRSVGASTAGFFTESFIDELIHAAGLDPLKARIEMCAVPTYRKLLETLAEISDW
KGPLGNGKGRGVAFVEAFGTPTAEVVEVTMTDKGVRIDKVWVAVDVGKVVDPINFENQVQ
GGVVWGLGHAINCELTYAKGAVQQTNYNHHEAMRIYQCPVIEVRGLENDPKVRGVGEPPV
PPAAPALANAIFAATGMRIREMPFNKFIDFV
>A0A508U3C9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MPNLNINGRNMSVEAAADTPLLWVIREQLQMTGTKFGCGAGLCGACTVHLNGEAVRSCQT
SVADAAGKKITTIEGLSAKGDHPLQKAWIAEQVPQCGYCQSGQIMQAAALLSKNSNPTKD
EVVAHMDGNLCRCMTYSRIQKAIMRAASEMRTASATGTERRAT
>A0A7Y9HTT7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mucilaginibacter sp. E4BP6|TrEMBL
METNTVSRRNFLKVSSLAGTALCLGFYFPANAKKEQLISAIAAEQSAFEFNAWIRIDTNG
KVMLTDHRAEMGQGSYQSVPQIIAEELEVDMKDINVIFAQGDQTKYGSQITGGSSTIRGS
YKKLLKLSATAREMLITAAANQWNVPASDCYAESGHVIYKPSGKKLNYGELVTAASKFTP
PQEVKLKKTSEYKLIRKPLQRIDTPMKTNGEAIFGLDKRLPGMLFAVVERNPRLRGKLKS
FDDSAALKVPGVKQVFKVQMIVFNTTRDGVVVVADSTWAAMQGRKALSVEWDDSGFDHVN
TEDIYNAHQELLKTKDGLSFKKQGEPEEILAKAGKKIDVIYQTPYQSHSAMEPLNCIAHY
QNEKIEIWGPIQAPDWVQGDISDKFKIPKEKVIVNMTFLGGGFGRKAFLDYTHEAVAISK
QIGKPVQVVWTREDDLTQGPYRAGISYRGEGSIENGEISAVKFKMAGQNIDHWNGPARDK
ANGSTGEGFLTPYFDGIKNISFEDVPYEMPLPNMWWRSVYASTNGFAYESFMNEMAVLAG
QDQLDFRRKYLKDERCQALIDKMEQVSGWKNRRKNEGFGVAITECFETTVGQIVKVSRHS
DGKIKIDQVWAVMDCGWYVNPDIIKAQVEGSIVMALGAATIHEITFKDGLVEQKNFYAYL
MPRMTDMPPVEVHIMENTSDAGGVGEPGLPPFAPALTDAIYDLTGNRIMKLPFNLNAV
>A0A841IWP5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium subterraneum|TrEMBL
MDTATTPEPSSPKTRSKARTIGRRAFLVSSVVIAGGVAFGYYTVKKPHLNPLRDQLGPDE
ATFNPWVKISPKGITLITPHADIGQGVASMQAALIAEEMDLDFGQFEISQGTPSAAYYNT
ALAGETVPFLRNDHGIVAESVRTIADAMVKVMGMQSTGGSSSTIDSFVKLRTAGAVARET
LKEAAFKRTGIPVRDLRTASGAVILPDATKIPYTQLAGDAAKLSPVTDVVLRDPSQWRLI
GKKMERLDIVPKSTGTLTYGIDLDFKGMLYAAVKVSPRIGAARLGYDASKAKAMRGVKAI
LEIPNGVAVIADNTWRAFQAADAITFTWGKAPYPPDQDAHWAEVGRSFTKERLDKEWRHE
GDVDRALSGAKVIEAEYRAPYVAHQPLEPLSAVIKVTDGRADLWTASQAPGIAQQKAAEV
TGLPLENVHVYNQYAGGSFGHRLEFDHVKLAAEIGRQMKGQVIKMTFSREEDFTHDYPRQ
IAMARPRGTVKNGRVETCDLHIAAVSAARSYMSRLGTSIPGADLMLAAGAWDLPYKIPNF
RVTTYAVPELAPVSSWRSVGPSTSAFFADCFLDELIHAAGADPMEERLRLTDDPEARRVL
ETVARMSNWGSSLGPNRGRGVAFATTLGTPVAEVVEVWNTPDGIQIEKVYVAAEVGRIVD
PVNFENHVQGGVVWGLGHAMNCEITYADGMIQQPNYHVHEAMRLRQCPEIIVKGIETSAE
IRGIGEPPVPPAAPALANAIFAATGKRIREMPFNKHINFV
>A0A7U3ZI12|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MALFNLKINGKTYKTDVDANTPLLWVLRDHLDLVGTKYGCGMAMCGACTVHVNGEATRSC
VLPVSSVSNATITTVEGLSETGTHPVQEAWEEVDVPQCGYCQAGQMMTASALLAKNATPS
DKEIEEAMVGNICRCGTYHRIHDAVKLAATKMKK
>A0A7W6M966|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter noctilucicola|TrEMBL
MGRVKTIARRSFLIGSAAVLGGVAFGTYMYKREVDNPLEQGLADGEVTFNPYVRIDANAV
TLITPRADVGQGAYSIQAHLIAEELDVDLDAVRIEPGPPSAAYYNGVVAAEGMPIAATSE
TFLARTGRGASDVVGKLMGLQITGGSTTVPDMYDRLRMAGAVARETLITAAAQQTGLERS
TLKTANGAVILPDGTSLSYVDLAGTAAEMPVSDEVALRDPSTWRHLGKPHMRTDIVAKST
GTQDYGIDMRMEGMVHATTRTNPALGGGINSFDASAAENMRGVRAVLPITGGIAVVADNT
WRAFQAAQAVTCEWGPSPYIGETEKQFDEVASSFTEDRQDSRFKDEGDVEAALDGADVME
AEYRIPYLAHAPLEPMSVVVKLSDGRLDIWTGTQIPRFMQANAAKLTGLDADDVHVHVLM
SGGSFGRRLEDDYVSQAVEIAMQIRDTPIQMVWQREEDMTHDFPRPLAIARMRGAASSDG
IAAYDLSIAAPSVVASSMERLGQPAMGPDVAIVAGAWDQPFAIPDYRVTGYRVPPMVPIS
SWRSVGASGNGFLHECFVDEMCHAAGIDPLAERLRLCTHEPSRKVLEAVGDMSGWDMPLE
EGRGRGLAFVLAFGVPVAQVVEVTDMENGIRIDKVFVAADVGRVLDPVNFEAQLSGGVIW
GLGHAMNCEITYEGGVPQQDNYHVFEGMRLHQSPVVEVRGLENGDKIKGIGEPGVPPSAP
ALGNAIFAATGKRIRTLPFSNSVDFA
>A0A127MTH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas citronellolis|TrEMBL
MADLQQRASREPEDAGAGILNVSRRHFLRGAGGLALGIYFAPLLGRFGDPQAAAAKAFEP
NAFVRIAPDGTVTVIAKHVEMGQGSYTGLATLLAEELDADWSKVRVEGAPADAKRYANLA
FGTLQGTGGSSAMANSFEQMRKAGATARAMLVAAAAQQWKVPAEQIEVHDGVVEHKASGH
KAGFGQLAEAAAKQPVPAEVKLKAPEDFKLIGQVKLPRKDSQDKTDGQARFTQDVHLPDM
LVAVVAHPSRFGGVPAKVDDSKAKAVPGVVAVVQFPGSDSRFAGVAVLAKNTWAARQGRD
ALQVEWDESNAFRMGSAEIFAKYQELAAKPGVVARNEGDIAKALDKPAKLIEAQYQFPFL
AHASMEPLNCVVRLSDGACEIWNGEQWQTGDQMAVGQLLGIAPEKVSITQLYAGGSFGRR
ANPHSDYVLEAVSIAKAAREHGHKGPVKMVWTREDDTRGGYYRPAFLHNARLALDGQGNL
VGWEQHLVGQSFIVGTPFEKVMVKDGIDKVAVEGAADLPYAVPNLRVEQTLVPEIKVPTQ
WWRSVGHTHTAYSTETLIDEAAVAAGKDPYEFRRALLEKHPRHLGVLDLVADKAGWKQPL
KAGGEGEKRGRGIAVHESFGSFVAQVVEVTVKADKSFRIDRVVCAVDCGLAINPDVIRAQ
MEGGIGYGLAMALHSAITLKEGVVEQSNFHDFQVLRINEMPAVEVHIVPSSEAPTGVGEP
GVPPAAPALANALAAATGKRIRNLPIGNQLQA
>A0A833NA00|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter nauticus|TrEMBL
MAMNRRDFLKVSTSASGGLLLALNLPGCASVQTGYEPETGEWKPNAWLELTRDNDIIFTL
DRVEMGQGTYTGLTTLIAEELDVAPEAIRVAFAPVAPEYRNPLFGLQLTGGSTSVASSWQ
PLREAGASARLMLVMAAARVWRVEPGQCKTEGGYVRHPNGLDSMPYGKLVELADKEVIRG
DVPLKPRSQWKYIGRQAGRLDAEAKSTGQAMYGIDVELPDMVYAVMARSPRYGGLAVSFN
RDQVRAMPGVLDAFITERGVAVVADRYWRARKAQEALAVEWDFSEAVGLSNPDVFKHYRQ
AAGDDPGEDERVDGDPEAVLEKAGTLVEAEYEQPYLAHATMEPMNATAWYRDGGMEVWAP
TQAPDLGRIAAARHTDLSPDDVTIHTTFLGGGFGRRLTQDYIEEAALVAYRVKVPVKLIW
SREEDTRHGFFRPAMLHRMAASLEDGQLTGWDHQIVGPQILDWYVRNAAPAQYPWAPKLL
YGTLGRVGLMVEGIATPKDISAIEGAIGYPYAVPNVRVRHTHTDPGVPITWWRSVGYSHN
GFAVETFMDELANQANEDPVSFRLKLLESEPRHRRVLERAAELAGWNQPVPEGRARGVAL
FKSFGTYVAQVVEASIEQGGIRVHKVTCSVDCGQVVNPRIVEDQMTGGIVFGLTAALNGE
ITLDGGEVQQSNFHDYRLLHMHQVPEMVVDIVDSEEPPTGVGEPGVPPVIPALGNALFAL
TGKRQRRLPLKA
>A0A0S4HZ90|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGSVVGQNVTTIDNLHADPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPTD
AQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A7W9U465|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bannensis|TrEMBL
MTTLTINGETHTIDAPPDMPLLWVLRDIIGLTGTKFGCGIAQCGACTVHLDGEATRSCVL
PVAALEGRKITTIEAVGATPAGQKVQKAWREIDVVQCGYCQSGQVMSAAALIAQNANPTD
ADIDAAMAGNICRCGTYSRIRAAIKQAAKEA
>A0A448DUN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSLVDDSRIELPRREFLKQAATLASGLAIALYLPSGVGATDPKAPAQVKEFEPNAWVRVL
PDGTVKLVVHKHDSGTGTQTALAACVAEELDVNPMTVQVITPEDPFFETYIHPVWKVFST
GGSTSVSLEYDRLRMAGATARALLITAAAKQWKVSPQSCATEEGRVVHASSKRSLGYGEL
VGVAANLPAPDNVTLKDPAQFKYIGKLRHKRDAAAKVCGRFQYSIDVQLPGMLVAVIQRA
PVLGAKVVSVDSAAALRVPGVRKVLAVPGRPDVLGGNLEGVAVLADTYWAAQQGRNVLQI
QWSDSPLAGFDSDQLHAAQAAAIGDPHAQTVKAMSHGDVSGQWSSAAKLIEADYAMPYKV
QNPLEPICIVAQVKDRAITYWGGVQVPSSALEAAQIVCGIDKAKVTIHELVSGGSFGARE
AKYWLFEGAWLAQQTGVPVKLLNSREDEMHALFNHPATLHRVKGALDPQGKLTALQLHAV
SPASPEQWEPGYFERPDKMDYSTTEAITAWDFAYRPPHLELNWVKHESQLPSGWYRSVSF
IPNVFAVESFMDELAYAAGEDPLAFRLANMQERPRHVTVLKQAAERAGWGQPLPPGTALG
IATNQGYTSFIAVVARVATVNGKPQVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHAL
FDRLDIKQGRVVQSNFHDYRVTRMSDMPATDILVLDGEPGKPGGVGELGSPSVVPAIANA
LFALTGVRQRSTPFNLG
>A0A5E6Z3U3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGHKFAYAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMPGFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFEVAPSAIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARAPVFGASV
KSFEGAAALAIPGVHKVLQVPSGVAVVAEHFWAAKLGRDALKVDWDLGSLADMSSEKLLE
SFRKLAATPGTSATQAGDANTSFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAGKCEI
WTGTQFQTLDQMVASKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMP
VKTVWAREDDIRGGYYRSMYLHQARVGLGADGLPMSWQHVLVGQSIMAGTMLEATMVKNG
IDVTSVEGVADSPYIKDLAHHQVDLHSPKTGINVLWLRSVGHTHTGFVMESLIDELATAA
GKDPVEYRRTLLKAHPRHLGVLNLAVEKANWGAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLSMALHSKLTVKNGGVVQSNYHD
YQVLRLNEMPVVEVHIVPSSEKPGGIGEPGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>A0A5E7LUA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHSLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGSPARSCIT
PIGSVVGQNVTTIENLHTDPIGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPTD
AQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7N4A8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPSRSCIT
PIGSVIGQNVTTIDNLHADPVGQIVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7M1N0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIESDDVGKRVVATWVDLQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHAAVHELAGKGDA
>A0A5E7HQ32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLNINDKDLRVDVAPDTPLLWVLRDSLQLTGTKFGCGMSLCGACTVHLNGQPVRSCVT
PVSAAVEAKIVTIEGVGQTPTGKVVQEAWQRLDVVQCGYCQSGQIMSAVALLQTNPSPSD
SDIDRTMGGNVCRCATYVRIRAAIHDAAKSLA
>A0A5E7V7A5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVLVASWGWQDAFAEEKQKKFGADGMPHGWIDD
PKVYISIAADGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAMMKVQQAPGDEVRFGNQ
DTDGSRSMRHWFEPMRRCGAAARTMLEQAAAQQWKVPVSECRAQLHKVLHQPTGRELGYG
ALAAAAGALAVPARDSLRLKQPSEFRYIGKEGSRAIDGDDIVNGRAVYGADVYFEGMLFA
TIARPAVYGGKVKSFDASAAMKVPGVIKVIQIEDRPLPLEFQPLGGVAVVASNTWAAIKG
RDALKIEWDDGPHASYDSIAYRKELEAASLKSGKVVRNTGNIEEAMASADSTLEASYYLP
HLTQAPMEPMVAIARFKDGLCEAWAPSQAPQVTRERIGERLGIPFDNVTINVTLLGGGFG
RKSKPDFIIEAAILAREFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSAWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAIHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGREMPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKDVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRDLPVRYQLQGWQKAEA
>A4YQR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGV
TVSEAVGKHITTIEGLAGDNGLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSD
QDINDAITNICRCGTFAQVREAIHAAANA
>A4YZ38|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCIT
AISDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNENPKPSHD
QIRDAMSGNICRCGCYQRIENAVHLASTGV
>A0A7W6PW03|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium scionense|TrEMBL
MTRFTVNDRPVQYRMDPETPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCQV
TIGKTEGRFVTTIEALSPDRGHPLQQAFAAENVSQCGYCMSGIIMAASVLLRRTNDPTDA
EIDAAITNICRCGVYPRLRGAIKRAGRIMRGEDQAGDDPIQAAPPPGITPDEAVQAVPAL
RKP
>A0A7W6LN31|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium scionense|TrEMBL
MSRRTLLVGGGAAAGLVLAWAAWPRSYRPNLNVGPGEQVFDAFLKIDRAGQVIAIVPQTE
MGQGVTTILPQIMADELGADWRTVAVQSAPISPLYANGLLARDWLASDWTRVAGDAGNWA
IDQYATRSALMLTGAGTSVPMFHDAYRRAGAAARVLLCKAAAARWGVPWESCDIQNGIIT
DGAERKLRLGDVVEDAAGFTLPDILPYRQGNDGRLAGQDLPRLDTPSKIDGSHNFAADIR
LPDMVFASIRQGPIGDAVLKDARDAEAQKITGFLKLVRTERWIAAVGTNWWAANRALDLI
DPSFILRGTPVDSGRIDAALEDAFSGDAGRRLYVQGDLLPVFEKATILASEYQVDPGLHL
ALEPMCATARVTEEGTEVWIATQAPALARAAIADALGLSDSAVTLYPLHAGGATGRHLDW
EAGVQAALIARDVGRPVQLLWSRLEDVIQDRPGAPAHARMAAKLGRGGMIEGWLAKVAAP
CAMTQTWSRIAHGKLPHDAAADAGDKATRLAVAGMVPPYAIPNWAVDHYPADVGLPLGFM
RGNAHLHSAFFTECFLDELAHLAGIEAMSFRIQMLGGNPRLAHCLSTAAAMGGWQGGIAG
SGQGIAAHMMNGAYAAVMVEAGIEGNKLSVRRMVAAVDCGDQVNPDIARQQIESGLIHGL
ALAMGASVPYAAGMPTRAMLGRMNLPRLGDIGEVSVELIRSTADPAGVTDLGAPLAAPAI
ANALFTVTGQRFRSLPIMGNG
>M5F9L2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. STM 4661|TrEMBL
MARLTINGTSRDVEVDPDTPLLWVIREQIGLTGTKYGCGVAACGACTVHIDGVATRSCVL
PVSAVEPDQQITTIEGLSPDSSHPVQQAWLALDVPQCGYCQAGMIMAAASLLMQNPNPAD
EDINAEITNICRCGTYNRVRAAIKLAANGGEATQRG
>A0A840E3M7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lewinella aquimaris|TrEMBL
MATYNLTVNGTPRSVEAEPDMPLLWVLRDELGLVGTKYGCGIGACGACTVHLDGIAMRSC
SLPVGQLDGEAITTIEGLSENGDHPVQLAWLEHDVPQCGYCQAGQMMSAASLLGNSPGAD
DAEISASMSGNICRCGTYTRIHAAVKTAAKKMS
>A0A2K9Z2L9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium leguminosarum|TrEMBL
MITLNINGNQHEVDADPETPILWVLRDTLGMTGTKFGCGAALCGACTIHLDGEAVRSCST
PLSAAEGLNITTIEKATDGSDRVGAAVHAAWVKHDVAQCGYCQSGQIMSATAFLASLPSG
SQPTATEIDSAMEGNICRCGTYVRIRAAIADAASNLV
>A0A7W6YH16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium leguminosarum|TrEMBL
MLPNMDYSELPRALQHMLERGRSTPVQALPRRSFLKLTGTLGLAVGIFPHLAAAQPTDAG
EAPIALKPTEQPSAFVQIAPNGEVMVTINRLEFGQGVQTALPMILAEELDADWNLVRSQL
GTNDMAYVDPLFGMHLTGGSNTIKNSFTQYRELGARVRAMLLAAAADRWNVDVSALRTEA
GVVLAPDGRKLGYGELSEAAMALPVPQKIALKDPKDFRIIGQPTQRLDAQAKSSGQQSFG
IDFKLPGQLTAVVARPPVFGAKIASLDDSAARSVKGVKAVLRVLLDRGAEGVAVVADGYW
QASQGRNALKVEWDTSAVEKVDSEKQLAQFREIANRPGPRQFDADMAPLETAPLSLEAEF
VFPYLAHAAMEPLNCTVRLSDDRAEIWMGSQSAGLDAGVAANVLGLKPEQVVVNVQTSGG
GFGRRFSSSSDTAMEACQIAKAARSAGLNAPVRTLWSREDDMRGGYYRPTHLHRARIGFD
KEGNVLAWDHTIVGQSILTGTVFEKFQVKDGIDAATTEGMRSPYPLPMRLTVHHPVANVP
VLWWRSVGSTHTAFVMETLLDDIARATDQDPVAYRMKMFGNEHPRHRDALQLAVDKSGYG
SRTLAEGRAWGVAVHESFSSVVAYVVEASVVDGQPKLHRVTAGVHCNLAVNPRTVEAQVQ
GAAIMGLSTCLAGAEITLKDGIVEQGNFSEFTVARITDVPEFDVNIVPSADAPTGMGEPG
LPPLAPAFANAISRLTGKPVRQMPFNLT
>A0A7Y9WB48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLIGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDRKITTIEAVGSTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLLTSNPNPSD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGA
>A0A7Z0B084|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MRHDNEALTSARGAARRRFIKQSSALLASGLAIGFQLPEALAKGENASGDPQPSPGEFEP
NAWIRVLSDDTIKLVVHKHDSGTGTRTALAAVVAEELDVDPFRVDVITPENPFFGEYIHP
LWKVFSTGGSTSVSLEYDRLRRAGATARAMLIASAAKQWNVAPSALTTDNGFVVDPASGK
RASYGSLASVAAQLPAPKDVALKDPSQFKYIGKLQKKRSAAQKAMGAFPYSIDVSLPGLL
VATVTRAPVINARVRSVDAKDALAVPGVRQIVQIPGRPDILGGNQAGVAVLADDYWSAHK
GQAALRVEWDDSPLETFDSSALAAHQARWLDDPAARVVPTIQHGDAGTAWPHGARVIEAA
YSMPYKAQNPLEPINVTAWAKDGGIEYWGGLQVPSTVQEAAEVIGSIPTDRVVLHELVSG
GSFGSRESKYWLFEVTWLALKVGKPVKLMNSREDEMRALYYHSASYHRGKAVLDTHGNLS
TLQLRAVMPASPEQWEPGYFDRPDRMDYSTTEAISKYEFAYDAPHVDIGWVRHETGVPTG
WYRAVSYIPNVFAVESFMDEAAHAGKRDSVDFRLAHMKDPRHQAVLREAAARAGWGKPLP
PGTALGVATNQAYSSYVAVVARVKRNGDGVVIDKLTCVADCGLAVSPGGVEEQLYGGLMW
GLGHAIGDRIDIRHGQVEQKNFDTYRVMRMTDMPEIDIQIVQGDPAKPGGVGELSSPSVA
PAVANAVFRLTGQRLRDTPFDLGKVGAHAGAKVKVSA
>S9RZE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Litoreibacter arenae DSM 19593|TrEMBL
MTVNTSRRSFLKGAGAAVAVLAVGIDPKGALAASTSEAGTAITPFVKIYADGTVAAVIKH
FEGGQGTSTGLSTLIAEELNMELSDITFEMAPSDTAVYNNLFFGALQGTGGSTAMANSFM
QYRTAGAAARDVLLQAAAKDWDVDVSELTLANGVISGAGKEGQIGEFIATAAQIAVPAEP
VLKAPEDWTQIGNTQKARRDSHDKVNGEGIYGMDIQLDNQMVAAIKRIPQYGATVASFDD
SAAKDVTGFIMAKALPNGAGVVAYAENTWAAFQARDAIEVEWDLSKAETRSSDEIKQQLL
AAVNTEPQWQASETTLGAASTALEGAAQVVEREFFLPMLAHATMEPLSATIAATEDGGVI
MYDGAQGPTINHATMHQILGIPMDKIQVKTLYAGGFFGRRFNAGADYIVETTLAFSMTDQ
TRPVKLVWSREDDLAGGWYRPAYAHKVRVGLDDAGKIVGWDHRVAGQSIAKDGPFEAFYV
KDGVDISSVEGTAENPYAIPGMHIGLTDAAPATTVNYWRSVGHSHNAYVMETMMDVAAAA
AGQDPVSFRLAYLPGDTADQKRKADVLKLAAENAGFGKPLPDGHFHGVAVHKSFGTYCAQ
ICEISIDEDDYVQIEKYTAAVDCGVAVNPDVIKAQVEGAIGFGVGHIMRDQITLDGGVVV
QQNFPDYEPLRMRDIKAIEVHIVKTNEAPSGIGEPGTPPAGPALANAIAASGRDLVTHLP
MTENGVEFA
>A0A7W5LKI7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK313|TrEMBL
MLTLNINGQPQEVDVPEDMPLLWVLRDHLNLVGTKYGCGIAQCGVCTVHVAGKPVRSCQL
AVGDVGTRAVVTIEGIGNTPNGAKVQQAWMEAAVPQCGYCQAGQIMSATALLDSNPQPDD
SDIDAAMAGNLCRCGTYIRIRRAIKNAATKPA
>A0A375F1Q6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLEMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGADRVGRAVIDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A0F4SZW5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGIAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A0B7D6P6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A5E7H2J5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PATTVAHGQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>B1FVK5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MKRRTFVIGGAGAVGALLVGWSVLPARQRLTTDAPLPVEGTQTALNGWVKIAADNSVTIM
MSKAEMGQGVHTGLAMLLAEELDADWSRVRVEDAPIDNIYNSVQNVIDDLPFRPDHDSIT
KRAVVWYTRKLTREAGTMMTGGSSSINDLWTPMREAGASARAMLIGAAAAQWHVAPGECA
TQGGYVTHPSGHKASFGELSSMAAQQPLPRKVALKNPANFTLIGKPLRRIEAASKINGSA
RFGIDVLPDGLLYASVVMCPTLGGTVASFDASAAQRMRGFVKALAFEPYAGGTGGVAVIA
DNPFRATNAVDAIKVTWQHGAAATLSSAEVERRLALALDDGDGHAYYRRGDINDALSGAA
RTITAEYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQTPALARRHVAKVLHIDDDKVHV
HAQLLGGAFGRRLETDYIAQAAAIAREAGGRPVQTLWSRAQDFTHDFYRPACVSRLKAGF
DDNGKLVAWHSASASQAIVPEALARYYGAPRIPLDKTTAEGAFDQPYEWPTARVAHKIVD
LPVPVGFWRSVGHSHQAFFTESFTDEIAAATSQDPIAFRSALLAQHPRHLAVLQRVAALS
DWTHPLTSAADGAPRARGVALHEAFGSVVAQVAEVSIGPHRMIRVHRVVCVIDCGLPVNP
NLIRQQMESGIVFGLSAALQDEITIVNGQVEQKNFVDFPVVRINDCPIIEVDIMPSQLHP
QGVGEPGVPPIAPAVANAVFALTGKRLRTLPLKFT
>A0A4Y8AB90|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mucilaginibacter phyllosphaerae|TrEMBL
MSTGTLSRRDFLRAGGITGAALCLGFSFSSDGKEAKVIVAADADRQAIEMNAWIKIDADG
KVTLVDHRAEMGQGSYQSVPQIIAEELEVDLKDIQVIFAQGDPKKYGGQITGGSSTVRDS
YKKLLKLSATAREVLIAAAAAKWQVAATACYAQAGHVINRSSGKKFHYGELVAAASKLPA
PQNIVLKKRSDYKLIGKPLHRKDTPLKTNGAAVFGLDKKLPGMLYAVVERNPRFRGKVKS
FDAVAAKKVAGVKDVFTVKMEVFNTIREGVAVVATSTWAAMQGRKALKVVWDDSGFEHIN
IADIYTRQQQELKKEGISFKKQGDPDSALAQAANALDVVYQTPYQAHSAMEPLNCIAHYQ
KDKVEIWGPIQAPDWVQGNISQKFGVPIDNVRVNMTFLGGGFGRKAFLDYPYEATMISKH
IGGPVQVVWSREDDTTQGPYRAGVSYRAQGAITNGEISAVKFRMAGQNIDHWSNPKRGVA
NDSTTEGFLAPYFASIKNISFADVPFEIPIPNMWWRSVYASTNGFAYESFMNELAHQAGK
DPLAFRRVYLKDDRCQKLIDKMEEISGYKDRKKGDGFGVAITECFGTTVGQVVKVSRENG
GKIKIDKVWAVVDCGWYVNPDIIQAQVEGSVLMALGAATMHEITFKEGVAEQQNFYNYPM
PRINDMPQVIVHVIDNDADAGGVGEPGLPPFAPALTEAIFDLTGKRIRKLPFDMANV
>A0A2N7WBL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia rhynchosiae|TrEMBL
MKRRTFLVGGAGAVGALLVGWSVLPVRQRFTTVTPLPVQGTQAALNGWVKIAADNTVTIM
MCKAEMGQGVHTGLAMLLAEELDADWSRVRVEDAPVDNIYNSVQNVVDDLPFRPDLDSVT
KRTVVWLTRKLVREVGTMMTGGSSSINDLWTPMREAGAAARAMLIAAAAAQWHVPAGECT
AENGYVMHPSGHKASFGELSSLAAQQPLPDKATLKDPANFKLIGKPLRRIEAASKINGSA
RFGIDALPDGLLYASVVMCPTLGGTVTSFDAASAAKMPGFIKALSVAPYNGGTGGVAVIA
DNPFRAMNAVDAIDVTWQHGAAASLSSAEVERRLALALDDSDGHAYYHRGDVNDALSGAA
RTIAAEYHAPYLAHGAVEPLNCTVHVADGAATVWVSTQMPALARHHVAKVLDLDDDKVHV
NAQLLGGAFGRRLELDYIAQAAAIARQAGGRPVQTLWSRAQDFTHDFYRPACVSRLKAGL
DKNGKLVAWHSASASQAIVPEALARYYSAPRVPLDKTTSEGAFDQPYEWPAARVAHKIVE
LPVPVGFWRSVGHSHQAFFTESFTDELAAATGEDPIAFRAALLAEHPRHLAVLKRVAALS
EWEHPLTHAADGAPRARGVALHEAFGSVVAQVAEVSIGPHNRIRVHRVACVIDCGLPVNP
NLIRQQMESGIVFGLSAALQDEITIVNGQVEQKNFVDFPVVRINDCPVIETDIMPSQLHP
QGVGEPGVPPIAPAVANAVFALTGKRLRTLPLKLT
>A0A0G3CML3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pragia fontium|TrEMBL
MASSRAIKVNGQWIRLENTPPTTPLLYALRNDLMLNGPKYGCGLGECGACTILIDGVATR
SCITPVSAAYQKEVTTLEGIGTEQDMHPVQQAFVEEQAAQCGYCTNGMIMTLVALFERNP
NASEDEIKQELTYNLCRCGTHMEILSAAEKAKALLAERKTA
>A0A117ZUM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cepacia|TrEMBL
MITLTVNGVRHTLDIDPSTPLLYALRNDLHLHGAKFGCGLGQCGACTVIVDDKPMFSCLI
PVSALGERRVRTVESLGSAAHPGKLQQAFIDHQAAQCGYCIAGMIMRAQALLERNPKPTE
RELRTQMEPNLCRCGTHMRILAAIRQVAGLPDPEPAAAPVMISKGL
>A0A853SRA0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. HH102|TrEMBL
MITLNINGRDTQVDADPSTPILWALRDNLNMTGTKFGCGAALCGACTVHLDGQPIRSCIT
PISSVGAQKITTIEAMENDQVGKAVQAAWVRHDVPQCGYCQSGQVMSATALLRTNKAPSD
ADIDGAMSGNICRCGTYQRIRAAIKDAAKTLA
>A0A2A5QBB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Providencia rettgeri|TrEMBL
MQLNINGRWVELSNISPSTPLLYVLRNDLKLNGPKYGCGLGECGACSVLIDGKVVRSCST
PISTVENRKITTLEGISDADTLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFKRNPNASE
EEIKKELAFNLCRCGTHVEILKAAKKAKIIIAQGGKA
>A0A1L3LVM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium americanum|TrEMBL
MAIVTINGVEHSVDAAADMPLLWVIRDLVGLTGTKFGCGMAQCGACTVYVDGSPVRSCQT
FIGDIEGAQVTTIEGLKGKVAEAVQAVWADLDVPQCGYCQSGQIMSATDLLANNPKPTDE
DIDAAMSGNLCRCATYHRIRAGIHEAAKRLEG
>A4FDX8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)|TrEMBL
MTTHAPSPLPAESGEPALVGRRRFLGYVLAAPTLVAAAELGPGSGTAGAAVPSAPSPAEI
YDLNDMLTEAALPTANLITVEVHEDGTVSFALPRAEVGQGITTSTAMLIAEELDVPLERV
RVTLADARPELLFNQLTGGSNTTFATYTPIRVAAAIAKGRLLRAAAIELDAAVTSLTTRA
GMITSAAGLSTTYGALARKAASLRTEEVAVELKPRSEFTVIGTPRNRVDALAAVTGRKKF
TMDLDVPDALPTMVCRPPTINGTVESVVNAAEVRTMPGITDVVAVSTGVAVRGRTFGQCI
DAVRALRVKWGPGSAEGKSDESVLEELRAAELPMAVPKTGPLTRTIEEEFTFHFRGNSAL
EPNCAIADVRADRAEVWAALKSPVVAQETIAARLGLPPGAVAVHVVEGGGSFGRKLFGDA
ALEAAEISQRMGKPVRLMWHRADDCRQGRTHPMATSRVRVSLTPDAVLGYEQRHTSVFTD
FGHGLGEVVTAMAAKLPVADLGFSETIFALSQTMPYEFGTTTQLLNETDKGFNTGSMRNI
YSPDVTCARELIVDRLAAEMASDPYRFRRDFLQDDRSRAVLDEVARAGGWGRPMPAGTAQ
GIAFHAEYHGVTAALVEIDCRPETVNRPIRDGVTGPRVTKAVFAVDVGLAVNPRGLQAQM
MGGISDGIAQVLTSSLHLRDGHFLEASWDNYFYTRQWNTPFELEIIVMPPTTGEPGGAGE
LGVAASMAAVACAYGRATGTTPTSFPVNHGTLSFEPKPAVPPIPQSPVDGLRHTY
>Q399V6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MIDIVVNDTRHSLENVPEDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHLEGQAVRACL
IPAVAAHGRHVTTIEGLSPDGRHPLQLAWVAEDVPQCGYCQPGQLMQAAALLKGGQPVDD
DAIVQAMSGNICRCGTYARIHRAIKRAASGDPALKAAAEPAKEA
>A0A061CXS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas oleovorans|TrEMBL
MITLNLNGKDHELDVADDMPLLWALRDVANLTGTKYGCGMALCGACTVNVEGQPTRSCVT
PVSAVVGKRISTIEAVGEDAVGKVVQDAWRQLDVVQCGYCQSGQIMAATALLNSNKAPSD
ADIDAAMSSNICRCATYVRIRAAIHEAAGKLT
>A0A142PGP8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MRFMLNGQPFDFDGDPDTPLLWVIRDSARLTGTKYGCGIGACGACTVHLDGEAARACVLP
AASVAGRAITTIEGLSHDRSHPVQRAWIEKDVPQCGYCQSGMVMATAALLARHRKPTDAQ
IDAAVTNLCRCATYQRIREAIHVAAG
>A0A144TU76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MITLTVNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRACIT
PVAAASGKRVTTIEGLSTDLTHPLQQAWQELNVAQCGYCQSGQIMQAASLLKTNPHPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAVRRGGAA
>A0A841EM34|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arcicella rosea|TrEMBL
MTQNNSRRKFIKASTMLAIGFSLPSIGKAESLHKIDTSSASALGIELNPYILINDDGKII
LFNARPDMGQGTYQSLPLLIAEELEVTLDQVEIRNTDGQGKYGAQLSGGSSSVRTRWLPM
RKAGAAVKEMLITAASKKWQVPVSECYASAAKVFHKPSGKSYTYGELVEEASKLEIPKEP
KLKDQKDFKLLGKSVPRPEIPSKVNGTAVFGIDSDIPGMLYASIERSPTIHGKVVSFDGS
AAMKVKGVKYVVKTERKMPHKAVEAVAVIADTYWAALKGRRALKINWDAQGSDKISTDAY
FENLRALAKTEGIEYKNEKVGDFNKGFESATKKVEAQYETPFLAHAPLEPENATVWVQGD
KVEIWAPIQGPDGLIPQVAQYLKIKPENVKVNVPFMGGAFGRKAYFDYVLEAANLSKQVN
APVKVIWTREDDTTQGPFRPGMLSAMQGGLDDKGNIVAHNHKIVGSSIQHQVFGNPLKNA
PDDWAIETANTEDSPYDFASRKASFHLAETDIPILWWRSVYSSTTAFGQESFMDELAHAA
KTDPLAFRLDMLADASRFSRVLQTLAKKANYHQKLPEGQATGIAIARSFGTIVAHAVTVS
KSGKGVKIEKVVSVIDCGMTVNPDNIKAQTEGNIVMGLTAAIKNGITFKDGQAEQSNFHQ
YNVLRFNEMPATEVHIVDNQELPGGVGEPGLPPFAPALCNAIYNLTGTRIRTLPFDIDNI
G
>A0A6S7D1Z7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pararobbsia alpina|TrEMBL
MRTYSAIGEDALPDNARRRFLTAGALLVGFAFVRPVRAFEREPDLAAIGALDATATGFDG
FVPDGFIRVGVDGRIVLVVPSVEMGQGIATGEAMMIAEELEVGLDQVEVALAPADQHAYT
QSMLKAQATGGSTSVRAYFIPLRQAGAAARTMLIGAAAERWRVPPAECAVARGVITHQRT
GRTLTYGAVASAARRQPVPREVSLKPVSQFKLIGRAAKRVDTPAKVNGTARFGIDAMVEG
MRVAAIAMCPTIGGRLRSLDERASRVLPGVVDILRIDDAVAVVAEHYWTAKRGLDLLRIE
WDEGPHATLTSATLAESLRSAQGTPINGSLTGDPDHVIQEAGKQRIETSYDLPYLAHAAL
EPINTTIHVRPDGCDIWVGTQVPEIARIVAAEIIGLPPDKVIVRNHLIGGGFGRRLAVDT
IQQAARFGKQVGYPLKIIWTREQDIQHDRFRPAYLDTIAAALGKDGLPMAWTHRTRCSTV
RSYYDRKPWPQGQLDHDAVAGAADLPYAIPALRSEWVRQDGPVALNWWRGVGETHNVFVV
ESFLDELAHAAGQDPVAYRRALLGKNPRSLAVLNKAAQASGWGKPLPPRCARGISLHESF
GTHAALVMEVEVDPQGEIHLRRATAAVDCGIAVNPDSVIAQIEGGVLFGLSAALYNGITF
ENGRVQQSNFHDYRQIRMNEVPPFEVSVMPSEEKPGGLGEVGTVSAAPALANAIFAATGV
RLRALPIDRRALGAKGKQL
>W6VN55|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. GM30|TrEMBL
MSLRDDTLLEPSRRVFLKQAATVASGLAIALYLPSGSAASDPKAPAPATEFEPNAWVRIF
PDGTVKLVVHKHDSGTGTQTALAACVAEELDVNPMTVQVITPEDPFFDTYIHPVWKVFST
GGSTSVSLEYERLRMAGATARALLIAAAAKQWKVGPDSCSSEEGRVVHLSSKRSLGYGEL
VGVAAHLPAPANVTLKDPAQFKYIGKLRHKRDAAAKVCGRFKYSIDVQLPGMLVAVIQRA
PVVGAKVLSVDSAAALQVPGVRQVLAIPGRPDVLGGNLEGVAVLADTFWAAQQGRKVLEI
KWSDSPLAGFDSAELTKAQAAAISDPHSQSVTAMTHGDVDAQWPHAAQLLEADYRMPYKV
QNPLEPICITAHVKDSAITYWGGVQVPSSALEAAQTVCGIDNGKVTINELVSGGSFGARE
AKYWLFEVAYLAQQTGVPVKLLNSREDEMHALFNHPATLHRVKGALDAHGQLSALQLHAV
SPASPEQWEPGYFERPDHMDYSTTEAITAWDFAYRPPHLQLNWVKHESNVPSGWYRSVSF
IPNVFAIESFMDELAHAAGADPLAFRLANMQERPRHVAVLKQAAERAGWGQPLPPGTALG
IATNQGYTSFIAVVARVATVDGKPKVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHAL
FDRLDIQQGRVVQSNFHDYRVTRMSDMPATDIVVLDGEPGKPGGVGELGSPSVAPAIANA
LFALTGVRQRSTPLTLG
>A0A485EDM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MNSKIDLSNALPRLAPRLPQRRRGGRPDHRFQWSGARRALAAALPDAGFAPNAFLRIAPD
DSVTVIAKHVEMGQGAYTGIATIVAEELDADWSKVRVESAPADAKRYANLAFGTMQGTGG
SSAMANSWMQLREAGAKARAMLVEAAARQWRVPATELRTRDGFVEHPASQRKASYGSLAA
AAAELPVPEKVQLKDPKDFRLIGHQAPRVDVPGKTDGSAQFTLDVSLPGMLVALLQRPPL
FGATVKSFDATATRAIPGVVEVVQVPHGVAVVAKGFWAAKQGRDALKVEWDESKAEKRGS
EALMAEYRKLAEQPGKPARRDGDAAKAVAGATRRIAASYEFPFLAHAPMEPLDAVVRLTA
DSCEIWAGDQFQTVDQGNAARTAGLKPEQVKINTLYAGGSFGRRANAWSDYIVEAVSIAK
ALGANGVPVKLQWTREDDIHGGFYRPMYYHRLEAGLDADGKLVGWQHRIVGQSILEGTPF
AAVMVKDGVDATSVEGAANLPYAVPNVSVELSTTQVGVPVLWWRVVGSSHTVYAVEAFID
EAAQAAGKDPYLFRRDLLAEQPRLRGVLELAAEKAGWDPSRPLPAGGGRGIAVTEAFKTF
VAQVVEVSVDKDGKLKVERVVCAVDCGIPINPDVIAAQMEGGIGFGLGAILHSAITLKDG
KVEQNNFDGYQVLRIAEMPKVEVHIVPSGEAPTGVGEPGVAPIGPALANAIFAATGQRLY
NLPFPTSFAKA
>A0A6J4PY11|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Rubellimicrobium sp|TrEMBL
GGESDRRRTGTGAEPAAAASPGDRAALLLCDRADGGLCPDAASGSGGRDGWGHAVRAGRH
DGGGRGDEPPSGPRRAAAGLSLAGPRPVGRGACGRGPCGRGAAACAGRPAGRAEAASGGL
>A0A7W8L2X8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia youngii|TrEMBL
MTNLLDSPSEQFPIEEQPRNISRRRFLLASVGTAAGALVLGFGLPVGRARAQAAANSAPG
TNVPAFLEIRPDSTVRLQSPFIEGGQGVFTAMAQIVGEELDVDPATFIVDTAPPGRQFQV
MDIGTRFTGGSMSVRSSYPTMRRLGALGRAMLLQAAAQHLRVPVGELTTQPGRVIHASSG
RSLSYGELATSAMDLPVPQPDSVKLKNPSEFRWIGKPMGRLDVHEKSTGKAIYSIDVRVD
GMLHAAVQHAPRLGMTVGSIRNESQIKAMKGVHSVHRLPGAVAVVAERWWNAKRASEAVQ
VEWHEPGPESTLRYMPADFSTQAFRDRLATEPGSGDTAETIGDVSRALKDAHTTVTATYH
SQYLNHAQLEPPSSLARFNADGTLEVWLPNQAPDLFLADMAKRTGLDPAKITIHSPLLGG
FFGRHFIYNTASPYPQAVQLAKETGRPVKVIWSREEEFLRDILRPMAVVRFRAGLDENGM
PVALEAVSATEGPTEGIANKRDTKLDPTALEGLTGKAYKIPNRRIAQLYVKTPVMLGYWR
SVGNSHNDFLYETFLDELADKGGHDPYDLRMRLLQGNQRLTHLLSAVAELSGGWKRGPFT
AEDGTRRARGVAMASPFGSQTAAIAEVSIENGHVKVHDVWEAIDPGSIVNPAIIEHQVSG
AAALGLSEVLLEEAAYKKGIPVARNFDMYPILPPARMARVHVRIVESGAKMGGIGEPPLP
AVPPAVANAVSRLTSQRVRSMPLSQYNFKA
>F4CF32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium sp. (strain 21)|TrEMBL
MTATKLNINKKTYTLEVDPSTPLLWVLREHLDLVGTKYGCGVASCGACTVLLDETAVRSC
SLPISAIGDKAITTIEGLSEDGDHPLQQAWEQHDVPQCGYCQAGQIMNAAALLKSKPNPT
DDDIDAAMTGNLCRCGTYLRIKAAIKTAANY
>F4C662|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium sp. (strain 21)|TrEMBL
MAKYSILVNDKTYEVDVMDDMPLLWVLRDVLGMRGTKFGCGKALCGACTVNLDDTAIRSC
SFPISAVGKGKITTIEGISDHGDHPVQKAWEQYVVPQCGYCQTGQIMNAVALLKSNPRPS
EQEIEQAMQGNLCRCGTYNRIKTAILSIAGA
>A0A7W5DAE6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. Sphag1AA|TrEMBL
MTIGINLNGKLVQVKSEPDTPLLWVIRDEIGLTGTKFGCGAALCGACTVHLDGVAVRSCQ
TPVSVAAGRKVSTVESLSRNNTHPLQKAWIAHDVPQCGYCQSGQLMSAAALLSTNKNPSD
ADIEGAMSGNICRCGTYGRIKAAIKSAAAEMRRA
>Q13NR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia xenovorans (strain LB400)|TrEMBL
MSQGLLDAQNGAEPSKAGARAAGGLSRRTFLKFGVTVGAAAGGGLLLGFSMPAASQDQKA
GKSVIGGDGVETPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LDTVTVDHAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRKAGATARTVLISAAAQQWQV
DPASCHAQAGQVIHAASNRSIGYGQLVTAAASLPAPQNVKLKDPKDFKLIGTAVKRLDSP
EKVDGTALFGLDVRVPDMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQVIKIDNAVAVI
GDHTWAAKRGVQALVIKWNEGAGANLSMKQIVDDLANASQRNGAVARKEGDVANAFSNAK
TRVDAVYQQPFLAHATMEPINCTVHVRPDGCDVWLGSQVPTRVVDAAVAVTGLPADKIVV
HNHLIGGGFGRRLEFDMVTQAVKVGKQVSTPVKVVWTREEDIQHDMYRPYYYDRISAGLD
ANSKPVAWQHRIVGSSVIARFAPPAFRNGVDPDAVEVASDLPYDLPNQLVDYVRQEPHAV
PTAFWRGVGPTRSTFVVESFIDELAAQAKVDPVKYRQDLLGKTPRALNVLNVATQAANWG
SAVPKGQGRGVSVMHAFGSFFGIVVDVAVDQGEVAVKRVVCAVDCGMVVNPNTVEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIEVHIVKSSEAPGGIGEPGTA
ALAPALTNAIFAATGKRLRQLPVGSQLQTA
>K0PYP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium mesoamericanum STM3625|TrEMBL
MVTFTLNGHKKTFDGDPDTPLLWVIRDFEKLTGTKYGCGVAQCGACTVHMDGFSRRSCVT
PISTAEGSEIFTIEGLEGKEAEAVKAAWIAIDVPQCGYCQSGQIMSAVSLLQNIPKPTDA
DIDGAMAGNICRCATYHRIRAAIHNAAASMEG
>I0HRM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubrivivax gelatinosus (strain NBRC 100245 / IL144)|TrEMBL
MHPLIREMEARAARQARGPTRRTVLKAGAGSGLIVLCGACSTPPAVPRTGGVAADGTGTG
PFAPNAFVRIGSDDIVTIVCKHHEMGQGNMTGLASIVADELDADWARVRAEQAPSNAKLY
NNLAFGPMQGTGGSSAIANAYEQMREAGATARAMLVAAAAQAWGVDPAEIRTRASVLSHA
SGRRATYGEMAEAASRLPLPDKPALKSPAQFVYIGKERGAPRVDSPSKCDGTAVYTSDVK
LPGLLTALIAWPPSFGARLVSFDASAARQVKGVVDVVQVPEGVAVVATGTWAALQGRRAL
VVQWDESAGRALDSDALLASYRAQAARPGLPFTKPAASQSAAAGVKTVDAVYEFPFLAHA
TMEPMNCVAWLHDGQLDTWSGHQFPSLDHQFAAQAAGLPMERVHLHSVLSGGSFGRRANG
AADFTVAAVHVAKAIGGRAPVRLQYMREDDMGAGYYRPLVLHAVRASVDGRGRIADWSHT
IVGQSIMAGTPMASMIKEGIDETLVEGVHPSAYDLPMLRGQAHMPVLPVRPLWWRSVGNT
HTAFVMETMVDELAEAAGRDPLEFRLKLLHRSPRAAGVLRLAAEKAGWGRAGAPGSALGL
AVHESFKSFVAQVAEVSMRDGKLKVERVVCAVDCGLAVNPDVVRAQMEGGIGFALGALYY
GEIELRGGRAVQRNFDGYRSLRLHEMPRVEVHIVPSPEAPTGVGEPGVPPLAPAVVNAMA
RLGVPRVRRLPLSRGHFVAT
>I3X4S5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MLPKLMQSVTLPAARVEASRRQFLIGALATGTGLAIGFRLLSASPAAASETATTHGSHAF
SPYLTIDGDGTVTVLSSQFEMGQGSYNGIATLVAEELDADWSTIDVKGAAGNIKAYGNIA
FGGTMQGTGGSTSMVTSWERYRKAGAAARAMLVAAAASEWGVDSAEIAVEKGVLSHPSGK
NGGFGVFAAKAATMPVPPDVTLKQPSDWKLIGNSELKRFDSARKANGTEQYTIDVKLPGM
LTAVIIHPPLFGAKVKSFDAAAARAIKGVVDVVETPRGVAVVGENMWASIKGREAVTVEW
DEAGAEKRGTQQLMSMYRDLVKKPPAAVARKDGDAEAEFAKAAKVIEASFEFPYLAHAAM
EPLNAVARMNEDGTLEIWGGHQFTDVYQKLAGDAAGIAPEKVRLHVMKTGGSFGRRAVFD
GDVVVEAVHVAKAIGFRAPVKLQWTREDDMRGGRYRPAYVHSLKAAIDDGGKLVAWNNHI
VGQSIVAKTAFEGMVKNGVDPTSVEGASNLPYTIPNQTVGLTSTEVGVPVLWWRSVGSTH
TAFAAETFLDEVAEAAGRDPVEFRLSMLEPESRHATVLKLVAEKAGWQKPLPEGRFRGVA
IAESFGSVVAEIAEVSTDGKGQIKVERVVAAVDCGLAINPDQVRAQVEGGIGFGLSAIFG
EEITLTDGKVDQGNFDLYTPLRIDAMPAVEVHIVASANPPSGIGEPGVPPIGPAVANAAY
KALGKRIRVMPLAKSLNA
>A0A448TSS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinobacillus delphinicola|TrEMBL
MITVSMTINNKKVGPIEVPASLKMIEFLHEYLSLTGTKFGCGAGICHACTIIVDEKDGTS
HTMRTCINGVGDFNGKVLRTIEGHAKRNALGQITALSPVQETFIKHFSFQCGWCTSGFVN
EATVLVEDLKKNPIEKDQIEARIEDALKDHICRCTGYRKYYVGLRDLILSQGGLVK
>A0A0M2WRS1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. KBS0711|TrEMBL
MYNITVNGQPFGTETDAETPLLWVLRDEVKLKGTKFGCGIGMCGACTVHVDGRAMRSCIT
PIAAVAGCAITTIEGLSPDGTHALQRAWLATQAPQCGYCQSGQIMQAATLLKDYPQPTDA
NIDAVMSGNLCRCMAYVRIRKAIKLAAGMQEAPGV
>C1AED9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)|TrEMBL
MVSVPFDRHFLRMRRRAFLLAGLGTGGALFLGWTLLPPRQRLQGRHAPEVPAGSGIVALN
GWLTIAPDDTVTIVAPKAEMGQGIHTALAMLVAEELDCDWQQVRVTHSPIDRIYGNVAAL
VDGLPIHPDQLDAPLVRGVRWLTAKVAREIGVMMTGGSSSVRDCWMVARQAGATAREALL
SAAAEQTGVPIAECRTERGVVVCGTQRLRYGSLISAAVRQRPSRVVLKTPSQFTRIGVST
PRLDARDKVQGAPLYGIDVALPDMLYAAVAMPPVLGSRPLHFNQQAAMARPGVRAVVALE
GTRYGDPPGVAIVAESWWQARQALPALAIEWSPSPHAALSSDGIMSTLRERAMRGDAFAF
RRSGDAEALVNAPGARVMESLYEAPYLAHAAMEPINATARISRDQAEIWVGTQVPGFVRD
AVAHVTAIDPSRITVHQYQLGGAFGRRLEADYAAQVAMIARAIPGVPVQVIWTREDDMRA
DFYRPAAVTRFRAALSPTGNVRAIVVQSASQAPFKALSQRVGFVPTMRGPDRTMAEGTWD
QPYEFPAVRAAHAEVSLPVPVGSWRSVGHSHQAFFLESFIDELAQQAGQDPLAYRLALLA
RHPRAATVLRRATDAAGWNTPIARGDDGLLRARGLALHWSFGSYVAQVADVSIDGAQQLR
VHRVVSAIDCGLIVNPAGVTQQVESAIIYGLSAALHGEITIENGRVRQGNFHEYRPLRID
ECPVIETHLIASSEPPSGAGEVALPPVAPAVGNAIAVLIGRRLRQLPLRLTSRAVRGGAG
T
>A0A6J5ESR5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia humisilvae|TrEMBL
MSTTFILNGQSTTLDADPNMPMLWAIREVAGLHGTKFGCGMAQCGACTIHLDGQPLRSCI
TPLSAVSGRKVTTIEGLQGKPAKAVQAAWVKLQVPQCGYCQSGQIMSAAALLTENPKPTD
ADIDAAMSGNICRCATYTRIRAAIHDAAHSMEA
>A0A482ZSJ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MRIDLSRLHLPCVWVGRLSGCDLRIDLSRLHFGFDVTAPAFRCDLRIDLSRLH
>A0A482ZUC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MQIDLSRLHSREVMNKYGVSCDLQIDLSRLHLRYCSELCLSSCDLQIDLSRLH
>A0A482ZSK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MRIDLSRLHFIPFWAVVFWGCDLRIDLSRLHYIQLLKYCHLRCDLRIDLSRLHSKHLLHR
CVFVVICG
>H0TE08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MANLTINGKSFTLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHMDGAAVRSCGV
SVSEAEGKQITTIEGLTSEGVLHKVQQAWLDNDVPQCGYCQSGMIMAVAALLKDNPKPTD
QDINDTITNICRCGTFQQVRDAIHAAANA
>A0A7Y9HT63|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MAKLNVNGTVMEYEAEDDTPLLWVIREQLGLTGTKYGCGMAQCGACTVHIDGQAIRSCVY
PASAVTAAQKVTTIEGLSPDGSHPIQKAWAALDVPQCGFCQSGMIMAAAALVRDKPKCTD
ADIDAAMTNICRCGTYNRVRKAIHVAVRGGDPASAGLAIERIEGSKA
>A0A7W9EQF4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis panaciterrulae|TrEMBL
MTKFSVNDRPVEYRMDPETPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAIRSCLV
TIAECEGRLVTTIEGLSRDRSHPVQQAWVAEQVPQCGFCQSGMIMAAAVLLRGNSSPSDA
EIDAAITNICRCGTYPRIRAAVRRAGRVLRGEERIAAAPPPGIRPEDAARAVPAMRAPPG
S
>A0A7Y9HJ82|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MTSLNINGKQVDVQAEADTPLLWVLRDELQMSGTKFGCGMALCGACTVHLDGQPTRACVT
PVSAAADKKITTIEAIGDSAVGKRVQAAWAEIDVPQCGYCQSGQIMAATALLKAIPKPTD
KDIDQAMSGNICRCGTYPRIRAAIHKAAKA
>A0A7W6YY71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MELIVNGVHHNVDADANMPLLWAVRDLLGLHGTKFGCGVGACGACTVHLDGVAVRSCVTS
LADAQGKPVTTIEGLGNGGEHPVQRAWKAANVPQCGYCQPGQMMQAASLLKQTPKPSDEQ
IVEAMSGNVCRCGTYQRIKVAIKAAAEQV
>Q3IXF4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)|TrEMBL
MIHLTVNGREMSLDVDPDTPLLWVLRDELRLTGTKFGCGVAQCGACTVMLDGMPRRSCVT
PVGMIENASVTTIEGMEGPEISAVQAAWAASDVPQCGWCQSGQVMSATALLRQIPKPTDE
EIDHAMGGNLCRCATYVRIRQAIHDAARTLEG
>A0A7Z0CEM1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter geojensis|TrEMBL
MGRIKTIARRSFLVGSAAILGGVAFGTYMYKRDVENPLTAGLAEGEVTFNPFVKIDADGV
TLITPRADVGQGAYSVQAHLIAEELDIDLETVRIDPGPPSAAYYNGVVAVEGMPVAATSE
TLMARTGRGAADVVGKLMGLQITGGSSTVPDMYERLRTAGAMARETLIAAAAEQTGVSAD
QLRTQNGAVVLPDGTQLAYTDLAATAAQTPVVEEVALRDPATWRTLGKPHQRTDIVAKST
GTQEYGIDIRMDGMVHATTRTNPAIGGGITGFNATEAEAMRGVQAVLEISGGIAVVADNT
WRAFQAANAVECDWGPSPYIGDTAKQFEEVAASFIEDRQDSRFKDEGEIEETLDTAEDVL
EAEYRIPYLAHAPLEPMSVVVKLGEGRLDIWTGTQIPRFVQDGAAAVAGLESGQVHVHVL
MSGGSFGRRLEDDYVRQAVEIAMQLPDIPVKMVWTREEDMTHDFPRPLAMSRARGAVADG
AVRAFDLSIAAPSVAESSLARLGQPAMGPDVAIVAGAWDQPFAIPHYRVTGYRVPAMVPV
SSWRSVGASGNGFLHESFMDDLCHAAGVDPMAERLRLCSHDLSRAVLEEVAKMSDWGSDL
GPKRGRGLAFTLAFGVPTAQVVEVSDTPDGIRIDKVFVAAEVGRVLDPVNFEAQLSGGVI
WGLGHAMNCELTYEGGMAQQDNYHAFEGMRLHQTPQIEVRGLENGDEIRGVGEPGVPPAA
PALGNAIFAATGQRIRELPFAKTVDFV
>A0A6I1Z6S0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. RB17|TrEMBL
MDSWGHAPGTAGMGRRRFLGYVLAASTLTVAAELGEAVLAPDEAAAVVPSVPGPAEIYDL
NDMLTDAALPTANLITIRIDSDGTASFALPRAEVGQGITTSSAMLIAEELELPLERIRVT
LADARPELLFNQLTGGSNTTISTFTPIRVAAAVARGRLLRAAALELGEALDTLTAKAGVI
TSSASGRSVTYGELAGKAASVTTSQVAVALKEATHFEVIGTAQRRIDAREAVTGRKTFAM
DLQIPDALPTMVCRPPTINGTVRSVENLTEVRAMPGVTDVVAVSTGVAVRGRTFGQCIDA
VRALKVSWGPGTADAQSDDTVRDELRRAELPLPALDLLTKSVDARFTFHFASNSALETNC
AIADVRDGSAEIWGSLKSPIVAREQIALKLGLPVSAVKVHVTEGGGSFGRKLFHDAAAEA
AEISKAMGKPVKLMWHRTDDFRQGRTHPMATSRVRATYALGQVLAYDQRHTSVATDFGHG
VGEIITAQAARLPVGDLTFSETIFALSQQTPYNFGVVTQVLGETDKGFNTGSMRNIYSPN
VRCAQELVVDELAKRMGKDPYRFRREFLKEERARAVLDKVADVGEWGRSMPAGTAQGIAL
HPEYHAYVAVLAEIDCRPETTGRTVRDAYTGPRVTKVVCAVDVGLAVNPRGLEAQMMGGI
MDGIAITLSSGLHLDNGHFLEGSWDNYFYTRQWNTPPELEIVVMPPTTGQPGGAGELAVA
GAAAAVACAYGRATGSMPTSFPLNHAGPLGFEPLPTTPPIPASPTDGLERTF
>A0A3G7BMP1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MSTFKTIAGWSLAALSLAVTAGVFLSWQPAIAPLDHHDIQYFSHAQIAKGEQLAALGDCA
VCHTAPGGARNAGGLAMRIPFGTLYSTNITPDPETGIGSWSYPAFERAMRHGIDRSGRYL
YPAFPYTAFTKTRDEDLKALYAYLMSQPPVRHQPPQTDLHFPFNIRPGILAWNWLYLRPG
AMADDPGRSAQWNRGAYLSEGLGHCSACHSPRDPLFGERGGRRHLSGGVAEDWSAHALAG
GKAPLAWTEQDLLDFLRHGYSPRHGVAAGPMAPVIHEGLAQLPEADLQAIAHYLSSLQPA
RAAPASADSLNHQAEQRTEPLGSPGARLFSGACMACHAQEKGPTLTGVRPSLALNSNLYA
DRPDNAIRVILEGIAQPANPELGYMPAFRHSLDDQQIVDLLTFLRQNLAGQAPWKEVKQR
VSQIRASLPPG
>B2AIA1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MTRFQVNGQPKDVDVPGEMPLLWALRDELGMTGTKFGCGMALCGACTVHVDGTAIRACVT
PVSAVAGRSVATIEGMESDRVGQAVQQAWIQHNVAQCGYCQAGQIMTAVSLLKTTPAPTD
RQIDEAMSGNICRCGTYPRIRAAIRQAAGRLAQGGQ
>A0A5P9I0A8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. THAF9|TrEMBL
MQLTIDGTDHEIEVEDAMPLLWVLRDVLGKTGVKYGCGIAQCGACTVHIDGEAVRSCQVA
ARDVSGPVTTIHGLGSPETRHAVQQAWIETQVAQCGYCQSGQIMQAAALLSETPDPTDEQ
IDDAMSGNLCRCGTYPRIRAAVKTAAAKLKEA
>A0A383RWY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas reidholzensis|TrEMBL
MQLRINQTTYEVDAEADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREITTIEAIETDEVGKRVVAAWVENQVAQCGYCQSGQVMAATALLKHTPKPSDE
QIAAAMVNLCRCGTYNAIHTAVHALAAQAPKQEGA
>A0A7X6FHV4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MKTLIINGETHQVDAPDDMPLLWVLRDIIGMTGTKYGCGIAQCGACTVHVDDMAVRACQT
TIDMINGQKITTIEGIGKSEIGAKVQAAWLEKEVVQCGYCQSGQIMSATSLLAANPTPTD
AEIDEAMAGNICRCGTYVRIREAIHSVSA
>A0A2X2C5Y2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas luteola|TrEMBL
MLTLNINGADHQVDVPDDMPLLWVLRDVLGMTGTKYGCGIAQCGACTVHLDGTAVRACVL
PVSNIAQGQKIVTIEAVGESDLGKKVQDAWLEHEVVQCGYCQSGQIMSAVALLSQHPNAG
DAEIDAGMSGNICRCCTYTRIRGAIKSVSQA
>A0A385AZN6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Micromonospora sp. B006|TrEMBL
MSPAHLRTARATTSASVPRFLGYVLAAPVLVTAAELAAAYPRAARLPSPDVTGLLGLGHV
LTATALPAAELISVEVGPDGTVSLTLPPGRIGHGGDGSAAELIAEELSLPRRRVRVPPAD
ARPRPAAGGGRAGPGPAVAIRTPVRVAAAVARRRLLEAASATLGAPVAGLRLAAGAVTDG
AGRRLDIGALAVTAATTRTIAVAVDVASR
>B4ED11|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)|TrEMBL
MSRPADAVRAQPVPNAARRVFLKGGVALAGSLLLPLAFGDVVQAAGDGARFREINDWVRV
DADGRTIIGLSQAEVGQGVHTGLPQVLADEMDADWRSVTVEFVTGRDAYRIDAANEAPQQ
FVGASMSATMFYTRLRIAGAQARSAFLRAGAARLGVRDTQCVTRDGRVIHPPSGRSLSYG
ALVDDAARLPHDPQPRLKPASAHTLIGRPLHKLDVPAKVDGSAIFGIDVQVPDMLVGALT
MAPTLNGKPSAVKNRDALRAMPGVADVVVAKDAVIVVAQTYWQAKKACDAADIVWDAGPT
PAFDSTTILAQRKGALQAEHAVVATQVGEPGRHLAESGNVVEADYHTPYIVHATMEPVNA
TVHVRAGEIEVWGPIQGQDKVRWTLSALFGVPAERVIVNTTFLGGSFGRKYVPDFVVHAA
VASKAVGRPVKVIRSREDDIRHGFYRPCASARFRAALGRDGLPVALHARVAGHSLYAAIK
RDRYDKAGGWDETMLDGLYDLCYDVPNLLVDSVTVMQPIPVSFMRSVGSTSTVFFLESFV
NELAHTVRADPVQYRRALLKHDALALRVLDATAARANWFGRAPAGLSRGVAYSLYTGRGG
AFSTYVAAVAEVRVTRGSVRLERIVCGIDCGRAINPLLIREMVEGGVGFALTNTFRSEIT
FEHGAVVQRNFADYPLLGLAAMPKIEVVIVDSDRDPQGCGEVALPPVAPAVADAIWRATG
ERPRSMPFDTPLAT
>B4EQ86|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)|TrEMBL
MVTLNINDRPAEIDADPSTPVLWVLRDNLGLTSTKFGCGTGDCGACTVHVDGRPARSCTL
ALSAVGNARITTSEHLADDAVGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRGNKAPTD
ADIDRAMAGNLCRCATYQRIRAAIHDAARALA
>A0A0S4WHW5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MVTLTINGRLVEVDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAAVGAQITTSEHIADDKIGKVVLAAWIKHDVAQCGYCQSGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAAKALA
>A0A7W5A859|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides albus|TrEMBL
MGTHNSDGPARVSRRSFVGYVIGGATLITAADLGLAPPAANALPVPSVPQVPELYDLNDF
LTHCAMPTSNLIAIEVDEKGHAHFALPRMEVGQGITTAVAMLIADELDLPVDHVHVTLAP
ARPELLFNQLTGGSNTIVSMYTPVRVAAAIARKALLEAAAILLGGAVTQLTSKDGVISLP
DGSSVTYGEAAAKAAKPTTEKVEVELKKTADHQIVGKPHRRVDARDAVTGKKQFAMDLDI
PNALPTMVCRAPELNGTPESINNKIDVETMPGVTHVAIIPTGVAVRAKTFGQCIDAVRAL
DVTWNSGTVTTLSAKDIKAELKAGQIPLAVPKIGATSVDGEFTFHFRSGSALEPNCAVAD
VRDGKATIWGGLKSPIDAQGRIAKALGLPQTSVTVNVVQGGGSFGRKLFSDAAVEAAHAS
KAFGAPVKLMWHRADEPRQGRVHPMAVSRIRATVLAGSVLTFEQRHASVATDFTHGLGER
LTAEAAALPTGLSNLTFSESIFLLSQELPYNFGVITQLLNEPKPAVDRFNTSSVRNIYSP
DVATASELMVDQLAKKLKQDPVTFRRNYLKSKSVKRVLDRAAELGDWGRSMPAGTAQGIA
IHKEYKGATAVLVEIDCRPETVNRKVRDAVTGPRVTKAVVVADVGLVINPAGVKAQMMGG
FSDGMCQALTYSNHLVDGQFLEASWDNSAYTRQWNTPFEFECEVIESHGNQPGGVGEAGV
AASMAAVACAYARATGKMPTEFPINFHDPLHFEPKSFVPSVPESPTDGLAYTF
>A0A6J4FH98|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Magnetospirillum sp. LM-5|TrEMBL
MDRQLPLSRRSFLLTVGAAGAGLTLGFKAQAADPAQPPSSPFQAYLRISPDSTVTILSAH
MDMGQGIYSGIALLVAEELDLDPAAIAVEGAWGNPKLYGNLAWGGVAQGTGGSTAMKSSF
QRYRMAGAAARAMLVEAASQAWRVSPHLVRVEHGMVIGPKGRKASIGAFAEAAAAQPVPA
EPHLKSPTEWRLIGKEGFRRLDSAAKSTGRQTYTADLRLPGMLTAVLARPPLFGATVKSF
DATAAKAIPGVVEVAATSRGVAVIATDTWTAIKGRQALTVEWDQTHAETRGSAQLWAEYR
RLAGESTPAPIAASRGNPDQALKRAVARIDATYEFPYLAHAAMEPLNAVAARTGDMIEVW
GGHQMPDLYRALAAKAAGVAPESVRLHVMMTGGGFGRRAVADGDVVVEAVECAKAIGWRA
PVKVQWTREDDMTGGRYRPMMLHKVAAGIGLDGQPLGWRHRIVGQSIGAGTPFEKMLVHD
GVDHTSVEGVSDSPYAPADFHCDLISPKVGVPVLWWRSVGLTHTAFVTETLIDEMAVLAG
KDPLAYRRALLADHPRHLAVLDLVAAKAGWGDKLPPGRFRGLAVHQSFGSVVAQVAEIAL
DGKGGFKVIRVVCAVDCGLAVQPDQIRAQMEGGIGFGLGAALYGRITLTDGRVDQTSFNG
YEVLRLDEMPVIEVHIVPSAAPPTGVGEPGVPPIAPAIANALAAATGKRTRTLPFKD
>C7C6L2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)|TrEMBL
MISLSINGHQHSIDVEPDTPLLFVLRDTIGLTGTKYGCGIGQCGACTVLIDGQAIRSCQM
PVESVGAQTVTTIEAIEADPVGARVVAAWVGIEVPQCGYCQSGQVMAATGLLKETPKPSE
DAIAAAMTNLCRCGTYNAIAAAVRQAAA
>A0A7W7NW57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium chloroacetimidivorans|TrEMBL
MASRRGVLIGGLAGGALAVGYMLRPRRYALPLTPGKDEVAFDAWIKLAADGVVTVAVPQV
EMGQGVTTLIPQVAAQELGADWRQVAVEPAPISPLYANVPLAAQWAELTMPATPDWLIGE
DGAWVRRWAQDHAFTITADGTALAAYEAQVRNAAASLRALLCMAAASRWGVAWQECGTAK
GFVVHEAKRLPFGPLASLAARFDPPGTPPLRAEPPGENPDDLPAGSPLNFPRLDLPAKVD
GSFVFAGDVRLPGMVYASIRHGPIGASTLAGYDKDAANSVRGLVTLVRNPGWIAAVATNW
WAADTALTRMDARFAATNRADSSAIDAAMDKAMQSGTATRIHSLGDPDSYLSGRLPLQLR
YEVAPALHATVETASATAHFHDGRLELWVGTQAPQAAREAAARALGIDPLAVTLYPMPLG
GSFDRRLENDHAVEAALIARACGRPVQLMWSRKQEHMAARPRPPVVAVLGANVDPAGRIG
GLRARIAAPPAAREFGRRLLHGDAPFAAIAAVAGETDAMVLAGAVPPYAIEHVAIDHVPA
QVPLPSGRMRGNADGYTAFFTESFVDELAHRAGREPLGYRMAMLGNDPRLAECLQRVAAL
SGWGGGGDNSGQGIACHVIGAGRIAVVASARRDADGVRVDKLSAVADIGRIVNVDIARQQ
IEGGLVFGLGLALGCSTAYEDGLPVTGRLASMSLPVLADCPTIEVAFVKSAAEPADPGEL
GVAAVAPAVANALFSATGLRLRQLPLLSEDV
>A0A375EYF4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEARADAGVATLDRRSFLKLTGLAGGGLALGVAPLAQAQEGAK
PKAPPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPSSCKVEQGVIT
SGSQRATFGELAPAAMALPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKSFSADKARAVPGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSKVSSQALFDEYAKLAGQPGTVARAGEGDIAAAIQRAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVMGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLEMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNPLSAE
AQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSQDNPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A4P8HQM6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MKLNINGKQRQIDADGDTPLLWVLRDELHLNGTKFGCGMALCGACTVHVDGQPTRACVMP
ASAAVGKKITTIEAIGANPVGQRVQKAWAAIDVPQCGYCQSGQIMAATALLKANPHPTDK
DIDEAMAGNICRCGTYQRIRLAIHKAARNA
>A0A1R3V708|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium prunaredense|TrEMBL
MARLIINGTPRDIEVDPDTPLLWVIREQIGLTGTKYGCGVAACGACTIHIDGVATRSCVL
PVSAVEPDQQITTIEGLSPDSSHPVQQAWLALDVPQCGYCQAGMIMAAAGLLMQNPNPAD
EDINAEITNICRCGTYNRVRAAIKLAAKAGEATQRG
>A0A846V6A3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. SG609|TrEMBL
MNARFGDPLGEGRPDNPSRREALKLGGLVVAFLWLGGGAKVLGRAVAQGPVAAGDPAFAP
NAFIRVGADGSVHLVMPSIEMGQGAYTGQATLLAEEMDLGLDQIVVEHAPANRKLYANPL
LGEQATGGSTTIRYCWTTMRQAGAAARTLLVNAAAAKWKVDPAQCTVARGVIRHEASGRT
VGYGEVANAAAQLPVPEKVQEKDPSAFALIGKPLRRVDTAGKVDGSLQFGIDLRVPDMKI
ATVKACPTFGGKLVAVDDSRARQVPGFVAVLKIADAVAVVGEHFWAAKQAMEALDITWDH
GPNAHYSTEQLFKDLAEASKNGTPIPGKAVGNVDGVKGKALEATYQLPLLAHATLEPQNA
IVHVRPDGCDIWTGTQVPARCVDVAAKLTGLKPETIVVHNQYMGGGFGRRLFEDPVEQAV
AFARQVSYPLKVVWTREEDIAHDRFRPAYYDRIAATLGDDGKPLAWTHRITSGSVLATFA
PGAMAKNGMDSDAIECAADLPYEFPNVKVEWVRHDPPDGLHLGWWRGVGPVHNVFVIESF
IDELAHAANKDPLAYRRDLLQKNPRALAVLNLAAEKAGWGKGSLPARVGRGVAVAAPFGS
YLCVIVEAEVSPQGEVKLRRAVAAVDCGVAVNPNTVEAQIQGGLIFGWTTALYNGITLKN
GTVQQHNFNDYRMMRINETPALEVHLVDSKETPGGIGETGTVMAFPALFNAVFAATGVRL
RSYPIDRAALVQGAEALKAVVTQASDHGQAQEGKV
>A0A839F2I6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dokdonella fugitiva|TrEMBL
MPDQPAHATETADSADPAKPHPARPREPLQVTINGKPYFHDGDPAMPLLWFLRDTLRLTG
SKFGCGIGNCGACTVLLDGKAMRACVLPMSVAATHQVTTIEGLEGDALHPVQQAWIEEDV
AQCGYCQAGQVMAAVDLLKRKPKPSDDDIASIGNLCRCGTYPRIRKAILRAAELMQGERK
>A0A1L5NLY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium gallicum|TrEMBL
MSYDLSVNGKNYAVDVDGDIPLLWVLRDTIGLTGTKFGCGIAMCGACTVHVDGVPVRSCV
MPVAEAAEKPITTIEAIGETDEGARVQKAWLDIDVVQCGYCQSGQIMSATALLAANPSPT
DDDIDAVMAGNICRCGTYPRIRAAIKLAAKAR
>A0A1L5NSQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium gallicum|TrEMBL
MVQLTINGVARDIDVDPETPLLWVLREQAGLTGTKFGCGIAQCGACTVHVDGVATRSCAM
PVSAIDANQQIVTIEGLSADGSHPVQQAWLALDVPQCGYCQAGMIMAATALLNTTPDPTD
DDINAEITNICRCGTYNRVRAAIKLAAANSSAAQKG
>A0A841HLN4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MSRRTTMDEAPAPAPLRNATLTINGASRNVEVPEDMPLLWVLRDRIQLTGTKYGCGMGLC
GACTVLVDGQPIRSCITPAASLAGRAITTIEGVAGSSSRAGKEVQRAWLAEAVPQCGYCQ
SGQILAATALLEATPKPTDADIDAAMAGHLCRCGTYPRIRRAIKKAAAALSETTRPGSQS
>A0A388RWB4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MITFKLNVNGKPHTVSADGDTPLLYVLRNELGLHGPKFGCGLGQCGACTVLLNGTATRSC
LLPVSTLPGANIVTLEGLGTPERPHPLQSAFIKEQAVQCGYCINGMVMSAAGLLRSNANP
GESEIREALAGNLCRCGTHTRIIKAVRRAAAFPKEEI
>A0A388RHD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MSDSQISVNGKSVEIRADGCTPLLWVLRCELKLTGTKFGCGVGVCGACAVHVNGKLLLSC
QHQVSEMAGKKIVTIEGLDGPEANALRAAWQKHEVVQCGYCQSAQLMAASALLKRTRNPK
ETEIADQMSCVICRCGTYTRIRRAISEAVAMLRG
>Q1LQU5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)|TrEMBL
MRIRGIEALAGGSGAAVKTGDAVAPLTRRGFLKLTGMAGGGLALGIGSVVESAHAQGAAK
PASSPQAFLQIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWKNVRAILAPAGDPY
KDPMFGIQMTGGSTAVNHSFEQYRELGARARAMLIAAAAQQWKVDPASCATSLGVVTSGA
NRATYGELAQAAMAQPVPAQVKLKDPAQFRIVGKPTPRLDAASKLHGDGVFGLDVKLKDM
KVAVVAHPPRFGGKVKSFNADKARKIKGVADVFLVPVDRGGTGVAVVADGYWPAKTAREA
LEIVWEDAGSKVSSAALFDEYSKLAAQPGTVARALEGGNIDTALSGAAKVIEAEYRVPYL
AHAPMEPLNCTMQAEIAANKATAVKVWVGSQFQTIDQAAIARTLGLTPDKVTLNTMMAGG
GFGRRAVPTSDYLVESANVMRSWIAAGHTEPLKVMWSREDDIKGGYYRPLHVHRARVGVD
AQGKVVGWQHTIVGQSIITGTPFEPMMVKNGVDATMVEGIIENDYGLPLQLNVHHPKTDV
PVLWWRSVGNTHTAFVKETLADEMATAAKQDPVAWRMARLDEKAHARHRAALQLAVDKSG
YGKKKLPKGHAWGVAVHESFGSVVAYVVDVSIEKGQPKVHRVTAGVHANRVVNPLTAEAQ
VQGGCVFGISMTKPGFAIEIENGVVKNSNFPDYPPPRITDAPVVDVFFVPSNDNPTGLGE
PGVPAISPAIANALFRLTGKRQRQMPFVLT
>A0A222E880|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Antarctobacter heliothermus|TrEMBL
MASIGKIARRTFLFGAVAVAGGAAFGAWYVTRPAPNPLKPAEGEASLNAFVLIDGDGVTL
VAPRAEMGQGTMTTWAALIAEEMDLAWEDVRVIHGPPAQAYYNSALMGEGLTHKGYDVSS
FQHSLGEVMGVMGKVFSMQVTGGSTAMKDGYERMRVTGAATREMLKTAAAQRLGVGLDEL
RTENGAVIAPDGTTIPYSDLAAEAAEVEPPKVELRERSDWKLLGTSLPRKDIPGKSTGTA
QFGIDTRLPGMRYAAVRMSPTRGGMKSFDAFEASRMAGVEKVVDLGDGLAVIATNTWLAQ
QAVDAIPVEWAPSSYPETTEDMTRAIKAAFDAEPNSTLRDDGDTAKLPSGAMRIKAEYSV
PFLAHATMEPMNATAWFDGTHLRIWCGNQGPTFLRDACAAEAGIDPEEVEVNVTLMGGGF
GRRGEFDYAVIATRVAKAMPGTPVNVTWSREEDMTHDFYRPAALARITGAVLDGKALTFD
AQVSSPSIAEQALDRWVGFAPGGPDKGIVDAIYNQPYGIPNYRVTGHKAEITPPLGFWRS
VGASYNGFFHESFMDELAHAAEADPLQFRLDLTRDEWLPAYYVLEAVRDMSGWTGQTEDG
VGRGIAMVYSFGTPCAMVIEVRDVDGMIRLTNAWIAADPGVALDPSIIEAQLTGAMAYGL
SAAMGEEITFAGGVAEQKNFPDYDPLRMPQMPAVEVRILENQKRLNGVGEVGTPPAAPAL
ANALFDLTGKRVRDLPLNKAFEFYV
>A0A0L6CV10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius tolerans|TrEMBL
MQLSVNGADHSLEDLEPEMPLLWALRDVLGIKGPKYGCGIAQCGACTVHIDGQAVRSCQV
AVGDVWGPVTTIEGLGTPDAPHPVQAAWIDAQVAQCGYCQSGQIMQAASLLSETPDPTDE
DIDDAMSGNLCRCGTYPRIRAAIKAAAKSMSEGA
>A0A378YKW7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea pnomenusa|TrEMBL
MTQQNAEPTVRPAHPQDPACGTAPHANAPTSPARRHWLKGMSLAAGSLLIPVTATWVGSP
SARAAGANLVEVNDWIRIDADGTTVLGLSQCEVGQGVYTGLPQVLADELDADWRRVRVEF
VTARDAYRTAAANEALQQFVGASMSATLFYERLRVAGAQAREALVAVGAKRLGVRTSNCV
TRDGRVIHPQSGRSIGYGELVADAAKQPLNPHPHLKNDAAHRLIGQSLARLDTPSKVDGS
AIFGIDVKVPDMLVGAVRMAPTSGGAPRSVRNRDAIRARKGVHDVVLAKDAVIVVADDYW
RAKTACDALDVEWKAGPAADSATILAERRAALVGGKAGVATDIGDATGVIAAGGKVVTSE
YHTPYIVHATMEPVNATVHVRKDKGEIEVWGPIQGQDKVRWALGGIFKLPPEKVTVHTTF
LGGSFGRKYVPDFVIHAAVASAAVGRPVKVIRSREDDIRHGFYRPCASARFQAALGSDGL
PVALHMRVAGQSLYNVIKKDHFEKAGYDETMLDGLYDLAYAVPNLRVEGVDVPQPNIPVS
FMRSVGSTSSVFFLESFIDEMAEVAGIDPVDYRKRMLRHDPLATRVIETTFASAGWQRKA
KPDVHRGFGYCTYTGRGTAFSTYVAVAVELRVVNDRFKIERVVCGVDCGRAINPNLIRAN
IEGGIGFALTNTFKSRITFANGGVAQSNFGDYPLLYLVEMPKIETVILPSDRPPQGCGEV
SLPPMAPAVAQAIRRATGVRARTMPLPQTVAEARALVHAGTPGATPVPGAA
>A0A1M4E4N0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea gerenzanensis|TrEMBL
MIRLTVNGAAAEVAADPGTPLLDVLRGELGLVGTRFGCGVGLCGACFVLLDGVVTAACDT
PLSAAEGRAVVTVEGLAPGDSLHAVQRAVLEEQAGQCAYCLSGMMVTAAALLARDPRPDE
EAVVAALDRHLCRCGVQRRVVRAVLKAAE
>G2LLQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chloracidobacterium thermophilum (strain B)|TrEMBL
MPTTVTINGTKQTCDAPPEMPLLWVLRDVLGLTGTKYGCGAGLCGACTVHLDGVAVRSCT
LPLSRVEGKRVTTIEGLSPDGTHPVQQAWKLEDVAQCGYCQPGQMMAAAALLAAKPKPTE
EDIASALAGNLCRCGTYQRIRAAVQRAATLQKGEKRS
>A0A5M9IQ88|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas extremaustralis|TrEMBL
MITLKLNGQDHSLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGAVKGQAISTIDNLHTDPIGQVVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
AQIEEAMVGNICRCGTYNRIKTAIRQAATHLQEAKA
>A0A5M9J285|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas extremaustralis|TrEMBL
MLNDIFTTERPRALQHMLERDQAGGSFTLPRRSFLKIVGIGGLALGAFPHLALAQEATGG
DVAPLKPSQQPSAFVQIDSSGEVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
SNNNAYQDPIFGMHLTGGSNSIKNSFTQYRELGARARAMLLSAAAARWNVDVASLTTKAG
MVFGPASRKASYGELAEAAMALPVPEKVTLKDPKDFRIIGQATTRIDAKAKSSGQQDFGI
DMHLPGQLTAVVARPPVFGAKIASMDDSAARAIKGVKAVLRVPLDGGAEGVAVVADGYWQ
AKLARDVLKVEWNSTTVEKVDSEKQLAQYRELVRQPGPRQFDADMTPLASAPHQLEAEFV
FPYLAHAPMEPLNCTVQISEGRAQLWVGTQFPGGDSTAAAKVLNLKPEQIQINVQTAGGG
FGRRGVPSSDFIVLACEVAKAARVVGLTVPIRTLWSREDDIKGGYYRPVYLHQARIGFDD
SGKVLAWDHALIGQSILVGTVFGGQVKNGIDPTATEGMRDPYPLPMRLTVHHPELNVPVL
WWRSVGSTHTAFVMETLIDEIARTTKQDPVDYRMKLFADQSPRHRAALQLAVDKSEYGKR
QLPAGRAWGVAVHESFSSVVAYVVEASVQDGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
ALMGLSMCLPGGAITLKDGVVQQSNFADFSVPRITDMPEFAVHVVPSAEPPTGMGEPGLP
ALAPAFANAIASLTGKPIRELPFKLG
>A0A7W6DTY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sagittula marina|TrEMBL
MASAGKILRRTFLIGTAVVVGGAAFGAWVVAKPAPNPLKPAEGETALNPFVVIDGEGITL
VSPRAEMGQGTETTWAALIAEELDVTLDQVRIIHGPPAKAYYNHALVGEAMAGYDASSIE
RSMGELMGHLGKVFSMQVTGGSTAMKDGFERMRVVGAATREMLVAAAAKRLDVSAAELVT
DKGHVIAPDGTKIAYTALAEDAAEMEPPRVELRQPEEWKILGTKFRRTDIPAKSTGTATF
AIDTRLPGQRFAALRLSPTRAGIKSFDAFEVSRMPGVEKVVDLGDGLAVVANNTWIAQRA
VNEIPVTWEDAAYLPSDAAISEALEAGFELAADSMLRDDGDVSTLPMGTDRIEAEYSVPF
LAHATMEPQSANAWFDGGKLKVWTGSQMPTFALRVAAEEAGLDEADVEFNVTYLGGGFGR
RGEVDFTRYATRIAKEMPGTPVLLTYSREEDMTHDFYRPAAKARFAGAVKDGKAVMLDAQ
VSSAPVIGPALDRAAGFSPGGPDAAITEGTANQPYAIPNYRARGYAVPDLPPVGFWRSVG
NSLNGFFMESFMDEMAVAAGIDPLQFRMDLTRDEFLPAWEVLNTVKQMSGWTGETPDGVG
RGVAMCYSFGTPVAMVIEVADQDGAVKITKAWIAADPGVALNPDNIKAQLVGAMVYGLSA
AISEEITFADGAVQQKNFPDYEPLRITQMPETKVSILEVQDHLGGIGEVATPPAAPALAN
ALYDLRGERYRSLPLKKHVDFKI
>A0A0H3KM68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MSRGLIEAGHAGAAMSRRSFLRFGMSLGAAAGGGLLLGFSLPAAGDDTRRSVIGGDADEP
ARAGVFAPNAFVQIDRSGRVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
EKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGANARVLLVSAAAKQWNVDPAACHAENGEV
RHPPSGRRASYGELADAAAKLPVPTDVALKKPEQFKLIGTPAKRLDSPEKVDGVAQFGLD
VRLPGMRYAVIVNSPVFGGTVASVDDTAAKKIPGVRQIVRVDDAVAVVGDHTWAAKRGAS
ALVVKWNEGANANVSTKDLFADLAQAAANGKGAVARKDGDVDHAFSNAKTRVDAVYEQPL
LAHATMEPVNCTVHVRSDACEVWVGTQVPTRARDTAQRITGLPAERIVVHNHLLGGGFGR
RLETDMIGQAVKIAKQVGAPVKVVWTREEDIQHDMYRPCYHDRISAALDANGKPIAWRHR
IVGSSILARFAPPAFKDGVDPDAVEVAIDLPYDVPNQLIDYVRQEPRHVPTAFWRGVGPT
RSTFVVESFIDELAAQTKTDPVQYRRALLDKTPRARNVLDIATKAAGWGAALPQGQGRGV
SVMHAFGSFFAIVADVAVDDGEVRVTRVVCAVDCGMTVNPNTIEAQVQGGIIFGITGALY
GEVTIENGRVTQRNFTDYRVLRINETPPIDVHIVKSGEAPGGIGEPGTAATAAAVANAIF
AATGKRLRKLPIGNQLKTA
>A0A292ZID1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium fuliginis (strain ATCC 27551)|TrEMBL
MDRRTLLVGGGATVGLLLAWAIWPRSYRASLNTAPGETAFNAFLKIDRSGQVVVIVPQTE
MGQGVTTLLPQILADELGADWRTVGVQSAPIGPLYANILLAREWLANDWSRLAGEAGEWT
IDQYATRRALMLTGAGTSVPMFHQPYREAGAAARVLLCKAAAARWDVAWESCDIQNGIIS
DGGQRRLKLGEVVEDAATFDLPEILPFRQAEVDRLAGQELPRLDTPSKIDGSHNFAADIR
LPDMVFASIRQGPIGDAVLKSVNEGAAKSVTGFLKLVRRDRWVAAVASNWWAANKALDLA
DPVFTLSGRPVDSAGMEAALEQAFSGSGERLYAQGDPQPLFGDATILASEYRVRPGLHLA
LEPMCATARIGEDSAEIWMATQAPGLARAAIARALGLSAEAVTLYPLHAGGGYGRRMDFE
AGVQAALLSREMGRPVQLLWSRLEDVIQDRPSAPAHARMAGKLGRNGAIEGWSAKVAAPC
ALTQTWARIAHGKLPHEAGADASGTSTRLAVAGMELPYAVPNWAVDHFPADVGLPLGFAR
GNAHLHGAFFTESFMDELAHQAQMEAMSFRIQMLGGNPRLAHCLTTVGAMGGWQGGIEGS
GQGLAAHVMNGAFIAVMVEAGMAEGKLQVSRIVAAVDGGDQVNPDIARQQVESGLIHGLA
FAMGASVPYAKGMPTRAMLGRMGLPRLGDVGEVTVELIRSTAPPAGLTDLGAPLVAPAVA
NALFTTAGRRFRTLPLLMEG
>A0A137S864|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter excellens LAMA 842|TrEMBL
MTMNRRDFLKVSTGASGSLILAVSIPGCASVQTGYQPETGEWKPDIWLELTRDDEIIFTL
ARVEMGQGTYTGLTTLVAEELDVEPSRIKVRFAPVAPEYRNPLFGLQLTGGSTSLATSWE
PLRVAGAQARQMLVMAAARVWEVDADQCTTQDGRVVHPNGLDSLRYGQLVKLADREVIRG
KVPLKPRAEWKYIGRKGGKLDARAKATGTAVYGMDVELPGMVYAVMTRSPRYGGKASSFN
RDDVIGMPGVTDAFITERGVALVAQRYWQARKAQQKLQVEWDFSEALDTDTEAVFEGYRK
AASENSGVKERSEGNVDTAADRAKQVVEAEYEQPYLAHATMEPMNATAWYRDGGMDVWAP
TQAPDLGRIAAARHTDLSPGKINIHTTFLGGGFGRRLTQDYIEEAAAVAYQLKVPVKLIW
SREEDTRHGFLRPAMLHRMKASLNDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
ELTGWHHQIVGPQVLDWYVRNAAPAQYPWAPKFLYDTLGRVGLMAEGIATPKDISAIEGA
IEYPYQVQNVSVRHTHTDPGVPITWWRSVGYSHNGFAVETFMDELAHESGEDPLQFRLKM
LDAEPRHREVLERAARLADWGQPAPEGRARGLALFKSFGTYVAQVVEAGIENGEIRVYKV
ICSVDCGQVVNPRIVEDQIEGGILFGLTAALYGEINFDNGEIRQSNFHDYRLMQMHQAPD
VVVDVVDSEAGPTGVGEPGVPPVIPALGNALFALTGKRQRRLPLTA
>A0A017H9C5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limimaricola hongkongensis DSM 17492|TrEMBL
MVKLVINGEERQFDGDQDTPLLWVLRDEMGLTGTKFGCGIAACGACTVHIDGAPSFACVT
PVGVLEGAKITTIEGLSENGDHPVQEAWRDLNVAQCGYCQAGQVMQAAALVDQYDTVTDE
DIDAVMSANLCRCGTYPRIRAAVKQAAAAKSGTKEAEAQ
>A0A017H969|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limimaricola hongkongensis DSM 17492|TrEMBL
MRNSSITNVSRRGLLGGMGAGAFVLAVGLPRPGRAQEEEPEFGRDAMPNGWRDDPKIFIA
IAEDGTVTVTCHRQEMGQGVRTSIAMVVADELGAEWDNVRVTQAPGDEEKYGNQDTDGSR
SLRHHFMPLRRAGAAARTMLEQAAAAQWGVDVAEVKADGHKVSHAGSGKSLGYGELAAAA
MDLEVPARDSLTLKDPSEFRYIGKNSIGLVDNMDITTGNTTYGIDVRREGMLYAVVARPP
VYGGKVASLDDSAALAIDGVEKVVQIDPAEFPTEFAPLGGVAVIAKNTYLAMKGRDALQI
EWEDGPNAEYDSEAYRESLSQAANSDGGKVIRDEGDYDAAAAGAAQTVEAEYYIPHLAQA
PMEPPAAVVEIKDGKAEAWACVQAPQVTRLRLAERLGLSEDAVKVNVTLLGGGFGRKSKP
DFVLEAGILSQAMDGAPVKLTWSREDDIRHGYYHTVSVEKMTAGLDADGKTIAWRHRTAA
PTIGSIFAPDPAQKLPFELGMGLLNMPLAIENIRAENPQAQAHVRIGWYRAVSNIPHAFA
IQSFAAELANAAGRDQKDYLLELIGPARQIDPTNQGDVWNYGENPDVYPVDTGRMAAVVE
AAADGIEWGREMPEGRGLGIAGHYSFVSYVAVAAEVEVVDGEVMVPRVSIAIDCGAHVNP
DRIRSQMEGAVIMGVGQALMTEVNFAEGRAQQGNFDSYLIPRMDRAPKRIDVHLVGDDAA
YDRPLGGVGEPGLPPVVPAITNAVFAATKKRIRRLPIADQLRS
>A0A7Y7HVB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MMNLNINGKTVKVEAEADTPLLWVLRDELHMSGTKFGCGMALCGACTVHIDGQPTRACVM
PLSAAAGKKITTIEAIGATPVGQRVQAAWAEIDVPQCGYCQSGQIMAATALLRAIPKPTD
KDIDEAMSGNICRCGTYPRIRAAIHKAAGQA
>A0A7W6CIC2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MPKLTVNGQSREVKASPDTPLLYVLRGELEVMTPKFGCGLAQCGACSVLVDGEEMRACIT
PIGSLDGKEVTTVDGLPARWSKQKGLAHNPDRLHPVQQAWVDEQVPQCGICQFGMMIKVT
ELLEHNPKPSDADIKAALTTSGPSPHLCRCASYAAILDGAHRAAKLMAGEA
>A0A7W9F0E7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Loktanella ponticola|TrEMBL
MSTTLKINETSYDVDLPENVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
IALGDVWGDVTTIEGLGKPGDMAIIQQAWVDNQVAQCGYCQSGQIMQAADLLSNNPAPTD
QDIDDAMQGNLCRCGTYPRIRAAIHDAADKMKKV
>A0A840AI87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseococcus suduntuyensis|TrEMBL
MIPLNVNARAVTVEAAPDTPLLWVLREHLGLTGTKYGCGVAACGACTVHLDGEAVRACSV
PVGEVAGRPVTTIEGLPGGAENPLVRAWVAVQTPQCGYCQTGQIMQAATLLARSPRPSRE
EILEHMQGNLCRCATYNQVVDAIQHAAREA
>A0A841A374|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodesianum|TrEMBL
MLTLNLNGVVREVDADPDMPLLWVIRDQLDMTGTKYGCGIAQCGACTVHLDGQPVRSCQT
RIGDVGEAKITTIEGVHGKVADAVKAAWRGLDVVQCGYCQSGQIMSAIGLLTDNPKPTDA
DIDGAMDGNVCRCGTYQRIRAAIHEAARSLA
>F7RQH3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella sp. HN-41|TrEMBL
MSTFTAVENLSRRDVLKLFGAVGGGLALGASGLTWSPMALAQDKEARLNLFIAIGEDDKV
YLTCHRSEMGQGIRTGILQVLAEELEADWDKIVPIQGLADKRYGSQNTDGSRSIRENYDR
MRQMGAMARTMLEQAAAARWKVPLSEVHTASHRVLHAKSGRSAKFGELALAASEQPVPAL
ESLTFKEVKDFKQIGASRQIVDMDAMLSGSAIYGYDIKVDGMLYASIMRPPVLGSDVASL
DDTATRKVAGVVDVYRLPTPQGAPAFQALGGVAVIATNTWSALEGRKALKVTWTQAGNSQ
HDSSLYLKELVERVQQSGNVVRQAGDEITNWPEANTLKAVYTVPYLIHSSIEPPVATAHV
TEKSCEIWASTQTPQSTQQNVAAALGMEEEAVKVNVTLLGGGFGRKSKPDFSVEAALLSK
QFKRPIKVSWSREDEIQNGYYHAISAQSYQALFDANNKPTALLARTGFPSISSTFAEGVE
YPSGGELDLGFVDVPFALPNLRYEAVKAQAHSRIGWMRSVCNIQHGFSVGSFVDEMAHRS
QVSCPAMWRSLLGEARRETFTDQQFKYGNYGEDLNRHPVDVSRYFGVIDAVEKAQAKAPK
AGKNQGWGFAVHRSFVSYVAVAMLVEVSEDKQLKVLNAIAAIDAGTIVNPDRVKAQTEGA
IVFGLSLALMGEITYKEGKVQQSNFHDYPLLRLPQTPAIEVVIIESNAAPAGVGEPGVPP
VAPSLTNAIFAATGLRIRDLPVNKLLRV
>A0A7W6DQI0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium fontiphilum|TrEMBL
MAISLTVNGEKRMVDGDPAKPLLWVLREDLDMVGTKFGCGAGLCGACTVHVDGNAVRSCQ
MALGDVQGMAITTIEGVQATDAGKRIAATWVAQDVPQCGYCQAGQIMSATALLAQTPKPS
DADIDAAMMGNLCRCSTYVRIRAAIKAAAESAA
>A0A7Y9IR87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pigmentiphaga litoralis|TrEMBL
MPSFTLNGQPTTLDVPDDMPLLWAIRDVAGLTGTKFGCGISMCGACTVHMDGAAIRSCVT
PVSVAEGKAITTIEVMDQDPVGKKVQAAWRQIDVVQCGYCQSGQIMAATALLKTTPTPSD
ADIDGAMSGNICRCGTYGRIRAAIKIAAAT
>A0A509DSZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassocella blandensis|TrEMBL
MYHLLQHHQQATASSADNTKTEITALSTTRRGFIKTISAGSGVFMLGCGVAPSLSQAAAA
ATPDLSSLVFNAFLKITPDNRVIVSIKHLDKGQGVTTGLTTIVADELGASWQQMDWEFAP
ADAKRYNNLYWGQSQGTGGSTSIANSWDQLRNTGASAREMFIQAATKKWQVEVGNITVKD
GIVSDGKHSATLGELAAEAAKQSVPKEPKLKKTADLQLIGKDIPRKDSPEKVNGSAIYTQ
DIHLPGMLTALVLFPPKLRGKLISVDDKEAKKMPGVVDVVKIPRGVAVVAENFWTAKKAR
DTLQAKWDLSASESRGTDQLKQALTNATKQKNHVITTRGDAATTIAKDDIKGQVIEAEYH
LPYMAHAAMEPMNCVVQVTDNGAEYWFGSQAPTIDQSQTAEILGISPDKVIIHTHYAGGS
FGRRACPDDYVLDALHIAKNIKGRPVKMVWTREDDMQNCRFRPMSAHAIKAKVSTSGELL
AWQHNAAAQPILRGTPFGGMIQGPVDPTVYEGISDLAYDFENFEVRATEFESPISTLWWR
SVGHSSNAFVVETFVDQLARAAKVDPLSFRRKMLSKEPRWLGVLNLAAEKANWGKKLPKG
TAQGIAVHKAMGSWVAQVAEVTVSGKDIRVNHVTCAIDCGIVINPDIVKAQMEGSIGFAL
GAIFGEEITLKEGHVEQKNFDSYTPLRMNQMPEVDVYMVDSTERPSGVGEPGVPPLTPAV
ANAVFAITGKPVTQLPIKLV
>A0A7W7YGA0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prosthecobacter vanneervenii|TrEMBL
MITLNINGKAVQVDVAPSTPLLWVLRDVVGLTGTKYGCGVEICGACTVWIDGSAEKSCDV
AVKEVVGKKITTIEGLSPDGASHPVQKAWVACQVPQCGYCQSGMIMKAAAMLRENKKPTD
AQIDGAMNNLCVCGTYQRIRDAIKLAATL
>A0A2N7QQ33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. AD56|TrEMBL
MIVLSINGQDTQVDVPDDMPLLWVLRDVLGLNGTKFGCGMAQCGACTVHLDGEAVRSCVL
PVTGAVGKKITTIEGLNATDLGKRVQQAWLGIEVAQCGYCQTGQIMSAAALLTQKPTPTD
EDIDAAMSGNLCRCGTYVRIRAAIKQAATGQITLPQTIA
>A0A177GA73|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MMPPSFLARNPQFSDGFLAILRPPVAVGGLLARSPASSAAPQDEDVFVVVSARGGVVGYC
GHVDLGTGIRTALAQIIAEELDIPFADVIMVLGDTDKAPNQGATIASETIQISAVPLRKA
AAQARKIILSLAADVTGLPASGLKLDAGQVVALKPHALENSIPYRQLLQGKNLTALLDEA
VEVKDPEHYTVVGKKVSRVDIPDKVTGRAVYVHDVRVPGMVHGRVIRPPYGGFDHGPFVG
NSLITVDRASIAHIPGVLDVVVIKDFVAVVAEREEQADAAARQLRVDWHTPDLPDMEDIE
AALQANLSTPRVVHDQGDVEVALGQLAHRMDRTYRWPYQMHASIGPSCAVAQWAEDSLTV
WSGTQNPHMLRADIALLMAMPESAITIIRHEAAGCYGRNCADDVCGDAALLARAVSRPVR
VQLTRSQEHVWEPKGAAQLMQVKGGLGQGGVPSVYDFSTRYPSNVSPLLALVLTGVVPAV
IPAVAQMGDRTSIPPYDYDNLRVTVHDMPPIARASWFRGVSAMPNSFAHESYIDELAVAA
GEDPVAYRLKYLKDERAANLLDAVARRAQWEPRTTLPAPDPTLKLLHGRGVAYALYVHGP
FPGKPAAWSAWVADVSVDRQTGQIALTRVVVGQDSGMMINPAGVQHQIHGNVIQSVSRTL
REEVTFDETGVTSRDWGGYPLITFPEVPDIDVLMLEQQDKPPLGVGESASVPSAAAIANA
VYAATGVRFRELPLTPEKVRSALDEKLGVYVADPLPLPQAPASGLLPPSPAMARKTGWKA
LLAAGAVASVVGGFIGSLSPWRAEIAPISRPDPTTWSEKTLEKGRQLAAAGDCAVCHTVP
GGTLNAGGLPLETPFGTIYTTNITPDEETGIGRWSYPAFSRAMREGVGRTGQHLYPAFPY
TAFAKMTEPDMQALYAYLMAQKPVRQTVPQTKLSFPYNIRPALAVWKTLFHDSRPFQPDP
SQSAEWNRGAYLAEGLGHCSACHTPRNMLGAEKWRSAWLGGGEAHGWEAPPLGNLSRSPV
PWTANDMFDYLRTGFSERHGPVAGPMAPVVAEMVQMPEQDVRAIATYVASFDTRQAPEDQ
PQQVVKTAEARAAATAWSGQGARVFGGSCAGCHSGQAPHMFGNRPQLALNTNVVSARPDN
LVRIVLHGIPASTLPGAGSMPAFAASLSDEQISDLVRYIRQTFAASSPPWQGVEATVRRI
RAEQLHASTGSAVTH
>A0A1E1V1W0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. BIWAKO-01|TrEMBL
MAKLSINGKVLDVAVDGDTPLLWVIREQIGLTGTKYGCGVAQCGACTVHIDGVATRSCAL
PVSAVSAEQKIVTIEGLSPDGSHPVQKAWIAHDVPQCGYCQSGMIMAAAALLQANPKPSE
ADIANEMTNICRCGTYTRVKAAILDVAASGTLGRG
>A0A177G6R4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MNPKNQKRQSGFLPTSRRALLGAALSGGGGFLLSAFLPGLPLLKASQAQDTATGVVFRPN
AFIRITPQGAVTLIMRNVEMGQGIYTGISMLLAEELGVTLDQVSVEAAPADAAYVDSVAG
QEETGGSSSMRDSWVPLREAGAAARMMLVAAAAHIWDVPASSCQVRDGRVFHSGSERSLS
YGELAEAAMHQAVPAKVTLKPASDFTLIGTSPRRLDTKAKTNGSAQFGIDAQIPGMKIGR
ITACPVKGGHLTGYNRDAALAVPGVVDVLTLPDAIAVIGEHMWAAIKGMEAAFPQWEYGP
NATTSTDDILARMKKSSEQSGVVAVKNGNAQDALKQAHTRIDAVYELPFLAHAPLEPINT
TLHIRPDGADVWVGTQVPGRAQQEVAEATGLRAESIAVHNHLIGGGFGRRLDSNSIGQAA
RFAKQVSYPVKLIWTREEDMTQDQFRPYYYDRISAGLTQDGAISGWHHRTTGSSVTARWS
PEGMQNGLDPDAVEGAAQTPYAMPDQLVEFVRDEPDAVTTLWWRGVGPTHNVFVVESMID
ELAHQSGQDPLALRKKLAAHQPRALKVLDEVEKQSGWGKELPPGHGMGIALHYSFQTWAA
TVMEVAVEKNGQIRLIQAHSAVDCGPIVFPDGIVAQIQGGLIFGLTMALYNEITLKDGRV
EQTNFHNYRMMRLNEAPDIQVHLVSDPDAEIGGIGEVGTVAAAPALANALFAATGKRLRR
IPFAKQLGGEKA
>A0A7Y7IB43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. SG517|TrEMBL
MPVQSFKVNGQNVDVEAPDDMALLWVLRDKLGITGPKYGCGINVCKACTCHVDGKAVTVC
SVRVSDVRGRQVTTIEGLANGSTLHPVQQAWLNLDVPQCGFCQPGQIMAAVDLLRRTRNP
TDADIDAIENVCRCGTYGRIREAIKAAAAMM
>A0A7X0PCY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MPTTLRINGKAVSVNAEADTPLLWVLRGELHMNGTKFGCGMALCGACTVHLNGEPTRACI
TPLSAVGDGDVTTIEGLAGPQAEALRNAWTTLDVAQCGYCQSGQLMSACALLTKTARPTD
ADIDAAMSGNACRCGTYPRIRAAIHQAAGKG
>A0A7X0U943|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MTTLNVNGRLQAVSSGDDTPILWVLRDELGMTGTKFGCGMAMCGACTVHLDGSPIRSCIT
PTSAAAGLAVTTIEAMHADRVGQVVQKAWEELGVAQCGYCQAGQIMAAVGLLKATPRPSE
QQIDEAMSGNICRCGTYPRIRAAVKLASGRLPGAAQ
>A0A840SLL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amaricoccus macauensis|TrEMBL
MTMQTSRRAFLSGLGLVIGVALAPRGFAADALERGDLAGAPGVPAFNAFVRVATDGTVTV
LSKHIEFGQGPYTGLATLVAEELDADWAQVRAAAAPADDKIYANLLFGIQGTGGSTAIAN
SYEQMRKAGATARAMLVAAAAETWGVPASEITVVKGRIAHAASGKESGFGELADLAATMP
APENPVLKDPADFVLIGTDLPKLDTVAKSTGRAVFTIDVQAEDMLVAMVAHPAHFGATVK
SVDDAAARAVPGVLDVKTLPQGVAVYAENTWAALKGRAALAVDWDLSKAETRSSQQIEAD
YRALFAEAGHEAKKAGDVDAAFAGAGLTVIEREIVFPYLAHAPMEPLDAVLMKNADGSID
CFNGAQFPGQDRAAIAEVCGVDLSQVRINTQFAGGSFGRRAQFGSPYIREAAAVFAASGM
ARPVKHLWTREDDIRGGFYRPTYLHNLKGALDKDGNIVAWRQHIVGQSLMKKGEFDESTV
EGAADLPYGIPNLRVTATATDLPIPVLWWRSVGHTHTGFAVESFVDELLQAGGKDPVEGR
LALLGDKNPRHAGVLTRVAELADWGGPIPDGRQRGVALHKSFNTYVAEIAEVSIEGGKPR
VHKVWVAVDCGQPVNPNVIRAQMEGGVGYGLGAILFDQVSLGDGGKIVQSNFHDYRSLRI
HEMPEVEVAVIPSREAPTGVGEPGVPPIGPAVGNAWRRLTGQPVRRLPLSSAELA
>A0A653TS79|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Maribacter litoralis|TrEMBL
MKISITVNGVIKALEIADENTPLLWVIRDTLNLKGTKFGCGKAACGACTLHVDGEAVRSC
SYPVKFAEGKEVTTIEGLGDRENPHPVQQAWIEEIVPQCGYCQPGFMMATAALLNKVPTP
TDEDIDKNIINVCRCGTYYRMRKAIHKAAELQAGKVMNESKTL
>U2EAR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinisphaera shabanensis E1L3A|TrEMBL
MAEYRAPTRDMLFVLNEVLDDQRIRDLPGYDDYEPETVSAVLDEAARFASDVLSPLNRPG
DSEGVHWSEDGIVAAQGFGAAYGQYVEGGWNGLTGSADHGGMGMPRVLGAAAMEMWNAAN
MSFALCPLLTASAVEALENHGSDELKQTYLDKLVTGEWTGCMDLTEPQAGSDLAQVRSKA
EPDGDAYRLFGQKIYITWGEHDMADNIIHFVLARLPDAPAGVKGISLFLVPKYILDDNGN
PGERNDMRCASVEHKLGIHACPTCTMTYGEDGQGALGYLVGEENKGLAHMFTMMNAARHA
MGVQGLGIADRAYQRALAYARDRQQGGRAIVEHGDVKRMLLSMRAQTDVLRAMCLDSASA
LDIAERSDNEDERAAAQARADVMIPVVKAWGTELGVDIANTGIQVHGGMGFVEETGAAQY
LRDARIAPIYEGTNGIQAIDLVGRKLIRDEGRGMRALIADIRATADGSAEGANEHPALSD
ALDLLETATNTLLEAGRDAAMANAFNYLMLCGTVFGGWYAARIADVAKKALDSGTDEPDF
YEARQACARFYVRQILPKARGYAAMVEGGPDVIDCVDAERHL
>A0A2S2DUH9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aquirufa nivalisilvae|TrEMBL
MSTNTTKQTSRRDFIKISAQTAAFLAIGFENLANGKGVKVKNMTHEPHIGVEINPYVLIN
ESGKVTLFNARPDMGQGTSQSIPMLIAEELEVRLDQVEIVTSDGSAKFGSQLSGGSSSVS
TRYLPMRTVGAAVKEMLIQAAANQWHVPISACYAKEGRVYQKNKNISLGYGELVAAAAKL
PVPANPVLKNPADFTQIGKSIPRPEIPSKVNGTAKFGMDVVIPGMLYASIAHAPSIHAKV
KSYHGEKAIASPGVKFVLKTERKMPHASTEAVAVLADSYWAALKGKRLLDIEWESTAADE
MSTEKYFNQLKEAGKSPGFEYKESLTGDVNKAFASANKVIEASYQTPFLAHAPMEPENAT
VYVQDGKVEVWAPVQGPDSLVTELATYLGFKKENVKINVTFLGGAFGRKAYYDYVLEAAH
LSKQINAPVKVVWTREDDTQQGPFRPGMLSVMRGALDAQGKVQAFEHRLNGASILNQVFQ
VPLGNAPDPWAEEGINLPDSPYTFPNRRNSFSLVTTKIPILWWRSVYASTNLFGQESFID
ELAHQAKKDPLAFRLELLAGSPRFVGVLKKLAELSNYQQLKAQGKAVGIAIARSFSSICA
HAIVVEKQGNGVVIKKVYSVIDCGVAINPRNIKAQVQSNITMGLTASIKNEITVVNGQTQ
QSNFHDYAVLRQGEIPEIEVFVMPSAEAPGGVGEPGLPPVAPALCNAVFLATGKRVRTLP
FDISNV
>A0A220W6X5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus sp. SMR4y|TrEMBL
MTAEPDIAQPEKTANGLNRRKFLIGGGALGGLLVAWAVWPRRYEPNVAATENEQVFGAFL
KIAEDGQVTVVVPQSEMGQGVYTILPQILADELGADWRTVAVEPAPINPLYSNIPLAEQW
AETLLPTGSEKLAENAVVRWVAQNVAIREQFMITADSTSIPAFAASFREAGAAARVLLTK
AAATRWDVAWEACAVENGIISNGEKNLRFGELVRDAASQSLPDPVPLRTAGAGSLIGQDV
PRLDLPSKLDGSANFAGDVRIPDMVYAAIRQGPIGETRLKSFNRAGAGKITGFIDVVKGD
KWIATVATNWWAANRALDKISPIFETRGFMAESDRIDALLNEALEDGPGTRFLSRGETKG
AFTGENLFRARYHANAALHAPIETRTATAEYKDGGLELWMATQAPVAAVQAAARALDIRQ
DRVTLYPMLSGGSFDRNLDNEIAAQVALIAKQMGRPVQLVWSRAEDIMHDHCRAPSQARF
DAAMAKSGRVEAMQIKIAAPPSAREQAKRLFDGMDGIEAMRASIGETDSKAIAGLDIPYD
IPNLTVDHHSAFVGVPTGNWRSNAHSSNVFYLESFIDELAGKAGVEPLSFRMQMMNNAPR
LARCLTSVAAMAGWDGGLDRSGQGIACHSMRGGHIAVIASASRGGSGLEVRRISASVDIG
RIIHPDIARQQIEGGIIFGLAMALGSATRFEKGLPTAKRLSDLSLPRLAEIPPIQIEFVR
SEEEPAGYEELGVPAVAPAVANALYSATGVRLRQLPLFGEVS
>A0A6A7SIN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|wastewater metagenome|TrEMBL
MNTPVDDLLLANVSRRHFLKGLAAGSALVLAARWDLALGEEEKEYGADAMPHGWVDDPNV
FIRIDADGTVTVTNHRAEMGQGIRTSLVMVAADELGADWDRVRVEQAPADQEKYGNQNTD
GSRSMRHWFAPIRRAGAAARMMLERAAAERWGVPASECHARVHAVVHAASGRELGFGDLA
AAARELSVPPRERLELKPQSEWRYIGEDAGPAYDVKRGSVVRPKAIDGEDIVTGQAVYGA
DVVFEDMLYAVVARPPVYGAMLRSVDDGEALKVPGVLRTVEIDGTGQPAGFKPLGGVAVV
AENTWAAIQGRKALKIDWNLESAGDNAAYDSEAYRKQLQQTARAPGKVIRDEGDIESALA
DAAERVSATYYMPHMAQAPMEPPVAVARIVNGRAEVWAPVQNPGATRSGVAKRLGLEPED
VTVNVTLLGGGFGRKSKPDFAQEAASLTKAFDGRPVRVQWTRDDDLHHTYFHAVSVDRLE
AGLDADGRALGWRHRTLSPSIGSLFAPDPEHIAPFELGQGFNTMPFDIPAIRLENPEAPA
HVRIGWFRSVYNLPHAFAIQSFAAELAEAAGRDHRDYLLELLGPSREIDPRTFGDPWNYG
ENPERYPIDIGRMRAVIEKATAEAGWGRDLPKGRGLGLAVHNSFVSYTAVVFDVELGDGG
GLIIHSADIAFDCGPQVNPERIRAQLEGACVMGIGIAMQSEITFSEGRVQQDNFHQYLVP
RIDRAPRETRVHLINPDSEAAIGGVGEPGLPPVAPALCNAIHAATGRRIRRLPVGDQLSA
>A0A220W8C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus sp. SMR4y|TrEMBL
MIKLNVNGLTREVDADPATPILWVVRESLKLPGTKFGCGIAQCGACTVHLDGKPVRSCST
PVSAAEGKSITTIEGIAGAVGTLHKVQQTWIEAQVPQCGYCQSGQIMAATALLEKHPRPT
DAQIDAAMAGNICRCGMYGRIRKAIKAAANSEQPAKVEA
>A0A3B0UCC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MVTLRINGEKHIIDVALDMPLLWAIRDIIGLTGTKYGCGKGLCGSCKVLLDNSPVQSCVI
PVSAAVGKNILTIEGTSENLQLLQESWVELNVPQCGFCQPGQLIAATALLDRNENPTDKD
IEEAMIGNICRCGTYQRIKKAIHKTVELKNQHS
>A0A3B0RVJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MTLETSRRHFLKGSAAVALIVGFGAGGLLEARANSAAEKSFNPFIKIRSDNKIIAVVKHF
EMGQGTSTGLTTLLAEELDADWDDMIVEFAPADRKNYANLFWGGSQGTGGSSSIANSFMQ
YRKAGAAARDMLVRAAASEWHVPASEIKTSKGTLSHASGKTARYGDMVAAAAKLKPAEDV
ALKKSRDFTLIGKASLPRKDSASKTDGSAIFAMDVKLPDMLYVVVARPPRFGGKVKSYTD
KATRAVRGVVDVRQIPRGIAVYAKNTWAAIKGREALNVAWDFTEAENRSTAEMAAHYTDL
LTKPGNIAKETGDVDKAWDSAAKKISLNFNFPFLAHAPMEPQNCVIRYEPGKGAEIWDGC
QSPSMTQDVISKILGLAVDAVKVNTTYAGGSFGRRANFTADYGGEAAMAALAIEGRHPVK
LIWTREDDLKGGYYRPMHLEKVEVALDDNNAPSLWRHRITGIPFYPLPTDKLDRSAVEGV
SNLPYAIPNIKVDQHNVKSPISTLWWRSVGHTHTAFSKEVTIDILAEMAGADPVEFRLNL
LRDHPRQAGVLKLAAEKAGWGTPLPKGWGRGVAVHESFNSFVAQVVEVSRNKAGAIKVER
VVCAVDCGIAVNPDVITAQMEGGIGYGLGAVMRNRITFDQGEVVQDNFPDYEPLRMSDMP
KVEVHIMPSMEKPTGVGEPGLPPCAPALGNAIFQVTGERITVLPFGENGIKFA
>A0A3B0RQ43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MLSINGSVIQLPDGMKDISLLDFIREHLSLTGTKLGCNIGQCGACTVHVDGEAMRSCQIT
VDSLDGKKITTIEGLADTWRNGKEGLHPVQSAWIENTVPQCGYCQAGQIMSAAALLEANQ
KPAPEEIDAAMDGNICRCGTYNRIREAIDLASKTLGGNK
>A0A3B0UC99|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MNSSNKVAFSRRSFLKTSALASGGMLIGFNLFTACKPETEPPLDISQLNFNDFNAFIKIA
NNGMVTIFAPNPEIGQGVKTSMPMLIAEELDVAWKNVYVSQGVLDNEHYKRQVAGGSQSI
RQGWKPLRQTGATTRMMLVMAAANRWGVKPEECTTKEGVITNAKGETLTYGDVVLDAAKL
EVPENVTLKDPKDFTIIGANIGNVDIDGIITGKPLFGLDYKKQGMLYASVLRHPAFGQEL
VDFDDSATKAVNGVSQVIRFGNKIAVLANNTWAAMKGKNALKANWKQATKGESTNDHDKL
LKDLLDGSDFKTLRADGDVKKAFAEADKVLEHTYESPFLPHNCLEPMNFYANVTDSKIEL
AGPVQTPASTATRVAKLLERDESEISLEMTRMGGGFGRRLNGNFALEAAEISSLAKLPIK
VVFSREDDMTNGIYRPSIKYRIAASIKDGKITGYHLKEASINGNMYKNIPNFFPAGAIKN
YQVDVANYKSNITTGAWRAPYTNFLAFAEQSFFDELAEELEMDRVQLRLDLLQKVKGTTD
KHIRYSPERMEEVINMVVDKSSWGKTKNGVYQGFSAYYCHNTHVAEVADIIMEKGLPVVK
KVTCAIDCGIVVNPLGAINQIKGGVIDGVGHAMYGNFTFKDGKPQADNFLDYHLIKLNET
PYVEVHFVENDIAPTGLGEPSLPPAGAAVANAIFAATGKRLRKQPFVKNMDPEQLIKS
>A0A5Q4ZIY4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia dioscoreae|TrEMBL
MSVKDEEINEGRRRFLLSGALVVSFSMVPGVGAMAQEVIADEGAAVHVGKETQALAGSLK
TNPYLDSWIRIDRAGKVTVYTGKVELGTGVRTALLQIAAEELDMAPSLITFLTADTGASP
DEGLTAGSHTIADSGSALLNASAQVRGLLVDAAAQHFGVAGSVLSARNAVIKAPDGRSMT
YGEAVGLVDLHRMALPVSPLKNPATFAVIGTSLPRVDIPRKVTGGVSYVQDLTMPGMLHA
RVVMPPVYEARLLQTNTPVILKMPGVVKVVRNGSMLAVVAKGEWQAVQAQRALAAGSQWT
PGRELPDPATVHRDLKAIATQHIEIANTHAAAGAAVKTLGAKYTKRYMLHGSIGPSCAVA
LFKDGAMTVWTHSQGVYPLRDGLAEMLSMPKDKVRCIHVEGSGCYGHNGADDVAAHAALI
AREMDGQPVRVQWMREQEQTWDHYTPAMVTEVSASLDASGSIVDWNYALWSSSHNERIVN
AGRLIPAQWLEKPFVPALSVPMVQPEGGGDRNAIPLYALPNLHVVNNFSPTMPLHTSAMR
SLGAHMNVFTIEMFMDELAAAAGIDPVAFRLKHMQDPRARDVIQLAAAKFGWPRAPRKRN
HGVGFAFAKYKNLMAYVAIAVEVSVVPETGQVILEHAEAAVDSGQIVNPDGIRNQIEGGV
IQSASWTLYEQLQFDTKRIRSFDWSSYPILRFSAVPRSVNVHLIDQPGAPFLGAAEASMG
PTAGALGNALFDATGKRLRDLPLAGEGLRKLIDV
>A0A7X0B1L1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospirillum iridis|TrEMBL
MADTAPDTAMGAALSLSRRAFLLSVSATAGGMALGIMPPAASGADGAGAEFSAWVVIGRD
DTVIIRVPTPEIGNGAMTQVAMNVTEELACAWSRVRVEFGAIHRDYLEKGVYSAGFLPFF
AGHGTDRQRMKRALQLGASARERLKVAAATRWKAAAADIDAQDGVLTHKPTGRRLRYGQV
AAEAARVELAVEPTLKPESDWTFLGKASPAKLNTPDIVTGRLVFGIDVRQPGMVHAALRQ
PPVHGGKVKSVDADAVRGMPGVRAVVIIDPANTKGAPIRPKATFTLGDTTAQWGVAVIAD
HYWQAKMALDALPVDWDANPAAAAFATVEHIRAAVDARLDKAEGRVLRKAGDVAATSGAR
VVDGVYATPYCENAAMEPLNATALVTADGAEVWCPTQDQQQAYWVVIDETGLPPESVKLH
QTFVGGGFGRRTQADDVRMAVAVAKAYPGVPVKTIWSREECFRQGRYRTPITSRFRAVLD
DGTGLPAAVEAEACFTGSRPTFHLTMGFDDVPYFTSGIVPNVLIRSSAQPVHVLNGAWRG
PCYNSHAFIVETFIDECAHAAGADPLDYRLRLVNTWDQSWSDCLRTAARHAGWGRQLPRG
EGLGIAISGWPQAAVHAMGTIVCTVAHVAVSPAGEIRVKKIDVAFDCGRVANRDAVAAQL
EGGTLFGLNAALQEELTLVDGAVVEANFDQYPMLRLADTPPIDIHFDALSGHSRMDIVGE
APVGPVSAAVGNAIFSAIGKRVRGTPFSRHDLRWI
>A0A7S4H3J5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia sp. Tan611|TrEMBL
MELDINNKIYQTDADADTPLLWVIRDDLAMTGTKYGCGLAQCGACAVMVDGQAVRSCVTP
LETVAGKKITTIEAIESDDVGKRVVAAWVRHQVPQCGYCQSGQVMAATALLKHNAHPSDE
EIAAAMVNLCRCGTYNAISAAIHEVAGEGDNA
>A0A166C3T0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. WM33|TrEMBL
MYPKIPLTVNGQKQEIEADPEMPLLWALRDIMDIKGPKFGCGIAACGACTVLIDGEAVRS
CSQPVGEVEGEITTIEGISQGDELHAVQQAWMKHSVPQCGYCQSGQIMAAVALLEENPDP
TDEDISDAMTNLCRCGTYPKIKAAIKDAAQTLGA
>A0A1Y5U3B0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseisalinus antarcticus|TrEMBL
MGRARTIARRSFLIGSAAILGGVAFGAYFVTRPTPNPLLDGLAEGEAALTPFVKITPDGI
TLIVPRADVGQGIASTQAMLIADELDIDPATATLDPGQPHQAYFNATIAAESLPFPGWDH
GFVASTVRDLMGHVARLTSSQFTGGSSSTADLHETLRLAGATARETLKAAAAARTGVPVA
DLRTENGHVVLPDGTRIPYTDLAAEAAAIEPITEVTLRPASQWTRLGKPHQRLDIVAKST
GTQDYGIDVVLLGMLHATVRTNPGRGGDIASYSADAALAMQGVRSVVEVNEGLAVIADNT
WFAFKAAEALEVDWLAPDYPASSDEMWQALTDARSEEYRNSRLRDDGDVEAALNGATVIE
AEYRSPFLAHAALEPLCATVLVEADGVQIWTATQVPAVVRDAAVEITGLDPAQVTLHVLP
AGGSFGRRLDHDYVVQAIQIAATMRGTPIKTTWSREEDMTHDYPRPLHMAVGRGTVANGR
VLAYDLDTISPSLVSSWFGRIFIVPPGPDTMLVWGAFDQPYAIPNYRVTGYAAPPMMPIG
SWRSPGACSNSFFHESFLSELIHAAGADPLEERLRLIADADSRRVLEAVGEMSNWAGADI
GPGRGRGIAFAHTHGVPVAEVIDVTMTERGIRIDEVWIAADCGTVLDPVNAKVQLTGAAI
FGLGHAMNCELTYENHAVQQTNFHAFEGMRLHQTPLFHTQLLGLAERVRGLGEPATAPAA
PALADAIFAATGRRPREMPFSKSVDFV
>A0A238JUP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas varians|TrEMBL
MAKSITVNGTAHQVDLPDDVPLLWVLRDALNMTGTKFGCGVAACGACTVHINGEAVRSCQ
MPLSDVDGDITTIEGLGTPDMMHKLQQAWVDHQVAQCGYCQSGQIMQAAALLETTPTPTD
EDIDEAMAGNLCRCGTYPRIRAAIKDAAGLES
>A0A7W5ARU0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes campanulatus|TrEMBL
MTTSRRRFLGYVLAAPVLVAAASPGEAQAAELLDLNDIMTAAALPTSGLISVEINADGTV
SFALPRAEVGQGITTSTAMLIAEELAVPLHRVKITLADARPELLFNQMTGGSNTTIATYT
PIRVAAAVARQRLLAAAATEFGSSDLRLADGVISTRDGRRIGIGELATKAASPRTLAVPV
ELTAKDDFTVIGRPHGRIDARDAVTGRKKFAMDVTVPGAKPAMVCRPPTINGKPGTVANL
DEVRAMPGVTDVVTISTGVAVRADTFGQCIDAVRALRVTWRPGTVEGKSDTTVLRELASA
ELPLGPRPITPYVEGRFTFHFRSNSALEPNCAIADVRGGRAEIWSALKSPIVARQTIAAR
LGLPVSAVTVHVTEGGGSFGRKLFFDAALEAAELSQKLGKAVKLMWHRADDSRQGRTHPM
ATSRVRIAYAGNLVLGFEQRHTSVTTDLGHGLGELFTAMAAKLPIGDKAFAQTFFQFSHT
SPYDFGLHSRLLSETGKGFNTGSMRNVYSPDTTCARELVVDQVAARMSRDPYRFRHDLLR
GDRSRAVLRAAAEAGGWGRALPAGVAQGIAFHSEYKGVSACLVEIDCRPETVNRPIRDGV
AGPRVTRAVFAVDVGLAVNPLGLEAQMMGCVMDGIALALTSSLHLRDGYFLEASWDNYFY
TRQWNTPPDLRIIIMPSDSDQPGGAGELGVSAAMAAVACAYGRATGTMPTTFPINHGTLS
FVPKPTVPPIPASPVDGLDHVR
>A0A679JH71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax paradoxus|TrEMBL
MIDLLINGQSVAIDAPDDMPLLWALRDIVGLTGTKFGCGIAQCGACTVHLDGQPVRSCVL
PIGSIGKRAVTTIEAISKTPAGQRVQKAWLEVDVVQCGYCQSGQVMSAAALIQRTPNPSD
ADIDMAMSGNVCRCCTYSRIRAAIKQAATGKPEVLQSVVAMPARSAS
>A0A7U3ZJ44|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MAAISLNVNGKKYSLDVDPQMPLLWAIRDFVGLKGTKFGCGIAQCGACTVHLEGKPTRSC
VLPVQAVIGKKITTIEGLGTEANLHPVQQAWIEEQVPQCGYCQSGQIMAASALLKEKANP
TDADIDSAMRGHICRCGTYDRIRKAIKRAAKDSVKADVTGGK
>A0A7U4E4R9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MSTNQSRRDFFKTSATAAGGLVLGFGWFSTEAFEPGVLTKTTADTVDFNAYLAIAPSGII
TIYSPNPEIGQGIKTAFPIIVAEELDADWSKVKVEQSPLDTKKFERQLTGGSGAIRHSWE
RLRKAGATARAMLMEAAAKKWSVPVSECSTSKGFVVHSSGKKLSYGELATDAAQIAPPKE
VKLKNKNEFTLIGTSVKGVDSKAILTGKNLYGIDYKREGMLNAMIQRPPAFGLKLKSFDA
SEAKKMPGIVNVVSFGNKVAIVGKTTWEVMQARKAVKIEWEKEKDLESSSDHDRIFKEML
NSTTATVHRKDGDIEAAFKNAYKIIEAEYQCPFLPHSPMEPMNFFAHFKGDSIEMAGPSQ
TPQAAQGQVAKMFNLAPEKVTIELTRMGGGFGRRLNTDYAVEAAELSSIIKAPVKVTWSR
EDDTTGGIYRPAVRYRFKASIDKAGNITGYMLHGAGMNAGNATRPDNFPVGAIENTLIQS
NDHKSPITTGPWRAPITNFLAYAEQAFLDEVAMAGGKDPIQLRLELLEKAQKNPVGKLTY
EPERFREVTKLAAEKAGWGKKKKGVYQGFSVYFSHASYVAQIAEMAVVKGKPVLKKVYAA
VDCGIVINESSAQNQVFGAIVDGLGHSMYGNLTFKDGAPQQDNFNKYRLIRYNEVPDIEV
HFVKNGIDPTGLGEPALPPTGGAIANAMFKATGKRLYNQPFSEQGATLG
>A0A1E3H5U1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MNATARIAGGRVEIWAPTQGPTGHQQVAAALAGVDPADVDVHTLLLGGGFGRKAEMDFVE
DAVRLAGESGGRPVKVIWSREDDVRHGKYRPLEAQSIRIGLDSAGRIVGWRHRVVADSIF
ARTLPEMFAADGGKDDVITEGSDLRYAVPAHLVEYLRQDDGQPVGFWRGVGAGYVKFAVE
CALDEVAAARGLDPVALRLDLLAAEPRAREVVRRVAEMAEWDRPREGRALGIAYSDTFGS
HCAEVAEVSLDRESGEIRVHRVWCAVDPGIAIQPRNIEAQVVGAVIGGISHALYERITVV
NGEVQERNFDTYRVLRMSEAPPVEVAVIETPGSRPGGIGEVGLPPIAPAIANAVARLTGG
VRLRHLPFLPERVVAALQV
>A0A2X2PN15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cepacia|TrEMBL
MTIELDNTGSVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATAPAADFAPNAFLR
ITPDGAVTVIAKHVEMGQGAYTGIATIVAEELDADWSTVRVESAPADAKRYANLAFGTMQ
GTGGSSAMANSWQQLREAGGKARAMLVSAAAARWKVPAGELTTANGVVTHAKSGKKAAYG
TLVADASKLPVPDKVVLKQPADFKLIGHRIPRVDASPKSNGTAHFTLDTTFPGMRVALLQ
RPPRFGATVKSFDATAARAVPGVVSVVQVPGGVAVVGTGFWAAKQGRDALKVEWDEAHAE
KRGSDEIMREYRQLADKPGTSARKDGDADAAIAGAARKIGATYEFPYLAHAPMEPLDAVV
KLTADSCEIWAGDQFQTVDQANAARTAGLKPEQVRIHTLYAGGSFGRRANAWSDYVVEAV
SIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTEDGKLVGWRHRIVGQSILA
GTPFEAFMVKNGIDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYAVE
AFIDEAAHTAGKDPYAFRRDLLAKEPRMRAVLDLAAQKAGWDPAKPLPKGRGRGIAVAEA
FKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIVAAQMEGGIGFGLGAVMHSAIT
LKDGQVEQRNFDGYHVLRIAEMPKVEVHIVPSAEAPTGVGEPGVAPVGPAVANAIFAATG
KRHYVLPFDSADSAKA
>A0A7W5J7X7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoxanthomonas sp. OG2|TrEMBL
MKLHVNGSEHEVAAPPDMPLLWVLRDLMKLTGTKFGCGIAQCGACTVHIDGVPLRACVTP
VSAVAGKKITTIEGLSSDGRHPVQQAWAELDVVQCGYCQSGQIMTAAALLAVVPSPTDQD
IDQALAGNLCRCGTYPRIRAAVHRAAQLGKA
>A0A5E7IVF0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHSLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQNVTTIDNLHADPVGQVVQRAWLDSAVAQCGFCQGGQIMSATALLKTNPDPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E6U5N3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVIGQNVTTIDNLHADPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E6UEV3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MTVIDDTQVNQPRRIFLKQTATVASGLAIAFYLPSGLAATDNNVPAAAGEFEPNAWVRIL
PDGTVKLVVHKHDSGTGTHTALAACVAEELDVNPMTVQVISPENPFFETYIHPVWKVFST
GGSTSVSLEYDRLRLAGATARAVLITAAAKQWKVSPDSCTTEDGRVLHSASRRCLGYGEL
VGVAAQLPAPAKVTLKDPAQFKYIGKLRHKRDAAAKVCGRFKYSIDVVLPQMLVAVIQRT
PVVGAKVLAVDSSAALQVPGVRKVIAIPGRPDVLGGNQEGVAVLADTYWAAQQGRELLKV
QWSDSPLAGFDSDQLATAQAAAIDDKTAQRVSAMAAGDVAAQWPTAAKLLEADYRMPYKV
QNPLEPVCITAQVADGGITYWGGVQVPSSALEAAVTVCKIKKDKVTINEMVSGGSFGARE
AKYWLFEVAYLAQQAKVPVKLMNSREDEMRSLFMHPATLHRAKGALDAEGRLTALQLNAV
SPASPEQWEPGYFERPDHMDYSTTEAITAWDFAYRPANLDLVWVKHESHVPSGWYRSVSF
IPNVFAVESFMDELAHSGGQDPLAFRLANMHDRPRHVAVLKSAAERAGWGQPLPQGTALG
IATTQGYTSFIAVVARLSKQDGVIKVDKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHAL
FDRMDIKQGRVVQSNFHDYRVARMSDMPAVDILLVEGEPNKPGGVGELGSPPVAPAIANA
LFSLTGVRQRSTPLALG
>A0A5E7DP46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYSGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGSVVGQNVSTIDNLHSDPVGQVVQQAWLDTSVAQCGFCQGGQIMSATALLKVNRNPGD
QQIEEAMVGNICRCGTYNRIKTAIRRAATHLQEAKA
>A0A0M7AKB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii|TrEMBL
MSVTLKINGETRTLDADPESPLLWALRDELGMTGTKFGCGIASCGACTVHWDGMPIRSCQ
TMVGDLEGAEITTIEGVNGKAAKAVQEAWNELDVPQCGYCQSGQIMAATALLTDTPKPTD
EDIDAAMDGNVCRCATYARIRKAIHAAADKMEA
>A0A5E6Q3L8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MTKPVVYPADLLALDQPVNLSRRRFLAGSAIGALVLGFGLPLGASRVQAAAAATPALGTQ
VPAFLEIRPDNSIRLLSPFMEGGQGTFTAMAQIVGEELDADPATFLVEAAPPGEAYVVLE
NGMRITGGSMSVRLSYPVMRRLGALGRAMLVQAASTKLGVPVSELSTEPGRVIHASSGRS
LSYGELAGAAMDLPVPDPDSITLRDPSQFRWIGKPVKRVDAYDKSTGKAVYAIDLKVDGM
LHAAVQHAPRLGMTVAGVRNEAQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAAEALQVQ
WQEPTADSKVRPMPADFSSDGFREHLAAQTGPQREEELEGDFSKALDGAKTKVEATYHNQ
FVNHAQLEPPSALARYNDDGSLEVWLPNQAPDMFRADIAKRTGLDLAQITLHSPLLGGFF
GRHFLYDSANPYPQAIALAKAVGRPIKLIWSREEEFVRDVLRPMAVVKFRAGLDANGMPV
AIEAVSATEGPTEAIAGSPAEKGDPTALEGLSGKSYAIANRRVAQIYVKGPAMLGYWRSV
GNSMNDFFYEAFLDELADKGGQDPYALRMHLLQGNQRLSTLLKAVADLSGGWKRGPFTAE
DGSKRARGVAMASPFGSHAAVIAEVSTENGQVKVHDIWQAIDPGSIVNPAIVEAQVNGAV
SLGLSQALLEEAVYVDGKPRARNYDLYPILPAARMARVHVRIVESGEKMGGIGEPPLPAV
APAVANAVAQLTGQRIRSMPLSRYTFS
>A0A5E7LK85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSIKPVSRRGFLKGSALLGGGLVVAFVIPGAHRFAGGAENQGKVFAPNAFVRIGNDDSI
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAADYGLAGFGGMQITGGSTS
TWMEFDRYRQAGATARLMLIEAAAKRFNVAPSGIRTESGVVIAGDRRATYGELADDAGKL
PMPDPASIKLKEAKDWKLIGKPTKRLDTPEKITGQAKFGMDVQFEGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHKVLQVPTGVAVIADHYWAAKLGRDALSVDWDPGPNSGLDSQAL
LENFRKLATTPGVSVSKAGDTDGTLGKAVKTLDVEYSVPYLAHAPMEPLNCTVRITQNKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
APVKTVWSREDDIRGGYYRSAFLHHARIGLDAAGQPIAWKHVLVGQSIMAGTSLEAAMVK
DGVDKTSVEGVADSPYLAGLTHHQVDLHSPKTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVDYRRTLLKDHPRHLGVLNLAVEKAGWKAPLPDGHALGVAVHESFGSYIAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKDGQVEQSNY
HDYQVLRLNEMPLVEVHIVPSSEKPGGIGEAGVPPVAPAVANAVFALTGQRLRELPLQLS
GV
>A0A0B7D9F1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITFTVNGERRELDEASPSMPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPLAAVAGHSITTIEGLSPTQNHPLQLAWVAEDVPQCGYCQSGQIMSAAALLSTGAAVTD
DSIRNAMSGNICRCGTYGRINKAIKRAANTPKEA
>A4YZ39|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MTIIANPDIASSNSRRGFERHLKVENVSRRAILQTLGLAGGFVLAAPLLSRPAFAAYETG
AGKMPHGTVVDPKVFVSIAPDGIVSILAHRSEMGTGVRTSLPLIVAEEMEADWTKVRVVQ
APGDEVKFGNQDTDGSRSTRHYLLPMRQIGAMARAMLEAAAAKKLGVPASEVKAVNHEVV
HSASGKRLSFGELAADAASQPVPAVDTIKLKSPGDFRYLGKGQVSIVDLRDITVGKASYG
ADVRLPGMKYAVIARPPVTGGKVKSFDSAEALKVSGVEKVLEVKGWPWPSKFQPLGGVAV
IARNTGAAIKGRDALKVEWDDGPNAAYDSVAYRAELEAAARQPGLVVRQEGDAEAALKSA
DKVITGEYYLPHFAHASMEPPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLQIPIENVT
VNVTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTRDDDIQHDFLHTVSVERIEAGL
DKSGKVVAWRHRSVAPTILSTFAAGADHAAPFELGMGLVDMPFEIANIQCENPAAKAMTR
IGWFRSVSNIPRAFAVQSMVGEIAAATGRDQKEMLLELIGSPRVVKLASVKDLWNYGEPY
ESYPIDTGRLRRVVEFVAEKGNWGRSVPKGHGLGIAAHRSFVSYIATIVEVSVDDKGKLT
VHQVDSAIDCGVFVNPERIQSQLEGAAIMGLSLAKYGEVSFKNGRVQQRNFDDHQVVRID
EAPLVTNVHIVPADAETPPSGVGEPGVPPFAPALANAIFAATGKRLRALPIGNQLAT
>A0A839RZH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella isguenensis|TrEMBL
MPEQTFVVNGERVTVDVEDNVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
AVPVGDLSADDEVTTIEGLPAQAAEEARGDHGLHPMQEAWLERDVVQCGYCQPGQIMAAV
ALVRKVRDEGRTITDADLDGIRNICRCGTYTRIREAIRDGETRM
>A0A7W8HEU4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Quisquiliibacterium transsilvanicum|TrEMBL
MTNFSVNGQPHRFDGDPDMPLLWYLRDLAGMTGTKYGCGQGLCGVCTVWMDGEPVLSCTL
PMRGLDGRAVTTIEGLSPDGNHPVQEAWRVLNVAQCGYCQSGQIMMAAALLKTNPRPTDE
QIDEAMRGNLCRCGTYPRVRAAIRHASKEA
>A0A0U5EUM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter senegalensis|TrEMBL
MSFDLHINGAAQTVDVPSDMPLLWVLRDILGLTGTKYGCGVAQCGACTVHLDGAPVRSCL
LTVAAAAGHSITTIEAIEQTEAGAKVQQAWLDEEVIQCGYCQSGQIMAATALLQNNPHPT
DADIDDAMAGNICRCGTYVRIRKAIHRAASQDA
>A0A165RX23|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. W74|TrEMBL
MVLSLTVNGQPISVSAEADTPLLWVLRDHLNLTGTKFGCGIASCGACTVHVDGQPVRSCQ
TLIEDVEGSTVTTIEGVHGEVAQAVQSAWRELDVVQCGYCQSGQIMSAIGLLTETPSPTH
EETMTYMSGNVCRCATYPRIQQGIQLASSKLGD
>W6R2B9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas pseudoalcaligenes (strain CECT 5344)|TrEMBL
MGKIETPDSATRGILNVSRRTLLKGAGGLALGIFFAPLMRGMDALAAGGPLEPNAFVRID
LDGTVTVLAKHLEMGQGSYTGLATLLAEELDADWDKVRVEGAPADVKRYNNLAFGPMQGT
GGSTAMANSWEQMRNAGATAKAMLVAAAAQRWSVPVSEISVDKGVVSHAGSGRSAGFGDL
VEAAASLPVPEQVQLKDPKDFKLIGKLELRRKDSTDKTDGSAIFTQDFKLPGMLVAMVAY
PPRFGGVPRSVDSSKAKAVRDVVEVVEFRDLPHGRSGVAVLAKNTWAARQGRDALVIEWD
ESQAFTLGSEEILAQYRDDAGKPGLPATSKGDTDAALAQAAKTVEADYEFPYLAHAAMEP
MNCLVKLSSDRCEIWNGEQFQTVDQTIISGYLGLTPEQVSLTQLYAGGSFGRRASSVSDY
LLEAVAITKAARDKGVDAPVKMVWTREDDTRGGYFRPLYLHRVRIGLDQAGKLQAWHNRI
VGQSIMAGTSMEPFMIKDGIDHTSVEGLANLSYAVPNLQVELSTPSNIKVPVLWWRSVGH
THTGYVAETMIDEAAVAAGQDPYAFRHALLESHPRHRGALELAAKQAGWDKPLAAGAEGE
KRGRGIAVHESFGSFVAQVAEVTVKADGSYRLDRVVCAVDCGIAINPDVIKAQMEGGIGF
ALAAARHSAITLKEGRVEQSNFHDFQVLRMNEMPKVEVHIVPSAANPTGVGEPGVPPLAP
ALANALFAATGVRLRKLPFPAQIKA
>A0A654DU50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinoscillum sp. 108|TrEMBL
MAKFALTINGQERQVDVDPATPILWVLRDHLNLVGTKYGCGIAQCGACTIHLNGMATRSC
MLPVSAVGNNEITTIEGLSEGANHPVQQAWMQHDVPQCGYCQSGQIMSAAALLQSNPKPT
DEEIEGAMSGNICRCGTYVRIKAAIKTASNL
>A0A7Y9WJP5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MSPRRTDAMRGAPGVAASASRRVFLKSGLAIAGSFVLPLSFSELAWAGEGGAPSYEINDW
VRIDASGHTVIGLSQAEVGQGVYTGLPQVLADEMDADWRNVTVTFVTGRDAYRIDAANEM
PQQFVGASMSVTMFYERLRIAGAQARAAFIEAGARRFKVRGTQCTAANGQVIHIPSGRAL
SYGELVAEAVKIPLPAHPRLKPASAHTLIGQPLHKLDAPAKVNGSAQFGLDVHVPGMLTG
AVKMAPTLGGKPLRVTNADTVRKMPGVVDTVLAKDALIVVADTYWQAKLACDAAQVEWDT
PAGGPFDSATILDERKGALQSAHTVVATCLGDPQARFADAGQSSAVVVQADYHTPYLVHA
TMEPVNATVHVRDGEVEVWGPIQGQDKVRWTMAAMFKVPAAKVIVNTTFLGGSFGRKYVP
DFVVHAAVASKAVGRPVKVIRSREDDIQHGFYRPCASARMRAVLGKDGLPTALHARVVGQ
SLYKSIKPDFFDKAGGWDETMLDGIYDLCYGVPNLLVDSLHVPQPIPVSFMRSVGSTSSV
FFLESFIDELAHTAGIDPLRYRRALLRHDPLSVAVLDHAAARADWFGKSAPGLHRGMAFC
LYTGRGGAFTTYVATIVELRLVHRQVKVERVVCAVDCGRPINPMLIQEAIEGGIGFALTN
TFKSEITFAKGAVVQSNFADYPLLNLSEMPKVETVIVPSDRAPQGCGEVALPPVAPAVAA
ALFRAMGQRLRSMPLPQRFDV
>A0A3Q9E7C8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella khirikhana|TrEMBL
MSKFTAIENFSRRDVLKLFGASGGALMLGASGLGWSPMLAAQTAAFGEEQRLNLFIAIGE
DNRVYLTCHRSEMGQGIRTGIPQVLADELEADWDKVVVVQGLADKRYGSQNTDGSRSIRK
GFDKMREMGAMARQMLEQAAAERWQVPVTEVYAKAHAVYHKGSDKRLSYGELAMAAAKLP
LPDAKTLTLKTPDQFTQIGKGHTIVDMDDMLGGRAIYGADNRPEGLVYAVIARPPVFGSA
LESMDDSTARKVAGVLDIVPLPVPKGAPAFQPLGGVAVVATNTWSALEGRKALKLSWSKS
ANDSHNSKTYLDTLKQRVREPGKVARELGSQPASWPEDKMVSAIYTVPYLAHAPMEPPAV
IASVDKNGCELWASSQTPQSTQQNVAGMLGIDEDKVKVNVTLLGGGFGRKSKPDFSVEAA
FISSKINKPVLLQWSREDELRNGYLHAISAQYYQACIDDKGKVQAILSRTAFPSIGSTFD
SAVDTPQPFELDLGFTDIPWDISAVRCEAVKAESHTRIGWLRSVSNIQHGFGVGSFVDEL
AIANGKSCTAQWRELLGKARVENFANQGFEYGNYGEDQSRHPVDVGRYLKLIDRAEALMA
QKPAGKNEGWGFAIHRSFVAYAAVAIKVRLEGDKLTVVDAIALMDAGTVVNPDRVAAQME
GAVMFGLSLALFGEIDFDKGAVTQSNFHDYPLLRLPHCPQITTEIIASRAVPGGVGEPGV
PPVAPALANAIVAAGGVRYRELPLSKHLKI
>A0A7W4YZC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Microvirga lupini|TrEMBL
MIDWKSDRSRIHSLVAREDAPINKIGRNEMVSLTINGTVHQVDAEPDTPLLWVIREQIGL
TGTKYGCGVAQCGACTVHVDGVATRSCSLPISAVTSEQKIVTIEGLSPDASHPLQKAWLE
LDVPQCGYCQTGQIMAAAALLQANPSPSDGDIVAEMTNICRCGTYNRIKAAIKLAASENR
G
>A0A2N7R939|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. AD21|TrEMBL
MNVRIDPTLEAAALALHDPVNLSRRRFLTGTAVGALVLGFGLPLGATRVQAAAAATTAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPATFLVEAAPPGEAYV
VMENGMRITGGSMSVRMSYPVMRRLGALARAMLLQAGAQKLGVSVGELTTEPGKVVHAKS
GRSLAYGELAEHAMDLPVPDPASVQLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKV
DGMLHAAVQHAPRLGMTVGNLRNEDQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTADSTVRPMPADFSSDAWLKRLAADKGPAKDDEHEGDVASILKEAKTRIDATY
HNQYLNHGQLEPPSALARFNPDGSLEVWLPNQAPDMFRADIAKRTGLDPSRITLHSPLLG
GFFGRHFLYDAASPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRAALDNDG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFDLRLHLLRGNQRLTTLLQAVGELSGGWKRGPF
TGEDGSKRARGVAMASPFGTQTAVIAEVSIENGQVRVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEESVWVDGKPRARNYDLYPILPPARMARVHVRVVESGEKMGGIGEPPL
PAVAPAVANAVATLTGQRVRSLPMSRHTFT
>A0A2N9MRL1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfopaludibacter sp. SbA3|TrEMBL
MPAVKFTLNGKAQSVDAVSAMPLLWVLRDTLGLTGTKFGCGMALCGACTVHVNGQPMRSC
VTPISSVAGKSVTTIEGLSPDHSTATQLAWIAEDVPQCGYCQSGQIMTAAALLAKTKDPT
DADIDEALRGNICRCGAYDGIRKAIHRAAAMMREGGAR
>F3BET6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas distincta|TrEMBL
MSQDNKYFDLNRRKFLKTSAIGALVLGTYFVGSAPRAIAGVLEQPSEQAKRANLFIALRP
DGMVEITCHRSEMGQQIRTAIAQIVADEMEAAWDKVIVIQGKGDPKYGDQNTDGSRSIRY
NMQRLREMGASVRYMMQHAAAQYWKVDPQTCTANQHVVTHSSGKSLTYKDLIDLALTITP
PEADKLTLKTRKEWRYINTGMAHIDLADLVTGKAIFAADVREPQALVAIIERPPVVGGVI
KSFDASATKAINGVIDVIEIPAPKGAPQFQPKGGIAIIAKNTWAAWQGRKALKVVWDDGK
NGDYNSKEFKKSLLQTVQTPQANIRDKGDAMGVLAKSSNKLVADYYAPHLAQAPMEPPCA
TAMYNKDSVDIWAATQNPQADMKTVAAMLGMDESKINVHVTMLGGGFGRKSKPDFSAEAA
YLSMKVGKPIRVQWTREDDIQHGFYHAVSAQHIEASLDKNGAIESYLHRTAFSPITSTFS
EGATTPGSFELRLGFTDNPINTPNMKLENGDAQAKARIGWMRSVSNIFHAFAIQSFIGEA
AHKAGRDQKDYLLDTIGPSRIVDVTEQNATYDNYGGDKAVYPLDIGRLRHVIEKVADMSK
WGRELPKGRGLGIAAHRSFLTYVATVVEVEVSDAGDLKVIKSWVAIDAGTVVNTDTVKNQ
TQGGSIYGITTAISDGITFDKGRVQQSNFHDYRVPRMSDSPLEIDVEIVQSDAPPAGVGE
PSTPVYAPALCNAIFAACGKRIRQLPIGNQLKA
>A0A2I6QNN4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured bacterium|TrEMBL
MNGKKLRVDVDSQTPLLYVLRDHLNMTGTKYGCGEARCGACTVLVDGQSMRSCVTPVARV
GDKEVTTIEGLEKDGKLTQLQEAFLKADALQCGYCTSGMIMSATALLTKNPKPRAMRS
>A0A5E6Z0K8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIESDDVGKRVVSTWVDLQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHAAMHELAGKGDA
>A0A2U3QDF7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium vignae|TrEMBL
MPTLTINGRSLSVDAANDTPLLWAIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
MVGDVAGKKITTIEGLSAKGDHPLQKAWIAEQVPQCGYCQSGQIMQAASLLAKNPNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAASEMRTASATSSERRPT
>A0A084ENQ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium yanoikuyae|TrEMBL
MTRFTVNDRPVQYRMDPETPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCQV
TIGKTEGRFVTTIEALSPDRGHPLQQAFAAENVSQCGYCMSGIIMAASVLLRRTNDPTDA
EIDAAITNICRCGVYPRLRGAIKRAGRIMRGEDQAGDNPIQAAPPPGITPDEAVRTVPAL
RKP
>A0A5S9Q8G8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania aliphaticivorans|TrEMBL
MIRFTLNDKAVELDADGEMPLLWALRDMLQMTGTKFGCGMAQCGACTVHMDGAAIRACVM
PLSAIANKNITTIEGLSVDASHPVQQAWVQHNVPQCGYCQSGQIMSAVALLQQDPNPSDE
DIDNAMQGNICRCGTYPRIKAAIKSVASGQVMPANYELVSNAGEDA
>A0A447QSM9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MNIQINGRMVPLDDSLRDTPLLYILRNDLALNGPKYGCGLGECGACTVLIDGVAARSCSV
NAASVVGKSVTTLEGIGDAEHLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFERDPQADE
QAIKQELAFNLCRCGTHIEILRAAQRAKQIVAERGNA
>A0A102R7Z4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cepacia|TrEMBL
MPTSFVLNGKNVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTVHLEGQAVRSCV
LPLAGIAGKHITTIEGLQSKPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
ADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
>A0A090X489|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algibacter lectus|TrEMBL
MPTFNLKVNNEKHTVEADADTPLLWVLRDKINLVGTKFGCGIGQCGACTVHVDGNATRSC
LLKISQAEGANITTIEGLSEYGDHPVQQAWKEVDVPQCGYCQAGQIMTASAFLKTNPSPS
QTEIRDAMHGNICRCAAYNSIEEAVKVASEKLS
>A0A841EQJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arcicella rosea|TrEMBL
MAKYNLTVNGKKYNVDADADTPLLWVIRDHVGLKGTKFGCGMALCGACTVHLDGQPIRSC
STPISTLKAANKITTIEGISVNTDSAVQKAWIEEQVPQCGYCQSGQIMSAVALLKEKSNP
TDADIDEAMSGNICRCGTYPRIRKAIHRAAELMKDGANSSGK
>F7QKI3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobiaceae bacterium SG-6C|TrEMBL
MSMTQTTIRLTVNGNIRDVAAAPDTALLYVLRNDLELNGPKYGCGLGECGACTVIIDGVA
ARSCVIPISGCTDRNILTLEGLGSRQHPDPVQAAFIEEQAAQCGYCLNGMIMTAKALLMQ
NPQPSETEVRQALQYNLCRCGAHVEILRAVRRAAGHAVEDRE
>A0A0K3BM85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kibdelosporangium sp. MJ126-NF4|TrEMBL
MATPTTRRGFLTFLVAAPTLTLATDLTAPSAEALPSLPAPADIVDLGDVLILAGAPTSAM
LVLEVRPDGTVHFQLPRAEVGQGITTAAAMLIAEEMDIPVANVRVSLSDARAELLFNQLT
GGSNTIRSVYGPIRRTAAAARARLVAAAGQEWNIQTAKLSTKDGSVRAPDGRKATFGELT
AKAARSTAAVSAEPKPESQHQVVGTAQSRIDARAMVTGQLKYTLDLDVPGAMPTVVRKPP
TINGSVRSVDDSVAKGMPGVLAIAVVPTGVAVMAETFGQAIAAKDALKVTWNKGTVDDLS
DPDIKAKLRAAALPFIVPPLLTQHVDGEFDFAFVSHAPMETNSAIADVRGDRAEIWAGLK
SPIVAKQTIAAALGLPQDKVTVHVTQGGGSFGRRLFFDAALEAAQISKAMRRPVKLMWTR
VDDMRHGRARAASHHKIRATFALGQVLTFEHRVASVETDFRHGLGEILTATAAHLPVGNL
GFAETIFLTTVKLPYNFGVVTQLLNEIPLRMHTGSWRSVYSANTRGAEEIMVDEVAAKLG
KDPVAFRRETLKTARQRAVLDKVASAGSWGRTMPKGFAQGVAFHDEYKSCTACLVEIDAR
DPKKPRVVKAVIAVDVGRPVNPLGLQAQMLGGLTDAISTTLRAGLHIDKGLPLEGSYSQF
HYARQKDSPPQVEIHVMPANGEPGGAGELGVPAAVGAIANAYARATGIKPRSFPINFPVD
FDPFPR
>A0A5P9F2H6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter sp. THAF37|TrEMBL
MGRARTIARRTFLVGSVAVVGGVAFGAYLYKRDVKNPLEADLQPGEATFNPFVKVDAQGV
TLITPRADVGQGAYSIQAHLLAEELDVDLADVRIEPGMPSPAYYNSVVAAEGFPIAATSD
TLMARTGRGAAQVMAKVMGLQLTGGSSTVPDMYERLRHAGAVARETLLAAAARQTGLERD
QLSTQGGAVVLPDGMRLAYADLATTAAEIEPVQDVNLRDPSEWRALGRDHQRTDIVAKST
GTQPYGIDLRMEGMVHATTRTNPALGGGILGFDAGEAEQMRGVQAILPISGGFAVVADNT
WRAFRAADAVKADWGPSPYQGDSAAQFADVAASFVDDRQDSRFKDEGDVAAALEGAEVLE
AEYRIPYLAHAPLEPMSVVVRLSEGVLDIWTGTQIPRFVQDGAAAVAGLEPEAVRVHVLM
SGGSFGRRLEDDYIRQAVEIAVQMPDTPIKMVWSREEDMTHDFPRPLAISRARGAVAGGQ
VAVYDLGIAAPSVSASSLERLGQPAIGPDVAIVAGAWDQPYAIPDYRVTGYRVPPMVPVS
SWRSVGASGNGFLHECFLDELCHAAGADPLEERLRLCRHDTSRKVLEAVGEMSDWGSDPG
AGRGRGVAFTLSFGVPVAEVVEVSRTDRGIRIDKVFVAADVGRVLDPVNFEAQLSGGVIW
GLGHAMNCELTYADGVAQQDNYHVFEGMRLYQTPQIVVRGLENGDRIRGIGEPGVPPAAP
ALGNAIFAATGERIRELPFSKHVDFV
>A0A846MFX3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium vermicomposti|TrEMBL
MGRAPLKHAQRKDQARGINRRALLAGAGASAGLVLAWAIWPRNYRPNLNAAAGETIFNAF
LKIDRAGQIVVIVPQTEMGQGITTLLPQILADELGADWRTVGVQSAPVSPLYANDLLARQ
WLASDWTRLAGEAGEWAIDQYATRRALMLTGAGTSVPMFHQSYREAGAAARVLLCQAAAA
RWDVPWESCDIQNGIISDGGQKRLKIGDVVEDAAALDVPEILPFRQRQTDRLAGQDLPRL
DTPSKIDGSHNFAADIRLPDMVFASIRQGPIGDALLKSVNEDAARSVTGFLKLVRTDRWV
AAVATNWWAANKALDLADPVFELMGNPVSSEGIEAALEQAFAGSSGQRLYSRGDLAPLFD
NATIMASEFSVDPGLHLALEPMCATARVTDDAAEVWTATQAPGLARAAVADALGIADGSV
TLYSLHAGGSFGRRMDVDVGVQAALIAKDIGRPVQLLWSRLEDVIQDRPSAPAHARMAAK
LGRNGVIEGWLAKVAAPCAMTQTWDRVAHRKLPFEAARDAAGISTRLAVSGMELPYALPN
WAVDHFPADPGLPVGFAPGNARLHGAFFTESFVDELAHQAGIEPISFRIQMLGGNPRLAH
CLTTVGAMGGWQGGIEGSGQGLAAHQMDGVYAAVMVEAAINGGKLSVGRIIAAVDGGDQV
NPDIARQQVESGLIYGLAIAMGASVPYARGMPRRAIMGRMDLPRLADIGEVSVELVRSSA
PPAELTDIGAPLIAPAVANALFTVTGQRFRKLPLLPRT
>A0A0D6JE51|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Filomicrobium marinum|TrEMBL
MTTVTVNGKEMQFDGDPEMPLLWFLRDIAGMTGTKFGCGAALCGACTVHLDGTAVRSCQT
TLADAAGKQVTTIEGLDPEGMHPVQVAWRELNVAQCGYCQCGQIMQAASLLKDTPQPTDD
DIDAAMSGNICRCGTYPRIRAAIKLAASKLGDAR
>A0A846M5I3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium vermicomposti|TrEMBL
MTKFTVNDRPVQYRMDPDTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCQV
TIGYAEGRFVTTIEGLSPDRGHPLQQVFAADNVSQCGYCIPGMIMTAAVLLKRNNDPSDD
EMDTAITNICRCGIYPRLRAAIRRAGRIIRGEEQVEAAPPPGITPEEAARTVPALRRL
>B9BRW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD2|TrEMBL
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCV
MPAVAVQGRHVTTIEGLSPDGRHPLQLAWVAEDVAQCGYCQPGQLMQAAALLNGGRPVDD
AAIVSAMSGNVCRCGTYARIHRAIKRAASGDPALDAVAGDAKEA
>A0A839PI95|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. RMAD-H1|TrEMBL
MTSFTINGRTVEVDAAPDTPLLWVIREHLKLTGTKFGCGIAQCGACTVHVDGAPTRSCVT
WLEDVEGRKVTTIEGLSPDASHPLQKAWIAEQVPQCGYCQSGQIMQAAALLESTLNPTRE
QIIEHMDGNICRCGTYVRIISAIQRAAREA
>A0A0D1EBR5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia aquimarina|TrEMBL
MTISLNINGETHEVEADPGTPLLWVIRDELRMTGTKFGCGVASCGACTVHLDGQPARSCQ
TYVGDLEGTEITTIEAMRENEIGAAVQQAWMELDVVQCGYCQSGQIMSAVGLLSENPKPS
AEEIDNYMYGNACRCATYQRIRAGIQRASEILEA
>Q13NR4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia xenovorans (strain LB400)|TrEMBL
MTTLNINGQTHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDRKITTIEAVGSTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLLTSNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGA
>G0EYX5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MTATNLQAAAQADADTPRTLRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
IFIALRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLERVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAAQHLGVEAGGLEAEDGVFRVPGTQASVGYGALL
AGEHLELPLADDIPTKPVESYRIVGRAAGRVDIPGKVRGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGHFVGNSLLEVDRDSVRDVPGVVDVVVQGDFVGVVAEREEYAVQAARRLRVRW
KPIPPLPALDDPEPALRANPATRRELLADGELPANGAGMALQRRFVWPYQMHGSIGPSCA
VADWHDDGLTVWSGTQNPHVLRIDLAKLCGLGEDRIEIVRMEAAGCYGRNCADDVGADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGPDGALLGYDFTSRYPSNDAPTL
ALVLTGAVPNAPRTLEMGDRTAVPPYAYGARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELAAEAGADPVDFRLRHLPDERAAALLRAVAEAAGWQRGVAGSRGIADAEGWLRGR
GVAYARYIHSRFPGFGAAWSAWVVDLAVDAGSGRITIEKVVVGQDTGMMVNPDGVRHQIH
GNVVQTLSRVLKEQVRFDAEGVASREWGSYPLLTFPEVPPIEVVLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAGLQAR
>A0A7W6JTP6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kyeonggiensis|TrEMBL
MKSPPESLDPTQPAKRGFRMTRRRMVLGGSLIGGAMVVGYTATHPMEVGGAILSGGGPDP
EPSAFGSYIRIASDGFVTIVNRQQELGQGIHAGLAAIVAEELDADWDRVKVIDSRSNFRT
YGPQGSVGSRSISSNWDLMRNAGAAARSMFVDAAALLWRVPRRLIDVRDGVVSHPGSNRS
ATFAELLADASRQAPPQQPMLKQTKDYRLIGTDRVRRKDSVPKSTGAQVYTQDVQRPDLL
VAMVAHSPRFGGKLARFDPSDARKVKGVIDVFAIETGVAVVAQNSFAARKGRDALRVEWD
DSEAEKRSTPDLFRYYHDLAAGRGDVSPSDFAMKGDKPEAPFSGDIFEFAFDFPYLAHAP
METLDCVAAVNGWDVSITSGAHLPIVDQVQAALTARTTPGRVDLEVIPAGGSFGRRGVMS
ADYVVECVRIAKRTNGRPVKMIWTREDEMMAGYFRPMSHHRLWVQMGHDGFPRRWRVHSV
CQPLVPVGPNSQAVEGIEGSPYFSTASTVDGKIFSPSFAVPPSFWRSVGHSHTSFVMEHI
IDQLARRAGRDPAAYRRTFYEKAGDKRRLAVLETLCRRSGWGEPMEAGWARGLAIHETYG
TLVGQVAELRLDRGKPVVRRVVAVTDCGIAVSPNQIAAQMEGGIGFGLSAALSGSMTLKD
GIVQETNFDTYPILRMNEMPAVETHIIASTNRPTGMGEPGVPPIAPAVANALLALTGNPT
RSLPLAQASTISNAPGDPA
>A0A840R7H0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania antarctica|TrEMBL
MADLEFTLNGQQQTLSVDDGTPLLWVLRDHLAMTGTKFGCGMGLCGACTVHLDGSPIRSC
SYPAEFVNGKAITTIEGLASSDENLHPVQQAWLEMNVPQCGYCQSGQIMSAVALLANNSA
PNDAEIDAAMAGNICRCGTYPRIRKAIHRASELAVVQHYQPANTVKENV
>Q1D2Y2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Myxococcus xanthus (strain DK1622)|TrEMBL
MTVRVRINGEEKELDVDPEMPLLWAVRDVLGLTGTKYGCGQALCGSCTVHLDGQPVRACV
TPIRRAEGHSVTTIEGLSPDGNHPLQKAWVELGVPQCGFCQTGQIMCAAALLAKKPQPSD
KEIDQSLAGNLCRCGTYTRIRSAVKKAAGMSEE
>A0A7G6UYA8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MITLTVNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRACIT
PVAVAAGKRVTTIEGLSTELTHPLQQAWQELNVAQCGYCQSGQIMQAASLLKTNPHPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAVRRGGAA
>J2YDK0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens Q2-87|TrEMBL
MLNEIFPQETPRALQQMLERDAGDGPATLARRSFLKIVGIGGLALGAFPHLALAQQAGDG
QAVLKPTQQPAAFVQITPSGEVTVTINRLEFGQGVQTALPMILAEELDADWSLVRTRNGS
NDAAYMDPSFGIHLTGGSNSIKNSYTQYRELGARARAMLLAAAAARWNVDVASLTTEAGK
VLGPGGRQASYGELAEAAMAMPVPEQVTLKDPKDFRIIGQATTRIDAKAKSSGRQDFGID
MHLPGQLTAVVARPPVFGARIASLDDSAARAAKGVKAVFRVPLDRGAEGVAVVAESYWQA
KTARDALKVEWDVSRVEKVDSDKQLLQYRELADQPGPLHFDADMAPLATAPHRLDAEFLF
PYLAHAPMEPLNCTVQLAEDGAQLWVGTQFPGGDGAAAAKVLGLKPEQVQVNVQTAGGGF
GRRGVPTNDFAVLACEVAKGARAAGFNAPVRTLWSREDDIKGGYYRPMHLHRARIGFDDS
GKVLAWDHALVGQSIITGTVFGGRVKNGIDPTATEGLRDPYPLPMRLTVHHPELNVPVLW
WRSVGSTHTAFVMETLIDEIARTTQQDPVAYRMKLFGDQSPRHREALQLAVDKSEYGKRQ
LAVGHAWGVAVHESFSSVVAYVVEASVQDGRPVLHQVTAGVHCNLVVNPRSVEAQVQGAA
LMGLSMCLPGGAITLKDGVVQQSNFADFSVPRITDMPAFAVHIVPSAEPPTGMGEPGLPA
LAPAFANAIASLTGKPIRQLPFKLA
>A0A7W5HNI5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. Tn43|TrEMBL
MDHLNPVSRRGFLKGSAVLGGGLVVAFVIPGANRFALGAENQGNVFAPNAFLRIGNDNSI
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAADYGLPGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIEAAAKRFDVAPSQIRTESGVVMAGDKRATYGELADDAGKL
PVPDPATIKLKEAKDWTIIGKPTQRLDTPEKITGQAKFGMDVQFDGLMTAMVARPPVFGG
SVKSFEGAEALAVPGVHKVVQVPTGVAVIADHYWAAKLGRDALRVEWDLGPNAGLDSQQL
LESFRKLAATPGASASQAGDATATLGKAAKTIEAEYSVPYLAHAPMEPLNCTVKLSKDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVSEAVYVAKAAG
APVKTVWAREDDIRGGYYRSAFLHQARIGLGTDGMPVAWKHVLVGQSILTGTSFAATMVK
NGVDKTSVEGVADSPYLVGLANHQVELHSPQTGISVLWLRSVGHTHTAFVMESLIDELAD
AAGKDPVEYRRTLLKAHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQENLAIRVHRVVCAVDCGIAVNPQGIAAQMESGITFGLGFTLHSKLTFKHGQVEQSNY
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGEVGVPPVAPAVANAVFALTGQRLRELPLQLS
GV
>A0A7W5HNH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. Tn43|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSADGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPSD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A095VRA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudohaliea rubra DSM 19751|TrEMBL
MADTTNIGSLSRRAFLKSSGAAALLVGFALPGGSGSRAARAEAPLQVNAFLRIDTDGTVT
ILANHSEFGNGAYTIIPMLVAEELEVPWESIRLEAAPTRPEYYSPVFGEYLTAGSITVFS
LWEPLRTAGAQAKAMLMDAAAAEWDVPPEQVTAQVGVVRAGDRQAGYGELVAVAQARNIP
LRESVTLKTPADFTVLGRDRRRFEGRSKVTGEARFGIDIKLPGMLYASILRSPAYGGRPQ
SFEDSETLKVPGVVKAKAISNGVAVLATNYWSARKGRDALTVTWDEGPNTGLSSEGFFEE
YRVLADKPGMLAEDIGDSLSVLAAVQKPLEAVYELPYLAHVTLEPMNATARVETDRCEIW
SGTQYQSNDQERVAALLGLPQQAVTIHRPLMGGSFGRRSSKTADFTIEAVEVARGESVPV
QVIWSREEDVRSGFYRPLFVHKLRGTVDDDGMPLAWHQTVVGQSIMQHTKHDPAYMVDGM
DIYSLDGCLQEPFGVFSYGTSYAIPNHRVETHNPPKVGVAPQEWRSVGHSHTGVAYECFL
DELAYAGGRDSFDVRQHLARGNARMSAVLAMLREKSDWDAPLPEGWGRGVAARVYSVTPI
AQVAEVSTDDGNYRVERVVCVVDCGFAVNPLNIEAQLQGGIAMGLSAVAGEEIVLERGRI
LQSNYHDYPVLRLNQMPRIEVHIIDSQEVPTGVGEQALAPTAPAVLNALFAATGRRIRRL
PIRHHGLQLS
>A0A1J5SGB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MVARLREVPALHSIALMTPLRFTLNGQVVELNDQDPSTPLLWVLRDRLGKTGTKFGCGIA
MCGACTVHLDGVAVRSCSVEVGTIAGRHVRTIEGLAEAEGALHPLQEAWIEHDVAQCGYC
QPGQLMQAAALLAKHPNPSDDDIDAAMSGNLCRCGTYVRIRAAIHSAAAKLAAKGGAA
>A0A238H0R5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia singularis|TrEMBL
MTNHLDLPETDAVRASRRTFLKAAGAIAAAGLTIGFEWPDASRAAQAAASPGADAFTPNA
FLRIAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWRDVRVESAPADAERYANLQWG
KLQGTGGSSAMANSWMQLREAGAKARAMLMSAAAARWRVPVAELSTRDGVVGHAASGRSA
TYGALANAAAELPVPDKVALKSPADFRLIGKPVPRVDAAAKSNGTAQFTIDVAQPGMLVA
LLQRPPLFGATVKSFDASAAKAVPGVTSVVQVPRGVAVVATGFWAAKQGRDALQIEWDDA
HAEKRSSDTIMREYRQLAERAGASARRDGNVNSALAEAAKRISASYEFPFLAHAPMEPLD
AVVKLTADRCEIWAGDQFQTIDQENAARAAGLAPKQVFIHTLYAGGSFGRRANPASDYIV
EAVSIAKALGANGTPIKLQWTREDDLHGGRYRPMYFHKLDAGLSADGKLVGWRHRIVGQS
IVAGTPFAAGLVKNGIDATSVEGASNLPYAIPNISVELTTTQTGVPVLWWRVVGSSHTAY
AVEAFIDEAAHAAGKDPYRFRRDMLAHEPRMRAVLDLAAEKAGWDSATPLPKGRGRGIAV
AEAFKSYVAQVAEVLVDEQGAVKVERIVCAVDCGTAINPDVIAAQMEGGIGFGLGAALKG
AITLKDGKVEQNNFDGYQVLRIAEMPKVEVYIVPSGEAPTGVGEPGVAPVGPAVANAIFS
ATGKRTYTLPLSAPDQHGSV
>G8Q236|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas ogarae (strain DSM 112162 / CECT 30235 / F113)|TrEMBL
MLNEIFPNEQPRALQHMLERDEADGPAALPRRSFLKIVGIGGLALGAFPHLALAQEANGA
AAAPLKPTQQPSAFVQIAPNGEVTVTINRLEFGQGVQTGLPMILAEELDADWSQVRSRNG
SNDAAYMDPAFGIHLTGGSNSIKNSYTQYRELGARARAMLLSAAAARWNVDVASLSTQAG
MVLGPAGRKASYGELAEAAMAMPVPEQITLKDPKDFRIIGQATTRIDAKAKSSGQQNFGI
DMHLPGQLTAVVARPPVFGARIASLDDGAARAAKGVKAVVRVPLDGGAEGVAVVADSYWQ
AKLARDALKVEWDASAVEKVDSEKQLAQYRELAGKPGPLHFDADMTPLTSAPHQLDAEFV
FPYLAHAPMEPLNCTVQLAGDSAQLWVGTQFPGGDGAAAAKVLGLKPEQIQVNVQTAGGG
FGRRGVPTNDFVVLACEVAKAARTAGVNAPIRTLWSREDDIKGGYYRPMHLHRARIGFDD
SGKVLAWDHALVGQSIITGTVFGGRVKNGIDPTATEGLRNPYPLPMRLTVHHPKLNVPVL
WWRSVGSTHTAFVMETLIDEIARTTKQDPVAYRMKLFGEQSPRHREALQLAVDKSEYGKR
QLPAGHAWGVAVHESFSSVVAYVVEASVQDGRPVLHNVTAGVHCNLAVNPRSVEAQVQGA
ALMGLSMCLPGGAITLKDGVVQQSNFADFSVPRITDMPTFAVHIVPSAEPPTGMGEPGLP
ALAPAFANAVASLTGKPLRELPFKLA
>G8Q235|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas ogarae (strain DSM 112162 / CECT 30235 / F113)|TrEMBL
MSALNINGREYTVDVDPSTPILWTLRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGKKITTIEAATNGSDPVGSAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTAAEIDSAMAGNICRCGTYARIRAAVADAAKTLA
>A0A0J7LYE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter subterrani|TrEMBL
MALNRRNFLKVSAGASGSLVVSLALPGCSGIQTGYKPESGEWRPDAWLELTETDDVFFTL
ARVEMGQGTYTGLTTLIAEELEVAPERITPRFAPVADEYRNPLYKLQLTGGSTSMATSWE
PLRIAGAQARQMLVMAAARVWKVDAAECSASEGRVVHPNGMDSMAYGKLVKLAAKEVVRG
DIALKPRHEWKYIGKNRGKLDARAKSTGTAVYGIDMELPDMVYGVIARPSRHGGRVLGFN
GDEVRSMTGVLDVFETDRGVAVVADKYWRARKAQEALTVDWDFSGALSVSTDDVFASYRA
AADDNPGESERSEGSFDGVLEGADRVLEAEYAQPYLAHATLEPMNATAWYRDDHMEVWAP
TQAPDLGRIAVARATDLGPEDVTIHTTFLGGGFGRRLTQDYIEEAAALAYRVRRPVKVIW
SREEDTRHDLYRPAMLHRMKASLSGGELTGWHHQIVGPQILGWFVRNAAPAQFPWAPKFM
YDTLGKVGLMAEGIATPKDMSAIEGAIEYPYQVDNIDIRHTHTDPGVPITWWRSVGYSHN
GFAVETFMDELAHESGEDPYRFRRRLLASEPRYLAVLDRAARLADWAEPAPQGRARGIAL
MRSFGTYVAQVVEAGVENGAIRVYKVACAVDCGQVVNPRIVEDQIEGGILFGLTAALYGE
ITLTNGEAQQSNFHDYRLMRQYERPEVVVDILDSAEAPTGVGEPGVPPVIPALGNALFAL
TGKRQRRLPLKAEG
>A0A1J5TJ97|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MKNTTLQDSSRRAFLKDGALLMGGLVISFYMPVKGGRAFAAEAQPKAVFPPNAFIRIAAD
NSITIVVNKSEMGQGVYTSLPMLVAEELEADWSSIRIESAPVAAVYNHTGFGMQLTGGSS
SVPSSWEQLRRVGASGRIMLIRAAAGQWGVPESECHAENSQVIHARSGKRLSYGELADAA
AKLPLPDSVELKSPKDFKLIGKPVKRIDTPVKINGSAQFGLDVYLPGMLTVLIARSPVFG
GKVKRYDATEAAKLPGVQGIYQVPSGIAVAASGFWPAKTARDLLEIEWDEGPGAALSTPK
MRMEYLELAKQPGTVARKDGNTEQGFKEAHKSVSAEYEVPYLAHATMEPLNVVVDLTPDH
CTIWTGTQAQTMDRGMAAATAGLKPEQVEIHTMYLGGGFGRRANPRSDFVQEAVQVAKVI
GKPIKVVWAREDDMRGGYYRPMWADHIEVGIAKDGRPVAWKHTIVGQSITADTMFESFMI
KNGIDATSVEGASTLPYMIPNLQVELHSTRNVVPVQWWRSVGHSHTAFVVETMIDELAHL
AGKDPVAYRLDILPAASRYRGALKLAAEKSGWGKRKLPAGHAYGVAVHQSFESYVAEIAE
VSLENGKIKVHRVVAAVDCGMVVNPDGVQQQVEGAIVYGLSAALHGAITLENGRVMQSNF
DSYAPLRYSEMPQVDVHIVASNERPTGIGEPGTPPIAPAVANAVFALTGKRLRRMPFDQE
TLA
>U2XWH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MSSGLRKVILSLSVVIIALIGGWFTFSFLAENGHLGSERDRGIIQGAAIPDNIVLARQTA
ESSVAPTPYRKQIMFGDLHVHTTYSTDAFLWSLPLYQGKGLHPLADACDYARYCSALDFW
AITDHAEASIPERWENAKQSIRECQAKSNDQSNPDMVSMIGFEWTQVGITPETHYGHKNV
IFKGLDDKDVPVRTIAAAGITSLALRNNAKGMPAIVSLMEFQDRQIYWDFNTFFNNIQDV
PECDTNTPSNELPANCYETAVTPGDLIRKLRDEQNLDPLIIPHGTSWGLYTPHNTTWDKQ
LKPENRPEEYSLIEIFSGHGNSEEYRDFETLIIDDDGKAICPPATEDYTPSCVRMGEIVE
ERCLAEGTSSEECTLRASEAREIAAFMGPSYHLAIGGDSAADWLLSGQCTDCYLPAFHHR
PLTSVQAGLALSRFDEDADNPTRFNWGFISSSDNHRARPGTGYKEFGRRLNTEAAGPKSA
EWLERLQPEMTPVDAYVHPLDPNELAKNANLGLAEVERQSSFWLTGGLAAVHTEGRSREE
VWDAMQRRETYGTSGPRMLMWFDRVAEDGTETPMGSSVSTTSSGTFKVKAVGSFKQKPGC
PDHAIAALGAERLNDICGGECYNPSDERNLIERIEIVRIRPQTSPDEKLGDLIEDPFIVH
NCPADQNGCSFTFTDPDFKAGERDTLYYARAIQEPWPTINAEPIKCEYDEEGNCVKAKVC
TGDYRSGDDECLTMKDVRAWSSPIYLNYGASSSTVSSK
>A0A482ZFP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MDRFLGFVCCDLRIDLSRLHSNSTQRVLLTCCDLRIDLSRLHL
>Q07GL3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter denitrificans|TrEMBL
MTTTSNLSRRSVLKGGAGLFFAVGAGGVSAVSALAQANTGLAVNPWLSIASDGVIKIVFP
STEMGQSSYSTLPQILAEELDANWDDVVIEQLNADDRTFGNPLFGGVLYTAGSTGVQSYY
DPMRRAGAQARDVLLQIAARELGVPKESLHTEPSAVVAEDGTQLSYGNLAAAGTTGVDIP
SADSLALKDPQDFRIIGQDIPRRDVPAKSTGNAQYAIDVELDNMAHATVLRAPVEGETPL
TLDDTDARAVNGVFDIVTLPDGVAVVAESLWAALGARSLLQVEWSTTSPARGFNSEATLE
AYAAAAQDAQSEPAIWAERGDAPSAIANAERQISHLYLSDYAYHAQIEPMAAVASVDADG
LGAEVWAGTQTQSWTTQTVMQTLGTTQDRVRLNMMTMGGSFGRRTAFVQEYVRDALLCSK
AVGRPVKVTWTREDDVKNGTFRPAAAQHLEAGLTADGRLSGWHHKVATPSVIGFFNPGRW
EAVKPNDVISMRGAESKFYTIPDFRADHIITERDARLAPYRGIGAAYTSFAAEAFMDELS
EAAGRDPLDFRLDLVAENPRGRHLLEKVAEMSDWRNRGTRALGLSFAGYSSSMAAGVAEI
EVDESSGDIRVKHVWAAVDAGRIVSPDNAHNQIEGGIIFGLSMALTEKIDIENGEVVQNN
FWDYEITRADRVPPIDIYMAEVDAPPVGVGEVGTPMVSAAIANAFYAAKGRRLRHMPFTR
ERVNAAIQT
>Q07GL3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter denitrificans (strain ATCC 33942 / OCh 114)|TrEMBL
MTTTSNLSRRSVLKGGAGLFFAVGAGGVSAVSALAQANTGLAVNPWLSIASDGVIKIVFP
STEMGQSSYSTLPQILAEELDANWDDVVIEQLNADDRTFGNPLFGGVLYTAGSTGVQSYY
DPMRRAGAQARDVLLQIAARELGVPKESLHTEPSAVVAEDGTQLSYGNLAAAGTTGVDIP
SADSLALKDPQDFRIIGQDIPRRDVPAKSTGNAQYAIDVELDNMAHATVLRAPVEGETPL
TLDDTDARAVNGVFDIVTLPDGVAVVAESLWAALGARSLLQVEWSTTSPARGFNSEATLE
AYAAAAQDAQSEPAIWAERGDAPSAIANAERQISHLYLSDYAYHAQIEPMAAVASVDADG
LGAEVWAGTQTQSWTTQTVMQTLGTTQDRVRLNMMTMGGSFGRRTAFVQEYVRDALLCSK
AVGRPVKVTWTREDDVKNGTFRPAAAQHLEAGLTADGRLSGWHHKVATPSVIGFFNPGRW
EAVKPNDVISMRGAESKFYTIPDFRADHIITERDARLAPYRGIGAAYTSFAAEAFMDELS
EAAGRDPLDFRLDLVAENPRGRHLLEKVAEMSDWRNRGTRALGLSFAGYSSSMAAGVAEI
EVDESSGDIRVKHVWAAVDAGRIVSPDNAHNQIEGGIIFGLSMALTEKIDIENGEVVQNN
FWDYEITRADRVPPIDIYMAEVDAPPVGVGEVGTPMVSAAIANAFYAAKGRRLRHMPFTR
ERVNAAIQT
>A0A7W5G4C2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas organivorans|TrEMBL
MTTLTINGQTHEVDAPDNMPLLWAIRDLVGFTGTKYGCGRGLCGACTVHLDGQATRSCIT
PLSAVGDREITTIEAIADDPTGASVQQAWRELDVVQCGYCQSGQIMSATALLQGNPAPDD
SAIDGAMSGNICRCATYVRIRAAIHQAAASLGQEVS
>A0A5P8Z013|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax sp. THAF197b|TrEMBL
MSAKDITRRVFLAGSVAIAGGAAFGIYAARRPHDNPLEAKLSAGAAALTPYVKIDASGVT
LITPRADSGQGAYHVQAALIAEELDVDLENIAIDPGPPDAAYWNGALATEAAEFMVPAAG
LVRNATEATVATALKVMGLQITGGSTTVPDAFDKLRAAGASARETIKAAAADRLGVDAMD
LSTEAGHVIAPDGTRIAYTELAADLSGRAVVQDVPLRAPETWRYINKGIQRLDIVPKSTG
TQAYGIDANLPGMVHATVLMNPAQGGALDSFDTAEAMKLRGVQAVIPITGGLGIVADNTW
RAFRARAAIAATWGKPDFPTEQADHWAALEAAFTEDARDSRKRDDGDVEANLGSEAISAE
YRAPYLAHAPLEPVNAVVRVDEDGAEVWTGTQIPRFIQRNVARITGLTPDQVTVHVLAMG
GSFGHRLEDEVVKQATEIAMQMPGTPVKLTYQREEDMIHDYPRQIAMARMRGAVRDGQVE
ALDLGIAMPSVMASQMARQNQPVPGPDSQIVAGAWDQPFAIPHQRVTGYRAQPLAPISSW
RSVGASSNGFFYNAALDELIHAAGADPLQERLRLTSDPLARAVLETVGEMADWSGPNPAP
GRGRGIALTRSFGVHCAEIIEVSDTEDGIRIDNVWVAAEVGRVVDPVNFENQVQGGVIWA
LGHAMNCEITYAGGVAQQDNYYAHEGMRMRQAPRITVRGLENGDRVTGIGEPPVPPAAPA
LAGAIFAATGTRLREMPFNKFVTFA
>N1MSX8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium japonicum BiD32|TrEMBL
MTRFTVNDRPVQYRMDPDTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCQV
TIGKTEGRFVTTIEALSPDRGHPVQQAFAADNVSQCGYCIPGMIMAASVLLRRTNDPSDG
EIDAAITNICRCGIYPRLRGAIRRAGRIMRGEDTGIGEQGAAAPPPGITPEEAARTVPAL
GRPAPQPKR
>A0A0F7M078|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Spongiibacter sp. IMCC21906|TrEMBL
MSAMQKGLSRRLFLIRSAQAGAGLTLGMSLSGQLLAASGDKHENFEPNAFVSIQPDNTVV
ITIKHLEMGQGTYTGLATIVAEELDADWAQVKAVAAPANTKKYANLAMGVQLTGGSTAIA
NSYTQMREAGATAKAMLLAAASKQWNKPVASLSVKAGKVMHAASGKEASFGELADAAAQQ
PVPKDVKLKDPSEFVLIGKAKLARKDSGKTDGSAIFTQDVQLPGMLTAVVAHPPLFGATL
KSVDASAAKKLPGVKAVVEIPSGVAVLADSFWQAKKGRDALQLQWQGGSKRSSQEIIADY
KKLADKPGLSATKNGNVTPALESGKHVVEATFEFPFLAHAAMEPMNCALQKNAKGVEMWY
GCQGHSWDQKNIAKVFDLDPEAITINTLYAGGSFGRRATVVSDYPVELAEIVKAWGGSEP
VKLVWTREDDTQSGYYRPIYVHKLKAALNDAGELDAWQQRIVGQSIMGAGKSVDHTSVEG
ASNLPYNIPNLSVESHNTSEEVPISWWRSVGSTHTAYAVEVFIDELAKKAGRDPVAFRLS
LLKDEPRHAGVLKLAAEKAQWGKALPEGHFHGVALHKSFGSYVAQVAEVAAQKDGKFKVV
KVTCAVDCGVAVNPDVIAAQMEGGIGFGLSPLMFSEVTLKDGKPEQINFDAYKVVRMRHM
PQVDVHIVPSAEAPTGVGEPGTPVVAPAVANALFAATGKRIYSLPAGGDFFAA
>A0A0F7M8D9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Spongiibacter sp. IMCC21906|TrEMBL
MKINTELNRREFLRITALAGGGLLVACGGGGSGGSQTADDNGGPGVGNGGEASTPAEEYD
VGAFMRIDTDNQVTILVGAAEIGQGALTSLPMIVAEELDADWSKVRSELSPVAPRFNNPY
YVGALQFTVASSVVRGYFEPQRKVGAAVRQMMVNAAAKRWNVNADSLRTESGMVIDEANG
RSTSYGELASAAAQEPIPFNPRLKSPDDYRIIGKSKQRLDVNGKVDGSFQYGIDVDIPDM
LTAIIVRPPRFGGQALNYDRNTVMAVPGVVDVITILGGVAIVAEDYWSATKGRQALQVNW
AELLAGRTDSQAQRNEYGFKLNLPGVPLRIDGSTLLANTFAKEVISEDYYFPYQAHAAME
PLNVVIDYRGNSADIWTGTQSPTVDKIIASTILGLLPGQLNFHVMPAGGGFGRRGNLLAD
FVRDAALVAKVIQRPLKLIWSREDDMKGGFYRPAAMVRVSAGLNDAGEIISWSHRAITQD
VTAALYTEELTDLLLDFKLPALTDLTDLENGMPYDIDNVLVDFHLTVKPNMPALWMRSVN
KYTDVFAQETLIDKVAQQAAQDPYQFRRGMLTNKPRHRAVLDAVAQAANWGSPPSGQFQG
IAIMGHWGSFVAQVVEVSVDSQRRLTVHRVVTAADCGTAINPDLVIAQLESAVIFALSSV
LFGEIELVDGVVQQNNFDDYPVVRMYQAPEMETVLVNSGDNPGGVGELGVPCVGPALCNA
IFAATGELITELPLKNLNFDIA
>A0A0K8P7W0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MRRRAWLLSGVAAGGALLVGWSVLPPRGRLGAPERLGTTRDAVALNGWIRITVDGRVELA
MNRSEMGQGVHTALPMLVAEELDVPLDRVVPVPAGHDALYGNVAAFVGSLLPVHPRDEQP
GAETARVRVGRWMVSKVARELGINMTGGSSSVADAWEVLRLAAATARAQLLGAASLAWKL
PVAEFAVVDGVIEHAASGQRAAYAVFARAAAITPPGEVRLKPAAAWRLIGTSAPRTDLPA
KCDGRARYGIDLRLPDQLFAVVRHAPMLGGWPGRIDGIDEVLRRPGVVRVLRLPPYAGGH
AAVAVVGRSVWHARQGAEALRIDWRAPPAGGPDSAAIADRLARAAREGGEQGGGVAFHSR
GDVDGDAARGVREFAAAYRTPYLAHAAMEPLNATAQVRDGRIEVWVPTQVPGLARALAAR
VAGVAPEAVTVHVTLLGGGFGRRLDTEVVGQAVRIAQECQGRPVQLVWPREEDMTHDVYR
PAGAAWMTARLDARGQPVSIRWTSAGDAISPRWMERNLPALAGPVDTPDKTTGEGLFDSP
YAFPHQRIAHVATRSGVPVGFWRSVGHSHNAFFKEAFVDELAAEAGQDPVAFRLAWLREL
PRHAEVLKRVADEAGWPGFRGGGKPLPAGRARGVALHESFGSIVAMVVEASLDEDGPRVH
RVVVAADVGTVVNPGIVRQQLEGGVVFGLTAALHGRIDIVGGAVQQTNYPAYRLLPLART
PRIEVHLLASERPPAGVGEPGVPPVAPALANALHALTGRRWRELPLMPPPAAPPAGGGAG
VPPLSAAPR
>B9NNE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium KLH11|TrEMBL
MATALKINGKTHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGESVRSCQ
VALSDVWGEVTTIEGLGTPDAMAMIQQAWVEHQVAQCGYCQSGQIMQAAALLAENPSPTD
QDIDDAMQGNLCRCGTYPRIRAAIHDAASKLNEA
>A0A3G7C3F1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MELRINQKAYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIETNEVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTAAPSDA
QIEAAMVNLCRCGTYNAIRTAVHDLAAQPAKKESA
>A0A447KN00|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera|TrEMBL
MKLQINETSYEVDAEADTPLLWVIRDDLGLTGTKYGCGLAQCGACTVLVDGVAVRSCVTP
IEGVAGRAITTIEAIETDEVGKRLVQAWISHQVPQCGYCQSGQVMAAAALLKQTPHPSDE
QIAAAMINLCRCGTYNAINAAVHEAATAVTTPDSAVGRGAEQTWTPTHSGAAVATSALAL
AGNDVFHRQPQSVRANDEESGV
>A0A3S5D6Z2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera|TrEMBL
MLHAAVQHAPRLGLTVGSIRNEQQVTSMKGVHSVHRQEGAVAVVAQRWWTAKRAAESLQV
DWNDPGAETSVRYMPADFSSAAFNDRLANETGAGQDAETEGDIHQALTNAHQVVSATYRS
QYLNHAQLEPPSTLARFNPDGSLDLWLPNQAPGMFQADVAKITGLGLEQIHIHSPLLGGF
FGRHFLYPTATPYPQAIQLAKAVGKPVKLIWSREEEFLRDVLRPMAAVRFRGGLDEQGLP
VALEAISATEGPTEGVANKQGDALDPTALEGLSGKAYAIPNKRVAQLYVKNPVMLGYWRS
VGNSMNDFLYETFLDELADKGGQDPFALRMHLLKGNSRLSNLLQAVEALSGGWKRGPFTA
EDGSRRARGIAMASPFGTEVAVIAEVSIEHGQVKVHDIWQAIDPGSIVNPALVEAQVNGA
VALGLSQVLLEEAVYKNGMPVGRNYDLYPILPAHRMARVHVRIIESGAKMGGIGEPPLPA
VPPAVANAVSRLTGQRIRSMPLSHYHFDSEKML
>A0A383RU79|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas reidholzensis|TrEMBL
MLNDLFTPELPRALQHLLERDQDDGALTLPRRSFLKIVGIGGLALGAFPHLALAQEATGG
DAALLKPSQQPAAFVQIDSSGQVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
SNDSAYQDPIFGMHLTGGSNSIKNSYTQYRELGARARAMLLAAAAARWNVEVTRLSTHAG
KVRGPAGLEASYGELAEAAMALPVPDEVTLKDPKDFRIIGQATTRIDAKAKSSGQQDFGI
DMHLPGQLTAVIARPPVFGARIASLDDSAARTTKGVKAVLRVPLDGGAEGVAVIADGYWQ
AKLGRDALKLQWDLASVEKVDSQQQLIQYQALADQPGLTHFDADMAPLATAKHVVEAEFV
FPYLAHAPMEPLNCTVQISGKSAQLWVGTQFPGGDSAAAAKVLNLKPEQIQIHVQTAGGG
FGRRGVPTSDFVVQACEVAKAAQSVGLNAPIRTLWSREDDIKGGYYRPMHLHRARIGFDD
SGKVLAWDHVLVGQSIITGTVFGGRVKNGIDPTATEGMRDPYPLPMRLTVHHPTLNIPVL
WWRSVGSTHTAFVMETLLDEIARATKQDPVAYRMKLFGEQSPRHRQALQLAVDKSGYGKR
QLPAGHAWGVAVHECFSSVVAYVVQASVQNGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
ALMGLSMCLPGNAITLKDGVVQQSNFADFSVPRITDMPEFAVHVVPSAEPPTGMGEPGLP
ALAPAFANAIASLTGKPIRELPFKLA
>A0A0M6YQA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia donghaensis|TrEMBL
MHPILKPAFAPRPTRRGFLTGSAGLVLGLHIVGKARAQSAATADGDFAPNAFIRIAPDNT
VTVLVKHIEIGQGANTGLPLLVAEELDADWSQMRAEQAPSDPVVYVNTAFGVQGTGGSTG
LSNSYMTMRQAGAAARAMLVSAAADRWGVLPEGITVSKGVVSHADSGNSATFGDLADAAA
LTPVPVDVALKDPKDFTLIGGDKVTRLDGHAKSTGQAMFTIDVFRDDMEVVSVVHPPKFG
ATVASFNAATALARPGVTAVRELSSGVAIYADDTYSAFKARADLDIEWDESGAETRSTDA
IIEEFTAAARAPAMVAEQTGDVDAALAGADRTIEADYVFPYLAHAALEPMDGVIELRDDG
AEIWSGIQIPTIAEPVIAGTLGIDPATLTVNTMYTGGSFGRRSTPVSHFEKELAEVAAKA
GPGAYKLLWTREDDMTGGYYRPLTVHHLRAGLDAAGNITGWLNTIANQSIVAGTPFEPMV
MPEGMDPTAIEGSRDMAYDWPANRVSWAQMKNPVPVLWWRSVGHTHTAYATETFLDQALL
AGGKDTVQGRLDLLKSDRPRDRAVLERVAEMANWSGPGTGDRRMGVALHRSFGSYVAQIA
EVEDRGGLPHVTRVWCAVDCGVAVTPDVVRAQMEGGIGYGLGTTLFDEITMAEGGLVQQR
NYDSYRMLALPEMPQIEVSIIASSESPTGVGEPGTPPIAPAVSNAWRALTGAMPYRLPYR
ANSV
>A0A0S4X0K7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MRIRNLEALAGGGVHDPAAPACADASVATLDRRSFLKLTALAGGGFALGVAPMLAGAQDA
AAKPPSPPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAG
DPYKDPLFGIQLTGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSACRTANGVVI
AGSRRATYGELAQAAMALPVPRQVALKNPSQFRIVGKPTPRLDARAKLDASLKFGIDTRL
PDMKVAVVARPPRFGGKVAKYDAAAAKAVKGVVDVVPIQTDRGGTGVAVIADGYWPAKQG
RDALQATWDDAGSRVSSAALMREYKTLADQPGTVAKAADVGAIQSAAKRIRADYEFPYLA
HAPMEPLNCTIDLQSAGGKVSGAKVWVGTQFQTVDQGALAKALGIAPEKVELNTMMAGGG
FGRRAVPTSDYLVEAANVAKAYAAAGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKGTPFESYMLKNGVDATMTEGVIENDYGFPMQVSVHHPDVDVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPVAYRLARFTDKEHERHRQALRLAVDKSGY
GKRKLPKGQAWGVAVHASFESVVAYVVEVSIDQGKPRVHRVTAGVHANRVINPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGAARNSNFPDFPPVRMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDTV
>A0A221V2A2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arenibacter algicola|TrEMBL
MSTSSITFNRRAFIRTSSLASGGLLIGFNLFTACKPKVQPPVDISQLNFNDFNAFIKIAD
NGAVTIFSPNPEIGQGVKTAMPMLIAEELDVAWKNVYVQQGILDTENYTRQLAGGSQSIR
LGWEPLRQTGATARQMLVNAAAAKWGVDPSECTTSEGVITNAKGETLGYGDVVREAAALE
VPENVTLKEPKDFKVIGTDAPNVDIDKIITGKPLFGLDYKVEGMVYASVLRPPAFGKILD
SYDDTKAKAMPGVLDVIRIGEKAKELSKEGIGNWTVTLGKSDKVVVIAKTTWEALKAKEA
ISATWVDDSSLESTEFQDKQLLGLLDGKEFKTLRKDGDINKAFSQADKILERTYESPFLP
HNCMEPMNFFANITDEKIHLVGPVQTPEFAATAVAGMLGRDVKDVHLEMTRMGGGFGRRL
YGDFVYEVAEIADAIKKPVKLVFSREDDMTAGTYRPAIKYRIKASIKDGQVTGYQLKEAA
IGGNMYGLIPNFFPAGAIENYQVDVANYQSNITTGAWRAPYTNFLAFAEQSFFDELAETM
EVDRIQLRLDLLEKVKGTTDERIEYSPERMQNVIKVAVDKSGWGKKEEGIFQGFAAYYCH
NSHVAEVADVEIENGMPVVKKVTCVVDCGIVVNPLGAKNQIEGGVIDGVGHAMYGDLTFL
DGQPQSQNYDKYRLIRMGEIPVVESHLIQNDLAPTGLGEPTLPPAGAAVANALKAATGNR
FTQQPFSKFPELMQVPTKAIIG
>A0A411ZA10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Altererythrobacter insulae|TrEMBL
MPRMTVNERPLEFDMDPDTPLLWALRDAANLTGTKYGCGNGDCGSCMVIVDGAALRSCLV
TIAEAEGRFITTIEGLSRDRSHPVQQALVAEQAIQCGFCTPGIAMAAAALLERNADPSES
EIKAEIPNLCRCGVYPRLVSAIQRAGRVVRRLETIDAAPAPGISSADASREVPAIRPPSG
SDEPEG
>A0A7W9Z3D3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. MP7CTX1|TrEMBL
MSERTTNDGLRNDGIRLSRRRFLQVLAAGAGVLMVGISAADAADAPVPLGLLGNTFYDLG
AFVRIDSDGNVLIGARDPETGTGVATSLPRIIADELDADWSRVRVVPLGLGVADNNGQPR
WTYGRQIGGTGSSIPAAWADLRQVGALARWLLLQAAAQRLGAPANRLRCESGAVIAPDGR
RLDFGSLVEDASKIALPNNAPPPKSADHFQLIGKPAGDVDARAIVTGQMQFASDQQSGDA
LVAVLMHCPWPDGTLEHLDSSDTMAVKGVVKVVQLKPEPGQPWGSTVIAPAVAVLAEDPW
AALQGLHSLKLTWKPGASNSESSASLEQQASALLISTTDPSARVRNDGDVDVASKKAARR
LQATYFQPWLAHATAEPMNCVVRLDKDKASVVVPTQSPRDAWAVVQRLTGLGPAQIEISV
PRVGGGYGRRLDHDYVAEAVMLAQASGKPVRLLWTNEQDLDHDYYRSGSVHQLGAVLDRK
RQLLGWTQRMASASALTHRGVPDNRLWTSEVDADQLPAALVPNYRSDWYALNSAIPRGPA
RGMPHLSNAFAVESFIDEIAHSMKEDPLDTHLRLLGDPRQVALSAGSTLDTGRLLNVLKL
VADRIEWKNWLHSVNGLGIACWHVNGAYVAHAIEVAMQGQKLIIQRVVCAVDVGRVINPM
GLEGQVAGATLDALSTALNLAITFNDGQIQQHNLKDYPLASMAQLPDAVEVIIVPADDVP
PTGASFLAMPTAAPALANAVFRATAVRVRRLPLMKELLRLL
>A0A840YTE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas xinjiangensis|TrEMBL
MAYSLWVNGKTHHVDEDGQTPLLWVLRDALKLTGTKYGCGVAQCGACTVHIDGQPVRSCS
FPLEAASAAQIVTIEGCDGAEANAIRNAWVTRDVPQCGFCQSGQIMSAVALLRATPAPSD
AEIDLAMSGNICRCGTYNRIRAAIHDAAGQVRSTQS
>A0A7U3Z1S6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia sp. AS13|TrEMBL
MITLTVNDQPLTFEGDTHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAVGKKITTIEAIGETPAGKAVQEAWVNLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMGGNVCRCATYVRIRAAIHQAAKALD
>A0A679K2W3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium bullatum|TrEMBL
MVKLTVNGRPHAVEAEPETPLLFVLRDTLGLSGTKYGCGIGQCGACTVLLDGQATRSCQI
PLESVGTQSITTIEAIEQDPVGAKVVAAWIGIEVPQCGYCQSGQVMAATGLLKGTPKPTE
DDIASAMTNLCRCGTYNAIAAAVRQAAA
>A0A679K665|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium bullatum|TrEMBL
MLKVRQTKSEAAAPRPSRRAFLGGAGVAAGALVIGFTLDPAKQVRAAAGPDLSSAPAQPN
AFVRIAADDTVTVLIKHLDMGQGNTTGLATILADELDADWSRVRVAFAPADAKLYNNLLM
GPIQGTGGSTAVANSWFQLRKAGAAARAMLVSAAAEKWSVPASEITVSNGTVRHLASKRE
ERFGALAEAAAAIPVPEQPKLKDPSQWVHIGKKLPRLDSVAKTNGTAIYAMDIRRPGQVT
AVVAHAPRFGGTVSTVDDKAARAVSGVIDVVTIPTGVAVIAKDTWSAMKGRDALSVTWDE
RTAEKRSSDAILAEYRETAKRPGIVASEKGDPAAAIAGSAKVIEAEFTFPYLAHAAMEPL
NATIERAADGSYDIYAGLQFQTIEQAVAAATLGVTADKVRLHTQWAGGSFGRRATPTADY
IAEAASIMKATGGKAPVHLVWTREDDMAGGYYRPMVLHTLKAGIDAKGAVTGWQHRMVGK
SIMIGSPFEAMLVKNGVDSTSIEGASDTPYALPAYRFEVHNAREGVPVLWWRSVGHTHTA
QAMEVFIDELAHAAGADPLAYRLGMLTGAPRLSGVLKLAAEKADWAKRSGGKGQGLGISA
HESFGSYVAMVADITADGSHVKVNRIVAAVDVGVAVNPDVIRAQVEGSVGFALSSVLRNK
ITLTDGVVQEKNFDAYEPTRMSEMPVVEVHIVASDAAPTGIGEPGVPVIAPAISNAIFAA
TGQRLRSLPLDLSGLKGV
>F6ASW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Delftia sp. (strain Cs1-4)|TrEMBL
MPQRPSNERGRTAGSAISLRRRHLLQSAAALLVAPAAGSLLIPLAQAAPAGAGAAAATAS
SIGDWVWIEPSGQVVIGVSQCEVGQGIYTGLPQVLADELDADWASVTVRFVTGRDAYRND
AGEMPFQQFVGASMSMNYFYERMRLAGAQARDVLLRAGAARLGVRASQCSTRAGRVLHSA
TGRSVGYGEIVADASRLSIAARPRMKSASEQGLIGRNLRRVDTPAKVDGSAVFGIDVEVP
GMLIGAVRMAPSVTGRIVRIRNEAEVRARPGVHAVVRTTQWPDPEPSTVVVVADSYWIAK
QAADALDIEFDAGAAAGVDSERIHAQFVAGLSNDKAVVARSLGKPREMLAAGKPITADYH
SPYITHATMEPLAATVHVRDGEVETWGPYQGQDFLRGELGKACGVPADKVIVHTTFLGGS
FGRKYMPDFALHAAAASKAVGRPVKVIRSREDDIRHSYYRPGASGRLSAVLGADGLPAAL
HARISGQSLYGAINPKKMADAGGWDETMVESIYDLIYGVPNLLVDAVDVQQPIPLSYLRS
VGTTSSVFFLESFISELAHTAGVDDYQYRRRLLAGQPLALGVLDAAAKAARWEQPAPAGL
HRAMTFNVYTGRGESFQTFVALVMELRVVEGRVRLERAICAIDAGRVVNPGLVKANVEGG
IGFALTNTFKSRLRFDKGVVQQSNFHDYPLLQLSEMPRVEVVLVESDRPPQGCGEVALGP
TAPAVATALFHATGRRFRSMPLPQDIAST
>I1XFR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylophaga nitratireducenticrescens|TrEMBL
MKLSVNGESHEVNLPEDMPILWTLRDVLGMTGTKFGCGKALCGACTVMLDGQPIRSCSTP
ISAAQGKQITTVEAVSKDKVGQVIQQAWVELGVPQCGYCQSGQVVSATALLRDNPNPSDA
DIDNAMSGNICRCGTYNRIRDAIKLAATNNGGVQ
>D8NB00|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum CMR15|TrEMBL
MNADATAPRRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQAGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVRVERAPIERIYGNVVSVVDSAL
PVHPDDAGKAWARALHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
RAWQVPAAQVSVHDGRLIGPGGRQAGFGEMAAPARDIAPPANVTLKPASQYRLVGQPAPR
SDVAGKTDGSARFAIDARPPGLLYAAVAMCPVFGGRLTAFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLEPVWDSGPHATLDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVNGATVIEAEYSVPYLAHAALEPINCTAQVTQGHVQLWAPTQVATLAQLV
AARAAGVSREQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAVARLKARIERGRVTALASRSAGQSILAGELGRLFGAPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEAAAAAGLDPLAMRRDLLAAHP
RERAVLDTAARAAGWGQPLAPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGMVVNPGIVAQQVESGVIFGLGAALHGQIQIKDGQVVQSNYPDYPVLGMADTPV
IETHLVPSTAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A7X5XVJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas trueperi|TrEMBL
MSDPKPAARGFRMTRRRMVLGGGLTGGALVIGYAATHPMEVAAMVLSGGGHDPEPSAFGA
YIRIAADGMVTIVNKQQELGQGIHAALAAMIAEELDADWSRVRVVSAEVNFRAYGVQLTY
GSFSVSTQWDAMRRAGAAARAMFVAAAARRWRVPRASIGVRDGIVSHPATGRSAPFAALL
ADADRETPPQQPRLKQPAEYRLIGTDRVRRKDAVPKSTGAQVYTQDVQRSGMLFAVLARS
PRFGGRPARFDDRAARQVAGVVDVFATPAGVAVVAENSFAALRARAALRTEWDDRQAERR
STPEIVEEYHSIALGRSTLKPDRFLQRGDADRRFGEGQFEAAFDFPYLAHAPMETLDCVA
QVDGWQVRIASGSHLATGELVNAAIATPTIPGKVELEVLPAGGSFGRRGAAMGDYVAECV
HIARRLQGRPVKLFWSREDDLTGGYYRPMAHHRLWIESGADGLPTAWRHHIVAQQLLPFG
ANSPNYEGVKNSPYLAAVSTLDCKIFTPTSPVTATFWRSVGHSHGTMVMEHVVDQLARRA
ARDPADYRRALYRRAGATRHLAVLDAVCREAGWGTSIDAGWARGLAVQDYAGTVVGQVAE
VRLEAGRPVVRRVVAAVDCGIAISPDQIAAQMEGGIGFGLSAALYGAITLKDGIVEQRNF
DGYRVARIDDMPRVETHILRSTAPPTGMGEPGVPPIAPAIANAILALTGRPTRRLPFVGT
DA
>A0A375ENQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLEMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A375BXJ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTKFQLNGQPRDVDVPDEMPLLWALRDELGMTGTKFGCGMALCGACTVHVDGTAIRACVT
PVSAVTGRSVATIEGMEADRVGQAVQQAWIQHNVAQCGYCQAGQIMAAVSLLKTTPAPSE
RQIDEAMSGNICRCGTYPRIRAAIRQAASRLAQGGK
>A0A375IGA7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLESVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAAQQLGVDAAALAAENGVFRVPGTQAGIRYAALV
AGAHVELPLAEDVPTKPVDAYRIVGHAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLAIDRDSVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
QPVLPLPALDDPEPALRANPATRRELLSEGELPADGAGTVLRRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGVVPNAPRTLEMGDRTAVPPYAYTARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDQRAADLLRAVAEAAGWQRGAAGTRGVPDADGQLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRITIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVVLMPRQSEPPLGAGESA
SLPGAPALANALFDALGVRLRRPPFVPETVLAAMASMTAAASTKG
>A0A8E0GBM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia thailandensis MSMB43|TrEMBL
MLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCVLPLAA
VAGKRVTTVEGLASKPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTDADIDA
AMNGNICRCATYTRIRAAIHEAAATLKA
>A0A6V6ZGE5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF57|TrEMBL
MASVGKILRRTFLIGSAAIVGGVAFGAYYVTRPAANPLKPAKGETALSPFILIDQQGVTL
FAPRAEMGQGVMTTWAALIAEELDVEMDDIRVLHGPAAAAYYNSALVGEGLPNKGYDISD
FQHNLGEALGVLGKTLSLQVTGGSTSMKDGFERMREAGATARETLKQAAADRLGVDRAQL
KTEAGVVIAPDGTRIPYTELAEAAGRIDPPHAELRDPSDWRLLGQNLPRVDIVGKTTGTA
EYGIDVRPEGLKFASVRMNPKLGGAMNSFNASAAQSMPGVEMVVDLGNGVAVVATNTWLA
IQAVEAIDVDWADAPYPSETDDLFATIAQAFEDAPNSTMRDDGDVDVLPDGATEITAEYR
VPYLAHSTMEPMNATALFTGTKLDLWCGNQAPTLLQIRAANTANLDKEAVEVHTTYLGGG
FGRRGELDFAEIATKVAMAMPNVPVQTTWSREEDMRHDFYRPGALARMRGAVKDGAAVLI
DGKVAAQSCTQQAVERYTGMPGGGPDKVLVEGLFNQPYAVPNYRISGHIADLDVPVGFWR
SVGNSHNGFFHETFMDEMAHAAGRDPLEFRLELAKAEFAPAAGVLQAVKEMSGWTGQTPD
GVGRGVAMTYSFGTPVAQVIEVVDEDGTIRIAKAWIACDVGLALDPGTVKAQMVGGMIYG
LSAAVTGEITFSDGEVEQYNFPDYDALRMHNAPLTEVRVLETNPRLGGVGEPGTPPSLPA
LGNALFDLTGERARTLPLINQFNLLV
>A0A4P8HSR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MTAPGSPARRRFLGQSAGLVVAFHIPFAAPAQDAQSPEVNAWVVVKPDDTIVIRIARSEM
GQGTLTGLAQLVAEELDADWSKVTTEYPTPGTNLARKRVWGSFSTGGSNGVRGSHEYMRK
GGAAARAMLVQAAATQWGVPASECGAANSVITHVPSGRTVTYGKVADAAGKLEAPKEVPV
KDPKDWKIAGKRLARLDTVDKTTGKQVYGMDLAMPGMLNAAIKDCPVFGGKVKSFNADAI
KDRPGVKKVLQVGDSAVAVVADTWWRAKTALDALPIEWDKGPNANLSSKDVAATLKAGLD
APEAAVGNENGDAKAALAGAARRIEAVYSYPHQNHATMETMNATARWTPERCEVWTPTQN
GEAALAAASEAAGLPQERCDVYKIHLGGGFGRRGAVHDWVRQTVQIAKEMPGTPIKLIWT
REEDMLHGRYHPVTQCKLTAGLDKAGNLTALHMRISGQSIVAALFPGNVKNGKDGAVFQG
LNAPGTDASIGYTVPNLLVDHAMRNPPVPPGFWRGVNLNQNAIYLECFIDEIAHATKQDP
LALRRKLMKDSPKHLAVLNAVAERIGWQKKPKKGIYRGLAQTMGFGSYVAACAEVSVDKE
GKLKIHRIVAATDPGHAVNPQQIEAQVEGSFVYGLSAALYGECTVKDGQMEQANFDSYPV
MKMDEMPAVETIIVPSGGFWGGVGEPTIAVAAPAVLNAIFAATGKRIRDLPLKNHSLKKA
>A0A1L5P9V1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli 8C-3|TrEMBL
MPRFLSRRGFLITGAALGGTALVAAVGGAGYLASVDVDGLHGHLDGDRAALNAFLIIQDD
GRVVVNVPRTEMGQGIHTGLAMVVAEELDIPFDDRITVEFPTEAHPAYSVWFNMLQIRPE
EASGPVVWVGRRVLGQLGFIATGASGSTMGMWHPMRVAGASARHMLLAAAAARLGVPAAD
LATGDGFVRHEASGQRLSYGELSRSAALLPPPDRPALKPASEWRIIGRSQPRVDLPAKAR
GEPVFGMDVALPDMVHAAIRHAPVFGAKVAGVVNEDEVRAVAGVRDVAVIDGQKVAVVAD
SWWQAEQAAWLLDIEWTKTAADGVSSSEMSARLRSALGSPTPYEHIDDGDADFVIANADA
SAVVEADYTVPFLPHACMEPINATVLVRDDLIAEVWVSSQSPMAVRQGVARGAGLAGVET
TSVTCNITMNGGAFGRRSDQDVVAEAAFLAARHRGRPVKLIWSREEDISRGLFRSHAAAR
LRAALGPDGLPVAYDALVATQSVIESVASRNLPVNPGPDGDRISVEGLDKLHYAIPNRRI
RSQHVPSHMPIHFWRSNGFSFNTFFTESFIDECALAAKADPLAYRRALLRGSPRHLAVLN
RAAELAKWGTPMAPGRGRGIAIEECYRSVVAQVAEVTVAADGEVRVDRVFCAIDAGLVIN
PDAVIAQMEGGISFGVTTALMSAISLDAGAVVESNFHDFPMQRLANAPAIEVAIVDSGLP
PGGAGEPGIVPVAGAIANAIHAATGRRIRSLPLAVTETVDERRTRTVLPPVAT
>A0A2R8BGC6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ascidiaceihabitans donghaensis|TrEMBL
MQLTVNGTNHDVDVEDDMPLLWVLRDEIGITGVKYGCGVAQCGACTVHIDGEAVKSCQIS
AADVESPITTIEGLGNPDALHSVQEAWIEHQVAQCGYCQSGQIMAAAAFLAQTPNPTDAD
IDDAMSSNLCRCGTYPRIRAAVKSAAAKMERA
>A0A4V6Z306|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium thalpophilum|TrEMBL
MAKYSIQVNGKKHEVDVLDDMPLLWVLRDIMNLKGTKFGCGKALCGACTVHLNDTAIRSC
SFPISAVGEGKITTIEGLSTDGDHPLQEAWEKYVVPQCGYCQTGQIMNAAALLKKNAKPS
EQEIEEAMKGNLCRCGTYNRIKAAILDAAGTPVTTG
>A0A518DDB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pirellulimonas nuda|TrEMBL
MKVTFQLNGELQSVEAEPDRPLLWVLREDLGLTGTKFGCGRALCGACTLHVDDEATRACA
FPIKFAEGRRITTIEYLENDPRGKAVIDAWIEKDVVQCGWCQPGQCMSAAALLKEIPNPD
DEDINAAMAGNLCRCGTYGRIREAIKVAAAAVGKEVVL
>A0A518DDF1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pirellulimonas nuda|TrEMBL
MSIERRFQAAFAQIMAGPQQRIPPTPAVTVDLVPHGVSRRSFLQQAIASGSGLALAVSFG
ESSIVHAQTAAASSEAAGDFAPNAFVKITAEGVVTIIAMHDEMGQGIHTGLAIAVCEELE
IDPAEVSVVHAPAHPDYSHVDYGVQMTGGSSSIYSARDPMRKAGATAREMLIGAAAERWS
VDRRLCSAVEGHIVNNVTGKKLTYGELAADAAKLKVPEEVRLKDPKDFTRIGRHTHRVDS
ATKVRGTALFSFDKRVDGMLTAMVERCPYFGGTLVNFDATKATQVAGVKAVIQVDSGIAV
VADGYWSSLKGRRALKIEWDPGAAAMLDSEKLWMQYREMARQEARVVEREGNVEQSLGDN
RTFHATYEVPFQAHAPMEPLSCLVTLRDDGGADLVTGSQMLGVDRLQVAGRLGVPVESVR
IENCYLGGGFGRRANPASDFLVEAVDVALAAKREGNSAPIKTVWSREDDIRGGWYRPMYV
NAVSATFKNGRIDAWRHRIVGQSTLIGTTFEPMMVVDGLDPTCTEGATRLPYAIPNKQIE
LQTVRLPAPVQWWRSVGHSNTAFAKESFFDECAENLKRDPLELRQELLRDQPRLLRVLNT
VAEKAGWGQPSPEGIGRGISVHESFEGFAAHVVEASVEGGVPKIHRIVVAIDCGPVVNPD
QVVAQMESGAHFALSSILNGEITFKDGLVEQSNFDDFLVVRMHEAPMIEVHIVDSDDKMG
GAGEVGVPGVASAVCSAIYDACGKRIRRLPIGTQLEQ
>A0A7W6XIT5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR48|TrEMBL
MPTLTINGRNLSVDAANDTPLLWAIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
MLSDVAGKKITTIEGLSAKGDHPLQKAWVAEQVPQCGYCQSGQIMQAASLLSKNPNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAASEMRTASATSTERRPT
>A0A7W9EX22|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas aerophila|TrEMBL
MATGRITRRGLLVGGGAGAGLLVAWALWPRRYAETLVTGPGEHLFGAWLKIGEDGRVIVA
VPQVEHGQGVFTALPQIVADELGADWRTVAVEPTPASPLYANPLALDELWGGAFDQVPAP
VRGEWARRAALMLTGGSTSVRQFEDDLRVAGATARALLLKAAARRWDVDWTQCRTQAGFV
VTGRNRLRFAELAAAAASEEAPDPLPQGVQGAGALAGKPLPRLDAPAKVDGSANFAADIR
LADMVHVAVRAGPQGDTRLVHADRAAADRVAGVVAVVENRRWVAAAATTSWAAQRGLDAL
APRFESRGALADDAGIEGALRRALADKGHRVASAGSLGQLLSGGGVVEAEFQVAPALHAA
IETPSATASFHDGRLELWLQTQAPTIARAAAARAAGLAEHAVTVHPMMIGGSFGAALDHE
VAEQAAVLAMTLKRPISLIWSRGESLIHDRCRTAVIARMRGRLAANGTPVAWNAQIAAPA
TGRAMAQRMLPASVADLADLGRGGDAQAVGGAVPSYRIANWAVDHHPADLPLQSGYLRGG
ADGYTAFFNECFMDELAATAGTEPVSFRIGMLGGDPRLARCLSTAASLGGWDGGVAGSGQ
GIACHRLRGSAVAVMAEARIERGQPVVERLVAAVDCGRVVNPDLVRQQIEGGLVFGLAQA
LGATTGYERGLARVRGFDTLHLPRLADTPDITVELIRSDEAPGGVSEIGIPAVAPALAGA
LHSLTGKRLRSLPLVIPA
>A0A0P7YQ05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Porphyrobacter sp. HL-46|TrEMBL
GGLVFGMGIALGNPVKLRAGIPESLDYAGLGLPVLADCPEMRIEFLPSEAPPADPGELGA
VVAPPAIANALFSATGLRLRRLPLLSDGI
>A0A841HE44|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MSTAEKDIFPQVDRRDLLKGTAALTVAFWLPAGKALANGGTGAVFEPNAFIRIGADGIVT
VVSKHIEMGQGAYTGLATIVAEELDADWTKVRVEGAPADAKRYNNLNFGPMQGTGGSSSI
SNSFDQLRNAGAAARAMLVAAAAQKWSVPASEVSVVNGVVAHAKSNRSAGFGELAADAAK
LPVPADAKPKDPSKYTLIGKNAARVDSRDKSTGKALFTQDVQLPGMLTAAVVHPPRFGAR
VKSFDATKAKAVKGVKSVVAFETPVRSGIAVLATDFWTAKKARDLVTVEWDESAAYRGST
TELYKEYRELAKKPGASAKKEGDPDAAFASAAEVLEATYEFPYLAHASMEPLNCVVRIGK
QDCEVWNGEQFQTVDQLAVAKTVGLPPASVNIHMLYAGGSFGRRANPQADYVVEAAAIAK
AAGVDVPVKMVWTREEDTRAGYYRPLYVHTLKAGLDKAGKIVAWQHRIVGQSIVAGTPFG
GPGPIDATSVEGASNLPYAIPNLAVELHTTKNGVPVQWWRSVGSTHTAFSTECFLDDIAR
HTKQDPYALRKSLLTDKHPRHNAVLDLVAQKSGWSQARPKDEVWGLALHESFNSVVAQVV
QLKRTSNGLKLAKVICAVDCGLAVNPNIVAMQMEGGIGYGLAAALTGAVTLKDGVVEQSN
FDDYPVLRMNQMPAIDVHILPSTAKPTGVGEPGTPPIAPALANALALANGKPVRVLPLSA
EGITLA
>A0A380B2F6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MITLTVNDQPLTFDGDPHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAEGKKITTIEAIGETPTGKAVQAAWVNLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMSGNVCRCATYVRIRAAIHQAAKALD
>A0A3G7JDK3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDAFAEEKKFGADGMPHGWVDDPK
VYVSIAADGSVTVLCNRSEMGQGVRTSLSMVVADELEADWALVKVKQAPGDEALFGNQDT
DGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPLAECRAQLHKVIHQPSGRELGYGAL
AAAASALAVPARDSLRLKQPSEFRYIGKEGTRAIDGADIVNGQAVYGADVHFDGMLFATV
ARPRVYGGKVKSFDGSAALKVPGVVKVLQIDSRPLPSEFQPLGGVAVIASNTWAAIKGRE
ALKIEWDDGVNAGYDSIAYRKELEAAALKPGKVVRSTGNIDEAMSSADSSLEASYYLPHL
AQAPMEPMVAVARFKDGQCEAWAPSQAPQVTRERIAERLGIPFDKVTVNITLLGGGFGRK
SKPDFVLEAAILAKEVPGKAVRVQWTREDDIHNSYFHTVSAEYLKASLNKDGMPSGWLHR
TVAPSITALFAPGMNHEAAFELGMGFTNLAYAIPNVRLENPEAAAHTRVGWYRSVSNIPH
GFAIQSFVDELAHKAGQDPLKYQLKLLGPDRRIDPRTLSEEWNYGESPERYPIDTARMRG
VLETAAKAAGWGRSLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDCGP
QINPERIRSQFEGACVMGLGNAVVGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHLVT
PPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQQASKA
>A0A1Y6KB47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCIT
AISDVVGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNQNPKPSHD
QIRDAMSGNICRCGCYQRIENAVHLASTGV
>A0A388RE60|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MTATTLQPVEQADPATPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
IFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLSQVRMVLGHTEATPNQGPTI
ASASIQISAIPLRRAAAQARAWLLARAAQQLGVAPDQLEAQDGEFRVRGSDAPIGYGTLV
QGEHVALPLADDVPIKPVESYRIVGRSAGRVDIPAKARGVLTFVHDVRVPGMLHGRVVRP
PYAGRDSGDFVGNSLLAVDRESVRDVPGLVDVVVQGDFVGVVAEREEYAVLAARKLRVQW
KAVPPMPSLADPEPALRANPATRRELLNDGEMPPAGAGKTLDRHYVWPYQMHGSIGPSCA
VADWHEDGLTVWSGTQNPHVLRIDLARLCGLGEDSIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGELLGYDFTSRYPSNDAPTL
ALVLAGIVPNAPRTLEMGDRTAVPPYAYRARRIGCDDTPAIVRASWLRGVSALPNSFAHE
CVIDELAAEAGMDPIDFRLRHLPDPRAAELLHAVADAADWQRGAHGSRGSAGADGMLRGR
GVAYARYIHSRFPGFGAAWAAWVVDVAVEAATGRITVQKLVVGQDTGMMVNPDGVRHQIH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVVLMPRQEEPPMGAGESA
SLPGAPAIANALFDAIGVRLRRPPFVPETVLAALRS
>A0A7W5EK89|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteibacter sp. Sphag1AF|TrEMBL
MAQQGPNAPVPVPTADAHQPAPRPVREGIDLVVNDKRYRHTGDASMPLLWYLRDELRLTG
AKYGCDSGECGFCTVLVDGKAVQACATKMEKLAGKRVTTVEGLADGQGNLHPVQQAWITE
DATLCGYCQPGQLMAAVDLLARQKNPSDADIDKITNLCRCGSYGPIRKAIKRAAAAMKDA
KA
>A0A0P7VES6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium HLUCCO07|TrEMBL
MQIEVNGLAHELDVEEDMPLLWVLRDELGIKGVKYGCGIAQCGACTVHIDGEAVKSCQVF
AGDVWGEVTTIEADADELPVLRAVQSAWIEHQVAQCGYCQSGQIMSAASLLSENRNPSDT
EIDEAMRSNLCRCGTYPRIREAVKSAGERVREG
>A0A1V0RSH4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus|TrEMBL
MLLTVNGKSHDVDLPSDMPLLWVLRDGLNVTSVKYGCGIALCGACTVHIGGDAVRSCQVS
LGDVWADVTTIEGLGRPGALHAVQAAWITHQVAQCGYCQSGQIMQAADLLARNPEPSDDD
IDAAMSGNLCRCGTYPRIRAAVHAAASAMREV
>A0A1W7M6S7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MARLTVNNQPMEFRLEPDTPLLWALRDAANLTGTKYGCGTGECGACMVIVDGQAMPSCTL
SLGEAEGRSVTTIEGLAPDRNHPVQQALVAEQAIQCGFCTPGLVMAAAALLAHNGDPTEQ
DIAAAITNICRCGVYPRLVRAIQRAGRALRHAETLPPLPVPATATAPGL
>A0A6J4P4B8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Ramlibacter sp|TrEMBL
MQLTINGRAVEADAEPDMPLLWVLRDVLNMTGTKYGCGVAACGACTVRVDGQPVRSCVTP
ASSVAGKRIVTIEGLGSKAAPHALQAAWIAEQVPQCGYCQSGMLMAAAALLERRPKPTDA
DIDEAITNICRCGTYQRVRAAIKRAAGVKA
>A0A0E0UPP2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium meliloti (strain BL225C)|TrEMBL
MISLTVNGSPHQIDADPATPLLYVLRDELALNGAKYGCGLGQCGSCTVVVDGEAVLSCMV
PIMLLEGREITTIEGLGTIDEPGPLQEAFIELQAAQCGYCIPGMMMSAHALLRRNAQPSE
EEIREALATNLCRCGTHMRILAAIRRAGELMRAASLPATDQGRAG
>A0A0J9EBC6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Rhodobacter lobularis|TrEMBL
MNTSTSRRNFLKGAAATGAVLMVGVTPKGVLAAGHAGLASLTPFVKIDEAGTVTAVLKHF
DMGQGASTGLATLIAEELGISLDEIEIEFAPHNPQVYNNLFFGPVQGTGGSTAIANSFMQ
YRQAGAAAREMIKAAAANAWGVAASELAIVDGVVTGAGQSAPMAEFVAAAADLAVPEDPS
LTDPKDFRLIGNPTTHRKDNAPKITGQAQYAMDVHLDGQVVAVIKRPPKFGATVVSFDAS
AAEGMPGYKGAAALPTGGGVVVYADTTWQAFQAREELTVEWDFTNAETRSSDQIRDDMLA
MVNSEPEFVARADEGTDAAMAGAAQVIEKEFYFPYLAHASMEVLNCTIRPDEDGGVTLFD
GCQVPTLSAGALAQVLQMPMEKVRVETLWAGGSFGRRATSEVDYNVEAGLAFLLDGGQRP
VKLMWSREDDTTGGYYRPAAAHKVRVGLDANGRIVAWQHQLATPSIFKGTFFAATQVVDG
VDRSSVEGVPDTLYDIPKMTMGVSDFQSPITVAWLRSVGHNHTGYVMETMMDLAAEAAGV
DPLEYRLSYLSGEGEERARMREAFQLAADTAGWGTPLPDGHARGIAGMFCFNTAVAQVAE
VSKDEDGYVQIEKFSAGVDVGLAVNPDVVEAQVQGGIGFALGFIMRDGIGFDEGEVIQSN
FHDYEPLRVWDIKDIEVAIVPSAAPPSGIAEPPVPPAGPALANAIAALGTRVTMLPMAEN
GVDFV
>A0A6S7B9T1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ultramafica|TrEMBL
MSEIVNLSRRRVLKGTFAGGVVLGLHIGGAGPALAASVLSSANGAQGGFAPNVYVSVAPS
GEIILVVHRSEMGTGIRTSLAMILADELDADWNSVKVMQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGSARQMLVAAAAAQWRVAPATCHTEPGHVLHAPSGRRLAYGALAAAAALQPV
PGRDTLHLKDKDTWRYIGKSLPIVDLDDIVHGRATYGIDVVLPRMTYASIERSAVYGATL
RSVDSTETMKVPGVLHVVRIPAAPLPAGFKPVGGIAVVATNTWAALQGRRKLKLAWDLGP
NASYDSQAYRKTLEDTARQPGKPVRNNGDTEAALKGAAHHVSADYYVPHLAHAAMEPLAA
TASYANGAVQVWTATQNPQQARTTVAQVLGLQEQAVTINVTLLGGGFGRKSKPDYVAEAA
FLSREVGAPVKLTWTREDDVRNDYYHAVSAQHMEGGLDAQGRTVAWLHRTVFPSITSTFK
ADVRYGAAGELGQGVTDMPYDVANVRCENGPASAHTRIGWYRSVYNIPHGFAVGSFVDEL
AAAARQDPVQHLLAMLGSPRHVDLHALGVDYPNYGASIDEYPIDTARYAAVVRAVAARSG
WSTALPARHGRGIAVHRSFLSYVAAVAQVQVAADGSVRVTRVDLAVDCGRIVNPDRVIAQ
FEGAVVMALGNTLYSELTFVNGAAEQSNFTDYRVARIDSVPQTHVYIVPSNAPPGGVGEP
GVPPTSAAICNAIFNATGRRIRALPVDTALLKRT
>A0A6S7C952|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ultramafica|TrEMBL
MSRGLLDAQNGAASSKGSAGGVSRRAFLKFGVTVGAAAGGGLLLGFSMPAASQDQKAGKS
AIGGDAVEAPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVPLDA
VTLDHAPPSEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARIMLINAAAQQWQVDPA
SCRAQAGQVIHAPSKRSIGYGQLAEAAAKLPAPQNVPLKDPKDFKLIGTAVKRLDSPEKV
DGTALFGLDVRVPGMVYAAIANCPVFGGTLASVDDSNAKKIPGVRQVVKLDNAVAVIGDH
TWAAKRGVQALDIKWNEGAGANLSMKQIVDDLTNASQRNGAVARKEGDVGNAFSHAKSRV
DAVYQQPFLAHATMEPVNCTVHVRADGCEIWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LLGGGFGRRLEFDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLDANG
KPIAWQHRIVGSSILARFAPPAFKNGLDPDAVEVASDLPYDLPNQLVDYVRQEPHAVPTA
FWRGVGPTRGTFVVESFIDELAIEAKVDPVKYRQDLLGKTPRALNVLNTAAQAAGWGSAL
PKGQGRGVSVMHAFGSFFAIVVDVAVDQGEVAVKRVVCAVDCGMVVNPNTIEAQVQGGII
FGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIDVHIAKSSEAPGGIGEPGTAALA
PALTNAIYAAIGKRLRQLPVGSQLKTA
>A0A517SN63|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Planctomycetes bacterium SV_7m_r|TrEMBL
MSTSKTNVNDASPMQHSLQQAQRQLNDYAAAVMQSGPGRQANAALAVSQSPATTSRRTFL
AASAAAGSFVLVMNSQNGDAAQVQDSSVATENSFNPDLFVSIAPDGTVSILTHRSEMGTG
IRTTLPRIVADELEANWDDVNVVQAIGDKRLGDQNTDGSNSIRFFFDRMRVAGATTRTML
QQAAAKKWGVAVDQCIAKENHIIDQKSGKKIGYGELVEIAKTLPIPKADSLKFKPKSQWQ
YIGKDAPIIDQDAILTGKAIYGIDARMPNQLYAVVARPPVVGGVVKSVDDKDALSTPGVE
QVLQIPAFKGAPLFQPLGGVAVLAKSTWAAIAGRDSLDIEWDLGENADYDTDAFAKTLAE
AAHQPGKVMRKAGDAPALIEKAAADTNNRVLHADYRSPHLSHAPMEPPCAVADVRTENGQ
IVHCLIDTATQNPQAVQQAVSAALSIPPQEVIVNVTLLGSAFGRKSKPDYCVEAALLSLQ
AQRPVHVTFTREDDLQSDYFHTISHLHLQAAVDENGAPEALLARAAYPTIGSTFVAGADQ
PQAWEMEMGLTDIPYDIPNLQIEGCNAKSHTRIGWLRSVAHIQQNFALGSFIDELAHHAG
IDPYEYLLTTLGADRQIDMKAAGLGNRGASHDNYPYDIGRLKNVVKRAADLSDWKRAGEL
PKGRGMGIACCRSFLGYTGHVVEVEVSREGKLTIHKVWVSLDAGLIVNPDRVKAQIEGAT
VMATTQARYGKISFKKGRSVESNFDSYRMVTMSDCPREIIADVVESDEAPAGVGETPVPS
YAPALCNAIFAATGHRVRDLPLSEFDLSWS
>A0A7W6CHM4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MPIILSVNGQKHSIDNAAADVPLLWVLRDMVGMTGTKFGCGVGLCGACGVLIGGQRFFSC
QTPLRAVIGRDVTTIEGLGEDPHGAALQQAWEEADVVQCGYCQPGQLIAACALLKANPRP
DDAAIDEGMSGNLCRCGTYPRIRKAVKLAAGGGR
>A0A7W6CE09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MSEGGFSRRGVLQGAAAVGAALVVPVARGAAGGALAANAYISVTSLGVELALPKTEMGQG
VITSLSMLVAEELGVALNKVRVSIPDGDAPRFAPITQETGGSTSIREVYKPMRQAAARAR
VGLIEAAARQWGIAPGQCDLVDGMVVAGKRRIAMGDLIAAASLPREAPLRDRLGLIGRPT
RRIDARPKITGALQFGIDFRLPGMKVATLAQCPIYGGTLAGLDEKAALAIPGVVKLVKGR
DVVFVVADHYWAALQGYVAANVQWAPGPKPAEQGAIVADLDAALTRPGHSAKAQGDLNAA
RGREFSATYHQPFLAHAAMEPLACTIHVTEKGCEIWSGSQVPAQARADAAKALGLGEDKV
TFHNFQMGGGFGRRLETDMVLRAVELGRAVPYPVKLVWSREEDVQHDMFRPAYADRIRAT
VDDKGRPIAWEHRIAGSSIMARLMGDGFKGVDGDAIEGAVEMPYAVAAHHVTFQQVESAV
PTSWWRGVGGLRSCFVVESFIDELAHGAGADPLAYRLALMQDARSRAVLARAAKEAGWGR
ALPLGQGMGIAVLKLWGTHIAAVVEAKVEDAQISVPRVTIAVDCGLAINPLGIEAQVESG
VIFGLSAALYGEITMRDGAAQQSNYHDFRILRMNEAPRIATHIIASQADPGGMGEPPCAV
VAPALANAVFAASGQRMRTLPLMA
>A0A1X7AGM2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Parendozoicomonas haliclonae|TrEMBL
MITLTVNGQTRSLDIDADTPLLWVIRDELQLTGTKFGCGAGLCGACTVHLNGSPIRSCIT
PVSAVAGTEITTIEGLGTPDNPHPLQESWVENSVPQCGYCQSGQLMSAAALLATNPQPSD
DDISMAMSGNICRCGTYPRIKAAIHLAADAMANDKDDNQEKTGEASHV
>A0A7W6CPT8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MPALTLNGHPVDLRMDAATPLLWGLRCGANLTGAKYGCGTGECGACMVMVDGQALPSCQI
TLAQAQGRSITTIEGLSNDRSHPLQQAMVAEGAIQCGFCTPGIVMAGAALLAANAEPSAD
DINKAVTNLCRCGVYPRLVRAIQRAGRVMRGLETIAAAPAPGGNTHQRSIP
>A0A509E2K8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassocella blandensis|TrEMBL
MLTLNVNGQVVTIEASSDVSLLWVLREHLGLTGTKYGCGAGMCGACTVHIDGVANFACQI
MAADAANTTITTIEGLSEDGTHPLQLAWIEEQTPQCGYCQSGQIMRAAALIADNPKPTRE
EIIDGMSANICRCGSYPRIVRAIERAVKEDHHG
>A0A2Z4LX39|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda aurantiaca|TrEMBL
MSTNKTLTFSRRAFMRTSSLAGGGMLIGFNLFQACKPKAAPPIDLAQLNYNDFNAFIQIA
DNGAVTIFSPNPEIGQGVKTSMPMIIAEELDVAWKDVYVKQGVLDTENYTRQVAGGSQSI
RQGWDALRQTGATAKQMLVNAAAAKWGVDASELKVSEGVITNAAGETLGYGDVVREAALL
EVPEDVALKEPKDYKIIGKDASNVDIDKIVTGKPLFGLDYKVDGMVYAAVVRPPAFGHKL
ISFDDTEARSMSGVVDIFKIGDKVRGLLEEDPSFSSKISSSDKVVVVANSTWQALKAKEA
IKAEWEEDTTIESTEEHDKILTDLLDGDSFETPRSDGDIKKGFAQADDILERTYESPFLP
HNCMEPMNFFANVTEEKVHLAGPIQTPAWKAGLVAKMLGREEGDIYLEMTRMGGGFGRRL
YGDFVIEAAEISNHIKKPVKVVYSREDDMQTGVYRPAIKYRIKAGIKDGKITAYHLKEAA
INDNMYGLIPNFFPAGAIENYQVDMAKYDSNITTGAWRAPYTNFLAFAEQSFFDELAELM
EVDKIQLRLDLLDKVKPEEDERIQYSPERMKDVIKMAVEKSGWGSKPKNVHQGFVNYYCH
NTHVAEVADVEIENGEPVVKKITCVVDCGIVVNPLGALNQIEGGVIDGVGHSMYGELEFK
DGKPLANNFDRYRLIRMKEAPIVETYFIENEYSPTGLGEPTLPPAGGAVANAFKAATGNR
LYKQPFTKTPELLKVQEKEIIG
>A0A0B6S574|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia plantarii|TrEMBL
MSSGIIEASRAASAADGDAAGISRRRFLQAGFTLGAAAGGGLLLGFAVPASGGATRPSVI
GGDAPDQAPAGLFAPNAFVRVDRSGQVTLVMPKVEMGQGVYTSIPMLIAEELEVPLDSVV
LDHAPADAKHYGDPLLGGGQLTGGSTSIRYAWDPMRRAGATARTLLVAAAAQQWKVDPAS
CSAANGEVLHAPSGRRAGYGSLVDAAAKLPVPANVALKQPEAFTLIGKPVKRLDSPEKVD
GTAQFGLDVRLPGMLYAAIVNSPVFGGTVASVDDSAAKRVPGVRQVVRVDNAVAVVGDHT
WAAKRGAAALVITWHEGDGARVSMDDIVGDLARASERPGAVARNDGDVAKAFGSAGARID
SVYQQPFLAHATMEPVNCTVHVRGDGCEIWVGTQVPGFAVDAAKRVTGFDESRIVLHNHL
LGGGFGRRLETDMIAQALKVGKQVDAPVKVVWTREEDIRHDMYRPYYYDRISAGVDANGK
PVAWQHRIVGSSIMARFAPGAVKNDVDSDAVEVAADLPYEIPNQRVEYVRQEPRHVPTAF
WRGVGPTRSAFVVESFIDELAVHAKADPVAYRRSLLGRTPRARNVLDVVARESGWGQAVP
AGHGRGVSVLHAFGSFFSMIVDVAVADGEVSVERVVCAVDCGMVVNPDTVEAQIQGGIVF
GITAALYGEITIRDGRVEQSNFTDYRMLRINQTPKIDVHIVKSTEAPGGIGEPGTSAIAA
AVANAIHAATGKRLYRLPVGDQLKTA
>A0A0B6S242|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia plantarii|TrEMBL
MTTLNINGVTHSVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGEAARSCVL
PVAAVAGRKITTIEAVGMTPVGAKVQQAWRKLDVVQCGYCQSGQVMAAASLLASNPHPND
ADIDAAMAGNICRCGTYNRIRAAIKLAAREA
>A0A509E843|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MNALSPLSRSDREPVRNLSRRTFLGAASGALLLGVGMRLSPAVAQTRAEGPAAVAPKPGT
RVAAFLEIRPDNSVRLLSPFVEGGQGINTGLAQTIGEELDLDPGRFAVECAPPGPDYAVV
NGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAAKLSVPQASLTTEDGRVIHAASGRA
LGYGELAAAALALQPRDDVPLKDPARFRWIGKPVQRLDMRDKSTGRAVYSIDIRLDGMLQ
AAVQHAPHLGTEPEAITNEAEIRAMPGVHGVHRLPGAVAVVADTWWRARKGAEALAVTWS
KPAPEGVDTVSAGFSSAAMLAALKGSTAPGIPAEQEGDTAAAFAKAPRIVEAEYDAPYLA
HAQLEPPSAVAHFAADGSLDLWLPNQMPELFQQVAAKVAGVQPDSVRIHSPMLGGFFGRH
FFYGPANPFPQAILLAKATGRPVRVLWSREEEFGMDAVRPLSFARFKAALGADGLPMALQ
TTAVGEGPIGRWFGALFKSPVDSSVVEGLDKKPYAIPNRRLDYVKVPHPVTIAFWRSVGH
SMNDYFYESFLDEVAQAGGRDPYDLRMALLKDSARHRTLLKTVADLAGGWRRGPFTAEDG
TKRARGVSMASPFGSETATIAEVSLKDGEARVHDLWIAIDPGSVVNPAIVKRQVESAAAL
GLSSTLLEQVVYEGGQRQAKNFDAYPILDRERMPRVHVAIVESGAPMGGIGEPGLPGVPP
AVVNAVAALTGQRLRSLPLSKARLSGA
>A0A6S6SJS9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thiotrichaceae bacterium|TrEMBL
MSTTITLNGKDTAIDASPDTPLLWVLRDHLALTGTKYGCGMAQCGSCTVHLDGVAIRSCV
TPLSAVASKKVTTIEGVATKEAKAVQAAWDKLDVVQCGYCQSGQIMSAAALLSTNLNPED
SDIDAAMSGNICRCATYVRIRAAIKEAAAELGAQS
>A0A840A321|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phenylobacterium haematophilum|TrEMBL
MATTFKLNGREVTVKGPDDSPLLWAIRDELGLTGAKFGCGIGGCGACTVHLDGEPVRSCI
TPVSSIAGHAITTIEGLDPSGRHPLQLAWIEAQAPQCGYCQSGQIMSAAALLKSTPNPTD
AQIDDAMNGNLCRCMSYVRIKKAIKLAAAKMQGAKA
>A0A840H5E9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR18|TrEMBL
MNKHISPRLNRRAFVIGSATLGAGLAIGLDLPFGGPAVVRAADGSPEIGAWVVVRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELECDWTKVTTEYPTPGQSVARKRVWGDFSTGGSRGI
RSSQDYVRKGGATARVMLIQAAADAWKVPASECAAANSVITHTPSGRTTTYGKVAEAAAK
LSPPADVKLKDPKDWKLIGKGVKRLDTVDKTTGAMIYGADIKLPGMLNAAIKDCPVFGGK
LKSFDEAKIASMKGVKKVVKVGDTAVAVVADTWWHAKTALEALPIVWDEGDNAKVSSESI
AKWLAEGLNNDQPAYVGNKNGDAKAAIAGAAKKVEAVYSYPYQNHATMEPMNATALYTAD
KCEVWCGTQNGEAAFAAVLEASGLPADKCDVHKVMLGGGFGRRGQTDYVRQAVMIAKETP
GTPVKLLWSREEDMAHGRYHPITQCKMTGAFDANNNLVALHYRLSGQSILFSLRPEALQN
GMDPAAFQGVAQSGEAAFGYSVPNLLVEHAMRNPHVPPGFWRGVNVNHNAIYMECFMDEL
AQAAGQDPLEFRRKLMGNHPKHLAVLNAVAEKIGWTTPAPQGVYRGIAQVMGYGSYVAGA
AEISVTDGSKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGKIEQ
TNFDTYNSMRINEMPKVESVMVPSGGFWGGVGEPTIGVAAPAVLNAYFAATGKRIRSVPL
RDQNITFA
>A5EE70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MNRIIRDHSSTTSAGRPVNLSRRGFLGAAAGALVLGFDLPGTKAVAQGAAPVAKAPNVAA
FLEIRPDSTILLRSPFIEGGQGISTALAQIVGEELDADPATFVVECAPPGADYLVVGGAR
FTGGSFSVRASYATMRRVGASARQMLLQAAAARWRVPADSLSTEPGRVRHAASNRTLAYG
ELAADAAKLPVPETVALRPEKDFRWIGKPFARLDARDKSTGKVSYGIDLKVDGMLQAAVQ
HAPRRGQEPGAFANEAEVKAMPGVHSIHRLAGAVAVVAERWWYARRAVETLKVTWTEPAA
GAQGVVPANFSSEGRKAQLGATPGPGFDAEKVGDVTAGLAGAGRVITASYDAPYLVHGQL
EPPSAIARWNADGTLDLWLPNQAPEMFQAAAAKVAGITPDKVKLHSPPLGGFFGRHFVYP
PANPFPQVIQLAKAVGRPVKVIWSREEEFSRDAMRPLGFARFKGGLDKDGIPVAIEAEAV
GDGPLARWFGRKPDTADSSAVEGIAEKPYAIPHRRVAHVLVEDPNVLGFWRSVGHSMNDF
FYETFFDELADAGRQDPYQLRLRLLADKPRHKTLLEAVGELSGGWKRGPFTAADGSKRAR
GVAMASPFGSEVATIAEVSLKDGAVRVHDVWVAIDPGRIVNPAIIESQVNSAVALGLSSA
LLEEIVFVDGAPQARNFDAYPILPPDRMPRVHVRIVESGAPMGGIGEPGLPGVPPAVANA
VAALTGQRVRSLPLSKVKFEEAAGRT
>H1KLD5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens DSM 13060|TrEMBL
MIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHLGGTAARACIT
PVSAAEGQEITTIEGLSPDGNHPVQVAWRDLNVAQCGYCQTGQIMQAASLLKDSPKPTDQ
QIDENMSGNICRCGTYPRIRAAIHQAAGQAPATKGDRL
>W8RT33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibacterium elongatum DSM 19469|TrEMBL
MANWGKITRRTLLIGSAAIAGGVAFGVWQYRRELPNPLDPAEGQATLNPWILIDQQGVTL
IAARAEMGQGVYTTLPALVAEELDVAWDDVRVMHGPAAQAYYNGALMSHGLPINDYERTG
FHETMIEAMTVLPKMIGLQVTGGSTSTIDAFEKLRMAGATARETLKMAAAERLNMPLGAL
GTRDGRVIAPGGIEMTYGDLAAQAAQIDPPRRVALKPPADWRYLGRSMPRTDTIAKSTGT
AEFGIDVRLPGMKFASLRRNPRLGGGMRRYDDSAARAMPGVEQVVDLGDGVAVVASNTWL
AMQAVDAIDIDWDDAPYPATSDALMGVIRAALDAAPNSTLRDDGEIDALEIAPEDRVIEA
EYTVPWLAHATMEPMNATALYTGDRLEIWAGSQAPGFAEQRAAEATDLDADQVTCHVTYL
GGGFGRRGETDFVVLAARVARAMEGTPVQLTWSREEDMRHDFYRPAAAARMRGVLRGGFA
SALEGRVAAPSVTRQSLQRMAGISPGGPDKGHVEGMFNQPYAIPNYRVTGHLADLDVPVG
FWRAVGNSFNGFFMESFMDEMALAARRDPLAFRLDLARREHAPSAGVLEAVAEMSGWTGQ
TPDGVGRGVAMTYSFHTAVAVVVEVSDRDGAVAIDRAWMACDVGTALDPGIIEAQMSGGL
IWGLSAAAMQEISFAGGEVEQWNFPDFDALRLHNSPEVEVRILETQHHLGGVGEPSVPPS
MPALANAVYDLTGERIRDLPLSRRVRFVL
>F7ZI76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter litoralis (strain ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149)|TrEMBL
MPTTFSVNGNSVTLDVDPDMPLLWALRDHLKLTGTKYGCGIAQCGSCTIMLDGFATRSCV
TAVGDVAGAEVQTIEGVESAAARAVQEAWTTLNVAQCGYCQSGQVLVATELLENTPKPTD
EEIDAAMGANICRCATYARIRKGIRAASDALEV
>A0A6J5GWB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinitolerans|TrEMBL
MTKLNVNGADHAVDAPPDTPLLWVLRDTLHLTGTKFGCGMGLCGACTVHLDGVAVRSCQL
PLGAVAGKRIKTIEGLGKPEALHAVQAAWRDEDVPQCGYCQSGQIMSAAALLATNHNPSD
SDIDAAMAGNLCRCGTYDRIRRAIHRAAVALRDKAAA
>A0A0C4Y058|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MTPINVNGALRAVQAPGDTPLLWVLRDELDLTGTKYGCGMGLCGACTVHVDGAPVRACQT
PVSTVAGKRVTTIEGLGQPDALHAVQKAWQAEDVPQCGYCQSGQLMSAAALLASKRNPTD
SDIDAAMAGNICRCGTYDRIRRAIHRAAAELRGGKPA
>A0A0F7Y8J9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. CCOS 191|TrEMBL
MNARIDTPDDLARLRSGETVNLSRRRFLAGSAIGALVLGFGLPLGSARVQAAATSPERGT
QVPAFLEIRADGSVHLLSPFMEGGQGVNTAMAQIIGEELDADPATFVVESAPAGEAYVVM
ENGLRITGGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPVGELSTEPGKVVHAASGR
ALGYGELAAKAMDLPVPDPASVKLRDPSQFRWIGKPVQRLDAYDKSTGKAVYSIDVKVDG
MLHAAVQHAPRLGMTVGNLRNEEQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEALQV
DWKEVAADSQVRPMPADFSSDGWREHLAAQTGPSRDEENHGDVAGALAAAKTKVEATYHN
QFLNHAQLEPPSATARFNPDGSLEVWLPNQAQDMFRDDIAKRTGLDPARITLHSPLLGGF
FGRHFLYDSANPYPQAIALAKAVGRPVKLIWSREEEFLRDAMRPMAVVKFRAALDEKGLP
VAIEAISATEGPTEAIAGKQGDTVDPTALEGLSGKAYAIANKRIAQIYVKGPAMLGYWRS
VGNSLNDFFYESFLDELADKGGHDPFELRLQLLRDNPRLTTLLQAVGELSGGWKRGPFTA
EDGSKRARGVAMASPFGSEAAVIAEVSLESGQVKVHDIWQAIDPGSIVNPAIIEAQVNGA
VSLGLSQVLLEESVWLNGMPRARNYDLYPVLPPSRMARVHVRIVESGAKMGGIGEPPLPA
VAPAVANAVAQLTGQRVRSMPLSRHTFS
>A0A0C4Y8M3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MSPGAQRDALLQARGVLLVTRAPQAAPRPAPGQPGAASDYIAAQPDIFVAVRDTGEILAF
NGHVDLGTGIRTSLAQIVAEELEVPAARVAMTLGHTEATPNQGPTIASATIQISALPLRR
AAAQAMAWLRERAAQRLGVAPEALIAEDGRLRLRGTGNENAEGLAYGDLLAGEHIELPLA
DAIATKPVSEYRVVGRAAPRVDIPPKATAQLTFVHDVRVPGMLHGRVVRPPYAGRDSGGF
VGTSLRGVDRASIRDVRGVVDVVVQGDFIGVVAQREEQAMQAARRLRVDWKPAPPLPPLS
EPDDTEAALRANPATRRTLVEEGDAQGAFDSADRILSRGYTWPYQMHGSIGPSCAVADYR
EDGLTVWSGTQNPHVLRIDLARLTGLDEGRIEIVRMEAAGCYGRNCADDVCADAVLLSRA
VGRPVRVQLSREQEHLWEPKGAAQLMDVRGAIGPDGELLAYDFVSRYPSNDAPTLALLLT
GVVDNAPRMLQMGDRTAVPPYQYAATRIGCDDTPAIVRASWLRGVSALPNVFAHESFIDE
LAHESGADPLAYRLRHLPDARATDLLRALAAHAGWREGARGTRGRPDADGLLRGRGVAYA
RYIHSKFPGFGAAWAAWVVDLTVAPDTGQIVVERLVVAQDTGMMVNPDGVRHQVQGNVVQ
ALGRVLKEQVRFDANGVASREWGSYPLLTFTELPPIEVLLMPRQEEAPMGAGESASLPGA
PAIANALFDATGVRLRRAPFTPEAVLAALAGQPA
>A0A7Y7I4I0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. SG517|TrEMBL
MTTTITVNGKTTTVDAEPDTPLLWVLRGEMKLVGTKFGCGKALCGACTVHLDGEAVRSCV
TPIEAVGAREVTTIEGLKGKEADALRRAWSEVDVVQCGYCQSGQLMSACALLRKTPKPSD
EDVSSAMSGNICRCGTYPRIRAAIHLAAGSVAS
>U2EQI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinisphaera shabanensis E1L3A|TrEMBL
MDFELNETQIALREAAEDFARSALAPNAAQWDAEAYFPREVIAQAGELGFCGLYTPEDQG
GLGLARLDSAMIFEALSAGCTSTAAYISIHNMATWMVATFGGDDVRDQWCGELTAGEKLA
SYCLTEPGAGSDAASLKTKAERDGDAYVLNGSKCFISGAGDTDLLVVMARTGKAGAGGIS
TFAVPADAPGISYGRKEPKMGWNSQATRTITFEDVRVPAANRLGEEGQGFSIAMKGLDGG
RINIACCSLGTAQAALDAARRYMSERQQFGRKLEDFQALQFKLADMATELIAARQMVWLA
ASRLDAGHAEATAFCAMAKRMATDRCFDICNDALQIHGGYGYIREYPLERHVRDVRVHQI
LEGTNEIMRLIIARRVLADHDGDRLR
>A0A7Y9RU50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides perillae|TrEMBL
MTEQLTPGVPASLARDLAAHDVGRRRFIGYVLGGATLVAAADMALAGTPAHAAVPSAPQV
PEIYDLNDFLTDSNRATANLITVTINEDGTASFDLHRAEVGQGVTTSTAMLIAEELDLPL
SKVRIGLADARPELLYNQLTGGSNTTISTFTPIRVAAAVAKGALLDAAAIVLGDTVALLQ
SKEGVITGPSGSITYGELATLAASDRVQQREVQLKAPSEFRVIGTPRNRIDALAAVTGRK
DYTTDLQVPGALPTMICRAPTLNGTPRRLLNPGEVKAMPGVTHVAVVSTGIAVRARTFGQ
AIDAVRAVRAEWNDGPVAGQSDEDIVAELRAAEVPMPKLPDLPLLAKTVSADFTFYFRSN
SAMDTNSAIADVREDRAEIWSGMKSPIYTQQRIAELLGMTQDQVTCHVVQAGGSFGRRLF
SDGALEAAEVSQAMGVPVKLMWHRADDARVGRAHPMCTSRINATYLAGQVLSFQQVHTSV
ETDYRHGLGEYFTSVAADLPAGLGNLGFAESIFTMTQEIPYNFGVVAQNLVEVDDRFNTG
SMRNIYSPDVRAASELVVDQLAKAMGKDPLRFRLEFAKEQRLRDVLNAVAKAGTWGRPMA
PGTAQGIAVHKEYKGVSACLVEIDCRPATVNREIREAVTGPRVTKVVYAIDAGLVVNPRG
LEAQMQGGINDGIALALTSSLHLRDGHFVEASWDNYFYTRQWNTPRDVEVIIMPSESGQV
GGAGEAGVAATFAAVACAFTRATGRQPTYFPINHQDPFPFEVKSYVPPVPASPTNGLNFT
Y
>A0A7X0E9H0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. A1T4|TrEMBL
MKLKTGRPQTTDQIDLNRRHAIQSGGLAIAFLWLGGSGIASAAINARRQPGDAAAALADG
NPAFAPNAFIRIGTDGTVRLVMPTVEMGQAIYTGSSMLLAEELGVGLDQISVEHSPPSDD
LYGMPLLGGQITGGSTSTRGTWQVLREAGAVARTLLVTAAATQWHVDPSTCTVDRGMVHH
IPSGRSVGFGAVASAAGQLPMPDKVQLTDPKDFKLIGKPLRRVDSADKIKGATQFGLDVR
VPGMKIAVVKACPTFDGKLASVDDKAARAMPGVVDVIRIADAVAVVGDHFWAAKQGLEAL
LIKWDRGENANLTTQQLRDALAESALNGKSIVAREVGSRPADGKTVESVYQLPMLAHATM
EPLNATIFVTSDKCEIWVGTQVPARVLDAAAKITGLSKDKIIVHNQYLGGGFGRRLETDS
VEQALALAKQVSYPLKVVWTREEDIRHDRVRPMYHDRISAVLDANGRPAWYGYRTSGGTV
LGRWAPMAMGKDGLDSDAVECVVEVPYEIPNLKVEWIRHDMPPGLIVGWWRGVGSTHNLF
VVESFMDELAHHAGKDPLEYRRALLQKNPRTLAVLNLAAEKIGWGAQPLPARVARGIALG
EPFGSRVCAIVEAEVTPQGEVRLRRAVVALDCGIGVNPSSIEAQIQGGLLFGLSAALYSE
ITIKDGAIEQSNFNDYRNLRINETPLIEVHRIENNEAPGGLGEVGTAIAAPALANAIFAA
TGVRLYKLPVDRNLLVQDANALKRVVSATAADQGRSDA
>A0A160VFL1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MKAATLDIPTEVALKDPSDFRIIGKELPRKDTPLKVNGSAQFAMDIDLPNMVYAFIVRCP
IFGGKLKSINDTKAREIEGVLDVFAVENGVAIVGASTWAALRGRKALVITWDEGPNKNVD
SKTIYEYLQKRGRKRGATGRRDGNAKRALNKADRVIEAVYELPFQAHATMEPMNCVVDVQ
SDLCRIWAPTQSPQQARKRASDITGLSINNVEVNVTFLGGGFGRRAFNDFIDDGLAVSKH
MGRPVKLIWKREDDMRHDYYRPASRHVLRGGLTKNTNTTAWTHRVVAPSIIFGQMFKYPI
PFKDKLDVVALEGAKDLPYEIPNIHVDYKSANTAVPIGWWRSVYHSQNAYANECFIDELA
FAANMDPLQYRLQLLPDDSRNSNVLQLAAKKAGWDGSTPTGRYKGLSCHESFGSYVAQVA
EVSIGKDNVVIVHRVVCVIDCGQTVNPSIVEAQMESSIVYGLSATLRGEITIEKGAVVQS
NFHEFEVLRMDEMPEIDVHIIKSTATPGGVGEPGLPPVAPAVANAVFAATGIRVRKLPIK
PEDLRS
>A0A3B0TAX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MRKGVKKISRRKFFVKGTLGTIGVLAIGTYLFRNPIRRSIAGYLNTADAPYLGNTDTPTI
WFETTADNNIVFHCPKVEMGQGAFTGLAQIAADELDVSMQQMSVVHAASASGNIDGFATG
GSTSVSSLWMPLRELAATMREMIKTEAAKKLGVEVTTLSVKNGIISNGEKTMTYAEAVKG
VTDWDIPDTPTLKDIKDYKFVGKPIARVDLKDKVYGKPMFGMDATMPNMLFGAVVRPTSV
GAAYVSANTSKAENMPGVIKIVKEDDFVGVIANSRMEAENAKNAIEVTWDIPKKWQTADI
EAMIEIGKGEPFVIQKEGNSESILEDDKNIVVSEFKSPIGAHAQLEPNGALAFVEENKAT
IMMSTQVIKITRAEIAKRLGFDDNQVNIVPTFLGGGFGRRLHTPNGIQAAILSKAIGKPV
KCFFDRKEEFQNDTFRPPTHHVLKAKLNTDGLIEAIEHSVSSGDVAFGSPMLPRIAEPIL
GADIGAWRGGMIQYGKIPHYRAISWRVKLPFATSWWRSLGLLANTFAIESFMDELALKSA
KDPVQFRLDQIQDDEKGHRLKEVIKAVVEKSNYKNEALNGRAMGFACSTDVNTPCAQVAE
VSIENNQIKVHKVTCAIDPGMAVNPDQIRAQCEGAIIMGMSASMHERMFVENGQLRPTIY
GPYKMALMKDTPKEIDVVILENADVPGAVGEPPLGPIGAAIANGVFRLTGKRLREMPFKL
A
>A0A5Q4ZFR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia dioscoreae|TrEMBL
MGSLNINGRAVAVQADPDMPLLWVLRCELGMTGTKFGCGLGICGACLIHVDGEANFACQT
LMSSLHTQKITTIEGLQGPEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKHNPRPTDA
DIDAAMCHIVCRCGTYPRVRAAIHQAAAKRRPA
>A0A7W6D9F4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MSIHDKVTLPVSRRHFLIGASLTASGLVIGLRPAPSSAAPEAFEAGAFIRIPAEGKIVFV
MPSVEMGQGIYTAVAMLLAEELEVSLDQVELEHAPADPALYANPLLGDQITGGSLAIRGV
YEQMRKAGATARVMLVNAAARGWDVAPETCTAEAGQVVHAASNRRAAYGSLVEAAAAQAV
PQEVPLKPATSFKVIGQSVRRLDSPEKVNGSAKFGIDARPDGVSYAAIALCPHFGGKLRS
LEDAPALAVKGVRQVVRIDDAVAVVADNTGAARKGLAALSIDWDPGPNGNLTLADLEGRA
ENAIEGSALPHINEGDVEKAEAEHGPVHEFVYRLPILTHTAMEPLNCTLHIRSDGCEVWV
GTQVMGRARQAVADVTGLPVDKVVVHNHLLGGGFGRRLDVDSVIVAAKIAQQVDGPVKVT
WSREEDIRHDCYRYLNYSKVTATLDADGMPVSWRHRVIGPSVMARWLPAFTRDGIDLDIM
AGAESPYAIANKYTDFVRHEAPDGMLTGNWRGVGATRNIPPVEGGIDELAHIAGVDPLEY
RRRLLQHKPRLLGALDLAAEKAGWSTAPAQGMGRGIAVAEDFGSFAAMIAEAGIAEDGSL
KIDRIVCAVDCGQVINPDTVEAQIQSGIVYGLSAALYGRITVENGAVVEGNFDDSPVLRI
HETPKIEVHIVPSSEAPGGIGEIGTPGVAPSLLNALFVVTGKRLRSLPIDQSELRRV
>A0A7W6DB11|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MTTFTINGRAVDVAAEPDTPLLWVIREHLKLTGTKFGCGIAQCGACTVHIDGEPTRSCQT
FLEDVAGREVTTIEGLSPDASHPLQKAWISEQVPQCGYCQSGQIMQAAALLEHTPAPTRE
QIIAHMDGNICRCGTYVRIISAIQRAAQEG
>A0A1Y0E9S3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Yoonia vestfoldensis|TrEMBL
MASFRKIARRSFLIGSAAIVGGVAFGVYQIRKDAPNPLVADVGEAVLTPFILLNQDGVTV
IAPRAEMGQGVQTTLAALVAEEMDVAWEDISVLHGPPAQAYYNQALLGLALPFRHYADTD
FRQSLRQGIGQVGKLLHLQVTGGSTSMKDGYERMRHAGASAREALKRAAAAQLGVAASDL
RTEASHVIAPDGRRIAYTALAEAVRDIPLSDVALRPRSEWKYLGKSMPRVDMLAKATGTA
QFAGDVPLEGMKFATVRINPKRAGMLSYDDTAARAMDGVEAIIDLGDGIAVVATNTWLAM
QAAEAVDIIWEEAAYPADTAGMMATIAAAFDRPPNSTLRDDGDVTAEIAGTEVVAAYTVP
FLAHATMEPMNATARFTGDRLEIWTGNQAPVMTRDRCAAAAGIAPEAVIVHTTLMGGGFG
RRAETDYSVQAARIAAALPGTPVRMTWTREEDMRHDFYRPAAMARFRGVVADGAAQLIDG
QIAAPSVFQQSSLRQMGQVPPGPDRAHVEGAADQPYAIPHFRITGHLADLGVPVGFWRSV
AASFNGFFLDSFIDEMAHAAGTDPLQFRLALAAREHAPSAGVIRAVGDMCGWTGQTPAHI
GRGVAFCHSFGTATAQVVEVEDTGRGIRINDCWIACDPGLALDPAIIKAQMISGAVYGLS
AATQEEVTFTDGAADQSNFTDYDALRMHTTPRFDVRILETSGHLGGIGEPGTPPAMPALG
NALFDLTGLRARDMPFIKTFDMIL
>A0A109B891|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. WDL1|TrEMBL
MPELAFKVNGRELELSVPAQASLLHVLRNDLSLNGPKYGCGLGQCGACTVWVDGVAARAC
VIPAHGVAGRAVTTLEGLGSRDSWHPVQQAFEQAQAAQCGYCLNGMVMQAAALLAREPRP
SDARIRAELSGNLCRCGTHVEILAAVHAAALRMAEDETT
>I0KDK3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrella aestuarina BUZ 2|TrEMBL
MPLASRSYSYGLRDLTVAFAFTISVKLVVTSVICIPVYRSIHETFVPVSFCPKRKAVPIS
QSPLLQLRIHHHLVNPTTVATYNLKVNGKIRRVDVDPATPLLWVLRDHLDLSGTKYGCGV
AQCGACTVHLDGTAVRSCQLPVSVVGKGAVTTIEGLAATAGSASLHPVQKAWLDHDVAQC
GYCQAGQIMSAASLLNTTPNPSDADIEAAMSSNICRCGTYLRIKDAIKSAAKK
>A0A132BW19|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter horizontis|TrEMBL
MRYTLKINGETKTVDAEPGTPLLWVIRDDLKMTGTKFGCGVASCGACTVHLDREPVRSCQ
TYIDDIEGAEITTIEAMQDDKIGAAVQQAWMELDVVQCGYCQSGQIMSAVGLLRDTPKPT
ADEVDSYMWGNACRCATYQRIRAAVLRASEIMEA
>A0A7U3ZGU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MAIYTLQINQKNYRVDVEEDTPLLWVLRDTLGLVGTKYGCGIAQCGACTVHLNGTAVRSC
VLPVSAVGKQKVTTIEGLSANGEHPVQKAWSEMDVPQCGYCQAGQIMTAAAFLNKNPKPS
PEQIEEAMNGNICRCGTYHRIREAVALAAAKRK
>A0A1E3GWW3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MKPRSEWRLIGRSQPRLDLPTKIRGAPVFGIDVAPPNLLYAAVRHAPVFGATVARVANEA
AVRALPGVIDVAVIDGRAVAVVAASWWRAERAAADLEIAWSRTDAAAVDSAALRDDLLAG
LESAEPYGHIDEGNVDAALSAPQAKVVEADYDVPFVTHACMEPINATALLLADGTAEVWA
SSQTPVAMRGGATQGMGWAGVTPTRVVPHVTMAGGAFGRRSDRDVIAEAAFLAARHRGRP
VKLIWSREEDIGRGLYRSHAAARLAAALGPDGLPVAYDARVAAQAAFHSIAGRNFPVTPG
PDGEFLTVEGLDKRHYSIPYRRMRSQQVPSHVPIHFWRSNGFSFNTFFSESFVDECALAA
GTDPLAYRRNLLRDSPRHRAVLDRAAEVADWARPLPPGRGRGIAIEECYRSVVAQVVEVT
ALGERGIRVDRVVCALDAGLILNPDQVVAQIEGGILFALTTALLSRISFEQGAVVESNFT
DYPMLRLATAPDIEVALVDSPLPPCGVGEPGVVPTAAALANAIHAATGRRLRSLPLDVTV
AGLASDT
>A0A5P9GG25|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF33|TrEMBL
MTINTSRRGFLKSAAAAGAVLLVGTRPDGALAAASSETAQFNPFVKIDADGTVTAIVKHF
EKGQGPATGLPTLIAEEIGLTMDQIEYEFAPSDPNVYNNLLFGPFQGTGGSTAMANSWLQ
YRQAGAAAREMLINAAAQSWGVDASGITIEDGIVKAGDKSAPIAEFVSAASQLDAPAEPR
LKDPSEFRLIGNETVRRKDTAIKSNGQAMFAMDVHLPNQMIAMIKRPEAKGGIALGFDDS
ASKEVKGYISAAVLPNQAGVAVYAENTWAAIQARDALEVEWDMSGAETRNSDQIKAEIMA
ALEAEPTYNVNKADFAAVAAAIDGADKVVEKTFYFPLLAHAPMEPLNCTIEQTADGDIVL
HDGAQMPTGPHMAYQQIFGLPAEKIHIKTMLAGGSFGRRATPDADYQVEAALAFVVTDRS
RPVKLVWTREDDIRSGYYRPAFGHKVRVGLDAEGNIVGWQHQIAGQSVIKGTPFEAVLVH
DGIDHSSVEGVSDSPYSIPGMAVGLTDTPKATTVLWWRSVGHTHTAYAMETMMDLVAEAA
GRDPVEFRLAHLSDSSNPDQQRKAAVLKLAAEKANWGNAPEGRSQGIAVHKSFGSYAAEV
VEISGDPESGIRIEKVTCAVDCGIAVNPDIVRAQMEGGIGYGIGHVMRDQITLTSGAVDQ
YNFPDYEPLRIGDIAAIDVHIVPSAEAPTGVGEPGTPPSAPALANAIKALSGLHVAQLPM
EEHGVSFA
>A0A508X085|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium medicae|TrEMBL
MFAAFRIHAPQREENTMVNIKINGVEHAIEAEADMPLLWAIRDLVGLTGTKFGCGMAQCG
ACTVYVDGSPTRSCQTFIGDIDGAEVTTIEGLKGKVAETVQSVWAELDVPQCGYCQSGQI
MSATDLLASNPKPTDTDIDAAMSGNLCRCATYHRIRAGIHEAAKRLEA
>A0A508X5V2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium medicae|TrEMBL
MARLTINGEIRDIEVAPETPLLWALREQAGLTGTKFGCGIAQCGACTVLIDGVATRSCAL
PASAVGPDQQILTVEGLSNDATHPIQQAWLALDVPQCGYCQAGMIMAAAALLNSTPTPTD
DDISAEITNICRCGTYNRVRAAIKLAAETMSASRKG
>A0A839NLS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium sp. JUb56|TrEMBL
MTTDKTTLGRRSFLKAALLAGGGMILHFNWPGAGAMASEPGPVADAIIELNSYIKIYPNG
DVLLFNPNPEFGQNVKTSLPMILAEELDVAWEKVTVEQADFFPERYGRQFTGGSQSVRQA
WPVLRTAGATARQMLIIAASEKWAVPLSEIHTEAGVIFHKKSDQKITYGEIASQAAQVPL
PKDVKLKDVADFKVIGSSKQNVELDNIVTGKPLFTSDYKQEGMLIAMIVHPPAFGQEITA
FDDTAVRQMPGIKDVFLIEPLAKDYTRNYFDTMSFGSLAVVVGTSTWEVMQAKKKLQLEL
QTASKRKNKDTLQLESTAGHYADMDRYAKIPGEVKRKDGDPDAAFKNAARIIERTYTAPF
LVHNTMEPVSCFAHVTADLAELYAPIQAPEVITTTLVARLGLPKEKIKIKLARMGGGFGL
RAYGHHLVEAAVISQKLNAPVKLMYTREDEATYGIYRPTYSATYRAALDNNNQLIGFHVK
AGGIPESPLHENRFPAGAVNHYLAESWAVDSDITIGAFRAPRSNFMASAEQSFLDELAVE
MKKDPIDFRLELIKRAKERPVGQRNDYDASRYAGVLQLLKEKASLLKKPDGTGRGIAAYF
CHNTYAAALVDIGVKNNEPYVVQAIASVDCGIVVNQDAAVNMAEGAVIDGIGNALYGEQL
FADGVPQKSNFNTYRIIRMSECPKHIEVHFVQNQENPTGMGEPVFPPMFGAVANALFHHT
GKRYYNQPFMKQYLAHGTQG
>A0A5E6QIF9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGQDQELNVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPVRACVT
PATAVAHGQKILTIEGLSIDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAIKRAADIG
>A0A5E7NF50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIAFTVNGERRELDEASSSMPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPAAAVAGHSITTIEGLSPTQSHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
DSIRNAMSGNICRCGTYGRINKAIKRAANAPKEA
>A0A8B4I7M6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MISPLITVALEVNGDTREVSAMADTPLLLVLRNDLALNGAKYGCGLGECGACTVIIDGVA
ARSCVFPLSGAAGRAIVTLEGLGTRQGAAPGATGVYR
>B8KXV6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luminiphilus syltensis NOR5-1B|TrEMBL
MTTLNINGEVREVSVDPQTPLLWALRDTLAMTGTKYGCGIAQCGACTVHVNGAPVRSCQL
NVGDAEGMEITTIEGAESKAIEALRVAWNELDVPQCGYCQSGQLMSAASLLERTPKPSDQ
DIDNAMSGNLCRCATYQRIRAGIHRAADILEA
>A0A5E7TFI6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFTLSNLSRRGFLKGVGATGALVVAASWGWQDAFAEEKEKKFGADGMPHGWVDD
PKVYVSIAADGTVTVICNRSEMGQGVRTSLTMVVVDELEADWAMVKVQQAPGDEARFGNQ
DTDGSRSMRHWYEPMRRCGAAARAMLEQAAADQWKVSVGECQAQLHKVIHKPSGRELGYG
SLAAAAGALAVPARESLRLKQPSEFRYIGKEGTKAIDGEDIVNGRAVYGADVHFDGMLYA
TIARPTVYGGKVKSFDGSAAMKVPGVVKVVQIESRPLPSEFQPLGGIAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNLDEAMASADSTLEASYYLP
HLSQSPMEPMVAIARFKDGACQAWGPSQAPQVTRERIGERLGLPFDKVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNIRLENPEATVRTRVGWYRSVSNI
PHGFAIQSFIDELAHKAGQDPLKYQIRLLGPDRQIDPRTLSEEWNYGESPERYPIDTARL
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLVVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLSGWQKAGA
>A0A5E7TDR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVAGQNVTTIENLHVDPVGQVVQQAWLDTAVAQCGYCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E6XXS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGSVIGQNVSTIDNLHADPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKINPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A4YPZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MTESATVTADHLRGVLTVARGMSDGCSETFIRITAAGEVSAFNGHVDLGTGIRTALGQIV
AEELDVSFARVLVVLGDTAVVPNQGATIASETIQITAVPLRKAAAQARGFLLARAAAQLG
LSEHDLTIEDGLVRGPDNRVLSYGELIGNDTIRLELAEDIAVKSADNYQIVGRSVPRVDL
PAKATGELTYVHDVRVPGMLHGRVIRPPYVGVDAGPFVGTSLIGIDKESVRDVPGLVDVV
VIGDFIGVVAEREEQAILAAERLQVSWKPVPTLRDLDDVETALRANPSEPRRLLDKGDVD
AAIAGAAKPMRRTYLWPYQMHGSIGPSCAVADVRDGHIRIYSGTQNPHILRADLAKLIDC
PEHQIELIRLEAAGCYGRNCADDVTADALLLSRAVGRPVRVQLTREQEHLWEPKGTAQLM
DVNGGLDADGSVAAYEFATRYPSNGAPTLALLLTGRVAPEPAVFEMGDRTAIPPYDYDHM
RVTAHDMAPIVRASWIRGVSALPNTFAHESYIDELAAEAEVDPIEYRLRYLKDERARDLV
NAVAERAGWTPRPVRQEKTPENGVVHGRGFAYALYVHSKFPGYGAAWSAWIADVAINTTT
GDISVTRVIAGQDSGLMINPDGVRHQIEGNVIQSTSRALMEEVPFARGKVAAREWGAYPI
ITFPDVPKIDVLMLPRPDQPPLGVGESASVPSAAAIANAIYDATGVRFREPPFTPERILK
GLRGEQVEPAKPQPLPAPEKPAATWLQPFAKRSGVMASAVAACAAAIGVAMAVLPWRAIA
PITRPDPSVYSAATIARGEVLAALGNCAVCHTSDGGLINAGGRALETPFGRIFSTNITPD
VETGIGAWSYPAFERAMREGVHRDGRQLYPAFPYTHFARASDADLQALYAYLMAQQPVRQ
QSPDNQLRFPFNLRPLVAGWNALFHSTETFKPDPTQSEQWNRGFYLIESLGHCSACHSPR
NALGAEQRNAYLAGGFADGWEAPALTALSSAPIPWTDDELFTYLRSGQSRFHGVAAGPMA
PIVKDLAKLPDADIRAMAAYLASFQTPSPEPAKLEAIASDLEARTKVTSASSPAARLYLG
ACAVCHEVGGLPLFGSRPSLALNSNLHSATPDNLIQVILHGIMKPASSDLGYMPAFKDHL
SDAQLAELVSYLRGQFAPDKPAWTDVEDAVSRIRSTIPH
>A0A2K8PNP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces lavendulae subsp. lavendulae|TrEMBL
MAEQSGATATGSARPSDDGQGATGSSRRSFLTYLVAAPTLALITRAGADVLAPQPAHAVI
PTLPAVADLVDLGDLFILAGAPTSALLALAVETDGTIRFRLPREEVGQGLTTAVAMLVAE
ELDAPLGSVRVELDDARPELLFNQLTGSSNSIRSLYGPVRQCAAGARARLVAAAAARWNL
PASRLTTAGGVVRAPDGRTADYGSLSAEAAAPGLIVLGASPKPAARHALVGTPTRRIDAR
AMVTGAQKYTLDLDVPGAKPCVVRRPPTLGGAVRGVSNLAAVRAMPGVLHVVTVPTGVAV
VAETFGQALDAKAALQVVWGPGPADQLSDAQIRTRLRAATPPLLVPPLLTPYVDAEFDFA
FVSHAPMETNSAVADVRDDRAEIWSGLKSPIVARETIAADLGLPLDKVKVHVVQAGGSFG
RRLFFDAALEAARISKACRRPVKLMWTRVDDTRHGRMRPATHHRIRATHLLGEVLSFEHR
VAAAETDFRHGLGEIITATAASLPSGIGNATLAQTLFLTTVKSPYHFGLTTQTLNEVPTG
IPTGSWRSVYSANTRGAEEIVVDELAAATGKDPYRFRRTFLKTDAQRAVLDKVAAEGEWG
RALPAGCAQGIAFHEEYKSRTACLVEIDTRDPEHVRVTRAVIAVDVGLPVNPSGLEAQMI
GGLTDAISTTLRAGLHLDKGLPLEGSYSQFHWAKQRDTPLDVRVFVLPATGTDPGGAGEL
GVPAAVGAIANAWARATGSKPRSFPLDFDVDFTPYPR
>A0A7X0E630|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. MP1X3|TrEMBL
MKLKTGRPQTTDQIDLNRRHAIQSGGLAIAFLWLGGSGIASAAINARRQPGDAAAALADG
NPAFAPNAFIRIGTDGTVRLVMPTVEMGQAIYTGSSMLLAEELGVGLDQISVEHSPPSDD
LYGMPLLGGQITGGSTSTRGTWQVLREAGAVARTLLVTAAATQWHVDPSTCTVDRGMVHH
IPSGRSVGFGAVASAAGQLPMPDKVQLTDPKDFKLIGKPLRRVDSADKIKGATQFGLDVR
VPGMKIAVVKACPTFDGKLASVDDKAARAMPGVVDVIRIADAVAVVGDHFWAAKQGLEVL
VIKWDRGENANLTTQQLRDALAESALNGKSIVAREVGSRPADGKTVESVYQLPMLAHATM
EPLNATIFVTSDKCEIWVGTQVPARVLDAAAKITGLSKDKIIVHNQYLGGGFGRRLETDS
VEQALALAKQVSYPLKVVWTREEDIRHDRVRPMYHDRISAVLDANGRPAWYGYRTSGGTV
LGRWAPMAMGKDGLDSDAVECVVEVPYEIPNLKVEWIRHDMPPGLIVGWWRGVGSTHNLF
VVESFMDELAHHAGKDPLEYRRALLQKNPRTLAVLNLAAEKIGWGAQPLPARVARGIALG
EPFGSRVCAIVEAEVTPQGEVRLRRAVVALDCGIGVNPSSIEAQIQGGLLFGLSAALYSE
ITIKDGAIEQSNFNDYRNLRINETPLIEVHRIENNEAPGGLGEVGTAIAAPALANAIFAA
TGVRLYKLPVDRNLLVQDANALKRVVSATAADQGRSDA
>A0A7X0E313|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. MP1X3|TrEMBL
MSDDLLSNHISNRGIQLSRRRFLQVLAGGAGALMIGIRMADAADVDVPLPPSLLGDTFYG
IGAYVRIDTDGNVLIGVRDPDTGTGVATSLPRIIADELDADWNRVSVVSLGLGVTNNNGE
PSWIYGRQVGGTGGSISAAWADLRQAGAVARWLLLQAAARRLGVPADRLRCESGTVIALD
GRRFTYGSLIEDASKIDMPNSVPPLKTGERYQLIGKPAGDVDAREIVTGQTRFAIDQQYG
DTLTAVVVHCPWPDGTLEGIDFTDTLAVKGVVKVLQLNPEAGQQTGTTLSTITVAVVAED
TWSALKGRQKLKLKWKPGASNSESSDALEQQAGALLAGNTDPTTRVRNDGDVDAAGKKAA
RRLEATYFQPWLAHATAEPMNCLVRVEKDKATLVVPTQAPQKAWAVVHRLTGLTPDQIQI
SVPRVGGGYGRRLDHDYVAEAVMLATNKDINKSVRLMWTHEQDLDHDYYRSGSVHQLSVV
IDHKRQITGWNQRMASASTLVNRGVPDSRLWTSEVDVDQLPAALVPNYRSDWYGQTSAIP
RGPARSMPHLSNAFAVESFIDEIAHSMKEDPLDTHLRLLGEAREVPLSGGGTFDTGRLIN
VLKLVADRIEWKNWLHSVNGLGIACWHFNGAYVAHAIEVASKDQKLVIQRVVCAVDVGRI
INPMGLEGQVAGATLDALSTALNLSITFKDGQIQQHSGKDYPLASMAQLPDAVEVITVPG
DRDPAGASFLAMPTAAPALANAVFRATAVRIRRLPLTKELSRLS
>A0A7X0E668|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. MP1X3|TrEMBL
MLSLSVNGESHSVDVPADMPLLWVLRDVIGLMGTKFGCGIAQCGACTVHLDGQPVRACVL
PVGSIGSKAITTIEAIGDTPSGQKVQQAWLDVDVVQCGYCQSGQIMSAAALLKRSPNPSD
AEIDAAMSGNICRCGTYVRIRAAIKQAATGKLEILQTIVTSPEGAAS
>A0A165PL14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. W74|TrEMBL
MIRFQLNGNSVTTGVNEDAPLLYVLRNDFSLNGPKFGCGASACGACTVLVNGQAVRSCIA
PVSLVADTEVVSLEDQTPDSVLSVLQQAFLVEQAVQCGYCSNGMILTATELLSNNPAASD
AEIREGMDGILCRCGAQARVLKAIKRAQVQI
>A0A654DW50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinoscillum sp. 108|TrEMBL
MASFTLKINGSSQSVEVDPDTPVLWVLRDHLRLVGTKYGCGMAQCGACTVLMDGYAVRSC
SLPVSAVGDKAVTTIEGLSEKGDHPLQLAWEEKDVPQCGYCQAGQIMNAAALLSQNPNPT
DEEIGAAMNGNICRCGTYTRIKAAIKTAAQTN
>W6R3U8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas pseudoalcaligenes (strain CECT 5344)|TrEMBL
MITLNLNGKDHELDVADDMPLLWALRDVANLTGTKYGCGMALCGACTVNVEGQPTRSCVT
PVSAVVGKRISTIEAVGEDAVGKVVQDAWRQLDVVQCGYCQSGQIMAATALLNSNKAPSD
ADIDAAMSSNICRCATYVRIRAAIHEAAGKLT
>A0A7Z0B3R6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MSPRSTDAMRGAPGVAASASRRVFLKSGLAIAGSFVLPLSFSELAWAGEGGAPSYEINDW
VRIDASGHTVIGLSQAEVGQGVYTGLPQVLADEMDADWRNVTVTFVTGRDAYRIDAANEM
PQQFVGASMSVTMFYERLRIAGAQARAAFIEAGARRFKVRGTQCTAANGQVIHIPSGRAL
SYGELVAEAVKIPLPAHPRLKPASAHTLIGQPLHKLDAPAKVNGSAQFGLDVHVPGMLTG
AVKMAPTLGGKPLRVTNADTVRKMPGVVDTVLAKDALIVVADTYWQAKLACDAAQMEWDT
PAGGPFDSATILDERKGALQSAHTVVATCLGDPQARFADAGQSSAVVVQADYHTPYLVHA
TMEPVNATVHVRDGEVEVWGPIQGQDKVRWTMAAMFKVPAAKVIVNTTFLGGSFGRKYVP
DFVVHAAVASKAVGRPVKVIRSREDDIQHGFYRPCASARMRAVLGKDGLPTALHARVVGQ
SLYKSIKPDFFDKAGGWDETMLDGIYDLCYGVPNLLVDSLHVPQPIPVSFMRSVGSTSSV
FFLESFIDELAHTAGIDPLRYRRALLRHDPLSVAVLDHAAARADWFGKSAPGLHRGIAFC
LYTGRGGAFTTYVATIVELRLVHRQVKVERVVCAVDCGRPINPMLIQEAIEGGIGFALTN
TFKSEITFAKGAVVQSNFADYPLLNLSEMPKVETVIVPSDRAPQGCGEVALPPVAPAVAA
ALFRATGQRLRSMPLPQRFDV
>A0A7W6LHK0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium rhizoryzae|TrEMBL
MAFSITINGQTHTADVDGDTPLLWVIRDVIGMTGTKFGCGQALCGACTIHIDGVPTRSCV
TPIDSIAESRITTIEALETLPHGKALQDAWIELEVPQCGYCQSGQLMSAAALLAETPQPT
DADIDSAMSGNVCRCGTYQRIRAAIKLASA
>H0T9B7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MNQHVKAAPAMAADLSRRSFLVGTAATGLVLGYAGLADSALAATTPTSFEPTVWYSIAPD
GLVTVTCGKADMGQHIASTMAQIICEELGAAWKDMRVQLASNDPKFNDPVLGAQITGGSW
STMMNFDAMSRAGAAGRIALTEAAATAWACRPRSSRCATAS
>A0A292Z417|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. N23|TrEMBL
MTPIDLVVNGERRSVTVGDDDLLLDVLRGLGHTSVREGCGVGACGACTVLADGHSVSSCL
ARAVRYDGVALTTADGLPAADDVVEEFVAARAMQCGYCIPGFVLMGHELLAENPDAGAAE
IDAHLEGNICRCGTYLEIRTALENAARRRREATRTEKEPA
>A0A7W7A8H2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium taihuense|TrEMBL
MTKIVVNGQEREVKASPDTPLLYVLRNELGVKGVKFGCGLAQCGACSVLLGDEEVRACVT
PIAALDGKPVTTVDGLPARWAQKTGLKPDPQRLHPVQQAWVDEQVPQCGICQFGMMIKVT
ELLEANPKPSDAEITEALTTSGPSPHLCRCGSYAAILEGAHRAARLMAEGGAA
>A0A7W7ENE5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas yabuuchiae|TrEMBL
MELSRRNILVGGGVGAGLVVAWGLWPRAYPPSLTTEPGEQAFGAWLKIGRDGIVTVAVPQ
AEHGQGIATTLAQVVADELGADWRTVAVEPAPPGPLYANPVGVDSLFEGAFGRLPEGMRD
EWLRRDRAMLTAGSSSLRMFEGPARAAAATARALMTQAAARRWGVDWSECEARDGFIVHG
DQRLRLAELAEAAAGETVPHPLPLGSGGAGKLAGKDVPRLDSPAKLDGSANFTADIRLPD
MVHVALRHAPLGRTRAIRIDRAAAMKVPGVVEVIEGEDWVAVAASSWWIAQKGLDAAAPR
AVSDGAVPTSQAITQGLEAALKEEGHSVLTRGDVAAALEGPGLIEARYRIGTGVHAAIEP
RAAVAAWPDGGLELWAPTQAPEAARKVAARAAAIPEDRVIVHAMPIGGGFGQGLEQDAVA
QAAMIAAKLKRPVNVQWSRTEDLRRDAWRAPAIARMTARLERGKLVGWRGRIATPSTGRA
LAERVMPAGLVRWGMRGQGRGDAYAMGGAVPPYAIPALAVHHHDASLPIPTGHVRGGAHV
ANCFVAESFIDECARAAGADPLAWRIAMLGQEPRLARCLSTAASLGGWEGGGPGSGQGVA
AHGFRGSYVAVMAETHRDENGRPVVDRLVAAIDCGRVVNPDIVRQQVEGGLIFGLAALRG
GAVGFERGWAVPSQLGALNLPRLADTPDITVELLSSDEAPGGVSELAVPPVAPAIANALA
TLPGFPRIRSLPMELSA
>A0A6S7CHR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter pulmonis|TrEMBL
MMDTAQRARRDFLKGGLGALTLAVTGSGLVSAVRAAGAEPRKYGADSMPGGTVDDPLVFV
SIAPDGTVTIVAHRAEMGTGVRTSLPMVVADEMEADWARVRVVQAGADEARYGNQNVDGS
RSVRHFLLPMRRVGAAARQMLEAAAAARWSVPRDQVRATRHEVVHDASGRRLGYGELAAD
AARLPVPAGDALRLKVPADFRYIGKSEVRLVDLEAIGKGQAAYGMDCHLPGMVYAVVARP
PVVGGKPHRVDSAKALAVPGVLKVVDIPPMQGAPAFQPLGGVAVVARNTWSAIQGRAALE
IEWDDGPNGDYDSAAYRQTLAAASRAPGKVMRDQGDAPGAWAQAGEAERFAADYHVPHLA
HASMEPPVATVRIQGDQAEVWTSVQNPAAAQEAVARRLKLDPAKVKVNVLLLGGGFGRKS
KPDYVDEAAIVARAMPQGTPVKLVWTREDDIHHDYLHTVSAERLEAVVDQDGKVRSWLHR
SAAPTIGSLFTEGAQGEQLFESAMSAINMPYVIPNVRVETAPVAAHARIGWFRSVSNIPH
AFAAQCFIAELAHRAGKDHKQYALDLIGPARRIDPGTLADTWNYSESPERYPYDTGRLRG
VIEAAARGAGWGRELPRGHGLGLAFCYSFMSYTATVVEVAVDAKGEVQVLAVDMALDCGP
QINPERIRAQMEGGAIMGLSLALLGEITFERGRVKQNNFYDYEVLRHGASPRVIRTHLVN
DDHALPPGGVGEPPVPPVAPALCNAIFAATGKRVRDLPVRTVA
>A0A1X1PBK2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia puraquae|TrEMBL
MATLNINNRSVEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTL
ALQAVGNARITTSEHLAGDAIGKAVLDAWVRHDVAQCGYCQSGQMMSAVGLLRGNKAPTD
ADIDGAMAGNLCRCATYQRIRAAIHDAASALA
>A0A5M9I2C6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas panacis|TrEMBL
MNTPSVIPGLTLGEPINLSRRRFLASTAVGALVIGFGLPLGSARVQAAAAAERGTQVPAF
LEIRPDGTVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAYVVMENGMR
ITGGSMSVRMSYPVMRRLGALARAMLLQAGAEQLGVPVAQLTTQPGRVVHAASGRSLGYG
ELAGRALDMPVPDPAGITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYSIDIKVDGMLHAA
VQHAPRLGMTVGSLRNQSQVEAMKGVHSVHVLPGAVAVVAERWWHAKRAVEAIQVDWQEP
TADSKVRGMPADFSSDGFRDFLAAQQGPARDDENEGDVAGALKNAKTQVEATYHNQYLNH
GQLEPPSALARFNPDGSLEIWLPNQAPDLFRADIAKRAGLDPAQVTLHSPLLGGFFGRHF
LYDSASPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAVVKFRAALDADGLPVAIEA
VSATEGPTEAIAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGNSL
NDFFYEAFLDELADKGGRDPYELRLHLLRDNPRLTTLLKAVGELSGGWKRGPYTAEDGTR
RARGVAMASPFGSHAAVIAEVSLENGQVKVHHIWEAIDPGSIVNPAIVQAQVNGAVALGL
SQTLLEEAVYVDGKPRARNYDLYPILPPSRMAQVHVKIVESGEKMGGIGEPPLPAVAPAV
VNAVAQLTGQRVRSLPLSRHTFS
>A0A031GFJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MYNMTVNGQPFGTEVDAETPLLWVLRDEVKLKGTKFGCGIGMCGACTVHVDGRAMRSCIT
PIAAVAGCAITTIEGLSPDGTHPLQRAWLATQAPQCGYCQSGQIMQAATLLKDYPQPTDA
NIDAVMSGNLCRCMAYVRIRKAIKLAAGMQEAPGV
>A0A0D5VEZ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MSTSFVLNGKNVTVDADPTTPLLWAIREDAGLHGTKFGCGMAQCGACTVHLEGEATRSCV
LPIAAIAGKRITTIEGIESRPAKAIQAAWVKLQVPQCGYCQSGQIMSATALLEHNATPTD
ADIDAAMNGNICRCATYTRIRAAIHEAAATLKA
>A0A071L8W4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MITLNLNGKDHQLDVTEDMPLLWAIRDVVGYTGTKFGCGMGLCGSCTIHIDGQATRSCIT
PVSLAQGRKVTTIDHLHTDKVGEVVQQAWLDIGVAQCGYCQGGQIMSATALLKSNPAPSD
EQIEAAMAGNICRCGTYNRIKTAIHNASAKLQEAKA
>A0A6J5EEH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia paludis|TrEMBL
MITLTVNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRSCIT
PVVAASGKRVTTIEGLSADLTHPLQQAWQELNVAQCGYCQSGQIMQAASLLKTNPHPGDA
DIDDAMSGNICRCGTYTRIRAAIRLAVRRGGAA
>A0A484VH28|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPGT
PAGWRALAFNGHVDLGTGIRTALAQIVAEELDVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAARWQVPATALRARAGRIVFADEADTRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGGLTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVARGDFVGVVADREEQAVAAMRALKVHWREI
PPAPDLGDLEAALRANRAEPRHLRDDGNTAHALATTPDTRRLRRSYVWPYQMHASIGPSC
AVADHANGRLTVWSGTQNPHMLRVDLDRLLDLGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLVDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGRVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLHHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGSDGLLHG
RGVAYARYIHSKFPGFGAAWAAWVVDLRVDPDSGHVTIDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPEIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRNALLARKQPGMPRADAPLSDTQPA
>A0A853T0C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. HH102|TrEMBL
MYNITVNGQPFGTEADAETPLLWVLRDEAHLKGTKFGCGIGMCGACTVHVDGRAMRSCIT
PIAAVAGCAITTIEGLSPDGTHPLQRAWLATQAPQCGYCQSGQIMQAATLLKDYPQPTDA
NIDAVMSGNLCRCMAYVRIRKAIKLAAGMQEAPGV
>A0A1A0D718|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus|TrEMBL
MPTLMINGQPHSVDVDADTPLLWVLRDILGLNAAKFGCGIAQCGACTVYVDGKAVRACNL
PVGLVGERAITTPEGLDMADPIVRAIKSAWVELDVVQCGYCQPGQVMAAVALLRTTPNPT
DEQIDSAMSGNMCRCGTYMRIRAAIHHAAGELA
>A0A5F0Z5G5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia marcescens|TrEMBL
MAISEVQSPRDGAKTTLTEHPLMLSVNGEQLHAQVMADTPLLLVLRNDLALNGPKYGCGL
GECGACTVLIDGVAARSCVIPALGVSGRAIVTLEGLGDRQRPHPVQRAFIEEQAAQCGYC
LNGMIMTTKALLDRNPAPSEAEIRQALSGNLCRCGTHLEILRAVQRAIILCRDEDAHAHD
>A0A679IXR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium bullatum|TrEMBL
MIKLTVNGAERSFDGDPDMPLLWFLRDEVGLTGTKFGCGQALCGACTIHLGGTAVRGCVT
PISAAEGQEVVTIEGLSPDGNHPVQAAWRDLNVSQCGYCQCGQMMQAASLLKETPKPSDD
QIDEAMSGNLCRCGTYPRIRAAIHQAAGNAPAANKGERL
>A0A0G3XBQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Croceicoccus naphthovorans|TrEMBL
MTRLTVNDRPVHFLMDADTPLIHALRDAANLTGAKFGCGNGDCGACTVIVDGQAIRSCLV
SLGEVEGRFVTTIEALSGDRSHPLQQAMVAEGAVQCGFCTPGMVMAGAALLARNPRANRD
EIAQSIPNICACGAGPRILRAIERAGRAIRSRERLDALPVPGLDPAEAALDVPAIEPEPA
PVESEE
>F7QKI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobiaceae bacterium SG-6C|TrEMBL
MAEELRDNQQPSGSLAIVRPAASDTTKPGFETFIRVGANGTITAFNGHVDLGTGIRTALG
QIVAEELDVSFARVVVVLGDTSQVPNQGATIASETIQITAIPLRKAAAQARHFLIARAAE
RLGLSAADLSIEDGLIRGHDNRSVSYGELIGEEVIRLELADDVEVKTADSYKIVGQSIPR
VDLPAKATGELVYVHDVRVPDMLHGRVVRPPYAGVDAGSFVGTSLIAVDESSVRDIPGLV
AVVQIGDFVGVVAEREENAIRAANQLKVTWKPTPTLPSLEDIENALRTNPGKPRTLLDRG
DVDHAIARADKPIKRTYVWPYQMHASIGPSCSVADVQDGTVRVWSGTQNPHILRSDLALL
LSLPESQIDVIRMEAAGCYGRNCADDVSADAVLLSRAVGKPVRVQLTREQEHEWEPKGTA
QLIDVNGGLNADGSVAAYDFATRYPSNGAPTLALLLTGAVAPVPAVFEMGDRTAIPPYDY
DTMRVVAHDMPPIVRASWFRGVSALPNTFAHESYIDELATEAGVDPIEYRLRYLKDPRAV
DLVKAVAKRAEWAPRPVWKQPEADGDVVRGRGFAYALYVHSKFPGYGAAWSAWIADVAVN
RSTGDVSVTRVVAGQDSGLMINPEGVRHQIHGNVIQSASRALMEEVSFDRTTVASREWGA
YPIIKFPDVPKIEVLMLPRQDQPPLGVGESASVPSAAAIANAIFDATGVRFRELPLTPER
ILAGLNGGKPAAPKALPNTTIQQQAQFRESRNPLVKRRGALAGIAAACAAVVGVATAVLP
WRSIPPIARPDASAYSAATIAKGQQLAALGNCAGCHTDIHGVINAGGRAIETPFGIIYST
NITPDPETGIGAWSYPAFERAMREGIHRNGRHLYPAFPYNHFAQTTDADLQALYAYLIAQ
PAVRATNRETALAFPFNLRPLMAGWNALFHKPAVFRADAAQSETWNRGAYLVESLGHCGA
CHTPRNALGAERDARAYLAGGVADGWEAPPLTSLSQAPIPWTEDELFAYLRTGASRFHGV
AAGPMAPVVKELAAVPDSDIHAMAVYLASFNETKITPAAQDALAARLEDATRARRTPSAS
PVGARIYEGACAVCHQVGGPVLFGTRPSLALNSNLHSAMPDNLIQVILHGIEQPVSSDLG
YMPAFRNSLSDGQVAELVSYLRQQFAPDKAPWTDLAATVDRIRRSAGP
>A0A0K3BJE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kibdelosporangium sp. MJ126-NF4|TrEMBL
MPTYTFSVNGKPVSVDVPADMPLLWVLRDKLGVKGPKFGCGIGVCHVCTSHLNGDEIQPC
VVPAAQAAGKEVTTIEGLADGEDLHPVQEAWLAEDVAQCGYCQPGQIMAAVALLKRTPNP
TDADIDRIENVCRCGTYFRIRQAIRKAAQKM
>A0A0J5QF28|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Puniceibacterium sp. IMCC21224|TrEMBL
MTVNTSRRGFLKGAAAATAVLLIGARPNGALAAGSDATNLNPFVRISADGRVTAIVKHFE
MGQGPTTGLTTLIAEELGVTMDQIDYDFAPSNPAVYNNLLFGQFQGTGGSTAMANSYDQY
RNAGAAAREMLIAAAAAEWGTDASGLDIVDGQITGNGHAAPLAEFVAAALTQGVPAEPRL
RTPDEWRLIGKESAVKRKDTPVKINGSGIFAMDLHLDNQMVVVIAHAPRMGAKVASFDAS
GAEGMTGFVMAKTLPDNSGVAVYAEGTWQALQAREAITVEWDNSEAEMRSSDVIRDELIA
AVQGDSTYQTKGVQTDTTALVDGAATIIDRTFYFPLLAHAPMEPLTCTIEATADGGAILH
DGAQFPTFGHMTLSHVLDLPMEKVQVKTVLAGGSFGRRANPTSDYNLECAMAFALTDRSR
PVKLVWSREDDIRGGYYRPAFAHRVRVGLDADGQIVGWDHRIAGQSIMKGTVMEPMTVKD
GVDGTSVEGVADTPYAVPGMSVGLTDHARATSVLWFRSVGHTHTAYVMESMMDMVAEETG
ADPLELRLSMLPGDTPAQTRMAGVLREVAKLADWQAGAPEGRARGLAVHHSFGSFVAEIA
EVSGGGADAIKIEKVFCAVDCGVAVNPDVIRAQMEGGIGYGIGHVMRNQITLTDGEVDQF
NFPDYEPLRISDIGAIEVAVVSSTDAPTGVGEPGVPPAGPALANAIARAGSERVTELPMM
GQVDFA
>A0A7W9ZDR1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novispirillum itersonii|TrEMBL
MSNITLSVNGKPQTVDVDPDTPLLWVLRDTLMLTGTKFGCGVAACGACTVHLDGVPTRAC
QTAVGDVGAARITTIEGAAASVKTDKVAAAVQSAWQDADVVQCGYCQSGQIMAAIGLLRE
TPKPTDAEIDTALNGNLCRCATYVRIRAAVHLAATRLEA
>A0A8F8EZ48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylovirgula sp. HY1|TrEMBL
MTRRDSVIRLIDPAALAPLSRRQLVTSCGGFLLSFAASPLAAKAHAKSQGEEPSLKKIQS
ETTPGSHKGYDGFKPAGFIRISKPDGIVLIIPNVEMGQEVYTAEAMLIAEELEVGLDQLR
VIPAPPNEDLYTQPILKSQSTGGSTSVRGAWVPLRQAGAVARTMLIGAAAAQWNVPTSEC
FAKRAVVTHRPTGRTLAYPDLGEAAFRQPVPKQITLKSPDQFELIGKPLPRIEGPSKVNG
TAQFGIDVAPPGMKIGTVMACPTLGGRLIDFDDRSARAIPGVRDVVRLADAVCVIGDHFW
AAQQGLRALRIRWDDGPNRDLTTEILENALKAASEHGKPVLARNQGDVSGAFERATKKLE
AVYQLPFLAHATMEPINVTVHVRPDACEVWVGTQVPTRAQNIAAKMSGLRPDKVIVHNYL
IGGGFGRRLTAEYVGQAVAIAKQVSYPVKIIWTRQEDIHQDLYRPAYYDRISAATGPDGL
PIAWIDHITGGSVMGRYLPQGLAQGQLDTDAVEGAAELPYDLPAIHVDWVRADPPIPISW
WRGVGPTHNVFVVESFMDELAHAAGRDPVEYRLALLKQDPRAANVLKIAAEMADWGKPLP
QGAGRGIALHNSFASYVASVVEISVAPTGEIALKRIVGVIDCGQCVNPDGIQAQMEGGMI
FGLTAALFNKITLRNGRVEQNNFNDYRMMRMNDTPPVEVRVVTSREAPGGVGETGTVAAM
PALGNAIFAATGKRLRRYPFDTNALQNPHADRTTLSQSVPVAPAPKEELADSPSLFLRAG
L
>B9BIB7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD2|TrEMBL
MVTLNINGETRTVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRRITTIEAVGATPAGQKVQQAWRALDVVQCGYCQSGQVMAAAALIASNPKPSD
ADIDAAMAGNICRCGTYHRIRAAIKQAAQEA
>A0A7Y9YII7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides marinus|TrEMBL
MPKQTFVLNGERVTVKVANDERVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVKVGDLEPDDEITTIEGLADTVKGDLHPMQEAWIDRDVPQCGYCQPGQIMAAVALVRKV
QREGGTITEADLDGIRNICRCGTYTRIREAVRQGARRM
>W6VD79|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. (strain GM41(2012))|TrEMBL
MTSQEITVALEVNGHTTTVTAMADTPLLLILRNDLQLNGPKYGCGLGECGACTVIIDGVA
ARSCVFPLAGAVDRQIVTLEGLGTRADPHPVQQAFIDEQAAQCGYCLNGMIMTAKALLDR
IPHPSETQIRNELSANLCRCGTHIEILRAVLRAARQTP
>K6W768|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola agarilytica NO2|TrEMBL
MSTNNDIKSLSRRDFLRYTSVAGGAFVLGTILPGVSPVWAASETDDSSNSLNLFVSIDNN
GTVNIVCHRSEMGQGVRTGIPQIVAEELCADWTKVNVVQGLGDEAYGSQNTDGSRSIRRF
YTTMREMGATARIMLEQAAAQKWNVSVSDVFADNGMIVHKPSGKTLGFGELAKAASAQHV
PQVKTLTFKSPKDFKLIGKPVTSVDLPNVLTGDTVFGQDVQLEGMLYATIERCPVVGGTV
KAYDKDAPLKVANVVEVIEMPKQHFPVLFKNLNGVAVLANNTWSALQGRQALNMQWDLGE
NQRHDSAAYLADLEKRIVTKGKSIRSAGDAYTAFDSANNTLSATYTVPYLVHAPMEPPAA
TAVFKNGQCEVWACTQTPQSTQQNVAGALGIDKSMVKVNVTLLGGGFGRKSKPDFSVEAA
ILAQKTGKPVKVVWSREDDIRHGYYHAISAQHFQAGLDDSGKVTSWVQRTAFPSISWTFT
GTTDEPQTGELSLGFGDLPFAIENLSCEVHKAPAHVRIGWIRSVSNIQHGFAIGSFVDEV
ATKAGISTSDMWLNLIGEDRIVDPKTQGFQYENYGESYDNFPIETKRLKNVLNMLLAKSG
ANNSTSENEGWGICVHRSFVSYVAVATKVKVENDKVTVLEMHSVIDAGRVVNPDRVKSQQ
EGAMIFGLSIALMGEITIKEGAIEQSNYHDYTVLRMHQSPKIVTHIVESDAAPGGVGEPG
VPPVAASVTNAIYHASGKRIRALPINKHYSV
>A0A2N9LRM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderiales bacterium|TrEMBL
MAALATPAAPISLVLNGARVELDADPATPLLWALRDHRNLTGTKFGCGIGKCGACTVVVD
GRALRSCVTPLEAVRGRKVTTIEGLATGGDAGASELHALQQAWITHQVPQCGYCQSGMLM
AALGLLNESPEPTDAQIDAAMDNICRCGTYPRVRVAIHSAARALRAAK
>Q13RB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia xenovorans (strain LB400)|TrEMBL
MGSLNINGRAVAVQADPDMPLLWVLRCELGMTGTKFGCGLGICGACMIHVDGEASFACQT
LMSSLHTQKITTIEGLQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKHNPKPTDA
DIDTAMCHIVCRCGTYPRVRAAIHQAAAKRRSA
>A0A7W5DAN4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. Sphag1AA|TrEMBL
MRRCASRSSCCLLLFTSDRREDARSTQGNHMISIHLNGKPQAFDLSPDVPLLWALRDVAR
MTGTKFGCGLGLCGACTVHVDGVATRSCVTPIGSLSGKRVTTIEAIGEAPAGKATQVAWL
AQEVVQCGYCQSGQIMTASALLAKHPEPTDAQIDEAMSGNICRCGTYSRIREAIKAAAVS
PILKRGA
>F8GX78|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MSTEDARSGAKRGKTTSHKRRRFLLGALGVTGALIVGWGVLPPRSRIGHASMFPGVDGEI
ALNGWIKIAPDGAVVIAVPRVEMGQGIHTAFAMLVAEELDVPLANVRVQAVTSERIYGNI
AGIADSSLPIHPDDWQKPWARAVHWLLSKTGRELGLIVTGGSSSVADAWLPLREAAASAR
AALIEAAARQWRAQAASVSIHEGMVIGPAQERVPIGAVAANAAAIGAPSEVRLKPASSYR
LIGRPAPRIDAQAKADGSATFALDVRPAGLCYAAVALCPVLGGSVGTINDAPARAMPGVL
GVVPFDGECGGCAGVAVIAEHYWQAREALERLQVTWIDGPYSTLSSADIDHKLSAELRGE
RDGFTYRKQGDGLAALPSPGTGIVLDVEYRVPYLAHAPMEPVNCTAQVRGGRVHLWAPTQ
TATLARMAAARAAGVDGDQVDIDVPLLGGGFGRRLESDFVAQAVRIAKHTGERPVQVIWS
REDDIRHDFYRPAAAARLRARVTGRDVDAIASRSVGQSILDQELRRILGTPGVGIDRYTT
EGLFDMPYAIPHQHIAHVNVDLPVPVGFWRSVGHSYNAFFLECFLDEVAVAAGRDPIDLR
RSLLYRHPRNLCVLDTVTRAAGLGAPGRIPPTDGKRALGVALHASFGSIAALITDVSLNN
GRLKLNRIVCAVDCGTVVNPQIVRQQVDSGIAFGLSAALYGKITFEHGRVRKANFNDYPL
LRMSDMPPVETHIVESADPPTGIGEVAVPPVAPSVANALFRITGKPCRSLPLEL
>A0A7W5DFH1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. Sphag1AA|TrEMBL
MTTLRINGKDLQVDADPSTPILWALRDTLGMTGTKFGCGAALCGACTVHLNGQAIRSCVT
PISAAAGQKITTIEAVTDGSDKVGKAVHEAWVKHDVAQCGYCQSGQIMSATAFLKTVTPG
KLPSEAEIDSAMAGNICRCGTYVRIRAAVADAAKALA
>A0A7W6T5B2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. SBR1B|TrEMBL
MNAHDSVSRRALLTGGLATGFLLAFHLPLRAAVNEPVQPRDATEGKFAPNAFIRIDETGH
TVLMMPQVEMGQGTYTSISAVLAEELDADWSRVEVQHAPPNDKLYGNPTFGLQVTGNSNS
IRAWWLPLRKAGATARAMLVQAAAAQWGVEPASCTASKGEVAHEASGRKLAYGALALAAQ
GQTPPKDVALKDPKDFVIIGQPLKRLDTPDKVNGKAVYGIDAILPGMKFATVAACPVFGG
KVGKVDDSAAVKLPGVRKVVVLDDMVAVIGDHMWAAKKGLEALKIEWNEGPNAAITTKDV
WDDLRKASQKDGAVAKSDGDIAKALASGDKFEAAYELPFLAHASMEPINATVHVKPDSCE
IWTGTQIMTRVQSEAAKAAGLPVDKVIVNNHLLGGGFGRKLEPDMVIAAVKIAKQVDYPV
KVVWTREEDIQHDVYRPVYRDQITASLVDGKVAGWKYKVAGSAVLARWLPPAFQKGIDID
AIDAAVDAPYDFANFHVEYVRAEPLSVPTGFWRGVGPNNNVFAVECAMDELARKAGKDPI
EFRKSMLTKNPRMLAVLGQVAEESDWGEPLPPRVGRGVCVQPSFASFIATVVEAEIDDIG
EIVLRRITSVVDTGIAVNPDTVKAQIEGGLIFGLTAALYGEITIDKGRVQQSNFHDYRMM
RINETPKIDVIVVKSGEAPGGIGEAGVNAGPPALRNAILAATGVALRRLPIDRKLLAAGK
KA
>C1AEE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)|TrEMBL
MSQGAPILLLVNGREHAVAMSEDTPLLWALRESMQLMGTKFGCGMALCGACTVHVDGAPT
RACVTPIGTLAGRSITTIEGLQGAVVEVVRAAWVNADVPQCGYCQSGQVMATTALLLQHP
MPTDADIDAALIGNICRCGTYPRIRAAIHAAAQQLLTASPAMPTSDSSSAPTPPPPSSSP
>A0A7W7WF88|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kitasatospora gansuensis|TrEMBL
MPTHQFVLNGKPVTVEAPADMPLLWVLRDKLGVTGPKYGCGVGVCRACTSHLDGAEIQPC
VVPVADCAGRQVTTIEGLADGDKLHPVQQAWLDCDVAQCGFCQPGQIMTAVALLRRTACP
TDADIDRIENVCRCGTYFRIREAIKQAADALD
>A0A7W8NAA8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. ANJX3|TrEMBL
MSDANRGIRLSRRRFLQVLAGTAGALVIGIRAAEAADTDAPLPPSLLGDTFYGIGAYVRI
DTDGNVLIGVRDPDTGTGVATSLPRIIADELDADWNRVSVVSLGLGVTDNNGQPSWIYGR
QLGGTGGSISAAWADLRQAGAVARWLLLQAAARRLGVPADRLRCESGTVIALDGRRFTYG
SLVEDASKIDMPTSVPPLKTAERYQLIGNPAGDVDAREIVTGQTRFAIDQQYGDTLTAVV
VHCPWPDGTLDGIDFTDTLAVKGVRKVLQLSPEVGQQAGTTLSATAVVVLAEDTWSALKG
RQKLKLKWKAGASNSESSDALEQQANALLAGKTDPTTRVRNDGDYDAASKKAARRLEATY
FQPWLAHATAEPMNCLVRVEKNKATLVVPTQAPQKAWAVVHRITGLSPDQIEIGVPRVGG
GYGRRLDHDYLAEAVMLASNKDIDTSVRLIWTHDQDLAHDYYRSGSVHQLSVIIDRKRQI
TGWYQRMVSASALVNRGVPDSRLWTSEVDVDQLPAALVPNYRSDWYAQTSAIPRGPARSM
PHLSNAFAVESFIDEIAHSMKEDPLDTHLRLLGDARELPLSGGGTFDTGRLINVLKLVAD
RIEWKNWLHSVNGLGIACWHFNGAYVAHAVEVATKDQKLIVQRVVCAVDVGRIINPMGLE
GQVAGATLDALSTALNLSITFKDGQIQQHSAKDYPLASMAQLPDAVEVITVPGDRDPAGA
SFLAMPTAAPALANAVFRATAVRIRRLPLTRELSRLS
>A0A7W8Q2L2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia atlantica|TrEMBL
MTNLLDSPSEQFPIEEQPRNISRRRFLLASVGTAAGALVLGFGLPVGRARAQAAANSAPG
TNVPAFLEIRPDSTVRLQSPFIEGGQGVFTAMAQIVGEELDVDPATFIVDTAPPGRQFQV
MDIGTRFTGGSMSVRSSYPTMRRLGALGRAMLLQAAAQHLRVPVGELTTQPGRVIHASSG
RSLSYGELATSAMDLPVPQPDSVKLKNPSEFRWIGKPMGRLDVHEKSTGKAIYSIDVRVD
GMLHAAVQHAPRLGMTVGSIRNESQIKAMKGVHSVHRLPGAVAVVAERWWNAKRASEAVQ
VEWHEPGPESTLRYMPADFSTQAFRDRLAAEPGSGDTAETIGDVSRALKDAHTTVTATYH
SQYLNHAQLEPPSSLARFNADGTLEVWLPNQAPDLFLADMVKRTGLDPAKITIHSPLLGG
FFGRHFIYNTASPYPQAVQLAKETGRPVKVIWSREEEFLRDILRPMAVVRFRAGLDENGM
PVALEAVSATEGPTEGIANKRDTKLDPTALEGLTGKAYTIPNRRIAQLYVKTPVMLGYWR
SVGNSHNDFLYETFLDELADKGGHDPYDLRMRLLQGNQRLTHLLSAVAELSGGWKRGPFT
AEDGTRRARGVAMASPFGSQTAAIAEVSIENGHVKVHDVWEAIDPGSIVNPAIIEHQVSG
AAALGLSEVLLEEAAYKKGMPVARNFDMYPILPPARMARVHVRIVESGAKMGGIGEPPLP
AVPPAVANAVSRLTGQRVRSMPLSQYNFKA
>A0A840C619|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chelatococcus caeni|TrEMBL
MRFFAPPVPSPALSRRRFLVLSGAAGAGLTLGLPAVRAAAQPAAAAGEAPFAAYLRIAPD
NTVTVLSAHLEMGQGAYSGVATLVAEELGAAPAQIRVDGAAGNPKLYGNLAWGGAMQGTG
GSTAMTSSFERYRRAGATARAMLVAAAADQWGVPAGEITVEGGVISHASGRRATFGELAE
SAARLPVPAEVSLKDPKDWTLIGSETFRRVDSADKSTGRQAYTIDVRLPGMLTAVVAHPP
RFGGTVRSFDATAAKAVKGVVDVVQISRGVAVIAEHTWAAMKGREALTVEWNLEAAEGRG
SAELMAEYKRLAAEPPTAVADRRGDAGAAFAGAARVVEATYEFPYLAHAALEPLDAVARR
EGDVLEVWGGHQMPDLYQAMAAEIAGVSPENVRLHVMMTGGGFGRRATPDADVIVEAVEC
AKAIGWRAPVKVLWTREDDMAGGRYRPMYLHAVRAAIDANGNPLAWQHRIVGQSIVANTP
FAALIKDGVDVTSVEGVSGTPYAIPNFTAELTTTSNGVPVLWWRSVGHTHTAYAMETMID
ALAKAAERDPVEYRRALLKDHPRHLRVLDLAAEKAGWSEPLTPGRFRGVAVHESFSTVVA
EVAEIAVDDKGGFRVERVVCAVDCGVAINPDQIRAQMEGGIGFGLGAVLHSQITLTEGEV
DQGNFDTYEVLRFSEMPRVEVHIVPSTAPPTGAGEPGVPPIGPAVANALAAAGRAVNVLP
LAQGA
>A0A0M6Y9Z2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium aggregatum|TrEMBL
MSVTLKINGETRTLDADPESPLLWALRDELGMTGTKFGCGIASCGACTVHMDGIPVRSCQ
TFVGDLEGAEITTIEGIDGKAAAAVQAAWNELDVPQCGYCQSGQIMAATALLAETPKPTD
EDIDAAMDGNVCRCATYARIRKAIHLASDKMEA
>A0A238H0S6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia singularis|TrEMBL
MSTTFVLNGKNLTLDADPAMPLLWAIRERAGLTGTKFGCGAAQCGACTVHLEGQAVRSCV
LPLAAVAGKRVTTIEGLSGKPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNAAPTD
ADIDAAMNGNLCRCATYTRIRAAIHEAASALKA
>A0A7W6Z4C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MTTDLDLKDAVRPSRRTFLKAAGAVAAVGLTIGFEWAGTGRRALAATMPDATFAPNAFLR
VAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWQDVRVESAPADAKRYANLAFGTIQ
GTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWQVPASELTTLDGSVHHAATNRTATYG
SLASAAARLPVPDTVTLKSPKDFRLIGQQVPRVDVPAKTNGTAQFTLDVTFPGMLVALLQ
RPPLFGATVKSFDASAAKAVPGVVSVVQVPGGVAVVAKGFWAAKQGRDALKIEWDDSAAE
KRSSDAIMAEYRQLAEQPGASARKDGDATQAIAGAAKKISATYTFPYLAHAPMEPLDAVV
KLTADSCEIWAGDQFQTVDQGNAARTAGLDPQQVKIHTLYAGGSFGRRANTRSDYIVEAV
SIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAGLTADGKLVGWRHRIVGQSILA
GTPFASVMVKNGIDSTSVEGAANVAYAIPNLSVELTTTQTGVPVLWWRVVGSSHTAFAVE
AFIDEAAHAAGKDPFAFRRDLLAHEPRMRGVLELAAQKAGWDPAKPLPKGRGRGIAVAEA
FKTFVAQVAEVSVDKDGNVKVERVVCAVDCGTPINPDVIAAQMEGGIGFGLGAALHSAIT
LKDGKVEQNNFDGYQVLRFAEMPKVEVHIVQSGEAPTGVGEPGVAPVGPAVANAIFAATG
RRIQSLPFPVAAEKSA
>A0A0K8P1Z3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MTTLNVNGRAQALDADPATPVLWALRDHLGLTGTKFGCGAALCGACTVHVDGQAVRSCVT
PVSAVAGRRVQTIEQVTGGKDRVGNAVHAAWVKHDVAQCGYCQSGQIMSATAFLKSLPKG
KQPSAAEIDAAMAGNLCRCGTYARIRAAVADAARALA
>A0A857JHG4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola mesophila|TrEMBL
MIRFNLNSKPVEIDVDPNMPLLWVLRDILGMTGTKFGCGMAQCGACTVHLDGQPIRSCVM
PLSAIADKDVNTIEGLSASAEHPVQQAWLEHNVPQCGYCQSGQIMSAVALLNEHPDPDDE
TIDSYMQGNICRCGTYPRIKAAIKTAAKNKQSAFDYSLGKEVGGQA
>A0A7Y9VYJ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVVGQNVTTIDNLHADPVGQIVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPYPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A4U9HK56|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MELNINNKIYQTDADADTPLLWVIRDDLAMTGTKYGCGLAQCGACAVMVDGQAVRSCVTP
LETVAGKKITTIEAIESDDVGQRVVAAWVKHQVPQCGYCQSGQVMAATALLKHNAHPSDE
EIAAAMVNLCRCGTYNAIGAAIHEVAGKGDKV
>B2AIQ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MNAKATTPSRGRRRFLLGALGLGGALVVGWGVMPPRSRLGGPAVFPEKSGQIALNGWIKI
TPEGNVILAMPRVEMGQGIHTALSMLAAEELDMPLTRVSIESSPIERIYGNVVTMGDSSL
PLHPDDADKTWARALHWIMAKSAREIGLIITGASSSVADGWQPVREAAATARASLVEAAA
REWGVRAAQVTVREGQLIGPGGKQMPFSAVARKARDIAPPSSVTLKPAAQYQLIGKPAPR
NDIAAKTDGSARFAIDARPPGMLYAAVVMCPVIGGKLKTFQSKAALAMPGVRYVVPFDGS
TGGAPGVAVVADHYWQARQALEKLEPVWDNGPHASLDSAEIRQQLVGALDSDKGGFTYRS
MGDGLKAFDKTGGATIVEAEYSVPYLAHAAMEPINCTAQVTRDGVQLWAPTQVATLAQLV
AARAAGVSRDQVQIDIPLIGGGFGRRLESDFIGQAVSIATRTEGRPVQVIWAREDDIRHD
FYRPQAIARLKARVENGKVTAIASRSAGQSILAGELERLFGVPSLGIDRYAAEGLFDLPY
EIEHEHIAHLVVDLPVPIGFWRSVGHSYTAFFLEGFLNDVAAAARLDPLAMRRDLLKAHP
RELKVLDTAAQAAGWNRPLAPAADGAPRARGLALHNSFGSMVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPDIVAQQMESGIIFGLTAALYSQIQIKDGRIVQTNFPDYPMMKMAQTPV
IETHLVPSTAEPSGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMV
>A0A5P9CEW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. THAF187a|TrEMBL
MITLNLNGKDHELDVADDMPLLWALRDVANLTGTKYGCGMALCGACTVNVEGQPTRSCVT
PVSAVVGKRISTIEAVAEDSVGKVVQEAWRELDVVQCGYCQSGQIMAATALLSSNKAPSD
ADIDAAMSGNICRCATYVRIRAAIHQAAEQLA
>A0A165UCH7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. Ad26|TrEMBL
MNVSSSRRGFLKGAAASAAAVLVIGVAPSGVMAAANSAETTMLNPFVKIAADGTVTAIAK
HFEMGQGPSTGLTTLIAEELGVSMDAIEYEFAPSNPKLYNNTAFGPVQGTGGSTAMFNSF
KQYRQAGAAAREVLLQAASLAWDVPAAQLKLEDGVISGGGNKAPIGEFVAAASKMTAPEN
PRLKDPSEFKLIGNANVRRKDTPPKINGTAKYAMDIQLDNQMVVTIKRATRKGATVTSFD
DSAAKPVKGFIRAATLPNKAGVAVYAENTWASLQAREALEVTWDNSAAESRSSEDVYKEL
MAAVNMEPEYNLTKNDQAEIAGAIKNAEKVVEETFYFPLLAHAPMEPLTCTIEATEDGGV
ILHDGCQMPTSPHAAIAQILQVPMDKVQVNTMFAGGSFGRRATPTVDYQVEAALAFVMTD
RRRPVKLVWSREDDITGGYYRPAFAHKVRVGLDADGNIAGWDHRVAGQSISKGTPFEAFS
VHDGVDHLSVEGVTPTPYSIPGMFAGLTDIKPATTVLWWRSVGHTHTAYVMEAMMDAVAT
AAGRDPVEFRLAHLAGDTPDQKRLTGVLKLAAEKGNWGKGAEGRSQGVAVHKSFGSYVAE
VVEISGDAENGVKIEKVTCAVDCGIPVNPDVIKAQMEGGIGYGLGHAMRDEITLENGEVV
QQNFPDYEPLRIGDIGEIETHIILSTEAPTGVGEPGTPPSAPALANAIAAKGPRVTELPM
TKAGVTFA
>A0A165PFL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. Ad26|TrEMBL
MSRLGKYTRRAFLGLGVAAAGGLAVGFYFYQKPYANPLDAKKAEGETPFNPYVMIDEDNT
ITIIAPRAEMGQGVHTTLAALVAEELEVPLEQVVVEHGPSSPAYFNAAMLEESTPFPFYD
ESVLAELARGSMKIVAKFLGLNMTGGSSSTTDAFVKMREAGYAAKFVLLKAAAEHFGTSE
DNLTLADGTITDKASGKSVTYGELASKAAAVSPPSEMKLKKASDWKILGKTQKRVELKDK
VTGGRIFGIDVQLPDMLYGTVRMAPRKGVSLKNYDKTATLAIPGVKDVVEIRTITGEGLG
VIADNTWAAFKGAEALEIEWDDPLSLQNSDQMWSALENALTQEATFELGGTGSDAEVFTS
IPESEAVSAQYRVPFLAHATMEPMNATAQHDGSTIRVWTGTQAPGLIQSVVSSHFDMDSA
NIDVTTTRLGGGFGRRLEVDFALYAAVIAKATAPNPVKVTWTREEDTQHDTYRPMAIGEF
KGQVTPDGTLKTMDMQVASPSIIQSVMPRIFPGISPAGPDNTVLDGAFNQPLDVENIRCQ
AHVADLQVPIGFWRSVGNSVNGFFHESFMDEAAHKAGKDPLEFRLAHLTSDEFRPAREAL
KRVAEMSGWGTSLPAGKGRGIAHVLSFGTWTAQVVQVDVTDNTVTIEEVWAVADPGIVLD
PGMFKDQIMSGINFGLSQALGQEITWVDGEVEQANFDTFDAMRMYQAPKITIELLENSPR
MGGAGEPGTPPSTPALANAIFAATGKRIRQMPLSNEIDFI
>A0A7Y9DSY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinomycetospora corticicola|TrEMBL
MPNHTFKLNGESVNVDVEDDVRLLWVIRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVGAVKPTDEVTTIEGLADTAPGGDLHPMQQAWIDNDVAQCGYCQPGQIMAAVAKVRQ
CQAEGREVDDAAIEELRNICRCGTYNRIREAIKAGAEKM
>D3P4L4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum sp. (strain B510)|TrEMBL
MNRLLTAPSPARTQSPNGYRIPLELQIAAQSAVPLMKPDGVSNLSRRAFLGFGTSALVLG
ALLPSMPVRAQTTATAAAAIKPGTRVPAFLVIGKDNAVTLLSPFVEGGQGISTGLAQIVG
EELDVDPGRFTVECAPPGADYGVINGLRMTGGSFSTRSSYPLMRRLGATARDMMIRAAAT
RLKVKPRSLSTEDGFVIHAASGRRLSYGELAPVALALPPRDDVALRDPSSFRYIRQPVAR
LDVRAKSTGKAVYAIDQKLEGMLYAAVRHAPNQGTTVQAIANRAAVAAMPGVHSVHTLPG
AVAVAADSWWRARRAVEALSVSWTAPASSGLDSVAADYGSDGLLAALKSSTEAGLPAETA
GDAAAAFAKAAKVIEAEYDAPYLIHGQLEPPSSMARFNPDGTLELWAPNQMPELFQSVAA
QAAGLPPDKVILHSPMLGGFFGRHFLYGSANPFLQAIQLAKGTGRPVKVLWSREEEFRMD
AVRPLSFTRFRAAIGADGRPTAIQARTVGEGPLGRWFGAVFKDPVDSSAVEGVTEKPYAI
PNRRMEYVKFPHPVTIAFWRSVGHSMNDFFYEGFLDEIALAGGQDPFALRMELLKDKPRH
RKLLETVAAMSGGWKRGPYEVDGARRARGVSMASPFGSETATIAEVSVEGGETRVHTVWV
AFDPGSIVNPAIVKSQVESAVALGLSATLFEELVYKDGVRQSHNFDDYPILSRRSMPAVH
VEIIESGAPMGGVGEPGLPGVPPAVVNAVAALTGQRIRSLPLAKSRIGV
>A0A5P9I8D1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. THAF9|TrEMBL
MTTFTLNGKETEIDASPDMPLLWALRDELKMTGTKYGCGVASCGACTVHIDGVPSRSCQT
YLGDLEGASITTIEGVENEAAKAIQEAWVELQVPQCGYCQSGQVMSASALLAETPKPTDE
DIDTAMDGNLCRCASYARIRKAIHRAAEIMEA
>A0A833J036|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MIQDFFPKTSAKLMAELAASQNDAGPVRLDNVSRRGILGGMGALVLALSLSDRAKADEGQ
TEEQKAKKFGADGMPNGWRDDPKVFVAIAKDGTVTVTNHRSEMGQGVRTSIAFTVADELE
ADWSKVKVVQAWGEETHFGNQDTDGSRSLRHFFQHFRHAGAAARLMLIQAAAKQWGVPAS
EVKAEGHVLTHAKSGRTLGYGDVAEAAASLPIPARESVQLKKPDAFRYIGKGKIGLIDNR
DITTGKAIYALDVKLDGMLYAVVARPAVYGGKVVSFDDTEAKKVPGVVKIVKIEGGEIPS
EFMPLGGIAVIAKNTWAAMKGREALKVTWDDGPNAGYDTDAFRKELEAAARKPGKVVRVA
GDVDAAMKTAKAKFEAEYFVPHLAQAPMEPPAAVARIKDGACEIWACTQGPQAAHDRVVK
RLNLPADKVRVNVTLLGGGFGRKSKPDYVVEAALCSQAVDGQPVKLVWTREDDIQHSYYH
TISVERIEAGVDDKGMPVAWLHRSVAPTIGSIFAPDPKHELPFELGMGLVNNPLALKNLR
FENPEASAHTRIGWFRSVSNIPHAFAIQSFVAELAHAAGRDPKDYLLELIGPARKIDPTE
IGDVWNYGEDPKRYPVDTGRLRRVIETVADGAKWGRKLEKGRGLGIAGHYSFVTYTAVAA
EVEVDDKGQVKVHAIDIAVDCGPQVNPERVRSQMEGAVVMGMGLALTSKITFKNGRAEQA
NYDGYEVLRIDAAPKVVRVHLVPSNDYNAPLGGVGEPGVPPVAPAIANAVFAATGRRVRE
LPLRDQLSS
>A0A381A3Q2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella pertussis|TrEMBL
MLAATRDFTLEVNASRHTVTADPDTPLLYILRNDLCLNGPKFGCGLGECGACAVLIDGVA
ARACTIPVRGAAGHAITTLEGLGTPQAPGPVQQAFIDEQAAQCGYCLNGMIIATQALLLR
NAAPTDEEIRHELQYHLCRCGTHIEIMAAVRRAARLWAARQA
>A0A5E4VYM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea pneumonica|TrEMBL
MRELRFNGLRLPLRPGVSIGDYAGVSRRAFLKTSAVAAGGLMLEMSWPGAVRSAHAEGPA
ATPVVPSAFVRIAPDDTVTIQVNRLDFGQGVQTALPMLVAEELDCDWAKVRSELAPAADV
YKDPLFGIQMTGGSGSVAHSWLQYRRIGASARAMLIAAAAQQWKVSPADLRTENGAVIGP
KGQRATFGSLAAKAQTMPVPADVKLKDPSTFRLLGKPTGRLDARAKSTGTPMYGMDFKLP
NLKVAVVARPPVFGAKVKTFDAKAAKAVKGVRDVLEIPDDRGGTAVTVIADGYWQAKTGR
DALNATWDTTGVEHVDTTAQLAKYKELAKTPGVVAIDADVSKLKGAPKTLVAEYSFPYLA
HAPMEPLNCTVQLSDKGAEVWTGTQFQTVDQAAIAHTLDLKPEQVKLHTLMAGGGFGRRA
VPTSDYGVEAAQVAKAWKRAGHREPVKVIWSREDDIHGGYYRPMYVHRAEIGLDAKGNVL
AWNHTIVGQSILQGTPFEKMMVKNGVDSTSVEGVAGTPYAVPLRLTLHSPQANVPVLWWR
SVGNTHTAYVMETLIDELAKNAGKDPVDYRYALMGDKHPRHRAALALAVERSGYGKTKLP
AGQAWGVAVHESFDSVVAYVVVAEVKNGTPRLVSATAGVHCNFAVNPLTVAAQVEGAALM
GLGTTLPGAAITLKDGQVEQSNFHQYMVARLTDMPAIGVHIVSSGDAPTGMGEPGLPPLA
PAYANAIFAVTGKRLRALPFDLTTA
>A0A6M8MUT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas graminis|TrEMBL
MSESQSSAAMLSRRGLLKGSALLGGLVIGTYLPASVTRSFAADLVQGASLGDNAEQGYGA
FVRIDHSGAVTLISPKIEMGQGVQTGIAMMVAEELEVPLSQITITEAPPNAALYTDALLS
FQATGGSTSTRYSWEPLRKAGAGARIVLIQAAAMRWKVAPSQCHAENGRVIGPNGQSAGY
GELVDAAAKLPLPTEIPLKAVSEFKLLGKPVQRLDTPNKVNGTAKFTIDLQVPGMLIAST
LTCPVHGGTLRGVKNEDAARKVPGVRDIVRLDNAVAVTASNFWSCQQALKALDIDWDLGP
HAALDSAQLDKSLFEASAGDGVFAHQSGDIAGALKNASSRFEAIYEQPFLSHSPLEPMTC
VAHVRADACELWVGCQAPGMAQAGAAKVCGMPVEKVVIHNQLIGGGFGRRLESDFIFQAV
DIARQLSYPIKLIWSREEDMTHDRYRPHYVDRLNAALDKDLRPVGWEHRIAGASVVAAYI
GALPADGVDGDAVEVAKDPIYTLPNLQVRYIRHDPEVIPVSWWRGVGPLRSTYAIESFID
ELAHNAKVDPVKYRLALMQSQPRAQAVLTKAAELVEWDKPLPAGSGRGVAVTAVFGSFVA
TIVELEKQGDKGLRIKRLVTAIDCGFATNPTSVASQMEGGTLFGLSAALFNEILIEKGQV
QQTNFHEYRQIRMSDAPPVEVHIVDSVETPGGVGETGAVPAAAALVNAVYAATGVRERRL
PLSRFGYFTV
>A0A839ZGR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Angulomicrobium tetraedrale|TrEMBL
MPLLWVLRDVLGMTGTKFGCGIAQCGACTVHLGGVAVRSCQLAVGDVGPQAITTIEGVGA
TPEGARIQKAWLDLEVIQCGYCQPGQILSAAALLAANPAPDDAAIDAAMAGNLCRCGTYV
RIREGIKHAARS
>A0A0S4TVL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MTADATAPRRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQAGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVRVERAPIERLYGNVVTVSDSAL
PLHPDDAGKAWARVLHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
RAWKVPAAQVSVHDGRLVGPGGRQAGFGEVAAHARDIAPPANVTLKPASQYRLVGQPAPR
SDVAGKIDGSARFAIDVRPPGLLYAAVAMCPVFGGRLKTFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLEPVWDSGPHATLDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVSGATVVEAEYSVPYLAHAALEPINCTAQVTQGHVRLWAPTQVATLAQLV
AARAAGVGREQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIERGRVTALASRSAGQSILAGELGRLFGAPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEVAAAAGLDPLAMRRDLLKAHP
RERTVLDTAARAAGWGQPLRPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPGIVAQQVESGVVFGLGAALHGQIQIKDGQVVQSNYPDYPVLGMADTPV
IETHLVPSTAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A7W6HGJ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantimonas endophytica|TrEMBL
MVSLIVNGLPVEITAQDDKPLLWALREDLGLFGAKYGCGVAQCGACRVLVDGVSTPSCAT
TLGDVAGASVITVEGLLGRDGTLSLVQQAWIDEQVPQCGYCQPGFLVAVTDLLARTPRPT
DAEIDEAITNICRCGTYLRIRRAIHRAAAAQAQG
>G7ZI18|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum lipoferum (strain 4B)|TrEMBL
MLHHLIRQAAQNGFGEPLALKPLTAPSRRGFLKAIGAGAGALVVGAHLPLPALAAEAAAK
TIGPADPRPQLFVIVAPDNTVTVLAKHLDKGQGIVTGLATIVAEELDADWAQVRGAFAPA
DSKLYANHFFGIQGTGGSTAIANSWDELRMAGAAARAMLVAAAAVRWSVPAGEVTVSKGV
VRHAASNRSLTFGELAEEAAKLPVPQQVKLKDPKDYVLIGKPDLHRLDHISKTDGTAIFA
MDIRRPGQVTAVLARSPRFGGTVKSVDDTAARKVPGVIEVVSLPVGVAVIARNSWAAMKG
REALTVTWDDAKSEMRGSDAMLADYRKLADRPGAVAAGKGDADKAFADAAAKGGHVVEGD
FVFPYLAHAPMEPLNAVVALNPEGGCTIWAGSQFQTVEQMVAAHILGCKPEQVKIETQWA
GGSFGRRATTNADYIAEAVMIAKAYPKAPVHLVWTREDDIKGGRYRPLFLHRIKAAVDAK
GALVAWKQRIVGQSFMAGTPFEAVMVKNGVDATMVEGASDMAYAVPNLAVDAHTVASPVT
TLWWRSVGHTHTAYSKEVMIDRLAKAAGKDPVAFRLEMLKDHPRLAGVLKLAAEKAGWGQ
PMPQGKGRGVAVHESFNTYVAHVADVTVDAKGQVKVDRVIVAIDCGQVINPDIVKAQMEG
GTGWGIGHALRGEITMTDGVVDQANFDSYLPMRMSDMPVVEVHIVPSGERPTGAGEPGVP
TAAPAVANAVFSVTGQPQQTLPFSRSGIVS
>H0SJH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MNGRDHEVAVEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPLDSV
GKAEIRTIESIEQDGVGRKVVEAWVADQVPQCGYCQSGQVMAATALLTQNPKPSESDIAD
AMTNLCRCGTYNRIAAAIRRAAQA
>A0A221V024|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arenibacter algicola|TrEMBL
MANFNLKINGKTEQLDVDPTTPMLWVLRDHLKLVGTKYGCGISQCGACTIHLDDNAVRSC
QLPISAVGDQNITTIEGLSENGDHPVQLAWMEEDVYQCGYCQAGQIMNASAFLKKNPNPT
DEEIEGAMNGNICRCGTYTRIKKAIKTAADSKIA
>A0A1Y5SAT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria litorea R37|TrEMBL
MATTLTINGKTHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHINGEAVRSCQ
TPLSDVDGPVTTIEGIGTPDSLAAIQQAWVENQVAQCGYCQSGQIMQAASLLAENPSPTD
TDIDEAMQGNLCRCGTYPRIRAAIHDAASKMKEA
>A0A1Y5SA81|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria litorea R37|TrEMBL
MGIGKILRRTFLIGSAAIVGGVAFGTYYVTRPAANPLEPREGEAALNPFVLIDQNGITLF
APRAEMGQGVKTSWAALIAEELDVELEQVNVLHGPAAAAYYNSAFVADGLPGKGYDTSQF
KHNVGEALGVLGRALSLHGTGGSTSMKDGFVRMREAGASARETIKQAAADRLGVSRDDLK
TEAGHVIAPDGTTIPYSDLAEATAALDPIEAPLRDPSEWRILGRSQPRLDMVGKSTGTAE
FAIDVRLPGMKFATVRRNPKLGGGMKSFDASAAESMPGVEKIISVDDGIAVIGTNTWLVI
QAAEAVEIDWEDAPYPPTTDAVFAQIEKAFDDAPNSTMRDDGDVDTAVEGATEISANYTA
PYLAHSTMEPMTAAAHLTGDGLQVWTGTQMPVFAQQRAAYVAGLDSEQVEMNTTYLGGGF
GRRLELDFVEVAVKVAMAMPGTPVLTTWSREEDMRHDYFRPGAMARLRGAVKDGKAVLID
GHVAAQSPVQQAVERLTGMAGGGPDKVLVEGFFNQPYAVPNYRMSGYIADLQIPVGFWRS
VGNSYNGFFHETFMDELAHVAGRDPLDFRLDHARDEWDVAARCLEKVRDMSDWTGKTPDG
VGRGVAMTYSFGTPVAQVIEVVDEDGTIRINKAWIACDMGLAIDPHVVRAQMFSGLIYGL
SAACFGEITFDEGEVEQWNFPDYDALRMHTAPKVEIEILETNRFMGGAGEPGTPPSMPAL
GNALFDLTGKRARSLPLSHEFDLLI
>A0A7W5A4E2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides albus|TrEMBL
MTEIQEDIGTEPSIGRHSVGRRRFLGYLIGGTTVVAAAELGLLSGQAAAKIPSAPQVFDA
YDLSDLLTHAAQPTSSLITVTINEDGTASFALPRAEVGQGITTAAAMIIAEELDLPLKKI
DVTLAPARPELIWNQITGGSNTIHAMYTPIRVAAAVAKKTLLEAAAAQLGGVVDELETRD
GVITDALGNSLTYGELTAQAASPDTKAVEVGLKDEATFTLLGKPTNRIDALDAVTGKKVY
TTDLDVKGALPTMVCRAPTLNGKPTKVLNAAEVKAMPGVTHVAMVPTGVAVRARTFGQCI
DGVRALRVDWEDGPVVGESDQDILSGVKAAELPMPALPNTPLAKTIAYDFTFWFRSNSPM
DTNSAIADVRSDRAEIWSGLKNPIVTQQQIALELGLTPDKVKVNVMQAGGSFGRRLFFDG
AMEAAQVSKAMGVPVKLMWHRSDDARVGRAHPLATSRVRAMHAAGEVLAFQQSHTAVEMD
LRHGFGEIVTALAADLPAGLGNLGYAQTIFALTTGIPYDFGVLLQTLNETDTRFNTGAMR
NVYSPDVRTANELVVDQLAKAMRKDPLAFRLEFCRNERVRGVLKKAREVAQWGKPMPAGT
AQGIAVHTEYKGASACVVEIDCRPETVGRRVRDAVTGPRVMKATMVTDVGQVINPRGVEA
QMQGAINDGIAMTLTSSLHLVDGHFEEASWDNYFYTRQWNTPPEIEVVIMDSAEPPGGVG
EAGVAPTAAAVACAYARATGKVPTEFPINHRDPLAFEPKPRTPPIPPSPTDGLRWTY
>A0A1Y5TE35|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria litorea R37|TrEMBL
MTLNLKLNGQTHQVEAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLDGEPVRSCQ
TYIEDVEDAEITTIEIVDQNPVGAAVQEAWAELDVVQCGYCQSGQIMSAIGLLSENSKPT
LEEIDDYMNGNACRCATYQRIRAAIVLASEKLEA
>A0A1X6ZML3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius albus|TrEMBL
MTVQTTRRNFLRGGAATAAVLIIGSRPDGAVAAASGDKAMFNPFVKIDAEGTVTAIIKHF
EKGQGPATGLSTLIAEEIGLRMDQIEYEFAPSNPKIYNNLAFGPFQGTGGSTAMANSYQQ
YRTAGAAAREMLIIAAAQSWGVEASTLSIEEGMVTGAEQSAPLGEFVAAASSLEAPAAPR
LKDPSEFRLIGNAEVRRVDSVIKGNGTAQFAMDVHLPNQMVAMIARPEQRGGLVRSFDDN
GSKEVMGYINAATLPNNAGVAVYAETTWAAMQARDALEVEWDLDAAEARSSDEIHSEIMA
ALEAEPQYNVSKTDLAATQSAIGDAAQVVEQAFYFPLLAHAPMEPLNCTIEATADGGVIL
HDGAQMPTGPHFALSQILGLPMEKIQINTMLAGGSFGRRATPDADYQTEAALAFSMTDRS
RPVKLVWSREDDLRSGYYRPAFGHKVRVGLDADGAIVGWEHRIAGQSVIKGTPFEAMIVH
EGIDHSSVEGTADTAYDIPNGFFGLTDTPKATTTLWWRSVGHTHTAFVMEVMMDMAAKAA
GQDPIEYRLGYLTGGTKDQQRLAAVLKLAAEKAGWGNVAEGRAQGIAVHKSFGSYVAEVV
EISGNADSGVKIENVTCVVDCGLPVNPDVIKAQMEGGIGYGIGHVMRDQITLTGGAVDQY
NFPDYEPLRISDIAAIDVHIVPSAEAPTGVGEPGVPPAAPALANAIAAASAELRVSAMPM
VENCVDFV
>A0A7W6CY21|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hansschlegelia beijingensis|TrEMBL
MSIQDRIRGGAPLDMSRRGFLAIAGGAGVGLMVGLKPLPAEAEAAGGVVQFNPFVKVAPD
GAITVVVKHLDMGQGPTTGLATLIAEEMDADWSQMRTEFAPADANLYANLVFKAQGTGGS
TAMANSWEQYRTAGAAARAALVKAAADKWQVAQGEIVVDKGVLSHPSGKRGTYGEFAEAA
AKLPAPIGAPQETPYKDAAKFKLIGKEGLHRIDNDPKTDGTAIYTQDVKLPGMLVAAVAH
PPRFGGKVKSFDDSEARKVKGVEKVVQIPQGVAVLARNTWAAFKGRDALKVEWDDSGAEM
RGSEQMLKEAREAVSKPGAAVATNKGAVAAGFEGAAKVVEAEYTFPYLAHAAMEPLNCVA
QIKDGAVKLTFGSQFQSIDQPTAAAIAGVTPDKVTIETVWAGGSFGRRAVPTADYVAEAV
AIAKASGGDAPVKLVWTRDDDTKGGYYRPFYAHRVRAAIGADGMPVAWEHRIAGQSIFAG
TALEAMAVKDGVDETSVEGASNLAYAVPNLRVELTTLKAGVPVLWWRSVGHTHTAHVVET
MIDELAHAAGKDPVEYRLALLKDKPRHLAALKLAAEKAGWAPGSKPEKGKGRGVAVHESF
NTIVAEVVDVTITKDGGVKVDRVVAGVECGTVINPDVVRAQVEGGVGFGLGAALRNAITL
EDGVVQQANFDTYEPLRMSDMPKVEVYTVPSDAKPTGIGEPGVPPLAPALANAIFSATGK
RVRDLPLGDQKFTTA
>K9NJZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. UW4|TrEMBL
MLTLNINGQDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSADGSHPVQKAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAELG
>K9NPZ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. UW4|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVSTIDNLHADPIGKVVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A375EMD6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEARADAGVATLDRRSFLKLTGLAGGGLALGVAPLAQAQEGAK
PKAPPAPPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVIS
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTRL
KGMVVAVVARPPRFGGKVKSFSADKARAVQGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALELQWEDAGSKVSSQALFDEYAKLAGQPGTVARAGEGDIAAAIQRAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVAAGHSEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAASKQDPVAFRLARLDEKKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFNTVVAYVVDVSVVKGEPRVHRVTAGVHANRVVNPMSAE
AQIQGSCVFGLAMTKPGFAIELENGAVKNSNFADYPPPRITDAPVVDVFFVPSQENPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A375FM16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDGGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLGQVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAALRLGVDAAALEAENGVFRVRGTQASIGYAALV
AGEHVELPLADDVPTKPVESYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGACVGTSLLSVDRESVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
KPVPPLPALDDPEPALRANPATRRELLTEGKLPAAGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAARADPVDFRLRHLPDERAADLLRAVADAAGWQRGAAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLTVDAATGSITIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQALSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVVLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMASKKG
>S2DJ57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)|TrEMBL
MNAGGLVEPPLYADRFPPGAIENYLAEEWIVASNITVGSSRAPRSNFIASAEQSFLDELA
EELGKDPIDFRLEMLKRAKENPVGKNNDYDPERYAGVLKLVREKAIWKGIGIRNYQDVIL
EV
>A0A3G7YC73|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R5-89-07|TrEMBL
MITLDINGRTHELDIAPDMPLLYALRNQVGLNGAKYGCGLGQCGACTVLVNDKPVFSCLM
PCGALAGKSVRTVESLGSEDQPGPLQKAFIDEQAAQCGYCIAGMIVRAQALLEANPHPDD
ETIRRHMAPNLCRCGTHVRILAAIKSVVAQGGKV
>A0A4P8HR32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MKLNVNGQVREFQAEDDTPLLWVLREQLGLTGTKYGCGIAQCGACTVHIDGEAMRSCVRP
VSTVTEQMKIVTIEGLSPDGSHPVQKAWAALDVPQCGFCQSGMIMAATALLKEKPKPTDA
DIDTAMTNICRCGTYNRVRKAIHVVARGGDAKSAGLAIEHREGSKA
>A0A4P8HVB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MREKKPDAGPVEKLSGSAIGRRRFLRVGAAAGGGLLVGFVLPGCNRKESDRQEAPPEKAV
GHAATAVSEVAPGLAPNAFIRIDREGLVTLIMHKVEMGQGTYTSIPMLIAEELGVDLAKV
KLEHAPADNNLYSDPLLGGQVTGGSTSIRGAWKPLREAGAAARAVLVQAAAQTWNVDPGT
LRVANGAVTNGAGKTLHYGELVDAAAKLDAPKAVALKDPGSYTLIGKNHARLDSAPKVDG
SAQFGIDVKLPNMGIAAVAACPVIGGKLIASNDPKALAIPGVREVLKIGSAVAVVATNMW
AAKQGLAALAPQWDFGANANVSTASIVADMMEKSKAAGAVAADEGNALKELEGDGKAGRK
IEAVYEAPFLAHATMEPMNCAVDLRADGCDLYCGTQVPSLAQGAAAKLTGLPLEKVKVHN
FYLGGGFGRRLEVDYVTQAVAFAKAQAKPGPVKFVWTREEDIQHDMYRPYYVDRIAARLD
DKGRPQAWFHRVTGSSIMARFAPPAVKNGVDPDAVEGAADLQYTIPALRVEYLRHEPPVP
TAFWRGVGPTHNVFVVESFIDELAHAAKQDPVAYRRALLDKSPRLLGVLNLAALKAGWGK
PMKPVAGRKVGRGVSAQFAFGSYMVQIAEVSVGPEGDVTVHRVVCALDCGQPVNPDGIVA
QMEGGIVFGLTAALWGEITLDGGKVVQTNFGDYRMMRMNEAPKVEVHIVASKDEPGGIGE
PGTSGIAPALCNAIFAATGQRIRKLPVSASLKKA
>A0A1L5PG27|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli 8C-3|TrEMBL
MVTFTLNGQTKTFDGDPDTPLLWFIRDFEKLTGTKYGCGVAQCGACTVHMDGFTRRSCIT
PISAAEGSEIFTIEGVEGKEAEVVRAAWVAIDVPQCGYCQSGQIMSAVSLLQNIPKPTDE
DIDGAMAGNICRCATYHRIRQAIHNAAAAMEG
>A0A1L5P713|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli 8C-3|TrEMBL
MSYDLSVNGKHYAVDVDGDIPLLWVLRDTIGLTGTKFGCGIALCGACTVHVDGVPVRSCV
MPVADAAAKPITTIEAIGETDEGARVQKAWLDIDVVQCGYCQSGQIMSATALLAANPSPT
DDDIDAVMAGNVCRCGTYPRIRAAIKLAAKAR
>A0A846VIL0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. SG609|TrEMBL
MIVLNINGESRSVDVPDDMPLLWVLRDVIGLTGTKFGCGIAQCGACTVHLDGAAVRSCVL
PVSAVGSKAVTTIEGVGASAVGKKVQQAWLDIEVVQCGYCQSGQIMSATALLAATPEPSD
AEIDVAMSGNICRCGTYVRIREAIKQVATGQKVAPQTIPNVAPTASPAAAAAALLSFVRV
EDMA
>A0A0N0E417|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fuscovaginae|TrEMBL
MTFNDAGVPMITLKLNGQDHPLDVTEDMPLLWAIRDVAGYTGTKFGCGMGLCGACTVHID
GLAARSCVTPIGSVVGRDVRTIDNLHSDPVGQAVQQAWLDGGVAQCGFCQGGQIMSATAL
LKVNPKPSDEQIEEAMLGNICRCGTYNRIKTAIQAASAHLQEAKA
>A0A3G7JHT2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MITASRRGFLKGGALLGGGLVVAFVIPGANRFARAASEEFVPNAFLRIAPDGMVTVVLGH
SEMGQGIWTGLSMLIAEELDADWSKIRVEHAPAAAVYGLPAFGGMQITGGSTSTWMEFDR
YRQAGAAARQMLIEAAAKRLQVAPSTLHTEQGWVVAGDQRLSYGDLANDAGQLPVPDPAS
LHLKEAKDWRLIGKPTKRLDTPEKITGRAQFGMDMYFDGLLTAVVLRSPVFGGTLKSFDP
QAALAVPGVIKVLQVPTGVAVVAEHYWAAKQGRDALKAEWDLGPNANMSSESLMQSFRKL
ALTPGTKVAEAGDAAGTMAKATQVIKAEYSVPYLAHAPMEPLNCTVRIGADKCEIWTGTQ
FQTLDQMVASKITGLKPEQVQIHTQFLGGGFGRRANPTSDFVSEAVEVAKAAAAPVKTVW
SREDDVRGGYFRSAFLHQAQVGLDAQGLPLAWQHVLVGQSIMAGTSFEASFVKNGIDNTS
VEGLADGPYLKGTPNHRVDLHSPMTGITVLWMRSVGHTHTAFVVESLIDEMADAIGKDPV
EYRRILLKDHPRHLGVLNLAVEKAGWGKPMPNGHALGVAVHESFGSYVAQVVEVSLEAEQ
IRVHRVVCAVDCGIAVNPQSIVAQMESGITFGLGMALHSRISFKDGRVVQSNYHDFQVLR
LNEMPRVEVHIVASTDKPGGIGETGVPPTAPAVANAVFALTGQRLRELPLQLAGV
>A0A1K0JI35|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator|TrEMBL
MISFQLNGKTQQVDVPGDTPVLWVLRDTLGLTGTKFGCGIAVCGACTVHVDGQQRRACVT
PVSSIAGRQLTTIEGIGEDRVGRAVEEAWVRNDVTQCGYCQSGQVMSAVALLKVNRRPTD
ADIEQAMSANLCRCGTYARIHAAVKDAAKAIG
>A0A1Y6KJG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MNQHVTPRLNRRSFVIGTAAIGGGLALGLDLPFGGPQVVRAADGSPEVNAWVVIRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELACDWSKVTTEYPTPGQNVARKRVWGDFSTGGSRGI
RSSQDYVRKGGAAARMMLIQAAADEWKVPVAECTAANSVITHKASGKTTTYGKVAEAAAK
LSPPADVKLKDPKDWTLIGKGVKRLDTADKVTGAMVYGADLKLPNMLNAAIKDCPVTGGK
LKSYDEAKIAAMKGVKKVVAVDGTAVAVVADTWWHAKTALDALPIVWDEGPNAKVSSESI
GKWLAEGLDSGPAFVGNENGDAKAALASAVKKVEAIYNYPYQNHATMEPMNATALYTPER
CEVWCGTQNGEAAFAAVLEASGLPADKCEVHKLILGGGFGRRGQTDYVRQAVQIAKAMPG
TPVKLLWSREEDMTHGRYHPITQCKLTGGFDADNNLTALHMRISGQSILFSLRPDALVNG
KDPATFQGLAPSGEATIGYSVPNLLIEHSMRNPHINPGFWRGVNVNQNAIYLECFMDELA
NAVGQDPLEFRRKLMAKNPKHLAVLNAVAEKIGWGTPAPEGVYRGLAQLHGYGSYVAGAA
EISVIDGTKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGRIEQT
NFDTYNSMRIAEMPKVESIMIPSGGFWGGVGEPTIGVAAPAVLNAFFAATGKRIRSVPLR
DQNITFA
>A0A239S9X0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea sputorum|TrEMBL
MRELRFSQRPGVAVGDFTGVSRRGFLKTSAIAAGGLMLEMSLPGMMRTASAQGAAPAAVV
PSAFVHIAPDDTVTIQVNRLDFGQGVQTALPMLVAEELDCDWSKVRSELAPAADVYKDPM
FGIQMTGGSGSIAHSWMQYRRIGASARAMLIAAAAQQWKVPADQLRTEKGVVLGPNGKRA
TYGSLAAKAQAMPVPANVALKDPSAFRLLGKPTGRLDAKAKSTGTPMYGMDFKLPNLKVA
VVARPPVFGAKVKTFDAKAAKAVKGVRDVLEIPDDRGGTAVAVIADGYWQAKTGRDALKA
EWDTSGVEHVDTTAQLAKYKEMAKTPGTVAIDADVSKLKGAPKTLVAEYSFPYLAHAPME
PLNCTVQISGKGAEVWTGTQFQTVDQAAIARTLDLKPEQVKLHTLMAGGGFGRRAVPTSD
YGVEAAQVAKAWHGAGHREPVKVIWSREDDIHGGYYRPMYVHRAEIGLDAKGNVLAWNHT
IVGQSILAGTPFEKMMVKNGIDGTSVEGVSGTPYAVPLRLTLHSPKVNVPVLWWRSVGNT
HTAFVMETLIDELAKNAGQDPVAYRYALLGDKHPRHRDALALAVERSGYGKTKLPAGQAW
GVAVHESFDSVVAYVVVAEMRNGAPRLVSATAGVHCNFAVNPLTVAAQVEGAALMGLGTT
LPGAAITMKDGEVEQSNFHQYTVARLTDMPAINVHVVSSGDAPTGMGEPGLPPLAPAYAN
AVFALTGKRQRALPFEVASA
>A0A239SDE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea sputorum|TrEMBL
MAVSNTVAGPVTLSVNGERHTAAEAAPDTPLLYVLRNDLLLNGPKYGCGLGQCGACTVLV
DGQPTRSCVVPVSIAREREITTLEGLGRIGDLHPIQRAFIDEQAAQCGYCLNGMIMSAKA
LLDRNPTPSDSEIHAALRFNLCRCGTHYEIVKAVHRAAQYLQNGTDR
>A0A0P0RGV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caribensis MBA4|TrEMBL
MLKLNINGKTVEVHSDPATPLLWVLRCELKMTGTKFGCGVGVCGACTVHVGKEAKTSCQE
KLSDIGGNRITTIEGLQGTQARALKEAWTHVDVVQCGYCQSAQLMAASALIQRNPTPSRK
EIDCAMHGIICRCGTYPRIRQAILEATGQGKLT
>A0A0P7W4Y4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium HLUCCO07|TrEMBL
MGKVGKIARRTFLIGSAAVLGGVAFGYVMYQRPAKNPLLDGLGEGEAALTPYVLINGEGV
TLITPRGDKGQGAYHVQAALIAEELDVDLEKVNVDPGPPSGAYYNTALSAEAVPFAYYDE
GFMAETLRDVMDAPMKFLGMQITGGSTTVPDAWEKLRVAGAVARETLKAAAAEVSGINVT
ALDTGSGRVILPDGRELAYEELAPVAAGLEPVTKVRLREPEEWRYIGKPMKRIDIVAKST
GAQEYGIDVERPDMVHAAVRLNPRRGGALNGYDAQAAEEMRGVEAVFDIPGGVAVLADNT
WRAFRAAEAVECDWGPADHPGEQAEHWQALADSFVSDRRDSRQRDEGDVESALGDAPIEA
EYRAPYLAHAPLEPVNATVWVQEGRVDVWTGTQVPRFAQSHVAEICGVDAEQVHVHVLMM
GGSFGHRLEDDVVIRAAQIAMQAGGRPVKLTYSREEDTRQDFLRPVGMARMKGAITDGRV
RALDYHVAAPSIMASQMGERQGLPMPGPDSTIVQAAWDQAYAIPDCRVTGYRAPRLAPVS
SWRSVGASINGFFHEGFLDELIHAAGADPLEERLRLCFHEPTRKVLEAVGEMAAWSGPRP
EEGVGRGVALVTSFGVPCAEIVEVRQTEAGLRIERVWVAAEVGRLVDPVNFDGLVKGGAV
FGLGHAMTGEITFADGRVEQENFDLFKAMRIDQCPEIEVRGLENGDRVLGIGEPPVPPAA
PALANAIFAATGQRLREMPFAKFVDFA
>A0A090WPN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algibacter lectus|TrEMBL
MPMSGTDKVVVIGKTTWDAMKGKKAIKAVWKTETALESSETHDKVLLDLLEGNKFNTRRQ
DGNVKHAFANADKVLERVYESPFLPHNCMEPMNFFANVSPEKVRLVGPVQTPEAAAQVVA
DLLERDLEDVSIDMTRMGGGFGRRLYGDFVYEAAEISNAIQKPIKLVSSREDDMTMGVYR
PSSKYKISASIKNGKITGYHLKEASINGNMYGLIPNFFPAGAIENYQVDTANYKSNITTG
AWRAPYTNFLASAEQSFFDELAEELGIDRVQMHMNLLDNVKNNPDANIEYSPERLQGVLQ
LAIEKSNWG
>A0A1Q8JEN3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae356_Ps1|TrEMBL
MSTQTFKLNGETVTVEVEDDVRLLWVLRDVLGVTGPKYGCGINVCKACTSHVNGKAFNPC
ATPVGSLEEGDEITTIEGLADGDTLHPMQEAWIEYDVAQCGYCQPGQIMAAVALVKRAQA
EGFSIDDEALDEIRNICRCGTYNRIREAIKAGADNM
>A0A0P1I2Y5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria denitrificans|TrEMBL
MATTLKINGNQHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VSLSDVWGDVITIEGIGTPDTMATIQQAWVDHQVAQCGYCQSGQIMQAAALLAENPAPSD
ADIDEAMQGNLCRCGTYPRIRAAIHDAAGKLKEA
>A0A1M4EBQ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea gerenzanensis|TrEMBL
MPEHTFRVNGEQVTVNVADDVRLLWVLRDLLRITGPKYGCGINVCKACTSYLNGKAVNPC
AIPVKDLQPDDEVTTIEGLPATVGADLHPMQQAWLDHDVAQCGYCQPGQIMAAVALVERV
AAEGRTITDADLDGIRNICRCGTYFRIREAIRAGARNM
>A0A6T9XZ05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alteromonas macleodii|TrEMBL
MMKLYIDGEQHTVDVEENMPLLWVLRDVLNKKGTKFGCGMGLCGACTVHVNGEAVRSCIT
PVGVVEGSAIATIESVSKEGQEHAIQISWREYNVPQCGYCQSGQIMSALSMLNHIPSPSD
ADIDAFMSGNICRCGTYPRIKAAIKHASKLMQSNQAGDKK
>A0A0L6CVW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius tolerans|TrEMBL
MVKIILNGTETEVGDDPSMPLLWAIRDLAGATGTKYGCGVGLCGACTVHVDGKAERSCQV
TVGDAEGREVTSIEGLDPSGDHRLQAAWRELNVPQCGFCQAGQIMQAASLLAENPKPTDD
EILSAMSNNVCRCGCYQRIVAAVRLASTGS
>A0A0H3KNV3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MRHDRTAPMPPIDDAPRRRFLKQSAALLTAGVAVGFRLADATAAGPRASGDPHPAAGEFE
PNAWVRVLPDDTIKLVVHKHDSGTGTRTALAALVAEELDVDPFRVEVITPEDPFFADYIH
PLWKVFSTGGSTSVAMEYDRLREAGATARAMLVAAAARQWNVRASTCTTADGAVQHAASG
RRATYGSLASAAARLPAPQRVALKDPAQFRYIGKLRRKRGAAQKADGSFPYSIDVSLPGM
LVAVVTRAPVIDARVRSVDAKAALAMPGVRDVLQIPPRPDVLGGNQAGVAVLADDYWSAH
RAQAALKIEWEDSLFETFDSSTLAARQAAWVDDPAARVVPTIRDGDPANASLAGARTVDA
TYAMPYKAANPLEPINVTVWARDGGIEYWGGLQVPSTAMEAAQVIGGIPAHRVTLHERVS
GGSFGARESKYWLFEATWLAVKTGKPVKLMNSREDEMRALFYHAASCHRARAVLDARGNL
ASLWLRGVMPASPQQWEPGYLERADRMDFSTTEALTKWEFAYAAPHRDIGWIRLETGVPT
GWYRAVSYIPNVFAVESLMDEAAHAAARDPVEFRLAHMRDRPRHAAVLREAATRAGWGQP
LPAGVALGIATNQAYDSYVAVVARVVRDAEGAVRVAKLTCVADCGIAVSPAGVEEQLYGG
LMWGLGHATSDRIDIRNGRVQQSNFDTYRVMRMNDMPETDIHIVQGDRAKPGGVGELSSP
AVTPAIANAVFRLSGKRLRETPFDLSAVS
>A0A1Y0UWG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ascendens|TrEMBL
MPTLVINGQPHSVDVDADTPLLWVLRDILGLNAAKFGCGIAQCGACTVYVDGKAVRACNL
PVGLVGERAITTPEGLDMADPIVQAIKSAWVELDVVQCGYCQPGQVMAAVALLRTTPNPT
DEQIDSAMSGNMCRCGTYMRIRAAIHQAAGELA
>A0A6I8LQ72|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis camponoti|TrEMBL
MPNQTFKVNGRVVTVDADDDLRLLWVLRDLLGITGPKYGCGLDVCKACTSHINGKAFNPC
SVRVADIKETDEITTIEGLPATVGKDLHPMQQAWLDRDVAQCGYCQPGQIMAAVAKVRQA
QAAGRDITDADLDEIRNICRCGTYARIREAVKAGAKNM
>A0A5P9BI76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Vibrio sp. THAF190c|TrEMBL
MRLMSLSMATQEVATSRRDFLKLIGGVGAGLTLGVSITNQKAFASEQSASDVSFEPNAFV
RIGSDNTVTVMIKHVEMGQGTYTGLTTLVAEELDAAWEQMVPEGAPADASRYNNTLWGPM
QGTGGSTAIANSYMQLRTAGAVAKSMLVAAAAKKWGVNADEIVVSSGVVSHGNKQASFGD
LAEEAAKMPVPDPSTVSLKSPDDFTLIGKTKLSRKDIGKNNGTAIFTQDFKLPDMLTAMV
LHAPKFGATLKSVDSKSAKASPGVVDVITIPTGVAVLATDYWSAKKGRDLLVASWDESKA
FKKSSVQIMEEYTELSKKPGLPARIDGDAVKALESSDVVIDNTYEFPFLAHATMEPMNCV
AQVSDDACTVWNGEQLQTVDQMNIANLLGIKPEQVTINMLLAGGSFGRRANPRSDYLLET
VEIAKQKKGTPIKLVWSREDDTRAGYFRPAYVHRVKAGLDADGNINAWQQHIVGQSILHG
TAFEAFMVKDGIDATSVEGASNNPYDIANLSLELTTVKEGPTVQWWRSVGSTHTAFAVET
MIDELAVKAGKDPVEYRMKLLQKHPRWQGVLKLAAEKAGWGKSLPEGSALGVAVHESFAT
YVAQVAQVSMKNGMLSVDKVVCAVDCGVAINPDVIKAQMEGSVGFGLSPTLMSTITLDGG
GAVNQSNFHDYQVLRINQMPEVEVHIVPSAEAPTGVGEPGVPPVAPAVANAFAALTGNRQ
HVLPLNLKG
>A0A1S1HAV8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas haloaromaticamans|TrEMBL
MAISRRNFLVGGGAGAGLLLAWGLWPRSYRPNLVASPGEAIFNAFLKIGEDGHVAVVVPQ
AEMGQGVWTSLPQVLADELGADWRTIAVEPAPISPLYANDFLIGEAAQGMLPDLLKGVGG
WAARQYAIRSALMVTGGSSSIRGFETRFREAGAVARALLCTAAAKRWDADWRACDTAAGF
VTRGEDRLRFGELAAEAASLDAPGGVALRAPGAGGLSGRSVPRIDLPSKVDGSARYAGDV
RLPDMVFAAVRHGPHGATRLTGVDKAAAEKVPGVIAVVQNPGWAGAVATNGWAAERALDA
MRPRFTTDGPFPDSDSIDQALNAALDGGEATRFVAIGDVDAAFVGKQGLKVDYSVPLAVH
AAMEPLAATARLIGDRMEVWMPTQAPGLARAAVARALDMSEGQVTIYPMLVGGGFGRKIE
NDAAVQAAIIAREVRRPVQLTWSRRDDIQQDRFRPAARARMAAALGERGEVVGWQARIAA
PAAMASMQSRLMAGGGDPGAKAELSAVEGALPPYAIPAIAIDHLPVDIGIPTGIWRSVAN
SYTAFFTECFIDELARSAGIEPLSFRMQMLGGNPRLAHCLTTVTAMGGWDGGMPGGNQGL
ACHSSFGSHVAMLVEAHVGEDQRIVVDRVAAAVDCGRIIHPDIVLQQIEGGIVWGLAAAF
GATTGFARGMAEARNFDALNLPLLAGTPDIRVELIPSKEAPGGVGEIAVPPVAPAVANAI
FAATGQRLRSLPLAIGGQ
>A0A7W6G6B1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MSAVIDRRGFMAASLVGAGALAFEARIALAQDPGAVPLNAFIRIGADNKVTIGSKNPEIG
QGIRTMLPMLIAEELDLSWDQVVIEPTLANDKIYGVQSAGGSNSTPNNWLPMRQVGAAAR
AMILSAAAKEWGVDASSLTTAVGKVSHAASGRSAPYAAFARGAATETAPDLAKVALKDPS
RFTIIGQSKIGVDTVAITRGKPLFGIDVDMPGLIHGAIIKAPAHGATIASHDAGAALKRK
GVIAVVPVNSNSVAPGKFDTLVVVADSWWTAKNAREAVKVTWNDAAQQGFSTQAYDKGAA
EALAAGPQIAHAKNGDVAKALAGAAKTITADYSYPFLAHGTLEPQNCTGRWVDGKLEIWA
PSQAPNNGRSDTAAMLGIKGEDITIHQTRIGGGFGRRLINDYMVMAGQVAKALPGRPVKI
LFDRTDDLRHDYYRPAGWHRFTAGLDAKGDLVAFRDHFVSFGKDGKPIRAAEMSPFEFPV
NVLADSEIGITYLPTNLATGWLRAPTSNAVSFVYQSFMDEIAQAAGIDLPELMRRTLGAP
RDLAVVPGRPVLHSGRARAVIDGVCKMAGWQGGKLAPGPKGEKRGRGFGFYFSHRGYFAE
VVDITITDGANVRVDKVWACGDIGSQIINPINARHQVQGAVNEGLGQGMVEQKIEQVKGV
VQAESFGDFPLIRIEQVPREIAVQFLKTDYPPTGLGEPSLPPVIPALANAIFAATGQRLR
QLPLKLA
>A0A7W6WAI1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseospira visakhapatnamensis|TrEMBL
MVRLVINGSAQNVAVDEDMPLLWVLRDTLGLTGTKYGCGLSQCGACTVHVNGRAVRACQT
FAADLDGATITTIEGLAGPVADAVRTAWIDLNVVQCGYCQSGQIMQATALLARTPRPTDK
EIDAAMSGILCRCGTYGRIRAAIHAAATTLGG
>A0A6J5GPS9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MIELTINAQKHVVDAPPEMPLLWVIRDIVGLTGTKFGCGIAQCGACTVHLDGEPARSCVT
PVAAVGGRRITTIEAIGATPAGQKVQKAWLDIDVVQCGYCQSGQIMSAAALIASNPAPND
ADIDAAMAGNICRCGTYVRIRAAIKQAAKGA
>A0A445NEV6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces netropsis|TrEMBL
MAEPSRRGFLTYLVAAPTLAVATGLGTAGAAAAAPAGTPVPSLPAPADLVDLGDILILAG
APTAHMLVLTVGEDGRVSFRLPREEVGQGLTTAVAMLVAEELDTAVDRIDIRLEDARPEL
LFGQFTGGSNAIRSLYGPVRHTAAAARARLVRAAAERWGIAASGLRTRDGAVVAPDGRSA
PYGSLAVEAAARDLGAITAAPKPESAHTLVGTPTSRIDARAMVTGQQRYTLDLDVPGAKP
CMVRRPPTLGGTVQSVRNEAAVRAMPGVLDVVTVPTGVAVVAETFGQALDAKNKLDVAWG
PGTVDGLSDDDIRARLRSAAAPLVDLPPLTRHIDAEFDFAFASHAPLETNSAVADVHADR
ATIWSGLKGPIIAQQTIAKELGLPVDKVTVHVVQAGGSFGRRLFFDAALEAARVSRRSGR
PVRLMWSRVDDMRHGRMRPATHHRIRATYALGKVLSFDHRVAAVETDFRHGLGEILTATA
TKLPGGLGNAAFAQTLFHTTVKCPYHFGVTTQHLTEVPLKMPTASWRSVYSANTRGAEEI
LVDELAAKLGKDPVEFRRACLKNPAQRAVLDKVAREGEWGRPMPAGHAQGIGFHEEYKSR
TACLVEIDARDPGKPRVTKAVIAADVGRPINPRGLEAQLLGGLTDAISTTLRAGLHIDEG
LPLEGSYSQFHYARQKDSPPDVRIFIMPATGEPGGAGELGVPAAVGAIANAYARATGTRP
RRFPVNFDVDFTPFPR
>A0A7W6DHK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium fontiphilum|TrEMBL
MAKRNRRQGEHGLNRRALLVGGGAAAGLLIAWGVWPRDYAPTLNAGPGEEVINAFLKIDR
SGQIIVIVPQAELGQGVTTQLPQILADELGADWRTVAVQSAPVSPLYANSLLARQWLSND
LSMLAGGAGEWAIDQYAIRNALMLTDVDSSVPMFHDSYRDAGAAARVLLCQAAAARWNVP
WESCDVVDGVVTDGAQRRLRIGEVVAEAVRFDLPPILPLRQGNDGRLAGQDLPRLDTPSK
IDGSHNFAADIRLPDMVYASIRQGPIGDAILASANESAAKGVTGLLRFLRRERWIAAVAT
NWWAANKALDLCDPVFTLRGRPVDSGGIEEALEAGFASDAGRRLFRQGDLLPVFEGATIL
ASEYGVEAALHLPMEPMSATARVTDDKAEIWTATQAPGLCRSAVADALGLSDAAVTLYPL
HGGGGDGRRFDHEVAVQAAILAQEMGRPVQLTWSRLEDVIQDRPAAPAHARMAAKLGRGG
MIEGWLAKVSAPCAVTQSWARMADGALPHEAAADTADKASRLALSGMVPPYAIPNFAVDH
YPVDVGLPIGLSRGNADIYGAFFTECFMDELAHLAGMEPMSFRIQMLGGRPRLAHCLTTA
AALGGWQGGISGSGQGLAAHSMDGSHAAVLVEAGIEGNRLAVSRIVAAVDCGDQVNPDIA
RQQIEGGLIQGLAIAMGATAPYAKGLPTRAILGRMGLPRLADIGEVTVELLASAVPAGGT
GGIAVAAVAPAIANALFTVTGQRFRNLPLLARD
>A0A7X0NVV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea rubra|TrEMBL
MTGPHGGAPDEGIGRRRFLGYVVAAPTLVAAAELVPPAPPAAAAPAPAGLPELTELLDLN
DVMTAAALPTSALISVEVRPDGTVAFALPRAEVGQGITTSTAMLIAEELAVPLERVRVTL
ADARPELLFNQLTGGSNTTISTYVPIRVAAAIARDRLLAAAAAELGTPVTGLTMKAGMIS
DRSGRTIDLGALAEKAASTRTQQVSVRLAPRESFTVIGRPHNRVDARDAVTGRKKFTMDL
DIPDARPTMVCRPPTINGKVGSVANLAEVRAMPGVTDAVVISTGVAVRAETFGQCIDAVR
ALKVTWRPGTTAGKSDESVLRELHAAELPMGLRPPTPVVEGAFTFYFRSNSALEPNCAIA
DVRDGRAEIWSSLKSPIVAQQAIAAKLGLPVGKVTVHVTEGGGSFGRRLFFDAALEAAEV
SQKLGKPVKLMWHRADDSRQGRTHPMAISRVRVSYLGDTVLGYKQRHTSVSTDLGHGLGE
IFTALAARLPVGDIGFSQTFFHLSQAMSYDFGITSRLLAETDKSFNTGSMRNVYSPDVTC
ARELIVDQLAARMGKDSYRFRHDFLGDERSRAVLAKVAEAGGWGRPMQPGTAQGIAFHAE
YKSVSACLVEIDCRPETVNRPIRDGVGGPRVTKAVFAVDVGLAVNPRGLEAQMMGGIMDG
IALALTSSLHLRDGYFLEASWDNYFYTRQWNAPPDLRIIVMPSTSDQPGGAGELGVAASM
AAVACAYGRATGTMPTSFPINHGTLSFTPKPTVPPIPPSPADGLNGGGASA
>W7VTT9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium sp. T29|TrEMBL
MDFALVAKRLAGQSPAPDTDARSGEFDRRGFLKLSALGGGGLAVTWSAPAALAAEEGAPA
APKKPVDPSPFIKIYPDNTVEIRVNRLDFGQGALTALPMLVAEELDVDWKHVRASLAPAG
EAYKDPLFGIQMTGGSSAVPNSWLQYRQVGAATRMMLVAAAAAQWKVPAEACSTEAGVVR
HGSKRATYASLAAAAAKQPVPSSVALKAPADYRIIGHGKGRIDAVASVSGKKRYGIDHRL
PGMKVALLQRAPTFGGQVESFDASKAKAIKGVIDVFQVSTDRGGTGLAVIADGYWPAKQG
REALQVKWKAGVGGTVSSDKLLAQYRDEAKAPKLTALAGDGAAIEAAAKAAPKKISAEYE
FPYLAHAPMEPLNATFELKADRATVWAGTQFQTVDQTAIAQTLGLKPEQVTLNTLPAGGG
FGRRAVPSSDYLREAAGIAKAWHAKDPKSPLMVMWSREDDIKGGYYRPAHLHRVDIALGA
QGQVQGWDHVIVGQSLVKGTPFESFLVKDGIDHTMTEGVVENTYGMPMRLRATHPDVAVP
VLWWRSVGHTHTGFVMETLADEVARAAGQDPVAWRLAKLDPKKHARHVAALKLAVDKSGY
GKSLPAGHAWGVAVHESFGSVVAYVVDVSLIDGRPKVHAVTAGVHANQVVNPTAAEAQIQ
GGAVFGLSMIQPGFAITLKDGVVEQSQFSDFAPPRITDAPPVAVHFVPSNDPPTGLGEPG
VPPIAPAVANAVAALTGKRLRKLPFEALA
>A0A839YWZ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomicrobium lutaoense|TrEMBL
MSSILLNGDPVRFHLDPETPLLFALRDAANLTGTKYGCDHGGCHACTVIVDGQAVRSCRL
RLRELEGASVTTIEGLSAGGRHPVQRAWVEEDVSLCGSCEPGFIMAIAALLATNGRPEPA
DFQALPNLCPCGGRAGFVRAGMRAARLVQASEDAPTPAPAPPEVSE
>A0A6J5AMM1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sediminicola|TrEMBL
MIEIVVNDTRHSLDNVPEDMPLLWVLRDRLKLTGTKFGCGGGFCGACTVHLEGEAVRSCL
LPIAAVAGKHITTIEGLSKDGTHPLQLAWVAEDVPQCGYCQSGQLMQAASFLKDKPTVND
ETIATAMSGNICRCGTYSRIRKAIKRAASGDPALASVTWVESICASVCTSTKEEA
>D4X3L8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter piechaudii ATCC 43553|TrEMBL
MPQCRARRDSGIIGYRSGPFLFMPLPQPQLLPGALLAHPDALLVVREPSAPPKPAPGQPG
SASNYVQPTPEIFIAIVRDAGLIADDLPSPGWRVLAFNGHVDLGTGIRTSLAQIVAEELD
VPLSRLDMVLGHTSAAPNQGPTIASASIQISAVPLRRAAAQAREHLLMLAAQRWDLPRDA
LHVRDGVVQPVDAAPHGEAHRLSYGDLLIGQHIRLTLMPPDQPVRLKPASEYRIVGQGVA
RVDIPAKATGELSFVHDVRVPGMRHGRVVRPPHPGRDAGDFIGRCLIDVDHASVAHLPGN
VQVVVQGDFVGVVADREEQAIAAMRALKVSWRPVTPAPSLADVAAAIRAQPARARPLIDE
GDVDAACAQAATHLRRTYVWPYQMHASIGPSCAVAEFQDGRLTVWTGTQNPHMLRTDLDR
LLNLGEGQIDLIRLEAAGCYGRNCADDVCADAALLSMAVGAPVRVQLTREQEHQWEPKGT
AQLMDVGAAIDAQGALLAVDFAVRYPSNDAPLLALLLTGVVSGEPRTLEMGDRTATPPYR
YAARRVVCHDMPPLVRASWLRGVSALPNSFAHDCMIDELAEAAGVDPVEYRLRNLDDTRA
TALIAATAKQAAWTPHATGSRGKPQADGLLRGRGVAYARYVHSKFPGFGAAWAAWVIDLS
VDPASGRVRVERIVVGQDTGMIVNPGGVRHQVHGNVIQTLSRCLLEKVDFDEAGVVSREW
GGYPIIGFKDVPPIEVLLMPRQDEPPMGAGESASVPGPAAIANALFDATGKRFYEAPFTP
QAVHAALAA
>G3A8M2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia syzygii R24|TrEMBL
MRIRNLEALAGGGAQHPAASAPADAGVATLDRRSFLKLTSLAGGGLALGVVPALAGAQDV
QAKPPSPPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRAMLAPAG
DPYKDPTFGIQITGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSTCRTANGVVI
SGSHRATYGELAQAAMALPVPQQAALKNPSQFRIVGKPTPRLDARAKLDASLKFGIDTRL
PNMKVAVVARPPRFGGTVAKYDAAAAKAVKGVVDVVQIPTDRGGTGVAVIADGYWPAKQG
RDALQVTWDDTGSRVSSAALMSEYKTLADQPGIVAEAADVSAIQSAAKRIQADYEFPYLA
HAPMEPLNCTIDLQSEGGKVSGAKVWVGSQFQTVDQGALAKTLGVAPEKVELNTMMAGGG
FGRRAVPTSDYVVEAASVAKAYAAGGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKNTLFEPYTFKNGVDATMAEGVIENDYGFPMQVSVHHPNVDVP
VLWWRSVGHTHTAFVMETLVDEVAHAARQDPVAYRLARFTGKAHERHRQALQLAVSKSGY
GKRKLPKGQAWGVAVHESFNSVVAYVVEVSIDQGKPRVHRVTAGVHANRVINPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGATKNSNFTDFPPVCMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDAV
>A0A840GUI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR18|TrEMBL
MANLTINGKTFTLDIEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHIEGVATRSCGV
SVSEAEGKKITTIEGLASGDALHKVQEAWIAQDVPQCGYCQSGMIMAVAALLSEKPKPTD
ADIDEAITNICRCGTFQQVREAIHTIASA
>A0A5P9FKJ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax sp. THAF30|TrEMBL
MSRIGTIARRTFLVGSVAVVGGAAFGVYAARKPHPNPLQTGEGEAAITPYVRIDGDGVTL
ITPRADSGQGVYHVQAALIAEELDVDLDAIAIDPGPPAPAYWNTALGAEAAEFMVPAQGA
MHNATEGVVTAAMKLMGMQITGGSTSVPDGFDKLRAAGASARETLKSAAAARSGVDVTLL
ETESGHVILPDGSRIAYKDLAPELAETPVVQDVPLRAPEDWRYIGKPMQRLDIVAKSTGT
QTYGIDVEVEGMVHATVLLNPAQGGDLGDWDAAEALTMRGVTDIVPITGGLGIVADNTWR
AFKAARAISAEWGAPDFPAEQEGHWAALEAAFTEEARDSRKRDDGDVEAALAEGEVIEAE
YRAPYLAHAPLEPLSAIVRVNADSAEVWTGTQIPRFLQNNVARIAGIDAENVIVHAQMMG
GSFGHRLEDEVVKHAAEIAVQMPGVPVKLTYSREEDMIHDYPRAIAMGRMRGRVSEGRVE
ALDLSIAQPSVMSSQMGRQGLSAPGPDSQIVAGAFEQPFALPHQRVTGYRATGLAPVSSW
RSVGASSNGFFYNCALDELIHAAAADPLEERLRLVSDPLARAALEAVGEMSGWSGPTPEA
GLGRGIALTRSFGVHCAQVVEVRDTEAGLRIARVWVAAEVGRIVDPVNFENLVQGGVIWG
LGHAMNSEITYSGGVAQPDNFHDHAGMRIWQAPEIEVRGLENGDAVRGIGEPPVPPAAPA
LAGAIFAATGTRLREMPFNRSVTFA
>A0A1E1UZ15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. BIWAKO-01|TrEMBL
MTVHDQNLSRRSLLKGAGALVIGLHLPQVARAQSGAGAAFRPGGNATFAPNAFVRVAPDS
TITVLIKHIEFGQGPFTGLATLVAEEMDADWGQMRSEHAPADVKLYANLAFGVQGTGGST
AIANSWEQMRKAGATARAMLVQAAAQAWKVPASEIKVEAGVLSHVSGKQGRFGEFAEAAS
RLAVPDNVPLKPASAYRLIGKEGAVRRLDSADKSRGKAEFTIDIHAPNMLTVVVARPPRF
GGKVGSFDAAEALKVKGVVDVKQIGSGVAVYANGMWPALKGREALKVIWDESAAEKRGSR
ELIAEYRALARQKGVVAGSHGDAEAVLAKAGTVIEAEFVFPYLAHAPMEPLDGYLQWDGS
EALARFGSQFQTTEHMTIATILGLPPEKVRLETMLAGGSFGRRAQVSQHLAAELAMAAKA
IGPNRPVKLVWTREDDLSGGYYRPLFVHRLRGAVNEGKITAWADSIVGQSFFLGTPFEAM
VVKNGIDATSVEGANELFYEIADFHCEVNNPKVGVPTLWWRSVGHTHTAYAVECFVDELL
QAAGQDPVAGRLALMNRHPRAVGVLKAVAELAKWNGSGPVDGRARGVAVVESFGSFVAQI
AEVSLGSDGEPKVHKVWCAVDCGVAVNPDIIRAQMEGGIGFGLGHALYGEITLDQGRPVQ
ANFDTYRSLRIHEMPEVEVAIISSTEAPTGVGEPGVPPIGPAVANALAKLGQPRPRQLPM
VGGTV
>K1LKI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MANYNLKINGQNYQVDVEDDTPLLWVLRDHLGLVGTKFSCGIAQCGACMVHINGESTYSC
TLPVSSVGSDEVTTIEGLSKNGDHPVQKAWDEIDVAQCGYCQAGQIMQAAAFLRKNPNPS
MEEIENAMNRNLCRCGTYHKIREAVALAAKTK
>A0A7W6ES40|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella defluvii|TrEMBL
MAAITLDINGKKHDLDIDPKMPLLWAIRDVVGLKGTKFGCGMAQCGACTVHMNGHPTRSC
VLPVQSVVGSKITTIEGIGTEENLHPVQKAWIDEQVPQCGYCQSGQIMAAAALLKDKPTP
TDADITSAMQGHICRCGTYDRIRKAIHTAAKSKSPKGEMSGGK
>A0A0A8K118|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methyloceanibacter caenitepidi|TrEMBL
MGEAMTFKIKVNEVEHEVDVDGDIPLLWVLRDVLGMTGTKFGCGKALCGACTVHVNGTPM
RSCVMPVEYIGESAVTTIEAIGDTPIGESLQQAWLDLEVVQCGYCQSGQIMSAAALLAAN
SEPTDSDIDGAMAGNICRCGTYLRIREAIKQAAETSPTSSSQGD
>A0A4P6WYY3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hydrogenophaga pseudoflava|TrEMBL
MSTTNDSHAFETSRRGFMAGSGAALVVGFTLPSMGGRALAATDTAFTPNAWLRITPDNRV
TVVCGSSEMGQGVLTAIPQLMAEELDADWATVGVEQAPVSQAFNNPAFGMQATGGSTTVR
GHWDVMRNAGATARAMLVAAAAEQWKVPAGECRTEAGHVMHGSKKLSYGQLAEAASKQKA
PEKVALKDPKDFKILGQRKARLDTAGKTNGSAKFGIDVNLPGMLVAVMARAPLPGVKVAK
VDDTAAKAVKGVKQVITLPTGVAVLATGYWAAKKGRDALKVDWDFGDKAGLDSAKVTAML
TDGASKADAVALKAGDAGITPAKLVEATYEAPYLAHACMEPMNCTAWVKPDGVEIWAGTQ
SQGPVQGILSQVASVDPGKVKVNTMLLGGGFGRRFAPDFVIDATLLSKISGAPVKLVYTR
EDDMAAGFYRPASVAKFTGGLDAQGNAVLLKAGVGSPSIMAASGFMKIPESGVDSFAMEG
INDHPYSVPNQLIAYGRREPGPNVWFWRSVGHSQNSFFMEGFIDEMAYAAGKDPFEFRRA
LMDKQPRYRQVLEVAAEKAGWGKPLPAGVFRGIAVVQSFGSYVAEVAEVSINADGTPKVH
RVVAAVDCGMTVNPTIIERQVEGAIVYGLSAALYGRISLKDGRVEQGNFHDYPVLRHNEM
PKVEVHIVKSTEKPGGIGEPGTPPVAPAVANAIFAATGKRLRSLPFDTSQLKKA
>A0A1U7D945|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MLQYLKDFTPAVAETLTVRPMSRRAFLGGTAAFALGVFATRGEAFPTWETGAVGMPNGVV
DDPLVFVAIDADGTVTLTAHRSEMGTGSRTSLPMVMADEMEADWSRVKIVQAPGDEPKYG
NQDTDGSRSMRHHIQAARKIGGSVRTMLQRAAAAEWNVDPSQVTVEMHAITGPDGQSADF
GEFAEAAMAQPVPAHEEIAYKTESEFRYIGKGEVQITDLHDITTGKAVYGADVTLPGAKV
AMAIRPPVVGGRLVSYDAADALAMPGVVGVYELPEWKAPAKFAPLGGLAVVAKNTFTAIK
AREMIKVEWDDGPNGSYSTGPYMEEMKATALGRGKVLRDKGDTQAALSAAAKTFGQTYTQ
DHIAHIPMEPPAALASYASGKLEIWAPVQSPYTTRTDTAAALGIEPADVTVNVTLLGGGF
GRKSKADYVIEAALLSREVGAPVRMQWTREDDVRHSFYHTASAERIEVGMDEVGKVTAWR
HNSVAPTILSTFAPDPGYQFPVEAGMGHVDMPFDIANVSCENGQAAAHTRIGWFRAVSNV
PRAWAIGSFVGELAAETGQDQLATWLQLIGAPRTFDPASEGLPEGFWNYGEPYDGFPIQT
GKLAAVLQTAADGIGYGKDLPEGEGIGLSVHRSFVSYVACAAHVKVVDGRITVPELHLAI
DCGFAANPERIRSQMEGAAVMGMTVALYSGITHEDGAVQQSNFYDYDVVRANNFPRKVVT
HIMPNSFADHATGVGEPGVPPVPPAIANGLFVATGVRKRHLPMGTTV
>A0A839UQY5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Simiduia aestuariiviva|TrEMBL
MANFKVVNRREFLKLSGLSAVGISATGLALQASLPVHAEWTGASGSALSLNVFVHIATDD
QVTIVAHRSEMGQGIRTGLPQIVADELDADWNKVNIVQALGDKQYGDQNTDGSRSVVGFY
HTMREMGASAKAMLILAAAQAWGVKPEECVAVDHRVTHPKSQRALRYGELAERAAQLPLP
DPKTLKYKSPDQFKYIGKPVPMVDLADIVRGDTTYGVDVVLPDMLHASIERCPWLGGKIQ
SVEDSAARKVPGVVDIIRLDGGVEPPAFVPLSGVAVLATNTWSAQQARKKLNITWTNSGH
QNFDSEASMRALATQLPAASKIVRSRGDIAKGLNGAQQKMSAVYTVPHLEHATMEPPAAT
ARMTENGCEVWACVQAPQRTQQVVAGAVGIKPEQVKVNVTLLGSAFGRKSKPDFAAEAAF
LAKAVNRPVKVIWSREDAVRHGYYHAFSVQHFSGGLDQKGQLIALKAQVASPTIMSTFAP
DQVYLQDFEVGQGFANMPYDIPHQQASVHATPAHTRIGWLRSVYNINHAFGVNSFIDEAA
HLAGQDPLAYQLAMLGADRVVDTRNEGFEKGYNPEYPYSIARMKNALQRVKASVGWPAKV
KQGEGWGVAVHHSFLSYVAVATKVVIENNRVRVTDVHIALDCGQVVNPDRVHAQMEGAVI
FGLSLTLMGEISFEDGAVVQSNFDDYPLLRIQQSPNIVVTLIDSNEKHGGVGEPGVPPIA
PSVTSAIAAAGGPRIRTLPVSKQLSIG
>A0A5P9GVQ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. THAF27|TrEMBL
MTTFTLNGKETQIDASPDMPLLWALRDELNMTGTKYGCGVASCGACTVHVDGVPTRSCQT
YLGDLEGATVTTIEGVESEAAKAIQEAWVELQVPQCGYCQSGQIMSASALLAETPNPTDS
DIDTAMDGNLCRCASYARIRKAIHRAAEIMEA
>A0A178X8C7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. M39|TrEMBL
MTLSHSEPDTGKERAGVSRRGFLGYVVAAGTLVVAADVGLSTPAAASIPSVPQPPELYDL
NDALTDAGLPTSQLITVTINKDGSASFEIPRAEVGQGITTSTAMIIAEELDLPVEKVHVT
LAPARPELLFNQLTGGSNTTVSTYTPIRVAAAIAKQQLLEAAVILLGGTAERFIVKAGVV
TAPNGKSATYGELAAKAASSTTKQVRLDPSKLKGSGEFKVLGKPQTRLDALDIVTGKKQF
AMDLDVPGALPTMICRPPTLNGTPKAFRNKADVLKLPGVTDVAIIPTGVAVRAETFGQCI
DGVRALQVDWGPGSVEGENDETVLANLRRAELPLAVPKVPVLAKTVEADFEFMFRSSAAL
EPYCAVADVRDGSAEIWAGLKSPIVSQGEVAQAIGLPQGKVKVHVITGGGSFGHKLFGNH
AIEAAQASKAFGKPVRLMWHRADEPRQGRLHPMATSRMRATVLAGQVLTFEQRHTSVETS
FRHGLGEMLTSVATKLPTGLGNLGVAEAVFVLSQEMPYNFGVVDQTLTETDQRFNTGSMR
NVYSPDVGCANELMVDILARAMGKDPLDFRLEYLKNDKVKGVLRKVAEVGGWGKKMAPGT
AQGIAIHKEYKGASACLVEIDCRPETVNRKIRDGVGGPRVTKAVIALDAGLVINPRGIEA
QIMGGFADGLALALTSSVHLKDGHFLEASWDNYFYTRQWNIPQDFTAIAMPSNGQQPGGA
GEAGVACSVAAVACAYARATGKVPKRFPINHDDPIGFEVKSFVPPVPESPTDGLSHTY
>A0A2R8AX43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoprimorskyibacter insulae|TrEMBL
MSRIGKIARRTFLIGSAAVVGGVAIGAWYVSRPAPNPLTPQEGEASLNAFVVIDGNGVTL
VAPRAEMGQGVRTTWAALLAEELDVNWEDIKVIHGPAAAAYYNSAMMASALPGIEYRKSE
FTRNLGEALGVIGKVFEMQITGGSTAMRDGYERMRATGAAAREMLKEAAAKRLDVKARDL
RTEGGAVIAPDGTRLTYSELAADAAAQDPRDVALRDPSQWRYLGKSLPRVDIVEKSTGTA
TFGIDVRVEGMKFAALKVSPRRGAMNGFDASAARTMPGVEQIVDVGDGVAVVASNTWLAM
QALEAITFDWGPAPYPATTDAIFAPIAAALGAEPTATPRDDGDASTVPDGATVVEADYSA
PYLAHATMEPMNATALIDADGLTIWAGNQGPTILRDRCAEVAGLDADQVTVHTTYMGGGF
GRRGEVDFGQYATRVAMALPGVPVQLTWSREEDMTHDFYRPGTMARMRGAVKNGTAVMLD
AQVASPSPSQQALKRWMGFAPGGPDNVITEGLANQPYAIPNYRCRNHQADVAVPIGFWRS
VGNSHNGFYMESFMDEMAHAAGADPLDFRLDLARREWAPAAGVLQAVKDMSGWTGQTPDG
TGRGVAMCYAFGTPVATVIEVQDEGGAIRIAKAWMACDPGIALDPSIIEAQMFGGLVYGL
SAAMSEEITFDNGIAQQENFPDYEALRIHQMPQVEVRILETLPHISGVGEPGTPGAAPAL
ANALFDLTGKRARQLPLNKMFDFI
>A0A6A7SK60|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|wastewater metagenome|TrEMBL
MAIDLEVNGVARRYDGPPERPLLWYLREDLGLTGTKFGCGVALCGACLVLVGDAAVPACR
TAMGGLHGTAVTTIEGLAARDDPVIAAWRDAQVPQCGYCQPGQVIAATALLRTTPRPSPT
QTEAAMDRVLCRCGTYQRARRALAALTGGRHG
>A0A7Z0CLR1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides aromaticivorans|TrEMBL
MPKHTFQLNGETVTVDVEDDVRILWVLRDVLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVSAIGEDDEITTIEGLADTAPGDGLHPMQDAWLEHDVAQCGYCQPGQIMAAVALVNK
VRAEGRAITEDDLDSIRNVCRCGTYSRIREAVRTGAAAMGG
>A0A3B0V1C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MSTIKNISRRTFVKSIGLASGGLILACNTSVFSDKEITKNLVDFNPNLFVQLNSDGSLVL
IASRSEMGNGVRTSLTSVIADEMEANWDKVIVKQATGDAKYGDQNTDGSRSVRYLYETMR
KMGAMAKAMLISAAAKKWQVSESECTAENHFIIHSSGKKIGFGDLVEIAKTLEVPTDISL
KSPKDFKYIGKNLKSIDVEDYVKGKAVFGLDKRLPNMKFVAIARCPVTFGTVKSFDKSEA
LKITGVEAVIEIPRIERPFGALGGIAVIASNTWAAFKGKEALKIEWNLGDNKNYNSKKYM
AEITANVHKQGKVAKDVGNINKAFKNASKIVESTYQLPHLSHAPMEVPNAVAWVQGDSCE
VWAPTQAPQTTRKEVINYLKTSEEKVTINVTFLGGGFGRKSKPDYVVEAVMLSKELNAPV
QVVWTREDDIKHDYYHTVSAQYLKASLDKNGNVTGWLHRFALPSIVSTFSPGVDYAAGFE
IASASNVPFDIKNMKIEVGKAPAMVRIGWLRSVINIPHGFSENVFADELASGANKDPLEF
RLNLIGKDRIEDTQNEIKYNTARLKNVLKIAAKNAEWGKQLPENHAYGLAVHYSFYSYVA
SIVEVSVINKKVKVHNVFTAIDCGTVVNKDTVKAQMEGSAIFGMSLAFYGKITAKDGAIE
QNNYDNYKMIRMHEIPKVHVEIIESSEKPTGVGEPGVPVIAPAIVNAIFRATGKRYRNLP
LSDYGLV
>A0A170QBV7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MKKYIININGERKGITIDGETPLLWVIRDELKLTGTKFGCGRGLCGACTIHIDGEETRSC
ITPIENADGLKITTIEGLSENSSHPLQKAWIAEDVPQCGYCQSGQIMTAAAFLSRNPDPD
EDDVNSAMRMNICRCGTYNRIRKGIMVAAKEMKNG
>A0A3B0SE16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MAVEPEKDQESSGSAGLSRRKFLIAGGAAAGLVVAWAIWPRSYEPNLSATENEEIFGAYL
KISKDGQVTVVVPQSEMGQGVYTVLPQILADELGADWRTVAVEPAPINPLYVNNLLAREW
AETLLPAGSENLTDNATAKWIADNIATRNDFILTADSTSIPNYADSFREAGAAARVLLCK
AAAEKWNITWEACEVKNGIVSNGDSELRFGELIAEAVLQNLPDPVPLRPSGENNLVGQDV
PRLDLPSKLDGSANFAGDVRLPDMVYAAVRQGPVGETKLKSFNREGANKIVGLIDVIDTE
NWIAAVATNWWAANRALDKMSPVFETTGLLPDSEKIDAALANALDDGPGVRFVKRGETKP
PFDQYRNIQARYSAEAALHAPIETRTAAADYKDGRLQLWIATQAPASAAKAAAKALGIGR
DAVTLYPMLAGGSFGRNLDSEIAAQVAVIARKMDRPVQLMWSRAEELMHDHVRAPAHARL
DAATNKAGGIEAMQIKIAAPAAAREQSLRLFREMDAITAMRQSNGEADIKAVEGADIAYA
IPNFTLDHHPAYVGVPTANWRSNAHSYTAFFIESFIDELAQKAGVEPLSYRMQMMSGQPR
LARCLTGVAAMAGWDGGIDGSGQGIACHSMRGGHIAVIVTASRSDSGLKVRRISATVDVG
RIIHPDIARQQIEGGIVFGLAMAMGSATRFKDGLPTAKRLRDLSLPRLAEIPPIQVEFIK
SEEEPVGVEEIGVPAVAPAVANALFSATGTRFRQLPLFGEPG
>A0A3B0YL45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MKKINRREFIKCSVSSTVFVLGINLSESKNAFSSEINNEESFSPNIWLKIDSQNKCTIIL
PESEIGQGVFTGLATLIAEELDFDWSQITVERASSADIYGYQTTGGSSSIRSGWIKFRKA
GAIARYMFVEAAAKKWKVPAARCQTKNGIVYLKKSDKKFQYSELISDANKVNIPQNIILK
NADQFNLIGKKGSRVDSADKVTGKAIYGIDVQLPDMLIATSVHPPVFGAAPGKVDDVLAK
EIPGFVKAIKIDNAVAVVAKDYWSASKAAKALKIEWLYSGKLINDEEIKQKLKRAIENKG
AVAQSLGEISAATDKKQITAEYSVPLQAHATMEPMNCTVHIHNGICEIWAPTQSPTAAKE
IAEEYYFNAADRVWKKVKTLLKSNEDDIVVHTTFSGGGFGRRLKQDFVAEAVQIAMGFSQ
PVKLIWSREEDMQHDCYRPVSHSKLQAQVDDQGYPVSILHKIASPSIRESLNPGYLKRKK
GLDSSAVEGARHLAYAIENHKVIYNYVDLPVPLGYWRSVGASINAYHIESFIDELSHKAN
IDSYLYRKELLQFNPRILATLNAVASLSGWKNDSHAFYGIACHSSYGSHVSTVAKINRKN
NALELSSIYCVIDCGQYVNPDIVKAQLEGSVVFGMSALFSEINIQNGRVLQSNYHDFPML
RYHQVPEIICEIIQSAEDPGGAGEPAVPPTIPAILNAVFAATGERIRDLPIKQSVFI
>A0A0P1IS27|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cognatishimia activa|TrEMBL
MKLSVNGKDREVDVEPDMPLLWVLRDELGLTGTKYGCGVAQCGACTVHMDGLAVRSCQLA
VGDVTGDITTIEGLGTPDSLHAVQDAWVEHQVAQCGYCQSGQIMSAAQLLDFNDSPTDAD
IDAAMGGNLCRCGTYPRIRAAIKSAAQKIQEA
>A0A841KIS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Oleiagrimonas soli|TrEMBL
MQAQPVQTPPDTITRVPPRNGIELRINGESYLHTGDPSMPLLWYLRDVLQLTGTKYGCDS
TVCGACTVLIDGKRALACARSMDTLAGSEVTTVEGLAGPDGSLHALQQAWIDEDAILCGY
CQPGWLMAAADLLRRKPAPSDADIDALPNLCRCGSQPRIRRAIHRAAAQLQAAKGSK
>A0A108UBN9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lysobacter capsici AZ78|TrEMBL
MNAVPSNSRRQFLKTGALIGSGLVVGFVLPAASRFAQADPAAAAAAAQPFAPNAFLRVGS
DDSVTVLLSHSEMGQGIWTGLAMLIAEELDADWATIKVEHAPAAQAYAHTAFGMQMTGGS
TSTWSEFDRYRQAGATARALLVAAAAQRFGVPVDQVRTENGVAIAGDKRARYGELALDAA
KLPPPKAPLPLKDAKDWKIIGKSTKRLDGPEKITGKAKFGMDVQFDGLLTAVVARSPVFG
GSVKSFDASKAKAIAGVRDVVQVPSGVAVIADHYWAAKQGRDALVVDWDLGPNAGLDTVK
LREQFRALAATPGAVAGQAGDVKGALAKAAKTLEAEYNVPYLAHSPMEPLNCTVKIDADG
CDVWTGTQFQTVDQKVAAQITGLKPEQVRIHTMFLGGGFGRRATPTSDFVTEAVHVAKAA
GKPVKTVWSREDDVRGGYYRPMYLQRARIGLDAQGLPIAWEHVLVGQSITAGTPFEPMMV
KNGIDATSVEGVADSPYIAGLKDFRVDLHSPRTGIPVLWWRSVGHSYNAFVMESLVDELA
YAAGKDPVEYRRALLKDHPRHLAALDLVADKSRWGSKLEAGRGRGVAVHESFGSYIAQVA
EVSLVDQPGGGKGIRVHKFFCAIDCGIAVNPDGVHAQMESGINFGLGAALHSALSFKDGR
VQESNYHDYRVLRLDEAPQIEVHIVPSTEKMGGAGEPGTAPVAAAVANAVYALTQQRLRE
LPLRLPA
>A0A841AZB0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis umgeniensis|TrEMBL
MPNYTFTVNGKTVTVDAPADLPMLWALRDKLGVRGPKYGCGINVCKACTSHLDGEAFNPC
VTPVSDCSGKDVTTIEGLADGEDLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKKTKNP
TDAEIDAIQNVCRCGTYFRIREAIKSAAAKM
>A0A166ESQ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. WM33|TrEMBL
MAISLKLNGQTHKVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLDGEPVRSCQ
TFIEDVEDSEITTIEGLKSTPAQAVQQAWTELDVVQCGYCQSGQIMSAVGLLSENAKPTL
EEIDDYMDGNACRCATYQRIRSAIVRASEIMEA
>A0A839UD20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MLPNIDYSELPRALQHMLERGRSTAAQALPRRSFLKMAGGFGLAVGVFPHLAGAQSSGAS
AATSNLKPTEQPSAFVHIAPNGEVTVTINRLEFGQGVHTALPMILAEELDADWSLVRSQL
GTNDMAYADPLFGIHLTGGSHTIKNSFTQYRELGARVRAMLLGAAAERWNVDVSTLRTEA
GMVLGTGGRKLGYGELAEAAVAFPVPQTIALKDPKDFRIIGQPTQRLDAKAKSSGQQAFG
IDFKLPGQLTAVVARPPVFGGKIASLDESAARAIKGVKAVLRVPLDGGAEGVAVIADGYW
QATRGRDALTLEWNTSAVEKVDSERQLAQYRELATSPGPLKFDADVAPLATAPQQLEAEF
IFPYLAHAAMEPLNCTVSLTVESAEIWVGSQCAGLDAGAAANALGLKPEQVKLNVQMAGG
GFGRRFSSTSDTVVEACQVAKAARAAGLTAPIRTLWSREDDIRGGYYRPMHLHHARIGFD
ESGKVLAWDHVIVGQSITTGTVFGEFQVKDGVDSTATEGMREPYGLPMRLTVHHPKINVP
VLWWRSVGSTHTAFVMETLLDDIARATNQDPVAYRMQLFGDNHPRHRDALQLAVDKSGYG
KTVLPEGRGWGVAVHESFDSVVAYVVEASVTDGQPKLHRVTSGVHCNLAVNPRTIEAQVQ
GAAVMGLSMCLAGSAITLKDGVVEQSNFSDYTVARITDVPAFDVHIVPSADAPTGMGEPG
LPPLAPAFANAVARLTGKSLRQLPFDLA
>A0A839U579|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MTIHNITATRRSFLAGAGLVIGFTLAPKVFSAQALEGVPAGGAETLSPMNAFVKIGADDT
VTVLSKHIEFGQGPFTGLATIVAEELDADWSQMRAVHSPADDKVYANLAFGLQGTGGSTS
IANSYEQLRKAGATARAMLVSAAAAEWNVPASEITVSKGRIKHDASGKESGFGALAAKAA
TQTPPAEPTLKDPKDFVLIGQELPKLDTLSKTNGTAVYTLDITADNMLYAVVEHPAHFGA
TVKSFDDSEARKVQGVVDVKQVPQGVAVYADNTFAALKGRAALKVEWDLSKAETRSSDQL
TADYTKMFAETGIQATHNGDVDKAFGGQGVQSLEATIVFPFLAHAPMEPLDAVFIKRADG
SVDVYNGAQFPGMDQKTAAKVLNLDPAKVRLNTQITGGSFGRKAQFGSPYMQEAAGVFAA
TDGRRPLKHMWTREDDIRGGYYRPMYVHKMRGAMGTDGQIVGWDQTIVGQSIMGKADLDS
TSVEGASDLPYTIPNLRVIAHNTKLEIPPLWWRSVGHTHTGFAVETFVDELLQKVGKDPV
EGRLALLSKEPRHMGTLKKVAEMANWGSPVPEGRQRGVAIVKSFDTYVAQIVEISLGEDG
APRVHKVWCAVDCGVAVNPNVIAAQMEGGIGYGLGAVLFDAITLGDGGKIVQSNFHDYRS
LRINEMPAIEVAIIPSTEKPTGVGEPGVPPVGPAVANAWRRLTNNPVRQLPIVNVLSA
>C1DVU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfurihydrogenibium azorense (strain Az-Fu1 / DSM 15241 / OCM 825)|TrEMBL
MKKLKINGKFFNVNLSDDTPLLWVIRDHIGLTGTKFGCGKGICGSCTILLDGNPVRSCIT
PLKLAINKEIITIEGIPEDHPLKRAWIELQVPQCGYCQSGQIVEAYALLKNNLNASDNEI
VSIMSSHLCRCGTYNRIKKAIKRAQSLLKKEG
>A0A166ERZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. WM33|TrEMBL
MRLFVNGSEFDVPDSWQDETLLMVLREQLGFVGPKLGCGQGECGACTVHINGEAARSCSI
YAIDVQSDSITTIEGLASADGVLHPVQQAWLDERVAQCGYCQAGQIMQAAALLNEEPNPD
DQTIIDHMSNNLCRCGTYKRINLAIKNASQVMQTRKAS
>A0A839U605|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MDTLNLDAPTSGPSTSRRTFLKGGGLLLGFALLGGMTTSVFAANAAQVTEDEVKAPFAPN
GFIRIDPKGTVTLVMPMVEMGQGTYTSLAMLLAEELEVDLDQVQVQHAPPNDALYANSIL
HIQSTGLSSSVRAFWTPLRQAGAVGRTLLIAAAAKQWGVEPGTCKAAHGVVTDGSGSKHL
SYGELAEAASKLPVPAADSVKLKEPKDFTLIGTPAKRLDTPMKVDGRAIYGIDTKLPGMK
VAAIAISPVLGGKVKTVDEKAALAVKGVHQVVKIDEAVAVVADHLGAAKKGLEAAAIEWD
DGPHATVNSADIIKELEEKSKQPGAVARNEGDAEKALGSAAQRIDAIYQVPFLAHATMEP
MNCTVHMQKDSCDIWVGTQVPTLTQMFVAGVTGFPKEAIRIHNHLLGGGFGRRLEPDGTV
LAVKIAKHVDGPVKVVWSREEDIQHDMYRPYYYDRMSAGLDADGKPVAWTHRIAGSSIFA
RYVPQLFVNGLDPDAVEAAAEPPYALPNIHVDYVQVEPPGVPTAFWRGVGPTHNVFVVES
FMDELAHAAKQDPVAYRKALLTNNPRALGVLTLAAEKAGWGTPLPDGQGRGVSVAFIFGS
YVAQVAEVEVGTDGAVKVNRIVCGLDCGMSVNPDTIEAQIEGGSIFGLTAALHGAITIKD
GRVEQSNFDNYLPMRIDEVPVIETHLIKSSEAPGGIGEVPTSIVSAAVTNAIFAATGKRV
RTLPVDPEMLKSSS
>A0A1B7JNW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Providencia heimbachae ATCC 35613|TrEMBL
MSKAKKIFGYGALAIVVIVVGGFALSWQSAIAPIDPYVKQTFSAEQITRGEKLAALGDCS
VCHTRARGDTNTGGLAMKIPFGTIYSTNITPDNETGIGLWSYEAFERAMRHGVDREGNYL
YPAFPYTAFTRTTDEDLHDLYAWLMSQKPVSYQAPKTSLNFPFNIRQGIWAWNQLYLTAG
PAKADTTQSDVWNRGAYLTEGLGHCSACHSPRDILFGEKGGKDHLMGGDAEGWTVPALLG
NSPSPMPWTHQDMADFLRTGYSANHGVAAGPMAPVIREGTSQLTEEDRQAIATYLTSSTS
NTQEIRSATDIALQTEDKIEPLSSEGARLYSGACMACHAQAKGAQMSGIRPALALNTNLY
AETPDNAIRIVLDGIQYEATEGLGSMPAFRHNLSDSQIATLLNYLRTTLIEKAPWPNLEQ
KVAEIRTETAGK
>A0A0H2M732|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax paradoxus|TrEMBL
MKPAAGISRRSALQAGGLALAFTWFGAGKAFAAISPRQQPGDAAAALADGNPAFAPNAFV
RIDADGGVRLVMPMAEMGQAIYTGSAMLLAEELGVELDQVRVEHSPPNEALYGMPLLGGQ
ITGGSTSTRGTYGVLREAGAVARTLLVSAAAEQWKVDPESCTVARGVVSHAASNRRLGFG
ALASAAAKLPMPEKVTLKEPKDFKLIGQPLRRVDSAGKVNGSTQFGIDVRLPGMKVATVR
ACPTLGGVLASVDDKAARAIPGVIDVLRIKDAVAVVGEHFWAAKRGLDALTIQWTPGQNA
ALTTLQLRAALANALAKDKAILGKETGKRPEGTLVQATYDLPMLAHATMEPLNTTVHVRP
DQCEIWVGTQVPTRCVSAAAKIAGVAEDKVVLHNQYLGGGFGRRLETDSVEQAVAFAKQV
PYPLKVVWTREEDIRHDIVRPMYHDDISAVVDSDGHILWFGDRIAGGTVLGRWAPAFMGK
DGMDSDLIECVAEPCYDLPNLKVEWVRHDMPAGLNVGWWRGVGPTHNLFVMESFIDELAH
RAKKDPVAYRRAMLKKNPRTLAVLDLAASKIGWGQGALAARVGRGVAVGDAFGSRVCAIV
EAEVTPQGEVRMRRAVVAVDCGIAVNAGSIEAQIQGGLLFGLSAALFSEITLREGAIEQS
NFHDYRMLRINEAPPVEVHTVKSGEAPGGLGEVGTAIAAPALANAIFAATGVRLRALPVN
RALLAQDKEALKKKIADSGFSGSNGLDARSAV
>A0A654CZD6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. AX6|TrEMBL
MPRLTVNNQPVEYLMPAETPLLWALRDASNLTGTKYACGNGDCGACIVDVDGQAVKSCRF
TLEAAEGTFVTTIEGLSRDRTHPMQQALLASNVVQCGFCIPGIVMNMAVLMKRNPRPAQE
EIERVVTNICRCGIYPRLAEAIQQAIRISAGDETVAPAPRPGIEPEEAARDVPALVVPR
>B6AZM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium HTCC2083|TrEMBL
MATSITVNGKERSVDLPEDVPLLWVLRDELNLTGTKFGCGVAACGACTVHIDGVAVRSCQ
TPLSDVDGEVTTIEGLGTPETLHALQTAWIEHQVAQCGYCQSGQIMQAASLLADIPNPTD
ADIGDAMQGNLCRCGTYPRIRAAIHSAAKASQGA
>A0A0N7M0C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tropicibacter naphthalenivorans|TrEMBL
MPTTLTVNGQTHDIDLPGDVPLLWALRDALNLTGTKYGCGVASCGACTVQIDGQAVRSCQ
VAIEDVDGEVTTIEGLGTPDALHRLQKAWIDHQVAQCGYCQSGQIMQAAALLAEAPDPTD
AQIDAAMSGNLCRCGTYPRIRAAIKSAAKGA
>A0A1S7SIK2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Agrobacterium sp. NCPPB 925|TrEMBL
MKLLVNNQTYDVDSEPDTPLLWVIRDELGLIGTKFGCGLAQCGACSVLVDGQITRSCVTP
LDGVIDKKVTTIEAIQEDEVGRRVVAAWVAHQVPQCGYCQSGQVMAATALLKKTANPSDD
DIAAAMINLCRCGTYNAIKAAVNDVAERTEATL
>A0A7W6RXJ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseospira goensis|TrEMBL
MVHRLDRPTPGTATAGLRPSRRDLLRVTAGVGAGLTLALMLPGGAAPAQDVAAAKDAGDA
PFAPNAFIRVTPDNTVTVVIKHLEMGQGVFTGLATLVAEEMDAAWDQIRPEHAPADATRY
NNLFWGPVQGTGGSTSLANAFEQMRRAGAVARAMLVHTASEAWGVEAAAVTVEAGVLRHA
GSGREASFGAMADAAGRLTPPDPQTVDLKAPDRFRLIGQTALPRPDTAEKTDGRAVYAID
VRLKGMLTALVRRPPRFGATLRTLDAEAARAMPGVRAVVRLPNGVAVVAESFWQAQKARE
ALKIAWDDSAAVTTGSEAMLEDYESLAQTPGTVFRNDGDALAALTEPQARVVEARYTVPF
LAHAPMEPLSAVARLTDSGIEVWAGSQTQTFDVLNIAEAAGLRPDQVTLHTVFAGGSFGR
RASVGSDYLREVAGIARGLTNQGIEAPVKLIWTREDDIRGGFYRPMALHAVTGALDATGR
PVAWRHRVVCQSIMAGTPFESVFVKDGIDGTSVEGVSDLAYAVPNVMGDLHSPTSPVPVL
WWRSVGHSHTAFAVESFVDELAHAAGADPLILRMDLLRDQPRLLRVLALAAEKAGWGLPM
EPGRGHGVAVHKSFNSYVAHVAEVTATDGGFTVDRLVCAVDCGVPVNPDIIRAQIAGGSA
FGLSAALRSRLTLDDKGVVEQSNFHDYEVLRLAAMPEVEVHIVPSTEPPTGVGEPGVPTV
APAVANAVFAATGTRLRRLPLTLG
>A0A7W5IM76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WP4_3_2|TrEMBL
MQFTLNGQPFDFDGDPDTPLLWVIRETAGLGGTKYGCGIGACGACTVHLEGEATRSCVLP
VSAVAGRNITTIEGLSPNTAHPVQQAWIAKDVPQCGYCQSGMVMAVAALLKQHPHPTDAQ
IDQGVTNLCRCATYHRIREAVHAAADH
>A0A7W5H0B7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas fontilapidosi|TrEMBL
MVTLTINGREHELDVPDNMPLLWALRDIVGLRGTKFGCGIAECGACTVHLDGAATRACIT
PVSAVQGREVTTIEAMADDAVGQRVQAAWLDLGVAQCGYCQGGQIMNATALLKTTPEPDT
QDIVDAMAGNLCRCGTYNRILAAIERASGKEASS
>A0A2S9XBF8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Enhygromyxa salina|TrEMBL
MKLSIEVNGDRHDIDVDPETPLLWVLRDELRLTGTKYGCGVAQCGACTVHVDGRPRRACV
APVRSVVDKRVTTIEGVSGPTADAVRKAWVSIDVPQCGYCQSGQIMSAVALLTKIRRPSD
EDIDHAMSGNICRCATYIRIRRAIHQAAGDAE
>A0A375HT91|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus neocaledonicus|TrEMBL
MNANATTPSRGRRRFLLGALGLGGALVVGWGVMPPRSRLGGPAVFPEKSGQIALNGWIKI
TPEGNVILAMPRVEMGQGIHTALSMLAAEELDMPLTRVSIESSPIERIYGNVVTLGDSSL
PLHPDDADKTWARALHWIMAKSAREIGLIITGASSSMADGWQPVREAAATARATLVEAAA
REWGVQAAQVTVREGQLIGPGGKQMPFSAVARKARDIAPPSSVTLKPAAQYQLIGKPAPR
NDIAAKTDGSARFAIDARPPGMLYAAVVMCPVIGGKLKTFQSKAALAMPGVRYVVPFEGS
TGGAPGVAVVADHYWQARQALEKLEPVWDNGPHASLDSADIRQQLVGALDSDKGGFTYRS
MGDGLKAFDKTGGGTIVEAEYSVPYLAHAAMEPINCTAQVTRDGVQLWAPTQVATLAQLV
AARAAGVSRDQVQIDIPLIGGGFGRRLESDFIGQAVSIATRTEGRPVQVTWAREDDIRHD
FYRPQAIARLKARVENGKVTAIASRSAGQSILAGELERLFGAPSLGIDRYAAEGLFDLPY
EIEHEHIAHLVVDLPVPIGFWRSVGHSYTGFFLEGFLNDVAAAARLDPLAMRRDLLKAHP
RELKVLDTAAQAAGWNRPLAPAADGAPRARGLALHNSFGSVVAQVAEVSLEDGKPRVHRV
ICAVDCGTVVNPDIVAQQMESGIIFGLTAALYSQIQIKDGRIVQTNFPDYPMMTMAQTPV
IETHLVPSTAEPSGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMV
>A0A375HS16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus neocaledonicus|TrEMBL
MKLQLKINDRRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGSVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLKDNPSPRP
EDVRAGITNLCRCGTYPRIERAILRAANAQNAGESKGRASS
>A0A1Q8KHI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae707_Ps1|TrEMBL
MSTQTFKLNGETVTVEVEDDVRLLWVLRDVLGVTGPKYGCGINVCKACTSHVNGKAFNPC
ATPVGSLEEGDEITTIEGLADGDTLHPMQEAWIEYDVAQCGYCQPGQIMAAVALVKRAQA
EGFSIDDEALDEIRNICRCGTYNRIREAIKAGADNM
>A0A240C2C9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia ficaria|TrEMBL
MMTLTVNDQPLSFDGDPHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAVGKKITTIEAIGATPAGKAVQEAWVDLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMSGNVCRCATYVRIRAAIHQAAKALD
>A0A5E7GH38|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSDTSSSVAMLSRRGLLKGGALLGGLVVSTYLPPMVSRSFAADVVKSANMGDNAQKGYGA
FVRIDHAGAVTVISPKIEMGQGIQTGIAMMVAEELEVPLSQVTIAEAPPNAALYTDPLLT
FQATGGSTSTRYTWEPLRRAGAGARVLLIQAAALRWNVAPSQCRAQNGRVLGPHNRSAGY
GELVDAAALLPLPTDVPLKPVAEFKLLGKPAQRLDTPHKVNGTAKFTIDLHVPGMLIAST
ITCPVSGGKLLALENEEAARNVQGVRDIVRLDNAVAVTATNFWACQLALKALKIEWDMGP
HAGLDSAHLDKSLFDASAGDGVFAHRAGDIDSAMKNAFSRFEAIYEQPFLSHSPLEPMTC
VAHVRADECELWVGCQAPGLAQMGAAKVCGLPTDKVVIHNQLIGGGFGRRLESDFIFQAV
DIARQLSYPIKLIWSREEDMTHDRYRPHYVDRLNAALDKDLRPVGWEHRIAGASVVAAYL
GGLPPDGVDFDAVEVAKDPVYSLANLQVRYIRHDPEVIPVSWWRGVGPLRSTYAVECFID
ELAHNAKVDPVQYRLDLMQSQPRAQAVLRKAAQLVGWGDALPAGSGRGVAVSAVFGSFVA
TVVELERQGDKGLHIKRLVTVIDCGFANNPTSVASQMEGGTLFGLSAALFNEILIEKGQV
QQTNFHEYRQIRMSDAPPVQVHIVNSVESPGGVGETGAVPAAAALVNALYAATGVRERRL
PLSRNGYFTV
>A0A5E7MCB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MMPTAKSRRQIARPHNLQKYAGVPMITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKF
GCGMGLCGACTIHIEGAPARSCITPIGSVVGQNVTTIDNLHVDPVGQVVQQAWLDSAVAQ
CGFCQGGQIMSATALLKTNPNPSDAQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEGKA
>A0A5E6UXU8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVSTIDNLHADPVGKVVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEVKA
>A0A5E7HGN0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A5E7H9N0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVIGQNVTTIDNLHADPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKIHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A448BM92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSKIDLSNALPGSRRGFLKGAAVVGLTIGFQWSGARRALAAALPDAGFAPNAFLRIAPD
DSVTVIAKHVEMGQGAYTGIATIVAEELDADWSKVRVESAPADAKRYANLAFGTMQGTGG
SSAMANSWMQLREAGAKARAMLVEAAARRWRVPATELRTRDGFVEHPASQRKASYGSLAA
AAAELPVPEKVQLKDPKDFRLIGHQAPRVDVPGKTDGSAQFTLDVSLPGMLVALLQRPPL
FGATVKSFDATATRAIPGVVEVVQVPHGVAVVAKGFWAAKQGRDALKVEWDESKAEKRGS
EALMAEYRKLAEQPGKPARRDGDAAKAVAGATRRIAASYEFPFLAHAPMEPLDAVVRLIA
DSCEIWAGDQFQTVDQGNAARTAGLKPEQVKINTLYAGGSFGRRANAWSDYIVEAVSIAK
ALGANGVPVKLQWTREDDIHGGFYRPMYYHRLEAGLDADGKMVGWQHRIVGQSILEGTPF
AAVMVKDGIDATSVEGAANLPYAVPNVSVELSTTQVGVPVLWWRVVGSSHTVYAVEAFID
EAAQAAGKDPYLFRRDLLAEQPRLRGVLELAAEKAGWDPSRPLPAGRGRGIAVTEAFKTF
VAQVVEVSVDKDGKLKVERVVCAVDCGIPINPDVIAAQMEGGIGFGLGAILHSAITLKDG
KVEQNNFDGYQVLRIAEMPKVEVHIVPSGEAPTGVGEPGVAPIGPALANAIFAATGQRLY
NLPFPTSFAKA
>A0A5E7I2B2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MMNSQINLARRVFLKQTATVTGGLAIAFYLPSGLAATDPKAPASTGEFEPNAWVRILPDG
TVKLVVHKHDSGTGTHTALAACVAEELGVNPMTVQVISPEDPFFETYIHPIWKVFSTGGS
TSVSLEYDRLRMAGATARALLITAAARQWKVSPDSCSTDEGRVVHLASKRSLGYGELAGV
AAHLPAPAKVTLKDPAQFQYIGKLRHKRDAQAKVCGRFKYSIDVELPDMLVAVIQRTPVV
GAKVLSVDAAATLQVPGVRKVLAVPGRPDVLGGNVEGVAVLADNYWAAHQGRALLKVQWS
ESPLAGFDSDELVKAQLAALDDKGAQRVSAMAAGDVRAQWPVAAKLLEADYRMPYKVQNP
LEPICITAQVKDNAITYWGGVQVPSSALEAAQTVCKIAKDNVTINEMVSGGSFGAREAKY
WLFEVAYLAQQAKVPVKLMNSREDEMRSLFMHPATLHRVKGALDKQGRLTALQLNAVSPA
SPEQWEPGYFERPDKMDYSTTEAITAWDFAYRPANLDLVWVKHESDVPSGWYRSVSFIPN
VFAVESFMDELANGAGQDPLAFRLAHMHDRPRHVAVLKSAAERAGWGQPLPEGTALGIAT
NQGYTSFIAVVARLSMQDGAIKVDKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGNALFDQ
LDIKQGRVVQSNFHDYRVPRMSDMPAVDILLVDGEPAKPGGVGELGSPPVAPAIANALFS
LTGVRQRSTPLSLG
>A0A7W6LUH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium scionense|TrEMBL
MTDVQGAKRGVRMTRRRMILGGSLIGGALVVGYTATHPMQVGGAILSGGGPDPEPSAFGS
FIRIAPDGWVTIVNKQQELGQGIHAGIAAIVAEELDADWDRVRVIDSRSNFRTYGVQGTA
GSNSIASNWDAMRNAGAAARAMFVDAAALRWKVPRRLIEVRDGVVSHPASNRSASFADLL
ADASRHTPPQSPALKQAKDYRLIGTDRVRRKDSQPKSTGAQVYTQDIQRPGMLVGMVAHS
PRFGGKLARYDASDARKIKGVIDAFAIETGVAVVAESTFAAKLGRDALRIEWDDSEAEKR
STPELLRYYHDIATGRGDVDPSDFGTKGENPEAPFTGEVVEFAFNFPYLAHAPMETLDCV
AKVDGWNVSITSGAHLPIVDQVQAARVALTIPGKVDIEVVPAGGSFGRRGLMASDYVIES
VRIAKRTEGRPVKLIWTREDEMMSGYFRPMSHHRAWIQLGADGFPARWRIHAVCQPLMPI
GGNPQATEGITDSPYFSTASTVDGKAFSPRFPVPVSFWRSVGHSHTGMVMEHIVDQLARR
AGRDPAAYRRSLYQKAGATRRIAVLDMLCSKAGWGKPLETGWARGLAVHEAFGTIVGQIA
EVRMSEGRPIVRRVFAVVDCGIAISPDLIAAQMEGGIGFGLSAALYGAVTLKDGIVQETN
FDSYPVLRMNEMPAVETYIIPSTNRPSGMGEPGVPPIAPAVANAILTLTGSPTRSLPFVH
GGAANAGFSNAGSAIFGR
>A0A7W8M8Z3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Quisquiliibacterium transsilvanicum|TrEMBL
MTTIKLNGKAVEVKAEADTPLLWVLRGELALTGTKYGCGTGLCGACTVHLDGAPARACVT
PLSAVGGAEVTTIEGLAGPEAKALTEAWIDVDVVQCGYCQPGQLMSASALLRQTPQPTDA
QIDEAMSGNICRCGTYPRIREAIHQAAKAKAG
>A0A2W0C3L5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paenibacillus illinoisensis|TrEMBL
MPEYRIIVDLSDHMLYLLDGDQVIKGYPVATGKMLTQTPKGEFTIVNKQPNPGGPFGVLW
MGLSEPHYGIHGTNEPSSIGKSVSHGCIRMYNPDVLDLSSKVSVGTRVTIRP
>B9AYK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD1|TrEMBL
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCV
MPAVAVQGRKVTTIEGLSPDGRHPLQLAWVAEDVPQCGYCQPGQLMQAAALLNGGRPVDD
AAIVSAMSGNVCRCGTYARIHRAIKRAASGDPALDAVAGDAKEA
>A0A161X276|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. W74|TrEMBL
MSVLSSRRGFLKGAAASAAAVLVIGVAPSGSMAAANAADTTMLNPFVKIAADGTVTAIVK
HFEKGQGPATGLTTLIAEELGVSMDAIEYEFAPSNPKLYNNTAFGPIQGTGGSTAMFNSF
KQYRQAGAAAREVLLQAASLAWDVPAAQLKLEDGVISGGGNKAPIGEFVAAASKLTAPEN
PRLKDPSEFKLIGNASVRRKDTPPKINGTAKYAMDIQLDNQMVVTIKRATRKGATVTSFD
DSAAKDVKGFIRAATLPNKAGVAVYAENTWASLQAREALEVTWDNSAAESRSSEDVYKEL
MAALNTVPEYNLTKNDQAEIAGAIENADKVVEETFYFPLLAHAPMEPLTCTIEATEDGGV
ILHDGCQMPTSPHAAIAQILQVPMDKVQVNTMFAGGSFGRRATPTVDYQVEAALSFVMTD
RRRPVKLVWSREDDITGGYYRPAFAHKVRVGLDADGNIAGWDHRVAGQSISKGTPFEAFS
VHDGVDHLSVEGVTPTQYSIPGMFAGLTDIKPATTVLWWRSVGHTHTAYVMEAMMDAVAT
AAGRDPVEFRLAHLAGDTPDQKRLTGVLKLAAEKSNWGKGAEGRSQGVAVHKSFGSYVAE
VVEISGDAENGVKIEKVTCAVDCGIPVNPDVIKAQMEGGIGYGLGHAMRDEITLENGEVI
QQNFPDYEPLRIGDIGEIETHIVLSTQAPTGVGEPGTPPSGPALANAIAAKGPRVTELPM
TKAGVTFA
>A0A840FN20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax guangxiensis|TrEMBL
MTTTLTVNGKAVTVNAEPDTPLLWVLRGEMRLVGTKFGCGKALCGACTVHLDGEAVRSCV
TPLEAVGSREVTTIEGLNGKEADALLQAWAEVDVVQCGYCQSGQLMSACALLKKTPKPGD
DDISSAMSGNICRCGTYPRIRAAIHIAAQKASR
>A0A1S7REA4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Agrobacterium tumefaciens str. CFBP 5621|TrEMBL
MRFTYTLTINDERRTFTASPRMPLLWALRDLLALTGTKFGCGIAQCGACTVHLDGRAVRS
CVLPVGEVGDGKITTIEAVGRTDNGEKVQRAWMEIEVPQCGYCQPGQIMEAVALLNERPA
PTDFEIDAAMSGNLCRCGTYPRIREAIKLAATGKTDVMRTLIGFSTHSEMKEP
>A0A3S4LIZ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chromobacterium violaceum|TrEMBL
MPGLCPEREGGQGRGGRGQERHPRPNAFVRIEKDGGVTIVSNKSEMGQGIYTSLAMLIAE
ELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLSSYDQYRKIGAAARDMLILAAAQ
RWRVPASQCRAENSRVFNNANGASLGYGELTEAAGKLPVPDTVELKPRHRWKLLGTRVHR
VDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPKGFNADAARAVPGVRDVFAISNG
VAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRADYRARAATPGQTYRSEGDAEAAL
AGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCEIWSGTQSQTLDAGMAAAMAGLKPE
QVSLHTTLLGGGFGRRAVPAGPTG
>A0A840MUZ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Afipia massiliensis|TrEMBL
MAAFVLKINGGEHRVDVDPQTPLLWAIRDGAGLMGTKYGCGVAQCGACTVHVDGQPVRSC
SLPVSAVGASEIITIEGIKSREAQAVQKAWVALDVPQCGYCQSGQVMSAASLLSLNPKPT
DEDIDLAMTGNICRCATYVRIRAAIHDAAKSLEG
>A0A644XR33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bioreactor metagenome|TrEMBL
MSSIFEAPTLPVELNRRSLLKVGTATVFMLAVTARGVVYAQDAAKKYGADSMPGGTVDDP
LVFVKIATDGTVTITAHRVEMGTGVRTSLPMVVADEMEADWARVKIVQADGDEARYGNQN
VDGSRSVRHFLAPMRRVGAAARQMLEGAAAARWSVPVGEVKAVNHEVLHAKTGRKIGYGE
LAEDAAKQPVPAADQRQLKKESEFRYIGKDKVRAVDLEDIGRGRAKYGIDPHMPGMVFAV
IARPAVLGAKVKSVNSDAALKVPGVLKVVEIPAYSGSPAFQPLGGVAVVASNTWAAMQGR
KALVIEWGESDNAVYDSASYRKAMEKAAREPGKQVRNSGDVAAAWSKADEKRRVTAEYYI
PHHAHASMEPPSATVLIDGDKCDIWACVQDPQNARDGVVKQLGMSADKVAMHPQLLGGAF
GRKSKADFVTEAAIIAKAMPGKPVKVVWTREDDIQHDFYHAVSLEHLEAALGADGMPVSW
LHRTVAPTISSLFNSAAQGESASELGMGAVNLPWQIPNFRVETGNVPAHTRIGWFRSVYN
IPHAFATQCFIAELAHRAGKDHKEYALKLIGPARKLNPQKAFEDGWNYSESPEIYPFDTG
RLRDVIEAACKGAKWGRKLPKGRGLGLAFSYSFLTYAATVIEVEVNDKGEVRLIAADMAL
DCGPQITPERIRAQMEGSVIMGQSIALKSEITFEKGAAVQSNYNTFEVARHNEAPPVVRT
HLVNNHLQTPPGGVGEPPLPPVAPAIANAIFAATGKRVRDLPIRSVG
>S9S617|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Litoreibacter arenae DSM 19593|TrEMBL
MKLTVNGQTHDVDVPPDMPLLWVLRDELQITGVKYGCGIAQCGACTVHVDGEAVRSCQIP
VGDLEGEVTTIEGLGTPDALHAVQEAWIELQVAQCGYCQSGQMTQAASLLADNPAPSDAD
IDDAMSGNLCRCGTYPRIRAAVKSAAAKMGA
>A0A6M4GXR4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MTTSVKNASRRKFLQSSGALSGALVIAFYLPMGGRAYAQAPKMVYPPNAFLRIGKDNTVT
VIVKHLEFGQGVQTSLPMLICEELECDWTKVKAELAPADPVYGNIFWGGMQGTGGSSSVA
NSFDQLRLVGAQARTMLIQAAATQWKLKPEELKADKGFVTGPGGKKASFGSLADAAMKLP
IPQDVKLKDPKDWKLIGKPTRRLDAPDKVDGKAVFGIDVKRPNLHTAVVMHPPVFGAQVK
SFNVDKVKAVSGVTHVIEIASGVAVVGKGYWAAKSGRDVLEVEWDIPRTASTLSTERLRA
DYRDLAGKPGGAVAKKADNPEAIKGAVRTISAEYEFPFLAHAAMEPLNCTVELRADGAEI
WAGTQMPGVDQAAAAKVFGFKPEQVKVNTLTAGGGFGRRANPNSDWIIDACEIAKGAQVP
VKLVWSREDDIRGGYYRPMYVHRADIGLDAQGNIVGWNHVVVGQSILTGTPFEAFAVKDG
VDGTSVEGVPDTKYDIPNLAVTLRSVGLPVPPLWWRSVGHTHTGFVMETLIDEIAAASKQ
DPVAFRRKLLAKDPRFVKVLDLAAEKAGWGSPLPAGRARGVAIVESFGTICAQVAEVSLE
NGAPKVHRVTAAIDCGPVVNPMTVEAQVQSAIAYGLGAVLYSELTLKDGGVQQSNFHDYR
VLRLSDMPQVSVFTVPGGTKVSGVGEPGTPPIGPAVANALAALTGKRARVLPLANMKWA
>A0A1X1PBL8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia puraquae|TrEMBL
MRIRTAVRLANTDTPTLDASPVAGAGSPMLGRRDFLKLTMAASGCLALGIAPTRASAEAG
RPLLTSPPQAFLIIEPDNTVTVAVNRTESGQGVSTALPMALADELDADWHNVRTVLAPAG
EPYKDPVTGIQMTGGSTSINHSFTQYRELGASARAMLVAAAARRWNVDPATCRTAHGVVT
SGSHSATYGELAPDAMAMPVPQHVPLKSPDQFRIIGKPTPRVESRAVLDGTLKYGMDWRL
PDMMVAVVARPPRFGGQVASYNAAAARAVKGVVEVVEIPTDRGGTGVAVIANGYWPAKLG
RDALQVTWKDTGSTVTSAEQMQAYKQLAGTPGTVVRTADAGNAPPAATRIRKDYEFPYLA
HAPMEPLSCTVDVGPPSCACGIKIWGGSAMQTTDRAAVAKALGVAPGKVQIFTMMSGGDY
GRRSTPTSDYVVEAARVSAAYLAAGHLGPVKTIWTREDDLRGGYYRPMVLHRVDIGVDGS
GAVRDWQHVVVGQSVLKGSPLERTTIRKSGTDPDLTEGVANSPYGFPMRVSVHQPDVDVP
VQSWRSGGNTHTAFVMETLVDELAHSARQDPVAYRMARLSGPEHTHHRQALALAVDKSGY
GTRRLPAGHAWGVAMHETAGTVVAYVTEVSIEAQQPRVHRVTAGVHAGRIVNPTGAEAQI
QGGALFGLATTKPGFAIDVEHGAVRNAGFADYSPVRMQEAAPVDVFFVPSDAHPTGLSEA
GVPPIAPAVANGAFVLTGERLHALPFAPMLVASNAPVLPAATAAEDDPYADLPAGGCRMP
RKAKTAALKPKVSQSQAGVGQGNAVPRFLRPKRRAGIPCVDDLKKPTTT
>A0A346B8Y5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinilytica|TrEMBL
MTTFNINGQTHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDRKITTIEAVGSTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLIASNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIRQAAKGA
>A0A292ZK52|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium fuliginis (strain ATCC 27551)|TrEMBL
MTKFTVNDRPVQYRMDPATPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCQV
TIAATEGKFVTTIEGLSPDRGHPLQQVFAADNVSQCGYCIPGVIMAASVLLRRTSDPGDE
EIDAAITNICRCGIYPRLRGAIQRAGRVMRGEEVVDAVPPSGITPDEAAKAVPALRKP
>A0A6J5D769|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia paludis|TrEMBL
MSRGLIEAGRAGAGVSRRSFLKLGMSLGAAAGGGLLLGFSLPAAGDDARRSVIGGDAAEP
AQAGVFAPNAFVQIDRAGKVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
EKLFLDPLLGGQLTGGSTSIRYAWEPLRRAGATARTLLVAAAAKQWKVDPAACRAANGEV
QHPPSGRRASYGQLADAAAKLPVPKDVVLKKPADFKLIGTPAKRLDSPEKVDGTAQFGLD
VRLPGMLYAVIVNSPVFGGTVAGVDDTAAKKIPGVRQVVRADNAVAVVGDHTWAAKRGAS
ALVVKWNEGAGAKVSTKDIVADLAQAATNGKGAVARKDGDVAKGFSNAKTRIDAVYEQPL
LAHATMEPVNCTVQVRSDGCEIWVGTQVPTRARDTVQQLTGLAPERIVVHNHLLGGGFGR
RLETDMIAQAVKIAKQVNAPVKVVWTREEDIQHDMYRPYYYDRISAGLDANGKPIAWQHR
IVGSSILARFAPPAFKDGVDPDAVEVAADLPYDLPNQLIDYVRQEPRHVPTAFWRGVGPT
RSTFVVESFIDELATQTRTDPVQYRRALLGKTPRALNVLDVATKAAGWGPSLPKGQGRGV
SVMHAFGSFFSIVVDVAVDNGEVQVKRVVCAVDCGMVVNPDTIEAQVQGGIIFGITGALY
GEITIEDGRVVQTNFTDYRMLRINETPPIEVHLVKSGEAPGGIGEPGTAATAAALSNAIF
AATGTRLRKLPVGDQLKTA
>Q08PS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stigmatella aurantiaca (strain DW4/3-1)|TrEMBL
MPVYSFTLNDKTVSVEAPPDMSLLWVLRDMLRVTGPKYGCGVGVCGACTSHLDGNAFRPC
IQPVSGVAGHQVTTIEGLGGETLHPVQQAWIDEDVAQCGFCQPGQIMTAVAFLRQNPHPT
DEAIDAAMSENVCRCGTYCRIRKAIQRVSR
>A0A0D6I7H1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MTRLQVNGQPKEVSVPDDMPLLWVLRDELGMTGTKFGCGMALCGACTTHLDGQPTRACVT
PVSAAAGRAISTIEGMAADPVGRTVQRAWVENNVAQCGYCQAGQIMTAVGLLKTTPAPTE
QQIDEAMSGNICRCGTYPRIRAAIQQAAAQLAQGGK
>A0A1E3EXJ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MPFQITINGTSHQVDADGDTPLLWVLRDVLGMTGTKFGCGMALCGACTVHLDDSAVRSCI
TTIDSIGDSKITTIEAVGNTPAGKKIQDAWLAHEVPQCGYCQSGQIMSASALLASKPKPT
DADIDDAMSGNICRCGTYVRIREAIKQAAQSGG
>A0A103DY49|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia singularis|TrEMBL
MISLNINGTTQTVDAPADMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PVAAVGDKKITTIEAVGATPAGQKIQQAWRELDVVQCGYCQSGQVMAAAALIASNPHPGD
ADIDAAMAGNICRCGTYNRIRAAIKHAAKEA
>A0A2N8NR24|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces eurocidicus|TrEMBL
MPSHSFTVNGRPVTVDAPDDLPLLWALRDLLGVRGPKYGCGIDVCKACTSHLDGEAVRPC
VVPVAAAAGREVTTIEGLADGDRLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKRTKNP
TDAELDAIANVCRCGTYFRIREAIRSAAEKMG
>A0A7W5MQV4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK345|TrEMBL
MAALTRRKLLISGGAGVGLVVAWAVWPRHYGAALPTAPGEAAFGAFLKIARDGQVIVAVP
QCEHGQGVYTTLAQIVADELGADWRTIGVEAAPLAPPYANPLGAAKLFTDAATHVPERVR
DELWTRDSLLVTAGSSSVRRFEQPLREAGAAARLLLCQAAAERWDADWQQCDTRAGFVTL
GDRRLRFAELAEAAAGGRVPDELPLRLGDEGRLSGESLPRLDSPAKVDGSSNFVADVRLP
DMVFASIRQGPQPGARLLSCDKAAAERVRGLLSVVTTDHWVAAVANNWWSANQGVAALAP
RFTRGGAMVDDAAIERALDAALNRAGEPVARIGDAAAALRGAGVIAAEYSVRPALHAALE
TPAATAHWRDGRLELWLATQAPTLARAAAAAAVQLSERDVIVHAMQVGGSFGAALEHDVA
AQAAVLARALRRPVQLCWSRGEALLQDRVRAPAKARMRARLGPRGTILAWHAAIAAPPTG
RALGERLLAGDPLRRLAAALPAGTDRYATAGAVPPYRLPALAVDHHPVALDLATGHLRGG
ADGYTAFFTECFVDELARAAGSEPMSYRVGLLGGDARLARCLTTAAELGGWSGGVPGSGQ
GIACHRMAGSAIAVLAEAEVGEGGAARVSRLVAAVDAGRAINPDVVRQQIEGGLVFGVAA
ATGTAAGYKDDLATVRHLGALDLPTLATAPEISVELIASGADCGGISDLGVPAVAPAVAN
ALFAAAGTRRRVLPLRSS
>R4YPA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Oleispira antarctica RB-8|TrEMBL
MTSSTSDVSTSAFAELKQSRRTFLKATAMGSGGLMMSIALPGCATLKNGGISQVGDNEQW
DSNAWLRIDSDNSIHFVLDRVEMGQGTYTGMTSLLCEELEVDPETVNVSFAGVDSVYRNT
IYGIQITGGSTSVASSWQIVREAGAATRIMLIKAAANTWNINTSDCMAENGAVINKAAGH
ESHGQKITFGQLAVIAATYSVPSDIPLKDKADFKIIGKYNKRLDALKKATGTADYGIDTE
LPGMKYAVFTRAPRWDSQIKRFDASQIENMPGIEQVFAVNKSSTIGVAIVAKSYWQARKA
QQALSVEWHESELTQVDDASIFAQYKKDLAADSGENVRSEGDIESALENAEQTISAEYEM
PFLAHASLEPQNCTAWAKPEGLEIWAPTQSPDMAQVAAAKVTDYSLSDIKINTTFIGGSF
GRRINQDFVAEAAAISEISQQPIKLIWSREEDTQRDWYRPSSYHKLSASLNKSGEITGWN
HQMAGSGVFDYFVGDAAPAQYPFMPKFMFGMLESAGKLGEGIIAPADGSIFEGANGIPYD
FANINVDYKKSDSGILVGNWRSVGYSHNGFIVETFMEQLAQLPAMKAKKDSYQFRYDLLK
QHPRAQAVLKMAADKAHWGTPLPGCTQGISIHKSFGTWVAEVADVMVEDNKINVKRIVCA
VDCGQVVNPDTVVAQMEGGIIFALTAALYGKITIKDGIPQQTNFHDYQLLRINEAPQIDV
HIIASNEKPTGVGEPGVPPLASAVANAITAKTGQYFYSLPLTLG
>A0A0M7BTS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MTTTMHVSRRGFLKGGLGALTLAVTGNGLVSAVWAADEPKKYGADSMPGGTVDDPLAFVS
IAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEAAWDRVRVVQADADEARYGNQNVDGSR
SVRHFLMPMRRVGAAARQMLEAAAAARWSVPLAEVRATQHEVVHAPSGRRLGYGELAADA
AKLPVPAGDTVKLKTRAEFRYIGKDEVRLVDLEAIGKGEAMYGMDMRLPGMVYAVVARPP
VVGGKLRRVDSAKALAVPGVLKVVEIPAMAGAPAFQPLGGVAVVASNTWAAMQGRAALAI
EWDDGPNAAYDSVAYRETLTEASRKPGKVVRDQGDAPQAWAKAGETERFMAEYHVPHLAH
ASMETPVATVRIQDGAAEVWTSVQNPAAAQEAVAKRLKLKPENVKVHVLLLGGGFGRKSK
PDYVDEAAIVAQAMPAGTPVKLVWTREDDIHHDYLHTVSAEHLEAVVGKDGKVQSWLHRS
AAPTIASLFTEGAKGEQLFESAMSAINMPYVIPNVRVETAEVAAHARIGWFRSVANIPHA
FAAQCFIAELAHRAGQDHKQYALDLIGPARRIDPGTLADTWNYSESPERYPYDTGRLRGV
IEAAASGAKWGRELPKGHGLGLAFCYSFMSYTATVVEVAVDEKGEVRVVAVDMALDCGPQ
IKPERIRAQMEGGAIMGLSLALLGEISFEKGRVKQNNFYDYEVLRHNASPRVIRTHLVND
DHALPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRSVA
>W6V8Z8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. (strain GM41(2012))|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PATAVAHGQKILTIEGLSTDGSHLVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A3G7TPJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MELRINQKTCQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIETDAVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTAAPSDA
QIDAAMVNLCRCGTYNAIRTAVHDLAAQPAKKESA
>A0A3G7TPK5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MNKPIDSAEDLLGLPLNEPINLSRRRFLTGTAVGALVLGFGLPLGSARVLAATATAAERG
TQVPAFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFVVEAAPPGEAYVM
MENGMRITGGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPLAELSTEPGRVLHAASG
RSLGYGELAGRALDMPVPDPASITLRDPSQFRWIGKPVRRVDAYEKSTGKALYSIDLKVD
GMLHAAVQHAPRLGMTVGSLRNEAQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEAIQ
VDWLEAAADSKVRTMPADFSSDGFRDFLAAQQGPARDDENEGDVAAALASAKTRVEATYH
NQYLNHAQLEPPSALARYNPDGSLEVWLPNQAPDMFRDDIARRTGLAPAQIILHSPLLGG
FFGRHFLYDSANPYPQAIALAKAVGRPVKLIWSREEEFVRDALRPVAVVKFRAALDAEGL
PVAIEAVSATEGPTEAIAGKQGEKLDPSALEGLSGKSYAIANKRIAQIYVKGPVMLGYWR
SVGNSLNDFFYEAFLDELADKGGRDPYELRQHLLRDNPRLTTLLQAVGELSGGWKRGPFT
AEDGSRRARGVAMASPFGSHTAAVAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVNG
AVALGLSQALVEEAVYVDGKPRARNYDLYPILPPSRMARVHVRIVESGEKMGGIGEPPLP
AVAPAVANAVARLTGQRIRSLPLSRYTFS
>A0A3G7HEB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MNDLPLTRRRLLQAGGLIMISTLLPKSLLATAEILNSSALPADPTPDHVDSFIALDADGR
VTAFCGHVDLGTGVRTALAQIVADELDVDFEQVRMILGDTASTPDQGPTIASATLQVSAL
PLRQAAAQLRQWLLEGAAEILDQPIAGLRVERGQIYASARPTRRLSYAELARGQDLHLPL
DPRVELKAVGAGRYVGQSTPRVDIPAKVSGQLTYVHDLRLDGMLHGRVVRPPYPGADASA
PLGHALIAVDAASIAHLPGIVKLVVIGDFVGIVTEREEQAIDAMRQLKVQWQPWDALPDL
RPDILRETLLAHPKQERVLRDDPDFDSSLGTLNSPLNVDYVWPYHLHASIGPSCAVAMID
AERAEVWTGSQNPHDLRKDIALLLGRAPQQVQVNRMEASGCYGRNCADDVAADAALLSQA
VGRPVRVQLMREQEAGWEPKGTAQLMQVRGGLDGKREVAAYELKTCYPSNNARTLALLLT
GRVANRPDIQQMGDRTAIPQYRFPQMRVVCQDAAPIVRASWMRGVSALPNVFAHESWIDE
LAYIAQQDPIAFRLRYLDDPRALALIAALKKQAGWQDGSAHRHPAPPSQEWVKGRGFAYA
RYFHSKFPGFGAAWAAWVCDLSVNRRTGQIRLDKIFVSHDCGRMVNPAGVRHQVHGNIVQ
SCSRVLKEYVSFDRSGSTSLEWGGYPILRFDELPEVDVQLLDRPEEPSMGAGESASVPSA
AAIANAIFDAVGVRLRQVPFTPERVLQALQRAPDTDRPGQEARP
>A0A839P9Q1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. RMAD-H1|TrEMBL
MARLIINGTPHDIEVDPETPLLWVIREQIGLTGTKYGCGVAACGACTIHIDGAATRSCAL
PVSAVGPDQQITTIEGLSPDSSHPLQQAWLALDVPQCGYCQAGMIMAAAGLLTQNPNPTD
EDINSEITNICRCGTYNRVRAAIKLAANGGETTQRG
>A0A7W5FV53|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia violacea|TrEMBL
MRKEWMKQDAVVVGESGAVSRRSFMKAGALAGSGLVLGFFISGGNRFARAAETAKPVYQP
NAFLQIAPDNTVTVQVNRLEFGQGVHTALPMLIAEELDVDWRQMRGALAPAAEAYKDPAF
GIQMTGGSGTVAHSWNQYREIGAKARLMLIAAAAEQWKVDPAQVKTSKGMLLGPNGQKSS
YGAVADAAMKQPMPEKVTLKEAKDFKIIGKPTPRLDARAKSSGQQQFGMDFKPEGCKVAV
VARPPVFGAKVAKFDASKAKAIPGVVDVVQVPTDRGGSGVAVIANGYWPAKQGREALEIE
WDSSGVEKVSSDKQLAEYKELSAKAGLSAKKADTSKLASAPKKISAVYEFPYLAHAPMEP
LNCVVDLKADSCTVWAGSQFQTMDQAAAARTAGLKPEQVTLHTMMAGGGFGRRAVPTSDY
IVEAVNVAKAYKASGKAGPVKVIWSREDDIKGGYYRPSHVHRAELGLDAKGQIVGWNHVI
VGQSILTGTPFEQFMIKDGIDATMVEGMGDPYDVPLNLSVHNVKANVPVLWWRSVGSTHT
AFVMETLIDEAAHAAGADPVAYRKKLIDPKHKRHHAALDLAVAKSGYGKKALPKGQAWGV
ALHESFNTVAAYVVVASVKDGVPKLHKVTAAVHCNQPVNPLTIEAQIQGAILMAVGTTLP
GAAITLKDGVVEQSQLADYAIARMPDMPKVEVHIVPSTEPPTGMGEPGLPPLAPAFANAV
FKLTGKRLRKLPFDLATA
>F8GXB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MPQLQVNGQAKDINAPDDMPLLWVLRDELGMTGTKFGCGMALCGACTVHLDNTPVRACVT
PVSAAYGHAISTIEAMEADRVGRLVQRAWVEHNVAQCGYCQAGQIMAAVTLLKATPAPTE
EQIDEAMSGNICRCGTYPRIRAAIKQAASQLSRGAR
>A0A2R8BNU8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Defluviimonas aquaemixtae|TrEMBL
MKAKFTVNGAGREIDVPEDMPLLWVLRDGLGLMGTKYGCGIAQCGACTVHMDGIAVRACQ
VEARELNGVEITTIEGLGTPDSLHPVQEAWIERQVAQCGYCQSGQIMQAASLLAMNSDPS
DEDIDAVMSGNLCRCGTYPRIREAVHAAAEKMRS
>A0A7W6JSH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kyeonggiensis|TrEMBL
MTRFTVNNQPVAYKMDPRTPLLWALRDASNLTGTKYGCGTGDCGACTVDVDGTARLACQE
TIGALEGTFVTTIEGLSKDRSHPVQQAFIAANVPQCGYCIPGVVMAASVLLRANRNPSEA
DIKDAIPNLCRCGIYPRLIEAVQNAARIARGDAPAPEPGQDAPTPAQSEP
>A0A8I2BZ79|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MNKHVKNLAPETTDLSRRSFLVGTAATGLVLGYAASGIDQALAAPATANFEPSVWYSIAP
DGLVTVTCGKADMGQHVASTMAQIVAEELGANWKDMRVQLASNDPKFNDPVLGAQITGGS
WSTMMNFDAMSRAGAAGRIALTEAAAASMGVPAAELVVRDSRISHPKSKKSMSFAEVVKS
GKATKTFTADDLKAIKLKTPDQYTMIGVSVPQLDIPSKVNGTAKYGIDVMVPGMVYGALV
TPPVRYGATVKSVDDSAAKKLPGFIKAVTLDDKTTTTTGWVVAVANTYAQAKKAAAALKI
SYDGGPNAKLSSESLFAEAKRLQGLSDSGEFFVKDGDPNAAYGSAAKVLEAEYTTNINIH
APMEPMNATAEFKGDILHIYSGNQFATRSGAIAAGAAGIDPKFVVMHQMWLGGGFGRRLD
ADMMVPAVQAAKAVGKPVKVIYSRENDMTMDFSRPLTCQKIKAGMDGDGKIVALSHDVVS
AWPTQRWGIPDFLTPSVDKKGPLDSFTVNGADFFYTVPNHYVRAIKNEMAHNATPSGQLR
SVAPGWTFWAVESMIDEIAHATGKDPAQLRISLLDGKGKNDGGAQRLRNTLLAAMGLAGY
GTKQLPKGEGMGVACVSSQERATASWTACVAHVAVAPSGEVTVKKLTVATDVGTQVNPDG
IRAQVEGAALWGMSLALFEKATLKDGGIEQTNFDSYTPLRMSQLPEVAVNVIANGEKATG
VGEPAVTVVAPAIGNAVFNAVGARVRGLPITAEAVKAAMKA
>A0A3M2RMA6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter litoralis|TrEMBL
MATEFELNGQPVTVDIENDTPLLWALRDDLDLTGTKYGCGIGMCGACTVLVNGRATRSCI
TPVAAVSGATITTIEGLHPDGQHPLQKAWIETQTPQCGYCQSGQIMQAAAMLKDFPNPTD
EQINNAMGGNLCRCMAYVRIRKAIKMAAKEMNTSGNTAQETGAAANE
>A0A7W8P8J8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. HC6.4b|TrEMBL
MAVLNINGRKVKVDADPDMPLLWVLRCDLGMTGTKFGCGVGICGACTINLDDAACFACQT
LMSSLHTQKITTIEGLQGREAQALKAAWIELDVVQCGYCQSAQLMAACALLKHKPDPTDA
DIDEAMTPVVCRCGTYPRVRAAIHQAAAKVRKS
>A0A2N9CRN3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MNRSELLARTGCLTVIRPPAPPVKPAPGQPGSLSSYVPALPEVFVAILDDGRILAFNGHV
DLGTGIRTSLAQIVAEELDVPAARVTMVLGDTAATPNQGPTIASATIQIAATPLRCAAAQ
ARHALLALAAERFGVDTARLDIDDGTISAEGHTITFAALVAARRIALTLDLNARTKDPAR
YRIVGRASPRVDLPAKATGQLTFVHDMRVPGMLHGRVVRPLYAGHDSGPFVGTSLLDVDR
ASVADVPGLVAVVVLGDFVGVVAEREEQAIRAARQLRVTWRPLPALPPLDEPAAAIAAAP
ARRRVLLDEGDVGAARTEPDTLTLSRTYAWPFQMHGSIGPSCALADYRAPGDGRITVWSG
TQNPVSLRYDLATLVARDEADVDIVRMEAAGCYGRNGADDVCGDALLLSRAVGRPVRVQL
SRADEHLWEPKGAGQSMQVTGTVTRDGRLLGYDFTTRYPSNDAPLLAALLTGAIAPEPRV
FEMGDRTAVSPYASPHRRFVCEDLAPLVRASWLRGVSALPNSFAHDAFVDECAALTGVDP
LAFRLRHLQDLRATELLQAVADRVGWTPRAPRPTNEREERDASRLVHGRGIAYARYVHSR
FPGFGAAWSAWIVDLSVDRVSGEIRIERVTVGQDTGTMINPDGVRHQIHGNVIQVLSRTL
KERVRFADGKVASREWASYPILTFAEVPDVDVVLMPRQGEPPLGAGESASVPGPAAVANA
LFDATGVRFYAPPFTPETVRAALREAGRLMSADAARAPVTAGAT
>A0A0P1G871|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter multivorans|TrEMBL
MTINTSRRGFLQGAAASGAALYIGATANGAMAASGSADAMLNNFVKIGADGRAIAICKHV
EFGQGSATGLTTLIAEELGVTMEQIDYEFAPSNPAIYNNLLFGPFQGTGGSTAIANSFPQ
YRNAGAAAREMLISAAAKEWGVEASALDIVEGMVTGAGKSAPMGEFVAAAAEMEVPAEPR
LRDASEWKLIGNAQTRRLDSPAKVNGTAMFAMDVQLDNQMVVMVRRTPQRGGTVVSFDDS
ASKEVKGFIMAQALPTGHGVAVYAENTWAAMQARNALEVEWDLSAAETRSSAEIKDEIMA
ALNTEPTYNVNKADRAAVKSSVDGAAQVIEKTFYFPLLAHAPMEPLNCTIEQTADGDIVL
HDGAQMPTGPHMAYQQIFELPAEKIQIKSMLAGGSFGRRATPDADYQVEAGLAFIMTDRS
RPVKLVWDREDDIRGGYYRPAAGHKVRVGLDENGTIVGWDHQVAGQSIMKGTAFESFAVH
DGIDHSTVEGIADSPYTIPGQALGLTDTEKATSVLWWRSVGHTHTAYVMEVMMDLAAKAA
GKDPVDFRLDYLAAEGDAARKAGVLKLAAEKAGWGNPAAGRAQGIAVHKSFGSYVAIVAE
ISGNNDDGIVIEKITAAVDCGIAVNPDTVVAQLEGAVGYGIGHAMRDQITLDGGAVEQSN
FPDYEPLRISDIKAIETHIVASAEAPTGMGEPGTPPSAPALANAIASLLDSSDMLAELPM
AEAGVYFA
>A0A7W6T5A5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. SBR1B|TrEMBL
MATVLTINGETKSFDAPPEMPLLWVLRDILGMTGTKFGCGIAQCGACTVHVDGKAVRSCV
LPVSAVENRAITTIEHVGSTPAGAKVQKAWLDLEVIQCGYCQSGQIMSAAALLAATPNPD
DSDIDAAMAGNICRCGTYVRIREAVKQAANGRQS
>A0A841L9Q5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polymorphobacter multimanifer|TrEMBL
MNALPLSRRQMLFAGALAGGGLWFGAGPAGAAQDGVAGSPGAGLTAFIRIMPDNRITIVS
QNPEIGQGIKTSIPMLIVEELDADWSQVTIEQALADQKIYGRQVAGGSMATTLLYDSMRR
TGAAARAMLVQAAATRLGVPVGELTTGSAMVRHAASNRSLSYGALAADAATLPLPDLKAV
TLKDPKAFRIVGKPMPGVDNMKVVTGAPLFGIDASVPGMKIAMFVKCPCYGGTVASANLD
AVKAIKGVRNAFIVAGNGDDYELAAGVAIIADTTWAAMKAREALQVEWAPGAGADQSSEG
FAKAAAALAGTRGPQEIFTEGDAAAAMPGAAKRLKASYHYPFLVHAPLEPMNCTARVDGD
KVELWAPTQNPEPGRASIAKLLGVAPEAVVIHMMRCGGGFGRRLTTEYMTEAAWIAREAK
VPVKLIWTREDDVTRGNLRPAGWHHLEAGLDADGKVTAWTNHFVSFGKEGKFGRAAAIET
TQFPARFVPNFRCDATVLDLAAPTNFLRAPANNGFGFVMQSFIDELAYLAGQDPVAFRRT
LLGTPRLVGPADKRDSYDAARALGVLDKAAAMAGWGRKLPKREGLGIAFHFSHLGYFAAA
MEVAVADAGDVKVKKVWAAGDVGRQIVNPSGAINQVQGSVIDAIGSAMGQAATLSGGAIE
QRNYDGFPIMRMPDTPPIEVAFVLSDHPPTGLGEPAYPATPPALANAIFAATGVRLRSLP
IDTELLKA
>A0A6J5EKK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia humisilvae|TrEMBL
MVKRRTFIVGGAATLGALVVGWSALPPRQRLMPSQPPGVQPGQTALNGWVKIGADNRVTV
MVCRAEMGQGVHTGLAMLVAEELDADWSRVGVEAAPVDRIYNNVESVISDLPFRPDDDSA
LKGLVAWLARKGARDVGAMMTGGSTSLNDAWLPMREAGATARAMLIEAAATQWGVPLEQC
HTEAGRVFDGPVSGATRSATYGELAPLAASQPLPRKVELKDPAAFRLIGKPLLRIEAPSK
LDGSARFGIDAAPDGLLYASVAMCPVLGGAVAHFDGAAAAAQPGVRSVFAVAPYHGGTGG
VAVIADNVFAAMQAAAIVKCAWHIDDDARVSSADVLQRLADALDDSAGHTWYARGDADAA
LGIAARVVKAEYRVPYLAHAALEPINCTAQVNDGAAIVWAATQVPDVARRITAQLLGLPD
DKVEVRQHLIGGAFGRRLEMDFIAQAVAIANTVRGTPVQTVWTRPQDMMHDFYRPACVSR
FSAGLNDAGAVIAWRNISASQSLVTSWLARNYGVPSFAAALGRAFDKTNDEGAFDQPYEW
LNVHVGHKPVALPVPVGFWRSVGHSHQAFFVESFIDELAAAARKDPISYRAAMLAHHPRH
LAVLRRVAQLAGWHAPLDNDERGLAQARGVALHEAFGSVVGQVVEVSVEADKARTIHVNR
VVCVIDCGLPVNPNLIAQQLEGAIVFGLSAALYEEITLEGGSVQQQYFSDYPVVRMEQCP
RILTDIMSSREHPQGVGEAATPPVAPAVANAIFALTGQRIRTLPLKLA
>A0A7W7HVT5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes digitatis|TrEMBL
MPEHSFRVNGTPVTVDVPGDVRLLWVLRDILGITGPKYGCGINVCKACTSHLNGRAVSPC
AIPVGDLGPDDEVTTIEGLAATAGAELHPMQQAWLDHDVVQCGYCQPGQIMAAVDLVRRV
AAEGRAVTDADLDGIRNVCRCGTYFRIRAAIRAGAAGMGSP
>A0A1B3P264|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Agrobacterium sp. RAC06|TrEMBL
MQYVLNGVIANVPSEWYDESLLFTLREHHGLVGAKFGCGVGICGACTVIIDRMATRSCQV
RTADLTPTTQVLTIEGLERNGKLHPVQDAWLAKAVPQCGYCQSGQIMSAVALLVDSNRAG
STMSLDAIVPAMNDNLCRCGTYQRIRDAISTLIENR
>A0A128FBW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia marina|TrEMBL
MSVSVNINGQDFELDVPTDTPLLWAIRDNLKLTGTKFGCGLAQCGACTVHMGGQPIRSCV
TPVSAVAGQKITTIEGIESKASKAIQAAWEEIQVPQCGYCQSGQIMAASALLASNPSPTD
ADIDAAMNGNICRCATYVRIREAIKQAATELRQG
>A0A6J4UY16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thermomicrobiales bacterium|TrEMBL
MTVDDQFPSTVPHDRQVSRRRLLQTAGVAAGLTVAWSSREALGQDAVSSPEAGATPEATP
VSPPSPFSSEVDSYLRINPDGTVTLMTGKVEFGQGIRTGFAQLIAEELSIPFESVLVILG
QTDQTPFDLGTFGSLSMRLTGPRIRQSGAAMRVWLSELGAAQLGQDISAVSLSGGAVVVT
DDPTQMVSFADLAAGQATMRELDPEIAFKDPATYTVIGQSIPRPDVIEKVDGSLKYGIDG
TIEGMVWGKIVRPPSFGATLTSIDFTEAEVAPGVVGVFHDGNFAGLAAERYEQAEAAIMM
VQATWEELPATTTSENIHQVLLDTADEGVRLDETNVEPASDFDILAGITEPIELTFRGPF
VSHTPIEPRNSLVQITPERVDVMTSTQDPFGVRRSVAEVLGREPETVVVTPMATGGAFGA
KIVAMADVEAARLAQAFGRPVKVLWRRDEELAHGQYRPATLVSITTGLDGQGGIGGWLYN
LYSASYFPENVERSEDTQNGAASDWSANIHEIYEIPNAQTFWFHSASTLPPYFWRVNGAT
MNTFAREVTLDVLAEMEGVDPVAFRRNLLGGNPRMMAVMDAALAKAGWTPGVGSTGTGYG
IALGFDANSYVAEVARVEIDQNTGEVFVRHVDVAIDCGLVINPEAVKHQVEGSVVLGVSS
ALREIIKFEGGRVTNPSFAEYAPITMRESPTVDTVFVEDKSQPMSGVGEPAVAPVAGAIA
NAIYDLVGIRLYDLPFTADRVLAELQKQTGAATPVAVAAD
>A0A3S4PTH6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica|TrEMBL
MSTFTAVENISRRDVLKLFGAVGGGLALGASGLTWSPMALAQDKEARLNLFIAIGEDDKV
YLTCHRSEMGQGIRTGILQVLAEELEADWDKIVPIQGLADKRYASQNTDGSRSIRENYDR
MRQMGAMARTMLEQAAAARWKVPVSEVHTADHKVLHAKSGRSAKFGELALAASKQPVPAV
ESLTFKEVKDFKQIGASRQIVDMDAMLSGSAIYGYDIKLDGMLYASIMRPPVLGSDVASL
DDTAARKVAGVVGVYRLPAAKGAPAFQALGGVAVIATNTWSALEGRKALKATWTQPDNSQ
HDSSLYLKELVERVQQSGNVVRQAGDEIKNWPEANTLKAVYTVPYLIHSSIEPPVATAHV
TEKGCEIWASTQTPQSTQQNVAAALGMEEDTIKVNVTLLGGGFGRKSKPDFSVEAALLSK
QFKRPIKVSWSREDEIQNGYYHAISAQSYQALFDANNKPTALLARTGFPSISSTFAEGVE
YPSGGELDLGFVDVPFALPNLRYEAVKAQAHSRIGWMRSVCNIQHGFSVGSFVDEMAHRS
QVSCFEMWRSLLGEARRETFSDQGFKYGNYGEDLSRHPVDVSRYFGVIDAVEKAQAKAPK
AGKNQGWGFAVHRSFVSYVAVAMLVEVSEDKQLKVLNAIAAIDAGTIVNPDRVKAQTEGA
IVFGLSLALMGEITYKEGKVQQSNFHDYPLLRLPQTPDIEVVIIESDAAPAGVGEPGVPP
VAPSLTNAIFAATGQRIRDLPVSKLLRV
>E6PZ70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MRLTRRSFFELSAMAGGGFLLKLTLPQLASAQNHAANLLSPAAFVRIAPDGIVTIVAKSP
EIGQGIRTSLPMIIAEELDADWTSVRIEQANLDEAVYGSQGAGGSMSTPNNWLPMRQVGS
AARQLLVTAAARRWQVPESEVTTARGRLLHVSSNRSMGYGEVASDAAQLPPPDPATLHFK
DPKDYTILGHFQSGCDNLSLVTGKPLFGIDVYLPGMLHAAYHRCAVFGGRVKSANLDVIR
KLPGVRYAFVLDGTIQPATVVPVEAGLASGVAIVADSWYQAQQARKQLKVDWILPPNPVP
SSAELNNRAQALAAQPATHTLYSEGDVSKTLASANKVVEAAYSYPFLAHMTLEPQNATAW
FHDGKLEIWADSQNPGPGSRLVSQALQIPESEITIHMLRAGGGFGRRLMNDYVLEAAYIA
KQVPAPVKLLWSREDDFIHDAYRAAGWQFLKAGLDPAGEVIGWQQRLVTFGDGDHYAAGA
GIDAAEFPSGRVPNFELSTSTQPLWLRTGFLRAPGSNAYAFVIQSFIDELANAAGKDPLE
FQLALLSREASPGSPAAKHPDAPNTLKGKRQADVLRKVAEISDWANRSKTPGSGKGMGIA
AHFCHLGYFAIVAHVSVNASKGIRVEKVWAVGDVGSQLVNLSGAEAQVQGSVIEAMSHMQ
QEITLADGRIQQTAFDRDPMMRLRQTPKIEIGWVKSDYSPTGLGEPALPPVLPAIANAVF
AATGKRIRTLPLARSGFHFV
>A0A1J5REX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MDTDTRKDAEVSPARRGFTRRHFIEVSVLAGGGLLLAFELPVRERLAQAAALVSGTHGAG
PPGFAPNAYIRLTPDGVVTLWVAKSEMGQGVMTAMPMLLADEMDADWAAVRIEQAPSTPA
FGQQGTGGSTSVRQSWQPLRHAGATARAMLVAAAAAQWKVAPGDCHAKAGAVYGPHGQKA
GFGALAAAAARLPVPDQVKLKDPKDYTLIGKPVPRVDAAPKTNGQAVFGIDVQVPGMLVA
SVTQCPAFGGKLAHVDDRAARAIPGVHAVLPISSGVAVVANDFWTAKKGRDALKITWDLG
PNARLDDAAIAALLHKAAQEPGARAWKVGAGDAAVAAAQAAGGKLVEASYTLPFLAHATM
EPMNCTAHVQKDRCDIWAPTQAQTFNQGTASRITGLPEAAIHVHTTFLGGGFGRRFEQDF
VAQAVEISKAVARPVKVMWLREDDMRHDFYRPANLALMRAALGADGTLRAWSHKVVGPSI
MARVFPSRVRNGLDMGAVDGAVELPYALPNAETRYVMCNTPVPVGFWRSVGHSINGFTVE
SFMDEIAHAAGQDPYRFRRALLDRDKRALQTLDTAAAMAGWGKPLPAGHFHGIAMHRGFG
STVTQVAEVSVNPAGEVTVHRVSCAVDCGQVVNPNTVQAQMESAIVYGLSAALLDGIHLR
DGGVVQANFDTYRVLRIDATPHVDVRIIQSGEAPGGIGEPGTPPIAPAVTNAVFAATGRR
VRSLPIRAETLKT
>U2XPX1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MRLSFLTLIFVAFICGAEAEEKPNIVIFLADDLGYADLGFRGSDIQTPNLDRLASEGMVL
NRFYSLPICTPTRSALMTARDPIKLGTAYAGLQPWEHGGVSPEEHFMPESFRKAGYQTAM
IGKWHIGRQYESLVPHHRGFDHFFGHLNTQVDYYTHESAGGHDLQENGKSLKRDAYATDI
HGDESVRFLKELRDPAKPFLLYVPFLAPHSPMQAPEELEAKYKSRLNFPIPKRTYAAMVD
SMDQAIGRILDELERQGVSDNTIILFFSDNGGFAGFGGVNEPYRGGKLETFEGGIRVNAI
MRWPGKIPAGSETTQTISVMDVFPTLAAAANIKMHNKKKIDGIDVLSSMTKSKNIKRSKP
LFFASNSPEYNSFRLAMIEGDHKLVQIIDHHNRSTEITNYLFDLGEDPYEKNNLAEENPL
RVKKMSDAINDWRSQHPVSGLYVSISPNPAWRAPADYAEDVKPDDKTLLQPWAGFGRVAS
QVLQMRYGEKGRIKYE
>A0A482ZFQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MPEVGCDLRIDLSRLHYTDTAKREIRSCDLRIDLSRLHLDQTLSDLVARCDLRIDLSRLH
>A0A379ZJ35|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia marcescens|TrEMBL
MAPKYGCGLGECGACTVLIDASPLAPAQCRWPRVGSKSVTTLEGLGTAETPHPVQQGFID
EQAAQCGYCANGMIMTLVALFEREPDADEQTIKKELAYNLCRCGTHLEILRAAERARDLL
AARRQA
>A0A482ZJJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MRIDLSRLHCIDYCQHLFVCCDLRIDLSRLHSLTNRGHGHGSCDLRIDLSRLHYVADEGD
YVGGCDLRIDLSRLHSWQRMKLSSLVVICG
>A0A482ZLJ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MEIARYCCDLRIDLSRLHSITFTGDNALGCDLRIDLSRLHLHARVGVITQCCDLRIDLSR
LHCS
>H0TE09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MTPQLNRRAFVIGTAALGGGLALGLDIPFGGPQIVRAADGTPEVNAWVVIRPDDTVVIRI
ARSEMGQGTLTGLAQLVAEELACNWSKVTTEYPTPGQNVARKRVWGDFSTGGSRGIRTSQ
DYVRKAGATARMMLIQAAANEWKVPVAECTAANSVITHSPTGRTTTYGKVAEAAAKLAPP
ADVKLKDPKDWTLIGKGVKRLDTPDKVTGAMIYGIDIKLPGMLNAAIKDCPVTGGKLKSY
DEAKITGMKGVKKVVAVDGTAVAVIADTWWHAKTALDALPIVWDEGPNAKVSSASIAQWL
AEGLDSGPAYVGNENGDVKAALAGAVKKVEAVYNYPYQNHANMEPLNATALYTADKCEVW
CGTQNGEAAFAAVLEATGFPADKCEVHKVMLGTGFGRRGQTDYVRQAVQIAKQMPGTPIK
LLWSREEDMTHGRYHPITQCKLTGGFDADNNLTALHIRISGQSILFSLRPEALVNGKDPA
TFAGFNATGDAVIGYSVPNLLIEHSMRNPHIIPGFWRGVNVNHNAIYLECFMDELANAAG
QDPLEFRRKLMKDHPKHLAVLEAVADKIGWGTDAPQGVYRGLAQLHSYGSYVAAAAEISV
TDGNKIKVQRIVASTDPGYVVNPAQVERQIAGSFVYGLSGLFYGGCTVKDGRIEQTNFDT
YNSMRINEMPKVESILMPSGGFWGGVGEPTISVAAPAVLNAYFAATGKRIRSVPLRDQNI
SFA
>A0A5P8YZD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax sp. THAF197b|TrEMBL
MQLTVNGTPREVDVEEDMPLLWVLRDELGITGVKYGCGAGLCGACTVHLDGVAVRSCQTW
AADAEGAEVTTIEGLGTPEALHAVQEAWIAHQVAQCGYCQSGQIMQAADLLATTPAPTDA
DIDAAMNGNLCRCGTYPRIRAAIHDAARRLQEA
>A0A8B4S2T2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Comamonas testosteroni|TrEMBL
MPVKFTLNGKPASADVDSSTPILWTLRDTLGMTGTKFGCGMAMCGACTVHLNGQAIRSCI
TPISAAQGQKIDTIEAQAADKVGKAVEDAWVRNDVAQCGYCQSGQIMSATALLKSNRRPS
DADIDAAMAGNICRCGTYARIRAAIHDAAKNLSA
>A0A2H6B329|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR40|TrEMBL
MGVRLIVNGHEHDLDVPPEMPLLWVLRDVLGLTGTKYGCGIAACGACTVHVDGRAERSCV
LEVGSVAGKRVTTIEGLDPAGEHPVQRAWREMNVPQCGFCQTGQIMQAAALLAENPKPSD
EDIVQALDGNICRCGCYERIHAAVRLAATGV
>A0A0K8NZQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MKLTINGQDRPVPAEWQDDSLLVVLREALGLVGAKFGCGVGLCGACTVLVDGAPTRSCAL
PARAAAGRPVLTVEGLARDTALHPVQAAWLEESVPQCGYCQAGQIMGTVALLRQTPRPTD
AQIDEALAGHLCRCGTQQRIRRAVRRAAGMAP
>A0A386URY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paracoccus yeei|TrEMBL
MTRLRVNGRDHDLEVDPETPLLWVLRDELRLTGTKFGCGIAQCGACTVMLDGMPRRSCVT
PIGMIEGSEVTTIEGMEGPEVDAVQAAWTAIDVPQCGWCQSGQVMSATALLQQIPQPSDE
DINNAMAGNICRCATYVRIRQAIHDAARTLEG
>A0A7Y9W050|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MQTLMINGQSRQVDVPADMPLLWVLRDVLGMTGTKYGCGIAQCGVCTVHLDGQPVRSCVM
PVGSVASRQITTIEAIDQNAVGQAVQQAWLEHEVVQCGYCQSGQIMAATALLQNNPNPDD
QAIDMAMAGNLCRCATYTRIRSAIKSVAGR
>A0A7Z0AWH9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MSLIDGTLHEPSRRVFLKQAVTVASGLAIALYLPSGAAATEPKNTATEFEPNAWVRVLPD
GTVKLVVHKHDSGTGTQTALAACVAEELDVNPMTVQVITPEDPFFETYIHPVWKVFSTGG
STSVSLEYDRLRMAGATARALLISAAAQQWKVSPESCSTEEGRVVHASSKRSLGYGELAG
AAAHLPAPANVTLKDPAQFKYIGKLRHKRDAAAKVCGRFKYSIDVQLPGMLVAVIQRAPV
VGAKVVTVDSAAALQVPGVRKVIAIPGRPDVLGGNLEGVAVLAETFWAAQQGRQLLEIKW
SDSPLAGFDSAELSKAQIAAISDPATQTVKAMAQGDVAGQWPGAAKRLEADYTMPYKVQN
PLEPICITAQVKDKAITYWGGVQVPSSALEAAQTVCGIGKDKVTIHELVSGGSFGAREAK
YWLFEVAYLAQKTGVPVKLLNSREDEMHALFNHPATLHRAKGALDAQGKLTALQLHAVSP
ASPEQWEPGYFERPDHMDYSTTEAITAWDFAYRPPHLELNWVKHESNVPSGWYRSVSFIP
NVFAVESFMDELAHAAGKDPLAFRLANMQERPRHVAVLKQAAERAGWGQKLPPDTALGIA
TNQGYTSFIAVVARVARVDGKARVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHALFD
RLDIQQGRVVQSNFHDYRVTRMSDMPPVDILVLDGQPDKPGGVGELGSPSVVPAIANALF
SLTGVRQRSTPLNLG
>A0A5E7ZQ61|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. EC-HK134|TrEMBL
MGRARTIARRSFLIGSAAILGGVAFGAYFVSRPIANPLLDGLAQGEAALTPFVKITPQGI
TLIVPRADVGQGIASTQAMLIAEELDIDPATATLDPGQPHQAYFNGVIVGESMPFPAWEH
GAVANTMRDVMRNVERLTGSQFTGGSSSVADLHETLRLAGATARETLKAAASARTGVQRA
DLRTKAGQVVLPDGTRIPYTALAGEAAAIAPVTDVTLRPASDWTRLGKPYQRLDIVAKST
GTQDYGIDVVLPGMLHATVRANPGRGGAMAGYNADAALATQGVRAVVAVNEGLAVIADNT
WFAFQAAQALEVDWLPPDHPASSAEMWQALSAARTDAFRNSRLRDDGDVEAALAGATVIE
AEYRTPFLAHAALEPLSATVLVEAQSVQIWTATQIPGVVRDAAVALTGLDPSQVTLHALP
AGGSFGRRLDHDYVVQAIQIAATMPGTPIKTTWSREEDMTHDYPRPLHMAVGRGAVGNGR
VLAYDLDSVSPSLISSWFGRISSVPPGPDTMLVWGAFDQPYAIPNYRVTGYAAPQMIPVG
SWRSPGACSNTFFHESFLSELIHAAGADPLEERLRLIADPDSRRVLEAVGEMANWAGADI
GPGRGRGIAFAHTHGVPVAEVLDVTLTERGIRIDEVWIAADCGTVFDPANAEAQLTGAAI
FGLGHAMNCELTYENHAVQQTNFDAFEGMRLHQTPRFHTQLLGRAERVRGLGEPATAPAA
PVLADAIFAATGRRLREMPFSKFIRFA
>A0A381A4A5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella pertussis|TrEMBL
MPTLNINGKDTVLDAPGEMPLLWALRDVADLTGTKYGCGMALCGACTVHADGQPIRACIT
PVQAVAGRRIVTIEGVAADRTGQAVQQAWRELDVAQCGYCQSGQIMSAAALLRANPAPTD
RDIDDAMNGNICRCATYVRIRAAIHAAAAALA
>A0A7X6FMM9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MQSIGLLDATSPLLASRREFLFASAALLLGFAFPKTASAMVDEKGLPAAGATDAAASGFD
GFVPDGFIRIGGDGRIVLVVPSSEMGQGIATTEAMLLAEELEVGMDQIEVALAPADLGAY
GQSILKNQITGGSTSVRAFFDPLRKAGAAARTMLVNAAAQQWQVAASDCRASRATVLHQS
SGRSASYASLVELARAQPVPTEVVLKKPSEFKLIGKPLRRVDTPEKVNGTAKFGIDVAVA
GMRYAAIKICPTIGGKVKSINDRETRALPGVLDILEIEDAVAVVGEHYWAAKKGLDVLEV
EWDPGPHATLSSADLWHELRTCKATPIVAKVQGNPDEELASGIRIEATYELPFLAHAALE
PINTTIHARADACDVWVSTQVPVDAQTVTAEILGLRAEQVNIHSYLIGGGFGRRLAVDTI
QQAARFAKLADYPLKIIWTREQDIQHDRFRPAYCDRVVATLDEKTRFPKAFHHRTTGSTV
LQYFTRKGWPEGQLDPDLVAGSVNQPYRIPAAKWEWLRQDSPVAVNWWRGVGEGHNVFVV
EGFIDELAAAAAFDPVAYRRALLSDNPRARAVLDKVARASNWGEPLPQGHGRGVSLHQCF
GSYMGLVVQVEVDEYGEVYLRRATAAVDCGVPINPDSIAAQMQGGVLFGLSAALFNGVTF
KDGKVEQSNFHDYRQIRLNEVPAFEVFVMPSIEAPGGIGEVGTAAAAPALTNAIFAATGV
RLRSTPIDKSSLARKGNRDRVPETIALTSLDRAGRP
>A0A0S4V3G8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MTADATAPRRGRRRFLLGALGIGGALVVGWGVLSPRSRLGDAADFPAQPGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLTAEELDIPLARVRVERAPIERIYGNVVSVVDSAL
PLHPDDAGKAWARALHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
HAWKVPAAQVSVHDGRLIGPGGRQAGFGEVAAHARDIAPPASVTLKPASQYRLVGQPAPR
SDAAGKTDGSARFAIDVRPPGLLYAAVAMCPVFGGRLKAFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLEPVWDSGPHAALDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVGGATVVEAEYSVPYLAHAAMEPINCTAQVTRDHVQLWAPTQVATLAQLV
AARAAGVRSEQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIERGRVTALASRSAGQSILAGELGRLFGAPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEVAAAAGLDPLAMRRDLLEAHP
RERTVLDTAARAAGWGQPLAPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPGIVARQVESAVIFGLGAALHGQIQVKDGQVVQSNYSDYPVLGMADTPV
IETHLVPSAAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A7W6HG76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantimonas endophytica|TrEMBL
MVRMMLNGVEQEFDGDGETPLLWYLRDELGLTGTKYGCGIGACGACTVHVDGNPTFACLT
TVSMLEGSQVTTIEGLSKNGDHPVQVAWRDLNVAQCGYCQAGQIMQAASLVDQSDTVTDE
DIDTAMNGNLCRCGTYPRIRAAIKQAAEAS
>A0A2C9DE72|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hartmannibacter diazotrophicus|TrEMBL
MTEIPRGLSIETHLPTGEPVNLSRRRFMLASAGVTAGALVIGFGVPVRSAHAQDAATVIP
GTRVPAFLEIRPDNTARLMSPFVEGGQGIFTAMAQIVGEELDLDPSSFMVENAPAGHDYQ
IILNGMRITGGSMSTRLGYDTMRLIGASARLMILQASATRLGVPVSELTTEPGQVIHASS
GRSISFGDVAADALDLPVPAADQVTLKDRSQFRWIGKPLARLDVYDKSVGKAIYAIDCKV
DGMLHAAVQHAPRLGMSIGAIRNEAAVTAMAGVHSVHQLPGAVAVVAERWWNAKRAAEAL
QVDWEEANGTSAVEGGRIMPADFSTAAFADRLAREPGDGKEAESEGDAAGVLASAKNIVS
STYHSQYLNHAQLEPPSALARFNEDGSLDVWMPNQAPEMFQADIAKISGLETSQINVHSP
LLGGFFGRHFLYVSANPYRQAIQLARETGRPIKLIWSREEEFLRDPLRPMAAVRFKGALD
DSGMPLALEAVSVCEGPTEGINGHNPEKMDESAIEGLTGKAYAVANKRIAQLYVENPTML
AYWRSVGNSMNDFFYECFLDELADAGGKDPYELRLQLLKDNSRLTNLLKAAADMSGGWKR
GPFTAEDGSRRARGLAMASPFGSHTAAIAEVSIRAGKVVVHDVWEVIDPGSIVNPAIIDA
QINSATALGLSQVLLEEVVYEKGQPLARNYDLYPILAPDQMPRVHTRIIESGEKMGGIGE
PGLPAVPPAVVNAVSTLTGQRVRSMPLSQFTFES
>A0A840YKU8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas xinjiangensis|TrEMBL
MAEFELNGKAVSVEVDAGTPLLWVLRDDLGLTGTKYGCGIAQCGACTVHMNGEATRSCLL
PIEDVHGARVTTIEGLGQGGLHPVQELWLKHQVPQCGYCQSGMIMAAAALLSENPNPSDE
DIMARMTNICRCGTYSRVRAALEEARGGNRMGAPA
>A0A7W6GDC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hansschlegelia beijingensis|TrEMBL
MTVARNPGVSVEAARSALNPDVSRRAALGGALALIISASLPSGVLAKEDEPLKFGRDAMP
NGWRDDPRVFVAIDPEGIVTVTCHRSEMGQGVRTSIAMVVAEELGADWSKVRVAQAWGDE
TVFGNQDTDGSRSLRHFFMPLRRAGAAARTMLEQAAAAEWGVPASEVVAGDQMVRHEPSG
RKENWGRFAERASKLPLPDPASLKLRAPADFRYIGKGEIGLIDNHDFTTGKANYGIDVRL
DGLLYAVIARPPVFRGRVRKFDASAAMKVPGVLKVFEIEPSPPPTEFNPLGGVAVVARNT
WAAIKGREALKIEWDDGPNASYDSAAFRTALEESARKPGKTVRADGDVDAAFAAAKQRVT
AEYYVPHLAQAPMEPPVATARATDTSCEVWTCTQAPQATRANLAKRLGLKLDDVRVNVTL
LGGGFGRKSKPDYVVEAALCSRAMDGAPVKLTWTREDDISHSYYHTVSVERIEAALDERG
FPTAWLHRSVAPTIGSTYVEGAKNELPFELGMGLVNLPFAIPNIRIENPEAPAHVRIGWF
RSVSNIPHAFAIQSFAAELAHAAGRDPKEYLLELIGPDRILDAAALGDVWNYGEDPAVYR
LDTGRLKRTIEAAAAGVGWGRKLGEGRGLGIAGHYSFVTYTAVAAEVEVKDGEIAVRQVD
IAVDCGPQVNPERIRSQMEGAVIMGMGLGLSAEITFKDGRSEQRNFDGYDLTRIDASPKI
LNVHLLPSGDYDGPLGGVGEPGVPPVAPAIANAVFAATGKRIRGLPLNKHFGA
>A0A6J4RMF5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Solirubrobacteraceae bacterium|TrEMBL
MELHVNGTTHDVLSPPLTTLLDVLREELRITSPKAGCLQGGCGACTVLVDGEPRRSCLTP
LAAVEGAHVSTVEGLGTPDSLSPVQAAFHEHYAAQCGFCTSGFVMATHALVERGGDPSRE
EVVEALSGHLCRCTGYVKIIAAATAAVRGDVDTDAAEADMGPHDPGEVQLIPGSPA
>A0A4P6W9E0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter sp. JH2|TrEMBL
MTMNRRDFMKVSTAASGSLMLAVSLPGCSTIKTGFEKESGQWSPDVWLELTTNDEIFFTL
ARVEMGQGTYTGLTTLVAEELDVDPARIKVKFAPVAPEYRNPLYGLQATGGSTSVAISWK
PLREAGASARQMLVMAAARVWKVDDAECSTQDGRVVHPNGIDSLRYGQLVELADKEIVRG
DVALKPRSEWKYIGREGGKLDSEAKATGKAVYGIDVELPGMVYAVMTRCPRYGGKATGFN
RSDVLAWPGVLDAFITERGVAVVADRYWRARKAQNALKVEWDFSEAIDLNNDQVFDSYRE
AANEDAGAQERSDGDFDDAVESASRVVEAEYEQPYLDHAAMEPMNATAWYRDGSMEVWAS
TQAPDLARIAAARHSSLSPGDVTVHTTFLGGGFGRRLTQDYVEEVAIVAYKIKKPVKLIW
SREEDVRHGFWRPAMLHRMKASFRGNELTGWDHQIVGPQILDWYVRNAAPAQYPWAPKFL
YGTLGRVGLMAEGIATPKDMSAIEGAIGYPYQVENVSVRHTHTDPGVPITWWRSVGYSHN
GFAVETFMDELAHEAGQEPLQFRRKLLANEPRHRAVLDRAAERAGWGTPLGEGRARGISL
FKSFGTYVAQVVEASIENGEIKVHKVTCSVDCGQVVNPRVVEDQISGGILFGLSAALFGE
ITFKNGEVQQSNFHDSRVLRMHQVPEVVVDIVDSDVEPTGVGEPGVPAVIPALGNALFAL
TGKRQRRLPLTAG
>A0A839F022|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dokdonella fugitiva|TrEMBL
MQLPIPLAPAEPATPVPLATGLSRRAFVKSAAAGLVVAFIVPVAARRAVAAEPAPAAKPP
VSPNAFIRIAPDDSVTILLKHSEMGQGVWTSLPMVVAEELGCDWNRVRVEHAPAAPEYAH
TAFGMQMTGGSTSTWESFDQLRTAGAMARELLVAAAAAKLGVKAAECRVDNGHVVHGERR
VRYGEVADAAAKLPMPASVKLKEPKDWTLIGKPTRRLDSRAKTTGTAEFGLDVKRPDMAV
ALVARAPVFGATLKKVDATKAKAIAGVLDVVEVPSGVAVLGKHFWAAKQGRDALVLEWDE
GAFAQVSTANLRDEYRKLAATPGATAKAAGDVEAALKGAPSAIEAEYEVPFLAHAPMEPL
NCTVSIDGEGCEIWTGTQFQTVDQMNVGKALGIKPEQVRIHTTFLGGGFGRRASPTSDFI
VEAALVAKAAKRTVKVVWTREDDIHGGYYRPMWLSRLRASLDADGKPAAWAHTIVGQSIL
AGTPFEPMMVKDGVDATSVEGAADSPYLAAIPAHRVELHSPKSPVTVLWWRSVGHSHTAF
VVESFVDELAHAAKQDPLEYRRALLPKGARERRALDLAAEKFGWGKPLPKGHAAGLAVHQ
SFDSYVAQVAEVSVEDGKVRVHRVVCAIDCGPVVNPLTVEAQMQSGIAYGLSAALHGELT
LKNGRVEQNNFNDYVALRLPEMPKVEVHIVPSTDKMGGCGEPGTPPIAPAVGNALFALTG
KRLRSLPFRGA
>A0A841HGA5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MITLDINGKQVQTDAEPDTPLLWVLRDHLGMTGSKYGCGKALCGACTVHVNGAATRSCVL
PVSAASGMKITTIEAVGDSAIGKAVQDAWVAENVPQCGYCQSGQVMSATALLTTNQKPSD
ADIDAAMSGNICRCATYVRIRTAIKRAAESLA
>A0A841HPC7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MTELMLTRRDCLRYGLVGGALLVSFGSHPFAASEGPRPGRDATLGAWIRIGHDDSVTLLT
NATEMGQGANTGLAQLLAEELGVEWRDVRIAPAPIEPEYYSMWNEYQTGGSGSVRGMFDK
LREAGALARTLLIAAAATRWKVDPAQCRIEGHSVVDATTTRRAGFGSLAADAVAQPAPAK
VPLTPREQWRLIGKTLPRFDLPGKIDGSAQYGIDVNVPDMLIAAIAQAPQFGATLQSVDE
RSAARMPGVVRIVRLPNAVAVVAEDTWSAQRGLQALEPLWTTGKVPNNEQTQAALTSALS
EPGTVEVPRDQQEATIRSTHAAAMSSSARRISATYEVPLLAHACMEPMNATAHVAGGKAT
LWVPTQFQTKTRREVAAALGLTESDITVNTTQLGGGLGRRLEVDYAVQAALIAREIRRPV
KLVWSRAEDLQHDFYRQSAMARFEAGLDESGRATALRVRLSGIRESDGWGISRSVYAIPN
VLLTNASVPTVLPLGAWRAVVANQNTFFLESFVDEIAHASGTNPLQLRRSLLTDEPRSLR
VLNAAVAAAGVENAGASVHFGMAMVRGFGSICAQIVQVSVRARAVRVERVTCAIDCGTAV
NPDAVRAQAEGGIALGLSATAYESISVRDGRVVQSNFHDYPLLRFPQMPEVNVVIVDSPQ
ERVGGAGEPPVPPLAPALTNAIFAATGERIRRLPLSASGWTLA
>A0A7W5MYD1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. BK369|TrEMBL
MASLTINAQPLDIRLPDDTPLLWALRDAANLTGTKYGCGTGECGACTVMVDGQAMPSCTL
SLGEAEGRSVTTIEGLSPDRNHPVQQAFAAEQAIQCGFCTPGLVMAAAALLAHNADPAEA
DITAALPYVCRCGVQPRLVRAVQRAGRILRGQEPPIRLPAPRTATTGGY
>A0A1L7I3U4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gramella flava JLT2011|TrEMBL
MAEFSLEINGKSHTVEVDPDTPLLWVLRDHLKLVGTKYGCGIAQCGACTVHYNGSAVRSC
QLPVSSVAESEITTIEGLSENGDHPVQKAWLEIDVPQCGYCQAGQIMSAAALLERNPNPS
DTDIETAMNGNICRCGTYTRIKAAIKTAARSQTA
>A0A1X6Z3U5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudooceanicola marinus|TrEMBL
MSKATRLTRRAVIVGSLAVTGGLAVGIYALNRDWPNPLEEDLPEGAVSFNPWILISEAGI
TLMAPHTDLGQGIRHLQAALIAEELDVDLDQPEVTVAPGPAAPAYANRALAAEGLPFMSQ
DQGTVATIARGASARLMGALGLQGTGGSSSTPDSYVKLREAGAMAREMLKAAAAYRENLA
MADLRTERGAVILPDGRALPYAELAQTAARELPPREIPLRDPTQWRLLGRPMQRLDILAK
STGTLDYGIDLTQDGMVHATVKLNPRPGGDLLSHDDSAALAVPGVSRVLPVSNGLAVVAD
STWTAFNGAEALVCDWGPAPFLPEQADHWAALATALEGPPEKVWRDIGAQPDRPGVSPRE
YRAPYLAHAPLEPLSALIHVTEARCDIWVSSQFPGLAEQKVAAITGLPREAVHLHNQYSG
GSFGHRLEFENIIRAAEIGTALRGTPVKLTYTREEDMAHDFPRQIAMARASGQVADGQVT
ALDLAIAAPSVTASQMGRIGFASAGADSQTVAGAWSMPYALPALRVAGHAVADLAPVSSW
RSVGASTAGFFAESALDELIHEAGADPLAERLRLCDYAPARACLEAVGDMSDWGSPLPEG
AGRGVAMVLSFGTPVAEVVEVHQTDAGLRIAKVWVAADVGRVLDPVNFENLVQGGVIWGL
GHAVNCEVTYADGIAEPTNYYAHAGLRMPQAPEIFVRGLETGAEVRGIGEPPVPPAAPAL
ANAIFAATGQRLREMPFANFIDFA
>A0A6M4H7W4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter palustris|TrEMBL
MAVRKITLTVNGKPREFEGDPEQPLLWYLRDGLYLTGTKYACGAGSCGACTVHIEGEAVR
SCTLAMKLIAGQSVVTIEGLATGTRLHPVQQAWIEEDVAQCGYCQTGQIMAAVALLRRVA
KPTDADIASFMNLCRCGTYPRARRAIFKAAKRMGIAA
>A0A1V0RJ22|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus|TrEMBL
MGRAKTIARRTFLIGSAAIAGGVAFGVWRYKTPYANPLLTDLPEGATALTPYVLITSDAI
TLTTPRADKGQGAVSLQAALIAEELDVDLDQIKTDPGPPSPAYYNTALSGDAVPFRATDD
SWLAETVRGLADAPMKFLGMQITGGSTTVPDSYDKLRHAGAVARETLKATAARLHNISVT
DLRTDRGAVILPDGTGLSYQSLAAEAANTDPVTDVTLRAPSEWRLIGQPMQRIDIVAKST
GTQSYGIDVTLPDMAHAALRLNPAMGGARLSHDATPALAMRGVIKVVALPEGVAVIADNT
WRAMQAVAAIPVEWGPAPIPPEMDAHWQALSDSFTPDRQDSQFRDAGDVETALSEGSDFE
VEYRAPYLAHAPLEPLNATVLYTPDRVDIWTGTQVPRFVQNNVAKLTNLTPDAIHVHALM
IGGSFGHRLEDEVTRHATRIAMELPGRPVKLTYSREEDMTHDFPRQIAMARGRGRVANGQ
VAAYDLGIAMPSVLASQMGRQGIPAPGPDLQIVAGAWDQPFDIPHYRVTGYRAPELAPIS
SWRSVGASSNGFFHDSLLDELIHAAGADPLAERLRLCNHAPSRQVLEAVGEMSNWGSPLS
ENQGRGVAFCLSFGVPCAQVVEVTNTENGLRLDHVFVAADVGRILDPINFEGLVKGGVLF
GLGHAMHGQITYAGGAAQQMNFDTFQSLRINQCPEITVRGLENGPKIKGIGEPPVPPAAP
ALANAIFAATGQRLREMPFDKFVKFL
>A0A1W7M3M5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MSIVKDREAAGAALSRRSLNRRSFLAASLAGGAVLTFDARIALAQATGAAGEPVLLTAFI
RINADNSVTIGAKNPEIGQGVKTMLPMLIAEELDVAWNQVRIEQTDADDKRYGLQVAGGS
TATPNNWLPMRQAGAAARAMLVAAAAKQWGVAPASLSTEAGKVIDKAGGRSMPYAALARE
AAGMPVPDLATVPLKPADAFHIIGQPMQGVDTPKIVKGTPLFGIDTHLPGMLHAALVKCP
AFGGTIARIDDAAVRGIPGVVAVVPVNSGLVPPGQQDAVAIVADSWWKASKAREKLVVAW
DDAAQKQFSTAGYAKQAADALGAAPQADLFKAGDADKALAGATKTVTADYSYPFLAHATL
EPQNCTALWTADGKLELWAPTQNPGAGRKEVAAMLGIAPEAMTIHMTRIGGGFGRRLMSD
YMVLAAQVAKGVPGRPVKLLWDRTDDLRHDYYRPAGWHRFTAGLDAKGALIAFKDHFITF
GADGKPIRAAEMSSTEFPAPVVPDAHLGATYLKTNLPTGWLRAPTSNAMAFVYQGFLDEV
AEAAGIDLPELMRRTLGEPRELPTERKGLVFHTGRARSVIDAVCKAANWTGRTGPAKGAG
DAVKGRGFGFYFSHRGYFAEVVDVTVSGGTSVKVDKIWMAGDIGSQVINPLNAEHQSQGA
AIDGIAQALVWQPVVQEAGAVTADNFGDFPLLRIDAVPRDVAITWVKSDFPPTGLGEPAL
PPVIPAIANAIRAATGKRLRSLPLQLT
>A0A1W7M8I7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MAISLTVNRKKRVVDADADKPLLWVLREDLNLPGTKFGCGAGLCGACTVLLDGNAVRSCQ
TPIADAAGKQITTIEDVASLPVGKKVVDAWVDLDVPQCGYCQAGQIMSATALLTQTPRPT
AEDIEGGMSGNICRCATYLRIQKAIRKAAGVAA
>A0A7W8VYM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. Cpub6|TrEMBL
MLTRRTFLLGGASALGGLLVGWAVVPPRQRLMTSTPLPTQGTQVALNGWVKIDADNRVTI
MVPKAEMGQGIHTGLAMLLAEELDADWPQVKVEEAPIDRIYNAVQSIVDDLPFRPDDDSY
IRRGTVWITSKAVREIGTMMTGGSSSMNDLWTPMREAGASARVMLIEAAAERWDVPVREC
RAEKGYVLHPWGHKATFGELSLMAARQPLPRSVVLKQPADFRLIGQPVRRIEAASKIDGA
ARFGIDVLPDGLVYASVVMCPTLGGTVAHFDATPAQKIRGFIKAFAVPPYAGGTGGVAVI
ADNAFRAMSAVEAINVTWHDGAAAKVSSAAVDCRLVEALDHTDGHVYYHVGNVDNAMSRA
ARTIEAVYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQMPRLARHHAAKVLGLDVDLVD
VQTQLLGGAFGRRLELDFVAQAAAIAREAEGRPVQTIWSRAQDFTHDFYRPACAAWLQAG
FDEHGKLVAWHAKSAGQAIVPDALARYYGVPHIPIDKTTCEGAFDQPYEWPAARVSHKIV
ELPVPIGFWRSVGHSHQAFFTESFTDEAAAAAGQDPIAFRAMLLAQHPRHLAVLKRVEKL
SDWGRPLKPAADGARCARGVALHEAFGSVVAQVAEVSIGANRQIRVHRVVCVIDCGLPVN
PNLIRQQMEGGIVFGLSSALQNEITIVNGQVQQKNFVDFPVVRMNGCPAIEVDIMPSQLH
PQGVGEPGVPPIAPAVGNAVFALTGQRLRTLPLRLA
>A0A2M9GZV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter ruhlandii|TrEMBL
MTTTMQASRRGFLKGGLGALTLAVTGNGLVSAVWAADAPRKYGADSMPGGTVDDPLAFVS
IAADGAVTIIAHRAEMGTGVRTSLPMVVADEMEAAWDRVRVVQADADEARYGNQNVDGSR
SMRHFLMPMRRVGAAARQMLEAAAAARWAVPVAEVRATQHQVVHVPTDRKLGYGELAADA
AKLPVPKGDALKLKTRAEFRYIGKEQVRLVDLEAIGKGQAIYGMDMRLPGMVYAVVARPP
VVGGKPRRVDSAKALAVPGVLKVVDIPAMAGAPAFQPLGGVAVVASNTWAAMQGRAALQI
EWDDGPNADYDSAAYRETLTAASRKPGKVVRDQGDAPQAWAKAGEAGRFSAEYHVPHLAH
ASMETPVATVRIQDGGAEVWTSVQNPAAAQEAVANRLKLKPENVKVHVLLLGGGFGRKSK
PDYVDEAAIVAQAMPAGTPVKLVWTREDDIHHDYLHTVSAEHLEAVVGQDGKLQSWLHRS
AAPTIASLFTEGAKGEQLFESAMSAINMPYVIPNVRVETAEVAARARIGWFRSVANIPHA
FAAQCFIAELAHRAGQDHKQYALDLIGPARRIDPGTLADTWNYSESPERYPYDTGRLRGV
IEAAASGARWGREMPKGHGLGLAFCYSFMSYTATVVEVAVDEKGEVRVLAVDMAMDCGPQ
INPERIRAQMEGGAIMGLSLALLGEITFEKGRVRQNNFYDYEVLRHNASPRVIRTHLVND
DHALPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRGVA
>A0A0H3KWI0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCV
MPAVAVQGRKVTTIEGLSPDGRHPLQLAWVAEDVPQCGYCQPGQVMQAAALLNGGRPVDD
AAIVSAMSGNVCRCGTYAGIHRAIKRAASGDPALDAVAGDAKEA
>A0A0H3KED8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MSVDATNVRRGRRRFLLGALGVGGALVVGWGVMPPRSRLGDPDAFPAASGQIALNGWIKI
TPEGNVILAMPRVEMGQGIHTALSMLAAEELDIPLERVSIESSPIERLYGNVVAMGDSAL
PLHPDDANKVWARALHWIMAKSAREIGLVVTGGSSSMADGWQPVREAAATARAALVEAAA
REWGVQPTQVTVREGQLIGPGGKQMPFSAVARKAREIAPPSNVTFKPPAQYRLIGKPAPR
NDIAGKTDGSARFAIDARPPGMVYAAVVMCPVFGGKLKTFQSKAALAMPGVRHVVPFDGS
TGCAPGVAVVADHYWQARQALAALEPVWDNGPHAALDSAGIREQLVTALNSDKGGFTYRS
TGDGLKAFENAQGATLVEAEYSVPYLAHAAMEPINCTAQVTKDGVQLWAPTQVATLAQLV
AARAAGVRRDQVHIDIPLIGGGFGRRLESDFVAQAVTIAVHTEGRPVQVIWSREDDIRHD
FYRPQAIARLKARVENGRVTAIASRSVGQSILAGELERLFGMPSPGIDRYTAEGLFDLTY
EIEHEHIAHRVVELPVPIGFWRSVGHSYTAFFLEGFLNDVAAAARLDPLAMRRDLLKAHP
RELKVLDIVAQAADWSRPLAPAADGAPRARGLALHSSFGSVVAQVAEVSLEAGKPRVHRV
VCAVDCGMVVNPGIVTQQIESAIIFGLSAALYNQIQIKDGRVVQANFPDYPVLKMAETPV
IETHLVPSVAEPSGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMV
>A0A0H3KEA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MITLTLNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRSCIT
PVAAAAGKHVTTIEGLSADATHPLQQAWQELNVAQCGYCQAGQIMQAASLLKTNPHPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAVSRGGAA
>A0A3G6ZWL2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. CMR5c|TrEMBL
MITLKLNGQDHPLDVSEDMPLLWAIRDVIGYNGTKFGCGMGLCGACTIHIDGDPARSCIT
PVGSVLGKNVSTIDNLHNDPVGQLVQQAWLDTAVAQCGYCQGGQIMSATALLKIHPNPSD
EQIEEAMLGNICRCGTYNRIKTAIRRASGQLQEAKA
>A0A6S7B9F4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ultramafica|TrEMBL
MELIVNGVHHNVDADANMPLLWAVRDLLGLHGTKFGCGVGACGACTVHLDGVAVRSCVTA
LADVQGKPVTTIEGLGQGGEHPVQRAWKAANVPQCGYCQPGQIMQAASLLKQTPKPSDEQ
IVEAMSGNVCRCGTYQRIKAAIKAAASEA
>A0A0M7MMI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter sp|TrEMBL
MEHSATLAADPIGLKVNGAAVRVAAPPTTSLLLVLRNDLALNGPKYGCGLGECGACTVLI
DGVAARSCVIPVKAAQGREVTTLEGLGTRERPGPTQRAFIDCQAAQCGYCLNGMIMTVEA
LLRRDPAPSEQALRSELHHNLCRCGTHVEIMQAALRAVELRADAMARPRGPEGADA
>A0A6S6YME8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter pestifer|TrEMBL
MTLTAQLSRRGFLQGSLGALTLAITSKGFITTVWAAEAAAQKYGADSMPGGTVDDPLIFV
SIAPDGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWDRVKVIQAQADEVRYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPLAEVKAVQHEVLHPPSGRRLAYGELAAD
AARQPVPTGDALKLKDRSEFRYIGKDQVRLVDLEAIGKGQASYGMDMRLPGMVYAVVARP
PVVGGKLRRFDSTRALAVPGVLKVVEIPPMQGAPAFQPLGGVAVVARNTWAARQGRDALE
IEWDDGPNGGYDSAAYHQALESAARESGKAIRNQGDVAQVWAKAPETERLAAEYYVPHLA
HASMEPPVATVQIKGGNAEVWTSIQNPIAARDAVAARLKLDPAKVKVNVLLLGGGFGRKS
KPDFVDEAAIVAHAMPEGTPVKLVWTREDDIHHDYLHTVSVERLEAVLDKNGQVQSWLHR
SAAPTIASLFSEGAKGQQMFESAMSAINMPYRIPNVRVETAEVEAHARIGWFRSVANIPH
AFAAQCFIAELAERAGKDPKDFALDLIGPARQIDPGTLADTWNYSESPERYPYDTGRLRG
VIEAACKGAEWGRTLPKGHGLGLAFCYSFMSYTATVVEVAVDEKGEVRIVAVDMAMDCGP
QINPERIRAQMEGGAIMGLSLALTSEITFEKGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHALPPGGVGEPPVPPVAPALCNAIFAATGKRIRNLPVRRVA
>A0A840AI01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseococcus suduntuyensis|TrEMBL
MSTGTTLTRRGVLAGGLAFTFTFTAGEGAAAQPGTGPLNAYVAIAPDGTITIQAPVPEMG
QGTNTALPLIVAEELDADWEKVRIETAPVRAAYDSPIFRSQFVVASLSVRGYWMPLRMAG
AQARRVLLDAVAARWGVPVEQLSTEPSTVVHAASGRRMSYGEVAGFARAPATLPEITPAA
LKPVSAFRLIGRDVARFDVPAKARGQTLFAMDVRLPGMLHATVARSPGLGARPVSHNGAA
LLGRPGITHVLPLDQGVAIVGERVEAVLAARRELSVQWSPGEGAAHDSEAALTSYLEDVR
DATKPGVQVLRTSEPEQALAGAARVHSAEFTSDYVYHGQMEPLTCVASVTEGGVEIWAGT
QWPSLVRDEAARILGIPAERVTVHMLTMGGGFGRRAAIDYAVEAVHVARAVGRPVKVMAM
REDDMANAHVRPMTAHRIEVGLDAAGRITAWRHRLASDLVVPQLYGRARLEAQRGVDHIV
TYHANVAHYDVPATVTQHLYREHGVRTAPWRGIGAGPNAFAVEAVVDDLARQAGTDPLAY
RLALLRDARARAVVEAAGAMAEWSRPRAGTHLGIGFSKLGLPQLGEALAATVAEVAVDRA
AGTLRVLRLWCAADVGLAVQPRNAMRQIESSLLWGVSSALTERLTFRDGAVQQSNFTDYE
MLRAPDTPEVQVRFVGGGEVPLPVAELGLGTVAPAISNAVMAATGRRLAAIPFTQERVRA
ALAG
>A0A653UD16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. 9I|TrEMBL
MSALHSQSRRSFLRTSAVGGAFMLGMSAQGALAAAAGAAASPEFTPNAFIRIGRDGRVTL
ISKQPEIGQGIKTSLPMVIAEQLEVDWKDVRIVQGDLDTAQYGPQGAGGSTSTPTNYENF
HRLGAAARMMLVQAAANTWKVPVSECTAQSGAVVHGPSKRRLGYGALVEAAAKLPVPDAK
AVVLKDPSTYKLLGTRIGGVDNAAIVSGKPLFGIDVRLPGMLYAVYAKCPVFGGKPVSAN
LDAIKAMPGVKDAFIVEGTNNLNGLRPGVAIVATSTWAAIRARRALEVVWDEGEGAGHSW
ADFTAQAQAASKQAGAATVRKDGDVPAALGKAAKVVEGAYSYPFISHASMEPQNCTAWIK
PDGALELWAPTQNPGSGQALVTTTFGIPKEKITLHIIRSGGGFGRRLSSDFIVEATAIAQ
KVAAPVKLTWTREDDLQHDHFRPGGFHFLRGGVDAAGKAVAWHNHFVTFANRVEREGKSV
VQPGSGGNLFADEFPGRWIDNCLFEQTVLECRIPMGPWRAPGSCVFSWVLHSFIDELAHA
GGRDPLEFRLELLGNKDFMPASSERGLPYDVKRMRNVLVEVAQRAGWGKKQFPRGQGQGI
AFHFSHRGYVAQVAEVTVSRDGKLKVDRVVVAADVGSQIVNLSGAENQVQGSVVDGLSTM
MFPELNIEKGRIVQSNFHDYQLLRMPDTPTKIETHFIKTDNPVTGLGEPALPPLAPAVCN
AIFAATGKRVRQLPLSKTDLSWS
>A0A7W6UFD1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium esperanzae|TrEMBL
MTKTSLPQAVALSRRSFLVTVGGTAVTVAFASLSSVALGAATAQAATGDFTPNVWVTIAS
DGIVSIISPASEMGQGVMTSIPLLIAEDMDADWDMVRIVQAPADAEKYGNPNFGGAQLTA
GSDTTRGYYLPLRLVGAQTRKILLAIAADRLNLPVGELTTEPSRVVHLPSGRSLGYGEIA
ATGELPDVLPQVSEADLKPIDQCRYIGRMDVNRIDVPSKVNGTAKFGIDVELPDMLYGAV
LRSPVPGEAPESIDDAAARAVKGVIHVVPLRNGVGIIGESYDAARRAKEVLNVTWTNSSS
VRRYNSTRLVEAYRDVGRDLAQAGVISHELGADAADAIAGAARVIAADYLSDHVHHVTME
PMNATALVSNDSIEVWAPTQGPGTARDLAARIGGTTPDKVKVHTTLLGGGFGRRAEQDFV
IEAVMLANAVQGRPVKVIWSREDDVRHGKYRPLAAQHLQVGLDASGNIVGWHHRLVADSI
LARISKDRFQRAGGQDSLVTDGAIHNYSVPAHLVQFVRQDNGQDVGSWRAVGNGYTKFAI
ECVIDEVAAAKGVDPVAFRLELLSEQPRARKVIEAVAAMAEWDSPRDGRALGIAYSDAFE
AHCAEVAEVSLDRESGEIRVHNVWCAIDPGVAIQPLNIEAQVAGAIVHGASHALYEQLNI
VDGEVQESNLDTYRVMRMSEMPQIHVRIMPTPENRPAGIGEAGLPPVGPAIANAVARLTG
GVRLRHYPFLPERVKAALSS
>A0A653J566|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. 9U|TrEMBL
MASRRGVLVGGLAGGALVVGYMVRPRRYALPLTPGKDEVAFDAWIKLAADGVVTVAVPQV
EMGQGVTTLIPQVAAQELGADWRQIAVEPAPISPLYANVPLAAQWAELTMPATPGWLVGE
GGAWVRRWAQDHAFTVTADGTALAAYEAQVRNVAASLRALLCMAAASRWNVAWQECGTAK
GFVVHEGKRLPFGPLASLAARFDPPGTPPLRAEAPGENPDDLPAGSPQTFPRLDLPAKVD
GSLVFAGDVRLPGMVHASIRHGPIGAARLAGYDKEAAHAVRGLITLVHNPEWIAAVATNW
WAADTALSRIDAGFSATDRADSSLIDEAMDKAMQTGDATRIHSRGDPDSYLSGRLPLQLR
YEVAPALHATIETASATAHFHEGRLELWVGTQAPQAARAAAASALGIDPLLVTLYPMPLG
GSFDRRLEHDHVVEAALVAKECGRPVQLMWSRKQEHIAGRPRTPVIAVLGANVDPAGRLG
GLRARIAAPPAAKEFGRRLLHGDAPLEAIAAVRGEADAMVLAGAVPPYAIEHLAIDHVPA
EVPLPSGRMRGNAHGYTAFFTESFVDELAHRAGREPLAYRMAMLGNDPRLAECLQRVAAL
SGWGGGADNSGQGIACHVIGEGRIAVVASARRDADGVRVDKLSAVADIGRIVNVDIARQQ
IEGGLVFGLGLALGCSTAYEAGLPVTGRLGALGLPVLADCPSVEVAFVKSVAEPADPGEL
GVAAVAPAVANALFSATGLRLRQLPLLSEDV
>A0A2R8C4H6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria mediterranea M17|TrEMBL
MGIGKILRRTFLIGSAAIVGGVAFGAYRVTRAAPNPLDPSEGQAALNPFVLIDQNGVTLF
APRAEMGQGVKTSWAALIAEELDVELEQVNVLHGPAAAAYYNSAFLSDGLPGKGYDKSDF
QHNLGEALGVIGKSLSLHGTGGSTSMKDGFIRMREAGASARETIKQAAAEQLGVDRSQLK
TEAGQVIAPDGTAIPYAELAEATAGLEPVEAELRDPAEWRYLGRSQPRVDMVGKSTGTAE
FAIDVRLPGMKFATVRRNPKLGSGMKAFEDRDAKSMPGVEKIIDIGDGIAVIGTNTWLVI
QAAEAVEIEWEDATYPPTTDAIFDQIAKAFDGSPNSTMRDDGDVDTPVEGATEITADYTA
PYLAHSTMEPMTAAAQLDGNGLQVWTGTQMPLFAQMRAASVAGLESEQVEINTTYLGGGF
GRRLELDFVEVAVKVAMAVPGTPVLTTWSREEDMRHDYFRPGAMARLRGAVKDGKAVLID
GHVAAQSPVQQAMERITGIAGGGPDKILVEGFFNQPYAVPNYRMSGYVADVQVPVGFWRS
VGNSYNGFFHETFMDELAHAAGRDPLEFRLEHARNEWDVAARCLEKVRDMSGWTGKTPDG
VGRGVAMTYSFGTPVAQVIEVVDEDGTIRINKAWIACDMGLAIDPHVVKAQMFGGMMYGL
SAACFGEITFDEGEVEQWNFPDYDALRMHSAPEVEVEVLETNRFMGGAGEPGTPPSMPAL
GNALFDLTGTRARSLPLSHTFDLLI
>A0A509EK40|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MTAALSRRVFLAGSAATAGSLSLGFHLPSATAAPAATPEINAWVVVRPDETVVIRIARSE
MGQGTLTGLAQLVAEELGCDWSRVTTEYPTPGQNLARNRAWGDFSTGGSRGIRESYAAVR
QGGAAARTMLVQAAAAQWGVPPAECRVENGVISHPASGRSTSFGRVAPAAAALAPPKEVA
LKDPKDWTIAGKPLLRLDTAQKLDGSQVYGIDLTLPGMLNAAIRDCPVQGGTVKSFDAAA
VSGMPGVRKVVQVGDSGVAVVADTFWRAKTAVEALPIVWDEGPNATVSSETIAATLREGL
DAEEAFVGNKAGDVEAALKGAARIVEATYSYPFQNHATLEPMNATARWTPERCEVWTPTQ
NGEAALAAAAEASGLSARACEVYKIHLGGGFGRRGATHDWVRQAVLIARELPGTPVKLIW
TREEDMTHGRYHPVTQCRMRAGLDKDGNLTALRMRISGQSILAAIVPGRLAPDGKDPVTF
QGLNPGGPEAAIGYTIPNLLIDHAMRNPHVIPGFWRGVNTNPNAIYLESFMDEVAHAAGQ
DPLAFRRKLMAKHPKHLAVLDAVAERIGWETKPPAGVHRGLAQIMGFGSYVAAAAEVSVS
EDGTVKIHRIVAATDPGIAVNPQQIDAQIAGSFVYGLSAALYGECTVKDGRIEQTNFDSY
PVMRLDEMPAVETILMPSGGFIGGVGEPTIAVAAPAVLNAVFAATGKRVRQIPLKHTDLR
RA
>A0A7W6WCH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium mongolense|TrEMBL
MDVVTLSRRKFLIGTAAAAGGFSLGFQIPLSANAEQAASDILPEVNAWVLIHPDDTVVIR
IARSEMGQGTLTGLAQLVVEELECDWSKVTTEYPTPGESLRRERVWGSFSTGGSQGIRGS
HEYVRQGGAAAREMLIAAAASTWNVPSSECTVQNGIITHPASGRSTSYGAVAALATQMPV
PSTIALKDPRDWKIAGKPLPRLDTADKLTGGQIYGTDVQLPGMLNAAVKACPVFGGKIAS
FDAAAVAARPGVRKVVQVDEATVAVVAETWWQAQSALNALPVAWDDGPNAAVTSASIAAM
LAEGLDADEAFVGTSIGDAPAALEGAARVVTATYSFPYQAHATMEPMNATARYTPDKCEV
WVPTQNGESSLVNVAEASGLPIGQCEVYKLHLGGGFGRRGANESYVRQAVTLAKEFPGTP
VKLIWSREEDMLHGSYHPTTQCRMRAALDADGNLTALHMRISGQSILSSLRPQMFRENGH
DPIVFQGLNANGSEGVFGYTVANLLIDHAMRNPPVPPGFWRGVNLNQNAFYLESFLDELA
DAAGIDPLDFRRKLMADHPKHLAVLEAVAERIGWETPAPQGIYRGLAQIMGFASYVAAAA
EISITDGQLKIHRIVAATDPGHIVNPAQAERQVEGSFVYGLSACLYGECTINGGRVEQEN
FDSYEVMRMEQMPAVETIIMPSGGFWGGVGEPTIAVAGPAVLNAVFAATGKRIRQLPFKN
NSPS
>A0A7W6RIB8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium mongolense|TrEMBL
MTLQHISTTRRAFLAGSGLVIGFALTPRMPALAAVTGVQAGGDDALAMLNTFVKIGNDDT
VTVLSKHIEFGQGPFTGLATLVAEELDADWGQMRAVHSPADDKVYANLAFGVQGTGGSSS
IANSYQQFRKAGATARAMLVAAAADEWKVPAGEIIVEKGRIRHSGTGKESGFGAFASKAA
AIAPPAEVSLKDPEKFVLIGQELPKLDTVSKTNGAAIFTLDVIPDNLLVAVVAHPDHFGA
TVRSFDDSQARKVTGVIDVKQMAQGVAVYAEHTYAALKGRSLLKVDWDLSEAETRSSEEL
AADYANTAKENGLSAASKGDVDRAFAGEGLETLEAEVVFPFLAHAPMEPLDAVFMKAPDG
SLDVYTGAQFPGMDKTVAAKAVGLDPSKVRINTQITGGSFGRRAQFGSPYMQEAAAVFAA
TDQSRPVKHMWTREDDIRGGYYRPMYLHRMRGAIDKNGQIVAWDQTIVGQSIMGKADLDE
TSVEGAANLPYNVANLRVMSHNVKLAVPPLWWRSVGHTHTGFAVETFLDELLQKVGKDPV
EGRLALLTEDPRYAGVLRRAAEIANWGAKPAEGRQRGVALVKSFGTYVGQIVEISVASDG
APRVHKVWCAVDCGVAINPNVVKAQMEGGIGYGLGAVLFDAVTLGKGGAIVQSNFHDYRS
IRINEMPDVEVAVITSAAAPTGVGEPGVPPVGPAVANAWRRLTGNPVRSLPIVSASTS
>A0A839F986|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium sp. P30BS-XVII|TrEMBL
MIALNINGEDRNVDVPEDMPLLWVLRDVIGLTGTKFGCGIAQCGACTVQLDGRPVRSCVL
PAASVGSRKITTIEAVSATPSGKKIQDAWLNLEVVQCGYCQSGQIMSASALLDRNPDPTD
RDIDAAMSGNICRCGTYPRIRAAIKQAAKA
>A5EFF9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MANLTINGKVYDLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGAAVRSCGV
TVSEAAGKQITTIEGLGSESGLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSD
QDINDAITNICRCGTFAQVREAIHAAANA
>Q3KDG7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens (strain Pf0-1)|TrEMBL
MTQITLNVNGSTQALELEPDMPLLYALRNHLGLNGAKYGCGLGQCGACTVIVDDQPVFSC
LTPCAGLEGKKVRTVESLGTAEHPGSLQQAFIDKQAAQCGYCIAGMLMRAQSLLERNPHP
DEQTIREHMSVNLCRCGTHLRIIEAINLVARQNGSAL
>R7ZYE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lunatimonas lonarensis|TrEMBL
MIPKFPFLSFPQKSQSTSRVFQPARRDFLKLGALAGGGLMLGVTFQCSTKDGAQVFSPNA
YLSIDADGTVTIIAHRSEMGQGIRTSLPMIVADELGADWSQVKIVQAVGDEDRYGNQNTD
GSFSVRMFYEPMRRAGATARYLLTKVAAEEWGVDASECKAEKGQISHTGSGRSLGFGSLA
SKAQALELPDPAEVILRDFSEYKLVGKDTPIIDLKDFVTGKAVFGADVVLPGMKTAVISR
SPVVGATISSYQDAKALAVPGVLKVIKISGAGIPPGLNKPLEGLAVIADHTWAALEGRKA
LEIVWDMGPNAGYDSRKQLDEMKASTQNDGMVRRERGDFKSALTQASRVIDRVYEAPFYA
HATIEPPAAVARFEGGKLDIWAPTQHPQWAKESVAEATGLPLADITVHVTLLGGAFGRKS
KPDFVVEAALLAKETGLPIRVQWTRDDDLHHDFFHSHSAQRIRATIDGSRRLLGWNHHTV
FPAIGATSNADELHPSDGELGLGCIDFPFEVPNIRIETHESAAHTRIGWMRSVSNIHHAF
AICTMMDEVAEACGKDPVAFNLEMLADDKKLTFEGEIKGDFGNYGESLEEFPWETARLKG
VIRRVAEESGWGKSMPAGSALGFAVHKSFLTYVACVVELRRDSAGKITIPEVHYAVDCGI
AVNTDRVRSQFEGGAIFGASIANTSAITLKDGKVEQNNFDGYRLVRMPESPRKIHVHIIE
SSRKPTGVGEPPVPPLAPALANAYYKLTGKRVYQLPFSLS
>A0A0A0BFY4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylophaga thiooxydans|TrEMBL
MKDNIANISRRNFVKGFALSGLVLAVGLPGISAAEEAKKYGRDGMPHGWVDNPLVFVSIA
EDGTVTIVAHRSEMGQGVRTSLPMVVADEMEADWAQVKVVQAYGDEEKFGNQDTDGSRSV
RHFFMPMRNVGAAARMMLETAAAALWSVPVSEVKAMNHKVVHEATGRTVGFGELAQSASK
LPVPERESLIYKDASDFRYIGKSDMKLADGEVIATGQTEYGMDIRLENMVYAVVAHPPAY
GETLASYDDKETLKVPGVIKTLTLPSSAPPAVFNPLGGVVVVAENTWAAIQGREKLKIEW
NSGPNSDYESAAFRKKMQTSANQKGGKVLRQLGDSYQVLEDAEATISADYYIPHLAQAPM
EPPVATAYFNGDSCELWAPTQAPQASRDTVAKWLELKPEQVKVNVTLLGGGFGRKSKPDF
LVEAALTSKALGGKPVKLVWTREDDIQHSYFHTVSYEHLQAAFDENGKTQAWLHRTVAPS
ISSTFDASSVHQMPIEIGMGVVNIPFSIPNIQLENPAAENHTRIGWFRSVSNIPHAFAVQ
SFISEMAHQQNRDHKALLLELIGDDREIDPRTLRDEWNYGESPEQYPLNTGRLRRVIEHV
TETANWGKSLPEGQGQGLAAHYSFVTYVAAVVEVKVSDDGELSVPKVDISVDCGPQVNPE
RIRSQIEGACIMGISLAMLGEISFKDGVAVQNNFDGYQVSRMNEAPAEINVHLMPANSYD
DPLGGVGEPGMPPIAPALCNAIFAATKKRIRNLPIRYQLEA
>A0A3G7UPT6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MELRINQKAYQVDAEADTPLLWVIRDNLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAIEEDEVGKRVVATWVERQVAQCGYCQSGQVMAATALLKHTPAPTAE
QINAAMINLCRCGTYNAIQSAMQDLAKQESV
>A0A0A0HRB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus DSM 17069|TrEMBL
MGRVKTIARRTFLIGSAAIAGGVAFGVWRYKTPYANPLLSDLPEGAAALTPYVLITSDAI
TLITPRADKGQGAISVQAALIAEELDVDLDQIKTDPGPPSPAYYNTALAGDAVPFRATDD
SWLAQTTRSLADAPMKFLGMQITGGSTTVPDGFDKLRHAGAVARETLKATAARLHTLSAT
DLRTERGAVILPDGTRLSYQSLAAEAANTDAVTDVTLRAPSDWRLLGQPMQRIDIVAKST
GTQDYGIDVTRPDMAHAALRLNPAIGGARLSHDPTPALAMRGVIKVVALPDGVAVIADNT
WRAMRAVAAIPVEWGPAQIPPEMDTHWQTLSDSFTPDRQDSQFRDAGDVETALSDGTDLT
VEYRAPYLAHAPLEPLNATVLYTPDRVDIWTGTQVPRFVQNNVAKLTDLTPDAIHVHALM
IGGSFGHRLEDEVTRHATRIAMELPGRPVKLTYSRKEDMTHDFPRQIALARGRGRVANGQ
VAAYDLGIAMPSVLSSQMGRQSIPAPGPDLQIVAGAWDQPFDIPHYRVTGYRTPELAPIS
SWRSVGASSNGFFHDSLLDELIHAAGADPLAERLRLCNHTPSRKVLEAVGEMSNWGSPLA
PNQGRGVAFCLSFGVPCAQVVEVTNTDNGLRLDHVYVAADVGRILDPINFEGLVKGGVIF
GLGHAIHAEITYAGGAAEQSNFDTFQSLRLYQCPEITVRGLENGTRIKGIGEPPVPPAAP
ALANAIFAATGRRLREMPFDKFVTFI
>A0A0N0NGS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinobacteria bacterium OV450|TrEMBL
MTGQSRRSFLTHLVAAPTLALVTRAGADALAPQSAHAVVPTLPAPADLVDLGDLFILAGA
PTSALLALSVETDGTVRFRLPREEVGQGLTTAVAMLVAEELDVPLASVRVELDDARPELL
FNQLTGSSNSVRSLYGPVRQTAATARARLVAAAARRWNLAASSLTTADGAVRAPDGRTAD
YGGLAAAAADPALTVLGAAPKKASTHTLVGRATGRIDARAMVTGAQQYTLDLDVPGAKPC
VVRRPPTLGGSVTSVANLAAVRAMPGVLRVVTVPTGVAVVAETFGQALDARAALQVTWGP
GPADRLSDAEIRAALRAATPPLLVPPLLTPYVDAEFDFAFVSHAPMETNSAVADVREDRA
EIWSGLKSPIVARETIAADLGLPLDKVTVHVVQAGGSFGRRLFFDAALEAARVSKACGRP
VRLMWTRVDDTRHGRMRPATHHKIRATHLLGEVLSFEHRVAAAETDFRHGLGEIITATAA
GLPPGIGNATLAQTLFHTTIKSPYHFGLTTHGLSEVPTGIPTGSWRSVYSANTRGAEEIV
VDELAARTGKDPYRFRRTFLKTDAQRAVLDKAATQGEWGRPMPVGCAQGIAFHEEYKSRT
ACLVEIDARDREHVRVTKAVIAVDVGLPVNPRGLEAQMIGGLTDAISTTLKAGLHLDKGL
PLEGSYSQFHWARQRDTPRDVRVFVLPATGEEPGGAGELGVPAAVGAIANAWARATGAKP
RSFPLDFDVDFTPYPR
>A0A7W9B0B2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Brucella daejeonensis|TrEMBL
MFTFTVNGKDFSVDVPEDMPLLWVLRDHLSLVGTKYGCGVAQCGACTVHVDGAPVRSCQL
TIGDIGDRQVVTIEGIGDTPSGAAVQQAWMEADVPQCGYCQAGQIMSATALLNTTPHPDD
LDIDAAMAGNICRCGTYIRIRRAIKSAASKLA
>A0A7W9B0A2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Brucella daejeonensis|TrEMBL
MTDTQSGFAQSDAYLSALISEVRSRPAVDFSLNSGFTTGRRGFLKLAGMGVAGLVLGFHL
GDTAFAEEAQDNTENGDDRAINAFIRIAPDNRITIFSKAPEIGQGIKTSFGVIIAEELDA
DWNNVVVEQAPIKPDVYGNQGAGGSTSIPLAWNQLRQAGAGARAMLIAAAAGQWGVDASQ
IVARESVLSHAASGKSATYGEFAVAASQMPVPDPAALKLKARNEYGLIGKRHHGVDDSKV
VTGQPLFGIDVQLPGMVYANYTKCPAAGGKALSFNRDEITAQPGVLDAFILEGTGIPAEV
MPGVAIIAKDTWSAFQAKKKLRVDWDRSEASKDSTSRFSRDARKAAALFPSQADDNVGDV
DKAFAGAAKTIEAYYEYPFVAHAPLEPMNTTAHWHDGIMEMWVPTQQPVRALPLVAKVAN
IAQEKIVMHQTRVGGAFGRRLVNDYTCEAAAIARKVDAPVKLQWSREDDFSHDFFRPSGY
HQFKGAVDENGRLDAWQEHFITFTADGKKEAAASGLTENIKYSIKAPNLRRGTTMFPLRI
PTGAWRAPGDCVQVFAAQSFMHELSLAADRDHVEFLIDAVNRDVPELAPQPGANGTIANF
SPRRATDVIRMCADKADWGKTLSKGKGMGLAWCYSHAGHAAQAVELSVDAKKRIRIDRIV
VVLDVGPIIDLAGSEAQAQGASTDALSTALGLKINIENGEIEEQNYNAYPILRMPFAPMN
IDAFFIQSDNPPTGMGEPAFPALAPALGNAIFMATGERVRRLPLRDLGYSLAT
>A0A853ARY8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora hordei|TrEMBL
MGRRKFLGYLIGGTGLVAAANAGLLGSPTQASAVTAPVPADLLDLNDVLTTAAQPTSQLI
KVEVHEDGTASFELPRAEVGQGITTSIAMIIAEELDLPLEKVRVTLAPARPELLFNQLTG
GSNTIFAMYTPVRVAAALAKQALLEAAAVLLGDTVANLTTKAGEIIGSTGRVSYGELVPR
AAVPKTTPREVELKPASEFRVVGTPQNRKDALAAVTGQKQFAMDLHVEGALPAMICRPPT
IGGSPEAVLNAAEVKAMNGVTHVEVVPSGVAVRAHTFGQCIDAIRALRVKWKPGTAEGAS
DDSIRAEIKSAELPMAVPHVPPLAETMDFDFTFYFRSGSPLEPNCAVADVREDSATIWAS
AKSPIAAKQEIARVLGLPSGKVTFNVVEGGGSFGRKLFFDGALEAALVSKACGAPVRLMW
HRADEPRHGRSHPMVTARVRVAHLGDQVLSFEHRHTGVAVDFTHGLGEAITAAAGKLPIA
GNLSLAETIFETTQFMPYDFGVITQLLMETGEHDRFPTSAVRNVYSPDVRTANELVVDQL
AKKLGKDPYEFRMAYLCKERVKRVLQKVAEAGEWGKRMPAGMAQGIAIHEEYKGASACLV
EIDCRPETVNRKVRDAVTGPLVTKVTFAVDVGLAINPTGVEAQMQGGICDGIALALTNSS
HLVDGHFLEASWDNSAYTRQWNTPREMQVFVLPSDNPPGGAGEAGVASAFAATACAYARA
VGRVPQYFPINHHDPLHFEPKSFIPPVPASPTDRLEHTY
>A0A0Q0FCS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas sp. P1-25|TrEMBL
MITLTVNGNKHEFTGDPSTPVLWYLRDELNLTGPKFGCGMAQCGACTIHIDGVAQRSCIL
PVSAVVGRNITSIEGLSEQGDHPVQKAWVEHKVPQCGFCQCGQIMQAASLLAANPNPTDD
EIVNNMSGNICRCGTYPRIHKAIKSAAKTMAGVEYFDPNEQGEEV
>A0A1Y0E9R3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Yoonia vestfoldensis|TrEMBL
MAISLTINGTAHRVDLPDDVPLLWVLRDAIGLTGTKFGCGIAACGACTVHIDGQAVRSCQ
VALADVWGAVTTIEGLGQPGNLALIQQAWIDHQVAQCGYCQSGQIMNAAALLAEIPAPSD
ADIDAAMQGNLCRCGTYPRIRAAIKDAAQRLAEV
>A0A6J5KDP8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia phenoliruptrix|TrEMBL
MGSLNINGQAVAVQAEPDMPLLWVLRCELGMTGTKFGCGVGICGACTVHLNDKPFLSCQI
SMSDLNTQKITTIEGLQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKEKPHPTDA
DIDAAMSHIVCRCGTYPRVRAAIHQAAKRRPA
>A0A839U874|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MFDITVNGVKHQVDVVPEMPLLWVLRDELGITSPKYGCGIAQCGACTVQVDGAAVRSCQA
RMADIAGKAIITIEAVGNGKLHPVQEAWIEHQVPQCGYCQTGQIMQAISLLKSNPKPTDE
DINEVMSGNLCRCGTYERIRAAIHTAAEKIGGN
>A0A7W6WZV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MATTLTINGETKSFDAPPEMPLLWVLRDILGMTGTKFGCGIAQCGACTVHVDGKAVRSCV
LPVSAVANRTVTTIEHVGSTPAGAKVQKAWLEAEVIQCGYCQSGQIMAAAALLAATPNPD
DSDIDAAMAGNICRCGTYVRIREAIKHAANGRQS
>A0A378Z2Z2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea pulmonicola|TrEMBL
MRELRFSRFAPFHGVAVGDYAGVSRRAFLKTSALAAGGLMLEMSVPGAARTASAQGAAST
PVVPSAFVRIAPDDTVTIQVNRLDFGQGVQTALPMLVAEELDCDWGKVRSELAPAADVYK
DPLFGIQMTGGSGSVAHSWLQYRRIGASARAMLIAAAAQQWKVPPAQLRTENGVVLGPNG
QRATYGSLAAKAQAMPVPTDVTLKDPSKFRLLGKPTGRLDARAKSTGVPMYGMDFKLPDL
KVAVVARPPVFGAKVKNFDAKAARAIKGVRDVLEIPDDRGGTAVAVIADGYWQAKTGRDA
LKATWDTSGVEHVDTTTQLAKYKEIAKTPGTVAIDADMSALKNAPKTLVAEYSFPYLAHA
PMEPLNCTVQLTDRGVEVWTGTQFQTVDQAAIARTLDLKPEQVKLHTLMAGGGFGRRAVP
TSDYGVEAAQVAKAWKRAGHREPIKVIWSREDDIHGGYYRPMYVHRAEIGLDAKGNVLAW
NHTIVGQSILQGTPFEKMLVKNGIDSTSIEGVSGTPYAVPLRLTLHSPQVNVPVLWWRSV
GNTHTAFVMETLIDELAKNAGQDPVAYRYALMGGKHPRHRAALALAVERSGYGKTRLPEG
QAWGVAVHESFDSVVAYVVVAEMRNGSPRLVSATAGVHCNFAVNPLTVAAQVEGAALMGL
GTTLPGAAITMKDGEVEQSNFHQYTVARLTDMPAIGVHIVSSGDAPTGMGEPGLPALAPA
YANALFTLTGKRQRALPFDMTKA
>A0A839XT08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella sediminis|TrEMBL
MPHRTTRPAEGPRPDGEPGKPLGRRRFLGYLMAAPTLAVAVRLGVDANAPSEAGAAAATP
VPSNDLPADVFDLEDTQTYAAKPTAHLIWLEVREDGTVHFALPRMEVGQGIVTTTAMLIA
EEMDISVDKVEVTLSKARPELAMNQFTGGSNTTMSTYYPIRTAAAIARGALLDAAAHMLG
GLKPNLLETEAGAVVSPDGKRIPYGDLAGAAAVDKTTRKEAELKGSSEFTVIGKPRNRTD
AVNAVTGRKQFATDLDIAGAMPCMVCKPPTINGKVRVVRNAEAVRDMPGVTHVETIKTGV
AVRARTFGQCVDAVVALDVDWEPGLVGSDSDEDVLAELKSAELPMAVPEVPALAETIDTG
FTFAFASNAPLDPDCAVADVRADSAEIWSGLKAPIVAQQQIAEALGLPLDAVTVNVVQAG
GSFGRRLFHDGAMDAALASQAMGAPVRLMWHRADACRQGRVHPMATSRVRTTLLGDKVLT
YEQRHTSARTDFGHGYGDIISAAASKLPVADYSISQWVYVLTQGAHYNFGPTTSLLQELT
DRRFNTGAMRNIYSPNVAVAREVTVDKIARKLGQDPYQFRRAHARRDRLRAVLDKVAEAG
DWGRKMPANHGQGLGVHNEYHGYSACLVEVDASPETVDRKVRQAVTGPRVTKVVFAVDVG
LVLNPKGLEAQMIGGIMDAIAIVLTSSVHLQDGNFLEASWDNYAYTRQWNTPFDVQIHIV
ESADEDPGGAGEFGVPAASAAVANAYWAATGTMPTEFPINHNGDLHFEPYPYSPPVPQSP
TDGLDYVR
>A0A839XRA7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella sediminis|TrEMBL
MPEHTFKLNGKPVTVDTEDNVRLLWVIRDLLGVTGPKYGCGINVCKACTCHINGKAFNPC
SVQVSDVGPDDEITTIEGLADTVESDLHPMQEAWLDHDVVQCGYCQPGQIMAAVATVRKA
RDEGRELTDADIEGIRNVCRCGTYFRIREAIKDGATRM
>A0A839PAW7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium sp. R2-1|TrEMBL
MLKLDSIDAPVPSRRAFLTGAAAGAVLLAFRLDLKGARAAAGSDALSKAPAQPNAFVRIA
ADDTVTVMIKHLDMGQGNTTGLATILADELDADWSQMRVAFAPADAKLYANLLMGPVQGT
GGSTAIANSWFQLRKAGAAARAMLVAAAAERWGVPAAEITVAKGVIGHKSGKQARFGEFA
EAATAKPVPQEPRLKTPAEWTLIGRRVPRIDSAAKTDGTAIYSLDIRRPGQVTALVAHPP
RFGATVKSVDAEAAQGMPGVVGVVTIPTGVAVIARDTWSAMKAREALKITWDDSAAETRS
SDAILAEYRQTAKTPGLVASQAGDADAGIKGAAKVLEAEFSFPYLAHAAMEPLNATIERA
ADGSYDVYAGCQIQTVEQAVLAATLGVTTDKVRLHTQWAGGSFGRRATPGADYFAEAAAI
VKAWDGKAPVHLVWTREDDMAGGYYRPQVYHTVKAGLDAKGQITGWRHAMVGKSIMIGSP
FEAMLVKNGIDSTTVEGASDTPYALPAYRFEVHNAREGVPVLWWRSVGHTHTAHVMEVFI
DELAHAANADPVAYRLSLLTRAPRLSGVLRLAAEKAGWNQKPSEKGRGLGVAVHESFGSY
VAMVADVTAGDSTAKVNRIVAAVDVGIAVNPDVVRAQVEGAVGFALSAVLRNRITLKDGV
VQETNFDSYQPTRISEMPRVEVHIVPSDVAPTGIGEPGVPVLAPAIANAVFAATGQRLRS
LPLDLSALRGA
>A0A5P9PPZ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. YIM 10|TrEMBL
MPVYRLRINGTEREVEAAADTPLLWVLRDQLGLTGPKYGCGVGACGACVSLVDDQAARMC
VLPVGELAGRAVTTVEGLSEHGDHPVQRAWVDGDVAQCGYCQAGQIMSTVALLRARPEPS
DSDIDEALRDNVCRCGTYPRIRKAVHAAAELAREEGR
>A0A7W9U2G8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bannensis|TrEMBL
MLPQTTERAGRRDFLKAGLALAGSFVLPLSLSTYVEAAPDGSAYREINDWVRVDPDGRTI
IGLSQAEVGQGVYTGLPQILADEMDADWRRVSVEFVTGRDAYRISAANEHPQQFVGASMS
VTMFHARLRVAGAQARQVFLEAGARRLGVRPTQCATKSGRVVHLQTGRSFSYGELLADAA
NLPLDPQPRLKAESARALIGQPLHKLDVPAKVNGSAVFGIDVKVPGMLAGFVKMAPTLNG
KPVAVRNRNAVRALAGVVDVVMAKDAVIVVADTYWQAKKAADTLDVQWQDAAPPADSATI
RAQNKAALMARQAAVATRIGDAPAQFDIAAKVVEADYHTPYIVHATMEPVNATVHVREHE
LEVWGPIQGQDKVRWTLGGIFKLPPEKVMVNTTFLGGSFGRKYVPDFVIHAAVASKAVGR
PVKVIRSREDDIRHGFYRPAASARMRAVLGANGYPTAMHLRVVGQSLYWSIKRDYFEKAG
GWDETMLDGLYDLGYAVPNLLVDSVSVDQHIPVSFMRSVGSTSSVFFLESFVNEMAHAAR
IDALEYRRTLLRGDPLAVRVLERTAARAGWSRKPAAGVHRGLAYCLYTGRGGAFTTYVAT
VVELRMVDGRAKLERIVCGIDCGRAVNPMLIREMVEGGIGFALTNTFKSEITFKDGAVEQ
QNFSDYPLLSLAQMPKIEVEIVESERTPQGCGEVALPPVAPAVAAALFEATGTRLRTMPL
EQELA
>A0A839PAP2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium sp. R2-1|TrEMBL
MLTLNLNGVVREVDADPDMPLLWVIRDRLDMTGTKYGCGIAQCGACTVHLDGQPVRSCQT
RIGDVGEAKITTIEGVQGKVADAVKAAWRGLDVVQCGYCQSGQIMSAIGLLTDNPKPSDA
DIDGAMDGNVCRCGTYQRIRAAIHEAALSLA
>A0A8H2NTV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPNDFALSNLSQLSRRGFLKGVGATSALVLAASWGWQDAFAGEKDKKFGADGMPHGW
VDDPKVYVSIAADGTVTVICNRSEMGQGVRTSLTMVVADELEADWAMVKVQQAPGDEVRF
GNQDTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHEPSGREL
GYGALASAASALPVPARDSLKLKQPSEFRYIGKEGTKAIDGEDIVNGRAVYGADVHFDGM
LYATIARPTVYGGKVKSFDGSAAMKVPGVVKVVQIESRPLPSEFQPLGGIAVVASNTWAA
IKGREALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNLEKAMASADSTLEASY
YLPHLSQSPMEPMVAIARFKDGACEAWGPSQAPQVSRERIGERLGLPFDKVTFNVTLLGG
GFGRKSKPDFIIEAAILAKEFPGKAVQVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPS
GWLHRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNIRLENPEATVHTRVGWYRSV
SNIPHGFAIQSFIDELAHKAGQDPLKYQIRLLGPDRQIDPRTLSEEWNYGESPERYPIDT
ARLRTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLVVHKADIA
VDCGPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVA
VHLVTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLSGWQKVGA
>A0A0B7DFW5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGATATGALVLAASWGWQDALAEDKPKQFGADGMPNGWIDD
PKVYVSIATDGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHKPSGRELGYG
ELAAAASALAVPARDSLRLKQPSEFRYIGKEGTKAIDGDDIVKGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVIKVMQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSSAASSLEASYYLP
HLAQAPMEPMVAIARFNNGVCEAWAPSQAPQVTRERIAERLGLPFDNVTVNVTLLGGGFG
RKSKPDFVIEAAILAKEFPGKAVRVQWTREDDVHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEARVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGVDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RAVLETAAKAAGWGRQLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E7MFK4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKFNGQDHSLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVIGQNVTTIDNLHADPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTQLKGVKA
>A0A5E6QXF1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLNDLFPEELPRALQHMLERDQVDGPATYARRSFLKILGIGGLALGAFPHLALAQQANGV
AVEPLKPTQQPNAFVQIASNGEVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
TSDIAYQDPRFGMHLTGGSNSIKNSYTQYRELGARARAMLLAAASARWEIDVARLNTRAG
HVLGPGGRTASYGELAEAAMAMPVPDQVSLKDPKDFRIIGQATTRIDAKAKSSGQQDFGI
DMRLPEQLTAVVARPPVFGARLAALDDSAARAIRGVKAVYRVPLDGGAEGVAVVAEGYWQ
AKQGRDALNVQWDTAAVEKVDSEQQLADYKALAGRPGPHHFDADMTPLATSPHTLEAEFV
FPYLAHAPMEPLNCTVLLSQGRAELWVGTQFAGADNAAAARVLNLKPEQVQINVQTAGGG
FGRRGIATSDIVVLACEVAKAARTVGLTVPVRTVWSREDDIKGGYYRPMHLHRAHIGFDD
SGNVLAWDHVLIGQSIVTGTMFGGRVKNGIDPTATEGMREPYPFPMRLTVHHPKLNVPVL
WWRSVGSTHTAFVMETLIDEIARTTQQDPVAYRMKLFADKSPRHSAALQLAVDKSEYGKR
QLPAGRAWGVAVHESFSSVVAYVVEASVQEGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
ALMGLSMCLPGGAITLKDGVVQQSNFADFSVPRIADMPEFSVHTLPSAEPPTGMGEPGLP
PLAPAFANAIARITGKPVRELPFKLA
>A0A379I7T4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MQTLIINGQSQQVDVAPDMPLLWVLRDVLGLTGTKYGCGIAQCGVCTVHLDGQPIRSCVT
PISAVAGRAITTIEAIGETVVGQAVQQAWLAHEVVQCGYCQSGQIMAATALLQSQPKPDD
QAIDAAMAGNLCRCATYTRIRTAIHSVGQVEEA
>A0A0M7AKY4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii|TrEMBL
MLHLLQNPLEAPKPSRRTFLKMSAGAVGGLIIAAKMPNAAKAAADAGEFVQPFVHIRPDN
TVVVLSKHLDKGQGTANGLATLVADELDASHEQIVLELAPSNPQLYANSLFGVQGTGGST
AMPNAFMQYRQAGAAAKAMVVSAAAKEWGVPAGEITVSGGVVSHSSGKSATLGELAGLAA
NEDVPVEPALKTPGQWVYIGKSFPRKDVKNKTVGAPNTYTIDFNREGMLTATVARSPRFG
GTVKSFDAAEAKTVAGVVDIIQIPNGVAVVAESTWPAIKARDLLEIEWDDSAAETRSTDA
MMTELKDMTTKPGLKVREDGDVDAALEASAKVMEIDYDFPFLAHGAMEPLDIVGEFDGET
AQFWFGSQIPTIDHNVASTILGIPFEKVSINTLWAGGSFGRRAQGDAHPVSEISFLLKAM
REAGMEPRPVKIVWTREDDMAGGYYRPMSAHKIKVGLDGDGNVTAVKYNIAAKSIIKGTA
FEPMLMPNGVDHNMTEGASDTTYSFPMMNMDQAFQETPVPVLWWRSVGHTHTAYVMETMI
DRIAKETGKDPVALRLELLKDDPRKTNVLKLAAEKAGWDTPLPEGRHRGVAVHESFGSYV
AEVVEISFREDGTVKVEKVTAAVDCGVPVNPDNIRAQVEGGIGYGLGAILRNQVTLSDGY
VEETNFDTYESLRISDMPEIAVHIVPSTDSPTGIGEPGTPPIGPAVANAIAAAKDEWITS
LPFTKAGLV
>A0A5E7SM92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNVRIDPSLQASALDLREPINVSRRRFLTGTAVGALVLGFGLPLGATRVQAAVAAATAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPSTFLVEAAPPGEAYV
VLENGMRITGGSMSVRMSYPVMRRLGALARAMLLQAGAQQLGVPVSELTTEPGKVVHAKS
GRSLAYGELAERAMDLPVPDPASVTLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKV
DNMLHAAVQHAPRLGMTVGNLRNEDQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTAESKVRPMPADFSSDAWFKRLAEDKGPAKDDENQGDVASIFKDTKTRIDATY
HNQYLNHGQLEPPSALARFNPDGSLEVWLPNQAPDMFRADIAKRTGLDTSRITLHSPLLG
GFFGRHFLYDSASPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRGALDAEG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKSYAIPNMRIAQIYAKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFDLRLHLLRDNKRLTTLLQAVGELSGGWKRGPF
TAEDGSKRARGVAMASPFGTETAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEEAVWIDGKPRARNYDLYPILPPARMARVHVRVVESGEKMGGIGEPPL
PAVAPAVANAVARLTGQRVRSLPMSRHTFT
>A0A3S4RLF3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MTRFELNGRDVSVEVADDTPLLWVIRDDLGLTGTKFGCGIGLCGACTLHIDGRAIRSCIT
PLGAVANARVTTIEGLDPKGQHPLQKAWIATQAPQCGYCQSGQIMQAATLLKDFPDPSDQ
DIDAVMNGSLCRCMAYVRIRQAIKLAAAELRSGTVHEGTAHE
>A0A5E6UW36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIESDEVGKRVVATWVDLQVAQCGYCQSGQVMAATALLKQNPKPSDA
QIEAAMVNLCRCGTYNAIHAAVHELAGKGDA
>A0A379IH65|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGSVKGQNVSTIDNLHNDPVGQVVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
AQIEEAMVGNICRCGTYNRIKTAIRQAATHLQGAKA
>A0A5E7WBF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVIGQNVTTIDNLHADPVGQVVQQAWLDSAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A6J5DRI1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia solisilvae|TrEMBL
MVKRRTFLVGGAAALGTLAVGWSALPPRQRLDPARALDVLPAQAALNGWVKIGADNRVTV
MVCRAEMGQGVHTGVAMLVAEELDADWSRVGVEAAPVDRIYNNVESVVGNLPFRPDDDST
LKGVVAWLARKGAREIGAMMTGGSTSLNDAWLPMREAGAAARVMLIQAAAAQWGVPVAQC
RTEAGRVFDGPASGATRSATYGELAPLAARQPLPRKIEVKDPAAFTLIGKPLLRIEAPSK
LDGSARFGIDAAPERLLYASVAMCPVPGGAVAHFDGAAAAAQPGVISVFAVPPYHGGTGG
VAVIAGNAYAAMHALEAVKCEWRIDDASRVSSADVFTRLGDALDDSAGHTWYARGDADAA
LGIAARTVHAEYRVPYLAHAALEPINCTAQVNDGSAIVWAATQVPDVARRYTAQMLDLPE
EQVDIRSMLIGGAFGRRLEMDYIAQAVAIANKMRGTPVQTIWTRPQDMMHDFYRPACVSR
LSAGLDNAGAVIAWRNTSASQSIVTHWLARNYGVPGFAAELGRAFDKTNDEGAFDQPYEW
PNLRVGHKAVSLPVPVGFWRSVGHSHQAFFVESFVDELAAAAGKDPVAFRAAMLAHHPRH
LAVLRRAAQLAGWHAPLDTDERGLAQARGVALHDAFGSVVAQVVEVSVDAPVEKGKERTI
HVNRVVCVIDCGLPVNPNLIAQQLEGAIVFGLSAALYGAITLDGGVVQQQYYTDYPVVRM
AQCPRIVTDIVASREHPQGVGEAATPPVAPAVANAVFALTGVRLRTLPLMLA
>A0A1R4B0W6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Vibrio palustris|TrEMBL
MTKFILNGEPVAVDVDGDTPLLWVIRDELNMTGTKFGCGIGTCGACTVHVGGRATRSCTT
PVSAVENANITTIEGLSEEGAHPVQVVWQKHQVPQCGYCQSGQIMQAVALLEDIPNPSDD
DIDAVMSGNLCRCMTYVRIREAVREAANTMSMKQGGNDEQAV
>A0A7Y7H764|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mucilaginibacter sp. SG538B|TrEMBL
MIAITINGKQREVAADPDMPLLWVIRDLLGLTGTKFGCGVAQCGACTVHLNGEAVRSCVT
KVSRAAGQQVTTIEGLSKLNDHALQIAWAELDVPQCGYCQSGQLMSAAVLLRENPNPTDQ
DIDDAMSGNICRCGTYPRIRLAIHKAAELQREGAKS
>A0A7Z0BB59|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MRHDNEALTSARGAARRRFIKQSSALLASGLAIGFQLPEALAKGENASGDPQPLPGEFEP
NAWVRVLSDDTIKLVVHKHDSGTGTRTALAAVVAEELDVDPFRVDVITPENPFFGEYIHP
LWKVFSTGGSTSVSLEYDRLRRAGATARAMLIASAAKQWNVAPSALTTDNGFVVDPASGK
RASYGSLASVAAQLPAPKDVALKDPSQFKYIGKLQKKRGAAQKAMGAFPYSIDVSLPGLL
VATVTRAPVINARVRSVDAKDALAVPGVRQIVQIPGRPDILGGNQAGVAVLADDYWSAHK
GQAALRVEWDDSPLETFDSSTLAAQQARWLDDPAARVVPTIQHGDAGTAWPHGAHVIEAA
YSMPYKAQNPLEPINVTAWAKDGGIEYWGGLQVPSTVQEAAEVIGSIPADRVVLHELVSG
GSFGSRESKYWLFEVTWLALKVGKPVKLMNSREDEMRALYYHSASYHRGKAVLDTHGNLS
TLQLRAVMPASPEQWEPGYFDRPDRMDYSTTEAISKYEFAYDAPHVDIGWVRHETGVPTG
WYRAVSYIPNVFAVESFMDEAAHAGKRDPVDFRLAHMKDPRHQAVLREAAARAGWGKPLP
PGTALGVATNQAYSSYVAVVARVRRNGDGVVIDKLTCIADCGLAVSPGGVEEQLYGGLMW
GLGHAIGDRIDIRHGQVEQKNFDTYRVMRMTDMPEIDIQIVQGDPAKPGGVGELSSPSVA
PAVANAVFRLTGQRLRDTPFDLGKVGAHAGAKVKVSA
>A0A7Y9W7U7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MIEIVVNDTRHSLDNVPEDMPLLWVLRDRLKLTGTKFGCGGGFCGACTVHLEGEAVRSCL
LPVVAVAGKNITTIEGLSKDGRHPLQLAWVAEDVPQCGYCQSGQLMQAAAFLKDKPTVND
ETISTAMSGNICRCGTYSRIRKAIKRAASGDPALAEVVMPSCTSACASHAAAEEA
>H0T6J4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MNQHVTPRLNRRSFVIGTAALGGGLALGLDLPFGGPQVVRAADGSPEVNAWVVIRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELACDWSKVTTEYPTPGQNVARKRVWGDFSTGGSRGI
RASQDYVRKGGAAARMMLIQAAADEWKVPAAECTAANSVITHKASGKTTTYGKVAEAAAK
LSPPADVKLKDPKDWTLIGKGVKRLDTADKVTGAMIYGADIKLPGMLNAAIKDCPVTGGK
LKSYDEAKIAGMKGVKKVVAVDGTAVAVVADTWWHAKTALDALPIVWDEGPNAKVSSASI
GKWLAEGLDSGPAFVGNENGDAKAALAGAVKKVEAVYNYPYQNHATMEPMNATALYTADR
CEVWCGTQNGEAAFAAVLEASGLPADKCEVHKLILGGGFGRRGQTDYVRQAVQIAKAMPG
TPVKLLWSREEDMTHGRYHPITQCKLTGGFDADNNLTALHMRISGQSILFSLRPDALVNG
KDPATFQGLAPSGEATIGYSVPNLLIEHAMRNPHINPGFWRGVNVNQNAIYLECFMDELA
NAVGQDPLEFRRKLMAKNPKHLAVLDAVAEKIGWGTPAPEGVHRGLAQLHGYGSYVAGAA
EISVIDGSKIKIHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGRIEQT
NFDSYNSMRIAEMPKVEAIMVPSGGFWGGVGEPTIGVAAPAVLNAFFAATGKRIRSVPLR
DQNITFA
>A0A7W7EVT8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium taihuense|TrEMBL
MTDAISLSRRSFIATSLAGGAVLTLDASVVLAATTTTAPSDVLNAFVRINADNSVTIGAK
NPEIGQGVKVMLPMLIAEEMDLAWEQVRIEQTDADETRYGPQVAGGSTATPRNWLPMRQV
GAAARAMLVAAAAKKWSVDPSSLSTAKGAVIHAASGKSATYASLAKAAAAEAAPDLAKVP
LKDEKTFTIIGKSKPGVDVPKIVTGQPLFGIDTRLPGMVHAAVVKCPAHGGTVASIDDAA
VKAIPGVLAVTAVNSGFVPEGKSDTVVIIADSWWKASKAREKLGVKWDDATVTGFTTAKY
EADAAKLVTAAPQASLLKTGDADGTLAKAAKVIKADYDYPFLAHASLEPQNCTALFKDGK
LEIWAPSQAPAGGRAETAKLCGLSPDDLTIHLTRMGGGFGRRLMNDYMVIAGQAAKALPG
KPVKVLYDRTDDFRHDFYRPAGWHRFTAGLDASGALVALKDHFVTFGKDGKPIRAAQMAP
TEFPAPVVPNVDLGISYMATNLATGWLRAPTSNAMSFVWQSFMDEVAEAAGLDLPEFMRR
TLGAPREIPGERVGFHTARARGVIDAVCKSAGWKGREKGRGFGFYFSHLGYFAEIVDLSM
KNGAVSIDKVWVAGDIGAHVINPINAMNQAQGCVIDGIGQALIGQKIVQEAGAITAENFG
DFALMRIDAAPRAIAVEFVKTDFPPTGLGEPALPPVIPALANAIYSLTGKRHRRLPLEMV
>F4L141|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MATITLTINGEKRTVNVESDTSLLWVLREHLGLTGTKYSCGKSYCGACTVHLDGVPIRSC
TTPVSVAEKRTITTIEGLSTNGDHPLQKAWVEEQVAQCGYCQSGQIMQAAALLASNKKPS
REEIINQMSGVLCRCGTYMRILKAIERAAKEI
>A0A6M4GYQ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MPTTINLNGKAVSVDASPDTPMLWVLRDHLGMTGTKFGCGASLCGACTVHVDGVPARSCV
TPMSAVAGKKVTTIEGVSGKVATAVQAAWDKVQVPQCGYCQSGQVMAATALLTKTPNPTD
AQIDEAMSGNICRCGTYGRVRTAIKDASKSLGGKA
>A0A6M4GUV6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter rugosus|TrEMBL
MSALPVTRREFLKVSAVAGGGLMIGINLGASSTAEAAATAAGFENAWIKITPDDKITFIC
HRNEMGQDVHTSLAMMLADELGVDPRKVTIVQAGSNPKLYINKLLGGQITGGSTSIRDAW
EPVRMAGASARTMLVGAAATEWKVPVTEVKTENGMVVHGTKKISYGKLATAAAKQPVPGS
VAMHSKSQMTVIGTNVPRLDGADKARGKTVFGIDVKQPGMLYAAMQHSPVIGGKAVSVDS
AAAEKMKGVKKVVNIGDGVAVIADHYWSARQAADALKVTWDDGPSAKVSTASVWATLEKA
KDRPGFVAGKKGDVTGPLASGAIEATYSCQMLSHATLEPQNCTARVTKDGIDVWAPTQFP
QGAEGTAAAVSGMKAEQIRIHPQFIGGGFGRKLENDFIAQAVLIAKAMPGVPVKLTWTRP
EDMSHDFYRPPSLHVMKAAVKDGKVVAFASKMISPSVTARAFPSVVKDGNDPFMTEGLVN
FTYDIPNVELRSVIEEVGVRVGYWRSVSNALNAFATEGFMDELAQSAKQDPLAFRLAMLN
GMPAQKAALQKAAELSGYTATPAKGRAFGVASMECYDTHCAMIAEVSDQGGKVKLEKITV
VADAGLIVHPDQAVAQLEGGIVTGLISTLRSKITLKDGRVEQSNFHDFQLPRMTDVPPIQ
VAFVGNRDKPGGLGEVGVPLVAPCVANAVFNLTGKRIRALPLEDGGVTFA
>A0A3M3XF90|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MTTRNPPLDAPLGEPINLSRRRFLASTAVGALVIGFGLPLGASRAYAATGGPAERGTQVP
AFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFVVEAAPPGEAYVVMENG
MRITGGSMSIRMSYPTMRRLGALARAMLLQAGAEQLGVPLAQLTTQPGRVVHAASGRSLG
YGELAGRALDMPVPDPATITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYSIDLKVDGMLH
AAVQHAPRLGMTVGSLRNQSQVEAMKGVHSVHQLPGAVAVVAERWWHAKRAVEAIQVEWL
EAAAGSSVRAMPADFSSDKYRDFLAAQQGPARDDENEGDVAGALTNAKTKIEATYHNQYL
NHAQLEPPSALARFNPDGSLEVWLPNQAPDMFRADMAKRTGLSIEQITLHSPLLGGFFGR
HFLYDSANPYPQAIALAKAVGRPIKLIWSREEEFLRDVLRPVAVVKFRAALDDKGLPVAI
EAVSATEGPSEAIAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGN
SLNDFFYEAFLDELADKGGHDPYELRLHLLRDNKRLTTLLQAAGELSGGWKRGPYTAEDG
TRRARGVAMASPFGSHAAVIAEVSIESGQVKVHHIWEAIDPGSIVNPAIVEAQVNGAVAL
GLSQTLLEEAVYVDGKPRARNYDLYPILPPSRMAQVHVRIVESGEKMGGIGEPPLPAVAP
AVANAVAHLTGQRIRSLPLSRYTFS
>A0A2U3QBI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium vignae|TrEMBL
MHMATTLSINGETKSFDAPPDMPLLWVLRDILGMTGTKFGCGIAQCGACTVHIDGKAVRS
CVLPVSAVENRNVTTIEHVGSTPAGAKVQKAWLEAEVIQCGYCQSGQIMAAAALLAATPN
PDDSDIDAAMAGNICRCGTYVRIREAIKQAANGRQS
>A0A5P2X224|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces spectabilis|TrEMBL
MPEHTFGLNGEQVTVEAADDERLLWVLRDILGVTGPKYGCGINVCKACTSHLNGKAANPC
AIRVKDLRPGDEVTTIEGLADTVEAELHPMQQAWLEQDVVQCGYCQPGQIMAAVALVRRV
AQEGREITDADLDGIRNICRCGTYFRIREAIRAGAARM
>B1GAS8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MTTFNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDKKITTIEAVGNTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAIKHAAKGV
>A0A654B381|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas titanicae|TrEMBL
MTAFTINGRAVDVTAEPGTPLLWVIREQLKLTGTKFGCGIAQCGACMLHVDGEPVRACVF
PLSGAEGRSITTIEGLSEDGSHPVQQAWVELDVPQCGYCQSGQIMSAAALLARNPRPTNA
QIDDAMSGNLCRCGTYVRIRAAIHRVAES
>A0A2N7WAG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia rhynchosiae|TrEMBL
MSTSFFLNGKNVTLNADPATPLLWAIREDAGLHGTKFGCGMAQCGACTVHLEGQATRSCM
LPLAAVAGKHITTIEGIASRPAKAIQAAWVKLQVPQCGYCQSGQIMSATALLEQNATPTD
ADIDAAMNGNLCRCATYTRIRAAIHEAAATLKA
>A0A179R2C6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MELRINQKTYQVEADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIEADPVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPKPSDA
QIDAAMVNLCRCGTYNAIHAAVHDLAQGEQA
>A0A653M5G8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. 62|TrEMBL
MAHTITVNGTRHSVDVDDDTPLLWVLRDTLQLTGTKFGCGVAQCGACTVYMDGQPLRSCS
MPVSAIGEAKITTIEALSGKEAEAVQAAWVKHDVPQCGYCQSGQVMSAIALLKEIRKPTD
RDIDLAMNGNLCRCATYVRIRAAIHDAARTLEG
>A0A0P1F8C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassobius gelatinovorus|TrEMBL
MSRAGKIARRTFLIGSTAIVGGVAFGVYRVKTPYANPLQDALADGAASFNPWVMIDADKI
TLIGPHADKGQGVASSQAALIAEEMDLDFGQFEISFGTPDKAYWNTAMAGEGVPFMSTNE
SFTAETMRDVMSGGIKLLGMQLTGGSSTIPDSFDKLRRAGAMARETLKLAAAQKSGVPVA
QLKTAQGAVQLPDGTDLKYTELAAIAATLDPVRDAHLRDPGQWRLIGKPMHRLDMTAKVT
GTQTYGIDLKIDGMVHAAVKMNPRQGGALAGYDAAAAQSMRGVQKVLPITGGVAVIADNT
WRAFQAAQAIEFDWGPAPYPAEQDDHWTEIGNSFTKDRLDKTWRDDGDVETELAKGSVVA
AEYRSPYVAHQPLEPLNAVVKVTDDAVDVWSGNQIPRQLQQIVAKITGHKAAQVRFHNQF
IGGSFGHRLEFEFIKQATEIANQMRGTPVKLTYSREEDFAHDFPRHIAMARGTGTVADGK
VVAMDLDIASPSVMSSQMGRAGLPVPGPDMQIVAGAWNNPYALAHLRVRGYRVPELAPVS
SWRSVGAAGAGFFFDSFLDELIHRAGADPMEERIRLMGHDLSRRVLETVAEMSSWGGELA
ANKGRGVAFVESFGVPTAEVVEVTNTENGIRIDKVWVAAEVGRVVDPVNFENLVQGGVIF
GLGHAMNSQITYADGMAEQSNYWDAEAMRMAQCPEIFVKGLENGPHVRGIGEPPVPPAAP
ALANAIFAATGQRLRALPFNQGIDFV
>W6WA45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. GM30|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A9DDW0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hoeflea phototrophica (strain DSM 17068 / NCIMB 14078 / DFL-43)|TrEMBL
MKISVNGQTHEVDVEPDMPLLWVLRDELGITGVKYGCGIAMCGACTVHIDGIPTRSCQQW
VGDVEGEITTIEGLGTPDALHAVQAAWIKHQVAQCGYCQSGQMMSAAALLAENNDPSDQD
IDDAMSGNLCRCGTYPRIREAIKAAAQTIRSA
>A0A1E3GNM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylophaga muralis|TrEMBL
MKLSINGASHEVNLPEEMPILWTLRDVLGLTGTKFGCGKALCGACTVMLDGQPIRSCSTP
ISAAKDKQITTIEAVSEDKVGRAIQQAWVELGVPQCGYCQSGQVVSATALLRTNSNPSDT
DIDNAMSGNICRCGTYNRIRDAIKLAATKSGDAQ
>F8GX77|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MLRLDVNGTAHTIDCEASTPLLWVLRDHLNLTGTKFGCGAGQCGACTVHLDGAAVRSCVL
PAIAATGRQVQTIEGLASGNPHPLQDAWIELQVSQCGYCQSGMLMAAAALLAINPTPNDA
DIDAAITNLCRCGTYGRVREAIRRVGACSAKCAKELPV
>A0A3M2RA68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter litoralis|TrEMBL
MTMNRREFMKVSTAASGSLVLAVSLPGCSTIKTGFEEETGQWSPDIWLELTTNDDIFFTL
ARVEMGQGTYTGLTTLVAEELDVDPARIKVKFAPVAPEYRNPLFGLQLTGGSTSVATSWI
PLREAGALARQMLVMAAARVWKVDAADCTTQDGRVVHPNGIDSLRYGQLVELADKEIVRG
DVALKPRSEWKYIGRQAGRLDTEAKATGKAVYGIDVELPGMVYAVMTRCPRYGGKATGFN
RSDVMAWPGVLDAFITERGVAVVADRYWRARKAQEALRVEWDFAEAINLDNDQVFEGYRE
AANEDAGAQERSDGDFDDAVENASRVVEAEYEQPYLDHAAMEPMNATAWYRDGGMEVWAP
TQAPDLARIAAARHSNLSPGDVTVNTTFLGGGFGRRLTQDYVEEVAIVAYKIKKPVKLIW
SREEDVRHGFWRPAMLHRMKASFNDAELTGWDHQIVGPQILDWYVRNAAPAQYPWAPKFL
YSTLGRVGLMAEGIATPKDISAIEGAVGYPYQVENVSVRHTHTDPGVPITWWRSVGYSHN
GFAVETFMDELAHEAGEDPLQFRRKLLANEPRHLAVLERAAEMAGWGSPVAEGRARGIAL
FKSFGTYVAQVVEASIQHGEIQVHKVTCSVDCGQVVNPRVVEDQISGGILFGLSAALFGE
ITFKNGEVQQSNFHDSRVLRMHQVPEVVVDIVDSEIAPTGVGEPGVPPVIPALGNALFAL
TGKRQRRLPLTAG
>A0A7W8BK06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces albaduncus|TrEMBL
MPEHTFRLNGEQVTVDVDDDVRLLWVLRDILGVTGPKYGCGINVCKACTSHLNGKAVNPC
AVPVGALRPTDEVTTIEGLPATAGADLHPMQQAWLDQDVAQCGYCQPGQIMAAVALVRRV
TDEGREITESDLDGLRNICRCGTYVRIREAIRAGADAMRRL
>I0HRM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubrivivax gelatinosus (strain NBRC 100245 / IL144)|TrEMBL
MAIDIEVNGRIRRVDADPETPLLWVIREELGLTGTKYGCGIAQCGACTVHLDGETRRSCS
TPVAAAVGHRVTTIEGLASPTAKAVQQAWIALDVVQCGYCQSGQIMSAVALLERLPRPSD
EDIDLAMAGNICRCATYQRIRAAIHVAARQLS
>A0A7Z0IRM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides panzhihuensis|TrEMBL
MPEQTFILNGEPVTVDVEDDVRVLWVLRDILGVKGPKYGCGINVCKACTSHINGKAFNPC
AVPVGKLGAKDEITTIEGLPGEVPESERGEHGLHPMQESWLDNDVAQCGYCQPGQIMAAV
ALVKKVRAEGRTITDGDLDGIRNICRCGTYTRIREAIREGEQRM
>A0A061D6Z7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas oleovorans|TrEMBL
MGKIETPDSATRGILNVSRRTLLKGAGGLALGIFFAPLMRGMDALAAGGPLEPNAFVRID
LDGTVTVLAKHLEMGQGSYTGLATLLAEELDADWDKVRVEGAPADVKRYNNLAFGPMQGT
GGSTAMANSWEQMRNAGATAKAMLVAAAAQRWSVPVSEISVDKGVVSHAGSGRSAGFGDL
VEAAASLPVPEQVQLKDPKDFKLIGKLELRRKDSTDKTDGSAIFTQDFKLPGMLVAMVAY
PPRFGGVPRSVDSSKAKAVRDVVEVVEFRDLPHGRSGVAVLAKNTWAARQGRDALVIEWD
ESQAFTLGSEEILAQYRDDAGKPGLPATSKGDTDAALAQAAKTVEADYEFPYLAHAAMEP
MNCLVKLSSDRCEIWNGEQFQTVDQTIISGYLGLTPEQVSLTQLYAGGSFGRRASSVSDY
LLEAVAITKAARDKGVDAPVKMVWTREDDTRGGYFRPLYLHRVRIGLDQAGKLQAWHNRI
VGQSIMAGTSMEPFMIKDGIDHTSVEGLANLSYAVPNLQVELSTPSNIKVPVLWWRSVGH
THTGYVAETMIDEAAVAAGQDPYAFRHALLESHPRHRGALELAAKQAGWDKPLAAGAEGE
KRGRGIAVHESFGSFVAQVAEVTVKADGSYRLDRVVCAVDCGIAINPDVIKAQMEGGIGF
ALAAARHSAITLKEGRVEQSNFHDFQVLRMNEMPKVEVHIVPSAANPTGVGEPGVPPLAP
ALANALFAATGVRLRKLPFPAQIKA
>A0A0P7ZGP8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter sp. HL-58|TrEMBL
MSMNRRDFLKVTAGTSGGLVLALSLKGCAGVPTGYDEQSGEWKPDAWLELTASDEIYFTL
ARVEMGQGTYTGLTTLIAEELEVTPASIKLRFAPVATEYRNPLYKLQLTGGSTSLATSWQ
PLRIAGASARTMLVSAAASVWEVSPGDCRASEGRVVHPNGQDSLPYGRLVELASKQNVPG
DPALKPRGEWKYIGKNRGRLDAEAKTTGAPIYGIDVELEGMVYGVVTRPPRYGARVRSFD
DSAARKMPGVLEIFEIERGVAVVADKYWRARKAQEALTVDWDNSEALDVSTDQVFASYHK
AADEDPGESERSEGDYRRAVDNAGQVIEASYEQPYLAHATLEPMNATAWYRDSEIEVWAP
TQAPDLGRIAAARATDLSPDDVKIHTTFLGGGFGRRLTNDYIEEAAAIAFRVHKPVKVIW
SREEDTRHDLYRPAMLHRMQASISDNKVTGWHHQIVGPQILDWYVRNAAPAQYPWAPKFL
YNTLGRVGLMAEGIATPKDHSAIEGAIEYPYRVPNLDIRHTHTDPGVPVSWWRSVGFSHN
GFAVETFMDELASELGQDPYRFRRSLIDHEPRHLQVLDRAVGLAKWDEPVEEGRARGLAL
YRSFGTYVAQVVEASVEAGEIRVHKVACAVDCGQVVNPDIVRDQIEGGVIFGLTAALYGD
ITFRDGQVQQSNFHDYPLMRHDQRPEVVVDIVDSEEDPTGVGEPGVPPVIPALGNALFAL
TGKRQRKLPLRAEV
>A0A853B6U6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis endophytica|TrEMBL
MSQHTFTVNGKRVTVDADDKVRLLWVLRDLLGITGPKYGCGINVCKACTSHINGKAFNPC
SVPVSAIGPDDEITTIEGVADPETGELHPMQQAWLDRDVAQCGYCQPGQIMAAIAKVKQA
RAAGREISDADFDEIRNICRCGTYSRIREAVRGAAAQM
>A0A0K0Y4V8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Octadecabacter temperatus|TrEMBL
MGRLKTIARRTFLFGSAAIVGGVAFGTYLYKKPVANPLLDDLGENEASMTEYVRITADGV
TLITPRADKGQGVYHVQAALIAEEMDIDLDQVTVEPGPPSPAYYNTALSAEAPGFMPTDE
GFAANSVRTVMDAAMKIMGVQITGGSSTVADSWEKLRVAGAVARETIKAAAALETGVDVG
EMRTARGAVILPDGSELTYIELAATAATLDPVDAVALKDPSEWRYIGKDMQRLDIVPKST
GTQTYGIDMELDGMVHATVITNPRKDAAMLGFDSSEAETMRGVLKVVELPNGVGVIADNT
WRAFQAAQAISFDWDAATYPAEQEDHWAALADSFKDDQRDSRYRDDGDVDDALDSADVID
VEYRAPYVAHAPLEPINATALITDTRADIWTGTQTPRFAQSAVAELTGLDDADVHIHVLM
MGGSFGHRLEIEVVKQAALLGIAMKDTPVKLTYSREEDMAHDYTRQIAMARMRGSVKDGQ
VDTLDLGIAMPSVTSSQMGRLGLSVPGPDPMIVAGAWDQPFGIPNYRVTGYRSEPLAPIS
SWRSVGASTNGFFHDSALDELIHAAGADPMEERIRLAWDDNSRAVLEAVAEMSGWDGPDM
GPSRGRGVAFCMSFGVPCAEVVEVTNTDRGIQIDKAYAVANVGRIIDPINLQSQMSGAML
WGLGHAMFAEITHSDGMTDQINYDGFQAMRQYQAPEIQVRGLELGDHVRGIGEPPVPPAA
PALANAIFAATGQRIREMPFSRHIDFV
>A0A385ZQS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces griseorubiginosus|TrEMBL
MVYSLAASTLTVAAPLGCDAAPAEGAEPTAPAPRRSSDVLVTGADEEMLVLEVTEANKVV
VRLPRVEVGQGVTTAVAMMIAEELDARIADVEIPLAGARTRGNQFTGGSSSVSSLYGPAR
ELAALARAKLVTAAAKQWRLPARFLYTRNTRVFAPDGRSATFGSLTASAARITRPTVSSR
PKPASRHRVIGRPTTRIDARDIVTGKAEYAGDLAVAGAKPTVVARPPTLGGKLVSVDSRA
ARAMPGVHAVVKAAGGVAVVADSFHHAFQARDALRITWAPGPLASLSDAEIRSRLRAAVP
RLGTPPRGSTQTEGEFEFAFVSHAPMEVLTAVADVRADRAEIWFSSQTPMDARDSIASAV
GLPAAKVKVHVIRGGGSFGRRLNHDAAIEAALISKAARRPVKLMWSRADDIRHGRMRPAS
HHRIRASHAGGRVVAFSHVTASVSESYEGKGLLSAQGGVGDAVAPALATAAGPLPSDDGL
YNFGRVSGDSGSVDLAIPLGAWRSVDSGTMRTAEEIVVDEVARSLGKDPVAFRRTTLRNK
SVKAVLDKVAAAGDWGRTLPASQAQGVAVHEEYGSCVACLVEIDAGDPKNPRVTRVVMAA
DVGTAVNPRGLEAQLMGTAIDGISTVLTAGLHIDRGAVRESSYADFRYARQRHAPLRFEA
HIMPSRREPGGAGELGVPAAAGAVANAYARATGARPRRFPLTF
>A0A6I1PZ98|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia atlantica|TrEMBL
MAVLNINGRKVLVNADPDMPLLWVLRCDLGMTGTKFGCGVGICGACTINLDDAACLACQT
PMSSLHTQKITTIEGLQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKHKPDPTDA
DIDEAMTPVVCRCGTYPRVRAAIHQAAKARKS
>A0A128FCS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia marina|TrEMBL
MRDFLNGYVPEEAFFKNTKQVGTSRRNLIKLMSTAGAGLTLGVHLPSVAAGANETAGKPF
EPNAFVRVGSDDTVTIMIKHLDMGQGVTTGLATIAADELDADWSKVTTEAAPANANEYNN
LLFGPVQGTGGSTAIANSFMQLRMAGAKAKIMLVNAAAKVWEVPASEITASNSTLSHSGT
NKSASYGEMAELAALQSVPPDDQVVIKTPDQFTIIGKTGTARKDKGKSNGTATFTQDVQL
EGMLTALVAHPPAFGAKVVSFDATAAKQSPGVVDVVQIPTGIAVVAKDFWSAKTGRDKLS
IKWDRSAFTKNTEQMKTEYTALAQTPGLPARNDGDAGKALESAENVVEATYYFPYLSHSP
MEPMNCVVLVGDDKAELWYGAQIQTVDQFAVATVLGIKPENVTINTLFAGGSFGRRANPQ
ADYVVEATMIAKTQPGVPVKLVWTREDDMRAGYYRPMYIHKIRGAVDNQGNITAWKQRIV
GQSIAAGTAFEGFMVKDGVDSSSVEGASTLPYAIPNLAVELHTVQQPVPVLWWRSVGHTH
TAFSTETFFDELAHKAGKDPVELRRALLKNHPRHLGVLNLAVEKSEWGVRREVV
>A0A564FRZ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium dankookense|TrEMBL
MFKLTVNGATHEVDADPDMPLLWVLRDRLDKTGTKYGCGIAQCGACTIHLDGQPVRSCQT
RIGDVGEGKITTIEGVSGRVAEAVQGAWRKLDVVQCGYCQSGQIMSAIGLLSTNPKPSDA
DIDGAMDGNICRCGTYQRIRAAIHEAARSLA
>A0A085FYN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. LC238|TrEMBL
MVTLNINGRDLQVDADPSTPILWALRDNLNMTGTKFGCGAALCGACTVHLDGNPIRSCVT
PISAAQGLKITTIEAMENDKVGKAVQDAWVKHDVPQCGYCQSGQVMSAVVLLRTNKRPSD
ADIDNAMSGNICRCGTYQRIRAAIKDAATTLA
>A0A448EK68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica|TrEMBL
MAEVLSTKAVGKEANTAASTQTFSTQTLSINGKSFTLDADPKMPILWALRDILGLTGTKY
GCGAGLCGACTVHLDGQPVRACLTSLGQAQGKQLTTIEGLDNQKLKNAWAEHNVPQCGYC
QAGQLMSAAALVAQHPKPSEEQINSAMSGNICRCGTYPRIKAALQNYAKQEG
>A0A0M4MWY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Altererythrobacter epoxidivorans|TrEMBL
MSRMTINERPVQFDMDPDTPLLFALRDAANLTGTKYGCGNGDCGACTVIVDGAALRSCLI
TIAEAEGRFITTIEGLSDDRSHPVQQAMVAEQAVQCGFCTPGIVMAAAALLQNNPSPTEA
DIKAAVPNLCRCGVYPRLVRAIERAGRVSRRRETISAAPAPGISAEDAAKAVPAMRPLPR
NEEAGTSEGN
>A0A7W8T3L7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. MM5384-R2|TrEMBL
MSQGLLDAQNGAQPADTDARHARGISRRGFLKFGVTVGAAAGGGLLLGFSMPAASQDQKA
GKSVIGGDANEAPQSGVFAPNAFIQIDNAGKVTLVMPKVEMGQGVYTSIPMLIAEELEVP
LGTVTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARVMLINAAAQQWQV
DPASCHAQAGQVIHPASNRSASYGQLAQAASALPAPQNVPLKDPKDFKLIGTPAKRLDSP
EKVDGTAQFGLDVRLPDMVYAAIANCPVFGGTLASVDDTHAKTIPGVREVIKLDNAVAVI
GAHTWAAKRGLQALDIKWNEGAGAQVSMKRIVDDLAAASQHGGAVARKDGDVGRAFGEAK
SRVDAVYQQPFLAHATMEPVNATVHVRGDACEIWLGSQVPTRVVDAAVAVTGLPADKIIV
HNHLIGGGFGRRLETDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDTISAGLD
ANGKPIAWQHRIAGSSIMARFAPPAFRNGLDPDAVEVAADLPYDLPNQLVDYVRVEPHAV
PTAFWRGVGPTRGTFVVESFIDELAAHAKIDPVQYRRDLLGKSPRALNVLNLAAQAGNWG
SALPKGQGRGISVMHAFGSFFAIVVEVALEQGEVTVKRVNCAVDCGMFVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRINQTPPIDVHIVKSGEAPGGIGEPGTA
ALAPALTNAIYAATGTRLRQLPVGRQLHSA
>A0A1J5PEH7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MANLTINGKSFDVDVEPDTPLLWAIRENIGLTGTKYGCGIAQCGACTVHVDGVAMRSCGM
LVSEAVGKKITTIEGLADNGALHKVQQAWIANDVPQCGYCQSGMIMAVAALLKEKPKPTD
KDIDEAITNICRCGTFQQVREAIHAVAKA
>A0A0J7J8N9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter subterrani|TrEMBL
MVTLTINGEQHELDVPDTMPLLWVIRDVLGMKGTKFGCGIAQCGACTVHMAGTAIRSCVT
PVSTVAGEIQTIEAMAEDPVGSKVQQAWLDLGVAQCGYCQGGQIMNATSLLKQTPEPKTQ
EIVDAMAGNLCRCGTYNRILAAIERAAGKEVSS
>A0A7Y9XUZ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium marinum|TrEMBL
MHVSRRGLLIGGAAAGGLAVAWLLRPRDWPLPLDPGRNELAFGAWLKVAIDGVVTVAVPQ
LEMGQGITTLIPQVVAHEMGADWRQIAVEPAPVSAHYANTELAARWSEMWMPFLPSLAGE
ADDVLTRRWAEGARFMATADGTSLAAFEQPAREAAAGARAMLAMAAAERWDVPWEECRAE
NGFIVHENQRLSFGALAPGAASFDPPDPAPLLPVAPGEGAEEPAEGAPLRFPRVDLPSKV
DGSFQFAGDVRLPGMVYAAIRHGPAGRARLAGFEASRAAGTRGLLKLVKGTDWLAAVATS
WWAADQALARIAPEFTVSNAADSAEIEEALEKALRFGPAEWSHERGDPGAVLADEFDVAE
RYFAAPALHATLETASAAARFEDGRLELWIATQAPERARAAAAGALGIGVRDVVLYPMPA
GGSYDRRLEHDHAIEVALIAREAGRPVQLTWSRWQEHVRGWPRTPVSAVMAARTTASGDV
TGWKARLAMPATAREFGHRLFDGATASAAIADSAGKGDALAMEGAIPPYAIEHMAIEHVP
ATISLPTSRLRGNAHGYTAFFTETFVDELAHRAAREPLSYRMALLSDDLRLAECLQRVAG
LANWGGGVDNSGQGIACHRIGEGRIAAVATARRDQSGVRVDSISAVADIGRIVNRDIARQ
QIEGGIVFGLGLALGCSTTWERGIPATGRLAALNLPVLADCPRIDVAFVGSGAAPADPGE
LGVAIAAPALANALFSATGLRFRRLPLLSEEL
>U2XV87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MIMKVHDTNLSPPEDIDGGEPIICPAQADPAFLADLHKGGFTSAYEQHWNNKAMSEMLAM
PGVFVHQFSAGFIMTQISFETAEILTFTVLPGLRRKGYGVALLKAAMLHAFNKGATRMLL
EVAPDREAALGLYSRAGFKRIGVRKNYYAGPEGKRDAFLMEIGLGTEFNFR
>Q07GL2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter denitrificans (strain ATCC 33942 / OCh 114)|TrEMBL
MINFTLNGRSVEVDNPEDELLLLVIRDELGLKGTKYGCGAAMCGACTVHVDGEPEFSCQL
SVGDVAGYEVTTIEGLSEDASHPLQKAWIDQQVPQCGYCQSGQIMRAAALLSENPDPSRA
EIAEYMAPNLCRCGTYNRIFKAVEQAAQEV
>A0A482ZGR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MRCDLRIDLSRLHFQCRWCKANLCCDLRIDLSRLHLLCIASPSSSCCDLRIDLSRLHFPI
SSGSVHQSCDLRIDLSRLH
>A0A0P1GTD1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassobius mediterraneus|TrEMBL
MSDKKPQSRLRKYSRRAFLIGATAVAGGVAFGTYVVKRPHDNPLAADLQDGEATFNPYVK
ITGDRITLIASHTDKGQGVHHSQAALIAEELDVELDQVEISFGKPAPAYWNTGLANDAVP
FSAFDESFKARAARGAVSSLGKVMGLMVTGGSSTMPDQFEKLRSAGAVARETLKAAAAQQ
TGVPVTQLKTARGMVILPDGTELPYTDLAATAASMEPVTDVALRDPSQWRMIGKPMQRVD
VVAKSTGTLTYGIDLKVDGMVHAAAKVNPRQGGAMLSYDASAALEMPGVQKVLVLQGDML
DPELDGSLTRRRTKVGVAVIANNTWRAFQALEAIDIEWGSAPYPAEMDAHWQTLSDSFTE
DKLDSAWRTDGDVEAALDGAEVLEAEYRAPYVAHAPLEPISAIVRADKDSAEVWVGHQMQ
RFAQMKVAAILGLDDPEKVTLHNQFIGGSFGHRLEFENVTIATEIARQMPGVPVKLTFSR
EEDFAHDFPRQIAMARGRGAAKDGKVDALDMQIAMPSVVASQMSRVGQPVAGPDNQIVAG
AWNMPFDIPNLRVRGYRAPELAPISSWRSVGASSQGFFAEGFFDELCHAAGVDPLEERLR
LVNNPLHRKALEAVGEMSNWGSALGPNRGRGIAMVESFGVPTAEVIEVTATEDGIKIDKA
FVVAEVGRIVDPVNFENLMQGGVIWGLGHAMNCEITYSDGMAEQSNFDSHEGMRLYQCPD
IMVRGLENGDNIRGIGEPPVPPAAPALANAIFAATGTRLREMPFANFVDFV
>A0A7W5HMK5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas stenophila|TrEMBL
MTTLTINGQPHEVDAPDDMPLLWAIRDLVGYTGTKYGCGRGLCGACTVHLDGQPTRSCIT
PLSAVGQREITTIEAIAEDATGASVQQAWRELEVVQCGYCQSGQIMAATALLRDNPAPDD
AAIDGAMRGNLCRCATYVRIRAAIHAAAESLGQEET
>A0A447QVT0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MELNINNKIYQTDADADTPLLWVIRDDLAMTGTKYGCELAQCGACAVMVDGQAVRSCVTP
LETVAGKKITTIEAIESDDVGQRVVAAWVKHQVPQCGYCQSGQVMAATALLKHNAHPSDE
EIAAAMVNLCRCGTYNAISAAIHEVAGKGDKA
>G8AZ09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum baldaniorum|TrEMBL
MLNQLIKQAAADVAAPSRRGFLKGAGGALVLGAMLPRTGFASEAAAPKVVGPADPRPQAF
IRIAADDTVTVLVKHLDKGQGIMTGLTTIVAEELDADWAQMRGAFAPADGALYANHFFGI
QGTGGSTAVANSWDELRMAGAAARAMLVATAAARWSVPASPVTVEQGVVRHAASNRSARF
GELAEDAAKLPVPQNVALKDAKDYKLIGNPSLHRLDHVSKTDGTAIFAMDIRRPGQVTAV
LARSPRFGGTVKSVDAAAAKQVPGVLEVLTLPMGVAVVARNTWAAMKGREALTVEWDDAK
AEMRGTEEMLADYRKLADQPGNVATDTGDAAKALAGAAKVVEAEFVFPYLAHAPMEPLNA
TVELTPDGGCTIWAGSQFQGVEQKVAAGILGCKPEQVVINTVWAGGSFGRRATPDADYIA
EAVTIAKAYGGKAPVHLVWTREDDIRGGRYRPLFLHKVKAGLDASGTLVAWRQSIVGQSF
MIGTLFEGFMVKNGVDATSVEGSSDMAYTVPNLHVDLHSPPSPVTTLWWRSVGHTHTAYA
KEVMIDELAAAAGKDPVAFRLEMLKDHPRLQGVLKLAAEKAGWGQPLPKGKGRGIAVHES
FSSFVAHVAEVSVDEQGRVTIDRVVCAVDCGQVVNPNIVEAQVSGGTGWAIGHALRDEIT
LTGGLVDQSNFDAYQPLRNSEMPPIEVHILPSTARPTGVGEPGVPTAAPAVANAVFAATG
KRLHHLPFTRSGMV
>A0A840YW93|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stakelama sediminis|TrEMBL
MADTQTSGRGIDRRKLLIGGGAGVGLIVAYALWPRHYMPNLTAAPGETIFGAWLKIGKDG
EVTVAVPQAELGQGVYTALPQILADELGADWRTVGVEAAPLNALYANALAADILFRDAFA
NLPEGFRRSHAERTALMLTAASTSIRAFEPDLRQAGASARVLLCKAAAKRWKVDWRSCNT
AEGFVIHGNDRLRFADLAADAAHQSLPQEIPLRQETSNRLSGSSVQRLDTPAKVDGSANF
AADVRLPDMVFASVRQGPVGDTRLLSSNHAAAKKVRGVLSIVENANWVAVVAENWWAANK
GLDALAPRFETRGAIVDSDSIDAGLKAAIDGKGERMASVGNLEPVFRDAQIVAADYSVGL
ALHAAIEPMTATAHWTDGRLRLWVPTQAPGLARAAAAKAANVSEDAVIVYPMMAGGSFGA
KLETVAAAQAALLTRKFGRPVQLTWSRSEECLHDRYRPAALGRMSARLGPDGAIQGWLCK
IAAPPVGHEVAKRLLGGDVAAALSQAIPGTGIGDHAAVAGATPFYAIPNYALDHHPADIG
VPVGEWRSGAHSYSCFFTECFLDELAHVAGVEAHSFRISMLGGHPRLARCLTTVASLGAW
QGGIAGSGQGMACHMFRGSYIAVMAEAHVDEDQQIRVDRLVAAVDCGRMINPDLVRQQIE
GGLIFGVAGALGGSTGFTDNLADARGFADLNLPTLADSPEIQVEIIESGADPGGVGELAV
PPVAPAIANAIQSATGVRLRDLPLTVGDDS
>A0A7W9EHG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium boeckii|TrEMBL
MQPDTTVLTRRAFLSASLLAGGGLALDFTIPVQAAVPAGASVLGAFVSIAPNGAITIMGK
NPEIGQGIKTSLAMMIADELDADWAQVSVVQADVDPDRYGPQFAGASLSTPTNWLPMRRA
GAAARDMLLRAAATRWNVPIDQIKTAKGRLIHGATKRSLGYGDVASAAAMLTPPDLQTVK
LKSPDQFSIIGQPTRGVDSGRVIRGEPLFGIDTRLTGMLYAAYEAPPAHGAKLRSADLSA
AKAAPGVKHVFQIQGAGGPGGVVEGIAILATNWWYANEARAKLVLDWDMTAAKGHSSEDY
AAQAKALLDANAGIDFERSGDPAKAMAGAAKRIKSRYDYPFLAHATLEPQNCTALYQNGQ
IEIWAPSQQPQPGRELIAKELGIPLDKQIVHITRIGGGFGRRLNNDYMAQAAAIAKALPG
VPVQLLWSREDDTRRDFYRPGGWHEFEAGVDGDGKIVAFTNHFATFGADGKSQRFANMAE
RHFPARLVPNLAFTQSYMKIGIPMGALRAPTSNAMAFCFQGFLDEVAVLGGRDLPSLILE
LCAEDKIVGDADAPDIAPKGFHTARARAVVEKVVEISKWAERPKEKGRGRGFAFYFCHQG
YFAEVVDVSVADDKSITVHKIWAAGDVGRQIVNPMMAEAQVRGSILDGLAQALEGQKITF
TDGAIEQSNFSDFRLGRIDRNPDVEIAWVLSDFHPSGLGEPALPPVIPALTNAIYAATGT
RVRSLPIEL
>A0A833J9H4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MNDLIPLHRLGLGARPTREPVKNLSRRGFLGIASGALLLGIDLPGGAAAQTRAEGPAAVA
PKPGTRVAAFLEIRPDSSVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFAVECAPPGP
DYAVVNGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAARLAVAQDSLTTEDGRVIHA
ATDRTLGYGELAQAALALQPRDDVPLRDAKSFRWIGRPVARLDMRDKATGRATYAIDIRV
EGMLHAAVQHAPHLGTEPQVIANEAAVRAMPGIHSVHRLPGAVAVVADSWWRARKGAEAL
QVTWTAPAPEGIATVSQSFSSSAMLAALKGSTEPGIPAEQEGDPAAAFAGAAKVIEAEYD
APYLAHAQLEPPSAVARFTADGSLDLWLPNQMPELFQQIAAKTAGLEPEQVRIHSPMLGG
FFGRHFAYGPANPFPQAILLAQATGRPVRVLWSREEEFGMDAVRPLSFARFEAALGADGM
PVALQTVAVGEGPIGRWFGALFKSPVDSSVVEGLDKKPYAIPNRRLDYVKVPHPVTIAFW
RSVGHSMNDYFYESFLDEVAAAGDKDPFDLRMALLKDSPRHRTLLKAVADLAGGWRRGPF
AAEDGTSRARGVSMASPFGSETATIAEVSLKDGEARVHDLWIAIDPGSVVNPAIVKRQVE
SAAALGLSSTLLEQVVYENGQRQAKNFDAYPILDRERMPRVHVTIVESGAPMGGIGEPGL
PGVPPAVVNAVAALTGRRVRSLPLAKTPLSGV
>A0A0S4WH12|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MRIRNLEALAGGGAHDPAAPACADASVATLDRRSFLKLTALAGGGFALGVAPMLAGAQDA
AAKPPSPPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAG
DPYKDPLFGIQLTGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSACRTANGVVI
AGSRRATYGELAQAAMALPVPRQVALKNPSQFRIVGKPTPRLDARAKLDASLKFGIDTRL
PDMKVAVVARPPRFGGKVAKYDAAAAKAVKGVVDVVPIQTDRGGTGVAVIADGYWPAKQG
RDALQATWDDAGSRVSSAALMREYKTLADQPGTVAKAADVGAIQSAAKRIRADYEFPYLA
HAPMEPLNCTIDLQSAGGKVSGAKVWVGTQFQTVDQGALAKALGIAPEKVELNTMMAGGG
FGRRAVPTSDYLVEAANVAKAYAAAGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKGTPFESYMLKNGVDATMTEGVIENDYGFPMQVSVHHPDVDVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPAAYRLARFTDKEHERHRQALRLAVDKSGY
GKRKLPKGQAWGVAVHASFESVVAYVVEVSIDQGKPRVHRVTAGVHANRVINPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGAARNSNFPDFPPVRMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDTV
>A0A7W6HGF8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantimonas endophytica|TrEMBL
MARLLSRRTFLITGAALGGTVLVAGVAGAGFLASVDVDGPDGFVDGDRAVFNAFVAIHDD
GRVVIHVPRTEMGQGIHTGLAMLVAEELDLPFDERIAVEHPTQLLPVYASYSQIIGVRPE
EARGPVAWAVRRAVSAVPLIATGASGSTIGLWHPMRTAGAAARHMLVAAAAARLGVPASD
LTTADAAVHHAASGQSIPYADLARDAAILPPPREPALKPRTAWRLIGRSQPRVDLPPKVR
GEPVFGADVVLPDMLHATIRQAPVFGARVVRLRNEAEIRTEPGVRDVAVIDGRAVAVVAD
SWWQAEMAAWRLDVEWSGTEDDGVSSIALGDRLRAALDEAEHHLHLEDGDVEPALASETA
QLVEATYEVPFVTHACMEPMNATVLMRRDGTAEAWVPSQSPLMIRWGVQQGAEWAGLDPS
AIICHVTMNGGAFGRRGEQDVIAQAAYLAARHPDRAVKLMWPREEDIGRGMFRSHAAARM
QAALGPDGLPVAYDALVAAQSIIQSVGSRRLPITPGPDGDYLSIEGLEKAHYAVPSRRVR
SHHVPSHLPIGFWRSNGYSFGTFFSESFVDECALAVGLDPFDYRRVLLRDSPRHLAVLDR
VAALADWGAPMAPGRGRGIAIEECYQSVVAEVAEVTIAPDGEITVDRVFCAVDVGTVVNP
DAVAAQMEGGIVFGLTTALMSTLTVEAGAVVESNFHDFPMQRIRDVPEIVVDILPSDLPP
GGAGECGNVPIAAAVANAIHAATGRRLRSLPLAVTEATGERRTRSVLPQLTAGAA
>H0SCD6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MVDLNINGEIRSYDVPDDMPLLWVLRDVAGLVGTKFGCGIAQCGACTVHVDGRPARSCVM
SVSAVGNRQIRTIEAIGRDPVGQGVQKAWVDLDVVQCGYCQSGQIMSAVALLNVKREPSD
ADIDAAMAGNVCRCGTYPRIRAAIKTASKV
>A0A2C9D917|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hartmannibacter diazotrophicus|TrEMBL
MKIAHDFAPAEALALMKPDGVTNLSRRGFLGVSAGALLIGALLPAGQARAQASEAIKPGT
RIPAFLELRSDGTVRLLSPFVEGGQGIATGAAQIVGEELDVHPSRFAVECAPPGPDYAVI
NGLRMTGGSFSTRSSYMVFRQLGASLRDMLIRAAAARLDVPRAELDTDDGVVRHAASGRS
IVYADLVAEALKLEPASEVALRDPSTFRYIRQPMDRLDVRDKSTGKAVYAIDQKVEGMLY
AAVVHGEHFGTEPTAIANEAETLTMSGVHAVHRLPGAVAVTANSWFRARKAVEQLEVTWT
APKPTGLDTIAADFSSAGMLAALKASTDKGVPAETVGDADAAFASAARLIEADYDAPYLA
HGQLEPPSALARFNEDGTLELWISNQMPELFQMYAAKTADVPVEKVIVHSPMLGGFFGRH
FLYGSSSPFFQAILLAKETGKPVKVLWSREEEFKMDAARPLSFSRFSAALDKDGMPVAIK
VRTVGEGPIGRWFSSVFKDPVDSSAVEGIVAKPYAIPNRSMEYVKVVHPVTIAFWRSVGH
SMNDYFSESFFDEIAAAGDKDPYELRRVLLQDKPRHLHLLDVVATMSGGWKRGPYEVEGV
KRARGVSMASPFGSETATIAEVSIEDGSVRVHNLWIAFDPGSIVNPRIVQSQVESAAALG
LSATLHEELPYEGGVRQVSNYDTYTILSRDEMPKVHVEIVESGEPMGGVGEPGLPGVAPA
VVNAVAALTGQRIRSLPLAKATFGA
>Q0K113|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)|TrEMBL
MKLQLKINGKRHAVDADRDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGSVARADITTIEGLSADNSHPVQRAWIVEQVPQCGYCQSGMIMAACALLKENPEPAP
EDIRAGITNLCRCGTYPRVERAILRAARGQSMADTDGRAQS
>A0A2C9D004|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hartmannibacter diazotrophicus|TrEMBL
MIKLKINGTEREIDADEDTPLLWALRDEFDMTGTKFGCGVGLCGACTVHLDGVAVRGCQT
AIGDVGASEVTTIEGIAGKAAEAVKAAWVDLQVPQCGYCQSGQIMSATALLTDNPKPSDD
DIVTAMDGNACRCATYVRIHAAVKRASEMMEG
>S7XE55|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Winogradskyella psychrotolerans RS-3|TrEMBL
MKIAATTGGGLLIGFNWSACDSPKMKVISDQEIYDRAVNFNSFFIHFPIQSRGDFFHPIL
NWGKTSKPHFQ
>G7EF65|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas sp. BSi20652|TrEMBL
MNQDNKYFDLNRRKFLKTSAIGALVLGTYFVGSAPRAIAGVLEQPSELAKRANLFIALRP
DGMVEITCHRSEMGQQIRTAIAQIVADEMEAAWDKVIVIQGKGDPKYGDQNTDGSRSIRY
NMQRLREMGASVRYMMQHAAAKYWKVDPQTCTANQHVVTHSSGKSLTYKDLIDLALTITP
PEADKLTLKTRKEWRYINTGMAHIDLADLVTGKAIFAADVREPQALVAIIERPPVVGGVV
KSFDASATKAVNGVIDVIEIPAPKGAPQFQPKGGIAIIAKNTWAAWQGRKALKVVWDDGK
NGDYNSEEFKKSLLKTVQTPQANIRDKGDAMGVLAKSSNKLVADYYAPHLAQAPMEPPCA
TAMYNKDSVDIWAATQNPQADMKTVAAMLGMDESKINVHVTMLGGGFGRKSKPDFSAEAA
YLSMKVGKPIRVQWTREDDIQHGFYHAVSAQHIEASLDKNGAIESYLHRTAFSPITSTFS
EGATTPGSFELRLGFTDNPINTPNMKLENGDAQAKARIGWMRSVSNIFHAFAIQSFIGEA
AHKAGRDQKDYLLDTIGPSRIVDVTEQNATYDNYGGDKAVYPLDIGKLRHVIEKVADMSK
WGRELPKGRGLGIAAHRSFLTYVATVVEVEVSDAGDLKVIKSWVAIDAGTVVNTDTVKNQ
TQGGSIYGITTAISDGITFDKGRVQQSNFHDYRVPRMSDSPLEVEVEIVQSDAPPAGVGE
PSTPVYAPALCNAIFAACGKRIRQLPIGNQLKA
>A0A085F9T5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Devosia sp. LC5|TrEMBL
MYTISVNNQTYDVDEDGQTPLLWVLRDILKMTGTKYGCGIAQCGACTIHVDDQPMRSCTL
PLEVASSYRITTIEAVEGTEVEAVRAAWVARDVPQCGFCQSGQIMSAVALLRTIPSPSDS
DIDTAMSGNICRCATYNRIRAAIHDAAGTLKGAAE
>A0A7W6GFF9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hansschlegelia beijingensis|TrEMBL
MLTLNVNGEDRSVEVPEDMPLLWVLRDVIGLTGTKFGCGIAQCGACTVHVDGQAVRSCVL
PVGELGDAKITTVEAIGATPEGKKIQDAWLAVEVVQCGYCQTGQVMSAAALLRHNPQPTD
EDIDAAMSGNICRCGTYVRIRQAIHQAATGKPVAEQTIAYNLQKGPAQ
>A0A0P1H5K6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Leisingera aquaemixtae|TrEMBL
MSTTLRINGKSHQVDLPEDVPLLWVLRDEIGLTGTKFGCGVAACGACTVHIDGAAARSCQ
VALSDVWGEVTTIEGLGTPDAMAAIQQAWVEHQVAQCGYCQSGQIMQAASLLAENPAPSD
AEIDEAMQGNLCRCGTYPRIRAAIHAAAQKMQEA
>A0A375CB76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSHPHASRRRFLQAAGAVPAALVLGFHLPLAKAADASAPARDPDDINAWLRIDADGGVTI
MVPSAELGQGVMTSAPMLIAEELDCDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQGWGVPVAQCRAVQGVVRHEASGRALGYGALAARAATLPR
PSSVTLKDPRDWKLLGRPTDRLDIPLKTCGAAVFGVDVKVPRMLVGSVMACPAFGGRLRR
VDARPALALRGVRRVVPLDDAVVVLADSYWTARKGLAALRPDWQLPPGEPVGDAALMAGY
RDAARGASSVALRHGDAEAQMQGAQAYTAEYEVPYLAHATMEPMNATADVRADRAEIWGP
TQVCGEIAQRLSGVLGLPAERIVVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPDAAGIRALEARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHLSVRHAMVNTAVPVGFWRGVGYTQNAFFAESFIDELAHHAGADPLQFR
LRLLADRPRPARLLQRLAQHVGWGHAPAGRFHGVALSQAWGSLCATVVELSVQGQRITLH
RIVNAIDCGTVINPATVERQLEGASIWGLSAALSGAITIADGRVQQSNFHDYPLLRLAQT
PRFEAVLAPGGERIGGVGESAVPTLAPALANALFAATGQRIRSLPLARHGFELA
>A0A7Z7NP92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSPLYTSRRRFLQAAGAVPAALVLGFHLPLAKAADAAAPARDPDDVNAWLRIDADGSVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQEWGVPVPQCRAVQGVVRHEPSGRTLGYGALAAQAAALPR
PANVALKDPRDWTLLGRPTDRLDIPQKTRGAAMFGVDVKVPRMLVGSVTACPVFGGTLRQ
VDARPALAVRGVRRVVPLDDAVVVLADSYWTARKGLAALQPDWQLPQGQLAGDAALMAGY
REAARQASAVALRHGDPDAQMQGAPAFTAEYEVPYLAHATMEPMNATADVRADRAEVWGP
TQVCGEIAQRLSGVLGMPAARIAVHGTFVGGGFGRREEFDVFVQAALASRAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAADAPGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHLAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAGTDPLQFR
LGLLADRPRPARLLQRLARHIGWGSAPAGRCHGLALSQAWGSLCATAVELSVQGQRITLH
RIVNAIDCGVVINPATVERQLEGASIWGLSAALSGTITIADGRVQQSNFHDYPLLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGQRIRSLPLARHGFELA
>S2DK26|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)|TrEMBL
MAIKLKVNGVSLTIEADPEEPLLYILREEFGFNGAKFGCGLQQCGTCMVLADGEALATCV
QPCQNFEGMEIITIEGLSEGDKSHPLQETFYSEQAAQCGYCVNGMLIAALALLRKNPKPN
DEEIRLSLDKVICRCGTHSRFISAVKKAADQNSRF
>A0A3G7YFV4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R5-89-07|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVKGQAISTIDNLHTDPVGQVVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQAATHLGAKA
>A0A4P8HWB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MRKEWLNGSDMAAAAAGDQPGVSRRGFMKGAGAGLVLGFTFTGGGRMARAAEPKPAQQPN
AFLRIAPDNTVTVQVNRLEFGQGVQTALPMLIAEELDADWSQIRGALAPAGDAYKDPAMG
IQITGGSGSVAHSWVQYREIGAKARAMLVAAAAEQWKVPVNQVKASKGVLTAPGGKKATY
GQMAEAAMKQPVPEHVVLKNTEKFRFIGKPMPRLDARAKSNGSQQFGMDFKPAGTKVAVV
ARPPVFGAKVAKFDATAAKKIKGVLAVVPVEVDRGGTGVAVIAEGYWQAKQGRDALAIDW
DTDGVEKVSTEQQFTAFRTLAAKPGAVAKQADTSKLAAAPKKISAVYEFPYLAHAPMEPL
NCVVDLQRDACTIWAGSQFQTMDQAAAAKTAGLKPEQVTLHTMMAGGGFGRRAVPSSDYI
VEAVNVAKAWAKAGKSGPVKVIWSREDDIKGGYYRPSHVHRAELGLDARGNIVGWDHVIV
GQSIISGTAFEPFMVKNGVDATMVEGMGEPYRVPMHLSVHNAQANVPVLWWRSVGSTHTA
FVMETLIDEAAVAAGVDPVAYRRKLIPAEHKRHHLALDLAVGKSGYSTVKLPEGQAYGVA
VHESFGTVVAYVVTASVENGTPKLHKVTAAVHCNQAVNPLTIEAQVQGAVLMAVGTTLPG
AAITLKDGIVEQGQLSDYTVARMTDMPQVEVHIVPSTEPPTGMGEPGLPPLAPAFANAVF
RITGKRLRKLPFDLASAAAPQVA
>A0A1W6NWP3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ketogulonicigenium robustum|TrEMBL
MFELSINGQNVSVDVDDDTPLLWVIREELGMTGTKFGCGIGMCGACTVHIDGVARRSCVT
TVAQAAGVKITTIEGLSEDDSHPVQEAWRSLRVPQCGYCQSGQIMQAASLLAGNPNPTDQ
EIDQAMTGNLCRCMTYVRIRQAVREAVTAINEGAVQNG
>A0A4P6WB45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter sp. JH2|TrEMBL
MATEFELNGQPVTVDIENDTPLLWALRDELDLTGTKYGCGIGMCGACTVLVNGRAIRSCI
TPVKAVSGASITTIEGLHPEGNHPLQKAWIETQTPQCGYCQSGQIMQAAAMLQDFPEPTD
EQINQAMGGNLCRCMAYVRIRKAIKLAAAEIKEASSPTAQETGAAANE
>F2R5L7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)|TrEMBL
MPQHTFILNGKAVTADVEGDVRLLWVLRDVLGVTGPKYGCGVGVCRACTSHLNGKAITPC
AVPVEDLGPTDEVTTIEGLADTVGGELHPMQEAWLDLDVAQCGFCQPGQIMTAVAEVRRA
REAGREITEADLDTIRNICRCGTYHRIRQAVLEGARRME
>A0A1X7A192|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax jejudonensis|TrEMBL
MIEFTVNGTSQRIEAPAEMPLLWVLRDRLGLTGTKYGCGVGQCGACTVHVNGMAVRSCLR
PVGQLSGADITTIEGLGDAGAPHPVQAAWIDRQVAQCGYCQSGQIMQAVALLSVRPDPDD
AEIDAAMTGNLCRCGTYPRIRAAVRDAAQRLQEA
>A0A2P9AFJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium delmotii|TrEMBL
MNDMTPSRNHWSTGSEDGPLNISRRSFLGGAAALVLSVTVPVGSARAQAAASITPGARVS
AFLEIRPDSTVLFRSAFIEGGQGIFTAMAQIVGEELDVDPVNFTVEGAPPGPDYLLTGGG
RFTGGSMSVRMSYETMRKLGASARQMLLQAAAARLGLSISELSTEPGRVVHAASGRAIPY
GEIADAAADLSVPTDVVLRSRDDFRWIGKPVRRLDGREKSTGRAQYAIDLKVDGMLHAAV
QHSPRLGGEPGALTNEAEVQAMPGVHSIHRLPGAVAVVADSWWRARRAVEALQVTWTEPA
AATPRAMPADFSSETHKAMLKSTPGDGVAFEQEGDAAGTLAGAARIVEATYDAPYLVHGQ
LEPPSAIAHWNADGTLELWIPNQAPEMFQAEAAKVAGIEPGKVIIHSPMLGGFFGRHFLY
QTANPFPQAILLAKAAGRPVKLIWSREEEFLRDTLRPMGVARFRAGLDGDGLPVALDAVA
VGEGPTGRWFGRQPDKVDSSAVEGIAGKVYAIPNRRVGQVHVDDPAIIGFWRSVGHSMND
FFYETFFDEMADAGQQDPYELRLQLLADSPRHSNLLQAVADLSGGWKRGPFAAEDGSRRA
RGVAMASPFGSEVATIAEVSLRDGAVVVHDVWVAIDPGSIVNPAIIEAQVNSAVALGLSS
ALLEEVVYVDGMPQARNFDGYPILPPDRMPRVHVRIVESGAPMGGIGEPGLPGVPPAVVN
AASVLTGQRIRSLPLSKLDLKGMEG
>A0A2P9AQL6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium delmotii|TrEMBL
MRLTVDGQAFDVNADPEMPLLWALRDLMGKTGPKFGCGIAACGACTVHVDGQPVRSCSLP
VGEVTGAVTTIEGIGTEGRLHLVQQAWLEEQVAQCGYCQAGQIMSAVALLDEVADPTDAD
IDDAMGGNLCRCGTYPKIRAAIKRAVVLKTAGI
>A0A7W5MRN6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. BK369|TrEMBL
MTTPIATPSRRAFLAGSAVLASALVVPLHRALSSVPAAQLAANGYLAVLPDGAVSLALPK
TEMGQGIMTALTMLVAEELGLAPSAVKVSIPPADRARFAPVDTTTGGSTSIRELWKPLRQ
AAANARAALVDAAARQWKVMPDGLTLADGAVVNPASGKRLGFAALVADAAAHVPTDATPT
PRAAWKVIGKDTRRLDSADKVRGTAQFGIDVKVPGMKIATLAQSPVFGGKLAGHNAAAAK
AVPGVADVIALDDCLFVTADSLWTAKKGLEAAAPTWNEGANAGLDQAQVVAALDAAVAKP
GVTAKAEGDLAQARAGAAKTVEALYHQPFLAHATMEPGNCTAHVTPQGVQVWTGTQVPSD
CRAAAARMAGVAEDKVQVHNFLMGGGFGRRLETDMVERTVSLAAKVPYPVKLVWTREEDI
QHDMVRPAYADRISASLDQAGKVTAWEHRIAGSAVMARFLGDKFNGVDDDAVDGAIAPLY
PAKARLVTFKQVESAMPTGWWRGVGGLRNTFVIESFADELALAAGQDPLAWRLAQITDPR
ARAVLQKAAAEAGWGKALPKGEGLGLAVLHIWDTCLAAVAHVKVDAQKQIAVPQVTVAVD
CGPAINPLGVKAQIEGGVTFALSAALYGGVTLEKGRIAQSNYNDVRPLRMNEAPRVITHV
MPTDNAPGGMGEPPAAVIAPAVANALFAATGKRVRQVPLQAGFEAA
>A0A0P0RQM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caribensis MBA4|TrEMBL
MSTTLILNGKSTTLDADPNMPLLWAIREVAGLHGTKFGCGMAQCGACTVHLEGQPIRSCI
TPLAAVEGRHITTIEGLQGKPAKAVQAAWVKLQVPQCGYCQSGQIMSAAALLAQNAKPSD
ADIDAAMSGNICRCATYTRIRAAIHDAADAMGA
>A0A0P0RQW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caribensis MBA4|TrEMBL
MTTDIVDVQRPSRRTFLKGAGTAAALALTIGFEWAGTSRRAIAAQAPGATFAPNAFLRVG
ADDSVTVIAKHVEMGQGAYTGIATIVAEELDADWSRVRVESAPADAKRYANLAFGTIQGT
GGSSAMANSWTQLREAGATARVMLVTAAAQQWKVPASELRTERGVVYHDASGKHATYGSL
SSAAAALPVPENVTLKDPKNFRLIGSQAPRVDVPPKTDGTAQFTLDVTLPGMLVAVMQRP
PLFGATVRSFDASAAKAVPGVVNVVQVPRGVAVVAKSFWAAKQGRDALKVEWDETHAEKR
SSADIMAEYRKAAGQPGLPARTEGDASKAIQGAARKLSASYEFPYLAHAPMEPLDAVIKL
TANSCEIWAGDQFQTVDQANAARVAGLQPQQVSIHTLYAGGSFGRRANPGSDYIVEAVSI
AKALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAGLTRDGKLVGWQHRIVGQSIVAGT
PFAGLIKNGIDGTSVEGAANIAYAIPNISVELSTMQTGVPVLWWRVVGSSHTAFAVEAFI
DEAAHAAGKDPYTFRRDLLEHEPRMRGVLDLAAQKAGWSNAPLPAGKGRGIAVAEAFKTF
VAQVAEVSVDKDGKVKVDRVVCAVDCGTAINPDVIAAQIEGGIGFGLGAALYGAITLKDG
HVEQNNFDGYRVLRIDAMPKVEVHIVASTQAPTGIGEPGVAPVGPAVANAIFAATGKRVY
AMPFSTESLA
>A0A388RS12|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MMKIDHSVNGPAGFSRRNFLKAAGVGGALLLSVDLPMAVAKTLAAPGGSAPATFNAFVRI
DSSDVVTLVMPRVEMGQATYTALSMLLAEELEIDPTRVQLEHASANDKLYAPTPGGQQVT
GGSDSVRTAWLPMRRAGAAARMMLIDAAARAWKVEASTCTAKNGVVLHEASGRRATYGEL
ATRAAQLPVPTDIPLKKPEQFQIIGSGLKRLDGPAKVNGSAQFGIDVKLPGLRVTTVAAS
PVFGGRVKSVDTQAAMAVRGVRQVVRLDDVVAVVADHMGAARKGLAAAKVEWDDGPAAGY
STQAMIDELAKASEQDGAIARKEGDVAAVRKDAASKGHRTIEAIYQQPLLAHATMEPMNC
TVRLGPDGCEIWTGTQVPTRAQAAAAEVVGLPQEKVQVHNQLLGGGFGRRLEVDFITQAV
RIAREVKGPVKVVWSREEDMQHSAYRPYHYNRLSATLDAQGRPIAWQHRVTGSSIMARFA
PAAFKDNIDADATRDAAGPYAFPNVLIQYVRQEPKLPGFLTSWWRGVGHMQNAIPVESFI
DELARAAGQDTIAFRKPLLHKHPSAVRVLDALVEKSGWTRPLPKGRGRGVALTFAFHTYA
AQVVEVSVDADGNVKIERVVTVVDCGRVVSPGSVEAQVQGGTIFGLSAALFGNITIKDGR
VEQSNFHDYRVLRMNEIPAMETHILPSNEDPTGIGELATVLITPALLNAIHDATGKRIRR
LPMTRDDLKTT
>A0A090VB64|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algibacter lectus|TrEMBL
MAPSKKMTFSRRSFLKSSALASGGMIIGFNLFNACKPEAKLPVDLSALNYNDFNAFIKIS
EEGKVTIFSPNPEIGQGVKTSMPMIIAEELDVLWEDVYVVQAPLDTKNYTRQVAGGSQSI
RFGWEPLRQTGATAKQMLVNAAAARWGVDASECSAKNGVITNAKGDKLGYGDVVLEAAGL
EVPEDVTLKDPKDFTIIGQGKGNVDIDKIITGKPLYGLDYKEEGMLYATVLRPPAFGQIL
ESFDDSGARALPGVVDVITIGEKVRAYNDSGKNSWTMPMSGTDKVVVIGKTTWDAMKGKK
AIKAVWKTETALESSETHDKVLLDLLEGNKFNTRRQDGNVKQAFANADKVLERVYESPFL
PHNCMEPMNFFANVSPEKVRLVGPVQTPEAAAQVVADLLERDLEDVSIDMTRMGGGFGRR
LYGDFVYEAAEISNAIQKPIKLVSSREDDMTMGVYRPSSKYKISASIKNGKITGYHLKEA
SINGNMYGLIPNFFPAGAIENYQVDTANYKSNITTGAWRAPYTNFLASAEQSFFDELAEE
LGVDRVQMHMDLLDNVKNNPDANIEYSPERLQGVLQLAIEKSNWGKTEVGVFQGLSVYYC
HNTHVAEVADITMEDGVPSVKRVTCAVDCGIVVNPFGAMNQIKGGVLDGIGHAMYADFGF
VDGVPKSNNFDSYQMIRMGQTPQVDVYFIESDIDPTGLGEPTLPPIGAAVANAIYAATGN
RINKQPLINNLEPKEKVLG
>A0A060IDJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. IE4771|TrEMBL
MVTLNINGSHHEVDVDPETPILWVLRDTLGMTGTKFGCGAALCGACTVHLNGEAVRSCST
PLSAAEGMNITTIEKTTDGSDRVGAAVHAAWVKHDVAQCGYCQSGQIMSATAFLASLPAG
SQPTAAEIDAAMEGNICRCGTYVRIRAAIADAASTLV
>A0A840B4F5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus rigui|TrEMBL
MADTPTADMQPAAPAKRKGVKRRAFLIGGVAVVGAGLFGISIADSNAAKSAKALLESDGG
HIFATWLKIGEDDSITIYSPHTDIGQGSNTGLAQMLAEELDAAWDQVRVVSAPAEPAFAN
VGLGRAFLADMTGQPAIINGIPQSFLSFLARQMNLQMTGGSTALRFTGRVTFQNVGAATR
LALVETAAKRLAVPAAELTTQDSHVIHAKSGRALRYGELAAEAATLSLDNAPKLKDPSQY
RIMRQSMQRLDIPAKVDGSAQYGMDFSVPDMRVATIMAAPVRGGKLTSVDTAPALAVKGV
EKVIKLDDAVAVVAKGYWPAISGLRALTPQFSDGGNGGISTASIFKAHDDLMAKGEADSA
AGDGDVQAGLGAQPIEAKYQVPFLHHAMMEPFALTAHFKDGKLNIWGGMQDPLATKMMAV
EVSGLDADDVTFHPMMIGGSFGRRLPMYMEIVGQVTKLAMQLPYPVKLIWSREEEVAQGA
YRPQSSAALKASLTKEKRIKAYRNDYAQPESAESETVFPYALPAVSRRHFAHVSNQQTGA
WRSVNSTQQGFYNESFMDELAHAAGEDPVVFRRNHLKAGSRHLRVLDEVAARSGWGSPLP
AGTGRGVALVESFRTIVAHVIEASVGDDGMPKVHKVTTVVDAGSIVNPDAAMAQIEGGTI
MGLSSAIGEAITLENGAVQQSNLADYPLLKMAGAPLVMDIHFLNSGADMGGIGEPGVPPA
APALANALFAATGKRVRNLPILTQAKA
>A0A7Y7LPW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MIKFSINGKPRQFDVPGEMPLLWVLRDEAHLTGTKFGCGMALCGACTVHVDGEATRACVL
PVSAVAGKKVTTIEGVGATPAGKAAQAAWLKVEVVQCGYCQSGQIMSAAALLEKNQRPTD
AEIDDAMAGNICRCGTYSRIREAIKDAGHAMKGA
>A0A1S1HK95|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas haloaromaticamans|TrEMBL
MTITLNINGQARTIDADPEKPLLWALREDLGLRGTKFGCGAGLCGACTVHADGAAIRSCQ
TTIADAAAMKIVTIEAVATTDAGRRVTDAWIALDVPQCGYCQAGQIMSATALLAATPHPG
DEDIDGAMAGNLCRCSTYLRIRAAIRQAAGAGGAGA
>A0A5P9BGP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Vibrio sp. THAF190c|TrEMBL
MALTLNVNGVDVSVDATPDTPILWVIRDHLSMTGTKFGCGMSLCGACTVHLNGQAIRSCI
TPVQAAVGQKITTIEGVESPAAKVVQEAWDELQVPQCGYCQSGQVMSAVALLEQNPNPTD
DDIDAAMAGNVCRCATYVRIRNAIKQASTKLS
>A0A378TCZ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mycolicibacterium tokaiense|TrEMBL
MTTDLPASLVTNRLISTWLTIAGDGTVALRVGKVELGQGITTALTQIAAHELDVAPESVT
AGATNTASSPDEGLTAGSLSITFSGAAVRRVCAEARELFRRAAAKTAGLDVTAVRLSSGV
FVTADGTRIGSYAELAAAVDLDVEVGDESLPVEFAPATAKDLPRVDLPDKVFGRPRFLHD
LEFDGMLHARVVRPPRPGAHLEVIAAESVSMMPGVEKVVRDGDLLAVLARREGQATRAAE
ALSAAATWSPGIELPDGDELSRWLRSAPAETSQVRADGARHNGPVTVRGTFFRPFLAHAS
IGPGCAIAVLDRGRLFIWSYSQGVFTLGQAIAAAVGLDTADVVVQHVEGPGSYGHNSADD
VAMDAALLALQVPGRHVRVQWSRGDEFAWEPYGPAMVGDLAASVDESGIITDLSYQLWTN
GHTARPGYTPRHSLLADAHRDGADALPPSVDPPAARGHGSARNAEPYYDIARVDVTVHRL
LTMPIRTSSLRSLGSQLNTFALESVLDDLARETGRDPLELRLANLSDPRARDVLTTAAAQ
AGWGTPVPDGHGRGIAFCRYKNRSSYCAVVADVEATDRLRVRRLTIAVDVGRVVNADGVR
NQIEGGAIQATSWTLLEQVRFDRNGITSTDWEAYPIARFSDVPRVDVHVIDRPDQPSLGA
GEATQGPVTAAIGNALADALGIRVHTLPFTQENIVAAINTAAI
>A0A653RPI4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. 9I|TrEMBL
MKFDWIDRAAVARSAGAGLSRRGFLKAGAAATGGLVLGFTLPGANRFANAADAKVYAPNA
FLRIAPDNSVTVIVNRLEFGQGVHTSLPMLIAEELDADWSQMRGELAPAGDVYKDPAFGI
QITGGSGSIARGFTQYREIGARARAMLVAAAAEQWKVDPSKLTTSKGMVLGPNGLKASYG
SLADAAMKQPVPATVVLKDAKAFRYIGKPMRRIDARAKSSGHQQFGIDFKPENALTVVIA
RPPVFGAKVAKFDAAAARAVKGVVEVLEVELDRGARGVAVFATGYWPAKQGREALQAEWD
SSAVAKVDSARQLEEYRQLAKAPGGSVARAADVSKLASAAHKISAVYEFPYLAHAPMEPL
NCVVDLKDDACTIWAGTQFQTVDQQVAAGLLGFKPEQVTINTMMAGGGFGRRAVPASDWM
GDTVRIAKAWRAAGKSGPVKVVWSREDDIRGGYYRPAYVHRADIGLDAKGQIVAWDHKVV
GQSIMAGTLFEPMMVKNGVDGTTIEGMGEPYAVPMNLSVHGVTQNVPVLWWRSVGSTHTA
FVMETLIDEAAHAAKLDPVAYRKGLMGEKHARHRAALDLAVAKSGYGTRKLPKGRAWGVA
VHESFGTVVAYVVEASVVEGVPKLHRAVAGVHCNQPVNPLSIEAQVQGAALMGLGMTLPG
AAITLKDGVVEQQNFGDYVVARHHEMPQVEVHIVPSNEPPTGIGEPGLPPLAPAFANAVF
RLTGKRLRKLPFDLATA
>A0A6J5H1X1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MLKRRTFLLGGAGAVGALLVGWGVLPPRQRLNTSTPLPTQGSQVALNGWVKIAADNTVTI
MMSKAEMGQGVHTGLAMLLAEELDADWSRVRVEEAPIDKIYNSVQNIIDDLPFRPDDDSA
FKRTTIWFARKAVREAGTMMTGGSSSINDLWTPMREAGASARMMLIGAAAEQWKVPAAEC
RTENGYVLHGPGHKASFGELSSMATLQAFPRKVELKNPADFKLIGQPIRRIEAASKINGA
ARFGIDALPDGLLYAGVVMCPTLGGSVAHFDETAARKMPGFIKALAFAPYSGGSGGVAVI
ADNPYRAMNAVEKIDVSWHDGAAATVSSADVDRRLAQALDDSNGHTYFHRGDVDAALSGA
ARVIDAEYHAPYLAHGAVEPVNCTAQVADGAATVWVSTQMPALARQHVAKVLDIDADKVD
LQTQLLGGAFGRRLEFDFIVQAAVIAREGGGHPVQTIWSRAQDFTHDFYRPACVSRLKAG
LDEHGKVLAWRSTSASQAIVPESLARYYGVPRIPIDKTTCEGAFDQPYEWPAARVAHKIV
ELPVPVGFWRSVGHSHQAFFTESFTDELAAAAGQDAIAFRAALLAEHPRHLAVLKRVAEL
SEWGQPMKPAADGAPCARGVALHEAFGSVVAQVAEVSLGPKRQIRVHRVVCVIDCGLPVN
PNLICQQMESGIVFGLSAALQDEVSIVKGQVQQKNFVDFPVVRMNDCPVIKTDIMPSRMH
PQGVGEPAVPPIAPALANAVFMLTGTRLRTLPLRLEKLPVTASNPQGCKVAPRQQASKGA
LNINGRAVAVHAEPDMPLLWALRCELGMTGTKFGCGVGICGACTIHLDGAACLACQTTMS
CVGYTQKITTIEGVQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKRIPNPTDADI
DAAMSNIVCRCGTYPRVRAAIHQAAAKRRQA
>A0A7W7L8U5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces netropsis|TrEMBL
MAEPSRRGFLTYLVAAPTLAVATGFGAAGAATAVAETVAGAPVPSLPAPADIVDLGDVLI
LAGVPTAHMLVLTVGENGRVSFRLPREEVGQGLTTAVAMLIAEELDVAVDRIDIRLEDAR
PELLFGQFTGSSNSIRSLYGPVRHTAAAARARLVRAAAKRWGLAASALRTRDGAVVAPDG
RSAPYGSLAVEAAARDLGAVTAAPKPESAHTLVGTPTSRIDARAMVTGRQRYTLDLDVPG
AKPCMVRRPPTLGGTVTSVRNEAAVRAMPGVLDVVTIPTGVAVVAETFGQALDAKNKLDV
AWGPGTVDGLSDDDIRARLKAAAEPWVDLPPLTRHIDAEFDFAFASHAPLETNSAVADVT
ADRATIWSGLKGPIVAQQTIAKELGLPVDKVTVHVVQAGGSFGRRLFFDAALEAARVSKR
SGRPVRLMWSRVDDTRHGRMRPATHHRIRATYALGKVLSFDHRVAAVETDFRHGLGEILT
ATVTKLPGGLGNATFAQTLFHTTVKCPYHFGVTTQHLTEVPLKMPTASWRSVYSANTRGA
EEILVDELAAKLGRDPVDFRRACLKNPAQRAVLDKVAREGEWGRPMPAGHAQGVGFHEEY
KSRTACLVEIDASDPKKPRVTKAVIAADVGRPINPRGLEAQLLGGLTDAISTTLRAGLHI
DKGLPLEGSYSQFHYARQKDSPPDVRIFIMPATGEPGGAGELGVPAAVGAIANAYARATG
TSPRRFPVNFDIDFTPFPR
>B1ZH18|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)|TrEMBL
MNAPTLSRRSLLLQGGALVVGFSLTGRDALAQQVFAPVATNGFSKPVAPDQVDSFLALGA
DGRATIFSGKVDLGTGIKTALAQMAAEELDLPLDRVSVVQGDTALTPDQGPTYGSLSIQK
GGVEIRQAAATARARLVRLAGEQLGLPAEALVSENGTVRPKAGGPGVTYGELVKAGRFDL
KVDPAVTTKDPATFALVGKSVARIDIPEKITGRFTYMQDYRVPGMVHARVVRPPAIGAEL
QSVDEASVADIPGLIRVVRQGNFLAVVAEKEWAAVKAAGQIKATWSRWEGLPEQDKLWQH
VRATRVTKDDVTSSTGDAAAALGQAARVLEASYDFAIHTHGSIGPSCAIAEFKDGLLTCW
TASQMTHALRKQLAAMTGLRPEAVRCIYIEGSGCYGRNGHEDAAGDAALLARAVGRPVRV
QWSRADEHGWDPKGPPTLIDLKAGLDGDGNVAAWSSQFHVPEGAAGNVPLVAADLAGLPH
ETTMSPGNIIQNSALPYAFPNVRTVCHRLATTPFRPSWIRTPGRMQNTYANEAFLDECAA
AAGADPLEYRLRALKDPRGIEVLKRVADIAKWQVRPSPRNEASGDVLRGRGLSYVKYELN
RTYVAGVAEVEVDRRSGQVRVPRFFVVQDCGQIINPDGVRNQLDGNVIQTVSRVLLEEVT
FDRGAVTSLDWVSYPILTFPDVPEVVIDLIDRPTEKPWGAGEPSAAIVPAAISNAIFDAT
GVRLRSVPFTPAKVKAALQAT
>A0A4P7NX08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hydrogenovibrio crunogenus|TrEMBL
MKHSLVVNDKNYSVEADSDTPLLWVLRDHLQLNGTKFGCGEGLCGACTVLIDGNPVRSCS
YPISSLKDQSVITIEGVDPEHPVVQAWKEIDVPQCGYCQSGQILSAVDLLDKTSNPTDED
VQSAMRNICRCGTYPEIKKAVELSTELKRKEA
>A0A7Y9IXR9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pigmentiphaga litoralis|TrEMBL
MDIKNVSRRRFIVGAGAFSVGVAFGPLTSLNDAQAADAATAAAASGGFRPVAWVSISPDN
IATIYSPASEMGQGTMTAIPMIFAEEMNLDWSRVRVEQAPTDAKRFGNPAFGGGLVTGSS
RTIKGYYESLRLAGLQARLVMIDAAAQAWKVPASEIRAEKSTLVHTPTGRRVTYGEIAAT
AQAPAALPKVDKTMLKPMSEFTIIGTDPMRVEVASKADGTAVYGLDIRRPGMVWAAIRYA
PVQGEKPVKVDDTAARAVKGVKQVVTLPQAVAVVADSFATARKARDLLDVTWTTTSQARS
YDSDVVLKEYVKRAENLDDAGTVWHKSGDVAAAQSGVARTFKATYTSDHVAQFTMEPMNC
TALVTGDMIELWVPSQVPSVVIGTVAAAAGFKPENIKVNITLLGGGYGRRAEADYTVEAA
QLAKTMPGVPVQMIWTREDDFQRSKPRPLTAHHVVAGVDANGKLQSLRHRTVSESIYART
SPAIFKAAGGKDSPVMEGAEGVYGIPSTLIEHVRDERGVDVSYWRGVGAGYQKFVTETLV
DEIAAETKQDPLKIRMDLTQGSPRAQAVLRTATDMAGWGTPRANGRALGMAFSDAWNTFI
AMVVEVSMKDGKPVVHQMWAAVDCGHAIMPRNVRAQVEGAAIFGLSAALGETLSYKAGQV
QQSNLTDYPILRADATPLVEIKVLPTDNPPGGIGEVGLPPVAPAVANAMARLTGKRVRSL
PFPQVA
>A0A1Q9R565|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MDLRINQQTYQVDADADTPLLWVLRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAVEADDVGKRVVEAWVKHQVAQCGYCQSGQVMAATALLKHNARPNDG
EIEAAMVNLCRCGTYNAIRSAVHEVANNEGAA
>A0A6J5AB98|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sediminicola|TrEMBL
MLKRRTFLLGGAGALGVLLVGWSVLPPGQRLTPSTPLPAEGNQVALNGWVKIAADNTVTI
VVCKAEMGQGIHTGLAMLLAEELDADWSQVRVENSPIDKIYNSVQNIVDDLPFRPDDDSI
VKRATVWMTRKLVRDAGTMMTGGSSSMNDLWTPMREAGASARAMLIGAAAAQWKVAPGEC
WTENGYVLHAAGHKASFGELSAMAAQQPLPRKVALKDPAEFKLIGKPMRRIEAASKINGT
ARFGIDALPDGLIYASVVMCPTLGGTVAHFDASPARTMPGFIKAFSLRPYAGGSGGVAVI
ADNPFRAMNAVSAINVVWNDGAAANLSSANVDTQLAQALDDSDGHAYFHRGDVDAALSGA
ARTISAEYHAPYLAHGAVEPVNCTVQVADGAATVWVSTQMPALARQHVAKVLDIDADKVD
VQTQLLGGAFGRRLELDFIAQAAAIAREGGGRPVQTIWSRAQDFTHDFYRPACVSRLKAG
LDKDGKLVAWHATSASQAIVPESLARYYGVPRIPLDKTTCEGAFDQPYEWPTARVAHKIV
ELPIPIGFWRSVGHSHQAFFTEGFTDELAVAAGQDPIAFRAALLAQHPRHLAVLKRVAVL
SDWGHPMTRAADGTKRARGVALHEAFGSVVAQVAEVSVGANKQIRVHRVVCVIDCGLPVN
PNLIRQQMEGGIVFGLSTALQDEITIVGGQVAQKNFVDFPVVRMNDCPVIEVDIMPSQMH
PQGVGEPGVPPVAPAVANAVFALTGQRLRALPLRVA
>A0A6J5AB13|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sediminicola|TrEMBL
MGSLNINGRAVAVQAEPDMPLLWVLRCDLGMTGTKFGCGVGICGACTIHLDGKAGLACQT
PMSSLHSQKIVTIEGVQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKQKPNPTDA
DIDAAMSNIVCRCGTYPRVRAAIHQAAAKRRPV
>A5EGS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MNALLKIDLSAVMPLIPDRGVTNLSRRRLLGLGAGAFVLGTLLPAFGARAQAAAAVKPGT
RVPAFLVIGQDNTVKLLSPFVEGGQGINTGLAQIVGEELDVHPSRFEVECAPPGPDYAIL
NGLRLTGGSFSTRSSYEVMRRLGASARDMLIRAAAAKLSVTADTLTTDDGYVVHAGSNRR
VTYGELAEQALALTPAENVALRDPATFRYIRQPMARLDVRAKSTGKAVYAIDQKLDGMLY
AAIQHAPVLGTEPERVSNESAVAAMPGVHAVHRLPGAVAVTADSWYRARKAVETLEVTWS
KAPATGFDAVAADYSSTGILAALKASDASGLSAEKDGDVAAAFANAAKIVEAEYDAPYLA
HGQLEPPSSMARFNADGTLELFVPNQMPELFQSIAAKVGDVAPDRVILHSPMLGGFFGRH
FAYGSSNPFQQAILLAKATKRPVKVLWSREEEFKMDALRPLSFSRFKAALDKDGIPIAIK
VRTVGEGPIGRWFGVTAGGKVDSSAVEGLVEKPYAIANRSMEYVKFAHPVTIAFWRSVGH
SMNDYFYEGFLDEIADAGGKDPYQLRLALLENKPRHLKLLETVARMSGGWKRGPYEAEGG
KRARGVALASPFGSETATIAEVSLQKGEVRVHNLWIAFDPGSIVNPAIITSQVESAAALG
LSAALFEELVYKDGRRQQHNFDDYPILSRSAMPSVHVEIVESGAPMGGVGEPGLPGIAPA
VVNAVAALTGRHVRSLPLAKAKLGV
>A0A7W5ZQ19|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella defluvii|TrEMBL
MSNKLNRRDFIKASTMMGGGILLSFRGNDSVAATLPAEVSFNSYLSISPDNFITIFAPNP
EVGQNIKTAFPMIVAEELDADWKNVKIVQAHLDTKKFNRQATAGSGAMQHSWDRLRKAGA
TARWMLMEAAAKRWNVAHHTLTTDNGWVWHKESGRKLNYGELATEAAALPVPTEVKFKEK
KDYKLVGKPIHNVDNADIITGKPIYGLDIYREGMLLAMIERPPFGTKIKSVETAAAKAMP
GVVEVIVFKNKVAVLGKSTWQVMNARKALKVTYEPEEAVESTADHDRIMKQLLEKSDVKP
SRKEGDVEAVLKTAPQIITREYQAPFLSHACMEPMNFFAHVKQDGVELIGPAQLPEDTRK
NVAKLLGVDIEKVTLEMTRMGGGFGRRQRSDYSMEAAELSSLVKAPVKLMWTREDDMRGG
QYRPAMRYRFEAALDAKGNWIGYRMRGVGVNSGNSTRPDHFPAGAVPNFQVDSIDHKSPV
TTSPWRAPSENFLGFAEQSFFDEIATAAHRDPIEYRLEYLEKAQKEPVGAVKYDIERMKG
VIKLVAEKANWGKKKNVYQGFSAYFSHGSYIAQVAEIEKVKGRIVLRKMIAAVDCGVVVN
LSGAYQQVQGGIIDGLGHALYGEVTLKDGIPNQQNFNTYRLIRINEIPAVEVHFMDSAIN
PTGLGEPALPPAAAAFANAFFKATGKRLYNQPFMKEEAMKGVKFGQSS
>A0A7W6EQL8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella defluvii|TrEMBL
MSTNQSRRDFFKTTAAAGGGLVLGFSWFSSEAFQPQVVGTAAADAIDFNAYLAISPSGTV
TIFSPNPEIGQGIKTAFPIIVAEELDADWEKVKVEQSPLDTKKFERQLTGGSGAIRHSWE
RLRKAGATARALLIEAAAQQWGVPASECSAQKGMVIHSSGKKIAYGDLAVAASKLPVPKE
VKLKATSSFSLIGSRVKGVDNKDILTGKNLFGIDYKRPGMLHAQVQRPPAFGLKLKSFDA
TEAKKMPGIVNVVSFGNKVAIVGKTNWEVMQARKAVKIEWEKEKDLESSADHDRLFKEML
NGTNVTVQRKDGDVEAAFKNAHKVIEAEYQCPFLPHSPMEPMNFFAHFKGDSIELAGPSQ
TPEAAQKQIAKMLNIAPEKVTLELTRMGGGFGRRLNTDYAVEAAELSSIIKAPVKVTWTR
EDDMTGGIYRPAVRYRFKASIDKAGNMTAFMLHGAGLNAGNSTRQDNFPAGAVENLLIQS
SDYKSPITTGPWRAPITNFLAYAEQAFLDEVAAAAGKDPVQFRLELLDKAEKSPVGKITY
ETKRFREVIKLAAEKSGWGKKKKGVSQGFSVYFSHASYVAQVAEMTMAKGKPVLKKVYAA
VDCGIVINESSAKNQIYGAIVDGIGHAMYGNLTFKDGAPQQENFNKYRLIRYNEVPDIEA
HFVNNGIEPTGLGEPALPPTGGALANAIFKTTGKRLYNQPFADQDGPLG
>A0A7X0PCZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MSAAATPPLSMDRRSLLRAAVGGLVLAVSGSGEVWAQGAKKYGAESMPGATVDAPLVFVS
IAADGLVTIVAHRAEMGTGVRTSLPMVVADEMEALWEQVRVVQADADEARYGNQNVDGSR
SVRHFLMPMRRVGAAMRQMLETAAAARWAVPVGEVRAEQHRVLHVPTGRSLGYGELSAAA
AAVPVPQGSALRLKAPAQFRYIGKGRVRAVDLADIGQGKAVYGMDVRLPGMVYAVVARPP
VLGGTLRQAQRDKALAVPGVLRLVELPALKGAPNFQPLGGIAVVGCTTWAAMQGRMALAA
EWDDGPHAGYDSAEYRKQLESLVRAPAKALRSDGDAAAALQAAPANRKLAAEYYLPHLAH
ASMEPPVATAVVHPGRCEVWASIQNPQAGVASVAGVLGIKPEQVQLHVMLLGGGFGRKSK
PDYVAEAVLVAREMPGTPVKLVWTRDDDIRHDYFHTVSVERLEAATDARGMPQAWLHRSA
APSITTLFGGKGPAAFEMGMSAINVPFAIPHVRIEGAEVDAHTRIGWFRSVSNIPHAFAV
QSFIDELAHRAGTDPRRFALDLIGPRRKILPTALSDSFNYSESPEVYPVDMGRMRDVLEA
ATQGAGWGRKLPPGQGLGLAFAYSFLSYTAAVVHVAVDDKGAVTVHAVDIAIDCGPQVNP
ERIRAQLEGGVVMGLGLALVGEITFAQGRAVQSNFHDYEVLRHHASPRVIRTHLVNDDHG
VPAGGVGEPPVPPIAPALCNAIFAATGKRIRALPIRSVA
>F7Q4D0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salinisphaera shabanensis E1L3A|TrEMBL
MSAASETALDQGSVAQRMSDIREAARGVSEGFSRQYMRECIDNHRFPQEAWDALGDYGLL
GITIPEALGGVGGGQVELVALMEALSETGMVLPMLLLTGFARVPILRNGTPDQIDRFVKP
TISGAEKLCFAITEPDAGTNSFAMTSLATQAGDGYRLTGRKVFISGAADADRMLVVARTQ
KASEVERRTEGMSLFVVDTDAPGVELQPLNIDVGWPERQYLVFFDDVELDADRLIGQPGQ
GLAAMFEALNSERLLVTAMSVGLGNYALKKAVAYANERKPFGKPIGSYQAVQHRLAEAKA
ELEAARLMMIQAAATFDAGGKAGDHANMAKLLGSRAAVKAVEAALQTHGGYGFDKDYDVI
TLWPSARLMEVAPVNNEMLLNYIGEHVLGLPKSY
>A0A7X5V9F6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kribbella shirazensis|TrEMBL
MPTHSFKLNGKQISVEAEDNVRLLWVLRDLLGVTGPKYGCGIQVCRSCTSHINGKAFNPC
SVPVKDLDPTDEVTTIEGLPATVGQDLHPMQEAWLKYDVSQCGYCQPGQIMAAVAKVRQA
KAEGRDLTDADLDELRNICRCGTYSRIREAVKAGAEDMGA
>A0A3B0T5M9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MPTYTLKINGNSRSVEVSADTPLLWVLRDHLDMVGTKYGCGIGQCGSCAVHIDGIATRSC
LLQVSQLNGQEITTIEGLSEDGLHPVQKAWKEVDVPQCGYCQAGQIMTASAFLDKNPNPS
EEEIKNAMHGNICRCAAYNRIQKAVAIAAENKMA
>A0A3B0RHW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MGDTNFIFTVNAEEVICSLPAATPLLYYLRNDLGLNGPKFGCGLGQCGACTILVDGVATR
SCITGVEDVKGSKVT
>A0A840ZQQ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodinum|TrEMBL
MAAMIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHIGGTAARA
CITPVSGAEGQEIVTIEGLSPDGNHPVQSAWRDLNVAQCGYCQTGQIMQAAALLKDTPKP
TDQQIDETMSGNICRCGTYPRIRAAIHQAAGNAPANKGERL
>A0A3B0T407|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MKIEFYVNGVPQAIEISDVNMPLLWVIRDTLDLKGTKFGCGKGACGSCTVHVNGKAVRSC
LYTAKFAEGKKITTIEGLGNEENPHPVQQAWVDEIVPQCGYCQPGFMMATAALLEKIPNP
TDEDIDTHINNVCRCATYYRMRKAIHRAAEIKNSASNQINVENDA
>A0A7W5WVV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK481|TrEMBL
MTRFTVNNQAIEYRLDPATPLLWALRDASNLTGTKYGCGTGHCGACTVDIDGRAVRSCRV
PIGSIEGRYVTTIEGLSHERNHPLQLAFIAEAVPQCGFCIPGMIMAAAALLKRDANPSEA
VIREQITNLCRCGVYPRVVEAIQRAGRATRGEEVLPAGPRPGIDPADSARLVPAFVPPPA
R
>A0A841MUU4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MATLNLKINGKTHTVDVEEDTPLLWVLRDHLGLVGTKYSCGIAQCGACTVHLNGEAIFSC
SMPVSSVGSDEVTTIEGLSEEGDHPVQQAWEEIDVAQCGYCQAGQIMNAAAFLKKNPSPS
MDEIENAMNRNLCRCGTYHKIREAVAKAAKI
>A0A6J5AZP4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia phenoliruptrix|TrEMBL
MSQGLLDAHKGAKRPQADANETRGLSRRTFLKFGVSVGAAAGGGLLLGFSLPAISQDQKT
GKSVIGGDANEVPQNGVFAPNAFIQIDTAGKVTLVVPKVEMGQGVYTSIPMLIAEELEVP
LDTVTLDHAPPDEKLFTDPLLGGQLTGGSTSIRYAWEPMRRAGATARTLLVAAAAQQWQV
DAASCHAQNGQVIHAASNRSIGYGQLVEAAAKLPAPQNVPLKDPKDFRIVGTAVKRLDSP
EKVDGTAQFGLDVRVPDMVYAAIANCPVFGGTLASVDDTHAKTIPGVRQVVKIDNAVAVI
GDHTWAAKRGLQALEIKWNEGAGAKLSMKQIVDDLAHASERNGAVARKGGNVVQGFANAK
TRVDAIYQQPFLAHATMEPINCTVHVRADSCEVWLGTQVPTRVRDAAMAATGLPADKIVV
HNHLIGGGFGRRLEFDMVTQAVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLD
ANGKPLAWQHRIVGSSILARFAPPAFKNGLDPDAVEVASDLPYDLPNQLVDYVRQEPHAI
PTAFWRGVGPTRSTFVVESFIDELAAEAKVDPVKYRRDLLGKTPRALNVLNTAAQAANWG
SAVPKGQGRGVSVMHAFGSYFAIIVDVAVDQGEVAVKRVVCAVDCGMVVNPNTVEAQVQG
GIIFGITGALYSEITIKDGRVQQNNFTDYRMLRIDQTPLIDVHIVKSSEAPGGIGEPGTA
ALAPALTNAIFAATGKRLRHLPVGSQLQTA
>A0A1Y5TN96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseisalinus antarcticus|TrEMBL
MRITVNGTSHEVDVEPDMPLLWVLRDELGLTGTKYGCGIAQCGACTVHVDGLAVRACQHP
IGTLDGARITTIEGLGEEDSVHPVQRAWIETQVAQCGYCQSGQIMQAISLLEGDPNPSDE
TIDRLMSGNLCRCGTYPRIRAAVRLAASRMGA
>A0A7W5ASC6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes campanulatus|TrEMBL
MPEHTFRVNGEQVTVDVDSDVRLLWVLRDILGVTGPKYGCGINVCKACTSHLNGRAFNPC
AVPVRDLGPGDEVTTIEGLAATAGADLHPMQQAWLDHDVVQCGYCQPGQIMAAVDLVRRV
AAEGREITDADLDGIRNICRCGTYARIREAIRAAAAAGG
>J4JMP3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CF2|TrEMBL
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCV
MPAVAVQGRKVTTIEGLSPDGRHPLQLAWVAEDVPQCGYCQPGQLMQAAALLNGGRLVDD
AAIVSAMSGNVCRCGTYARIHRAIKRAASGNPALDAVTGDAKEA
>A0A7W9IN31|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptosporangium becharense|TrEMBL
MPEHTFRVNGEQVTVDVADDVRLLWVLRDILGITGPKYGCGINVCKACTSHINGKAVNPC
AIPVRDLQPTDEVTTIEGLPATVGKDLHPMQQAWLDHDVAQCGYCQPGQIMAAVALARRA
AAEGREITDADLDGLRNICRCGTYFRIREAIRAGAENM
>A0A2N7RPE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. AD80|TrEMBL
MAGEKNTSRRRFLLGGLGLGVAGVGALVLGWGVLPPRQRLNGSAPLPVTDGAVALNGWLA
IATDGTVTLAMPRSEMGQGVHTALPMLVAEELDVALSKVKLIQAPMDKIFGNVAMLADGL
PFHPDDRGRVKALAQWTVAKAARELGVIVTGGSSSVKDGWGPMREAGASARAMLVGAAAA
LWQLPAAQCRTENGEVLHPDGRRASYGSLAQRAAAIDPGTPVLKAPKDFKLIGQPAPRRD
TPSKVNGSARFGIDARPPGMLYAALHLPPRLGDTLAAFDAAPVLAMPGVKKVIDLTPRLA
QRSVSCAAVVADTWWRAKQAAAALPTQWRAGPQSNLSSAGVYAEFARLLDSEAGYAYHAS
GEVESKDVQGLRQVSAEYRAPFLAHAAMEPVNCTAQVKNGKVMLWVSTQAPGIAVDVAAK
VAGVDAKDVVIEVLLLGGGFGRRLEVDMIAQAVAIALQCDGAPVQLVWTREQDTQHDMYR
PAALARFSARLDAQGGIASWDNKSVSGSITHQFLQRNFGLPGAGPDKTTAEGEFDMPYEI
ANQRIAHVIADSAVPIGYWRSVGHSHNAFFKESFIDELAHAAGRDGVAFRRGMLARHPRH
LAVLDAAVARAGSAPPGHAHGVALHQSFGSIVAQVAQVAVENGEIRVRRVVCAIDCGIAV
NPNIIAQQMESAVLFGLSAALGGEITFKEGKALQGNFHDYPVLRMGQEPLVETIIIASAE
HPEGVGEPGTPPIAPAVANAVFILTGKRLRSLPLRLG
>A0A1D8AY47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lacunisphaera limnophila|TrEMBL
MKPQTNPGVAVYGRRDFLRVTALAGGGFAIGFVLPGTVLAQATNMLDGTATQFTPNPFIR
ITPENIITILAKNPETGQGVKTHLPMIVADELDVDFNTIVVEQAGLRGDVGAQFAGGSRS
TPDNYQRLRVAGATARVMLIEAAAQTWGVPADQLTTEKGRVIHSASGRSATYGELATKAA
TLPIPDEKTVRLKKEGEFRIMGSRVGGVDNPAIVTGKPLFGIDQQLPGMVYAAYEKCPVY
GGKVISANTERIKKLPGVLDCFVLEGTDNINGLKPGVAIIATSTWAAFSAKKLLNVEWDE
SAGVGHGSEAYAAKAAEFGATEGKPVRNDGDAAATIAAAPYQAAGAYYYPFLNHATLEPQ
GCTAWAKDDGIEFWTTSQTPGGGQELVANTVKIPKEKLKLNFVRGGGGFGRRLANDYMAE
VAAIALRTNGAPVKLTWTREDDMRQDCYHRPGGWHFFKGAVDASGKLVAWHNHFVTFGFK
NTERTASGADLGFDELPARFVPNYRLEQTIMLTMIPTGPMRAPRSNGFCFAIQGFIDELS
HAAGRDPVQFRLDLLGEDRVVPPSEGQRGAPYNTGRMKGVIRLAAEKSGWGTPLPKGEGR
GVAFHFSHSGYVAMVAHVAVTPEGTLTVKEVTCASDVGPIINLSGAENQVEGSVMDGLGA
FWLQEMTFDEGRAVQSNFHDFPLLRINAAPKVGVHFIQSANPPTGLGEPPYPVVMPAVAN
ALFAATGKRIRVWPLNKTDLSGA
>A0A375H0S9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus neocaledonicus|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDNGEVLAFNGHVDLGTGIRTALAQIVAEELDVSLDNVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAARQLGVDVAALAADNGVFRVRGTQADIGYAALV
AGEHVELPLAEDVPVKPVESYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGACVGNSLLAVDRDSVRDVPGLVGVVVQGDFIGVVAEREEYAVQAARRLRVQW
KPVPPLPALDDPEPALRANPATRRELLTEGELPASGAGAVLQRRYVWPYQMHGSIGPSCA
VADWHDEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDERAADLLRAVADASGWRRGTAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIDVVLMPRQSEPPLGAGESA
SLPGAPALANALFDALGVRLRRPPFVPETVLAAMAAMSANKG
>A0A2S6RTC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alphaproteobacteria bacterium MarineAlpha9_Bin6|TrEMBL
MITLTVNGQSHTVDVDPDTPLLWVLRDTLGLTGTKYGCGISECGICSVHMNGELINSCQK
SIGKCSGADVVTIEGLGANGLHPIQQAFIDENVSQCGICIPGQLMAAAHMLNSNPEPTDH
EIDVAMKNNYCRCGAYTRIRAAIHAAASSA
>A0A5E7AJE2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSIKPLSRRGFLKGSAWLGGGLVVAFIIPGAHRFASGAENQGMVFAPNAFLRIGNDDSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHAPASAADYGLAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAARRFNVAPSQISTESGVVIAGDKRATYGELADDAGKL
PVPDPASIKFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPVFGG
SVKSFEGAEALAIPGVHIVVQVPTGVAVIADHYWAAKLGRDALKVDWELGPNTGLDSQAL
LENFRKLATTPGVSASTAGDTDGTLGKAVKTVDVEYSVPYLAHAPMEPLNCTVRITQNKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
GPVKTVWSREDDIRGGYYRSAFLHHARIGLDAAGLPIAWKHVLVGQSIMAGTSLEATMVK
DGIDKTSVEGVADSPYLAGLAHHQVDLHSPKTGISVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVDYRRTLLKDHPRHLGVLNLAVEKAGWKAPLPDGHALGVAVHESFGSYIAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPMSIAAQMESAITFGLGFTLHSKLTFKDGRVEQSNY
HDYQVLRLNEMPLVEVHIVPSSEKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E7LU83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPNDFALSNLSNLSRRGFLKGVGATSALVLAASWGWQDAFAEEASKKFGADGMPHGA
IDDPKVYVSIATDGTVTVICNRSEMGQGVRTSLTMVVADELDADWAKVKVQQAPGDEVRF
GNQDTDGSRSMRHWYEPMRRCGAAARTMLEQAAANQWKVPLGECHAQLHKVIHTPTGREL
GYGELAVAAGALAVPARDSVRLKDPSQFLYIGKEGTKAIDGADIVNGRAVYGADVHFDGM
LYATIARPAVYGGKVKTFDASAAMKVPGVIKVLQIGASPVPSEFQPLGGVAVVAKNTWAA
IKGRDALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNLEEAMDSADNILEASY
YLPHLAQAPMEPMVAIARFKDGVCEAWGPSQAPQVTRTRIGERLGIPFDNVKVNVTLLGG
GFGRKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSVEYLKAGLNKDGLPS
AWLHRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATAHTRVGWYRSV
SNIPHGFAIQSFVDELAHKAGQDPLKYQIRLLGPDRQIDPRTLSDEWNYGESTERYPIDT
ARLRTVLETAAKAAGWGRELPKGRGLGLAVQYSFVTYVAAVIEVEVKDDGTLIVHKADIA
VDCGPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNLHMYEVARMSLAPREVA
VHLVTPPGVVPLGGVGEPGVPPIAPALCNAIFAATGKRIRSLPVRFQLQGWQKEQA
>A0A5E6QQ38|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MTISPMDVSRRVFLKQTATVTGGLAIAFYLPSSLAATDPKAPATAGEFEPNAWVRILPDG
TVKLVVHKHDSGTGTHTALAACVAEELEVNPMTVQVISPEDPFFETYIHPIWKVFSTGGS
TSVSLEYDRLRMAGATARALLITAAAKQWKVSPDSCITEEGRVVHGASKRSLGYGELVGV
AAHLPAPAKVSLKDPAQFKYIGKLRHKRDAQAKVCGRFKYSIDVDLPDMLVAVIQRAPVL
GANVVSVDSAAALQVPGVRKVIKVPGRPDVLGGNVEGVAVLADNYWAAHQGRELLKVQWS
DSPLAGFDSDELVKSQAAALDDKGAQRVSAMAAGDVSGQWQNAAKLLEADYRMPYKVQNP
LEPICITAQVKDNAITYWGGVQVPSSALEAAQVICKFTKDNVIINERVSGGSFGAREAKY
WLFEVAYLAQQARVPVKLMNSREDEMRSLFMHPATLHRAKGALDAQGRLTALQLDAVSPA
SPEQWEPGYFERPDKMDYSTTEAITAWDFAYRPANLDLTWVRHESQVPSGWYRSVSFIPN
VFAVESFMDELAHGAGQDPLAFRLANMKDRPRHVAVLQSAAERAGWGQPLPEGTALGIAT
NQGYTSFIAVVARLSRKDGVIKVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHALFDR
MDIKQGRVVQSNFHDYRVTRMSDMPAVDILVVDGEPGKPGGVGELGSPSVAPAIANALFS
LTGVRQRSTPLVLG
>A0A5E7M2X3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MPTAIPSWRQIARPHNFQTYAGVPMITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKF
GCGMGLCGACTIHIEGAPARSCITPIGSVVGQNVTTIENLHVDPVGQVVQQAWLDTAVAQ
CGFCQGGQIMSATALLKTHPNPSDEQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7WDX5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MPTANPSGGRLLDPITNNYAGVPMNTLKLNGQDYKMDVPDEMPLLWAIRDVAGGHPGTKF
GCGMGLCGACTIHIDGQPARACITPISSVNGQNVTTIDELHNDPIGQVVQQAWLDTAVAQ
CGFCQGGQIMSATALLKTNPNPSDEQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E8H4W2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11)|TrEMBL
MTKFILNSRPVEYTNPPEEMLLLILRDTANLKGTKYGCGAAMCGACTVHVDGEAMFSCQM
SLADVEGADVTTIEGLSEDGSHPVQKAWIEEQVPQCGYCQSGQIMRAAALLAENPEPSRE
EIVDTMSANLCRCGTYNRIFKAVERAAKEA
>A0A5E6MXP4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNLINELLDTPVNLSRRRFLASTAVGALVIGFGLPLGSGRVQAATTAERGTQVPAFLEIR
PDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAYVVMENGMRITGG
SMSVRMSYPTMRRLGALARAMLLQAGAEQLAVPVSELTTQPGRVVHAASGRSLGYGELAS
RALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKVDNMLHAAVQHA
PRLGMTVGSLRNQPQVEAMKGVHSVHVLPGAVAVVAERWWHAKRAVEAIQVDWQEAAADS
TLRVMPADFSSDRHRDFLAAQQGPARDDENEGDVAAALKGAKTQLEATYHNQYLNHAQLE
PPSALARFNPDGTLEIWLPNQAPDMFRADIAKRTGLDPANIILHSPLLGGFFGRHFLYDS
ANPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPLAVVKFRAALDDKGLPIAIEAVSAT
EGPTEALAGKQGDKIDPTAVEGLSGKSYAIPNKRIAQIYVKGAPMLGYWRSVGNSLNDFF
YESFLDELADKGGHDPYELRLHLLRDNPRLTTLLQAAGELSGGWKRGPFTAEDGTRRARG
VAMASPFGSHTAAIAEVSIEGGKVKVHDIWQAIDPGSIVNPAIVEAQVNGAVALGLSQTL
LEEAVYVDGKPRARNYDLYPILAPAQMARVHVRVVESGEKMGGIGEPPLPAVAPAVANAV
AQLTGQRIRSLPMSRHTFS
>A0A5E7EBQ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNTRPELLDLLSGEPVNLSRRRFLASTAVGALVIGFGLPLGSARVQAAATVERGTQVPAF
LEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFVVEAAPPGEAYVVMENGMR
ITGGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPLAELTTQPGRVVHAASGRSLGYG
ELAGRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKVDGMLHAA
VQHAPRLGMTVGGVRNQAQVEAMKGVHSVHVLPGAVAVVAERWWHAKRAVEAIQADWQEA
ASDSTVRVMPADFSSDGFRDFLAAQQGPARDDENEGDVAAALAGAKTTVDATYHNQYLNH
AQLEPPSALARYNADGTLDIWLPNQAPDMFRADIAKRAGLDVAKINLHSPLLGGFFGRHF
LYDSANPYPQAIALAKAVGRPVKVIWSREEEFLRDVLRPVAVVKFRAALDDKGLPVAIEA
VSATEGPTEAIAGKQGEKLDPTALEGLSGKAYAIPNKRIAQIYVKGPVMLGYWRSVGNSL
NDFFYEAFLDELADKGGHDPYELRLHLLRDNPRLTTLLQAAGELSGGWKRGPFTAEDGSR
RARGVAMASPFGSHAAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVNGAVALGL
SQTLLEEAVYVNGLPRARNYDLYPILPPSRMARVHVRVVESGEKMGGIGEPPLPAVAPAV
ANAVAQLTGQRIRSLPMSRHTFS
>A0A5E6S567|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGHKFAYAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMPGFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFEVAPSAIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGASV
KSFEGAEALAVPGVHKVLQVPTGVAVIADHYWAAKLGRDALKIDWDLGPHADLSSEKLLA
SFRKLAGTQGTSASQAGDAKGSFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAEKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMP
VKTVWSREDDIRGGYYRSMFLHQARIGLGADGLPSSWQHVLVGQSIMTGTLMEATMVKNG
IDPTSVEGVSDSPYVKGLANHQVDLHSPQTGINVLWLRSVGHSHTGFVMESLIDEMATAA
GKDPVEYRRTLLKDHPRHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLKDGAVVQSNYHD
YQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>A0A109KLY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNTTEIIPGVALGEPINLSRRRFLASTAVGALVIGFGLPLGTSRVQAATGAAAERGTQVP
AFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAYVVMENG
MRITGGSMSVRMSYPTMRRLGALARAMLMQAAAEQLRVPLSELTTQPGRVVHAASGRSLG
YGELAGRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSIGKAQYTIDLKIDGMLH
AAVQHAPRLGMTVGSLRNQVQVQAMQGVHSVHTLPGAVAVVAERWWHAKRAVEAIQVEWL
EAAADSTVRAMPADFSSDKYRDFLAAQQGPARDDENEGDVAGALASAKTRVEATYHNQYL
NHAQLEPPSALARFNPDGTLEVWLPNQAPDMFRADIAKRTGLSTEQITLHSPLLGGFFGR
HFLYDSANPYPQAIALTKAVGRPIKLIWSREEEFVRDVLRPVAVVKFRAALDDKGLPVAI
EAVSATEGPTEAIAGKQGDAIDPTALEGLSGKSYALPNKRIAQIYVKGPAMLGYWRSVGN
SLNDFFYEAFLDELADKGGHDPYELRLHLLRDNPRLTTLLQAAAELSGGWKRGPYTAEDG
TRRARGVAMASPFGSHAAVVAEVSIENGQVKVHHIWQAIDPGSIVNPAIVEAQVNGAVAL
GLSQTLLEEAVYVDGKPRARNYDLYPVLPPSRMAQVHVKIVESGEKMGGIGEPPLPAVAP
AVANAVAQLTGQRIRSLPLSRYTFS
>B8KU19|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luminiphilus syltensis NOR5-1B|TrEMBL
MIKLTVNGVAHQFDGDTSTPVLWFLRDELNLTGTKFGCGAAQCGACTVHVDGKAQRSCVL
PISAVDGASLTTIEGLDPEGNHPLQKAWIEHQVPQCGYCQGGQIMQAASLLDKNPSPSDQ
DIVDAMSGNLCRCGTYTRIHKAIKSVAASTLSQNDSGVQQFEPATRGRGVVV
>A0A5E7EC68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKTYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREVTTIEAIETDDVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPAPNKA
QIDAAMINLCRCGTYNAIHTAVDELAKQEGV
>A0A5E7P5K9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSALLGGGLVVAFAVPGGHRFAMAAENEGKVFAPNAFLRIGADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSTIGVEHSPASAADYGMPAFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFDVAPSTIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVVRAPVFGATV
KSFEGAQALAIPGVHKVLQVPSGVAVIAQHYWAAKLGRDALKVDWDLGPHADLSSEKLLE
SFRKLATTPGTSASQTGDAKGNFSKAAKKIDVEYSVPYLAHAPMEPLNCTVKISEQKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAGLP
VKTVWSREDDIRGGYYRSMFLHQARIGLGADGLPLSWQHVLVGQSIMTGTLLEATMVKNG
IDPTSVEGVSDSPYVKDLAHHQVDLHSPQTGINVLWLRSVGHSHTAFVMESLIDEMATAA
GKDPVEYRRTLLKEHPRHLGVLNLAVEKANWTAPLPEGHALGVAVHESFGSYVAQVAQVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLKDGAVVQSNYHD
YQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVYALTGQRLRELPLQLSGV
>A0A017HIY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubellimicrobium mesophilum DSM 19309|TrEMBL
MRALSEGTQWTESETLPDQAKLPDALRSLESEVGTVSEAGQHGVPEGDHSLRMTFSRPYM
MHGSIGPSCALAHMDGDQLTVWTHTQGVYPDRKAIAEMLGMDEAKVRAVHVEGSGCYGHN
GADDAAADAALIATKFPGRPVRVQWMREQENGWEPYGPAMVMDIAGRVDEQGRISHWTYD
LWSNTHSTRPGPAGALIAGRLMAKAFQPEEPKLQISPNGSGDRNADPYYTIPNKLVQWHF
LKEMPLRVSALRALGAYANVFALESFMDELAILAGTDPVEFRLRHLEDPRARDVVERAAQ
EANWSSDPLPPGRGRGFAFARYKNHAAYLALALTLEVEPETGRVRVRNVIAAIDSGEAVS
LDGIRNQTQGGIMQSLSWTLYEQVTFDRTRVTSIDWASYPMLRFTSVPDSIEVHVMDRPG
EPFLGTGEAAQGPTPAAVGNAIRNATGVRMVNLPLSPDRLQAALNA
>A0A7W8HEL4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Quisquiliibacterium transsilvanicum|TrEMBL
MSMRVQDASQVLNLSRRGFLQGVAAGSLVLASGLPGALAAEPKKYGAHAMSGGLKDDPKV
FLSIGEDGLVTLLCHRAEMGQGVRTSWAMVVADELEAELSRVQVGQSPGDEARYGNQNTD
GSRSMRHHFDALRRIGASARRMLEEEAASRWRVPLAEVRADNHALVHAPSGRRLGFGELA
KGASARQVPARETLSFKPVERFRYIGKEGMGLVDNVEITTGKARYGIDSWARGMAFAVVA
RPPVYGARLKRFDSSRAERVPGVLKVLPIDFPGIPSAFQPLGGVAVIAENTFAAIKARGL
LEIEWDEGPNAQYDSARYRETLEAAARRPGKVVRDQGSVDAALAGAARRVEASYYIPHLA
HATMEPPSATARVTAEGCEIWCSVQNPEAIRIDLSKRLGLPMEKVMVHPLLLGGGFGRKS
KPDFAIEAAILSRAMDGRVVKLTFTRDDDLHHGFFHTASVERIEAGLDASGRPVAWLHRT
VAPTILSIFVPGAKNEAPFELGMGAVDVPFAIPNLRVENPEAEAHTRIGWFRSVSNIPHA
FAIQSFAAELAAAAGRDPKDYLIELLGPDRSIDAAEMSDGWLYGEDPKRYPFDTGRLRRV
IERVASEAGWGRRLPKGHGLGIAAHRSFVSYAAAVVEVAVGPKGEVRVPRVDIAIDCGAV
INPDRVRSQLEGAVIQGLSLAMTGEISFRRGRVEQSNFHDYTIARIDEAPRDIRTHLVIP
TGYDSPLGGVGEPGVPPVAPALCNAIHAATGKRIRSLPIRGQLA
>V4RIG5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lutibaculum baratangense AMV1|TrEMBL
MTGVRSGGALVVTGAGRLGRETYLRITGDGRVSAYNGHVDLGTGLRTALAQIVAEELDVD
PADVEMVLGDTSRTPDQGPTIASESIQIAAVPLRNAAAQARHALLARAARAFNAAPEELQ
VENGEVFVAGGDRRIGYGALIGEETIELELSADVAVKPVAEHRIVGTPHKRLDLPGKATA
QITYVHDVRVDGMLHGRVVRPPYAGRDTGDFVGNSLISVDEGSIAHIPGIVAVVVIRDFV
GIVAEREDDAERAMRALKVAWREPPPLPDLGDVPNALTSNPSTPRTLIDRGDVDAAIDGA
AKRLERRYVWPYHLHGPIGPSCSVAHWQGDGLTLWSGTQNPHMLRADLSRLLEIPEHRID
IRRHEAAGCYGRTCMDDVGGDAALLSRAVGRPVRVQLSREQEHAWEPKGAAQLMEVRGGI
AADGSPSGYDFETRYPSNRGPNLALLLTGVVKADPQPSDMGDRTAIPPYAYDDMRVVVHD
MAPIVRAAWMRGVSAMPNSFAHESYVDELAAEAGVDPVEYRLRYLQDERAKELVKETAER
AGWAPRTAPRLVAEGEIAYGQGFAYAVYVHGTFPGTAAAQAAWVAEVAVNRRTGEVVIER
VVAGQDSGMMINPAGVKHQIHGNVVQSVSRVMKEKVAFSDTAVATKDWGSYPVLNFPELP
RIEVVMMPRQSEPPLGVGESASVPSAAAIANAIYDATGVRFRELPFTPERIRAGLEGTAL
PPPAKAPSRPRRRLLGQLTTAAAAALTTAAVAWSWHTPIARIAPPDPSVWSAATIERGRQ
LASLGACAVCHTAEGGAINAGGRGIETPFGTVYATNITPDAETGIGAWSYTAFERAMRKG
ISRDGHHLYPAFPYTSFARTSDADMQALYAYLMSQAPVRAEVPESRLAFPFNLRAAMAGW
NALFHRPGTLEPDPARSEAWNRGRYLVEGLGHCSGCHSPRNALGAEKTGRLHLAGGMAEG
WEAPALTALSKSPVSWTENALYQYLRDGWSPHHGSAAGPMAPVIEELRELPDKDIRAMAT
YLGSLNDAPADGDLASLAARLASESHARLVEGHEAGARLFENACAICHGADALAAPDAPA
IPLALNSSVHSDRPDNLIRVLLEGIPLPPRPLSGSMPSYAGAYSNGQIAEIAAYVRARFA
PDRPAWEGLEDAVGHIRGG
>A0A165RR83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. W74|TrEMBL
MAISLKLNGQTHKVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLDGEPVRSCQ
TFIEDVEDSEITTIEGLKSTPAQAVQQAWTELDVVQCGYCQSGQIMSAVGLLSENAKPTL
EEIDDYMDGNACRCATYQRIRSAIVRASEIMEA
>A0A381EXF8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chromobacterium violaceum|TrEMBL
MTTTGVSRRGFLKMSGAVGGALCLGFVLNERGGKAEAAEAKSAIPAPNAFVRIEKDGGVT
IVSNKSEMGQGIYTSLAMLIAEELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLS
SYDQYRKIGAAARDMLIAAAAQRWRVPASQCRAENSRVFNNANGASLGYGELTEAAGKLP
VPDTVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPK
GFNADVARAVPGVRDVFAISNGVAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRAD
YRARAATPGQTYRSEGDAEAALAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCEIW
SGTQSQTLDAGMAAAMAGLKPEQVSLHTTLLGGGFGRRAVPAGADWLKEAMEVAKRHGQG
APIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGTPFAPMMIK
NGIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESYIDELARLA
RQDPVAYRLALLGKAPREQGVLREAARMAGWGRKLPKGHGLGAAVHSSFGSHVAQVVEVS
LKGKELKVEHVWCAIDCGVVVNPDQVAAQMEGGILFGLSAALFGEITFKDGEVEQKNFDG
YPIVRMFQAPKVDVSIVASEEAPGGTGEPAVPVVAPALANAIHAASGKRLRELPLSRHGY
QAV
>A0A484P5U6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MSNASVSGQEPPVAGVAPGLSRRAFLNAAGALVVWVVTPGCARTQERSDWTSRALSDRIE
LRSDGTVHLHIGRIEMGQGLYAGVMQLAAEELDLPMARFRVAPVDTASAPDENFTDASAS
MRRTGMAVRRAAATARAVMLALAARQWRIGAASLRVENGIVRSAAGHRTDYWRLLAEANG
KALPAARGSLKAPEAYRLLGRSVPRPDLPAKVTGAAVFVQDLRLPGMLHARVLRPPSLAA
SLEASDTQAAATMPGVVRVLRNGSFLAVVAQREEQAIAALEVLRAGCRWHEPATLPDPAG
LYAYLRSEAGLPEIVPSSGDRRLTATYEVPYRMHASIGPSCAVAQFEDGRLTVWTHAQGV
YPLRASLASLLDLPRRAVRCIHLEGAGCYGHNGADDAAADAALIAQAVQGAAVRLQWSRE
DEHGWEPYGPAMVMRLSGTLDAQGRISAWHHAVASPTHSSRPGGAARLLAARHVEPAIAP
SFLHGLTTWAGGGRYNARPYYRVLASVESHLVRRAPLRSSALRSLGAYANVFAIESFMDE
LAEQAGADPLQFRLAHLDDTRAADVLRLAALRFGWEQGRAQSHGIGFARLNGYGAYIAVC
AHATVESDGRARITRIVAAADCGELINPDAVRNQIEGGIVQAVSWTLYEQVRFDRTRITS
TDWSSYPILRITEAPGVEVHLIDRPGADYLGLGEAAQGPAGAAVANAVARLRGHRHRTLP
LHVGGAG
>A0A7Y9RML3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. IAR9|TrEMBL
MNAHDSVSRRALLTGGLATGFLLAFHLPLRAAVNEPVQPRDATEGKFAPNAFIRIDETGR
TVLMMPQVEMGQGTYTSISAVLAEELDADWSRVEVQHAPPNDKLYGNPTFGLQVTGNSNS
IRAWWLPLRKAGATARAMLVQAAAAQWGVEPASCTASKGEVAHEASGRKLAFGALALAAQ
GQTPPKDVALKDPKDFVIIGQPLKRLDTPDKVNGKAVYGIDAILPGMKFATVAACPVFGG
KVGKVDDSAAVKLPGVRKVVVLDDMVAVIGDHMWAAKKGLEALKIEWNEGPNAAITTKDV
WDDLRKASQKDGAVAKSDGDIAKALASGDKFEAAYELPFLAHASMEPINATVHVKPGSCE
IWTGTQIMTRVQSEAAKAAGLPVDKVIVNNHLLGGGFGRKLEPDMVIAAVKIAKQVDYPV
KVVWTREEDIQHDVYRPVYRDQITASLVDGKVAGWKYKVAGSAVLARWLPPAFQKGIDID
AIDAAVDAPYDFANFHVEYVRAEPLSVPTGFWRGVGPNNNVFAVECAMDELARKAGKDPI
EFRKSMLTKNPRMLAVLTQVAEKSGWGQPLPPRVGRGVCVQPSFASFIATVVEAEIDDIG
EIVLRRITSVVDTGIAVNPDTVKAQIEGGLIFGLTAALYGEITIDKGRVQQSNFHDYRMM
RINETPKIEVIVAKSGEAPGGIGEAGVNAGPPALRNAILAATGVALRRLPIDRKLLAAGK
KA
>A0A094YY86|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter tropicalis|TrEMBL
MLLTAAAARWNIPQHLLAAENGYIKDHTGQHCAQYGDFAVDAARQNIPQNVPLKAPSDWK
LIGKSFPRVDIPAKTNGTAVFGIDVRVPEMAIGAVMGAPVIGATLDTLDDTLCRTIPGVL
NVLKTSTAVAVIAKNYWTARKGLAALKIKWVEGKNSSLSSEDIRRKIRDASLSVPEIIAR
DDKPKNTSAESGKKLEAAYELPFLSHAPMEPANVTLHVRAEHCDVWMGTQVPTRARAAVA
KITGLPPKKVAIHNHMIGGSFGRRLATDFLEQATHFACQVSHPVKFIWSREEDIRQDLFR
PAYYDRISATLGQNGQPLSWQHHVSGPSVVDRFAPGGLPAGKLDTDAVAGAVDTPYDLPQ
MFVTWTRADTPVPVGWWRGVGPAHNVYVVESFIDELATATHTDPLEYRLRLLGKNPRSVA
VLKRVAEESQWSKPLPTGTGRGLALHNAFGSHCAVVTEAVVTEKKSITIKKVTAVVDCGI
AVNTDALIAQMEGGLLFGFSAALYGEITIKNGRIEQSNFHNYPLMRINDAPPIDVHIIKS
TDNPGGIGEVGTTAAFPSLGNALFNATGKRCRRYPFSPHFFNGDYGSI
>A0A7Z0BCH4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MSQGLLDAGNGAQPSGAKAGRVSRRTFLKFGVTVGAAAGGGLLLGFSLPAASQDQKAGKS
VIGGDGVETPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVPLDS
VTVDHAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRRAGAAARVVLIQAAAQQWQVDPA
SCHAQAGQVIHAASQRSLGYGQLADAAAKLPAPQNVPLKNPKDFKLIGTSPKRLDSPEKV
DGTALFGLDVRVPGMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQIVKIDNAVAVIGDH
TWAAKRGVQALDIKWNEGAGAAISMQQIVGDLATASERNGAVARKDGDVGKGFSDAKTRV
DAVYQQPFLAHATMEPINCTVHVRPDGCDVWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LIGGGFGRRLEFDMVTQAVKVAKQVSSPVKVTWTREEDIQHDMYRPYYYDKISAGLDANG
KPIAWQHRIVGSSVIARFAPPAFKNGIDPDAVEVAADLPYDLPNQLIDYVRQEPHAVPTA
FWRGVGPTRGTFVVESFIDELAAQAKVDPVKYRQDLLGKTPRALNVLNVATQSAGWGSAL
PKGQGRGVSVMHAFGSFFAIVVDVAVDQGEVAVKRVVCAVDCGMVVNPNTIEAQVQGGII
FGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIEVHIVKSGEAPGGIGEPGTAALA
PALTNAIYAATGKRLRHLPVGSQLQTA
>A0A1Y5S6X2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoruegeria aquimaris|TrEMBL
MRLTVNGTEHEVEVEPEMPLLWVLRDELNITGPKYGCGIAQCGACTVHVDGVAVRSCQLA
IGDLAGGEVTTIEGLGQPESLHAVQQAWVEHQVAQCGYCQSGQIMQAASLLDFNPAPTDA
DIDAAMSGNLCRCGTYPRIRAAVKAAAQKLQGA
>H0T6J3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MANLTINGKPYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGV
TVSEAAGKQITTIEGLASDNGLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSD
QDINDAITNICRCGTFAQVREAIHAAANA
>H0T534|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARSCIT
AISDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNENPKPSHD
QIRDAMSGNICRCGCYQRIENAVHLASTGV
>S9RUY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Litoreibacter arenae DSM 19593|TrEMBL
MRIVPSNEPPTGVVEPGVPPIGPAVANAIYAATGKRIRQLPIEKALRA
>A0A1T2ZL31|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MQLRINQKAYEVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAAVVGREVTTIESIEADDVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPAPTDA
QIEAAMINLCRCGTYNAIRTAVHELAAQPARTESA
>A0A087PNF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MITLKINGKDYSFDGNPEMPLLWYLRDEIGLTGTKFGCGMALCGACTVHVDGVPARACVL
PVGAVNGPIATIESVSETPVGKAVQDAWTQVQVPQCGYCQSGQVMTASALLTQKPQPTDA
DIDAAMSGNICRCATYNRIRQAIHDAAKELG
>A0A1X1PKQ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia puraquae|TrEMBL
MPTSFVLNGKNVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTVHLEGQAVRSCV
LPLAGIAGKHITTIEGLQSKPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
ADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
>A0A5P2WZ14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces spectabilis|TrEMBL
MGLRRKATAGDGAGVERPEAAGPGGGGVGRRRFLGFVLAAPTLVTAAELGTAPAAEAGTA
LPEITDLVDLNDVMTTAALPTSHLVTVEVHEDGTVSFALPRAEVGQGITTSTAMLIAEEL
GVPLERVRVTLADARPELVFNQLTGASNTTISTYAPIRVAAAVARERLLRAAADVLGSPA
GGLSLEAGVVRSRAGGSVGIRELARKAASVTVRRVAVELKERGRFTVIGRPHNRIDALAA
VTGRKKFAMDLDVPGALPTMVCRAPTLNGRVGSVANLEEVRAMAGVTDAGVVSTGVAVRA
RTFGQCIEAVRALRVAWRPGTAEGSSDESVLEELREAELPLGLPPLTKSVEARFTFHFRG
NSALEPNCAIADVRPDGAEIWSALKAPIVAKQAIAARLGLPPGAVRVHVTEGGGSFGRKL
FFDAALEAAEISRKFGKPVKLMWHRADDARQGRAHPMATSRVRAAYAGDTVLSFKQRHTS
VATDFGHGLGEVFTALAAKLPVGDAAFSQTFFHLTQSMPYAFGVHSRLLSETGKGFNTGS
MRGVYSPDVVCARELIVDQLAAKTGRDPFGFRREALRDARARAVLEKAAEAGDWGRRLPE
GMAQGIAFHGEYRAASAVLVEIDCRRQTVERPVRDGVSGPRVTKAVVAVDVGLAVNPRGL
EAQMMGGVMDGIAQALTSSLHLREGHFLEASWDNYFYTRQWNTPLELKVVVMPPTTGEPG
GAGELAVAASMAAVACAYGRATGSMPTRFPVNHGTLSFVPKPTVPPVPASPTDGLDHVR
>B1GAS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MSQGLLDAYKGAKRPQAEADEARGVSRRTFLKFGMSVGAAAGGGLLLGFSLPAVSQDQKS
GKSVIGGDANEAPQNGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LDTVTLDHAPPDEKLFTDPLLGGQLTGGSTSIRYAWEPMRRAGAAARTLLVSAAAQQWQV
DAASCHAQAGQVIHAASNRSIGYGQLVEAAAKLPAPQNVPLKNPKDFKIIGTAVKRLDSP
EKVDGTAMFGLDVRVPDMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQVVKIDNAVAVI
GDHTWAAKRGLQALDIKWNEGADAKLSMKQIVDDLANASQRNGAVARKDGDVVHAFSNAK
TRVDAIYQQPFLAHATMEPINCTVHVRADSCEVWLGSQVPTRVRDAAMAVTGLPADKIIV
HNHLIGGGFGRRLEFDMVTQAVKIAKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLD
ANGKPLAWQHRIVGSSILARFAPPAFKNGLDPDAVEVASDLPYDLPNQLVDYVRQEPHAI
PTAFWRGVGPTRSTFVVESFIDELAAEAKVDPVKYRRDLLGKTPRALNVLNVAAQAADWG
SAVPKGQGRGVSVMHAFGSYFAIIVDVAVEQGEVAVKRVVCAVDCGMVVNPNTVEAQVQG
GIIFGITGALYSEITIKDGRVQQNNFTDYRMLRIDQTPPIDVHIVKSSEAPGGIGEPGTA
ALAPALTNAIFAATGKRLRHLPVGSQLQTA
>A0A346BHQ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinilytica|TrEMBL
MSTSFVLNGKNVTLDADPTTPLLWAIRENAGLHGTKFGCGMAQCGACTVHLEGEATRSCV
LPLAAVAGKRITTIEGIESRPAKAIQAAWVKLQVPQCGYCQSGQIMSATALLEHNATPTD
ADIDAAMNGNICRCATYTRIRAAIHEAAATLKA
>A0A095AVR1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter tropicalis|TrEMBL
MIKFKLNGRDVSVDVPDDTPLLWALRDELDQTGTKFGCGVGQCGACTVHVGGRATRSCIT
PVSSIEGAEVTTIEGLHPEGKHPVQEAWRDIQVPQCGYCQSGQIMQAASLLKDYPDPTDE
QIDGVMGGSLCRCMTYIRIRKAIKKAAAAMREETASNG
>A4FDX7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)|TrEMBL
MPEYTFILNGRQVTADVPEDVRLLWVLRDVLGVTGPKYGCGINVCKACTSHHNGKAFNPC
SVPVKDIAPTDEITTIEGLPATVGEDLHPMQEAWLEHDVAQCGYCQPGQIMAAVAKVRQA
RAEGREIGDADLDEIRNICRCGTYFRIREAIRAGAEKM
>A0A0H3YUF7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas stutzeri|TrEMBL
MLTLSINGTDLQVDVPEDMPLLWVLRDVLGLTGSKYGCGIAQCGACTVHLDGQAARACVL
PVGEVKGRKVVTIERIGNTELGRKVQQAWLEDEVVQCGYCQCGQIMSAVALLEQNPQPDD
RAIDQGMAGNLCRCCTYTRIRSAIKRVAQA
>A0A0T5PCY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius indicus|TrEMBL
MSRLGTITRRAFLVGSTAVAGGVAFGVYTVRKPHANPLEDGLADGEAALTPYVRIDAEGV
TLITPRADLGQGAYHVQAALLAEELDVDLEDIRVDPGPPSGAYWNTAMAEEAAEFMVPSQ
GILQAGAATVVGSVMKVMGLQITGGSTTVPDGFDKLRAAGASARETLKAAVAAREGVSVG
DLTTEAGHVVLPDGTKVAYAELASDVAGMGVVQNVRLRQPEEWRYIGKPMRRIDMVAKST
GTQDYGIDVEIEGMVHAAIRLNPAQTGPLNSFDASEAEQMRGVKAVVPVTGGVAVVADNT
WRAFKAAEAVKVKWGKAPFPASMEQHWAALGEAFAEDTLDSRNRDDGDVDGALGEGEVIE
AEYRAPYLAHAPLEPISAVVRVDDDGAEVWTGTQIPRFVQQNVARVAGVDADNVVVNVLM
MGGSFGHRLEDEVVKQATEIAVTMKGTPVKLTYSREEDMTHDFPRQIAMGRVRGKVAGGR
VETMDLSIAMPSVMASQMGRQGQPVPGPDSQIVAGAWNAPFAIPNHRVTGYRAPELAPIS
SWRSVGASSNGFFYNAALDELIDAAGADPLEERLRLCDDPLARQVLEAVADMSSWDGPLG
EGRGRGVAFVQSFGVRCAEVVEVSQGDRGLNIDKVWVAAEVGRVVDPVNFENHIQGAVVW
GLGHAMNCEITYADGRAEQSNYHAFEGMRMWQTPEIMVRGLENGERVTGVGEPPVPPAAP
ALAGAIFAATGKRLREMPFSKFVTFA
>A0A853SPG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MTTLTINGKQHELALPEDTPLLWALRDELGMTGTKFGCGMALCGACTVHLDGEAIRSCVT
PMSAAAGKNITTIEAVGEDKVGLALQQAWQEHGVPQCGYCQAGQIMSATALLHKTPRPND
QQIREAMSGNICRCGTYTRIHAAIKQAATSIHAKGAAK
>W6VJJ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. GM30|TrEMBL
MNVRIDPAQEASALALHEPINVSRRRFLAGTAVGALVLGFGLPLGATRVQAAVAAATAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPSTFLVEAAPPGEAYV
VMENGMRITGGSMSVRMSYPVMRRLGALARAMLLQAGAQQLGVPVSELSTEPGKVVHARS
GRSLAYGELAEHAMDLPVPDPASVQLRDPSQFRWIGKPVKRVDAYDKSTGKALYSIDLTV
DDMLHAAVQHAPRLGMTVGNLRNEEQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTADSQVRSMPADFSSDAWLKRLADDKGPARDDENEGDVAAVLASAKTRIDATY
HNQYLNHGQLEPPSALARFNPDGSLEVWLPNQAPDMFRADIAKRTGLDPSRITLHSPLLG
GFFGRHFLYDAASPYPQAIELSKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRAALDNDG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYAKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFELRLHLLRDNPRLTTLLQAVGELSGGWKRGPF
TAADGSKRARGVAMASPFGTQTAVIAEVSIEHGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEEAVWIDGKPRARNYDLYPILPPSRMARVHVRVVESGEKMGGIGEPPL
PSVAPAVANAVATLTGQRVRSLPMSRHTFS
>A0A157S4A7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella ansorpii|TrEMBL
MTATPRTHTITVNHATHTVDTAPDTPLLYVLRNDLALNGPKFGCGLGECGACTVLVDGMA
ARSCVVPIRGVQGRAITTLEGLGTRGAPGPVQQAFIDHQAAQCGYCLNGMIMSAQALLLH
NPHPTEDEIRQALQYNLCRCGTHLEILAAVRAAAARGLA
>A0A7W6J5V6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gellertiella hungarica|TrEMBL
MATLGKIARRTFLFGAAAIAGGVAFGYYKYSQPFENPLKKNLAPGEGTLNAYLKIAPDNR
MTVIVPRAEMGQGVTTTLAALVAEELEVRLDQLTVEHGPAAPAYYNSAALVEGAPVPRFD
QGLFADTLRGTMAVFSKLVALQFTGGSSSTIDAYEPMRRAGATAREMLKAAAAKRFGTQA
ANLKTAEGTITDTATGKTVTYGEIAAEAARLAPPEDIALKPRTAWTILGKPQPRTDMRAK
VTGAPVYGVDVSLPGLLHATIRMAPLPGQRMTSFDPAEARKMRGVVKVVEIDSPFGHGFG
VIADNTWRAFQAADAVSVAWSPPASIPDAKNVFATLAEAFETETPFSLRTLGDPVSAMAA
AAPGTVYEAEYRVPHLAHAPMEPMNATAQYKDGLLTVWAPNQSPSVVQMIGSRIAGVSAQ
DVVVHTTMLGGGFGRRLEPDFSDYAIRLALAAEGKPVKVIWTREEDMGHGVYRPAALARY
RAAVDKDGMPVAITGSLASQSVIAGMAGRIAPSIPIAGPDNTMLDGAYNQPYAFANHRIE
ARKVDLPVPVGSWRSVGYSFNAFMQESFLDEVAEKGGLDPLELRRRLLADNPAALGVINR
AAEMAGWGQPLAEGRARGLAYNLSFGTHVAEIVEVSGDAANGIRVEKVWCAADPGIVLDP
GIFKAQLMSGILFGLSAAMFQEVTWGPDGVEQLNFGDYPALRINQSPQVEIALLEQSPFM
GGAGEPGTPPSMPALANAVARLTGQRLRELPLSKAVAFA
>A0A1L3I2V5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter porticola|TrEMBL
MASLKKIARRSFLIGSAAIVGGVAFGTYKYHQPAPNPLAQEDGRAVLNPFVFVDQSGVTL
IAPRAEMGQGVKSAWASLIAEELDVDPAKVTVLHGPAAKAYYNSAMMSEALPGRGYDGSA
LQHSLGEIVGHMAKFLDLQVTGGSSSMRDGFERMRHAGASARETLKQAAADQLGVSRDQL
TTEDGHVVAPDGTRLPYSALANAAASLAPIEADLRPASEWRLIGKDVPRIDMVAKVTGTA
EFGVDVRLPGMKFAAIRQSPHFGVGKTAFDASATEGMAGVDKILDLGDAVAVVASNTWLA
QQAVDAIDVTWEAAPYPETTEAIFKEIARSFDATPNSTMRDDGDVDALPDGATVIEAEYR
LPYLAHATMEPMNATALYSGDALQIWAPNQGPTVVQKKAAALAGLDVDAVEVNTTYLGGG
FGRRIETDYTDRAVQIAMQMQGTPVQLTWSREEDMSHDVYRPGAIARYRAAIKDGKAVMV
HGKIAAQSTTVEGAGRMLGLPMSGPDKGHVDAAFNQPLAIPNFRVEGYLAKPMLPVGFWR
SVGASFNGFFSDCIIDEMAHAAGRDPLDFRLELARAEWEPAAKVLETVRDMSGWTGKTPD
GIGRGVAMAYSFGTPVAQVIEVADEDGQIRMTNAWIAADLGRVIDPKNTRAQMFGGMAYG
LSAACFGEITIDGGAVEQENFPDYDALRMHTMPTVQVELLENQPRMGGAGEPGTPPAAPA
LANALFDLTGKRARQLPLMHEFDLLI
>F4C2V0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium sp. (strain 21)|TrEMBL
MKDSLKRNGQYSQEEATRLSRKNFLKAAGLGSAALALGFYFPAGAHIVNILAGETAADNE
APLVSLNAWIHIDTNGQVTLFDHRAEMGQGSYHSVPQIIAEELEVDLKDIQVSFAPGNRN
EYGGQITGGSSTIRGSYKKLLKLSATARMMLVQAAANQWKVDVSTCYAASGHVIHKPSGK
KLHYGQLVVAASKLQPPKEVPLKPVSEYKQIRKASRRIDTPLKTNGSAVFGLDKRIPDML
FATVERNPRMRGTVRSFDDSDTMKIKGVTKVFKVRMKVFNTWREGVAVVADSTWAAMQGK
KALKVEWDDSNFEHISTPEIYRRQKELLSGQEGLIFQTQGNPSEVISAASTDAKLDVLYE
TPYQSHYAMEPVNCIAHWKGDTVEIWGPIQAPEMVQDAIAQEFSIPWQNVKVNMTFLGGG
FGRKAFMDYPFEAAAISKELGKPVQVVWTREDDATQGPYRPGMSYRCEGVVKAGKIEAMK
VRLCGQNIGHFSSNDRSKPNGSASEGFLKPYTQSIPHLSIADVTFELPIPVLWWRSVYAS
TNGFAYESFIDELAVAAGTDPLEFRRQHLPDERVHKLIDKLEAVSGWKSRGTNKGYGVAI
TECFNSTVGQVVKVSRIPGGGIKIDKVWAVIDCGWYVNPDIIHAQVEGSVAMGLGAAALH
EVTFTDGLVDQKNFYDYNMPRIADMPPVEVHIIDNAEDAGGVGEPGLPPFAPALANAVYD
LSGKRIRRLPFSLASV
>A0A5C5VCM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Posidoniimonas corsicana|TrEMBL
MTDRHSIKVNGQTHAVTTSSDRPLLDVLREDLGLTGTKYGCGEGECGACTVLIDGVATRS
CITSVEEVADASVETIEGLAGDELHPVQQAFIDQRAMQCGYCVPGQVMNAVGLLREKPHA
TEAEIVEAMSGNLCRCCNYRNLRAAVLQATR
>A0A839PK22|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. RMAD-H1|TrEMBL
MIHHSNPSSPITNISRRGLLAGFGAGAFVLAVGIPGNMSARAQEAKYGAEGMPNGIRDDP
KVFVAIADDGTVTVTCSRQEMGQGVRTSIALIVADELEADWAKVKVIQAQGDEARYGNQD
TDGSRSIRHFFMPMRRCGAAARAMLEEAAAKQWGVPVAEIEASNHEILHKPSGRRIGYGA
VAKAAAELPVPQGDAIKLKDASAFRYIGKGQTNLIDGFDMTTGRALYGIDTRLPGMVYAV
VARPPVYGGKVASFDDSEALKVPGVIKVVTIEPTPIPSEFQPLGGVAVIARNTWAAIQGR
SKLKITWDDGPNKAYSSDSYKATLEEAARKPGKVVRHAGDVDGVMAKAEKRLEAEYYIPH
LTQASMEPPAATVRIVDGKCEAWACVQAPQATRERLASRLGMLVEDVTVNVTLLGGGFGR
KSKPDFVVEAGLLSKAMDGAPVKVTWTREDDVKHSYYHTVSVERIEAALDASGKPAAWLH
RSVAPTIGSIFGPDPKHELPFELGMGLVNLPFDIPNVRLENPQAAAMTRIGWYRSVSNIP
HAFAIQSFVAELAHAAGSDHKDYLLEMIGPDRKIDPTTIDDSWNYGEDPKLYPLDTGRLK
RVIELAAEQIGWGRDLPKGRGIGLAAHYSFVTYVAVAADVEVDDQGVLTIHRMDVAVDCG
PQVNPERVHSQMEGAAIMGIGNTLFGEITFKEGRVEQSNFDGYEVARIDAAPKEIHVHLV
PAPDFSQPLGGVGEPGVPPVAPALTNAIFAATGKRIRQLPVKQQLGV
>F8GXB4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MMTTAQLSRRGFLKGSLGALTLAVTARGAVSTVWASETGPKKYGADTMPGGTVDDPLAFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVVQAEANEARYGNQNVDGS
RSVRHFFVPMRRVGAAARHMLEAAAAARWSAPIAEVRAVQHEVVHQPTGRRFGYGELAAD
AAKVPVPQVNALKLKDKADFRYIGKERVRLVDLEAIGKGLATYGMDMRLPGMVYAVVARP
PVVGGKLRRVDSAKALAVPGVLKVVEVPAFKGAPGFQPLGGVAVVARNTWSAMQGRAALE
IEWDDGPNGGYESAAYRQTLEAAARTPGKVVRNAGDALQAWSQAPRAERFAAEYYVPHLA
HASMEPPVATVQIRGDHAEVWTSVQNPLAAQRAVATRLKLRPENVKVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPAGTPVKLVWTRDDDIHHDYLHTVSAERLEAVVGKDGQVQSWLHR
SAAPTIASLFTEGAKGQQLFESAMSAINMPYRIPNVRVETAEVPAHARIGWFRSVANIPH
AFAAQCFIAELAHRARKDPKQFALDLIGTARKIDPGTLADNWNYTESPERYPFDTGRLRG
VIEAAARGAGWGRKLPKGHGLGLAFCYSFMSYTATVVEVAVDAKGEVRVVAVDMAMDCGP
QINPERIRAQMEGGAIMGLSLALSSEITFDKGRVQQSNFHDYEVLRHHASPRVIRTHLVN
DNHDLPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVV
>F8GX57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MGRVATITRRTFLIGSAALAGGVAFGIYKFKRELPNPLLHELSSGEAAITPYVKIDANGI
TLITPRGDKGQGAYSVQAYLLAEELDVDPLKVRLSPGLPDAAYYNGAVLEEAAPKPSYDD
SWLAERMRASMEAPAKLLGMQVTGGSSTVRDAFVKLRTAGAVARETLKEAAARQSGVPRD
QLKTEDGHVILPDGKRIAYTQLAAAAATLEPVRGIPLRSESQWRYLGKAVPRVDMMRKCT
GTEVYGIDFAVEGMVYASVRANPGIGAPVKRFDATKAEKMRGIKKIVPIRSGVGVIADNT
WRAFQAVNAIDIEWAAANYPGDQAELWKSLADSFTDKRRDSRPRNDGDVDKALRTGHVIE
AEYRVPYLAHAPMEPMNAVVRVMDDRCEIWTGTQIPGFVQEHAAKLTGLAKEKVLVHGLP
MGGSFGHRLEDTHVLQAVELAMAVKGTPVKLTWSREEDMSHDYPRPAGIARGLGAIKDGH
VEVYDLSIASSSVAASWLGRLMGAPPGPDQSIIAGAWDQPFAIPHYRVSGYRAPETVPVS
SWRSVGASGSAFFHDGFLDELIHAAGADPLEERIRLCHHDLSRKVLEAVGQMSGWNGPKT
EANRGRGVAFCMAFGVPVAQVIEVTKTSKGIRIDKVFVAMEVGKVLDPRNFEAQATGGII
WGLGHAIHGELTYQGHRPRQSNFTAYESLKLYQVPKIEVRALTNGSKIHGIGEPTVPPAA
PALANAIFAATGQRIRELPLRKHIEFA
>A0A5P2ZXR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium|TrEMBL
MSRTGTIARRSLLIGSAAIVGGVAFGVVKLNQPPANPLDPAPGQAALNPFIFIDRDGVTI
ITPKAEMGQGVQTTLAAMAAEELDLDWEQVRVLHGPPAAAYYNSTVMAGALPFREYDMGG
LQHALAEQVGKLGRVIGLQITGGSSSMVDGFERLREAGASARETLKLAAAERLGVAATSL
VTRHGQVIAPDGTAIPYGDLAEAAAAIDPPRVAPRDPSDWRYLGTSMPRLDQVAKATGTA
LFGIDVRMDGQKFATLRMNPNLGAGMVAYDATAALQMPGVEKIIDLGSGIAVVATNTWLA
FRAAEAVDITWQDAPYPPDQDGLWQAIDAAFDDKPNATLRDDGAPDTIPDGATIVEAEYR
VPFLAHATMEPMNATALYTGDALDIRCGNQVPTLVQARCAEAVGLAPEQVSVTTTYLGGG
FGRRGEYDYAVHAARVAREMPGTPIQLTWTREEDMTHDFFRPAAIGRFRGAVRDGKAVVL
DGQVAGPSVTASAMPRLIGMQASGPDKVHVEGAFDQPYRIPGYRIRGYLADLPLPIGFWR
SVGASINGFLHDTFLDEMAHAAGRDPLDFRLEMMRDEHAPSARCLETVAEMSGWTGKTPD
GIGRGVAFTYSFGTPVAEVVEVEDTAGGIRIARAWIACDVGIALDPDIVQAQMVSGLIYG
LSAAVMGEITFADGKVEQRNFFDYDALRMHNAPRVEVAVLETNPRMSGAGEPGTPPSMPA
LGNALYDLTGLRARELPFNKTFDFVT
>A0A085JFE1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tatumella ptyseos ATCC 33301|TrEMBL
MEMKAQQSVTQVSPAGLRCYSLKVNGEEREVTSYRDTSLLLVLRNELSLNSPKYGCGLGE
CGACTVLIDGVAARSCVIPAFGVRQRAVTTLEGLGSRYALHPVQQAFIEEQAAQCGYCLN
GMIMTTAALLRDLPCPSDLQIRSALSGNLCRCGTHQEILCAVKRAVQLSLQQAEAPQ
>A0A1V0Q1M1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MSRRTRLSRRLFLASAGGMTVAVGLGAGRALWPTPGPRAGQAVNAWAALLDDGRVAFACP
AQDLGQGAPLALSMILAAEIGADPGLVAVQAAPRDAGTYGNPDFDGRMVTADSKTTRGYW
PLLRLAGAEMRAALIATAARMQGWAEADCSTAEHSVAHRPSGARVSFAEIAANGRLRMPG
TPGLRPGVELTPLGTSPDDPRMRAIVTGQKRFGTDRRATDASVAVLARSQHLDGLPLTVD
DTAARAVPGVEAVVILDDAVAVVARHTWAALKGREALVVRWSDPGGFDSETEAETLRAAL
DDDSQKCVTLRATGVATGAPTLTARFHAPMLKHLVPEPLNAQARGKDYGLGVTVESATQS
LDLDMRFAAQTWKTAPFMVETIAHPAGGAYGRRVLNDVVRDACAVTKSLGRPVQVIRPLV
DELQRGQVRPAAAQRVAAWLAPDGTLSGWSHDFASDGPLAAQLPASLKGANGDEDNTATD
GAYHPYRVPADRIRWTRVATQPVPGFLRGVSAGYTVWAVETMMERLARTAGQDPLAFRLA
HIDDPRLATVARRAATMAGWGAPDRALGLGVMSFRGSHVACVAEVRDNRVAGLWLAADVG
RIIHRDNVVAQIMGGMVWGLSMALVEGLDFANGAARAESIWDYPVIGADALPPLDIALIE
PDPEAAPCGVGEIGVPTVIPAVCNAFECATGRVFDRLPLEVS
>A0A7W8XYM9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium paranaense|TrEMBL
MAFTLQINGHPHSVDVDGDTPLLWVIRDVLGMTGTKFGCGQALCGACTVHVDGVATRSCV
TPIDSVADSEITTIEALGTLPHGTALQNAWIELDVPQCGYCQSGQLMSAAALLSDVEHPT
DEDIDNAMSGNVCRCGTYQRIRAAIKLASA
>A0A5E8AI96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Imperialibacter sp. EC-SDR9|TrEMBL
MHTKSQTMASLTLRINNKDYPMEVDPQMPLLWAIRDFALLTGTKFGCGISQCGACTVHID
GESVRSCVTPVSGAVGKSITTIEGLSADNDHPVQQAWQEEQVPQCGYCQSGQMMTAAALL
EKHPQPSEEQVNAYMSPIICRCGTYVRIKKAIDKAVEINQKA
>A0A7W6T298|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. SBR1B|TrEMBL
MPTLTINGRSLSVDAANDTPLLWAIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
MLSDVAGKKITTIEGLSAKGDHPLQKAWVAEQVPQCGYCQSGQIMQAASLLSKNPNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAASEMRTASATSTERRPT
>A0A5E4UER8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea morbifera|TrEMBL
MTQQNAEPAVRPAHPQDPACGTAPHANAPTSPARRHWLKGMSLAAGSLLVPVTATWVASP
PARAAGANLVEINDWIRIDADGTTVLGLSQCEVGQGAYTGLPQVLADELDADWRRVRVEF
VTARDAYRTAAANEALQQFVGASMSATLFYDRLRVAGAQAREALVAVGAKRLGVRTSNCV
TRDGRVIHPQSGRSIGYGELVADAAKQPLNPHPHLKNDAAHRLIGQSLARLDTPSKVDGS
AIFGIDVKVPDMLVGAVRMAPTSGGAPRSVRNRDAIKARKGVHDVVLAKDAVIVVADDYW
RAKTACDALDVEWKAGPAADSATILAERRAALVGGKAGVATDIGDATGVIAAGGKVVTSE
YHTPYIVHATMEPVNATVHVRKDKGEIEVWGPIQGQDKVRWALGGIFKLPPEKVTVHTTF
LGGSFGRKYVPDFVIHAAVASAAVGRPVKVIRSREDDIRHGFYRPCASARFQAALGSDGL
PVALHMRVAGQSLYNVIKKDHFEKAGYDETMLDGLYDLAYAVPNLRVEGVDVPQPNIPVS
FMRSVGSTSSVFFLESFIDEMAEVAGIDPVEYRKRMLRHDPLATRVIETTFASAGWQRKA
KPGVHRGFGYCTYTGRGTAFSTYVAVAVELRIVNDRFQIERVVCGVDCGRAINPNLIRAN
IEGGIGFALTNTFKSRITFADGGVAQSNFGDYPLLYLVEMPKIETVILPSDRPPQGCGEV
SLPPMAPAVAQAIRRATGVRARTMPLPQTVAEARALVHAGTPGATSVPGAV
>A0A6J5D5H8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia humisilvae|TrEMBL
MRNAPHSVERAFSRRDFLRAGLTVGIAASGGLLLGVSFNARSDGGAAPASVIAGDGSLQA
PPDQFAPNAFIRIDPDGTVALVVSKVEMGQGVYTAIPMLLAEELEVPLERVKLEHAPPDA
ALYADPLLGQQATGGSLSIRATWEPMRRAGAAARMLLIRAAAQAWQVEPASCVARNAVVT
HTASGRTLGYGELASRAAALPVDADLMKTVALKKPQAFTLIGTPHKRLDSPEKVNGVARF
GIDVREPGMRVAMVVNCPVIGGTLAHVDDRVALAQPGVRQIVKLDTAVAVVADHTWAAKR
GASALVIDWHEGANAALTSAMLFDDLRRASERQGVAARTDGDVDAGFKNAAQKVDAVYQQ
PFLAHATMEPMNCTVHVTADQCEVWLGTQVPTRIVDAAVKVTGLPPEKIIVHNFLIGGGF
GRRLEADVAAQAVAIGKQVDAPVKVMWSREEDIQHDMFRPCYYDRLSAGLDASGKPVAWT
HRIAGSSIVARWYPAWFKNGIDPDVIEVAASLPYAIHAQRIDYVRQEPRGVPTAFWRGVG
PTRGAFVVESFIDELALQAKADPVEYRRALLGQTPRARNVLEVAARAAGWGTALPKGKGR
GVAVMHAFGSFFCMIAEVDVKDGNVRVERIVCAVDCGHVVNPNTIEAQIEGGAIFGITAT
LWGEITLKDGRVEQTNFTDYRMMRINEAPRIETIIVRSGEDPGGIGEPGTSAVIPALTNA
IFAATGTRVRRLPVGDQLRAGQTA
>A0A7W8Q2F5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia atlantica|TrEMBL
MKLQINGKTYEVEADADTPLLWVIRDELGLTGTKYGCGIAQCGACSVLIDGAVVRSCVTP
VEGVAGRSITTIEAIENDEVGKRVVAAWVKHQVPQCGYCQSGQVMAATALHKQNPRPSDD
DIAAAMTNLCRCGTYNAIRAAVHEVAGGAPHTASSTAGVPGQLAAHPAGEPVAATTTIAL
ASIGAVSAPVRQGTVDEEQS
>A0A852VZZ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia antarctica|TrEMBL
MPAHSATAPERPASGDDRKNVSRRRFLGYLVAAPTLVVAAEIGRQTYFPGVPQANAAAIP
SPPLPAELYDLLDVIRDSARPTANLIRIEVNRDGTVSFALPRSDNGQGIITSTQMIIAEE
MNLDPDQVIVTLADARPELVFNQLTGGSTTTFSTYTPIRVAAALAQKRLLDAAANELRQD
VNVLRSRQGLITGNNGEQLPFGELTEMASSAVNEAVDVVLKDREEFTVIGTPRTKSDARA
MVTGKKKFLADLQIPDALPTVICRGPNINSAPQGVRNIDEVRNMPGVTDVEQVPTGVAVR
AKTFGQAVDAVNALRVDWDGGTVEGENDESVLAALRRGELPLAVPQVPGETVEGDFTFYF
RSNSALETNCAIADVRDGSAEIWGPSKSPIAAQAEIAKKLGIAQNAVTVHVTEGGGSFGR
RLFFDGLEEAAECSQAFGKPVKLMWTRSDDSRQGRTHPMATTRVRAQVSGESVSSFEIRH
TSVATEINPGLSEAITAAANKAPGGNYTISQSIYLTTQTNPYNVGAATSLLNEVDMRFNT
CSMRNIYSPDTATARELMIDQVAAKMGKDPYEFRSEFTKLTRWKNVVDRAAQEADWGKSM
PEGTAQGIAMHVEYKGVACAVVELDCRPETVNRKIRSARTGPRVTKVTYVVDVGLIINPR
GLEAQMMGGINDGIAMTLTSGLHLVDGHFVEASWDNYFYTRQWNTPPEMNIVLIEDSEAP
EPGGAGEFGVAATCGAIANAYARATGKVPTEFPILHNEPLPFEPYPTVPPVPPSPTNGLD
FVR
>A0A840BTX9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chelatococcus caeni|TrEMBL
MARLTINGTQRDIDVEPDTPLLWVLREQAGLTGTKYGCGVAQCGACTVHIDGVATRSCVM
PVSAIEPEQQIVTIEGLSPDGSHPVQKAWLALDVPQCGYCQAGMIMAAASLIAQNPSPTD
ADIDAEITNICRCGTYNRVRAAIKAAADGSATSNG
>A0A6J4UUI0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thermomicrobiales bacterium|TrEMBL
MAIALKVNGARHSVDVPPDTPLLWVIRDVVGLHGTKYGCGIAVCGACTVHVDGQAVRSCV
TAVGDVGDAEVVTIEGLHPTGDHPVQRAWRDANVPQCGFCQTGQIMQAAAFVATTRNPTD
QQVSEAMSGNICRCGCYQRIHAAVKAAGTGA
>A0A7W8TAP2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. MM5384-R2|TrEMBL
MLTRRTFLLGGASALGGLLVGWAVVPPRQRLMTSTPLPTQGTQVALNGWVKIDADNRVTI
MVPKAEMGQGIHTGLAMLLAEELDADWPQVKVEEAPIDRIYNAVQSIVDDLPFRPDDDSY
IRRGTVWITSKAVREIGTMMTGGSSSMNDLWTPMREAGASARVMLIAAAAERWDVPVREC
RAEKGYVLHPSGHKATFGELSSMAARQPLPRSVVLKQPADFRLIGQSVRRIEAASKIDGA
ARFGIDVLPDGLVYASVVMCPTLGGTVAHFDATPAQKIRGFIKAFAVPPYAGGTGGVAVI
ADNAFRAMSAVEAINVTWHDGAAAKVSSAAVDCRLVEALDHTDGHVYYHVGNVDNAMSRA
ARTIEAVYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQMPRLARHHAAKVLGLDVDLVD
VQTQLLGGAFGRRLELDFVAQAAAIAREADGRPVQTIWSRAQDFTHDFYRPACAARLQAG
FDEHGKLVAWHAKSAGQAIVPDALARYYGVPHIPIDKTTCEGAFDQPYEWPAARVSHKIV
ELPVPIGFWRSVGHSHQAFFTESFTDEAAAAAGQDPIAFRAMLLAQHPRHLAVLKRVEKL
SDWGRPLKPAADGARCARGVALHEAFGSVVAQVAEVSIGANRQIRVHRVVCVIDCGLPVN
PNLIRQQMEGGIVFGLSSALQNEITIVNGQVQQKNFVDFPVVRMNGCPAIEVDIMPSQLH
PQGVGEPGVPPIAPAVGNAVFALTGQRLRTLPLRLA
>A0A7W8T5R8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. MM5384-R2|TrEMBL
MMELIVNGVHHNVDADANMPLLWAVRDLLGLHGTKFGCGVGACGACTVHLDGVAVRSCVT
ALADVQGKPVTTIEGLGKGGDHPVQRAWKAANVPQCGYCQPGQIMQAASLLKQTPKPSDE
QIVEAMSGNVCRCGTYQRIKAAIKAAASEA
>A0A1J5Q2F7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MFGSDVSIPGMLMAVVARSPVFGGRVKAVNAGRTRAVEGVRAIVELESGVAVVAESVWSA
LRGREALEVNWDEGPQAAVGSAEISRRFARASARKGQTERDDGDVDAALRKAATVIEAIY
ETPYLAHATMEPMNCTALVEADGCDVWAPTQAQTEAQRIAADAAGLPPESVKIHTTLLGG
GFGRRLDPDFVEEAVRIAKVVGHPVQVLWTRDDDMRHDHYRPASHTRLRAGLDKRGAPLA
WFQRIVGPPLALDGVHLPYAIPNIREEHVMVDPGIPTGPWRSVGASQNAFVIESFVDELA
HAAASDPFTFRHKLLRRAPRHRAVLELAAEKAGWTTPLPQGRYRGIAAYHSFGSYVAQVA
EVPIKPAGAISVHRVVCAIDCGIAVIPDLVAAQMEGAIAFGLSAALKGEITIERGRVVQA
NFKDYPILTLPEMPQVEVHIIARQDEPGGVGEPGVPPIVPAVANAVFAATGRRIRHLPLR
SPEHGNS
>A0A1C3HAT9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia marcescens|TrEMBL
MAITRRTLLKGSALAVAAMLLPISTRSLAAVVSQDAAPPDGQYELNDWIWIDSGGRIVIG
VSQCEVGQGIYTGLAEVVAAEMDADWAQVTVKFVTGRDAYRQVAGGEAFAQFVAASTSMT
KFYQRTRLAGAQARDFFLRAGARHLALSPQQCRTEKGWVIEEGGQRKVAYGDLVRYAAEL
PLDPQPGLKSEAQEQESFIGKPLLRVDTPEKVDGSAIYGIDIDLPEMLIGVPWMVPDLSG
KLVAVRNERQIRAMPGVVDLVLTRQWSMNNMVGLDHDMSLNTVIVVASSYWQAKKAADLL
EVDWLPGAGQALTDSTIAAENLAMLDGDTLVPAVDRGEASALIHDAGQGSRLHEACYSAP
YVAHATLEPCNATSHYEEGRIEAWGPFQGQDMVRNVLAKMFGLKPADVVVNTTYLGGSFG
RKYLPDAVMHATAASRAVGKPVKVIYPREIDMRHEYYRPACISHYRALLDENGYPQALWA
RYAGQSLFWQMRRETVHEAGGWDESMVECVYSTPYRIPHLKVEAGIVEQPISLSYLRGVG
SVASLFFLESFISELSHKAKRDEYQYRRHLLQDTPEALRVLDATAAAAGWQHEPPPGVYR
GMSCNIWLGRNNAFTTYVGLVVEIAIQEGRLRVLRAVCAIDCGKVINPNLVRANVEGGIG
FALTTCLHSELHFERGGVVEGNFDRYPLLAIAEMPKVEVVVLDSARAPQGCGEVSTAVVA
PAMASALHKATGKTYRAMPFPREFSSV
>A0A238K1K4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Maliponia aquimaris|TrEMBL
MASIGKIARRTFLIGAAAIAGGAAFGAWYVTRPAPNPLKPGDGESALNAFVLIDGTGVTL
IAPRAEMGQGTMTTWAALIAEEMDLDWAQVRVIHGPPAQAYFNSALMGEGLTHKGYDASA
FQHSLGEMMGHLGKVFSMQVTGGSTAMKDGYERMRVTGAAAREMLKTAAAARLGVSIADL
RTEKGAVIAPDGTAIPYPDLAAEAAQVEPPRIELRRQEQWTLLGNSLPRLDIPAKSTGTA
QFSIDTRLPGMRYAAVRMAPTRGGMKSYDAFEANRMPGVEKVVDLGDGLAVIATNTWLAQ
QALDTIGVEWTPSAYPESTEAMFSAIEAAFDTEPDSVLRDDGNADRLPQGATRIEAEYRV
PFLAHATMEPMNATAWFDGTNLRLWCGNQGPTFLRDACAAEAGIAPEEVEVNVTLMGGGF
GRRGEFDYAVIATRVAKAMPGTPVNVTWSREEDMTHDFYRPAAIARITGAVADGAPVTFD
ARVASPSIAAQALKRWVGFSPGGPDKGIVDGIYNQPYRIPNYRVAGYRADIAPPLGFWRS
VGSSFNGFFHESFMDELAHAADADPLDFRLKQMRDEWLPGFYVLEAVRDMCGWTGTTPEG
TGRGVAMVYSFGTPCAVVIEVMQTEGGIRLTNAWMAADPGVALDPSIIEAQLTGGLAYGL
SAAIGEDITFAGGVVDQKNFPDYEPLRMSQMPAVEVSILEHQERLNGIGEVGTPPAAPAL
ANALFDLTGKRVRELPLRKAFDFYI
>H0TSS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MTDGTLGASKPPRGCLSVVRLAAADAETFIRITAAGEVTAYNGHVDLGTGIRTALGQIVA
EELDVSFARVVVVLGDTARVPNQGATIASETIQITAVPLRKAAAQARQFLLTRAAERLGI
ACDELSIEDGLIRGPNNRTLSYGELIEDETIRLELADDAPVKAASSYTLVGTSVPRVDLP
AKATGELTYVHDVRVPGMLHGRVIRPPYAGVDAGPFIGTSLLGIDRDSVRDIPGLVDVVV
IGDFVGVVAEREEHAALAAERLKIDWKPMPSLRNLDDVENALRANPSRPRKLLDKGDVEA
AISGAAKPMQRSYLWPYQMHGSIGPSCAVADCQPGQVRIYSGTQNPHILRSDLALLIDRP
EHEIEVIRLEAAGCYGRNCADDVTADALLLSRAVGRPVRVQLTREQEHLWEPKGTAQLMD
VNGGLNADGSVAAYDFATRYPSNGAPTLALLLTGRIAPEAIVWEMGDRTAIPPYDYDHMR
VTAHDMPPIVRASWLRGVSALPNTFAHESYIDELAAEAGVDPIAYRLRHLKDERARDLVN
AVAERAGWVPRAVRQEKTAENDVVRGRGFAYALYVHSKFPGYGAAWSAWIADVAVNTATG
DVSVTRVVAGQDSGLMINPDGVRHQIEGNVIQSTSRALMEEVPFARGKVAAREWGAYPII
TFPDVPKIDVLMLPRPDQPPLGVGESASVPSAAAIANAIYDATGVRFREPPFTPERVLQG
LRGAQAEAPPAKPLAPPVADKSRTAWIKPFAKRTGLAASVAAACSAAIGVAAALLPGRAI
APISRPDASVYSAATIARGEQLAALGNCAVCHTADGGIVNAGGRALETPFGTIFSTNITP
DVETGVGGWSYPAFERAMREGIHRDGRQLYPAFPYPHFAKTSDADLQALYAYLMAQAPVR
QQAPASELRFPFNLRPLVAGWNALFHDASPFKPDTAKSEQWNRGFYLVESLGHCSACHSP
RNALGAEQRQAYLAGGFAEGREAPALTSLSSAPIPWTEDELFTYLRTGQSRFHGVAAGPM
APIVNDLGRLPEADIRAMAIYLASFQDALPDAATLEAKAQHLETSTKVTSASSPAARLYL
GACAVCHEIGGLPLFGSRPSLSLNSNIHSAMPDNLIQVILHGITRPASPDLGYMPAFAEH
LSDTQVVELVAYLRSQFAPDKPAWHGIDSAVSRLRTAGQH
>A0A5P8Z3P8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax sp. THAF197b|TrEMBL
MNTQTRRQFLASSAGLVIGLTLPMKGRAQSGAAAVMTTGEAAEGTFAPNAFVRVAPDNTV
TFICKHIEFGQGPYTGLATLVAEEMDASWDQMRVESAPANNELYKNLFFGLQGTGGSTAM
ANSWMQMRQAGAAARAMLVAAAAEEWGVDASGITVAQGVLSHEASGQTATFGDLAEAAAR
QDVPVEPAVKNPSEFTYIGTDMPKVDSRAKSTGTATFTMDVYREGMEYVVVRHPDVMGAK
VASFDATEAEKVRGVTAVRQIPQGVAVYATSTAAAIKGRNALSVEWDMSEAETRSSAEIL
QTFRDAAQSPGLVVEETGDSASAIDGAETMHEAEFSFPYLAHATLEPMDAVLEVRDGAAE
IWMGAQFPGFDKGAVVQTLGLDAENVTMNVMYAGGSFGRRAQTIPQIGSEIAEIAKAAGG
DGAWKLIWTREDDMTGGFYRPMTVHKLRGGLDAEGNIVGWENRIVNQSIINGTMLDQGNP
EDPTSYEGSTKMPYDLPNLTVDWVKMETGVPVLWWRSVGHTHTAYATEVFLDELLEKAGK
DAVQGRLDLLKDDAGRDRAVLERVAEMAGWDGERVKGDRAYGVALHESFSTYCAMIAEVS
DDRGEPRVHKVWVAVDCGIAVNPNVIRAQIEGGLGYGLGSALFNTLTLGEGGVVEERNFD
TYRMLRITEMPEVEVAIIASDADPTGIGEPGTPPIAPAVANAWRALKGEAPRDLPMVS
>A0A7W3IW57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides ginsengisegetis|TrEMBL
MTVDARARTDQPDGPATDLEEDAHRISVRRRSFLGYVLGGATLVAAADLGLVDAAAAAPT
APQPAELYDLNDMLTDSCRPTANLITVTVHDDGTASFALPRMEVGQGITTSSAMLIAEEL
ELPVSKVKVTLAPARPELQFNQLTGGSNTTISTYTPIRVAAAVAKGALMDAAAIVLGDTV
ANLHARNGVVHAPDGSSVTYAELASKAASPTTRAVGVQLKDTSEFRVIGVGQGRVDALDA
VTGRKEFTTDKQVKGALPTMVCRAPTLNGTPKRLTNKAEIARMPGVRDLAKVDTGIAVRA
DTFGQCIDAIRAMKVEWNDGPVAGESDEDIVHELKAAELALPAPPDNPLAETLEADFLFY
FRSNSAMDTNSAIADVRADRATIWAGLKSPITAQQRIAEALGMTQDQVTVNVVTAGGSFG
RRLFFDGALEAAKISQAMGKPVKLMWHRADDARVGRGHPMSTNRVRITHAGDEVLAFQQT
HTSVETDYRHGLGEIISAMAADLPAGYGNLGYAETIFSLTQEVPYDFGVVSQTLTETDDR
FNTGSMRNIYSPDVRCASELVVDQLAKKLKKDPYEFRRSHLRNDRVAAVLDKVAKVGDWG
RSMPAGTAQGIAIHKEYKGASACLVEIDCRPATVDRDVPDATTGPRVTRVVFAIDAGLVI
NPRGMEAQMQGGINDGIALALTSSLHLRDGHFLEASWDNYFYTRQWNTPPEVKVILMPSD
SGQPGGAGEAGVAASFAAVACAFARATGELPTYFPINHRDPLRFRPKPVVPPIPQSPTNG
LKKTY
>A0A2R8AB03|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pontivivens insulae|TrEMBL
MQLRINGEIRTFDAEPDTPLLWVLRDILDIKGPKFGCGVAACGACTVLVDGQPVRSCSYP
VDGVEGEITTIEGISNGDTLHRVQEAWIEHQVPQCGYCQSGQILAAVALLGAVPEPTDED
IDLAMTNLCRCGTYPRIKAAIKTASGQGA
>A0A0F7M8L0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Spongiibacter sp. IMCC21906|TrEMBL
MFTIQVNGVDHTVDVPEDKPLLWVLRENIKLTGTKFGCGQALCGACTVHLDGQPTRSCVL
PISAVGQKRVDTIEIIGSDRVGELVQSAWRDMNIPQCGYCQSGQIMAATALLQNNSAPND
QDINEAMSGNICRCGTYKRIRRAIHKIADEQL
>A0A0F7LWT5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Spongiibacter sp. IMCC21906|TrEMBL
MAINFTLNGKKTQVEAAPDTPLLWVLRDELQMTGTKFGCGIAQCGACTVHFNGNAMRSCS
LPVQAVEGQAITTIEGEDSAEAKALQAAWDDLAVYQCGYCQSGQLMSASKLLKDKPSPSD
DDIDQFMSGNICRCSTYQRIRAGIKQAASDLATEVTS
>A0A0K8NUE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MQRRRFLEAGSAWLIGVPARTAGAGQAAGPLRATDDTAGGGKTLAKDRLAAWLEIGPDGR
VTAYTGKVDLGTGVRTALAQMVAEELDLPIDRIEMVMGDTALTVDQGQTASSVSISSNRV
LRQAAACARAALVEAAARQLELPPQALRVVDGVVMTADGTRRLSYGDLVRAQPLPAALLL
DPAITLKPAAGYQVVGRPVARVDIPAKVFGRFTYMHDFSLPGMLHARVLRPPGMGATLRG
IDASALSALPGFVQVVRKASFVAVVCRDEWSAVKAARALRLDWVQADTLPEQARLYAYWR
QLPVAKTEPPVRWGDAIQALAGAARRLAATYDFGPHTHGSIGPACAVADVRDGRCTVWSA
SQATHSLQTELAAVTGLPRDRVRLIYLDGSGCYGRNGHEDCSADAALVSQLAGAPVRVQW
MRADEHGWDPKSPPTLIDMEGGLDADGRAVAWRSEFFLAQSTGALSDFPLLAAVHGGQQR
TGYLTGSIAKNAEVLYDFPNVLTRVHRVRDQAFRTSHLRSPGRMQNTFANEAFVDEMAAA
AGEDPARWRRRYLSDPRAHHVLQDVMRLARWRERPSRAGRHARGSSARGRGIAQVRYEND
RTYVAMVVDVEVMLRTGAVRVTDVWCSHDCGQVINPDGVRNQIEGGIVQTISRTLVEELQ
FDRGHVTSLDWASYPILRFSQVPRIHVSLVDRPDEPPWGAGEMAPTLVSACISNAIFDAT
GARLRSVPFLPAKVLQALGERGRVAAVRAS
>A9IS86|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)|TrEMBL
MHPLVRSHAAAIPAVRNVSRRRFMQGAGGLVLGIALAPAATRAATGAAATAGDGAFAPNA
FVRIGTDGSVTVLSKHLEMGQGAYTGLATLVAEELDADWASVRVEGAPANTDLYKNLALG
LQGTGGSTAIANSYEQMRRAGATARAMLVAAAARQWQVDAKDITVSAGVVRHAATQRQAG
FGDLAAAAAKLPVPESVPLKAAADFRLIGKEAPRRVDGLAKTDGTAIFTQDMKLPGMLVA
MAAHPPRFGGKVASFDASKARAVPGVRHVVQFSGTGHNFEGVAVLADNTWAARTGRDALQ
VQWDDSQAYRKGSDEIRAQYRAALDLPGAVAASHGDAEAALAQSAKVIEAEYEVPYLAHA
AMEPMNCLVRLGDDRCDIWNGEQFQTVDQAVVAKVLGLAPEQVFINQLYAGGSFGRRATP
HADYIAEAALIAKAARDQGVRAPIKLVWTREDDMRGGYYRPLNVHRARIGLDADGKLQAW
HVRLAGQSIFLGSPFEGAMQNGIDPTSVEGQADLRYSVPNLHVESYTPQDVGVPVLWYRS
VGHTHTAFSAESLIDEAAAAAGQDPVAYRIALLDQHPRHRKVLELAAERAGWSQPLAAGA
QGLRRGRGVALHESFNTIVAQVAEVTVQADGSFKVDRIVCALDCGVVVNPDVVRAQMEGG
IGFGLSTALHGALTLKDGVVEQSNFHDYAVLRINEMPAIEVHTVASTAKPTGVGEPGVPP
VAPAVANALYAATGQRIRTLPFAAQLKPLAKQA
>A0A099Y1T0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polaribacter sp. Hel1_85|TrEMBL
MKFQNKNNFSRRNFLKTSVLAGGGMLIGFNLLTACKPDAEMPVDIENLNFNDFNAFIKIS
DEGYVTIFSPNPEIGQGVKTSMPMIIAEELNVEWSKVNVVQGVLDTKNYKRQLAGGSQSI
RFGWDALRQTGATTKQMLVNAAAIKWNVNANTCKASKGIITNSNGDKLGYGEVVKEAALL
EVPEDVKLKKVSEYTIIGQEIVNVDIDKIITGKPLFGLDYKAEGMLYASVLRPPSFGQKL
ESFDATKAKKVAGVIDVITIGDKVRNFVKAGKNNWTFKLSETDKVVVIATNTWAALKGKK
ALSAVWVTDTKLESTQDHDKILTKVLDGKKQNIRREDGDVHKAFSKADRVIEKTYHSPFL
PHNCMEPMNFYANVTAEKVHLVGPVQTPEYAASVVADMLGYDIDKVSLEMTRMGGGFGRR
LYGDFVYEAAEISNAIKKPVKVISSREDDMTTGIYRPSIKYRIKASIKDGKVTGYHLKEA
AVGGNMYGLIPNFFPAGCIPNYKVETGNYRGNITTGAWRAPYTNFLAFAEQSFFDELATE
LNIDTIQLRLDLLQNVKGTSDKSIQYSGQRMEDTIKLVREKANWGKTKDGVYQGFSAYYS
HNTHVAEIAEIELKDGFPVIKKVVVAVDCGVVVNPTGARNQVEGGVLDGIGHAMYADFSF
KDGKPSDRNFDTYRLIRMQETPKVEVHFVENELSPTGLGEPGLPPAGGAVANAINAALGK
RMYSQPFVKELNDSSILS
>A9I9K2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)|TrEMBL
MASLTINGNSQDVDAPDDMPLLWVIRDRLGMTGTKFGCGMAMCGACTVHLDGAPIRSCVT
PISAAAGKQITTIEAVGEDDVGRAVQQAWTEIGVPQCGYCQSGQIMSATALIKSNPAPTD
ADIDAAMSGNICRCGTYPRIRAAIKQAAAAKGAAK
>A0A7W8K1F9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. K2C7|TrEMBL
MHNIIVNGQPLAADVDPQTPLLWVLREVAQLTGTKFGCGIGLCGACTVHVDGRAVRSCIT
PVASVEACAITTIEGLSPDGKHPLQQAWIAAQAPQCGYCQPGQIMQAATLLRDYPQPTDA
NIDAVMSGNLCRCMAYVRIRKAIKLAAASGQEMPPHA
>A0A7W5HL66|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas stenophila|TrEMBL
MHVLANRDNDKAPAAQPRLVHVSRRGFMKGTAGLALGLYMAPLLGRGGRALAADENGEFA
PNAFLRVTPDGEVVVIAKHLEMGQGTYTGLATLVAEELDADWASVRVEGAPADPQRYQNL
MFGIQGTGGSTSIANAFEQMRRAGATARAMLVTAAAERLEVSPASLSVREGKVIHEASGR
ELGFAELAEAAAGLPVPDEVTLKSPGQFTLIGKQHLPRQDGPAKTDGSARFTQDVQLDGM
LIAVPAHPPRFGSRLASVDDAEALKVPGVVASVRFSSPTRDGDLVAVLASNTWAAIQGRD
ALSLEWDDAQAFTLSSDEIEAAYRERAGTPGEPVTRRGDAAKALETAAQVIEADYVVPYL
AHAAMEPLNCVVDLQHDHCTIHNGEQWQTMDQQLVGKLLGLAPEKITIHQLYAGGSFGRR
ANPVSDYVLEAAAIAKAARAQGRDVPIKMVWTREDDTRGGHYRPLNVHRARLGLDDDGKL
TAWHQRLVGQSIMAGTPMESMMVEDGIDPTSVEGASNLPYAVPALHVELHTPRDIGVPVQ
WWRSVGHTHTAFSTESLIDEAAVAAGQDPYRYRRELLADQPRWRGVLDLAAEQAGWTSPL
EPGTEGVRRGRGIAVHKSFSSYVAQVAEVSVDADNALRVNRVVCAVDCGLAVNPDMIRAQ
MEGGIGFALAAALHSEITLDGGRVVQSNFNDFQVLRLDEMPEIEVHIVASEAAPTGVGEP
GVPPLAAAVTNAIHAATGQRIRRLPIADQLEA
>A0A3G7C3H8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MNKPIDSAKELLSLALDEPVNLSRRRFLTGTAVGALVLGFGLPLGSARVLAATATAAERG
TQVPAFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFVVESAPPGEAYVV
MENGLRITGGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPVAELSTEPGRVLHATSG
RSLGYGELAGRALDMPVPDPTSITLRDPSQFRWIGKPVRRVDAYEKSTGKALYSIDLKVD
GMLHAAVQHAPRLGMTVGSLRNEAQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEAIQ
VDWLEASADSKVRTMPADFSSDGFRDFLAAQQGPARDDENEGDVAAALASAKTQVEATYH
NQYLNHAQLEPPSALARFNPDGSLEVWLPNQAPDMFRDDIARRTGLSASQITLHSPLLGG
FFGRHFLYDSANPYPQAIALAKAVGRPVKLIWSREEEFVRDVLRPVAVVKFRAALDAEGL
PVAIEAVSATEGPTEAIAGKQGEKIDPTAVEGLSGKSYAIANKRIAQIYVKGPAMLGYWR
SVGNSLNDFFYEAFLDELADKGGRDPYELRQHLLRDNPRLTTLLQAVGELSGGWKRGPFT
AEDGSRRARGVAMASPFGSHTAVIAEVSIESGQVKVHDIWQAIDPGSIVNPAIVEAQVNG
AVALGLSQTLLEEAVYVDGKPRARNYDLYPILPLSRMARVHVRIVESGEKMGGIGEPPLP
AVAPAVANAVARLTGQRIRSLPLSRYTFS
>A0A3G7EU40|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MTFILNGRRLLLDQLPPNTPLLYALRNDFGLNGPKYGCGLGQCGACTVLVDGVAARSCTL
PLSSVQGKQVTTLEGLKQEERLHPVQQAFIDEQAAQCGYCSNGMIMTLVALFEREPEADE
QRIKNELAYNLCRCGAHFEILQAAARARQLLAERGRP
>B3R2V9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLAMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARVTTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A5E7ZX01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. EC-HK134|TrEMBL
MLLTVNGKSHDVDLPSDMPLLWVLRDGLNVTSVKYGCGIALCGACTVHIGGDAVRSCQVS
LGDVWADVTTIEGLGRPGALHAVQVAWIAHQVAQCGYCQSGQIMQAADLLARNPEPSDDD
IDAAMSGNLCRCGTYPRIRAAVHAAASAMREV
>A0A7X6J4M2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MTESNRNLVPEDEFPTGSPVNISRRRFLLASAGAATGAFVLGFGVPIGTARAQQAAGPMP
PGTRVPAFLEIRPDNTVRFMSPFAEGGQGVFTAMAQIVGEELDVDPKMFVVENAPTGNDY
LVVHGKMRITGGSMSVRTSYETMRKLGALARNMILQAAAKRLDAPIGELTTEPGWVIHAA
SGRSLAYGEVATEALDLPVPDPASVVLRDPSQFRWIGKPVERLDVYDKSTGKAVYAMDCK
VDGMLHAAVQHAPRLGLIVGRIRNEDQLRAMPGVHSVHNLQGAVGVVAERWWNAKRAAEA
AQVDWKEPGPDADPAFRQMPADFSTAAFSDRLANEPGTGKDAENVGDTPGTLSSAKTVVS
ATYKSQYVHHAQLEPPSTLARFNPDGTLEVWMPNQAPEQFQADIAKLTGLDASKITVHSP
LLGGFFGRHFLYPSANPYPQAIQLAKTVGRPVKLIWSREEEFLRDPLRPMAAVRFRGALD
ASGMPVALEAISACEGPTEGVFGHKEDSLDPTALEGLTGKSYAIPNYRIAQIYVKNPTML
AYWRSVGNSMNDFFYETFLDELADKGGQDPYELRLKLLQKNERLSNLLKAVGDLSGGWKR
GPFTAEDGSRRARGLAMASPFGSHTAAIAEVSIRNGQVVVHDVWEAIDPGSIVNPAIIEA
QINSATALGLSQVLMEEAVYKNGEPVARNYDLYPILPPDRMARVHVRIIESGAEMGGIGE
PGLPAIPPAVANAVSTLTGKRIRSMPLSNYTFES
>B4EFG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)|TrEMBL
MDLDVNHQRVNVDCDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHLDGTAVRSCVLP
VAAVAGKRITTIEGLAESPEKRHALQQAWVDEQVPQCGYCQSGMLMAAADLLTRQPDPTD
ADIDTAITNLCRCGTYPRVRIAIKRAAKVLRDGHA
>A0A7W6HCW6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantimonas endophytica|TrEMBL
MVTFTLNGQEKTFDGDPDTPLLWVIRDAERLTGTKYGCGIAQCGACTVHLDGMTLRSCVT
PISTVDGSSVTTIEGLEGPEAEAVQAAWRAIDVPQCGYCQSGQIMSAVSLLQFNPKPTDE
DIDGAMTGNICRCATYVRIRQAIHDAADTLEG
>A0A7W4VBI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus alkaliphilus|TrEMBL
MRIRGIEALAGGQAGNSGEARADAGVATLDRRGFLKLTGLAGGGLALGVAPLAQAQEGGK
PKAPPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVVT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKSFGADKARAVPGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSKVSSQALFDEYAKLAGQPGTVARAGEGDIAAAIQRAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHRARVG
LDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDENKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNPLSAE
AQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSQDNPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>Q0KB36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)|TrEMBL
MPDHQISVNGKSVEVRSDGCTPLLWVLRCELKLTGTKFGCGVGVCGACAVHVNGKMVLSC
QHQASEMEGKKIVTIEGLDGPEASALRAAWLKHEVVQCGYCQSAQLMAASALLKRTPNPK
ETEIADQMSCVICRCGTYTRIRRAIAEAAEMLRG
>H0S8A6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MTDSVAKTADHPRGVLTVERSIADSSSETFVQITASGEVSAFNGHVDLGTGIRTALGQIV
AEELDVSFARVVVVLGDTAVVPNQGATIASETIQITAVPLRKAAAQARAFLLARAATQLS
LTVEDLTVEDGLVRGPNNRVLSYGELIGDEAIRLELAEDVAVKSADNYQVVGRSVPRVDL
PAKATGELTYVHDVRVPGMLHGRVVRPPYVGVDAGPFIGTSLIGIDKDSVRDVPGLIDVV
VIGDFVGVVAEREEQAILAAERLTVNWKPVPTLRDLDDVENALRANPSEPRRLLDKGDVD
TAIAGAAKPMRRTYLWPYQMHGSIGPSCAVADVRDSHIRIYSGTQNPHLLRADLARLIDC
SEHQIELIRLEAAGCYGRNCADDVTADALLLSRAVGRPVRVQLTREQEHVWEPKGTAQLM
DVNGGLNADGSVAAYEFATRYPSNGAPTLALLLTGRIAPEPAVFEMGDRTAIPPYDYDHM
RVTAHDMPPIVRASWIRGVSALPNTFAHESYIDELAAEAEVDPIQYRLRYLKDERARDLV
NAVAERAGWTPRPVREEKTPVDGVVHGRGFAYALYVHSKFPGYGAAWSAWIADVAVNTTT
GDVSVTRVIAGQDSGLMINPDGVRHQIEGNVIQSTSRALMEEVPFSRGKVAAREWGAYPI
ITFPDVPKIDVLMLPRPDQPPLGVGESASVPSAAAIANAIYDATGVRFREPPFTPERILR
GLRGDQIEPVNPQPLPAPEKPAATWLKPFAKRSGVVASAVAACAAAIGVATAVLPWRAIA
PITRPDPSVYSTATIARGEALAALGNCAVCHTADGGLINAGSRALKTPFGTIFSTNITPD
VETGIGAWSYPAFERAMREGVHRDGRQLYPAFPYTHFARTSDADLQALYAYLMAQQPVRQ
QAPDNQLRFPFNLRPLVAGWKALFHSTEAFKPDPTQSEQWNRGFYLVESLGHCSGCHSPR
NTLGAERRNTYLAGGSADGWEAPALTALSSAPIPWTEDELATYLRTGQSRFHGVAAGPMA
PIVKDLATLPEADIRAMATYLVSFQAPSPEQAKLEAMAADLEARTRVRSASSPAARFYLG
ACAVCHEVGGLPLFGSRPSLALNSNLHSATPDNLIQVILHGIMKPASSDLGYMPAFKDHL
SDEQLAGLVSYLRGQFAPDKPAWTNVDAAVSRIRSATHR
>B7RRN8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter sp. (strain GAI101)|TrEMBL
MTITQSRRNFLASSLGLVIAVSLPMRGRAQSGAALAFQPDGSTPTFAPNAFIRVAEDDTV
TVIIKHIEFGQGPFTGLSTLVAEEMDADWGQMRAESAPADDEKYKNLLFGLQGTGGSTAM
ANSYTQMRKAGAAARAMLVQAAAEEWGVDASTISIAKGVLTSGSNTSTFGPLAAKAALLT
PPEDPAVKDPKDFVLIGKDRPKLDSKAKSNGTAVFTMDMDLQDMEYVVIRHAPMLGGTVA
SFDDTEAMKVTGVTAVRQIPQGIAVYATSTYAALSGRNALTVEWDDSAAETRTSAQIMDD
FAKLATSGEMKNAEENGDIDATLSEAAQVIEMEFRFPYLAHAPMEPLDAVIQVKDGSAET
WGGFQFPGFDKQAVAGNLGLPVENVKLNVMLAGGSFGRRAQPSAQIGNEIGAIAKAAGRD
GAWKLIWTREDDLAGGYYRPMTVHKMRGALDADGNILGWHDIVVNQSIMAGGPMEQMMQD
GKDPTSYEGATKMPYDLANLRVDWVRAESVVPVLWWRSVGHTHTGYATEVFLDQLLEAGG
KDPVQGRLDLLKDDMGRDRAVLERVAKMAGWDGTKVKGDKGYGVALHESFGTYVAQVAEV
EDRNGFPHVTKVWCAVDCGVAVNPNVIRAQIEGGIGYGLGSVLFNAVTLGEGGVVQEQNF
DTYRMIRINEMPAVEVEIIESTMDPTGIGEPGTPPVGPAVANAWRALTGTNVTTLPFMTP
AGA
>A0A7W5A3K5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides albus|TrEMBL
MPEQTFILNGEPVTVDVEDDVRLLWVLRDILGVKGPKYGCGINVCKACTSHINGKAFNPC
AVPVGKLDAKDEITTIEGLPGEVPESKRGEHGLHPMQESWLDKDVAQCGYCQPGQIMAAV
ALVKKVRAEGRTITDADLDGIRNICRCGTYTRIREAIREGEQRM
>A0A375E4H3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLEMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGADHVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A375E7E7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSHPDTSRRRFLQAAGAMPAALVLGFHLPLAKAADAGTPARDPDDVNAWLRIDADGSVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQGWNVPVAQCRAVQGMVRHEPSGRALGYGALAARAATLRR
PASVALKDPRDWTLLGRPTDRLDIPLKTRGAAVFGVDVRVPRMLVGSVMACPAFGGTLRR
VDARPALAVRGVRRVVPLDDAVVVLADSYWTARKGLAALQPDWQLPQGNLASDAALMAGY
RDAARSASSMALRHGDPDTQMQGAPAYTAEYEVPYLAHATMEPMNATADVRADRAEIWGP
TQVCGEIAQRLSGVLGLPADRIAVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDVQHDFYRPAAAARFSAVLAPDAAGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYVLPHVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAKADPLQFR
LNLLADRPRPARLLQRLARHVGWGSAPAGRFHGVALSQAWGSLCATVVELSVQGQRITLH
RIVNAIDCGTVINPATVERQLEGASIWGLSAAMTGAITIADGRVQQSNFHDYPLLRLAQT
PRFEAVLAASGERIGGVGESAVPTLAPALANALFAATGQRLRSLPLARHGFELA
>A0A375BUE5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEARADAGVATLDRRSFLKLTGLAGGGLALGVAPLGQAQEGGK
PKAPPAAPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPAFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQKWKVDPASCRVEQGVVT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKSFGADKARAVPGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSKVSSQALFDEYSKLAAQPGTVARAGEGDIAAAINGAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQSVRVWVGSQFQTVDQAAVARTLGLAPDKVVLTTMMA
GGGFGRRAVPTADYIVEAANVLKAWVAAGHSEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYGLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEIAAAAKQDPVAFRLARLDEKKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNPMSAE
AQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSQDNPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A375J432|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLENVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAARRLGVDAARLEAADGVLRVPGTQLSIGYAALV
AGEHVELPLAEDVPTKPVDAYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLDIDRESVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
KPVPPLPALDDPEPALRANPATRRELLSEGELPAGGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGTLLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPSIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDQRAADLLRAVADAAGWQRGAAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVVLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMSGQG
>A0A2X4ULU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia plymuthica|TrEMBL
MTISQVPLTRRRFIVGAGALVIGAYLPSTGALARTTPATAPESNAFEANAFVQIGEDGIV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDTSVYKNLSFGFQGTGGSSSV
ANAYDQMRRMGAMARALLVQAAAQSWKTSAQEITVQAGKISHAASGREAGFGEFAALAAK
LPPPDPAGLTLKDPANFTLIGKVSGLHRVDSLAKTNGSAQFTQDIHEPDMLTVTLKKSPR
FGGKVASFDASRALQVPGVVDVKQTDTGVAVYAKNTWAAIQGREKLQVEWDDSQAERRNT
EQIFAEFRQVAQKTGVVATSRGKSDEVFDKADKVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDHKQLCDLFQLPPEKVQIETILAGGSFGRRIDLGNPALGPDLAADM
AAAAKAIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVGWTDTVVGHSWTLN
SAMTALVVNGVDQMMIEGASELPYTFESFRCDAHIVPGKVPTSSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPREAGVLRAVAKAANWQGAKVVDGRARGVGVAKAFDT
RVAQIAEVSIGEGGIPRVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSIALYGNITLKD
GLVEQSNFNNFRPLRIDEMPEIEVIIVPSTEKPTGVGELGVPTIGPAVGNALALLGRPRT
SLSLPLHRPNSDASVLPRKTS
>A0A4P8HLE1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MAPPNSSRRLFLKAGAAATGGLLLQVAIPGALARALPAGTAFSPNAFIRIGADGKVMLTM
PYVEMGQGTYTSIPMLIAEELEIDLAQIVLEHAPADAAKYANPALGGQMTGGSTTMRAAW
MPMRQAGAAARILLVRAAANQWRVDPASCSAERGAVIHAASGRRLRYGQLAEAAGRLPAP
AGKDIVLKEPGRFRLIGTAAKRLDTAAKLDGSARYGIDVVVPGMKVAALAISPVAGGRVA
SLDQAAALKIRGVRQVVRLDDCAAVVADNMGAANKGIAALALQWEDGPSAALTTAAIVAD
MAQASQGAGAQVRSENDPEGALRGAARVLEAIYELPFLAHAPMEPVNCTVHVRADGCDVW
TGTQIMGAAHAVAAHAAGLPLERVTVHNFLLGGAFGRRLEVDMIERAVRIGKEVPHPVKV
IWSREQDIQHDMFRPYFYDRLRAGLDAAGKPLAWTHHITGSSVLGRFMPAAFNNGFDSET
VDGADAPPYAFPAIGVSYVRHEPQGVATAFWRGVGPAHNVFVVESFIDELADAAGTDPLR
YRLDLLGHNPRARKVLELAAEKAGWEGPSAGKAGRGLAVQFAFGTYMAMVADVVAGPEGE
LRVVRVVCALDCGVVINPDTVRAQVESAVVFGVSAALYGDVTIKDGRVEQSNFHDYRVLR
MHEAPVVETHIVPSGETPGGMGEPGTACVMPAVANAVHALAGKRIRKMPIGATLPART
>A0A4P8HYD8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MPTLNINGTDTALDVPDDMPILWALRDVAGLTGTKFGCGVALCGACTVHLDGQAIRSCVT
PVSAAAGKKIVTIEAIGNDPVGAKVQDAWRKIDVVQCGYCQSGQVMAATALLAATPKPSD
ADIDNAMSGNICRCGTYGRIRTAIKIAAGTVVVKAAVK
>A4A7F1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Congregibacter litoralis KT71|TrEMBL
MGKWTRRAFITTGVLAGGALAVGVAIRPGHRAPKVAGEVTEDGEVLVSMWVKIDPSNKIT
LIAPHSEMGQGAQNALTQMLADEIDARWEDTAFMEAPAIDEYANWALGKGYLIGDADIPE
VLVPTIDGAMLQVAKAMKMQITGGSLSIRTTGVYGVRAAGAAARELLINAASEAWGVPAS
QLDARDTHIVDTTTGKRAPFAEFALAASQTAPSASPTLKTPDQFRIMGKSAPRRDIPAKV
DGTAVFGIDAQVPGMKHAAIMAAPVFGAQLVFVDARKAESMAGVSQVVSLEDAVAVVADG
YWQASEALKTLKVQWSQTDYDDASSESLFQQFDQDLARGIEGGSSKADVDDGDVEGALAS
AAATLDSTYRVPYLAHACMEPMNATARVTDDSCEVWIGTQNPLGFRYEVADALDMDVEQV
QIHQHPMGGGFGRRSNSDTAVQAARIARAAGEPVKLIWSREEDVRHDHYRPAVASRFRAA
LDDGGNISAWENVYHEKHEPVEAPTIPYTVGAQKIHHVESPTHVPFGPWRSVDHSQHGFF
TEAFFDEVAVAAGKDPYEYRMALLRDRPRHQKVLQTAAEQAGWGETLPKGRGRGISLQES
FGSLVAQVVDVTVSDGAISVDRVVVAVDAGFAVSPDGLTAQMESGVNYGLTAALYGEITI
EDGAVKQSNFHDYPMVRMGDSPLIETYIINSGEAWGGAGEPGTPGIAPALVNAVFDATGL
RVRELPLSKQDFSDFS
>A0A7W6XF65|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR48|TrEMBL
MNFIDNPGKLHSFEKRGFEKNIKVEKVSRRSILKGLGITGGFVLAAPVMSRQALAYETGA
GKMPHGVVVDPRVFVSVGPDGIVTIVGHRSEMGTGVRTSLPLIVAEEMEADWSRVKVQQA
HGDEVKFGNQDTDGSRSTRHYLIPMRQIGASARTMLEQAAAKRWGVPAIEVKAVNHEVVH
SASGRKLGFGELAADAAKESVPSIEGLKLKDPKNFRYLGKGQVGIVDLHDITTGKAHYGA
DVRLPGMKYAVIARPPVTGGKLVSFDPDAALKVPGVEKVLKVQGWPWPSKFQPLGGVAVI
ARNTGAAIKGRDALKLVWDDGPNGKYDSVAYRKELEEASRKPGLVLRKEGDADAALKGAD
KVIVGEYYVPHLAHVSMETPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLGIPEGNVTV
NVTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDIHNGFLHTVSVERIEAGLD
KSGKVVAWRHRSVAPSIASTFAAGTVHQAPFEIGMGLVDMPFEIANISCENPEAAAFTRI
GWFRSVSNIPRAFAVQSMVGEIAQATGRDQKETLLALIGSPRIVKPEVKDLWNYGEPQES
YPIDTARLRKVVELVAEKGEWGRKVPKGHGLGIAVHRSFVSYIATIVEVAVDDKGKLTVP
RVDTAIDCGTYVNPERIASQIEGAAIMGLSLAKYGEITFKDGKVQQKNFDDFQVVRMDES
PVVTNVYIVPPGPDTPPSGVGEPGVPPFAPALINAIFAATGKRIRSLPIGKQLEA
>A0A839F5A7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dokdonella fugitiva|TrEMBL
MTARVDAGRRRFLAISLTAAGALVVGIRRANAAPTPGVPPELLGDDLTDLGPFVRIERDN
RIVIGARGCEIGQGVITSLPMLVAEELDVDWAQVRVVQLPYGYIDTDQGPSNRYGDQGAG
GSTSVSDGWKDLREAGATARWLLVQAAAKEWGLPAEQLRTEAGEVLAPDGRKLSYGALAR
SAAAIAPPDQPVALKRPEQFRIIGKPTRVVDAREIVTGRSRFGIDEYAADALVAVILRCP
YLDGALESFDDAETRKVAGVVDVVAIAGPKPGEPFDGPLASGVAVLAEHTWAALRGRELL
KVQWKQGPWSGESSGALAARANELLDRNEGGTGVRHDGDYAKARKQARNVVEARYEVPFL
AHATMEPPGALIEIKQDSARLVASLQSPGGASEMIARMTGLARKDIEVRMTRAGGGFGRR
LENDFVAEAVLVAKAAGKPVKLMWTREDDLQHDFYRPFGVHALSATLDRRKQVSGWTHRC
AATPRPYREGGGRKRPINTGCLEADDFPAGLVANLDKTFFAVESGMPRGWWRAPLHTFHA
FAVQSFIDEIAIASKQDAVKLRLAMLGEPRKIPYSGHGGPQFDTGRLAEVLRRCAAKIGW
GERRDDGHGIGIACHFTFGGYTAHAFEVSIEGRELRIHRAVCVVDVGRAVNPLGVEAQMM
GGTIDGLSTALHLAITVKEGQVQQHNFPDYPLLRMAQAPRGVEVEIVASDADPVGAGEMG
VPSVAPALANAVYAATTVRVRKLPLMPELMRML
>A0A2X2IED4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MEIKINGRMVALDDVSPETPLLYVLRNDLGLNGPKYGCGLGECGACTVLVDGVAARSCSI
PLSGALNKSITTLEGLGETGRLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFERNPQADE
QQIKNELAYNLCRCGTHIEILRAAAKARQLLAERGQA
>A0A0N1FZM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinobacteria bacterium OK006|TrEMBL
MPSYSFVLNGKPVTVEAPADMPLLWVLRDLLHVTGPKYGCGVGVCRACTSHLDGAEIQPC
VVPVADCVGRGVTTIEGLADGDTLHPVQQAWLDCDVAQCGFCQPGQIMAAAALLKKTSRP
TDDDIDRIENVCRCGTYSRIREAIKKAADADGQVTRPGRSHP
>A0A1Y6KCZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MNAFLKTDLSAALPLISAQGVTNLSRRRLLGLGVGAFVLGTLLPALRAEAQSAGSVKPGT
RVPAFLVIGKDNTIKLLSPFVEGGQGINTGLAQIVGEELDVDPSRFEVECAPPGPDYAII
NGLRLTGGSFSTRSSYEVMRKLGASAREMLIRAAAAKLNVKPDTLTTEDGQVVHAASNRR
VSYGEVAEQALALTPADNVALRDPATFRYIRQPMARLDVRAKSTGKAVYAIDQKVDGMLY
AAIQHAPVLGTEPERIGNEAAVKAMPGVDAVHRLPGAVAVTADSWYRARKAVEALDVAWS
KAPASGFDAVAADYSSAGLLAALKASDASGVSAEKDGDVATAFAGAATIVEAEYDAPYLA
HGQLEPPSSMARLNPDGSLELWVPNQMPELFQGIAAKLAGIAPDKVILHSPMLGGFFGRH
FAYGSSNPFQQAILLAKATQRPVKVLWSREEEFKMDALRPLSFSRFKAALDKDGKPTAIQ
VRTVGEGPMGRWFGVTAGGKVDSSAVEGIVEKPYAIPHRSMEYAKFAHPVTIAFWRSVGH
SMNDYFYEGFLDEIADAGKQDPYQLRLALLKDRPRHLKLLETVAKMSGGWKRGPYEADGG
KRARGVALASPFGSETATIAEVSLKQSEVQVHNLWIAFDPGSIVNPAIVKSQVESAAALG
LSAALFEELVYKDGVRQSHNFDDYPILSRSAMPKVTVEIIESGAPMGGVGEPGLPGIAPA
VVNAVAALTGRHVRSLPLAKAKLGV
>A0A1Y6KAZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MTIIANPDIAKSTSRRGFERHLKVENVSRRAILQTLGLAGGFVLAAPLLSRPAFAAYETG
AGKMPHGTVVDPKIFVSIAPDGIVSILAHRSEMGTGVRTSLPLIVAEEMEADWSKVRVVQ
APGDEVKFGNQDTDGSRSTRHYLLPMRQIGAMARAMLEAAAAKKLGVPASEVKAVNHEVV
HSASGKRLGFGELAADAANQPVPAVDTITLKSPKDFRYLGKGQVSIVDLHDITVGKAHYG
ADVRLPGMKYAVIARPPVTGGKVKSFDSAEALKVSGVEKVLEVKGWPWPSKFQPLGGVAV
IARNTGAAIKGRDALKVEWDDGPNAAYDSVAYRAELEAAARQPGLVVRQEGDADAALKSA
DKVITGEYYLPHFAHVSMEPPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLQIPIENVT
VNVTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTRDDDIQHDFLHTVSVERIEAGL
DKSGKVVAWRHRSVAPTILSTFAAGADHAAPFELGMGLVDMPFEIANIQCENPAAKAMTR
IGWFRSVSNIPRAFAVQSMVGEIAAATGRDQKEMLLELIGSPRVVKLTSVKDLWNYGEPY
ESYPIDTGRLRRVVEFVAEKGNWGRSVPKGHGLGIAAHRSFVSYIATIVEVSVDEGKLTV
HQVDSAIDCGVFVNPERITSQLEGAAIMGLSLAKYGEVSFKNGRVQQHNFDDHPVVRIDE
APLITNVHIVPVDADTPPSGVGEPGVPPFAPALANAIFAATGKRLRALPIGKQLAI
>A0A6M4H8T4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter palustris|TrEMBL
MVQLNVNGKSYKLDIEDDMPLLWALRDELKFAGTKFGCGVAQCGACTVHVDGEAVRSCVM
PVSAVAGKKIVTIEGLSKPGIHKVQKAWIEHDVPQCGYCQTGMIMAAAALLAKKPKPTDA
DIDDAMSNLCRCGTYARVREAIHAVAENKPAPVKA
>A0A1Q8JEN6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae356_Ps1|TrEMBL
MSFAMPRSDNGQGIITSTQMIIAEEMDLDPDQVIVTLADARPELVFNQLTAGSSTTFTTF
AAFRVAAALAKGRLLDAAAAELGQDKAVLTSRTGLILGQNGEGLPFGELTEAAASPVNEA
VEVILKPREEFTVIGKPRTKSDARAMVTGKKQFATDLAIPDALPTVICRGPNLNSAPQGA
NNIDEVRNMPGVTDVEEMTTGVAVRAKTFGQAIDGVNALDVNWDGGTVEGESDQTVLDQL
RRAELPLAVPQVPGDTLEGDFTFYFRSNSSLETNCAIADVRGDTAEIWGPAKNPIAAQAE
IAKKLGIPQNSVTFHVTEGGGSFGRKLFSDAAEEAAEVSQLMGKPVKLMWTRSDDSRQGR
THPMATCRVRAQVSGEAVTAAAQKAPGGNYTVSQALYITTQTNPYNVGVATSLLNEIDMR
FNTSSMRNIYSPDTATARELMIDQVAAKMGKDPYEFRSAYTKLERYKKVLDRAAEEADWG
KSMADGTAQGIAMHVEYKGVAVAVVELDCRPETVNREIRSARTGPRVTKVTYVVDPGLII
NPRGYEAQMMGGINDGIAMTLTSGLHLEDGHFIEASWDNYFYTRQWNTPPEMNIVLIEDS
EAPEPGGAGEFGVAATCGAIACAYARAAGEVPTQFPILHNEPLPFEPYPTIPPVPPSPTD
GRELAR
>A0A7W8RSS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. Cpub6|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVF
PAAAVGDRKIVTIEALGATPTGQKVQQAWRELDVVQCGYCQSGQVMSAASLLARNPNPSD
ADIDAAMTGNICRCGTYHRVRAAIKHAAKGA
>A0A811H128|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter mucicolens|TrEMBL
MTAAAQLSRRAFLQGSLGVLTLAVTARGWVTTAVAAEPAAKAYGADSMPGGTVDDPLVFV
SIAADGAVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVVQAPGDEARYGNQNVDGS
RSMRHFLMPMRRVGAAARQMLEAAAAARWAVPVAEVKAEQHEVLHAPTGRRLSYGDLAAD
AAKQPVPAGDTLKLKDRSEFRYIGKDQVRLVDLEAIGKGQATYGMDMRLPGMVYAVVARP
PVVGGRLRRFDSAKALAVPGVLKVVEIPPMQGAPAFQPLGGVAVVARNTWAARQGRDALE
IEWDDGPNGSYDSAAYRQTLQAAARAPGKTMRNQGDAANAWAKAPEAERVAAEYYVPHLA
HASMEPPVATVQIKGNSAEVWTSVQNPAAAKNAVATRLKLEPANVKVNVLLLGGGFGRKS
KPDFVDEAAIVARAMPDGTPVKLVWTREDDIHHDYLHTVSVERLEAVMDAQGQVQSWLHR
SAAPTIASLFAQGAKGQQMFESAMSAINMPYRIPNVRVETAEVDAHARIGWFRSVANIPH
AFAAQCFIDELAHRAGKDPQAFALDLIGPARQIDPGTMADTWNYTESPERYPYDTGRLRG
VIEAACKGAGWGRTLPKGHGLGLAFCYSFMSYTATVVEVAVDDKGEVRVVAVDMAMDCGP
QINPERIRAQMEGGAIMGLGLALTSEITFEKGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHALPPGGVGEPPVPPVAPALCNAIFAATGKRIRSLPVRKVA
>A0A2S6SPH6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alphaproteobacteria bacterium MarineAlpha5_Bin5|TrEMBL
MPSSSIEFLLNNEVITINDLDINTTVLEYLRNYKNLKGTKEGCASGDCGACTAVLAEVKN
NKLKYKSINTCITLLYTLHSKQLLTVEHIESKYLHPVQQSMVDNDGSQCGFCTPGFVMSM
YAMHKKKINPTDLNINRYLSGNLCRCTGYRVIKDALKNLKKYKTLNSESSKIIKKLKKIK
LNDVTIKNKNSKFFIHQNLKNLKKDFIKSNNPSLLVGGTDLSLEITKKRKNLEEIFYLGQ
NKDLNFIKVKQNNMHIGSATPINDILSILKKYYPEFYEMFERYGSEQIRNVASLGGNIGS
ASPIGDSLPVLIALDTKLILEGNKSRKVSMSDYFISYRKTKLKKKEFIKEIIIPLKSKKN
ILKCYKISKRIDDDISSVFMAINTEIKNKKFKSIKIVCGGMSAIPKIANKTETFLKNKII
NFNNISKAKIIISKEFSPLSDVRSSNNYRKKIISNLLDRFWNEYNNNKVTLYDY
>A0A0E0ULD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium meliloti (strain BL225C)|TrEMBL
MNDMTPVTSEITASEIGKPFKLSRRGFLGASLGALVLGVTLPAGRARAQAAAAAITPGTR
ISAFLEILPDETVLFRSAFIEGGQGIFTAMAQIVGEELDVDPMQFVVEGAPPGPDYLLTG
GGRFTGGSMSVRMSYDAMRKLGASARHMLIQAAAVRLRVPVSELSTEPGRVVHGASGRTL
QYGEIADAAAGLPLPTNVVLRDRADFRWIGKPVPRLDVRDKSTGKARYAIDLKVDGMLHA
AVQHSPRLGGEPGALQNEADVRGMPGVHSIHSLPGTVAVVADSWWRARMAAEALQVTWTE
PTRGTAHVMPADFSTEAHMAMLKATPGEGVAYETVGNAATALGDAARVVEATYDAPYLVH
GQLEPPSALARWNDDGSLDLWVPNQAPEMFQAEAAKVAGIAPEKVTIHSPMLGGFFGRHF
LYQTANPFPQAILLAKAVARPVKLIWSREEEFLRDTLRPMGAVRFRAGLDAEGLPVALEA
VAVGEGPTGRWFGRQPDKVDSSSVEGIAGKVYSIPNRHVGQVHVDDPAIIGFWRSVGHSM
NDFFYETFFDEMADAGQQDPYELRRRLLADSPRHRTLLEAVAELSGGWRRGPFIADDGTR
RARGVAMASPFGSEVATIAEVSLRSGEVVVHDVWVAIDPGSIVNPAIIEAQVNSAVALGL
SSALLEEVVYVDGMPQARNYDGYPILTPDRMPRVHMRIVESGAPMGGIGEPGLPGVPPAI
ANAVSVLAGRRVRSLPLSKHDFKEVDG
>G2LLQ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chloracidobacterium thermophilum (strain B)|TrEMBL
MTLIVNLSRREFLAGATLTGVALTLGCHVESNGVRAADSTAPVLAPNAFVTIRPDGRILV
TVNKTEMGQGVRTSLPMLVAEELDADWSQVTVETASFDPSRYGFQGTGGSGSLRGAWEPL
RRTGATARAMLVEAAARRWNVPADACRTEAGFVLHPSDATKKLSYGELVADAANLPVPDP
KAVKLKDPKDFKLIGRRVPRYDNPDIVTGKAVYGMDVRLPGMRFATMVHPPVFGGKVRQV
EDTEAKRVPGVEQVFVTDRGVAVVATNTWAAFEGAKKLRITWDDGPHAKLSSADIRAMFI
EKSTSPGDVARQDGDFDKAFASAAKQLEAVYEVPYLHHATLEPQNCTARVSAEGCEIWAP
TQFPNFVMDEARRITGLDAGRIKIHVTLLGGGFGRRIEADYAADAVEVARRLNGVPVQVT
WTREEDMQHGWYRPASLHVVKAGLAENGQPVAVLHRLVAPSIRGQRQPDGGKGVDPGAMA
GITTTAYELPNFRAEYVRANTAVPIGFWRAVFDSQNAFVQESWMDELAHAAKADPVEFRL
VRLGKAPRLKRVLEVAAKAAGWGQPLPRGRARGVASHFSFGAFCAQVAEVSVEDDLPRVH
RIVCAMDVGTVVNPSQVEAQIEGSIAFALSAALYGAITVEQGRVVQSNFNDYPLLRMAEM
PRVEVHLIPSSESPSGAGEPALPPVAPAVCNALFALTGKRIRKLPIELDT
>A0A7W6DKQ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sagittula marina|TrEMBL
MTKMNRRGFLTSSAGLVIGLSLPIAARAQSGAALAFESDGTEGTFAPNAFVRVAPDDTVT
VMIKHIEFGQGPYTGLSTLVAEELDADWSQMRAEAAPADAVYKNLAFGMQGTGGSTAMAN
SYMQMRKAGAAARAMLVAAAAEEWGVDGSEITVSKGVISHGDKTSAFGALAEKAAQQTVP
EDPTVKTADQFVLIGQDLPKLDTVAKSNGTATFSMDLYRDGMKTVVVAHAPKFGGAVASF
DDSAALKVPGVEAVHQIPQGIAVYATSTFAAIKGRNALDIQWDDSNAETRSTDAIFEAFS
EAAAQGGQDAEMIGNGAADIDGAAQVIEAEFRFPYLAHAPMEPLDGLIEYSEGKAEVWMG
SQFPGLDHPAVANVLSLEPANVRVNVMLAGGSFGRRAQDTAHFANELAEVAKAAGPGTYK
LVWTREDDLHGGYYRPLTVHKMRAGLAEDGTLTGWEDVVVNQSIMAGGPMAQMMQDGMDP
TSYEGSTKMPYDLAHARTGWAQMESPVSVLWWRSVGHSHTGYATEVFLDMVLEAQGKDPV
QGRLDLLKSDMTRDRGVLEKVAEMAGWDGEKVKGDKGYGVALHESFSTYVAQIAEVSDVD
GMPKVHRVWCAVDCGVAVNPNVIRAQMEGGVGFGLGTVLFDEITLADGGEVQQSNFDTYR
MLRIHEMPEVTVEIIQSDADPTGVGEPGLPPIGPAVANAWRALTGETGTTLPFAKKTGA
>A0A5M9J152|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas extremaustralis|TrEMBL
MSVLTINGREYTVDVDPSTPILWTLRDTLGLTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGRKITTIEAATNGSDPVGAAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTAAEIDSAMAGNICRCGTYARIRAAVADAAKVLA
>A0A840THM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhabdobacter roseus|TrEMBL
MSLLPNTSRRDFMKLAATAGGGLLLGFHGARAAAAEPMILDANAASAALDFNSFLAIAPN
GTITIFSPNPEVGQGIKTAFPLIVAEELNVDWKQVNVVQAPLDTKKYERQVAGGSGSIPH
SWKRLREAGATARVMLIGAAAQRWKVPAEACTAQNGMVLHKASGKKLSYGELAQDAAKLP
VPQDVKLKEYKDFTLIGKTYKNVDNQAIITGKPLFGLDFYREGMLFAMVQRPKAFGMKVK
SVDATQAKAMPGIIDVVTFRNNVAVVGKSTWQVKKAREVLKVEYEAEGALESTADHNRLF
DELLNGSEATVRRQDGDVEAAFKSAAKVVKSEYQCPFLPHNPLEPMNFFAHVREDGAELI
GPTQTPERARGEAAKYLGLPPEKITVEMTRMGGGFGRRLAADYVMDAVEVSKLAKAPVKV
IWTREDDMTAGNYRPAVKYRFEAALDAKGNMIGYKLRGVGINAGNPTREQNFPSGAVPNL
LIDSVEHKSPITTGPWRAPITNFLAYAEQSFLDEVAEAAGKDPVQFRQDLLEQAKKTPTG
DVKYDLDRMIAVTKLAAEKSGWGKKKGPDGKPLAQGFSLYYSHLSYVAQVGEVVMEKGKP
VVKKIHAAVDCGVVINQSGARQQVMGGIVDGMGHAMYGNMTFKDGAPDQSNFNSFRLIRV
NEIPEVEVHFVNNGMDPTGLGEPALPPTGAAVSNAIFKATGKRLYKQPFVEEEPFKGIS
>A0A6S7BKN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ultramafica|TrEMBL
MTTFNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVF
PAAAVGDRKVITIEAIGGTPAGQKVQQAWRQLDVVQCGYCQSGQVMAAASLLASNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGA
>A0A840HGC5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ERR14|TrEMBL
MNAHNSVSRRALLTGGLATGFLLAFHLPLRAAVNEPVQPRDATEGKFAPNAFIRIDETGR
TVLMMPQVEMGQGTYTSISAVLAEELDADWSRVEVQHAPPNDKLYGNPTFGLQVTGNSNS
IRAWWLPLRKAGATARAMLVQAAAAQWGVEPASCTASKGEVAHEASGRKLAYGALALAAQ
GQTPPKDVALKDPKDFVIIGQPLKRLDTPDKVNGKAVYGIDAILPGMKFATVAACPVFGG
KVGKVDDSAAVKLPGVRKVVVLDDMVAVIGDHMWAAKKGLEALKIEWNEGPNAAITTKDV
WDDLRKASQKDGVVAKSDGDIAKALASGDKFEAAYELPFLAHASMEPINATVHVKPDSCE
VWTGTQIMTRVQSEAAKAAGLPVDKVIVNNHLLGGGFGRKLEPDMVIAAVKIAKQVDYPV
KVVWTREEDIQHDVYRPVYRDQITASLVDGKVAGWKYKVAGSAVLARWLPPAFQKGIDID
AIDAAVDAPYDFANFHVEYVRAEPLSVPTGFWRGVGPNNNVFAVECAMDELARKAGKDPI
EFRKSMLTKNPRMLAVLNQVAEKSDWGQPLPARVGRGVCVQPSFASFIATVVEAEIDDIG
EIVLRRITSVVDTGIAVNPDTVKAQIEGGLIFGLTAALYGEITIDKGRVQQSNFHDYRMM
RINETPKIDVIVVKSGEAPGGIGEAGVNAGPPALRNAILAATGVALRRLPIDRKLLAAGK
KA
>A0A6J5GI73|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MSQGLLDAQNGAGASQSSVAGMSRRTFLKFGVTVGAAAGGGLLLGFSLPAASQDQKAGKS
VVGGDAVETPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELDVPLDA
VTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARIMLIDAAAQQWQVDPA
SCHAQGGQVIHAASNRSIGYGQLVEAAAKLPAPQNVPLKEPKDFKLIGTPVKRLDSPEKV
DGTALFGLDVRMPDMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQVVKIDNAVAVIGDH
TWAARRGVQALDIKWNEGAGANLSMKQIVDDLADASQRNGAVARKEGDVGQAFSNAKSRV
DAVYQQPFLAHATMEPINCTVHVRADGCDVWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LIGGGFGRRLEFDMVTQAVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLDANG
KPLAWQHRIVGSSIMARFAPPAFKNGLDPDAVEVASDLPYDLPNQLVDYVRQEPHAVPTA
FWRGVGPTRGTFVVESFIDELAAQAKIDPVKYRQDLLGKTPRALNVLNVATQAAGWGSAL
PKGQGRGVSVMHAFGSFFAIVVDVAVDQGEVAVKRVVCAVDCGMVVNPNTIEAQVQGGII
FGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIDVHIVKSSEAPGGIGEPGTAALA
PALTNAIFAATGKRLRQLPVGSQLQTA
>A0A6J5GTE8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MSTSFVLNGKNITLDADPTTPLLWAIRENAGLHGTKFGCGMAQCGACTVHLEGEATRSCV
LPLAAVAGKRITTIEGIESRSAKAIQAAWVKLQVPQCGYCQSGQIMSATALLEHNATPTD
ADIDAAMNGNLCRCATYVRIRAAIHEAAATLKA
>G8TM86|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Niastella koreensis (strain DSM 17620 / KACC 11465 / NBRC 106392 / GR20-10)|TrEMBL
MASYTITINNNKHTVDVLPDTPLLWVLRDELNLVGTKFGCGIAQCGACTVLMNDNAIRSC
SYPVSAVGTNKITTIEGLSENGDHPVQKAWDQMDVPQCGYCQAGQVMAAVALLKRKPNPT
DEDINAAMSNICRCATYVRIRKAIHLAAGNAASK
>A0A7D5SCG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Kapabacteria bacterium|TrEMBL
MEINVNKKNYTVDVDPDMPLLWVLRDILNLTGTKYGCGIGVCKSCTVLIEGVPEQSCIVP
VSYAEGKSITTIEGISENGDHPLQKAWIELSVSQCGYCQPGQIVRAYYLLSKNPKPTVED
INKEMSEHICRCGTYDKIRKAILLASKE
>A0A0D6SAI0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. FeS53a|TrEMBL
MSNRDFSRRAFLQGSVIAGIGVTLAPLGSPAFAALFEDRVTASPQSWFTPNGQARARIDG
VSKACGAKVFARDIRAQDMPGWPRQQGHAMLIKATRADHLYAGLDLSMLDAGLQPDRVVT
AADLARDGIAFPEGHSPDPLLPEGQVPMFIGHPVALLIWNDFERFRRAKNLLRYNDKVVR
YGAQAALFERDPYGSFRFVRVGGDTPYEADRFSSLKDSMLFPIIRQRKPTWSQQADINGD
LTQQGLFHAQQMEQTLGAPPEGWLVFDERYTTQSIEPAALEADNGNGWYDAATGTLHFVV
ATQCPFEAAEQTAHMLAPSRFKVRKLNMHPGYTVGYGTKDNNIFVFYAALAAIYGEGVPV
RLANDRYEQFQSGIKRHPFDMHYQLAVKKDDLSFQIFRAHMDVDGGGRINYSPSVAAVGA
TAAQSIYYMPQSDLAATAYHSRGVEAGSVRGYGTLQTMAATEMMVDEVAERLGVDAIELR
RRNVFKSGMKNTQGAIPAGALRLDEILDKAAQHELWKQRDARKREEEAKDPDNLYGIGFA
ICQKDFGTGAEAPMASLEFNAEGRVFLRQIAIDMGTGTATSQALLVADYLGHPADEIRTG
VTEWPELGLTTSGNPYLISQAEQDAALKNPRWVGKLASPSSATNSSYYSGHATREAARVL
FNHGLWPAALAIWGRGEYGGLANPYVVRREDAHWVEGKLTANGLPPIPFELLAHKAHELG
LVTGVSVHGFNRWAWAEAEFEINGNRDTLPLDALAVKYGDGAPAATRARMNRDGYHLLDR
TRVEYPPTQLNNAMVTYYSPVATLVEVKVNKGSGEVRVLSHHSWLECGRVIVPELVHGQL
EGGIAMGIGHALLEEMPRYEGGPGEGTWNFNRYVLPRAKDCAVWNQSAEILPPLSPSDPA
KGIAEVVMIPVVGAIVNAVAHATGKRLRDLPLNPARIKEALHG
>A0A1E1VB78|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. BIWAKO-01|TrEMBL
MAHAENLGDHVVSRRSFLHASAAVGGGLMIGWPLQVGAQPAELAQAKPFAPGAFIRIDRM
GKVTVISPMIEMGQGTYTSLPMLVAEELDVDMSHVVVEPAPANAKLYGNPLISGVQMTGG
STSIRAFYLPLRHAGAAARKMLIAAAAARLNADAGSLTTQPGYVVHAASSRRIGYGELVD
AAAKLTVPSDVTLKDPGSFRIIGTPAKRLDASAKVNGTAIYGIDVRLPGMKIATVAASPV
FGGTVASFDEAAALKVPGVHQVAKLDNAIAVIADHYWAAKQGLEACAVRFEDGPHAATSM
ADIVAALATASERPGAVATNEGDAIAALAKAATRVAAIYEAPFLAHATMEPINCTAEVTS
DGCDIWVGSQVPDIAQLVVSKHLGLKPEQVRVHNHLLGGGFGRRLEVDFIAQAALIAKQS
KGPVKVVWSREEDIQHDMYRPYYYDRMSAGLDAQGMPVAWNHRIAGSSIMARYFPSAVKD
GVDPDAVEGAAEIPYAIANMHVDYVRVEPPGIPTAFWRGVGPTHNVYVVESFIDELAAAA
KKDPVEYRRALLAGNPRALHVLERAAQKAGWAKPLGPRQGRGIALSQSFGSYLAEVAEVT
VSKSGDVHVDRVVAVVDCGVAVNPNTIAAQIESGVVFGITAALYGEITLRNGRVEQSNFD
SYQMLRIDAAPTIEIEIVGSSEAPGGLGEPGTSALAPAVLNAVHAATGIRLRKLPIKPEM
LMAG
>A0A840NQ17|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora gloriosae|TrEMBL
MEQRRSLHPETPDALAGTEPGSAGLGRRRFLGLLLAAPTVAAAAQLGQLADPAAAHAALP
EPSDIFDLNDLLTEAALPTSNLISVQVNPDGTASFALPRVESGQGITTMVAMIIAEELDL
PVEKVDVTLADARPELMFNQFTGGSNTAISIYTPVRVAAAIARGRLLQAASAQLGEPVSL
LTSKLGVITSVAGTQLPYGELAEKAASDVTKQVEAVLKPESEFRVLGKPQNRLDARDAVT
GRKQFSMDLDVPDALPTMVCRPPTIKGTPESVANLDAVRDMPGITDVAVISTGVAVRGRT
FGQCIDAVNALEVAWGPGSVDGESDETVLEKIKAAEIPLVVPDVGETVEGEFTFHFRNNA
ALEPNTAVADVRDDGVEIWSCLQSPILCKQEVAAKLGIPQELVTVHVQQGGGAFGRRMFN
DVVLEAVEISKAMGKRVKLMWHRTDECRQGRTHPMCTSRIRAGYTGDKVLTFEQRHTSVA
TDYTMGFAEAITSLAARLPPLGLGNFAGFSLPVFELTVGVPYKFGVTTQLLNEIMQYDTF
PTGSNRNLFNPDVRTAQELIVDQLAAKLGKDRYEFRRSFLDDERLIAVLDKVAEVGQWGR
STEPGIAQGLAVHKEYKGASATLVEIDCRPETVNREIRNAVTGPRVTKVVLAVDTGLALN
PRGLEAQMQGGISDGIAQALTSSLHLKDGTFLEGSWDDYFYTRQWNAPPEVEIIIMPPTT
GKPGGAGEFAVPSAMAATACAYGAATGTMPTSFPINHGELSFTPKPTVPPLPQSPTNGLD
FAY
>A0A7W5PUH6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK312|TrEMBL
MNLQINNQSYQVDSEGDTPLLWIIRDELGMTGTKYGCGLAECGACSVLVDGEVVRSCVTP
LDSVAGRQITTIEAIEADPVGKRVVAAWVKHQVPQCGYCQSGQVVAATALLKQIPNPSDD
EIAAAMINLCRCGTYNAIKTAVKDLSSKEGETL
>A0A3G7U935|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MTSQPITVTLEVNDQTSEVSAMADTPLLLVLRNDLQLNGPKYGCGLGECGACTVIIDGVA
ARSCVFPLSGAAGRRIVTLEGLGTRQAPHPVQQAFIDEQAAQCGYCLNGMIMTAKALLDR
NPKPSETQVRNELSGNLCRCGTHIEILRAVLRAARLMNVDG
>A0A0A8K1D9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methyloceanibacter caenitepidi|TrEMBL
MSLRLTDKPQTPSAGGLSRRGFLRASVAAGGGLLLTFGLPIRAARARDASAANFAPDGFI
RIGHDGRVAFIIPQVEMGQGTFTSCPMLIAEELEVDLTQVYTEQAPPDGALYTNGLVGFQ
VTGGSTSMRAFYEPLRNAGATAREMLIAAAAATWNVDPSSCRAEKGSVIHGATGRSLGYG
ALAEKAATMPVPEKVTLKDPSAFKLIGTAAKRLDTPGKVNGTTVYGIDAKAPDMKFATLA
ICPVFGGKVKSVDGAKALENNGVLQVVQTEDAVAVVATNTGAAKKGLAAVEIVWDDGPNA
TLSTADIVADMEKASEADGVLVRHEGDVPNALEGAAQTLDEIYEVPFLAHTAMEPLNCTV
HVRKDACEIWVGTQVIGRAQAIAAELTGLPLEKVVVHNHMLGGGFGRRLEVDSIAIAVEI
AKQVDGPVKVIWSREEDVQHDMYRPYFYDRLHAGLDADGMPIAWSHRICGSSVIARWASP
AFKDGYDFDTVDGALEMPYEIPNVRLQYVRHEPPGIPTAFWRSVGPSHNIFVVESFVDEC
AAAAKKDPLEYRRALLTKEPRALAVLDLAVEKSGWGQPLPERSGRGIAVQNVFGCYMAQV
AEVEVSDSGDVTVKRVTCAVDCGLPINPNTIEAQVQSAIVYGLSAALFDEITLENGRVEQ
SNFHDYRAPHINDMPAIDFHIIKNTEAPGGIGEPGTSAVVPAVFNAVYAATGVRLRKPPL
SAESLKA
>A0A653M180|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Maribacter litoralis|TrEMBL
MANFSLKVNGKTQEIDVDPSTPMLWVLRDHLKLVGTKFGCGIAQCGACTVHLGDNAVRSC
QLPVSAVGEQSITTIEGLSENGDHPVQKAWLEEDVYQCGYCQAGQIMNASAFLKRNPNPT
DTEIEDAMNGNICRCGTYTRIKKAIKNAASISNA
>A0A846QYD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saonia flava|TrEMBL
MANFNLKVNGKNEQVDVDPATPMLWVLRDHLKLVGTKYGCGIAQCGACTIHLGDNAVRSC
QLPVSAVNDQDITTIEGLSENGDHPVQKAWMEVDVYQCGYCQAGQIMNASAFLKNNPNPT
DEEIEGAMNGNICRCGTYTRIKKAIKEAASSENA
>Q8ECT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella oneidensis (strain MR-1)|TrEMBL
MSTFTAVENISRRDVLKLFGAVGGGLALGASGLSWSPMALAQDQQARLNLFIAIGEDDKV
YLTCHRSEMGQGIRTGILQILAEELEADWDKIVPIQGLADKRYASQNTDGSRSIRENYDR
MREMGAMARTMLEQAAAARWKVPVTEVQAKDHKVMHAKSGRSARFGELALDAAALPLPAA
DSLRLKAVKDFKQIGASRQIVDMQAMLTGKAVYGYDIQVDNMLYASIVRPPVLGSDVASL
DDTAARKVQGVVDVYRLPTPKGAPAFQALGGVAVVATNTWSALQGRKALKVTWTQSANSS
HDSKTYLQELVDKVQAPGKVVRQVGDEVKAWPEANTLKAIYTVPYLIHSSIEPPVATANV
TEKGCEIWASTQTPQSTQQNVAAALGIAEDAVKVNVTLLGGGFGRKSKPDFSVEAALLSK
QLKRPVKVSWSREDEIQNGYYHAISAQCYQALFDTNNQPTALLARTGFPSISSTFAEGVE
YPSDGELDLGFVDVPFALPHLRYEAVKATAHSRIGWMRSVCNIQHGFGVGSFVDEMAHKA
QLSCPDMWRSLLGQPRRETFDNQGFKYGNYGEELTRHPVDIGRYLKVIEAVEQAQAKAPK
AGKNQGWGFAVHRSFVSVVAVAMRVEVSEDKQLKVLNAIAAIDAGTVVNPDRVKAQTEGA
IVFGLSLALMGEISYQEGKVVQSNFHDYPLLRLPQVPEIEIIIIDSDAPPAGVGEPGVPP
VAPSLTNAIFAATGVRIRDLPVNKQLKV
>A0A0N0NH14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinobacteria bacterium OV450|TrEMBL
MPSHTFTVNGRSVTVDAPDDLPLLWVLRDLLGVRGPKYGCGVDVCKACTSHLDGADIRPC
VVPVSACRGKTVTTIEGLANGDELHPVQEAWLEQDVSQCGFCQPGQIMAAVALLERTRTP
TDEDIDAIANICRCGTYFRIREAIRSAAARM
>M4V0M2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum FQY_4|TrEMBL
MVTLTINGRLVEVDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAAVGAQITTSEHIADDKIGKAVLAAWIKHDVAQCGYCQSGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAARSLA
>A0A3B0RRS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MAEMNEKGLARRKFLKRTGWAAVGVTFVGVAFVGASDGPLLPVMPFSDPPAADEGKFWLQ
LLPSGKVRFFCPRAEMGQGITIGLSQVVGQELNLNPEDIENVYPSTKEIPPVALTVGSES
MQNFFKPVAYGAAYLREALRSIAAKQAGVEISKLVDGDAAFILPGGKTISYKELANGKPV
LLDEDKAFPDDLKIYNLDPKRAAGRKQQNWGRAAMEDIVTGKMKYSRDVIIEGMLYGRVI
KPDAIGGQLADADIARAQKLPGVKKVFVDKDRNCVGIVCDNPFVLDEVTQAVKVNWEVEK
PFSQKAMDATLDVKKYLDADDFEHVLVEHGEFGGDSQDGSGALSKRYQTSFVAHAAIEPR
GAVAWVKDDSAEIWGASQSVHFVRDRIAQLTGISDDKVVVHAHRLGGGFGGRVLCQAAEE
AAFLSQQVNAPVRVQWTREEEFKYNHVQPPFDHMIDATVSENGLITHWRDSFTTAPIIFT
SAILPGHIQFLADFTQEDGSPRGAQPTYKIPNLLVRYSDIRIPLVTSAWRGLGAAPNTFA
IESMIDELAVLSGLDPFELRLMNLGNNHARLKKVIETVREMSLLKQKLPANHGRGIACAI
YKETPVAVVVEVHADPAKKTLKVTQAWIAQDCGRVINADQVRAQAEGNLVWGLSYALKEK
GSLENGGIAMQNFHQYPLARMSDIPKTHIELVENFKNPPIGAGESVIAPTPAAIANAIFA
ATGKRIRRLPILPEDIFS
>A0A7Z0CIW3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides aromaticivorans|TrEMBL
MGKSPARASARPLSRRSFVGYVMGGTSLVVAADLVAGAAPAHAVPIPSLPQVPELYDLND
FLTHCALPTSNLIAIHVDEEGHAHFALPRMEVGQGITTSIGMLIADELDLPLDRVHVTLA
PARPELLFNQLTGGSNTMISMYTPVRVAAAVARKALLDAAAVQLGALVTTLTVKGGIISD
LLGNTLTYGEAAATAASPTTKRVRVRLKAAADQSLIGTPQRRVDALDAVTGRKQYAMDID
VPDALPTMVCRAPDLNGTARSVRNQADVASMPGVTHVAIIPTGVAVRARTFGQCIDAVRA
LDVEWSPGTVVGKSSADILGELRKAQLPLVVPKLGASTVEAEFVFHFRSGSALEPNCAVA
DVRDGTATIWGGLKSPIDTQSKVAKALGLPQGKVTVHVVQGGGSFGRKLFSDAAIEAAHA
SKAFGAPVKLMWHRADEPRQGRVHPMTTSRIRASILAGSVISFEQRHTAVTTDFTHGLGE
RLTAEVAALPTGLANLTFSESIFTLTQELPYNFGVVTQLLNETDHDVRRFNTSSVRNVYS
PEVRCANELMVDQLAKRFKQDPVAFRRAHLRSGIVKRVLERAAELGEWGRTMPPGTAQGI
AIHKEYKGATAVLVEIDCRPETVDRKVRDAVTGPRVTKALVVVDCGLVVNPLGVQAQMMG
GFMDGMAQALTYSNHLVDGHFLEASWDNSAYTRQWNVPFEFRCEVIDSDRKEPGGAGEAG
VAASMAAVACAYARATGTLPKEFPINFHAPLHFEPKPFVPSVPESPVNGLDHTF
>A0A3B0TRZ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MSTSISSKFSRRSFIRTSSLASGGMLIGFNLFNACKPKAEMPVDISQLNFNDFNAFIKIA
DNGMVTIFSPNPEIGQGVKTSMPMLIAEELDVLWKNVHVEQGILDTTNYTRQVAGGSQSI
RSAWEPLRQTGATARQMLVNAAADRWGVDASECVTKQGVITNSKGETLGYGDVVREAATL
EIPENVVLKEPKDFTIIGIDAPNVDIDKIITGKPLFGLDYKVEGMVYASVLRPPAFGQVL
ESFDASEAKTMSGVIDVITIGEKAKALLNNEKQNWTVKLTITDKVVVIAKTTWQAIKAKK
AIKAKWTDGTPLESTVFQDKKLMALLDGKAFDTLRKDGNVKRAFKNADKVVERTYESPFL
PHNCMEPMNFFANVTADKIHLAGPIQTPEFAALAVAEMLEKNITEIHLEMTRMGGGFGRR
LYSDFVLEAAEISQTIQKPVKMVSTREDDMTTGVYRPAIKYRISASIKNGELTGYHLKEA
AVNGNMYGLIPNFFPAGTIDNYQVDVATYKSNVTTGAWRAPYTNFLAFAEQSFLDELAEE
LGKDPVQMRLDLLQNVKGTTDDRIQYSAERMEGVIDLVVEKSGYRNPKEGVYQGFCAYYC
HNTHVAEVADVVMENNRPVIKKVTVAVDCGIVVNPLGALNQIEGGVIDGVGHAMYSDFKF
KDGKPNSDNYDTYRLIRMKEAPEVETHFVENTYSPTGLGEPTLPPAGAAVSIALRKAMGN
RIYKQPFISSMLNKEIVG
>A0A1S6HMY0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella psychrophila|TrEMBL
MSDNNLTLKINGKLFQMDADPKMPVLWAVRDMLGLTGTKYGCGAGLCGACTIHVDGKPAR
ACLTSLSQVQGKELTTIEGLEADKLKRAWTEHNVPQCGYCQSGQLMSAAALLTTNSKPSD
RDIDEAMAGNICRCGTYTRIKSAIKSASDQNSFTQHSDESSDNSRVEQEVTA
>A0A7W7MKH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes lobatus|TrEMBL
MTTSRRRFLGYVLAAPVLVAAASPASLGEAAAASLGEAQAAELLDLNDIMTAAALPTSGL
IAVEINADGTVSFALPRAEVGQGITTSTAMLIAEELAVPLHRVKITLADARPELLFNQMT
GGSNTTIATYTPIRVAAAVARQRLLAAAADEFGSSDLRLADGVISTRDGRRIGIGELATK
AASPRTLAVPVELTAKDDFTVIGRPHGRIDARDAVTGRKKFAMDVTVPGAKPAMVCRPPT
INGKPGTVANLDEVRAMPGVTDVVTISTGVAVRADTFGQCIDAVRALRVTWKPGTVEGQS
DTTVARELASAELPLGPRPITPYVEGRFTFHFRSNSALEPNCAIADVRGGRAEIWSALKS
PIVAKQSIAARLGLPVSAVTVHVTEGGGSFGRKLFFDAALEAAELSQKLGKAVKLMWHRA
DDSRQGRTHPMATSRVRIAYAGNLVLGFEQRHTSVTTDLGHGLGELFTAMAAKLPIGDKA
FAQTFFQFSHTSPYDFGLHSRLLSETGKGFNTGSMRNVYSPDTTCARELVVDQVAARMGR
DPYRFRHDLLRGDRSRAVLRAVAETGGWGRTLPAGVAQGIAFHSEYKGVSACLVEIDCRP
ETVNRPIRDGVAGPRVTRAVFAVDVGLAVNPLGLEAQMMGCVMDGIALALTSSLHLRDGY
FLEASWDNYFYTRQWNTPPDLRIIIMPSDSDQPGGAGELGVSAAMAAVACAYGRATGTMP
TTFPINHGTLSFVPKPTVPPIPASPVDGLDHVR
>A0A839UEG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MTTLNINGRDHEVDADPETPILWVLRDTLGMTGTKFGCGAALCGACTVHLDGEATRSCST
PISAAEGLKITTIEKVTDGTDRVGAAVHAAWIKHDVAQCGYCQSGQIMSATAFLASLPKG
TQPTPAEIDTAMEGNICRCGTYARIRAAIADAAGTLV
>A0A0P7ZSA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium HLUCCA12|TrEMBL
MARRKSGKLGRITRRSLLVGSVAVAGGVAFGVWKIRQPVANPLNPEQGATLNPFVIIDRD
GVTLVTGRAEMGQGTQTTLAAMLAEELDLDWDSVRVIHGPADAAYYNGALLEAGLPVAEY
AMRDWQHSVAGVVGDMGKLFGLQITGGSSAMRDGYERLRHAGASAREALKAAAAERLGTT
PDTLRTEGGAVVTADGARLPYAELAEAAAQRPAPEVAPRDPSQWRLLGKALPRHDMLAKV
TGTATFGSDIRLPGMKFASPRMSPRLGGTMRSHDPEPALAVPGVERVIDLGTGIAVVASN
SWAAMRGAEAVEIEWGPAPYPPTTDAIFERIADAFDGRRNSRLRDDGDVERTLEQAESVV
EAEYRLPFLAHATMEPMNATALFTDDALELWTPNQTPLIQARLAAEAVGLDPEQVTVHTP
FLGGGFGRRLEADYSVLAARIAQAMPGTPVQVVWSREEDMTHDFYRPGILARMRGVVANG
RAEAFEARIAGPSVTHQAGRRMIGLPLGGPDKGHVEGAFDQPYRIANYRVDGHHADLDIP
LGFWRSVGSSHNGFIHECFIDELAHAAGRDPMDFRLDMIRPESTVAARVLEAVRDMSDWD
TAKAPDTGRGVAFTWSFGTPVAEVVEVRDENGRIRITRAWIACDMGRALDPGIVRAQMES
GLIYGLSAAVSGKITFEDGMVTERNFPDYDVLRMHTAPIIETRILENQSRLGGGGEPGTP
PSMPALANAVFDLTGQRARSLPLDQQFDFVT
>A0A7W6WVI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MIKVKINGQEQSWDGDPDLPLLWFLRDEAGLTGTKFGCGQALCGACTVIVDKEAVRACIT
SVNDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLMDNPKPSHD
QIRESMSGNICRCGCYQRIENAVHLASTGV
>A0A7W6ST44|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. cir1|TrEMBL
MANLTINGKTLTLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHIDGVATRSCGV
SVAEAEGKKITTIEGLASGGTLHKVQEAWIAKDVPQCGYCQSGMIMAVAALLNEKPKPTD
ADIDEAITNICRCGTFQQVREAIHTIASA
>B8KPR1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|gamma proteobacterium NOR5-3|TrEMBL
MIEFKLNGKQVSTDSPGDTPLLWVIRDEQQLKGTKFGCGIAQCGACTVQRDGVPVRSCVL
PVSEVAGTDITTIEGLASAEGTALKEAWVDAQVPQCGYCQSGQIVTAEAFLKSNPNPSEE
EITQAMTGNLCRCMSYTRIRSAIKSAAQGEVNS
>A0A508SSX5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MGAMQNLSRRAFIIGSAAVAGGVAFGPCSNAEQAAPVANGNPLAAGLGSNSATFNPWVEI
SPEKITLIAQHADIGQGVGSVQPILIAEEMDLDPGQFEVRFAGPSPAYFNTGFADEFAPF
LAADQSPAAEAARAAVLQNLRKSGLQMTGGSSTIPDTYEKLRIAGAVARETLKVAAADRA
GVALADVRTQSGHVILPNGTKIPYVALAADAAKIAPVLDVKPRDPSTWRLVGKPMTRLDI
KSKVMGELKFGIDLKMDGMMYASVKLNPNKGQPLKSYDARKAQAMPGVKKILEIKNGVAV
VATNSWYAMKAVAAIDCEWAPSTYPAEQADHWKVLESSFKPEFLGKEWRKIGDVETGLKA
GTLVEAEYRAPYLAHAPLEPLNGIGIVTDTGMEIWVGHQSPQFVQSVAATAIGIKPEQVT
FHNQWTGGSFGHRLEYENVRVLAEIANQMRGTPIKLVFSREEDFIQDIPRQISIARHRGA
VDKGKIVAADLQLASTAPLKGLLERSGIPSKDPDAQLASGLWNVYYDIPNFRATTFEAQG
LSPCTTWRSVGASTAGFFTESFIDELLHAAGVDPLKGRIEMCAVPHYRKLLETLAEMSDW
KGPLGNGKGRGVAFVEAFGTPTAEVVEVTATDRGIRIDKVWIAVDVGKVVDPVNFENQVQ
GGVVWGLGHAINCELTYAKGGVQQTNYHHHEAMRIYQCPVIEVRGLENDPKVRGVGEPPV
PPAAPALANAIFAATGKRIREMPFNKFIDFV
>A0A508TFB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MKYALKINGMQKTVDVDGDTPLLWVLRDVLNMTGTKFGCGMALCGTCTVHVDGAAARSCA
TTIDSIGDAAVMTIEAIGDTPVGRKVQQAWFDLDVVQCGYCQSGQIMSAAALLTSTPHST
VSEINTAMSSNVSRCGTYNRIHDAIQRAALDGEANVKVERVVCAVDCGLPINPLTIDAQV
QGGTIFGLTAALHGAITFKDGRVEQSNFDSYLPLRIDETPRIETHIVPSRAGPGGLGEAA
TAVVAPALTNAIFAATGRRIRRLPVQSA
>A0A2N9AH84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens|TrEMBL
MNDLTPHHRLAARPASEPVRNLSRRGFLGIASGALLLGIDLSKEAVAQTRAEGPTAVAAK
PGTRVAAFLEIRPDGDVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFAVECAPPGPDY
AVVNGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAARLAVPQDSLTTDDGRVIHAAS
GRTLGYGEVAQAALALLPRDDVALKNPKDFRWIGRPVARLDMRDKATGRATYAIDIRLDA
MLHAAVQHAPHLGTEPRAVVNEAEVRAMPGVHSVHRLPGAVAVLADSWWRARKSAEALQV
TWSEPAPEGIATVSATFSSAAMLAALKSTTEPGLPAEQEGDPGAAFANAAKVIEAEYDAP
YLAHAQLEPPSAVARFTADGSLDLWVPNQMPELFQQIAAKTAGLEPEQVRIHSPMLGGFF
GRHFAYGPANPFPQAILLAKATGRPVRVLWSREEEFGMDAVRPLSFARFKAALGPDGMPV
ALQTTAVGEGPISRWFGALFTSPVDSSVVEGLDKKPYAIPNRRLDYVRVAHPVTIAFWRS
VGHSMNDYFYESFLDEIAAAGGRDPFDLRMALLTNSARHATLLRKVAELAGGWRRGPFVA
EDGTRRARGVSMASPFGSETATIAEVSLEDGEARVHDLWIAIDPGSVVNPAIVKRQVESA
AALGLSSTLLEQVVYENGQRQARNFDTYPILDRTRMPRVHVAIVESGAPMGGIGEPGLPG
VPPAVVNAVAVLTGQRVRSLPLAKTRLSGV
>A0A508WWQ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium medicae|TrEMBL
MTAFTINGRAVDVTAEPDTPLLWVIREHLKLTGTKFGCGIAQCGACTVHVDGEPTRSCQT
FLEDVAGREVTTIEGLSPASNHPLQKAWIAEQVPQCGYCQSGQIMQAAALLAATPNPTRE
QIVEHMDGNICRCGTYVRIISAIQRAAREG
>A0A5E7YFW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hoeflea sp. EC-HK425|TrEMBL
MKLTVDGKIHEVDVEPDMPLLWVLRDELGITGVKYGCGIAQCGACTVHVDGYAIRSCQQP
VGDLEGEVTTINGLGTPDALHAVQAAWIEHQVAQCGYCQSGQIMSAAALLAENPNPSDED
IDDAMSGNLCRCGTYPRIREAVKTAARTVRSA
>A0A2S9YSX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Enhygromyxa salina|TrEMBL
MSETTKTRTGVGRRNFLVTSASLILGLTLGGRNAAAGGSPLTKVRGGDASPDLFIEIRAD
ETVEITCHRSEMGQQVWTAMAQIIAEELEADWERVRVVQAVGHPRYGDQNTDGSRSVRYN
FHRLRVAGGALRTMLERTAAKRWKVAPSSCRAVLGKVTHPATNRSISFGELAADARAQPI
PTEGEIVLKKRADWRYITKPVKSLTVPRIVRGEGTFGMDVQLPDMLVAVIARPPRVFGKL
KRVDDSQTQLVSGVVETVVLDTPTPPAHFQPLGGVAVVARNTWAALQGRKLLELEWEAGP
NASYDSETYAQELMAKVREPGEVRRKRGDVAAALESAAERVAAEYYVPHLAHSPIEPPVA
TAKWDGDEVTCWACVQAPQAARKAVARVCEIPEDNVTINVTWLGGGFGRKSKPDFVAEAA
VVARAVQAPVKLVWTREDDLTHGYYHAVSAQRLEAGLDAEGRCVAFLHRTAFPVIDSTFE
AGADQPSWGELRLGASDTPFAVPNLQLETGRADAHLRIGWLRSVCNIYHAFAVQSFVAEL
AHAARRDPKDYLLTLIGPPRHVDPNKEGAEYDNYGSSLDDYPIDTARLAAVTTTAAAMAN
WARPLPNGHGLGIAAHRSFTTYVATVVEVAVDEEGRLAIVGVWSAMDAGTVVNTNHARTQ
LEGGTLFGLSNALYGEITAKQGIVEQHNFPAWRVMRMNEAPRHMETTIIESDAPPGGIGE
PPTPPAAPALTNAIFAACGLRIRRLPIFGPDRRDRLAVKGVKQ
>A0A1D8AY30|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lacunisphaera limnophila|TrEMBL
MPTYTLKVNGQAHTITVAADTPLLWALRDSLNLLGTKYGCGMGLCGACTVHLNGVPVRSC
QLPVSAIGNTPITTIEGLDPAGAHPLQKAWCDHDVPQCGYCQSGQIMSAAALLKQTPSPT
DADIDAAMAGNLCRCGTYVRIRAAIKDAALMAAKGAQS
>A0A5P9PBN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. YIM 10|TrEMBL
MATPTTNESGQETGSGFGRRGFLAFLVAAPTLTIAADVAIDQQAEAQLPSLPGPADIVDL
GDVLILAGTPTSHMLVLEVAEDGRIRLQLPRAEVGQGITTAVAMLVAEELGVPLSQVEVP
LSDARSELLFNQLTGGSNTIRSVYGPVRAAAAAARARLVTAAAEKFGGDAAKYTVRGGSV
VAPDGRKASFGSLTTAAAKVQRSAVGAEPKAESEHQLVGKPTSRIDALAMVTGKKQYTLD
LDVPGALPTVLKRPPTIRGTVKSFDDSAARAMPGVVDIVAIDSGVAVIAETFGQAINAKD
KLKVTWNKGTVDGLSDADIKKKLRAAALPFAVPPLLTQHVDAEFDFAFVSHAPLETNSAI
ADVRADRAEIWSALKSPVVAKQTIAAEIGLPENKVTVHVVQGGGSFGRRLFFDGALEAAK
VSKKAGRPVKLMWTRIDDMRHGRARAATHHKVRATFALGNVLSYEHRVASIETDFRHGLG
EILTATAASLPVGGNLSFAQTVFLTTVKVPYNFGVVTELLNEVPLPMNTASWRSVYSATT
RGAEEIVVDEIAKKLGKDPYQFRRASLKDDKQRAVLDKVAEAGKWGKKMPAGFAQGIAFH
EEYKSRTACLVEIDARNPKKPRVTKATIAVDVGRPINPRGLEAQMLGGLTDAISTVLTAG
LHLDKGLPLEGSYSQFHYARQKDIPQDVQVFVMPANGEPGGAGELGLPAAVGAVANAYAR
ATGTQPRSFPINFDVDFEPFPR
>A0A7W9TXD7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bannensis|TrEMBL
MVEIVINGQHHQFDGDPEMPLLWYLRDELGLTGTKFGCGMALCGACTVHLDGQPARACVT
PVGAISGRSVTTIEAVHEQKVGAAVQAAWIEKQAPQCGYCQSGQVMSAVALLKTQPNPTD
AEIDDAMSGNICRCATYQRIRAAIHEASEALKHA
>S7WYS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cyclobacterium qasimii M12-11B|TrEMBL
MANYKLKVNNKNFEVDVDSDTPLLWVLRDNLGLIGTKYSCGISQCGACTVHLNDEAVRSC
GLPVSSIGDAKITTIEGLSDNGDHPVQEAWKEVDVAQCGYCQAGQIMTAAAMLKKNPSPS
EEEVIDGMNANLCRCGTYHRIKEAVLLASAKIK
>A0A1A7C4V2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium psychrotolerans|TrEMBL
MTANTSTARRRFLLKGLGLGVAGVGALVLGWGVLPPRQRLHGSSPLPVKGGAVALNGWLA
LQADGTVLLAMPRSEMGQGVYTALAMLVAEELDVPLASITLVQAPMDKIFGNVAMLVDGL
PFHPDDNGRLKQLAQWTVAKAARELGVIVTGGSSSVKDGWQPMREAGACARAMLVAAACA
QWSATVAQCRTQDGEVFHADGRRASYASLASRAAVLDPGQPVLKSPAQFRLIGKAVARRD
TPSKVNGRAVFGIDARPPGMLYAALHLPRRLGDTLSSFDAPVALAMPGVKKVLDLTPALG
QHRISCAAVVADTWWRAKQAAATLPTQWRAGAQSHLSSAEVFADFARLLDAEAGHVYHAS
GEVDGKHVQALRQVTAEYRAPFLAHAAMEPVNCTAQVKDGKVHLWASTQAPGIAVDVAAK
VAGVASGDVTIEVLLLGGGFGRRLEVDMVAQAVAIALQCEGAPVQLIWTREQDTKHDMYR
PAALARFVARLDAQGRIASWDNQSVSASITHQYLQRNFGLPGMGPDKTTAEGEFDLPYEI
ANQRIAHVIADSSVPVGYWRSVGHSHNAFFKESFVDELAHAAGQDEVAYRRAMLQHHRRH
LAVLDAAVARAGSAPASHAHGVALHQSFGSIVAQVAQVSLENGEIRVHRVVCAIDCGLAV
NPNIIAQQMESSVLFGLSAALGGEITFKDGKVEQGNFHDYPVLRMGQAPEVETIIIASAA
HPQGVGEPGTPPIAPAVANAVFKLTGKRLRSLPLRLG
>A0A5E7WC76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATSALVLVASWGWQDAFAAEKEKKFGADGMPNGWIDD
PKVYVSIAADGMVTVVCNRSEMGQGVRTSLTMVVADELDADWAMMKVQQAPGDEVRFGNQ
DTDGSRSMRHWFEPMRRCGAAARTMLEQAAAEQWKVPVSECHAQLHKVIHKPSGRELGYG
ALAAAAGALAVPARDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAIYGADVHFDGMLYA
TIARPAVYGGKVKSVDSSAAMKVPGVIKVVQIEGHPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKEIEAASLKPGKVVRNTGNIDEAMGSADSTLEASYYLP
HLTQAPMEPMVAIARFKDGVCEAWAPSQAPQVTRERIGERLGIPFDNVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAIHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTARM
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAQA
>A0A5E7MFD8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVTTIDNLHVDPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7PLC8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVVGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVIGQNVSTIDNLHADPVGQIVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7U6Z3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSLVDDTRIELPRRVFLKQAATVASGLAIALYLPSGIAATDPKAPAPASEFEPNAWVRIF
PDGTVKLVVHKHDSGTGTQTVLAACVAEELDVNPMTVQVITPEDPFFETYIHPVWKVFST
GGSTSVSLEYERLRLAGATARALLITAAAKQWKVSPDSCVTEEGRVVHTASQRRLGYGEL
VAVAANLPAPTNVTLKDPTQFKYIGKLRHKRDAAAKVCGRFKYSIDVQLPDMLVAVIQRA
PVVGAKVLSVDSAAALKVPGVRKVLAIAGRPDVLGGNLEGVAVLADTFWAAQQGRQVLEI
KWSDSPLAGFDSEQLASAQARAIGDPEAQTVKAMTQGDVAGQWAGAAQLIEADYTMPYKV
QNPLEPICITAQVKDKAITYWGGVQVPSSALEAAQTVCGIDKANVTIHELVSGGSFGARE
AKYWLFEVAYLAQKTGVPVKLLNSREDEMHALFNHPATLHRVKGALDAQGKLSALQLHAV
SPASPEQWEPGYFERPDKMDYSTTEAITAWDFAYRPPHLELNWVKHESNVPSGWYRSVSF
IPNVFAVESFMDELAHAAGEDPLAFRLANMQERPRHVAVLKQAAERAGWGKPLPPGTALG
IATNQGYTSFIAVVARVTTVDGKPKVEKLTCVVDCGLAVSPGGVEEQVYGGLMWGFGHAL
FDRLDIKQGRVVQSNFHDYRVTRMSDMPATDILVLDGEPSKPGGVGELGSPSVVPAIANA
LFALTGVRQRSTPLNLG
>A0A5E6UXX0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATSALVLAASWGWQDAFAEDKEKKFGADGMPHGWVDD
PKVYVSIAADGTVTVICNRSEMGQGVRTSLTMVVADELEADWARVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARAMLEQAAADQWKVPVGECHAQLHKVIHKPSGRELDYG
ALAAAAGALAVPARDSLRLKQPSEFRYIGKEGTKAIDGEDIVNGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSFDGSAAMKVPGVVKVLQIESRPLPLEFQPLGGIAVVANNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNIDEAMTSADSTLEASYYLP
HLSQSPMEPMVAIARFKDGACEAWGPSQAPQVTRERIGERLGLPFDNVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNIRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFIDELAHKAGQDPLKYQVRLLGPDRQIDPRTLSEEWNYGESPERYPIDTARL
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLVVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAMLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLSGWQKAEA
>A0A0M7A6X4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium alexandrii|TrEMBL
MTKFILNSRPVEYTNPPEEMLLLILRDTANLKGTKYGCGTAMCGACTVHVDGEAMFSCQM
SLADVEGADVTTIEGLSEDGSHPVQKAWIEEQVPQCGYCQSGQIMRAAALLAENPQPSRE
EIVDTMSANLCRCGTYNRIFKAVERAAKEA
>A0A3S4PX46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MKRSFPDDLVIGNLSRRGFLKGVGATGVLLVAANWGWRDALAAEKKAFGADAMPHGWVDN
PKIYVSIDRDGTVGIVCNRSEMGQGVRTSLAMVVADELEADWSRVKVIQAPGDEARYGNQ
DTDGSRSMRHWFEPMRRCGAAARQMLEQAAANQWKVPLGECRAEQNKVLHAPSGRSLSFG
ELAEAAAGLEVPARDKLLLKKPEQFRYIGKDVARAIDGADIVNGRAGFGFDARFDDMLYA
VVARPPVYGGKLKRYDAAAALKVPGVVKVIEIEGRPIPSEFQPLGGVAVVAQNTWAAIKG
REALVVEWDAGVNGGYDSAAYRKQLEEAARKPGKVVRDSGDAAALFAKGGDIVEAEYYLP
HLAQAPMEPPVSTAWYKDGACEVWAPTQAPQVTRERIAERLKLPFDKVTVNVTLLGGGFG
RKSKPDFVLEAAILAKAFPGRHLRVQWTREDDLHFSYFHTVSVERLQAVLGADGLPQAWL
HRSVAPSITALFGPDSKHQGAFELGMGLTNLPFAIPNVRLENPEAPAHTRVGWFRSVSNI
PHAFAIQSFVGELAAKAGQDPKDYLLKLLGPARRIDTAELGDSWNYGESPERYPLDVGRL
RGVIEEAARQSGWGGELPRGRARGIAAHYSFVTYVAVVIEVEVKDDGALLVHKATIAADC
GPQINPERIRSQLEGACVMGLGLAALGEISFKDGKVQQDNFHQYELARMPLAPKAVSVHL
LKPDGDLPLGGVGEPGVPPIAPALCNAIFAATGKRIRELPIRNQLQGWRKA
>A0A5E6R149|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHHLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVTTIDNLHADPVGKVVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPSD
AQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEVKA
>A0A5E7P5W8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLNDIFSQELPRSLQHLLERDQADGAFTLPRRSFLKIVGIGGLALGAFPHLALGQEAAGG
DAALLKPSQQPSAFVQIDSSGQVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
NNNTAYQDPVFGMHLTGGSNSIKNSYTQYRELGARARAMLLAAAAARWNVEVTRLSTQAG
MVLGPAGLKASYGELAEAAMALPVPDKVTLKDPRDFRIIGQATTRIDAKAKSSGQQDFGI
DMHLPGQLTAVVARPPVFGAKIASLDDSAARAIKGVKAALRVPLDGGAEGVAVIADGYWQ
AKLGRDALKLQWDLATVEKVDSEQQLIQYRALAGQPGLVHFDADMAPLATAKHQLEAEFV
FPYLAHAPMEPLNCTVQISDKSAQLWVGTQFPGGDSAAAAKVLNLKPEHIQINVQTAGGG
FGRRGVPTSDFIVQACEVAKAARSVGLNVPIRTLWSREDDIKGGYYRPMHLHRARIGFDD
SGTVVAWDHVLIGQSILTDTMFGGQIKNGIDPTATEGMRDPYPLPMRLTVHHPKLNVPVL
WWRSVGSTHTAFVMETLLDEIARTTKQDPVAYRMKLFGEQSPRHREALQLAVDKSGYGKR
QLPAGHAWGVAVHECFSSVVAYVVEASVQNGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
ALMGLSMCLPGNAITLKDGVVQQSNFADFSVPRITDMPEFAVHIVPSAEPPTGMGEPGLP
ALAPAFANAIASLTGKPIRVLPFKLT
>A0A5E7I3V7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIEFTVNGERHELVETSPSMPLLWVLRDHLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPVAAVAGHSITTIEGLSATEQHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
DSIRNAMSGNLCRCGTYGRINKAIKRAASASKEA
>A0A5E7U2D1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSINTISRRGFLKGSAMLGGGLVVAFAMPGAHRFAMGAENQGNVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWTKIRVEHAPASAADYGLPGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIHTESGMVIAGEHRATYGELADDAGQL
PRPDPASITLKDAKDWRLIGKPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPTFGG
SVKSFEGAEALAIPGVHKVVQVPTGIAVIADHFWAAKLGRDALKIEWNPGPNAGLDSQSL
LESFRKLATTPGINAGQAGDTQAALAKATKKIDVEYSVPYLAHAPMEPLNCTVSITQDKC
EIWTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVSEAVYVAKAAG
APVKTVWAREDDIRGGYYRSAFLHHARIGLGADGLPLAWKHVMVGQSIMAGTSLEATMVK
DGIDKTSVEGVADSPYFEGLANHQIELHSPKTGISVLWLRSVGHTHTAFVMESLIDELAT
AAGKDPVEYRRTLLKDHPRHLGVLNLAVERANWTAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESGIAFGLSFALHSKLTLKDGQVVQSNY
HDYQVLRLNEMPVVEVHIMPSSDKPGGIGETGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A7W9ARD0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas yantingensis|TrEMBL
MTDQANGPRGFAMTRRRLILGGSLAGGAMIVGYAATHPAEIGGAILSGGGKDPPESAFGA
FIRIDPDGQVTIVNRQQELGQGIHAGIAAIVAEELDADWARVRVIDARSNFRAYGLQGSA
GSNSIASNWDLMRAAGAAARSMFVDAAALRWQVPRRLIEVRDGIVFHAASNRQATFGELL
ADAARQTPPQTPRLKTPDAYRLIGTDRVRRKDSLPKSTGAQRYAQDVRHPGMLIAMVAHS
PRFGGRIARYDVSDAWRVKGVVDAFAIETGVAVVAETTIAARRGREALRIEWDDRAAEKR
SSADLQRQYHDIAEGRSDLSPEDFAMRGEGAAPAADAIEFAFDFPYLAHAPMETLDCVAQ
VNGWNVKLTSGSHLPIVDQVQAARAALTLPGKVDVEVVPAGGSFGRRGILPADYIVEAVR
IARRTRGRPVKLIWTREDDLTGGYYRPMSHHRVAVALGADGLPDQWCFRSVCQALLPVGG
NAQAVEGMADSPYLSTARTIDGKLYTPDIGVPVSFWRSVGHSHSAMVMEHVIDQLARRVG
RDPAAYRRQLYVRAGATRRIEVLDTLCEKGGWGRPIEAGWARGMAVHEAFGTTVGQIAEV
RMDGGRPVVRRVVAVVDCGIAVAPDQIRAQMEGGIGFGLSAALHGKITLRDGIVEQTNFD
THPILRMSEMPAVETHILPRTTPPTGMGEPGVPPIAPAVANAALVLTGRATRGLPFAVG
>A0A2C9EIX1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MNRLPQDFALSNLSRRGFLKGVGATGALVLAASWGWQEAFAEAKKFGADGMPHGWVDDPK
VYVSIASDGSVTVICNRSEMGQGVRTSLSMVVADELDADWAQVKVRQAPGDEVRFGNQDT
DGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWQVPLAQCRAQLHKVVHQPTGRELGYGAL
AAAAGALAVPARDSLRLKQPGEFRYIGKEATRAIDGQDIVNGRAVYGADVHFDGMLFAAV
ARPRVYGGKVKSVDDSAALKVPGVIKVMPIDSRPLPSEFQPLGGVAVVASNTWAAIKGRD
ALRIEWEDGANAGYDSIQYRKQLEAAARQPGKVVRSTGNLDEALKGAESSLEASYYLPHL
AQAPMEPMVAVARFQDGRCEAWAPSQAPQVTRERIAERLGIGFEQVTVNVTLLGGGFGRK
SKPDFILEAAILAKAFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGLNKDGLPAAWLHR
TVAPSITALFAPGMNHEGAFELGMGFTNMAYAIPNVRLENPEAAAHTRVGWYRSVSNIPH
GFAIQSFVDELAHKAGQDPLQYQLKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRLRT
VLETAAKAAGWGRSLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHQADIAVDCGP
QINPERIRSQFEGACVMGLGNAVLGEISFKEGKVQQDNFHMYEVARMSLAPKQVQVHLVT
PPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQQASA
>A0A6J5ETM9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia solisilvae|TrEMBL
MRVTPHSMERVVSRRDFLRAGLSVGIAASGGLLLGVSFNARSDGGPAPASVIAGDGSLQI
PPGEFAPNAFIRIDPDGNVALVVSKVEMGQGVYTSIPMLLAEELEVPLERVKVEHAPPDA
KLYADALLGQQATGGSLSIRAMWEPMRRAGAAARMLLISAAAQQWQVDPASCVARNATVT
HTASGRTLGYGELAPHAAALPVDANLLKTVTLKKPQAFTLIGTPRKRLDSPEKVNGVARF
GIDVQMPGMRVAMVVHCPVIGGKLARVDDRVALAQPGVRQVVKLDNAVAVVADHTWAAKR
GASALVIEWHEGANAHLTSAMLFDDLRRASEQPGAAARTDGDVDAGFKAAAQKLDAVYQQ
PFLAHATMEPMNCTVHVSGDQCEIWIGTQVPTRVVDVAVKVTGLPAEKIVVHNFLIGGGF
GRRLESDVAAQAVAIGKQVDGPVKVMWSREEDIQHDMFRPCYYDRVAAGLDANGKPVAWT
HRIAGSSIVARWFPAWFQKGIDPDVIEVAAALPYAIHSQRIDYVRQEPRGIPTAFWRGVG
PTRGTFVVESFVDELAHQAKADPVEYRRALLGNTPRARNVLDVAARAAGWGTALPQGKGR
GVSVMHAFGSFFCMIADVDVKDGDVRVERVVCAVDCGHVVNPNTIEAQVEGGAIFGITAT
LWGEITLKDGRVEQTNFTDYRVMRINEAPRIQTIIVRSDEDPGGIGEPGTSAVIPAITNA
IFAATGTRIRRLPVGDQLHSGQTA
>A0A095B0H3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter tropicalis|TrEMBL
MVNGLFDDAPLMQQGPVNLSRRRFMLTSAGAATGAFVLGFGLPARQARAQAAQGPKYRGT
QVPAFLEIRPDNTVRLQSPFIEGGQGTFTAMAQIVGEELDADPSTFLVENAPAGDEYAVM
DSGMRITGGSMSVQNGYPAMRRLGALGREMLLQAGAQHLGVPVSELTTLPGQVVHAASGR
TVTYGELAPVAMDLPVPDPASVKLRDPSQFRWIGKSVKRLDIYEKSTGKVDYAIDVRVDG
MLHAAVQHAPRLGMTVGSIRNEEQVSQMKGVHSVHRLPGAVAVVAERWWHARRGVEALLV
NWVEAEPGAASDIRVMPADFSTEEFRKHLATVSGKEENAETKGDVTRGLKNAHTVVEATY
FSQYVNHGQLEPPSALARYNPDGTLDIWLPNQAPDMFRADMARRTGMDAEKITIHSPLLG
GFFGRHFLYDHGSPYPQAIALAKATGRPIKLIWTREEEFLRDALRPMAAVRFRAGLDATG
RPVALDVVSATEGATEGLGTKRGKDLDPTALEGLTNKAYDIPDRRIAQLFVRNPATLGYW
RSVGNSMNDFLYETFLDELADKGHQDPYELRLHLLRDNRRLTTLLKAVADLSGGWKRGPF
TAADGSRRARGIGMASPFGSEAAAIAEVSIENGRVRVHEVWEAIDPGKVVNPAIVEAQVN
GAIALGLSQVLLEETVYENGMPRARNYDGYPILALNQMPRVHVKIVESGEKMGGVGEPPL
PAIPPAVANAVSTLTGRRIRSMPLSRHDFAS
>A0A292YPI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. N23|TrEMBL
MAHHRLASPPKETGLHRSVGRRKFLGYLIAAPTLVVAAELGREQIFGAPEASAAALPSAP
QTPEVYDLLDALRDAARPTANLIRVEVNRDGTVSFALPRSDNGQGIVTSTQMIIAEEMGL
DVDQVRVTLADARPELLFNQITGGSSTTFTTYTAIRVAAALAQGRLLEAGAQLLAQDVRT
VTSRKGLILGAGGRSVPFSALAEKAASATTEQVEVTLKAREEFTVIGKPHNKTDARDIVT
GRKVFATDLKIPDALPTVICRAPDLNGTPDDVDNLDDVRSMPGVTDVEVVTTGVAVRART
FGQAIDAVNALQVSWNRGTVAGEDDESVLRRVRAAELPMAVPAGVGKTVDRAFTFYFASN
SSLETNCCIADVREDRAELWGPMKNPIAAQGDIAKIVDLPISKVTVHVTQGGGSFGRKLF
YDAALEAAECSKAFGKPVKLMWTRADDSRQGRVHPLSTSRVRAQVGADAVLSYEQRHTSV
ATQINPGFGEPITAAAVKAPLGNLTLSESIFELTQVTPYEFGVSTRLLNEVDMRFNTSAM
RNIYSPNVATARELMVDELAATMGKDPYEFRREFLRGERLRAVLDAVAKEGRWGRSMKKG
TAQGLGVHTEYKAATAALVEIDCRPETVDRPIREGVTGPRVTRVTFAVDVGLVINPRGLE
AQMMGGINDAIAMILTSSLHLTDGHFVEASWDNYFYTRQWNTPPELNIVLVESDAPEPGG
AGELGLSAACGAIATAYARATGTVPEYFPINHRDPFPFEPKPLVPPIPESPTDGLDHTY
>H0T533|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MSIIANPDTAKSNPRRGFERHLKVENVSRRAILQTLGLAGGFVLAAPLLSRPAFAAYETG
AGKMPHGTVVDPKVFVSIAPDGIVSILAHRSEMGTGVRTSLPLIVAEEMEADWSKVRVVQ
APGDEVKFGNQDTDGSRSTRHYLLPMRQIGAMARAMLEAAAAQKLGVPASEVKAVNHEVV
HSASGKRIGFGELASDAANQPVPAVDSIKLKSPRDFRYLGKGQVSIVDLRDITVGKARYG
ADVRLPGMKYAVIARPPVTGGKVKSFDAAEALKVSGVEQVLEVKGWPWPSKFQPLGGVAV
IARNTGAAIKGRDALKVEWEDGPNAAYDSVAYRADLEAAARQPGLVVRQEGDADAALKSA
DKVITGEYYLPHFAHASMEPPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLQIPPENVT
VNVTLLGGGFGRKSKCDFALEAALLSKTLGAPVKVQWTRDDDIQHDFLHTVSVERIEAGL
DKSGKVVAWRHRSVAPTILSTFAAGADHAAPFELGMGLVDMPFEIANIQCENPAAKAMTR
IGWFRSVSNIPRAFAVQSMVGEIAAATGRDQKDMLLELIGSPRVLKLASVKDLWNYGEPY
ESYPIDTGRLRRVVEFVAEKGNWGRSVPKGHGLGIAAHRSFVSYIATIVEVSVDDKGKLT
VHQVDSAIDCGTFVNPERIASQLEGAAIMGLSLAKYGEVSFKNGRVQQRNFDDHPVVRID
EAPLVTNVHIVPADADTPPSGVGEPGVPPFAPALANAIFAATGKRLRALPIGNQLAT
>F3BET5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas distincta|TrEMBL
MITLTINGNKHEFSGDPSTPVLWYLRDELNLTGPKFGCGMAQCGACTVHIDGVAQRSCVL
PVAAVAGLSITTIEGLSEQGDHPVQQAWVEHKVPQCGFCQCGQMMQAASLLAANPTPTDD
EIVSNMSGNICRCGTYPRIHKAIKSAAKTMASVQYFDPNEQGEEV
>A0A087PMA8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MIKFKLNGRDVSVDVPEDTPLLWALRDELDQTGTKFGCGVGQCGACTVHVGGRATRSCIT
PISSIEGAEITTIEGLHPEGEHPVQQAWRDIQVPQCGYCQSGQIMQAASLLKDYPDPTDE
EIDGVMGGSLCRCMTYVRIRKAIKKAAAAMREEKSNG
>A0A1X1PLH7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia puraquae|TrEMBL
MTIELDNTGAVRPSRRTFLKAAGAAAAVSLTIGFEWAGLGRRALAATAPAAGFAPNAFLR
ITPDGAVTVIAKHVEMGQGAYTGIATIVAEELDADWSHVRVESAPADAKRYANLAFGTMQ
GTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWKVPAGELTTANGVVTHAKSGKTAAYG
TLVADASKLPVPDQVTLKQPADFKLIGHQIPRVDASAKSNGTAHFTLDTTFPGMRVALLQ
RPPRFGAKVKSFDATAAKAVPGVVSVVQVPGGVAVVGTGFWAAKQGRDALKVEWDETNAE
KRGSDEIMREYRQLADKPGTSARKDGDADAAIAGAARKISATYEFPYLAHAPMEPLDAVV
KLTANSCEIWAGDQFQTVDQANAARTAGLKPEQVQIHTLYAGGSFGRRANAWSDYVVEAV
SIAKALGADRKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGKLVGWRHRIVGQSILA
GTPFEAFMVKNGVDATSVEGAANLPYAVPNVSVELTTTKVGLPVLWWRVVGSSHTAYAVE
AFIDEAAHTAGKDPYAFRRDLLAKEPRMRAVLELAAQKAGWDPAKPLPKGRGRGIAVAEA
FKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIVAAQMEGGIGFGLGAAMHSAIT
LKDGQVEQRNFDGYHVLRIAEMPKVEVHIVPSAEAPTGVGEPGVAPIGPAVANAIFAATG
KRHYVLPFDSADSAKA
>B1FTW7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)|TrEMBL
MTTDLDLPDAVRPSRRTFLKAAGAVAAVGLTIGFEWAGTGRRALAATAPEAAFAPNAFLR
VAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWQDVRVESAPADAKRYANLAFGMQG
TGGSSAMANSWMQLREAGAKARAMLVSAAAAQWRTPASELTTRDGSVHHAATNRTATYGS
LASAAARLPVPDKVALKSPKDFRLIGHQAPRVDVPPKTDGTAQFTLDVTFPGMLVALLQR
PPLFGATVRSFDASAAKAVPGVVSVVQVPGGVAVVAKGFWAAKQGRDALKIEWDDSKAEK
RSSDAIMAEYRQLAEQPGASARKDGDATQALAGAAKKISATYSFPYLAHAPMEPLDAVVK
LTADSCEIWAGDQFQTVDQGNAARTAGLDPQQVKIHTLYAGGSFGRRANARSDYIVEAVS
IARALGANGTPVKLQWTREDDIHGGFYRPMYFHKLDAGLSADGKLVGWRHRIVGQSILGG
TPFASAMIKNGIDATSVEGAANMAYAIPNISVELTTTQTGVPVLWWRVVGSSHTAFAVEA
FIDEAAHAAGKDPFVFRRDLLAHEPRMRAVLELAARKAGWDPAKPLPKGRGRGIAVAEAF
KTFVAQVAEVSVDKDGNVKIERVVCAVDCGTPINPDIIAAQMEGGIGFGLGAVLHSAITL
KDGKVEQNNFDGYQVLRIAEMPKVEVHIVPSGEAPTGVGEPGVAPVGPAVANAIFAATGE
RLHSLPFPAAAKKSA
>A0A0D6HV35|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MEHTAATAPAADPIDLKVNGAAARVAVAPATPLLLVLRNDLALNGPKYGCGLGECGACTV
LIDGVAARSCVIPVRAAQGREVTTLEGLGTRERPGPTQRAFIECQAAQCGYCLNGMIMTV
EALLRRDPAPSERAVRSELHHNLCRCGTHVEIMQAALRAVQLRAAARPCGPEGAGA
>A0A484QKI6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MSGAVMQGRLPAGLDGAMPPAAALHGVVSRPPRMAWDGRRYTGPGLARLDDAAARAMPGV
VDVVRIAHFVGVVAVSAVLARQAAEMLAPQWRSTGPVPATPPEDAPEAAAQTYTWQLPAH
PCVEGLSVTVWCVAGVAGVWLPGGGERHASLRAELAGLLDLPGDRIHLASAGSCIVHDLD
VMDAAADAALLSRAVGRPVRIFLQQPAEAGALSLAAQPMMPAAQDPQAPSGEAAPLASEP
PAACLHANVHWGVRPSLARLLATPAQAAASARSAAQGDPAIVSASTGGALVHASSTELGA
MQVFAQESLLDEAAARLGADPLAHRLSVAPPGPGRELARRLAEQSGWQALPSGAAGAMAL
DQRLSAQDGMPALRGRGYASAHVRTGDIEGGTQDSWSAWVVEVAVEPDTGRVDVTRLVVG
HDSQHLQAAQGAAIHEQPPQLLDSARRLLGVPARFDDWGATAAGGAAPLALAEAGHEMVH
AQRDAQEVRTALAQPPVAQGRLAADGVLTLPAAAAIANAIFDATGVRLRQVPFNSEQLRQ
ALLPSRPRASPRAWYKRGGLWLAAGAGAVAGLVTMAWPGKPAIAPTDGPDVSLYSDAAIE
RGRLVAAAGDCVVCHTAPKGEANAGGLGLETPFGTIYTTNITPDNDTGIGRWSFSAFDRA
MREGVHRDGRQLYPAFPYSAFAKLTDADMQALYAYLMVQPPVRSEPPKTELAFPYKLRPT
LAGWNLLFHDNSVYQPDPAQSLAWNRGAYLVEGAGHCAACHSPRNALGAEKRGLGSYLAG
GEAEGWTAPALNQLASGATPWTADELFQYLRTGYSARHGVAAGPMAPVIHGLAELPESDV
RAITTYLLDLPGGKAAGGAERKEAPAPAPAMSAATDALPAAAARQPDAQRLFVNHANGER
IYQNACAACHETGSGPTLFGVKPSLASNPNLHAETPDNLLQVVLHGIQQPANEELGYMPG
FKDSLDDRQVQDLLGYLRARFAPQARPWQDTEPAIDRIRKQAH
>A0A5B7V7N7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. YIM 121038|TrEMBL
MRSRSRATGAAGAGVEPQGAAGPGGEGVGRRRFLGFVLAAPTLVTAAELGAAPAAEADIT
ELVDLNDVMTTAALPTSNLITVEVHADGTVSFALPRAEVGQGITTSTAMLIAEELDVPLE
RVRVTLADARPELVFNQLTGASNTTISTYLPIRVAAAVARERLLRAAAAELRAPLAGLTL
RAGTVTDGAGTAIGIGALAAKAASVTVRRAWVDLKDRADFTVIGRPHNRIDALAAVTGRK
KFAMDLDVPGARPTMVCRAPTINGRVGSVANLDEVRAMAGVTDVGVVSTGVAVRARTFGQ
CIEAVRALRVAWRPGSADGASDESVLQELKEAELPLGLPALTPSVEARFTFHFRGNSALE
PNCAIADVRADRAEIWSGLKAPIVAKQAIAARLGLAPGAVTVHVTEGGGSFGRKLFLDAA
LEAAEISQTFGKPVKLMWHRADDARQGRAHPMATSRVRAAYAGGTVLSYKQRHTSVATDF
GHGLGEVFTALAAKLPVGDAAFSQTFFHLTQSMPYDIAVHSRLLSETNKGFNTGSMRGVY
SPDVVCARELIIDELAAKTRQDPLALRRGLLREKRFRAVLDKAAEAGGWGRPMPAGTAQG
IAFHGEYRSASAVLVEIDCRPETVNRPVRDGVSGPRVTKAVVAVDVGLAVNPRGLEAQMT
GAVMDGIAQVLTSSLHLREGHFLEASWDNYFYTRQWNTPLELKVLLMPSAGGEPGGAGEL
GVAASMAAVACAYGRATGTMPTRFPVNHGTLSFTPKPTVPPVPASPTDGLDHVR
>A0A484S652|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPGT
PAGWRALAFNGHVDLGTGIRTALAQIVAEELDVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAARWQVPATALRARAGRIVFADEADTRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGALTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREI
PPAPDLGDLEAALRANRAEPRHLRDDGNTAHALATTPDTRRLRRSYVWPYQMHASIGPSC
AVADHANGRLTVWSGTQNPHMLRVDLDRLLDLGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLVDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGRVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGSDGLLHG
RGVAYARYIHSKFPGFGAAWAAWVVDLRVDPDSGHVTIDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPEIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRNALLARKQPGMPRADAPLSDTQPA
>A0A1C0XH06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia pickettii|TrEMBL
MVTLNINGKPVEVDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAVAGQQITTSEHIADDKVGKAVLDAWVKHDVAQCGYCQSGQMMSAVGLLRTKKKPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAAKSLA
>A0A1S9GYW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium laguerreae|TrEMBL
MARFLSRRGFLITGAALGGTALVAAVGGVGYLATVDVDGLHGHLNGERAALNAFLIIQSD
GRVVVNVPRTEMGQGIHTGLAMVVAEELDIPFDDRITVEFPTEAHPAYSVWFNMLQIRPE
EASGPVVWVGRRVLGQLGFIATGASGSTMGMWHPMRVAGASARYMLLAAAAARLDVPAAE
LATGDGFVQHVSSGQRLSYGELAREAALLPPPDRPALKPASEWRIIGRSQPRVDLPAKVR
GEPVFGMDIALPDMVHAAIRHAPVFGAKVGRVVNEAEVRAAPGVHDVAVIEGQKVAVVAA
SWWHAEQAAWLLDIEWTKTDADGVSSTEMSARLRSALASTTPYEHIDDGDANSVITNAST
VVKAEYTVPFLPHACMEPINATVLVRDDLTAETWVSSQSPMAVRQGVARGAGLAGVEPTS
VTCNITMNGGAFGRRSDQDVVAEAAFLAARHRGRPVKLIWSREEDIACGLFRSHAAARLR
AALGPDGLPVAYDALVATQSVIESIASRNLPVNPGPDGDRISVEGLDKLHYAVPNRRIRS
QHVPSHMPIHFWRSNGFSFNTFFTESFIDECALAARADPLAYRRALLRGSPRHLAVLNRV
AELAKWGTPMAPGRGRGIAIEECYRSVVAQVAEVTVAADGEIRVDRVFCAIDAGLVINPD
AVIAQMEGGISFGVTTALMSAISLDGGAVVESNFHDFPMQRLANAPAIEVAIVDSGLPPG
GAGEPGIVPVAGAIANAIHAATGRRIRSLPLAVTETVDERRTRTVLPPAAT
>A0A1E3ES96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MANLKINGKTITVDVEDDTPLLWAIRENVGLTGTKYGCGIAQCGACTVHIDGVAMRSCGV
TVSEAAGKEITTIEGLAAGGVMHKVQLAWIASDVPQCGYCQSGMIMAVAALLKDNPKPTD
DDINDAITNICRCGTFQQVREAIHAAANA
>A0A0T5PBK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius indicus|TrEMBL
MTAMQRQPRRPLNVSRRAFLAGTGSLVLTTTLPARQGRAQEAAGAQPPDVQAFLELRQDG
TARLLSPFIEGGQGIFTALAQIVGEELDLAPSQFTVESAPAGNPYGLMGGFRLTGGSAST
RTSYPIMRQLGASARAMLIEAAAQEWGVDASELTTEPGAVLHNASGRRAGYGELATAAMD
MPVPADVTLRDPSEFRWIRSPEPRLDIHEKSTGQAKYGIDVEVEGMLLAAVKHAPRLGLS
AGAVVNREDIEAMRGVHSVHVLNGAVAVVADRFWQARRAIDAMEVEWTEGDAKWPMPESF
SSAGFRDMLEAAQGEVVEVEARGDAEATLANTDTVIEAVYDAPFLVHGQLEPPSATARFN
DDGSLDLWLPNQAPEMFREAAATAAGIEPANVRINSQLLGGFFGRHFLYETSNPFPQAIQ
LAKAVGRPVKLIWSREEDFLRDAVRPLGLARFRGAVEPDGPTALVAEVVGEGPTGRWYNA
KPGSDASATEGISGKSYAIPNSRVGQLFQPNPAVIGYWRAVGHSMHDYMYECFLDELADA
GGQDPVEMRRRLLTGSDRLRTLLERVVESSGGWKRGPFEAEDGSRRARGVAMASPFGSEA
AAIAEVSIDGGEVRVHDLWIALDPGQIVNPAVIEAQVQSAAALGTSEALVEELVYENGEP
TARNFDMYPFLRPDQMPNVHVEIVESGAEMGGVGEPGLPAVPPAIVNAVSALTGRRIRSL
PLSKHDFG
>A0A1Y5TDM4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Oceanibacterium hippocampi|TrEMBL
MIRITVNGKPHELDVEPEMPLLWALRDELGLTGTKFGCGVAYCGACTVHVDGTPTRSCVT
GVGDVDGAAITTIEGIAGRDGDGAPLLHRVQAAWIEAQVPQCGYCQSGMIMAAVALLDSN
PNPSDAEIDEAIDNVCRCGTYQRIRKAIHLAAG
>A0A4P0VBW3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MNSKIDLSNALPGSRRGFLKGAAVVGLSIGFQWSGARRALAAALPESGFAPNAFLRIAPD
DSVTVIAKHVEMGQGAYTGIATIVAEELDADWNKVRVESAPADAKRYANLAFGTMQGTGG
SSAMANSWMQLREAGAKARAMLVEAAARQWRVPAAELRTRDGFVEHPASQRKASYGSLAA
AAAELPVPEKVQLKDPKDFRLIGHQAPRVDVPGKTDGSAQFTLDVSLPGMLVALLQRPPL
FGATVKAFDATAARAIPGVVEVVQVPHGVAVVAKGFWAAKQGRDALKVEWDESKAEKRGS
EALMAEYRKLAEQPGKPVRRDGDAAGALAGAAKKVAASYEFPFLAHAPMEPLDAVVRLTA
DSCEIWAGDQFQTVDQGNAARTAGLKPEQVKINTLYAGGSFGRRANAWSDYIVEAVSIAK
ALGANGVPVKLQWTREDDIHGGFYRPMYYHKLEAGLDADGKLVGWQHRIVGQSILEGTPF
AAMMVKDGIDGTSVEGAANLPYAVPNVSVELSTTPGRRTGPVVAGGRQLAHGLRGGGVHR
RGGAGRRQGSLPVPPRPAGRAAAPARRARTGRGKGGWDRPSRCPPGAGAVSRVTEAFKTF
VAQVVEVSVDKDGKLKVERVVCAVDCGIPINPDVIAAQMEGGIGFGLGAVLHSAITLKDG
KVEQNNFRRLPGAADRRDAQGRGAHRALRRSPHRGRRTRRGADRPGAGQCDLRRHRPAPL
PPALPHHLRQGLNQAPAGGPAAAGAAQATIREPPPTTPAAPASRRFASARRRAQTSTSIR
QRSQA
>A0A157SMC8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella ansorpii|TrEMBL
MDSHPVLPEHPIHNVSRRRFMPAAGGLVLGLNIGQAGPRGGAAGGAAQTAARSPNAFVRV
GQDGWVTVLAKHLDADQGAHTGLATLVAEELDADWRQVRVEGTPAHAGAGRSGSMAQSYL
PIRRAGAAARAMLVEAAARQWRVPASEIVIRDGIVRHPHSQRQAGIGHLAAAAAALPAPQ
DPALKAPAEFKLIGKEGVGRADNPGKTNGTAVFTQDFKLPGMLVAVAARAPRPGARLAGY
DGLAARGVAGVRAVVEIPATPQHPAVVAVLAENTWAARLGRDALQARWEDDPSHGQRHAD
PLAGYRAAVGQPGPAVMQEGDVDAAFARAASIIEADFLQPLAVQAAMEPLSCLVRLADRR
CDIWNGEPVDPADQAAIARYLKVPAGGVTVTALHAGGSNAGPRRGSQAGYLIEAVALARA
ARRQGLDVPIKLTWTPEDDLHGGHVRPMRLQRARLALDAAGAPLAWHVRHAGLSPQADPA
QAAARIDPPYAAPHQRLEQCSPPDGDPPAWHRPDGHAMAFAAETLIDQAALAAGQDPVAY
RAGLLAGQPRHARALALAAQQADWGRPLPRTIPNTRRGRGVALHAACGTVMALVAEVTVR
PCGALKVDRVVCAVDCGVAINPGVLRAQLEGGIGAGLANCLHGLPLTDSEAQQDRFHASP
VLRMDEMPRVEMHIVPSSDAPAAGVATVAADAVAPAVGNALHAATAQRLHALPFSTKMDI
SAPGVVPFLPPASIAARQQAYGAPPPGRSPGRRGADAEKRPQEHDTGALAA
>A0A157Q3F9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella ansorpii|TrEMBL
MLTLDINGRTTSLDVPAQMPLLWALRDVADLTGTKYGCGGAQCGACTVHADGHPIQSCVT
PTSAVRGRRIVTIEGVGADRVGQAVQHAWRELDVAQCGFCQSGQIMSAVSLLRRHPHPSD
AQIDQAMRGNLCRCATYVRIRAAIHHAAAALD
>A0A7W8LC29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia youngii|TrEMBL
MAVLNINGRRVLVNADPDMPLLWVLRCDLGMTGTKFGCGVGICGACTINLDDAACLACQT
PMSSLHTQKITTIEGLQGREAQALKTAWLELDVVQCGYCQSAQLMAACALLKHKPDPTDA
DIDEAMTPVVCRCGTYPRVRAAIHQAAAKARKS
>A0A3G7HD50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MTFILNGRRLLLDQLPPNTPLLYALRNDFGLNGPKYGCGLGQCGACTVLVDGVAARSCTL
PLSSVQGKQVTTLEGLAQQERLHPVQQAFIDEQAAQCGYCSNGMIMTLVALFEREPEADE
QRIKNELAYNLCRCGAHFEILRAAARARQLLAERGRP
>A0A3G7HA87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MITASRRGFLKGGALLGGGLVVAFVIPGANRFARAASEEFVPNAFLRIAPDGVVTVVLGH
SEMGQGIWTGLSMLIAEELDADWSKIRVEHAPAAAVYGLPAFGGMQITGGSTSTWMEFDR
YRQAGAAARQMLIEAAAKRLQVAPSTLRTEQGWVVAGDQRLSYGDLANDAGQLPVPDPAS
LKLKEAKDWRLIGKPTPRLDTPEKITGRAQFGMDMYFDGLLTAVVLRSPVFGGTLKSFDP
QAALAVPGVLKVLQVPTGVAVVAEHYWAAKQGRDALKAEWDLGPNANMSSESLMQSFRKL
ALTPGTQAAEAGDAAGSMAKATQVLKAEYSVPYLAHAPMEPLNCTVRIGADKCEIWTGTQ
FQTLDQMVAAKITGLKPEQVQIHTQFLGGGFGRRANPTSDFVSEAVEVAKAAAAPVKTVW
SREDDVRGGYFRSAFLHQAQVGLDAKGLPLAWQHVLVGQSIMAGTSFEASFVKNGIDNTS
VEGLADGPYLKGTPNHRVDLHSPMTGITVLWMRSVGHTHTAFVVESLIDEMAAAVGKDPV
EYRRTLLKDHPRHLGVLNLAVEKAGWGKPAPNGHALGVAVHESFGSYVAQVAEVSLEAER
IRVHRVVCAVDCGIAVNPQSIVAQMESGITFGLGMALHSRISFKDGRVVQSNYHDFQVLR
LNEMPEVEVHIVASSDKPGGIGETGVPPTAPAVANAVFALTGQRLRELPLQLAGV
>A0A3G7HCM6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MNKPIDFAEDLLDLPLDEPVNLSRRRFLTGAAVGALVLGFGLPLGSARVLAATATAAERG
TQVPAFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFVVEAAPPGEAYVV
MENGMRITGGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPLAELSTEPGRVLHAASG
RSLGYGELAGRALDMPVPDPASITLRDPSQFRWIGKPVRRVDAYEKSTGKALYSIDLKVD
GMLHAAVQHAPRLGMTVGSLRNEAQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEAIQ
VDWQEASADSPVRPMPADFSSDGFRDFLAAQQGPARDDENEGDVAAALASAKTRVEATYH
NQYLNHAQLEPPSALARYNPDGSLEVWLPNQAPDMFRADIARRTGLDPSRVTLHSPLLGG
FFGRHFLYDSASPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAVVKFQAALDAQGL
PVAIEAVSATEGPTEAIAGKQGEKLDPTALEGLSGKSYAIANKRIAQIYVKGPAMLGYWR
SVGNSLNDFFYEAFLDELADKGGRDPYELRQHLLRDNPRLTTLLQAVGELSGGWKRGPFT
AEDGSRRARGVAMASPFGSHTAAIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVNG
AVALGLSQTLVEEAVYVDGKPRARNYDLYPILPPSRMARVHVRIVESGEKMGGIGEPPLP
AVAPAVANAVARLTGQRIRSLPLSRYTFS
>A0A7W4W849|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Microbulbifer rhizosphaerae|TrEMBL
MQITVNGSAHKVEVEEDMPLLWVLRDELKLTGTKFGCGGGFCGACTIHLDGQPVRACLTP
VSFAEGKQITTVEGLSIYGDHPLQLAWIEHNVPQCGYCQSGQLMSAAALLQQTPNPDDKQ
IDQAMTGNLCRCGTYPRIKSAISAAAKMKAAAKIKRAAAKEGNADA
>A0A7W4W8C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Microbulbifer rhizosphaerae|TrEMBL
MPDTTVKNIHRRQFLKLTGLSAGGLVLGANLPGWQPAWAAGLEKNSELNLFVSIDSDDTV
SVVCHRSEMGQGIRTGLSQIVADELEADWQKVNVVQGLGDKRYGDQNTDGSRSVRRFYDT
MRRMGASARTMLERAAAQRWEVPAGECRAENHFIVHTPSGRRLSFGELAEAAAGQPVPEE
KDLRLKDSGQFKYIGKPVNTVDTPDMVVGRAQFGQDVAVDDMLIASIERAPVLGGKIIKL
DDSAARKVKGVVAVEQLDGGAEPPLFKPLSGVAVLAYNTWTAQKGRKLLDITWSETGHSQ
HDSDAYLKELKQAVQEPGKTIINHGDVDTALAGASRSHSATYTVPYLAHAAMEPLAATAQ
VSEGACEVWACVQDPQSVQQNVASALGLKPEQVKVNVTLLGGAFGRKSKPDFVVEAALLA
RKIQRPVKVVWSREDDMRHDYYHAASAAHFQAGFNGDGKVESWLQRTAFPSISGTFQAGV
DRPSNSELRLGLADMPFAIPNRRTETQRADYHTRIGWLRSVSNIQNAFGVCSFADELAYS
VGRRPDEFLLELIGSDRHINPSQGDYKYDNYGEDLKKFPVDTARLKQVLRRVAAKADLNM
RGDHEKNAGEGWGIAVHRSFLSYVGIASKVQVRDGQLKILEMHCAADVGLVVNPDRVRSQ
MEGAMIFGMSLALMGEIKMQNGAVVNSNFHDYPLLRMHQCPPLSVELIASEEPPAGVGEP
GVPPVAPSITNAIFAASGQRISELPINKHLKIG
>D4DXT2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera DSM 4582|TrEMBL
MELPVPDAASVTLKDPSQFRWIGKPVPRLDGYDKSTGKAIYTIDVQVEGMLHAAVQHAPR
LGLTVGSIRNEQQVTSMKGVHSVHRQEGAVAVVAQRWWTAKRAAESLQVDWNDPGAETSV
RYMPADFSSAAFNDRLANETGAGQDAETEGDIHQALTNAHQVVSATYRSQYLNHAQLEPP
STLARFNPDGSLDLWLPNQAPGMFQADVAKITGLGLEQIHIHSPLLGGFFGRHFLYPTAT
PYPQAIQLAKAVGKPVKLIWSREEEFLRDVLRPMAAVRFRGGLDEQGLPVALEAISATEG
PTEGVANKQGDALDPTALEGLSGKAYAIPNKRVAQLYVKNPVMLGYWRSVGNSMNDFLYE
TFLDELADKGGQDPFALRMHLLKGNSRLSNLLQAVEALSGGWKRGPFTAEDGSRRARGIA
MASPFGTEVAVIAEVSIEHGQVKVHDIWQAIDPGSIVNPALVEAQVNGAVALGLSQVLLE
EAVYKNGMPVGRNYDLYPILPAHRMARVHVRIIESGAKMGGIGEPPLPAVPPAVANAVSR
LTGQRIRSMPLSHYHFDSEKML
>D4E6K2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera DSM 4582|TrEMBL
MAMTVDSPREGAVTTLTEHPLMLSVNGQHVQVRVMADTSLLLVLRNDLALNGPKFGCGLG
ECGACTVLIDGLAARACVIPARGVTQRAITTLEGLGNRDCLHPVQRAFIEQQAAQCGYCL
NGMIMTTKALLDRNPSPSDAEIRRALSGNLCRCGTHIEILNAVKRAIELCAGEARDD
>A0A7W5ZVM6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium hassiacum|TrEMBL
MNNAAVLNRRSFMVASLTGGVVLTLDASLTLAAAAPGAAPDVLNAFVRINADNTVTIGAK
NPEIGQGVKVMLPMLIAEEMDLAWEQVRIEQTDADEKLYGPQVAGGSTATPRNWLPMRQV
GAGARAMLVAAAAKQWGVDAGALTTARGAVLHKASGKSLTYASLGKAAAAEAAPDLAKVA
LKDPAKFTIIGQSKMGVDVPKIVKGEPLFGIDTRVPGMVHAAVMKCPAHGGTVASFDDAA
VKAIPGVIAVIAVNSGFVPEGKTDTLLIVADSWWKASKAREKLVVKWDDAAVTGFSTAKY
EKDAAALFAQTPQASLFKAGDADAALAKAAKVIKADYDYPFLAHASLEPQNCTALFKDGK
LEIWVPSQNPGQGRAETAKLCGLSPDDLTIHLTRMGGGFGRRLMNDYMVIAGQAAKALPG
KPVKVLYDRTDDFRHDFYRPAGWHRFTAGLDAGGALVALKNHFVTFGKDGKPIRAAQMAI
TEYPAPVVPNVDLDVSYMATNLATGWLRAPSSNAMSFVFQSFMDEVAEAAGIDLPELMRR
TLGAPREIPGERVAFHTGRARAVIDAVCKNAGWKGRQKGRGFGFYFSHLGYFAEVVDIGV
SDGVVKIDKVWMAGDVGSQIINPINALHQAQGAAIEGLGQAMIGQKLVQEMGAITAENFG
DFALMRIDAVPREIAVEFLKTDFPPTGLGEPALPPVIPALANAIYATTGKRHRRLPLEMI
>A9GMW5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sorangium cellulosum (strain So ce56)|TrEMBL
MAKDMLLRAAAARWKVSPAACTAANGVVTHGKDKLTYGQLAEEAMKLAPPAKVKLKDAKD
WKLIGTLVRRIDTPEKITGKAQFGLDVHFPGLRTAVVLRPPAFGAKLVKFDAADALKVPG
VEKVVPTADGVAVVAAHFWAAKLGRDALRAEWAQPEGGGVDSAKLLAEFHAKARTPGTVA
ASVGKVEDALAAAKSRIEAEYDVPYLAHAPMEPLNCTVKIDGDRCEIWTGTQFQTGDQMA
AAKILGTTPDKVQIHTTFLGGGFGRRASPVADFVAEAVIVAKAAGVPVKVVWTREDDMRG
GFYRPAFVHRIQVGVDARGLPAAWDQVVVGQSIVAGTPLESFVTRNGVDLTSVEGIAESP
YVERTPALRVSLHSPRTPVTVLWWRSVGNTHTAFAVESMVDELAHAAGQDPLAYRLELLK
DKPRHANALKVAAEKAGWGTAPAPGRARGLAMHESFGSIIAEVAEVSIEEGRIRVHSVTC
SVDCGTAVNPLGIEAQIQGSVAFGLTAALYGKINISEGKVQESNFHDYPMLRMFDMPRIA
VHLIPSKAKMGGIGEPATAPIAPAVANAVFALTKQRLRSLPFRLA
>A0A840L4T4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paucibacter oligotrophus|TrEMBL
MKRRTLLLSGLGASAALLVGWGYLPPRSRLGHAGSLGQVEGEIGLNGWIKIAANGDVLLA
MHRSEMGQGVHTALAQLVAEELSLPLARLRLIPAGFESIYGNIAMFVGSLPLHPRQTEPG
HTSLGARLGQWTVAKLARELGINATGGSSSVADAWEPLRWAAATARQQLLGAASLRWKLP
LPELLLEDGLISHVSGPSAHFGELAKEAAATPPGEVRLKPKARWTQIGKPLARLDLAAKV
DGSAVFGIDVRPGKDLLFAAVRHCPMLGGGLGPVPVNALLQQPGVLRVVQLGTVAGSHAA
VAVLARNSWHAQRAAASLESAWQQRPAGALNTAQIESRLADSARVAAAQGHVFFSQGEAD
AALAQAPRKVEALYQAPYLAHATMEPMNCTACVKDGRVEVWVGTQVPGLARAVAARVAGV
AEAAVTLHQTYLGGGFGRRLEADHVGQAVRVAMDTGGVPVQLLWSREEDMTHDFYRPAGA
AFLQAGLDAAGKPLALRLGSAGDAISPRWMERVLPALAGPVEPPDKSASEGLFDQPYAIP
QQRIAHLATHSGVPVGFWRSVGHSHNAFFIESFVDELAHAAGADPLAYRLALLDGLPRHA
AVLRRAAQEAGWGQVLPKDRARGLALHESFGSIVAQVIELSSQQGKPRVHRVVCAIDCGV
VLNPGIVAQQMESAVIFGLTAALYGRIDIKDGVVQQRNFPDYPLLTLAQTPLIETHLMAS
DLPPTGVGEPGTPPVAPALANAWFALTGERLRRLPLATTV
>A0A2K4X799|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas carrageenovora IAM 12662|TrEMBL
MITLTINGNKHEFSGDPSTPVLWYLRDELNLTGPKFGCGMAQCGACTIHIDGVAQRSCVL
PVSAVVGRNITSIEGLSEQGDHPVQKAWVEHKVPQCGFCQCGQIMQAASLLAANPNPTDD
EIVSNMSGNICRCGTYPRIHKAIKSAAKTMAGVEYFDPNEQGEEV
>A0A1L3LVL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium americanum|TrEMBL
MLPKLMQSITLPAARVEASRRQFLIGALATGTGLAIGFRLLSASPAAASETPAAGAHAFS
PYVMIDGDGKVTVLSSQFEMGQGSYNGIATLVAEELDADWSTIDVKGAAGNLPAYGNIAF
GGAMQGTGGSTSMVTSWERYRKAGAAARAMLVAAAASDWGVDAAEITVNKGVLSHPSGKS
GGFGTFAAKAATLPVPADVKLKQPSDWKLIGNSELKRFDSARKANGTEQYTIDVKLPDML
TAVMIHPTLFGAKVKSFDASAARAIKGVVDVVETPRGIAVVGEHMWAAIKGREAVTVEWD
EAGAEKRGTQQLMSMYRDLVKKPPAAVARKDGDAEAEFAKAAKVIEASFEFPYLAHAAME
PLNAVARMNEDGTLEIWGGHQFTEVYQKLAGDVAGVAAEKVRLHVMKTGGSFGRRAVFDG
DVVVEAVHVAKAIGFRAPVKLQWTRENDMHAGRYRPAYVHSLKAGIDDSGKLVAWNDHIV
GQSIMAKTAFEGMVKNGIDPTSVEGANNLPYAIPNQTVGLTTTDVGVPVLWWRSVGSTHT
AFAAETFLDEVAEAAGRDPVEFRLSMLEPGSRHATVLKLAAEKAEWEKPLPQGRFRGVAI
AESFGSVVAEIAEVSTDGNGQIKVERVVAAVDCGLAVNPDQVRAQVEGGIGFGLSAILGE
EISLTDGAVDQGNFDLYTPLRIDAMPAVEVHIVASANPPSGIGEPGVPPIGPAVANAAYK
ALGKRLRVMPFSKSLDA
>A0A1V0PXC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MTDTQLSRRLFLKVTATAAGGALFAFNLSGARAQNATGSGTAMEDAPQVTAFLRIDPDGG
IVFLNPFIEMGQGTYTSIPQIVAEELDAPLEAFRVEQAPPGDAYKVFNFGAPLRFTGGSL
SVRGSYMTMRKVGAGARAMLLAAAADELGVPVAELRTSDGKVHHDASGRSVGYGALAARA
AAQTPPEDPPLKDPSAFKLIGQSPKRTDSLEKSTGRAGFGIDVQVDGMRFAAIRHAPSFG
GTVASFDPKSIDGMPGNPRAVDLGSAVAVVADSFWRAKKAVEALGVTWNDGAADISSERL
IDAALARLDETGIEAEAEGDAPAAIAGAVQELTADYVQPFLAHATMEPQNCTAWVRDNAC
EIWAPNQGADFVLGTAQQVTGLPAEAITVHTPYLGGGFGRRFVLDFATQALKLSMADGGP
VKLVWTREEDTQNDYYRPMAAVRLRAGLDAGGKPVGLHATTVTEGPAARLMPGLVQPNGL
DPTSVEGLVKQPYKVGARRTDMVNAGYDAVPVGFWRSVGGALNAFPYESFIDEMAHAAGQ
EPLDYRLALLEPGSNEYALLEKVRDMAGYRPGTYTAEGETRAMGVAQHEAFGSLVAQIAE
VSVRAGRAHVSRVWAAIDLGSVVNPEIVKAQVTGGAIYGLSAALHEEVVIENGQATRPNF
DTYPILTPQEAPEIEVAVVTSDRPMGGVGEPGTAPIAPAVANAIFKLTGTRIRRLPISRH
DLGAA
>A0A7Z0ISX4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides panzhihuensis|TrEMBL
MTQDETTYDGPRTSRRTLLGYLVAAPTLSVAVSLGLEQRAAAKVITPPGVADIMDLSDAQ
LLAVAPTANLISLDLREDGTVHFALPRMEVGQGITTSTAMIIADELDIGLDKIEITLADA
RPELLMNQLTGGSNTTMTTYLPIRTAAAIARRRLLDAASTMLGGDVPLAALKTVDGKVLA
PNGVEISYGELAASASVDETVEVEAQLKEPAEFTVIGTPRNRIDARAAVTGRKQFTMDMD
VPGALPTMLCRPPTLNGKVDSVRNRAAVLDMPGVTHVAEIPTGVAVRAETFGQCIDAIRA
LDVTWGPGPVDGLSDADILERVRRAEIPLAVPKVPLLAKTVETNSTFWFRSNSALETNCA
IADVRPGRATVWGGFKAPIVAQERIAEILGLPPTSVTIHVVTGGGSFGRKVFPDAAVEAA
QASKAMGVPVKLMWHRADDSRQGRVHPMATTRIRATVLAGEVLTWELRHTGVKNDFTHGF
GDVLTATAPRLPVADLGFSETVFALTQAYHYDFGVSTQLLNEIDLGFTTGAMRNIYSPDV
ATARELTVDKIAAAVGKDPYRFRQAFVREQRAKTVLDAVAQQGHWGRAMPAGTAQGIAIN
NEYHSFSACLVEIDCRPETVNRKVREGVTGPRVTKVVIGVDAGLVVNPRGLDAQMMSGAM
DGIAQTLTSSLHLRDGYFLEASWDNYAYTREWNTPPTVEVIIVPNDSEDPGGAGELAVAA
SMAATANAYARATGKTPTEFPINHHDPSHFEVKPTIPPVPQSPTDGLTYLQE
>A0A088U368|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MIDIVVNDTRHSLENVPEDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHLEGQAVRACL
IPAVAAHGRHVTTIEGLSPDGRRPLQLAWVAEDVPQCGYCQPGQLMQAAALLKGGQPVDD
AAIVQAMSGNICRCGTYARIHRAIKRAASGEPAKEA
>A0A448TT25|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinobacillus delphinicola|TrEMBL
MITVQMTINNKKVGPFEVDESLKMIDFLHEYLNLTGTKFGCGIGVCHACVIIVDEPDGTS
HTERTCINGVGAFNGKTLRTIEGHAKRNPMGQIVSLSPVQQTFVDHFSFQCGWCTSGFVN
ESTVLVEKLKKNPIAKEEVEQVIENTLKTHICRCTGYRKYYVGLRDLILSQGGLIK
>A0A1X6Y9V0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria meonggei|TrEMBL
MTINTTRRGFLKSAAAAGAVLLVGARPDGALAAASSETAQFNPFVKIDADGTVTAIVKHF
EKGQGPATGLPTLIAEEIGLRMDQIEYEFAPSDPQVYNNLLFGPFQGTGGSTAMANSWMQ
YRQAGAAAREMLINAAAQSWGVAASDVTIEEGIVNAGDKSAPIADFVAAASQLEAPVEPR
LKDPADFRLIGNEAVRRKDSAIKGNGQAMYAMDVHLPNQMIAMIKRPESRGGIATGFDDS
ASKEVKGYINATVLPNQAGVAVYAENTWAAIQARDALEVEWDMSGAETRDSDQIKAEIMD
ALEAEATYNVNKADVAAVSAAIEGADQVVEKTFYFPLLAHAPMEPLNCTIEQTAEGNIVL
HDGSQMPTGPHMAYQQIFQLPPEKIQINTMLAGGSFGRRATPDADYQVEAALAFVVTDRS
RPVKLVWTREDDIRSGYYRPAFGHKARVGLNAEGEIVGWQHQVAGQSIMKGTPFEAVVVH
GGVDHSSVEGIADSPYEIPGMALGLTDTPKATSVLWWRSVGHTHTAYTMETMMDLAAQAA
GRDPVEFRLAHLSDASDPDQQRKAAVLKLATEKAGWGTAPEGRSQGIAVHKSFGSYVAEV
VEISGDPESGIKIEKVTCAVDCGIAVNPDVVKAQMEGGIGYGIGHVMRDQITLTSGAVDQ
YNFPDYEPLRIGDIAAIDVHIVPSAEAPTGVGEPGTPPSAPALANAITAMSGLHMAELPM
AENGVSFV
>A0A6S6Z9P9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter kerstersii|TrEMBL
MPNSRITRRMFIAGSGVAAVGVAFGAWKWRDAEQAPEPASALAPEAASVFSPVAWVSIAS
DNTVTIYSPAAEMGQGTMTSLPTVLAEEMEVDWSTVRVEQSPVNPGTFGNPGFGGAMVTG
SSRTVRGYYLPLRLAGLQARRVMEQAAADIWGVPPTEVRAEKSTLIHESSNRRMTYGELA
KVAKAPTTLPVVDKSMLKPMSAFTLIGKDVPRIDVPSKSDGSAIFGIDVRLPGMGWAAVK
YAEVQGEKPLSVDSTEAEAVSGVKKVITLPYGVAVVADSFVTAKKARDLLVVTWSHDAPG
RSYDSDEVMTEYVARAKQMTEAGTTWNKRGDAQAAINGAARTFTATYRSTHMAQMTLEPM
NCTAWVQGDKIEIWAPSQIPSGVLGVAIQSGFKPENVKVNITLLGGGYGRRAEVDFAIDA
VLIAKQMPDTPIQVIWTREDDFQRSKPRPMTAQHLSAGLDADGRIVGWRHRVTSEGATIR
LAPALYDATGGKDPTVMKGSENVYDIPNQLAEHLPEKRGIDVGYWRGVGPSYTKFAAETL
LDEIAAHLKKDPLQYRLDMLRASPRAQAVLRRTAEMANYPASRGAGHALGLAFSDAYESF
IAMVVDVSIAEGRIVVHEVWAAVDCGHAISPANIKTQIEGSALYGLSAALGEKLDYKGGQ
AQQQNLHSYPILRANGTPLVHVEVIPTDNPPEGIGEVGLPPLAPAVANALAQLTGRRLYT
LPFPATV
>A0A7W6FPV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium jiangsuense|TrEMBL
MTKFTVNDRPVQYRMEPDTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAVRSCRI
SLAQCEGRFVTTIEALSTDRSNPVQQAWVAENLPQCGYCQSGMIMAASVLLRKNRAPSDE
QIDAAITNICRCGTYPRIRAAIRRAARIMEGQERIAAAPPPGITPEDAARAVPALRGQ
>A0A7W6T3Z4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. SBR1B|TrEMBL
MNKHISPRLNRRAFVIGTAAVGAGLAIGLDLPFGGPAVVRAADGSPEIGAWVVVRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELECDWTKVTTEYPTPGQSVARKRVWGDFSTGGSRGI
RSSQDYVRKGGATARVMLIQAAADAWKVPASECAAANSVITHTPSGRTTTYGKVAEAAAK
LTPPADVKLKDPKDWKLIGKGVKRLDTVDKTNGAMIYGADIKLPGMLNAAIKDCPVFGGK
LKSFDEAKIASMKGVKKVVKVGDTAVAVVADTWWHAKTALEALPIVWDEGDNAKVSSESI
AKWLAEGLNNDQPAYVGNKNGDAKAAIASAAKKVEAVYSYPYQNHATMEPMNATALYTAD
KCEVWCGTQNGEAAFAAVLEASGLPADKCDVHKVMLGGGFGRRGQTDYVRQAVMIAKEMR
GTPVKLLWSREEDMAHGRYHPITQCKMTGAFDANNNLVALHYRLSGQSILFSLRPEALQN
GMDPAAFQGVAQSGEAAFGYSVPNLLVEHAMRNPHVPPGFWRGVNVNHNAIYMECFMDEL
AQAAGQDPLEFRRKLMGNHPKHLAVLNAVAEKIGWTTPAPQGVYRGIAQVMGYGSYVAGA
AEISVTDGSKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGKIEQ
TNFDTYNSMRINEMPKVESVMVPSGGFWGGVGEPTIGVAAPAVLNAYFAATGKRIRSVPL
RDQNITFA
>A0A2R5F491|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novimethylophilus kurashikiensis|TrEMBL
MVTLNVNGKDHALDIPDDMPILWAVRDVIGLTGTKFGCGKALCGACTVHLDGNPIRSCVT
PVSAAAGKKITTIEAIGDTPEGRKVQQAWLALEVVQCGYCQSGQVMAASALLKSTPNPTD
QDIDQAMAGNICRCGTYPRIRAAIKQAANVKAA
>A0A0A1FF96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas arenae|TrEMBL
MSAAFDFDKDSANTEASPTVASVSRRTWLKGVGAFTGLALTVGVNGLVRAADAAAPAKKY
GGAGMPGGTVNDPLVFVTIGADGIVTIIAHRSEMGQGIRTSLPLVVADELDADWGRVRVV
QANADESRYGNQNTDGSRSMRHFFTPMRQVGATARLMLVSAAAARWSVPAAEITTKNHEV
WHAKSGRKLGYGELAVDASKLQVPVQAPLKDPAQFRYIGKDAFNSVDFRDIVTGNTHYGI
DTRLDGMLYAVVARPPVYGGKVTSFDAAEALKIPGVVRVIELKGSPPPAKFNPLGGVAVI
ARNTWAAIKGREALKITWDNGPHAGYDSTAFKTTLQEAARKPAKVVRNNGDTMAALAQAG
KKIEAEYYIPHLAHATMEPPAATARTANGKCEVWACVQDPQATRDTVAGKLGWKTDDVKI
NVTLLGGGFGRKSKPDFAAEAALLSQAMDGVPVKVTWTREDDLRHDYFHTVSLEHLESTL
DAKGKPVAWLHRSAAPTIASTFVAGAKGEQPGELGMGAINIPFMIPNIRIEAPEVEAHTR
IGWFRSVYNIPHAFAVQSFVAELAAEAKRDHREFLLELIGPARQINPQDMSDTTNYGESP
VLYPLDTGRMRQVLELATKEAGWGRKLPKGHGLGLAVAYSFMSYVAAVIEVVVGADGEIS
IPRVDMAIDCGPQITPDRIRSQVEGACIMGLSLAMTGEITFKNGSAEQGNFHEYEVLRAF
SAPRDLRVHMVPHKYDMPLGGVGEPGTPPIAPALCNAIFAATGKRIRNLPIRDQLKKS
>A0A401MR10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. NL15-2K|TrEMBL
MPRHSRRRFLTYLVAAPTLAVATKIGLDALAPGDAEGAIPTPPAPADLVDLGDLLILAGK
PTASMLVLSVDEEGVAHFRLPREEVGQGLTTAVAMLVAEELDTPLDRVRVQLDDARPELL
FNQLTGSSNSIRSLYDPVRHTAAAARARMVGAAARQWDLNASDLTVRQGVVVAPDGRTAS
YGSLSAAAATLDLGALTVTPKKESDHSLVGTPTSRIDARALVTGKHQYTLDLEVPGAEPC
MVRRPPTVNGTVKSVNNEAAVRAMPGVLDVVTIDTGVAVVAKTFGQALDAKNALDVTWGP
GTVDELSDDGIRAKLKAATPSLDVLGALVKKVEADFDFAFASHAPMETNSAVADVRADRA
EIWSGLKSPIIAQAAVAKVVGLPVSKVKMHVVQSGGSFGRRLFYDAALEAAVVSKKTGRP
VRLMWSRIDDMRHGRMRPATHHRVRATYAAGQVLTFQHQVAAVETDFRHGLGDAITAAAA
GLPSGLGNATFAQTLFLTTVKSPYNFGLTTQTLTEVPLKMHTGSWRSVYSGNTRGAEEIV
VDELAAKLGKDPVAFRRAFLKTARQRAVLDKVAEEGEWGRSLPDGWAQGVGFHEEYKSCT
ACLVEIDATDPKKPRVTKAVVAADVGRVINPRGLEAQLLGGLTDAISTTLRAGLHLDKGL
PLEGSYSQFHYARQKDSPKDVKIFVIEGGDEPGGAGELGVPAAVGAVANAYARATGTKPR
SFPVTFDVDFTPFPR
>A0A7W8NDE5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. ANJX3|TrEMBL
MKIKNSPSEASEAIDLGRRRAIQSGGFAVAFLWLGSTGAASAMVSARRQPGDAAATLADG
NPPFAPNAFVRIDTDGSIRLVMPSVEMGQGIYTGFSMLLAEELGVGLDQIKVEHSPASEE
LYGMPALGGQITGGSTSTRSGWQVLREAGAVARAQLVTAAAAQWKVDPSTCTVDRAVVHH
VPNGRSLGFGALATPAGKLPMPDKVPPLKDPKDFVLIGKPLRRVDSPDKITGATQFGLDV
KVPGMKIAAVKTSPTFAGKLVSVDDKAARAMPGVVDVIRIGDAVAVVGDHYWAAKQGLEA
LDIQWDRGVNANLTTQQLRDALADSALNGSSIVAKEVGTRPATDTTIDAVYQLPMLAHAT
MEPLNATVSVTADKCEIWTGTQVPTRCVTAAAKITGLSEDKVLLHNQYLGGGFGRRLETD
QVEQAVAFAKQVGYPLKVVWSREEDIRHDRVRPMYHDRFSAVVNADGLPVWFGARTSGGT
VLGRWAPMAMGKNGLDSDAVESLAEMPYEIPGMKVEWIRHDMPPGLIVGWWRGVGPTHNL
FTVESFMDELAHRAGKDPVAFRRAMLQKNPRTLALLNLAAEKSGWGTPLPARVGRGIALG
EPFGSRVCAVVEAEVTPQGEVRLRRAVVALDCGIGINASSIEAQVQGGLLFGLSAAMWSS
ITIKNGAVEQGNFNDYRNMRINEAPSVEVHRIENFESPGGLGEVGTAIAAPALANAIFAA
TGVRLYQLPVDRSLLVQDADALKSVVSADNANAEGVA
>A0A128FIF7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia marina|TrEMBL
MPLWRLEPYAVKVARTVLRETALGNKCRPPDKPLPKGKGRGVAVHESFRTFVAQVVEVTV
ENGQITVDKVVCAVDCGVAINPDIIKTQMQGGIGFGLSPALVSEITLQDGATVQSNFHDY
LVLREMQMPEVEVHIVPSAEAPTGVGEPGTPPIAPAVANAVFAATGQRLHDLPMKLS
>A0A564G365|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium dankookense|TrEMBL
MNDLSPLRAGGHDREPVRNLSRRGFLGAASGALLLGVGLRLEPAVAQTRAEGPAAVAPKP
GTRVAAFLEIRPDNSVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFAVECAPPGPDYA
VVNGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAAKLAVPQASLTTEDGRVIHAGSG
RALGYGELAAAALALQPRDDVPLKAAKDFRWIGKPVARLDMRDKSTGRAVYSIDIRIDGM
LHAAVRHAPHLGTEPEAIANEAEVRALPGVQSIHRLPGAVAVVADTWWRARKGADALAVT
WTKPAPEGVDTVSAGFSSAAMLAALKDSTAPGIPAEQEGDPDSAFAKATKVVEAEYDAPY
LAHAQLEPPSAVARFAADGSLDLWLPNQMPELFQQVAAKVAGLQPDDVRIHSPMLGGFFG
RHFYYGPASPFPQAILLAKATGRPVRVLWSREEEFGMDAVRPLSFARFKAALGPDGLPVA
LQTTAVGEGPIGRWFGALFKSPVDSSVVEGLDKKPYAIPNRRLDYVKVPHPVTIAFWRSV
GHSMNDYFYESFLDEVAQAGGKDPFDLRMALLTDSARHRTLLQTVADLAGGWRRGPFTAE
DGTRRARGVSMASPFGSETATIAEVSLKDGEARVHDLWIAIDPGSVVNPGIVKRQVEGAA
ALGLSSTLLEQVVYEGGQRQARNFDAYPILDRERMPRVHVAIVESGAPMGGIGEPGLPGV
PPAVVNAVAALTGSRPRSLPLSKARLSGA
>A0A0M4MX96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Altererythrobacter epoxidivorans|TrEMBL
MTGITRRRLLVGAALGGGAIVAWTLMPRSYPTPLEVGRNEYAFDAWIKIGSDGVITVAVP
QLEMGQGVTTLLPQIVAMELGADWRQVAVEPAPPSGTYANIPLAAKWSAMWMPFWDGLAD
EPDDLVAERFARGSRFTGTADGTTLAAYEMPCREAAAAARAMLAMAAADRWGVSWEECQA
ISGFIFHGEKRLSFAELAEEASGFEPPDPPPLLPEPPAEKSLPGEVDAPTAYPRLDLPSK
VDGTYQFAGDVRLPDMVYAGIRHGPIDKAVLTDFNPFNARGIRGIVGAVKGKRWLAVAAR
SWWAAERALETMQPRFTVESLVDSDDITERLDRGLREGEAYNIAMRGDGYSSGGKAGIAR
IYEIEAGVHAPLETASATARIIDGRLELWVASQAPELTRKAVAKAVGFDIRDVVLYPMSA
GGSFDRRLEHDHAIEAALIAQDLDRPVQLIWSRWQELLMTRPRQPAHLLLTARLSQDGQG
NIDAMKTRIATPPANVEFGHRLFDNTTTWAAIRDSENIPDPMSCEGAMPAYDIGHVQVDH
VPVEIGLPCSRMRGNSHAYTAFAIESFIDEIAHKHAREPLSFRIGMLGADVRLAQCLQRA
ARLAEWGGGVDQSGQGIACHRIGDVATGGRIACIASARAGEGGVRVTKLTAAVDIGRIVN
LDLARQQIEGGLVFGLAMAMGASTRYRGGLPVAQQMSALNLPKIDDCPEIEVEFIDSSAE
PFDPGELGAVVAAPAIANALFSSTGLRLRRLPLISNDGL
>A0A1Y2MGG5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia autotrophica|TrEMBL
MPAHRAPAPERPASDGARSNVSRRRFLGFLVAAPTLVVAAELGRQTVFGGSVPQANAAAI
PSPPLPAEVYDLLDAVRDAARPTANLIRIAVNRDGTVSFALPRSDNGQGIITSTQMIIAE
EMNLDPDQVVVTLADARPELVFNQLTGGSTTTFSTYTPIRVAAALAQGRLLDAAAAQLGQ
EKSVLTSRTGLILGQNGEELPFGELTEAAASPVDDIVDVVLKPREEFTVIGTPRTKSDAR
AMVTGKKKFLTDLQVPDALPTVICRGPNLNSAPTGVNNIDEVRNMPGVTDVAQVRTGVAV
RAVTFGQAVDAVNALDVSWDGGTVAGEDDESILATVRRGELPLAVPQVPGETVEGEFVFY
FRSNSALETNCAIADVRSGSAELWGPSKSPIAAQAEIAQELGLPQNAVTIHVTEGGGSFG
RRLFFDALQEAAEVSKVMGKPVKLMWTRADDSRQGRVHPLATTRVRAQVSGESVSSFEIR
HTSVSTEVNPGFSEGITAAVAKLPLGNYSVSQAIYLTTQTNPYNVGVATSLLNEVDMRFN
TCSMRNIYSPDTATARELMIDQVAARMGKDPYEFRSGFVKLERFKKVVDRAAEEANWGKS
MPAGTAQGIAIHQEYKGIACAVVELDCRPETVNREIRSARTGPRVTKVTYVVDIGLVINP
RGLEAQMMGGINDGIAMTLTSGMHLEDGHFVEASWDNYFYTRQWNTPPEMNIVIIDDSEA
PEPGGAGEFGVAATCGAVACAYARATGTVPEYFPIMHKDPLPFEPYPTVPPVPPAPTNGL
ELAR
>A0A0M6Y4X5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium aggregatum|TrEMBL
MKIDENSGFTRADINTARPLNVSRRGFLAGSISALVLTVSLPAGTGRAIAQAGQTTPGTR
IDAFLEILADSTVKFRSAFVEGGQGIYTAMAQIVGEELDVEPGNFQVETAPPGPDYLLIG
GQIRFTGGSMSVRMSYDAMRKLGATARQMLLQAASERLGVPIETLTTEPGKVVHPASGQS
IPYGDLATTAADLPVPETVELRSKDEFRWIGKPHDRLDVLDKSTGQAQYAIDLSVDGMLY
GAVQHAPRLGQQPGAFANEADVAAMPGVHSLHKLPSAVAVLADSWWRARMAVEKLEVEWT
EAPAGTARAMPDTFSSEAHKEMLKATAGQGIAFEAEGDADAALASSAKVIEAAYDVPYLA
HGQLEPPSALVRWNDDGTLEMWVPNQAPEMFQADAAKVAGISADKVIVHSPMLGGFFGRH
FLYQTANPYPQAIMLSKAAGRPVKLLWSREEEFLRDALRPIGTVRFRAAIGPDGHPLAFD
AVAVGEGPTGRWYGRQPDKVDSSSVEGIAGKPYAIANKRVGQIHVDDPAIIGFWRSVGHS
MNDFFYESFFDEMADAGEQDPFELRLKLLDHSPRHKTLLQTVGDLSGGWKRGPFEAEDGT
RRARGVAMASPFGSEVATIAEVSLDGGEVVVHDVWVAIDPGSIVNPAIIEAQVNSAVALG
LSSALLEEVVYTDGMPEARNYDMYPILPPERMPRVHVRIVESGAPMGGVGEPGLPGVPPA
VANAVAVLTGERIRSLPLSRFDFSGANG
>A0A7Z0BUF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium marinum|TrEMBL
MSRLTVNERPVAFDMDPQTPLLWALRDAANLTGTKYGCGVGDCGACMVLVDGEALRSCLI
TIGEAEGRFVTTIEGLSRDRSHPVQQALVAEQAIQCGFCTPGIAIAAAALLARNADPGEE
EIGQAIPNLCRCGVYPRLVRAIQRAGRVMRRAETISAAPAPGISPDDAAEAVPALRTSE
>A0A482ZMZ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MLGVRCCDLRIDLSRLHLIAVKLAVTGSCDLRIDLSRLHLTALRDDGITGCDLRIDLSRL
H
>A0A100JJJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces scabiei|TrEMBL
MPSYSFVLNGKPVTVDAPASMPLLWVLRDMLNVTGPKYGCGVGVCRACTSHLDGGEIQPC
VVPVADCADREVTTIEGLADGDELHPVQQAWLDCDVAQCGFCQPGQIMAAVALLKKTPHP
TDADIDRIENVCRCGTYSRIREAIKKAASG
>A0A7Y9HJ34|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MTDRRLFLKAMAAAGGGLALHIAIPSARARDAATAATTAFEPNALVRITADGKVHLTMPY
VEMGQGTYTSVPMLIAEELEVDLKDVQLEHAGADDKRYVNPALGFQVTGGSTTMRAAWMP
MRQAGAAARMLLVQAAAQQWQVDPASCRAEHGAVIHAASGRKLPYGALADAAARLPLPDP
KTIVLKDPKDFRLIGKVTRRLDTHGKLDGSAQYGIDVQLPGMKVAALAITPVFGGRLASL
NEAAALKVPGVRQVVRLEDGAAVVADNYAAAQRGVQQLDLRWDDGPNAKLGTADIVADMV
RSADAGSAKVRSEGDPEQAFRNAARVIEATYEQPFLAHAAMEPMNCTVHVTPDSCEIWTG
TQVMTLARGVAAKVTGLPVEKVTVHNFLLGGGFGRRLEIDGVERAVRVAREVRHPVKVIW
SREDDIQHDMFRPYFYDRIRAGLDAGGAPVAWSHHVTGSSVLGRFLPAAFNNGWDSETLD
GAETPPYAFKSIKVDYTRHEPPHIPTAFWRGVGPTHNVFVVESFIDELAAAAKADPLQYR
LALLKQNPRAEQVLRLAAQKAGWKGPRAGKTGRGLSVQYAFGTYMAMVVDAHIEDGEVRV
SRVVCALDCGVAVNPDTIRAQVEGAAIFGISGALYGNVTFKDGRVEQSNFHDYRVLRMNE
TPVIETHIVASNEAPGGMGEPGTSAVMPALANAVYAATGQRVRKLPIAAALAATPT
>A0A654CX45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia sp. 8Y|TrEMBL
MSRGLLEAGRHAAPAGFSRRSFLKLGLTAGVTASGGFLIGFSVPAVSQDQGRGKSVIGGE
GVEGPQTGVFAPNAFVQIDKAGKVVLIIPKVEMGQGVYTSLPMLIAEELEVPIDSVTIDH
APPDEKLFMDPLLGGQLTGGSTSVRYAWEPMRKAGAAARMMLVAAAAQQWQCDASTCHAQ
GGKVVHASGDRSASYGELVQAAASMPVPQDKDIKLKDPKDFKIIGTQVRRLDSPEKVDGT
AVFGLDVRLPDMVYAAIVNCPVFGGKLASVDDTHARKIPGVRQVIKFDNGVAVIGDHTWA
AKRGAAALAIHWYEGADANVSMKQIVDELATASQKEGAVARKDGDVGKAFGNAKTRIDAV
YQQPFLAHATMEPVNCTVHVRPDGCDIWLGSQVPTRIVDAGVAITGLPREKIVLHNHLLG
GGFGRRLEVDMATQALKIGKQIGVPVKVTWSREEDIQHDMYRPYYYDKLSAGLDANGKPV
AWTHRIVGSSIMARFAPPAYKNGIDPDAIEVAADLPYDLPNQVIEYVRHEPRHVPTAFWR
GVGPTRGTFVVESFIDELAAQAKVDPVQYRRDLLGKTPRARNVLDVATQAAGWGKQSMPQ
GQGRGVSVMHAFGSFFSMVADVTVNKDGEVRVNRIVCAVDCGMVVNPNTVEAQVQGGIIF
GITAALYSEITIKDGRVQQSNFTDYRMLRIDETPPIEVHIVKSTEAPGGIGEPGTAALAP
AITNAIYAATGKRLRQLPVGNQLRSA
>A0A7W8S1T0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MSNMSPARAPLSRRQFLKMFSAAGGGLMLGIAFPTAVDAAPIVPDSYEANVFAPDAFIRI
APSGQVTLIMPRVEMGQGSYTSIPMLIAEELEIALDNIALEHAPANDVLYRDPVIGSQIT
GASASTRSEWLPMRQAGAACRVLLVNAAAMNWKVDPASCRAENGTVRHVPTGRTLSYGPL
SVLAAKLPLPHNVALKDPHTFKLVGTPVKRLDARAKVDGSAGFGIDVRVPGMRIATVAAS
PVVGGRLKSVDARLALQIAGVKQVVQIDDAVAVVADHMWAARQGLAALVIEWDEGVNARF
SNASLIAKMEEASANDGVVAQQVGDVAHALNGKGNRIEARYELPFLAHATMEPMNCTVHV
TPDGCDVWCGTQVPARAQATAAEVTGLSLEKVRVHNQYLGGGFGRRLEVDYVTQSVRFAK
QVQGPVKFVWSREEDIQHGLPRTYYLNRIEALLDSSGQPQAWAHKVTGAAVMARYLPSTF
KNGVDPDAVNGAINLLYDIPNVKVNYVRYETPMPIGKWRGVGPTHNVFVVESFMDELAHA
AGKDPFEYRRALLAHQPRAKRVLETVASEAGWTTPLPAAKPGVRVGRGISVQFAFASYLA
EVAEVEVNEQGEVRIRRIVCAVDCGHTVNPDTIRAQIEGGIVFASSAVLWGEITFRNGRI
EQGNFNDYRVMRINEAPAIETHIIDSAEAPGGIGEAGTSALFPAVANAVAAATGTRIRKL
PINPAMLKV
>A0A0P7YG32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Erythrobacteraceae bacterium HL-111|TrEMBL
MSSMTVNDRPVRFDLDPQMPLVHALRDAMNLTGTKACGGDCVGACMVLVDGVALRSCRIT
LAEAEGRFITTIEGLSGDRAHPVQQAMVAEQAIQCGYCTPGIVIAAAALIQRNPAPSKEE
IEEAIPNICRCGVYPRLVRAVQRAGRVQQRRETISAAPPPGISADDAAEAVPALRPAVGP
R
>A0A857JPF7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola mesophila|TrEMBL
MQLNVNGTQHDVDVDEDMPLLWVLRDELNITGPKFGCGIAMCGACTVHINGMPARSCSMP
VGQVSGLITTIEGLGTPDAMHEVQAAWVEHQVAQCGYCQPGQIMSAAALLQMNPNPDDEA
IDRAMSANLCRCGTYPRIRAAIKAAAQTIREKSA
>A0A3S4Q5Q7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter spanius|TrEMBL
MGSTVNSSSTPPPIRLSVNGRECDVPAAPDTALLHVLRNDLALNGPKYGCGLGECGACTV
LIDGVAARSCVIPVRAAQGRAVVTLEGLGTREQPGTTQQAFIDCQAAQCGYCLNGMIMTV
EALLRRNPDPSEDALRSELHHNLCRCGTHVEIMQAALRAVRLRAEAADVRGSQAAGGGGA
AGVAGVAGVPDVPGVAGVADGGSTR
>G0AU69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica BA175|TrEMBL
MAEVLSTKAVVKEANTAASTQTLSAQTLTINGKSFTLDADPKMPILWALRDILGLTGTKY
GCGAGLCGACTVHLDGQPVRACLTSLGQAQGKRLTTIEGLDNQKLKNAWAEHNVPQCGYC
QAGQLMSAAALVAQHPKPSEEQINSAMSGNLCRCGTYPRIKAALQNYAKQEG
>A0A833J8Q6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MISLTVNGRQHAVDADPDTPLLFVLRDTIGLTGTKYGCGIGQCGACTVLLDGQATRSCQV
PLESVGTQGITTIEAIETDPVGAKVVAAWVGIEVPQCGYCQSGQVMAATGLLKETPKPSE
DDIAAAMTNLCRCGTYNAIAAAVRQAAV
>G7QBG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Desulfovibrio carbinoliphilus subsp. oakridgensis|TrEMBL
MIAVTINGHRHDLDVPDDMPMLWVLRDVLGITGPKFGCGIGQCWGCTVLVDGKPRPSCGL
PAKAAAGTTIVTIEGIPEDHPVKAAWREAQVPQCGYCQPGQILRAVALLDETPRPSEADI
AKAMRRHICRCGTYQRIKAAILLAASIKAGERPAPPPWPTPAEADTPAETFALNPFVSVA
TDGTVTVLSKHLETGQGVLTGLATLVAEELGADWGQIRAAHAPADERVYNNLVFGPMQGT
GGSTAIANSYTQYRQAGAGARAMLLAAAADHLDAPAGELRVEKGVIRHEASGRQATFGEL
AARAATVAPPADPPLTPASAFTLIGTSPPRLDIAEKVSGAARFALDVRLPGMKTAVVARP
PRFGGKVASFDKAPALAVSGVTDVVEIPSGVAVVAENTWAALEGRRALTVQWDDAGAETR
GTADLRREYLALLDTPGGAVRRDGDVEAALSGAATRLSAVYEAPFLAHAPLEPLNCVARF
TENGLEIYAGDQFQTVDQENAAQAAGLADKRTVTIHTLYSGGSFGRRANPGSDYIVEAVH
VAKALGKKVPIHLVWDRGDDLRGGRYRPMMLHKVEAGLDTDGRLAAWQHRIAGQSINVNT
PFEGALIKDGVDVTSVEGVSDMAYAIPNLAVELHTTTAKVPVLWWRSVGHSHTAFAVESF
VDEAAHAAGRDPLDYRRELLAGDPRRLAVLDAAAKAAGWGAPLPDGHGRGLAVHRSFDTY
VAHVAEVAAQKDGTFAVTRVTCAVDCGVVVNPDIVAAQMEGGIALGLSAVLEEALVLENG
GAVPENFNRYPILRFDRMPTVDVVILPSDAPPTGVGEPGVPPLAPAVANALFAATGRRLR
RLPLLGEQPSDARSGG
>A0A411Z9I8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Altererythrobacter insulae|TrEMBL
MAITRRGLLAGAAAGGGLLVAWTLWPRSFPNPLETREGEQVFDAWLKIASDGVITVAVPQ
LEMGQGVTTLIPQLVAAELGADWRQIAVEPAPVSGRYANIPLAAKWAPMWANFPALADDP
DGILAARFAEDERLNITGDGTALEAFEQPCREAAASARAMLAQAAAARWNVAWEECRASA
GFIVYEDRSLSFGELAMEAAEFDPPDPPPLTPEPYSEDTLPGEAEGSTAFPRLDLPSKVD
GSFLFAGDVRLPGMVYAAIRHGPLDKAELTEFNPFNARNISGIVGAVEGKRWLSVVATTW
WAAEKALDTMGARFSVEHVVNSDMIEEQLDSALTAGEAERIAERGDPDAQLETPTIELRY
DIEPGLHVTNETSTATARFADGMLELWIASQAPERARIAAARALDIDVEDVVLYPMPAGG
SFDRRYEHDHAIEVALIARKIGRPVQLVWSRWQEILASRPRSPAAITIKAKVTAGADGNI
TAMATRIAMPPANLEFGKRLFENVTTWSAIRDTEGEADALACEGAMPPYAIPDVSVDHAP
VEIGLPVSRQRGNANTYTAFAIESFIDEIAAENGREPLSFRMAMLGSDTRLAACLQGAAS
MAEWGGGGDQSGQGIACHRIGDAETGGRIACVATARAGEGGVRVDRLVAAVDIGRIVNLD
IARQQIEGGLVFGLATAMGASTRYSGGLPQSQQLGALNLPYLADCPDIVVDFIASDAAAF
DPGELGAVVAAPAIANALYSATGLRMRRLPLLSGGL
>A0A840YLP0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas xinjiangensis|TrEMBL
MTRFTVNNQPVEYKMDPRTPLLWALRDASNLTGTKYGCGTGDCGACSVDVDGTLRLACQE
TIGGLEGTFVTTVEGLPRDRSHPVQQALIAANVPQCGYCIPGIVMAASVLLRTNRNPSDD
DIKVAIPNVCRCGIYPRLISAITDAARIARGDATLDGADEMDNAP
>A0A7U4DWJ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia sp. AS13|TrEMBL
MAISEVPTSREGAVKMLTEHPLLLSVNGKSIHTQVMTDTPLLLVLRNDLALNGPKYGCGL
GECGACTVLVDGIAARSCVIPALGVADRAITTLEGLGDRDHLHPVQRAFIEEQAAQCGYC
LNGMIMTTKALLDRNPSPSDGEIRQALSGNLCRCGTHIEILRAVQRAIILCRSEENPHV
>A0A089NWD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium oryzae CBMB20|TrEMBL
MIHDAKMSAQLAAGTKPALDNVSRRGILGGAGALVLALSLRPARADETQTAEQKAQKFGA
DGMPHGWRDDPKIFVAIAPDGTVTVTNHRSDMGQGIRTSVAFTVADELEADWSKVKVVQA
WGDETRFGNQDTDGSRSTRHFFQHFRHAGAAARLMLIQAAAKQWGVPASEVTAVNHTLTH
AKSGRTLGYGAVAQAAAELPVPTDVKLKDPKDFRYIGTGKVGLIDNFDITTGKAVYGLDT
KLDGMLYAVVARPAVYGGTVKSFDDSEAKKVPGVVKIFKIDGGTIPSEFMPLGGVAVVAK
NTWAALKARDALKITWDDGPNAGYDTDAFRKELEAAARKPGKVVRTQGDVDGALAKAKTR
VEAEYFVPHLAQAPMEPPAAVARVKDGLCEAWACTQGPQAANDRLMKALKLPDDKVKVNV
TLLGGGFGRKSKPDYVVEAALCSQAVGGAPVKLAWTREDDLHHGFYHTISVEHLEAGLDE
KGMPVAWLHRSVAPTIGSIFAPDPKHELPFELGMGLVNTPLNIPNMRLENPEAAAHVRIG
WFRSVSNIPHAFAIQSFVSELAHAAGREPKEYLLDLIGPDRKISPTEIGDVWNYGEDPKR
YPIETGRLRGVIEAAAKGAGWGRQMPKGTGLGIAGHYSFVTYTAVAAEVEVDDKGQVKVK
AIDIAVDCGPQVNPERIRSQMEGAVVMGMGLALTSEITFKQGRAVQNNFDGYEVLRIDAA
PKVVRVHLVPTGNWDGPLGGVGEPGVPPVAPAIANAIFAATGRRVRQLPIRDQLSA
>A0A679IL74|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium bullatum|TrEMBL
MLKLNVDGVSHDVDADPDMPLLWALRDHLDKTGTKYGCGIAQCGACTVHLDGQPVRSCQT
RIGDVGEAKVTTIQGVSGRVAEAVQTAWRGLDVVQCGYCQSGQIMSAIGLLSTTPKPSDA
EIDGAMDGNICRCGTYQRVRAAIHEAARSLA
>C7C7Q8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)|TrEMBL
MIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHLGGTAARACIT
PVSAAEGQEITTIEGLSPDGNHPVQVAWRDLNVAQCGYCQTGQIMQAASLLKDSPKPTDQ
QIDENMSGNICRCGTYPRIRAAIHQAAGQAPATKGDRL
>F6ASW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Delftia sp. (strain Cs1-4)|TrEMBL
MQPGRRGRIGDPTMKFTLNSRSVAFDGDGQTPLLWVLRDHFKLPGTKFGCGISMCGACTV
HVDGEPVRSCVLPVSTVGGKAVTTIEGLSSNRSHPIQKAWMDKDVPQCGYCQSGMVMAAA
ALLKTHPQPTDAQIDEAMTNLCRCATYHRIREAIHAAASKQ
>A0A375FRP1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLDVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVKAAVGHAVTTLEGLGTAQHPDPVQQAFIEEQAAQCGYCLNGMILTAKALLARN
PDPDEAQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQATQGAAS
>A0A375EYE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSHLHTSRRRFLQAAGAVPAALVLGFHLPLAKAADAAAPARDPDDVNAWLRIDADGGVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQTWSVPVAQCRAVQGVVRHEPSGRTLGYGALAAQAAALPR
PANVALKDPRDWKLLGRPTDRLDIPLKTRGAAVFGVDVKVPRMLVGSVMACPVFGGTLRR
VDARPALALRGVRRVVPLDDAVVVLADSYWTARKGLAVLQPDWQLPQGQLAGDAALMAGY
RNAARSASAMALRHGDPDTQMQGAQAYTAEYEVPYLAHATMEPMNATADVRAERAEVWGP
TQVCGEIAQRLSGVLGMPAARIVVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDVRHDFYRPAAAARFSAVLAADAAGIRALDARLACSSIYVRNFPDRVKAGVDPKSV
EGVVDLPYALPHVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAKADPLQFR
LNLLADRPRPARLLQRLAQHVGWGSAPAGRFHGVALSQAWGSLCATVVELSVQGQRITLH
RIVNAIDCGTVINPATVERQLEGASIWGLSAAMTGAITIADGRVQQSNFHDYPLLQLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALTNALFAATGQRLRSLPLVRHGFELA
>A0A840HU13|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizorhapis suberifaciens|TrEMBL
MTRVRGNDEKCGGVSRRSIVIGGGAGVGLLIAWALWPRSYSPNLNAAEGEHVMNAFLKIG
RDGQVVVIVPQAELGQGVYTVLPQILADELGADWRTVAVQPAPISPIYANTLLAGEWLGN
DMPTLMGRAGDWAVRQYAIRNSVMLTGGSTSLRMFAGSYREAGAAARVLLCKAAAARWDV
DWEACDTKDGFVVLGDQKLRFGELAAEAAEYDAPDLLPLRPKSDDDLVGRDLPRLDVPSK
IDGSANYAADVRLPGMVFASIRQGPIGNATLKSFNEAEAKKVAGFLKVIKQERWVAVTGS
NWWAANKALDLLDPLFTMEGRLIDNSFIEQSLEAALDGGEGERFVHEGDLEAIFDGAQIV
ASEYQVAPALHLAMEPMAATAHVHDGEAEVWIATQAPAFTRAAVARALGLSEKEVVVYPM
LAGGSFGRKMEAEAAAQAAVISREMNRPVQLLWSRAEDIIHDRPRPPAHARMAAKLGRGG
FIEGWSAKVAAPSTLTETWARMADGVLPHEARARGGRTAERAAISGLVPAYSMGALAVDH
YPVDVGLPSGRWRSNADHYSAFFNECFIDELAKISGVEPMSFRMQMLSNNPRLAHCLSTA
AALGGWQGGIAGSGQGIACHSMSGSHIAIVVEASLAANRLSVGRIVAAVDCGMHVNPDIA
RQQIEGGLIFGLTSALGGVTPYRRGMPRKMRLGDLNLPRLADVGEITVEFIRSREDAGGV
GEVGVPAMAPAIANALFTVTGERFRTLPLLGK
>S2DN87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)|TrEMBL
MENYTLKINGESHQVTAEEDMPLLWALRDLLGMKGTKFGCGQALCGACTVLVGGEAMRSC
SLPVSAVGDQEVVTIEGLSAKGDHPLQSAWIEHVVPQCGYCQSGQIMNAAALLQRNPNPS
DQEIESVMAGNLCRCGTYNRIKEAIKTASSKL
>A0A679K3Q2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hyphomicrobium sp. ghe19|TrEMBL
MSSITINGEAHEFSGDPNMPLLWYVRDMLNLTGTKFGCGAGVCGACTVHLDGVAVRSCQT
TLGEAAGKSVTTIEGLSPDGEHAVQQAWRKVSVPQCGFCQAGQIMQAASLLAKNRAPSDA
EIVEAMAGNICRCGCYQRIHEAVRLAAGGV
>Q4KFS9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)|TrEMBL
MNRLPQDFALSNLSRRGFLKGVGATGALVLAASWGWQEAFAEDKKFGADGMPHGWVDDPK
VYVSIASDGSVTVICNRSEMGQGVRTSLSMVVADELDADWAQVKVRQAPGDEVRFGNQDT
DGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWQVPLAQCRAQLHKVVHQPTGRELGYGAL
AAAAGALAVPARDSLRLKQPGEFRYIGKEATRAIDGQDIVNGRAVYGADVHFDGMLFAAV
ARPRVYGGKVKSVDDSAALKVPGVIKVMPIDSRPLPSEFQPLGGVAVVASNTWAAIKGRD
ALRIEWEDGANAGYDSIQYRKQLEAAARQPGKVVRSTGNLDEALKGAESSLEASYYLPHL
AQAPMEPMVAVARFQDGRCEAWAPSQAPQVTRERIAERLGIGFEQVTVNVTLLGGGFGRK
SKPDFILEAAILAKAFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGLNKDGLPAAWLHR
TVAPSITALFAPGMNHEGAFELGMGFTNMAYAIPNVRLENPEAAAHTRVGWYRSVSNIPH
GFAIQSFVDELAHKAGQDPLQYQLKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRLRT
VLETAAKAAGWGRSLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHQADIAVDCGP
QINPERIRSQFEGACVMGLGNAVLGEISFKEGKVQQDNFHMYEVARMSLAPKQVQVHLVT
PPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQQASA
>A0A0M9GGN0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fuscovaginae|TrEMBL
MSRSLNDFALSNLSRRGFLKGVGATGALVLAATWGLPDAFAEGEKKYGADGMPNGWVDDP
KVYVSIDADGSVTVVCNRSEMGQGVRTSLSMVVADELEADWAQVKVRQAPGDEVRFGNQD
TDGSRSMRHWYEPMRRCGAAARTMLEQAAAQQWNVPVGECRAQLHKVIHSPSGRELGYGA
LAAAAGALAVPPRDSLRLKQPAEFRYIGKESTRAIDGADIVNGRALYGADIHFEKMVYAT
VARPRVYGGKLKSFDAAAALKVPGVLKVLEIEPRPLPSEFQPLGGVAVIASNTWAAIKGR
EALNIVWDDGDNARYDSVAYRQELEAASRQPGKVVRNTGNVDEALKGAASHFEAGYYLPH
LAQAPMEPMVAIARFNDGQCEAWAPTQAPQVTRERIAERLGIGFDQVTVHVSLLGGGFGR
KSKPDYVIEAAILAKAMPGTAVRVQWTREDDIHHSYFHTVSAEYLQASLNQDGTPSGWLH
RTVAPSITALFAPNMNNEAAFELGMGFTNMAYDIPNVRLENPEAKVHTRVGWYRSVSNIP
HGFAIQSFVDELAHKAGQDPLAYQLKLLGPDRQIDPRSLSEQWNYGESPERYPIDTGRLR
TVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDCG
PQINPERIRSQFEGACVMGLGNAVLGEISFKEGQVQQDNFHMYEVARMSLAPREVAVHLV
TPPGQVPLGGVGEPGVPPIAPALCNAIFAATGQRIRNLPVRYQLQGWNKAQA
>A0A0P7ZPU5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Porphyrobacter sp. HL-46|TrEMBL
MAVTLNINGKSESVDAAPGTPLLWVLRDHLSMTGTKFGCGVAQCGACTVHIDGAPTRACV
TPHDSLDGAKITTIEGVEGGAADAIRKAWVANDVPQCGYCQSGQIMAATALLRDNPKPDD
AAIDKAMSGNLCRCATYMSIRRAIKEAASMV
>A0A841HMH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MLNPQIDPLGESRDQKGTDASRRNFLKSIAAASGGLVIAMYLPGCSKTENAAKNAGPAKI
IEANAWLRIGTDGAITVLCDRSEMGQGVYTALPTLIAEELGVSPESIRIEFAPPGAAYVN
SLLGAQVTGGSTSVRDAWEKLRMAGAEARTRLATVAASNWGVPASRCSVADGYVVFTSRR
ASFGELAEAAAALPKPETITPIAKDQYRFIGKPQKRLDTPSKVDGSAQFGIDVRLPEMLY
AALAQAPELGATVESFDAEKAKTLPGVKHVVQTSAGVAVIADSWWQAKTARDAVAIKWKS
GPNAKLSNAAIYAGLKTAAAGQGKEVRNEGDAQMGLRGAVKRVDAVYELPMLAHATLEPQ
NCTVEFKDGNCHVYAPTQVQQLAQAVAAQTAGLPPEKVLVHTTFLGGGFGRRLDVDFIPP
AVECAKAAGKPVKLLWTREDDTTHDKYRPPARNSCSAALDSQGNLTTFKLQLVAPSITSR
WAPAVVKDIVDPFAIEAAHNYPYAAANVRVDYVQHEIGIDVGYWRSVSHALNCFTVESFM
DEVAVAAGKDPYQFRHDLLEKQPRWQAVLDATAKKAQWGRVAEGRHQGIALMSGYDTYLA
MVAEVSMAGNKLQVHKIVCAIDCGQMVNPDIVRAQAEGSIIFGLTAALYDDINIAGGKVA
EQNFNDYRLMRINEVPAVEVYLLESNEKPGGMGEPVVALVAPAICNAIYAANKKRLRTLP
VVKQGIVV
>A0A2X2G4H5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MKLPEVPLTRRRFIVGTGALVIGAYLPSTGALARTSPATAAENTTFEANAFVQIGEDGIV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDSNVYKNMSFGLQGTGGSSSV
ANAYEQMRRMGAMARAMLVQAAAQSWKTSAEEITVQAGKIRHAASGREAGFGEFAALATQ
LPPPDPATLTLKDPSHFTLIGKASGLHRVDSLAKTNGTAQFTQDIHEPDMLTVTIKKPPR
FGGKVASFDASRALTVPGVVAVKQTDTGVAVYAKNTWAAIQGREKLQVEWDDSQAERRNT
EQIYAEFRQVAQKPGAVAKSHGQPEQVFDKADKVIEAEYTFPYLAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDQIQLCNLFQLPPDKVEIETILAGGSFGRRIDLGNPQLGPDLAADM
AAAAKAIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRDGKVVGWSDTIVGHSWTLN
SAMTALVVNGVDQMMIEGASEVPYTFESFLCDAHIVPGKVPTTSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPREAGVLRAVAKAANWQGAKVVDGRARGVGVAKAFNT
RVAQIAEVSIGEGGIPRVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSIALYGNITLKD
GVVEQSNFNNYRPLRIDEMPEIEVIIVPSSEAPTGVGELGVPTIAPAVGNALALLGRPRS
SLSLPLHRPNSDASV
>A0A7R8L5E4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylacidimicrobium sp. AP8|TrEMBL
MAAAAEKAGWGRPRPGRQLGFAYHRCFGSHVAQCVEISVEPKGLILHRVVCAVDCGPLVN
PDTVKAQMESGIVMGLSAALKERILLEEGRVVSNNFDSYPILRMGEAPRRIDVFLIQGQK
ELGGVGEPGTPPAAPALANALFAATGRRAESLPLRLS
>A0A3G7JGP0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MNKPIDSANELLNLALDEPVNLSRRRFLTGTAVGALVLGFGLPLGSARALAATATAAERG
TQVPAFLEIRPDGTVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFVVEAAPPGEAYVV
MENGLRITGGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPVAELSTAPGRVLHAASG
RSLGYGELAGRALDMPVPDPASITLRDPSQFRWIGKPVRRVDAYEKSTGKALYSIDLKVD
GMLHAAVQHAPRLGMTVGSLRNEAQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEAIQ
VDWLEAAADSKVRTMPADFSSDAFRDFLAAQQGPARDDENEGDVAAALASAKTRVEATYH
NQYLNHAQLEPPSALARYNPDGSLEVWLPNQAPDMFRDDIARRTGLAASQITLHSPLLGG
FFGRHFLYDSANPYPQAIALAKAVGRPVKLIWSREEEFVRDALRPVAVVKFRAALDAEGL
PVAIEAVSATEGPTEAIAGKQGEKLDPSALEGLSGKSYAIANKRIAQIYVKGPVMLGYWR
SVGNSLNDFFYEAFLDELADKGGRDPYELRQHLLRDNPRLTTLLQAVGELSGGWKRGPFT
AEDGTRRARGVAMASPFGSYTAVIAEVSIEGGQVKVHDIWQAIDPGSIVNPAIVEAQVNG
AVALGLSQALVEEAVYVDGKPRARNYDLYPILPPSRMARVHVRIVESGEKMGGIGEPPLP
AVAPAVANAVARLTGQRIRSLPLSRYTFS
>A0A1X6YN14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax jejudonensis|TrEMBL
MDLTINGSSHTVDLPDDMPLLWALRDGLNITSVKYGCGIAQCGACTVHIDGLAVRSCQVA
LADVWGEITTIEGLGTPDVLHAVQEAWIQHQVPQCGYCQSGQIMQAADLLARNPEPTDED
IDAAMSGNLCRCGTYPRIRAAVHAAASVMREA
>A0A1K0IKN9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator|TrEMBL
MTTLNINVNGKTREVDVDPSTPLLWALRDNLEMTGTKFGCGMAACGACTVHVNGQATRSC
VTPVSAAAGARITTIEGIGTDKVGRAVMDAWLKHDVAQCGYCQNGQVMSAIGLLRAKPLP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A2P9AA63|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium delmotii|TrEMBL
MARLIINGTPRDIEVDPDTPLLWVIREQIGLTGTKYGCGVAACGACTVHIDGVATRSCVL
PVSAVEPDQQITTIEGLSPDSSHPVQQAWLALDVPQCGYCQAGMIMAAAGLLMQNPNPAD
EDINAEITNICRCGTYNRVRAAIKLAAKSGETTQRG
>F7S947|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidiphilium sp. PM|TrEMBL
MNAVNGVGRRVFLQGSGGLFIAFSLFGRAEAAEAPQKIGTVHAPPPADRLYAWLAVHPDN
TATLFTGKVDVGTGTETALAQIAAEELDFPVDRLGVVMGNTAETVNQGPSYGSRTIRYAG
PQIRQAAAAGRAALLDLAARHFGTKADALTVKDGVVSVKGAPGKTVTYGKLVDGKRLDMK
IGASGTSFGMKVAPQAKPKNPADYTVVGRSVPRKDIPGKILADFTYIQDVRVPGMLHGRV
VRPYGVHAKLESVDVSAVKDIPGFVQLVRRDNFLGVVCETEWGAIQAAAKLGSVLHPKGP
DAYPAKWSKWDGLPPMDRIWDVVRDAPGKTTMVANRGSVDNAMATAAKTLKATYQTPFQM
HGSIGPSCAVADVNKERAIFWSGTQMPHEARRDMAKLLGMKPDQIELRWFEAAGAYGRNG
LEHAVADAALMSQAVGRPVRVQWMRWDEHGWEPKGPPIAQDLEAAIDAKGNVTAWRHRMW
IPTFLDTTLIAAELIGRPDLVGSVGHGLPAITYAYQFENAEVSSHGDGKVALRTAWLRSP
AQYETTFAMESFIDELAAATGQDPLDFRLKHLKDPRAIDVLKAAAKQYGWKPRPARGRSP
QGGKPVTGRGIAWVNRDDSRVATIADVTVDPQSGTIRVERVVVAHDCGLVVNPDGIRNQV
EGNVIQSISRTLHEEVTFDRSHVTSRDWVGYPILRFSEVPDSIEVVIVNNDPKYPMHGAG
EPATCPTAAVISNAVYDAVGIRLRELPFRPDRVKAALGRA
>W0PJM9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Advenella mimigardefordensis (strain DSM 17166 / LMG 22922 / DPN7)|TrEMBL
MSNTTFHSELPRALQHILEQGQTASRPPLARRRFLKIVGAGGLAIGAFPHMLMAQEAEGT
AASVLKPGQQPSAFVHIAPSGEVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSSNG
SNDVAYQDPLFGMHLTGGSTSIKHSYTQYRELGARARAMLMSAAAQRWNVEVASLRTQEG
VVLGSDGRKAGYGELAEAAMALPVPEKVTLKDPKDFRIIGKATTRIDAKAKSSGQQDFGI
DMNLPGQLTAVVAHPPVFGGKLASMDDAAARAVKGVKAVLRVAVDGGGQGVAVIAEGYWQ
ARQGRDALKLQWDTSTVEKVDSEKQLTQYREMAETPGPRLYEADMSPLASAAHKLDAEFV
FPYLAHAPMEPLNCTVQTTEKGAQLWVGTQMPGFDAMAAARVLGLKPEQIQVHVQTAGGG
FGRRGVGTSDFVVLACEVAKAARTAGLDAPIRTLWSREDDIKGGYYRPVHLHRARIGFDD
NGKVLAWEHALVGQSIVAGTPLESMIKNGIDSTATEGMRDPYPIPMQLTVHHPKVNVPVL
WWRSVGSTHTAFVMETLIDDIARTTKQDPVAYRMALFGDKSPRHKAALQLAVEHSGYGKT
ALPEGRAWGVAVHESFSSVVAYVVEASVKDGKPVLHRATAGVHCNLTVNPRSVEAQVQGA
AIMGLSMCLPGAAITLKDGVVQQSNFGDFSVPRITDAPEIAVHIVPSAEPPTGMGEPGLP
PLAPAFANAIASITGKPLRTLPFKLS
>Q399E1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MTDITINGQRHQFAGDPDMPLLWYLRDELGLTGTKFGCGMALCGACTVHVEGQPMRACVT
PIGTLAGRNVTTIEAAHEKKVGQAVQKAWIDEQVPQCGYCQSGQVMSAVALLTVKPDPTD
GDIDAAMSGNICRCATYQRIRVAIHKAAENLKA
>A0A7W8VYZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. Cpub6|TrEMBL
MAVLNINGRKVKVDADPDMPLLWVLRCDLGMTGTKFGCGVGICGACTINLDDAACFACQT
LMSSLHTQKITTIEGLQGREAQALKAAWIELDVVQCGYCQSAQLMAACALLKHKPDPTDA
DIDEAMTPVVCRCGTYPRVRAAIHQAAAKVRKS
>A0A0E0UPV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium meliloti (strain BL225C)|TrEMBL
MVTVKINGVEHKIEAEADMPLLWAIRDLVGLTGTKFGCGMAQCGACTVYVDGSPTRSCQT
FIGDIEGAEVTTVEGLKGKVAETVQAVWADLDVPQCGYCQSGQIMSATDLLANNPKPTDA
DIDAAMSGNLCRCATYHRIRAGIHEAAKRLEA
>A0A7W6GSN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sagittula marina|TrEMBL
MAYTLTVNGTTHEVDLPGEVPLLWVLRDQLNLTGTKYGCGVASCGACTVQVDGQAQRSCV
LRLEDVDGEVTTIEGLGQPDTLHALQQAWIDHQVPQCGYCQSGQIMQAASLLAELPSPSD
EDIDNAMAGNLCRCGTYPRIRAAIKSVAEGV
>A0A6S6YJM1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter pestifer|TrEMBL
MTQLQINGQAKDVDVPGETPLLWTLRDELGMTGTKFGCGMALCGACTVHMDGAPIRSCVT
PLSAAAGHSITTIEGIESDAVGRAVQQAWIEQNVAQCGYCQAGQIMTAVSLLKTAPQPTD
QDIEDAMSGNICRCGTYPRIRAAIQQAAKRLAQGDKQ
>A0A7W6CHU3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MAITRRQWLIGAAAGGGLVVGWSLLPRHYAYPFPPEEGEYPFDAWLRIGKDGVVNVAIPQ
LEMGQGVMTVLAQIAAVELGADWRQVAVTPAPISALFPNLPLAASWAPLWAPIVAPLVAD
RHSWMVRRWAEDHRFMATGGGTSVTAYEEPLRKAAAGARAVLAMAAAARWGVKWEECEVS
GGAVRHGGRSFGFGALVQDAAGLTPPDPPVLRPAPPAESPAALPGGAELAFPRLDAPAKV
DGSWPFAGDIRLPDMLYAAIRHAPRGENIALGAHDAGRAHGVSGFVRMVEGPRWVAAVAT
DWWAAEQALAKIAPGFAVEKPLESADITKALDEALKGDDAHRMVAQADADGILGAHPQFS
ARYDIAPAVHATLETATATARLREGMVEVWAATHTPERARLAIARELAVPAHQVTLYPAA
AGGSFDARFDARFAIQAAAIAQAVGKPVQLIWSRWQEHVAGLPRASMAVHVEARADTAGH
VAAWRAKIAMPATMREFGLRMLSGASPTKAAKMQDRKDIMAMEGANPPYAIAHVAVDHAP
VATGLPTGLMRGGPHGLHAFVSESFLDEIAAALGREPLSFRMGMLAGDPRMAACLQRVSA
LAEWNGGKDGSGAGLACHRMGAVGDGGCIAAIATARRSDAGVRVDRITAVADIGRIINAD
IARQQIEGGLIFGIGLALGASTGWEKGLPVLSRLGQLGLPLLADCPEVEVELIASGADPF
DPGELGVAVAAPAIANALFSATGIRLRRLPLASDD
>A0A7W9F050|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Loktanella ponticola|TrEMBL
MASIGKIARRTFLIGSAALVGGVAFGVYKVKQDAPNPLVTANGESTLNPFILINADGVTI
ITPRAEMGQGIQTTLAALVAEEMDLNWDDVRVMHGPPAQAYYNSALLGVALPYHIYADSE
FMTGVRDNLGQVGKLLNLQVTGGSSSSRDGYTRMREAGATARETLKLAAAKRWDVDVSTL
TTENGHVIAADGEKLSYIDLAADAAQIDPPSVDLRAKSEWTKLGTPMPRTDMVAKSTGTA
TYATDVPLEGAKFATVRFNPARSGMVSFDASAALEMDGVDNVLDLGDGIAVVASNTWLAF
QAAEMVEIAWEAASYPATSDAMRDAITASLSSEPNSTTRDDGDVDAAIDGTEITAGYSVP
WLAHATMEPMTTTALYANDALTIWSGAQAPILMQEKCAAVVGLTPEQVTVNTMYMGGGFG
RRTESDAAVQAAQIAKQYPDTPIKLTWTREEDMRHDFYRPAAAASFRGVVKDGEAVLLHG
KIAAPSVTHQSTFRMVGQVPPGPDRAHVEGAADQPYGIENFRLTGHLTDLDVPIGFWRSV
SASFNGFFFDTFIDEMANAAGADPLKFRLNLAAKEHAASAAVIAKVGEMANWTGQTPDGV
GRGIGFTYSFGTPVAEIVEVVDEDGAIRINKCWIACDVGTALDPSIIEAQMISGAIYGMS
AAAQGEISFVDGAADQWNFPDYDALRMHNTPDFEVAILETGHAIGGAGEPGTPPSMPALG
NALFDLTGTRATSLPLIKTFNLIL
>A0A840HGC7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ERR14|TrEMBL
MATVLTINGETKSFDAPPEMPLLWVLRDILGMTGTKFGCGIAQCGACTVHVDGKAVRSCV
LPVSAVENRAITTIEHVGSTPAGAKVQKAWLDLEVIQCGYCQSGQIMSAAALLAATPNPD
DSDIDAAMAGNICRCGTYVRIREAVKQAANGRQS
>A0A238JD70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas phthalicica|TrEMBL
MTINLKLNGVEHSVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHVDGEPARSCQ
TFIEDVEGAEITTIETIGDTPEGAAIQQAWKELDVVQCGYCQSGQIMSAVGLLQENPKPS
VEEINDYMNGNACRCATYQRIRAGIQRASEILEA
>G8T805|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Niastella koreensis (strain DSM 17620 / KACC 11465 / NBRC 106392 / GR20-10)|TrEMBL
MASYNLSINGTSHAVEADPKMPLLWVLRDLLSMTGTKYGCGMSQCGACTVHLNGNAIRSC
SMPVSAVGNQKITTIEGISTNNTHAVQQAWIAEQVPQCGYCQSGQIMSAVALLKRNPNPT
DRDIDLAMQGNICRCGTYPRIRKAIHRAAGMMKQPAKGF
>A0A7W6DNT9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium fontiphilum|TrEMBL
MSAATLSRRSFISASLIAGGGLLFDLNVPLARAADGTPTILTAFIRILPDNRVIIGAKNA
EIGQGAKTMLPMLIAEELDVDWAQVTIEQTHADQSIFGGQVAGGSRTTPREWVPTRRAGA
AARAMLVSAAAAQWGVPAERLKTASGKVSDPASGKSLTYAALAVAAAKLPAPDPEKLTLK
DAADFRIIGQSIIGPDTPAIVAGKPLFGIDFKLPGMLYAVIENCPAFGGTLKSANIDEVK
ALPGVAHVLTIKGDGQPESLFDGVAILSKSWWSANKAREALKVEWDDSAVSGFSTEGYAK
QAAARRTGKADGDIIRKGDVDAAFAAAAKTVKADYSYPFLAHGTLEPQNCTALFKDGAIE
IWAPTQYPENGRSLVAKALNLPPEKIRINFTRIGGGFGRRLMNDYMVRAAVIAAKLPGVP
VKLLYSRQDDMRRDFYRPAGWHGFRAALDAKGKLTAFHDHFITFGKDGEPVRAAEMPEYE
PPVEFVDNVVMEQSFLSTNMPTGWLRAPGSNALAFVTQAFLDEVAQAAGKDLPTLMLELL
GADREIPRGDRSPPFVTARAKAVIEKVCAMAGWDQRARMPKGSGKGFAFYFSHMGYFAEV
VEVAIVDSMPKVKTVWVAGDIGSQIINPLNAMHQAQGSVIEGLTQALAGQSITQVAGAVE
QSNFDGHPLLRIPDTPDILVEFIRTDYPPTGLGEPALPPVIPAMVNAVHAATGRRIRSLP
VTPDMLA
>A0A509ECP2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MLKIRQPTPSPRASRRAFLTGSAAAAGALVIGFRLDLRGARAEGAPALSAVKANPNAFVR
IAADDTVTVMIKHLDMGQGNTTGLATILADELDADWSKVRTEFAPADAALYNNLLMGPIQ
GTGGSTAIANSWMQLRKAGAAAREMLVAAAALDWKVQASQITVESGVVRHAGSGREARFG
ELAAAAAAMPVPQEPRLKDPSQWRLIGQKALRLDSVAKTNGSAIYSLDIRRPNQVTAVVA
HPPRFGATVKGFDDKAARQVAGVIDVVAIPTGVAVIARDTWAAMKGREALKVTWDESLAE
TRSSDVILAEYRETAKRPGIVASQRGDAEAGIKGAAKVLEAEFSFPYLAHAAMEPLNATI
ERAADGSYDIYAGLQFQTIEQATAAAILGTTPDKVRLHTLWAGGSFGRRATPSADYIAEA
AAILKAWGAKAPVHLVWTREDDMAGGYYRPTVYHKIRAGLDAKGSVTGWQHVMVGKSIMI
GSPFEAMLVKNGVDGTTVEGASDTPYALPAYRFEVHNAREGVPVLWWRSVGHTHTAQAME
VFVDELAHAAQVDPVAYRLALLTNAPRLSAALKLAAEKAGWGKAAPEKGRAMGVAAHESF
GSYVAMVADVTAGSGSLKVNRIVAAVDVGIAVNPDIVRAQVEGAVGFALSSVLRNRVTLK
DGVVQETNFDAYEPTRLTEMPVVEVHIVPSQAAPTGIGEPGVPVLAPAISNAVFAATGQR
LRALPLDLSGLKGV
>A0A0D6SXJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. FeS53a|TrEMBL
MITLNLNGQDTALDVAPDMPLLWALRDVAGMTGTKYGCGMSLCGACTVHVDGQPTRACVT
PVSSVVGRKVTTIEAVAENDVGRAVQAAWRKLDVVQCGYCQSGQIMAATALLSGNRTPTD
ADIDAAMSGNICRCATYVRIRAAIHEAAGQLA
>A0A3P5WDV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Xinfangfangia humi|TrEMBL
MSFTLNINGNEMEVDAAPETPLLWALRDHLGLTGTKFGCGIAQCGACTVHVDGVATRSCQ
FPVEAAVGSEITTIEGLDPQGGHVLQKVWTEMNVPQCGYCQSGMVMAVASLLKDIPEPTD
ADIDLYVDNICRCGTYPRVRAAIHRAAELMKA
>D4X3L1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter piechaudii ATCC 43553|TrEMBL
MNVNGCECDVPAPSDTALLHVLRNDLALNGPKYGCGLGECGACTVLIDGVAARSCVIPVR
AAQGRAVTTLEGLGTRQQPGPTQQAFIDCQAAQCGYCLNGMIMTVEALLRRNPNPSEEAL
RNELHHNLCRCGTHVEIMQAALRAVRLRAGGDGASGLIAPHAVDGGPAR
>A0A7W6RI87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium mongolense|TrEMBL
MVTFTLNGQTKTFDGDPDMPLLWFLRDFEKLTGTKYGCGVAQCGACTVHMDGFTRRSCIT
PISAVESSEIVTIEGVEGKEAEVVRAAWVAIDVPQCGYCQSGQIMSAVSLLQNVPKPTDE
DIDGAMAGNICRCATYHRIRQAIHNAAAAMEG
>G3A6T7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia syzygii R24|TrEMBL
MNADATAPHRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQAGEVALSGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVSVESSPIERIYGNLIVMGDSAL
PLHPDDADKAWARALHWIMAKSAREIGLIITGGSSSVADAWQPVREAAATARATLVDAAA
REWNVPAAQVSVRDGRLIGPGGQQAGFGAVAQRARNIAPPASVTLKPASQYRLVGKPAPR
NDVAGKTDGSARFAIDARPPGLLYAAVAMCPMFGGKLKAFDAKAAQGMPGVRHVVPFDGA
AGGAPGVAVVADHYWQACQAVEKLAPVWDNGPHATLDSAGIRRQITAALDGDRGGFTYRS
TGDGLKAFDNVSGATVVEAEYSVPYLAHAAMEPVNCTAQVTRDRVQLWAPTQVATLAQLV
AARAAGVSRDQVYIEIPLIGGGFGRRLESDFIGQAVTIAARTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIENGKVTAMASRSAGQSILAGELDRLFGAPSLGVDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEAAAAAGLDPLAMRRDLLKAHP
RERTVLDTAARAAGWGQPLAPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPGIVAQQVESAIIFGLGAALYGQIQVKDGRVVQSNYPDYPVLRMAETPI
IETHLVPSTAQPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A087PR08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MTRKILPTSRRALLGAALSGGGGFLLSAFLPGLPLLKASHAQDTATGVVFRPNAFIRITP
QGSVTLIMRYAEMGQGIYTGISMLLAEELGVTLDQVSVEAAPADPAYVDSVAGEEETGGS
SSTRDSWIPLREAGAAARMMLVSAAAKTWGVPENACQARDGRVFHSASGRGLSYGELAEA
ATHQPVPAKVSLKPASDFTLIGTSPRRLDTKAKTNGSAQFGIDAQIPGMKIGRIMACPVK
GGHLSGYNRAAALAVAGVVDVVTLPDAIAVIGEHMWAAIKGMEAAFPQWEYGPNATTSTA
DILAQMKKASEQSGVVAVKNGNAEEALKQAHTRIDAVYELPFLAHAPLEPINTTLHIRPD
GADVWVGTQVPGRARQEVADATGLRPESIAVHNHLIGGGFGRRLDSNSIGQAARFAKQVP
YPVKLIWTREEDITQDQFRPYYYDRISAGLTQDGAISGWHHRTTGSSVTARWYPEGMQNG
LDPDAVEGAAQTPYAMPDQLVEFVRDEPDAVTTLWWRGVGPTHNVFVVESMIDELAHQSG
QDPLALRKKLAAHQPRALKVLNEVEKQSGWGRALPAGHGMGIALHYSFQTWAATVLEVAV
EKNGQIRLVQVHSAVDCGPTVFPDGIVAQIQGGLIFGLTMALYNEITLKDGRVEQTNFHN
YRMMRLNEAPDIQVHLVSDPDAEIGGIGEVGTVAAAPALANALFAATGKRLRRIPFAKQL
GGEKA
>A5EU48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MNQHVKAAPSMAPDLSRRSFLVGTAATGLVLGYAGLADGALAATTPASFEPSVWYSIAPD
GLVTVTCGKADMGQHIASTMAQIICEELGAAWKDMRVQLASNDPKFNDPVLGAQITGGSW
STMMNFDAMSRAGAAGRIALTEAAASVMGVTAKELVVRDGVVMHPKSKKQMSYAEIVKSG
KITKSFTADELKALTLKTPDQYTMIGVSVPQLDIPAKTNGTAKYGIDTMLPGMVYGKVVT
PPVRFGATVKSVDDSEAKKVPGFIKAVVLDDKTGSTSGWVVAVASTFANAKKAADALKIS
YDKGPYANVSTDSIITEAMRLQAQDDAGQFFVKDGDANAALAGAAKVLEAEYTTSINIHA
PMEPMNATAEFKGDILHIYSGNQFATRSGAIAAGAAGIDPKYVVMHQAWLGGGFGRRLDA
DMMVPAVQAAKAVGKPVKVIYSRENDMTMDYSRPLTYQKVKAGLDSNGKLIALSHDVVSA
WPTARWGIPDFLTPSVDKKGPLDSFTVNGADFFYTVPNHHVRAIKNELAHNATPSGQLRS
VAPGWTFWAVESMIDEIAAASGQDPAQFRIALLDGKGKNDGGAQRLRNTLLAAMGLSGYG
SKKLPKGEGMGVACVSSQERASASWTACVAHVAVADNGAVTVKKLTVATDVGTQVHPDNI
RAQVEGAALWGLSLAMYEKATLKDGGIEQTNFDSYTPLRMSQVPEVAIAVIANGEKATGV
GEPAVTVVAPALGNAIYNACGARLRSLPITAEAVKANMKA
>H1KSG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens DSM 13060|TrEMBL
MNDLTPHHRLGIAARPQSEPVRNLSRRGFLGIASGALLLGIDLSKEAVAQTRAEGPAAVA
AKPGTRVAAFLEIRPDGGVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFTVECAPPGP
DYAVVNGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAARLAVPQDSLTTDDGRVIHA
ASGRTLGYGEVAQAALALLPRDDVALKNPKDFRWIGRPVARLDMRDKATGRATYAIDIRL
DAMLHAAVQHAPHLGTEPRAVANEAEVRAMPGVHSVHRLPGAVAVLADSWWRARKGAEAL
QVTWSEPAPEGIATVSATFSSAAMLAALKGTTEPSLPAEQEGDPGAAFANAAKVIEAEYD
APYLAHAQLEPPSAVARFTADGSLDLWVPNQMPELFQQIAAKTAGLQPEQVRIHSPMLGG
FFGRHFAYGPANPFPQAILLAKATGRPVRVLWSREEEFGMDAVRPLSFARFKAALGPNGM
PVALQTTAVGEGPISRWFGALFTSPVDSSVVEGLDKKPYAIPNRRLDYVRVAHPVTIAFW
RSVGHSMNDYFYESFLDEIAAAGGRDPFDLRMALLANSPRHATLLRKVAELAGGWRRGPF
AAEDGTRRARGVSMASPFGSETATIAEVSLEDGEARVHDLWIAIDPGSVVNPAIVKRQVE
SAAALGLSSTLLEQVVYENGQRQARNFDTYPILDRTRMPRVHVAIVESGAPMGGIGEPGL
PGVPPAVVNAVAVLTGQRVRSLPLAKTRLSGV
>A0A252ERX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella putrefaciens|TrEMBL
MSTFTAVENISRRDVLKLFGAVGGGLALGASGLSWSPMALAQDQQARLNLFIAIGEDDKV
YLTCHRSEMGQGIRTGILQILAEELEADWDKIVPIQGLADKRYASQNTDGSRSIRENYDR
MREMGAMARTMLEQAAAARWKVPVSEVQAKDHQVLHAKSGRAARFGELALDAAGLPLPAA
DSLRLKAVKDFKQIGASRQIVDMQAMLTGKAVYGYDIQVDNMLYASIMRPPVLGSDVASL
DDSAARKVAGVVDVYRLPTSKGAPAFQALGGVAVVATNTWSALQGRKALQVSWTQSVNSS
HDSKTYLKELVDKVQAPGKVVRQVGDEVKAWPKDDTLKAIYTVPYLIHSSIEPPVATANV
TEKGCEIWASTQTPQSTQQNVAAALGIAEDAVKVNVTLLGGGFGRKSKPDFSVEAALLSK
QFKRPVKVSWSREDEIQNGYYHAISAQCYQALFDANNKPTALLARTGFPSISSTFAEGVE
YPSGGELDLGFVDVPFALANLSYEAVKATAHSRIGWMRSVCNIQHGFGVGSFVDEMAHKA
KLSCPDMWRSLLGQARRETFENQGFKYGNYGEDLNRHPVDVGRYLKVIEAVEQAQAKAPK
AGKNQGWGFAVHRSFVSVVAVAMRVEVGEDKQLKVLNAIAAIDAGTVVNPDRVKAQTEGA
IVFGLSLALMGEISYQQGKVMQSNFHDYPLLRLPQVPEMEIIIIDSDAPPAGVGEPGVPP
VAPSLTNAIFAATGLRIRDLPVNKQLKV
>W8SPB7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibacterium elongatum DSM 19469|TrEMBL
MPTTLTVNGTQHSVDLPDDVPLLWVLRDELGLTGTKYGCGVSSCGSCTVQIEGEAVRSCQ
IALADVWGPVTTIEGLGTPAAMHAVQAAWVAHDVAQCGYCQSGQIMQAAALLAENPAPSD
DDIDAAMWGNLCRCGTYPRIRAAIHTAADALRREG
>A0A0J6EVI4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella pseudohinzii|TrEMBL
MMDTANFSRRSFLQGGLGALTLAVTAKGLITTVWAAETAPRKYGADSMPGGTVDDPLVFI
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWDRVKVEQAPADEARYGNQNVDGS
RSVRHFLMPMRRAGAAARQMLEAAAAARWAVPVAEVKAVQHEVVHQPSGRRLAYGELAAE
AAKQPVPKGEALKLKERAEFRYIGKDQVRLVDLEAIGKGQATYGMDVRLPGMVYAVVARP
PVVGGKLRRLDSSKALALPGVLKVVEIPPMQGAPAFQPLGGVAIVARNTWAARQGRDALE
IEWDDGPNAGYDSTAYRQTLEAAARKPGKTIRKQGDTAQTWGKAPEAERLASEYYVPHLA
HASMEPPVATVQIKAGKAEVWTSVQNPAAARDAVAARLKLEPANVTVNVLLLGGGFGRKS
KPDFVDEAAIVARAMPEGTPVKLVWTREDDIHHDYLHTVSVERLEAVIDKSGQVQSWLHR
SAAPTIASLFSEGAKGQQMFESAMSAINMPYQIPNVQVETAEVEAHARIGWFRSVANIPH
AFAAQCFIDELAHKAGKDSRDFALDLIGPARRIDPGSLADTWNYSESPERYPYDTGRLRG
VIEAACKGAQWGRKLPKGHGLGLAFCYSFVSYTATVIEVAVDEKGELQIIAVDMAMDCGP
QINPERIRAQMEGGAIMGLSLALTSEISFEKGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHALPPGGVGEPPVPPVAPALCNAIFAATGKRIRKLPVRRIA
>W7WMD1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium sp. T29-B|TrEMBL
MPVGYWRSVGHSHNAFFLESFIDELAHAAQQDPVAYRLALLAGSPRHAAVLQLAAAQSGW
GRPLPAGRARGVALHESFGSIVAQVAEVSLAAGGVPRVHRVVCAIDCGTVVNPGIVRQQM
EGGIVFGLSAALHGGIDIVAGVVQQKNFPGQPLLTLAESPRIETHLVASEHPPGGVGEPG
TPPIAPAVANALFVLTGVRRRGLPLRG
>A0A7Y7LR69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. SG517|TrEMBL
MSAAAGTVSRRAALQAGGLALAFTWIGGGKAFAAISPRQQPGDAAAALADGNPAFAPNAF
IRIDADGGVRLVMPMAEMGQAIYTGSAMLLAEELGVELDQVRVEHSPANEALYGMPLLGG
QITGGSTSTRGTFGVLREAGAVARTLLVSAAAAQWKVEPESCTVARGVVSHAASGRQLGF
GALASAAAKLPMPAKVALKEPKDFRLIGQPLRRVDSSGKVDGSVQFGIDVRVPGMKVATV
KASPTLGGVLASVDDKAARAIPGVIDVLRVKDAVAVVGEHFWAAKRGLEALKLQWTPGRN
ATLTTQQLRDDLANALAKDKAIVGKETGKRPDGTLVQSTYDLPMLAHATMEPLNTTVHVR
PDGCDIWVGTQVPARCVSVAAKITGLAEDKVVLHNQYLGGGFGRRLETDSVEQAVAFAKQ
VPYPLKVVWTREEDIRHDIVRPMYHDEISAVVDGEGRIRWFGDRISGGTVLGRWAPAFMG
KDGMDSDLIECVAEPCYDLPNLKVEWVRHDMPPGLNVGWWRGVGPTHNLFVMESFIDELA
HRAKKDPVAYRRAMLQKNPRTLAVLDLAASKAGWGQGTLPTRVGRGVAVGDAFGSRVCAI
VEAEVSPQGEVRMRRAVVALDCGIAVNTGSIEAQIQGGLLFGLSAALYSEITLRDGAIEQ
SNFHDYRTLRINESPPIELHMVKSAEAPGGLGEVGTAIAAPALANAIFAATGVRLRSLPV
NRALLAQDKEAMKKKIAEAPLDEGRSA
>A0A0P1IK14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shimia thalassica|TrEMBL
MKLVVDGKSHDVDVEDDMPLLWVLRDELGIKGVKYGCGVAACGACTVHIDGVAVRSCQTA
ASDVDGEVTTINGLGQPDALHAVQEAWIEHQVAQCGYCQSGQIMQAASLLAETPNPSDDD
IDEAMSGNLCRCGTYPRIRAAVKTAATKIQGA
>A0A3G8CA15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R4-34-07|TrEMBL
MSRLPADFVLNNLSRRGFLKGAGATGVLVIAASWGLPDAFAADAVKQYGGDAMPHGLIDD
PKVYVSIATDGTVTVVCNRSEMGQGVRTSLSLVVADELEADWAKVKVQQAPGDEVRYGNQ
DTDGSRSMRHWYEPMRRCGASVRAMLEQAAAEQWKVPVSECRAQLHKVIHQPSGRELGYG
ELATAAGALAVPARDSLRLKQPTEFRYIGKEGVKAIDGVDIVNGSAVYGADVHFDGMLYA
TIARPKVYGGKVKSFDASAAMKVPGVIKVLEIDSRPIPSEFQPLGGVAVVASNTWAAIKG
RDALNIVWDDGVNAGYNSVDYRKELEAAARQPGKVVRNTGTLDQAMGDADSTLEAAYYLP
HLAQSPMEPMVAVARFDKGQCEAWAPSQAPQVTRERIAERLGVPFDNVTVHVTLLGGGFG
RKSKPDFIIEAAVLAKQFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGLNKDGLPAAWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAAHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLQYQLKLLGPDRRIDPKTLSDEWNYGESPERYPIDTARL
RGVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPRQIAVHL
VTPTGEVPLGGVGEPGVPPIAPALCNAIFAATGQRIRNLPVRYQLQGWQEAKA
>A0A0H5D394|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter italicus|TrEMBL
MASIRKIARRSFLIGSAAIVGGVAFGTYKYHQPAPNPLEEKDGRAVLNPFVFVDQSGVTL
IAPRAEMGQGVKSSWASLIAEELDVDPAKVTVLHGPAAKAYYNSAMMSEALPGRGYDASD
FQHSLGEIVGHMSKFLDLQVTGGSSSMRDGFDRMRHAGASARETLKQAAADQLGVSRDQL
KTEDGHVVAPDGTRLSYSTLAAAAATIEPVETGLRPASSWRLIGKDVPRIDMVAKSTGTA
EFGVDVRLPGMKFAAIKQSPHFGVGITAFDASAAEGMAGVEKILDLGDAVAVVATNTWLA
QQAVDAIDVTWDPAPYPETTDAIFDEIARSFGNAPNSTMRDDRDVDTLPEGATVIEAEYR
LPYLAHATMEPMNATALYTGDGLQIWAPNQGPTVVQKNAAALAGLEKDAVEVNTTYLGGG
FGRRIETDYTDRAVQIALQMPGTPVQLTWSREEDMSHDFYRPGAIARYRAAVKDGKAVMV
HGKIAAQSTTVEGAGRMLGLPMTGPDKGHVDAAFNQPLAIPNFRVEGYLAKPMIPVGFWR
SVGASFNGFFSDCIIDEMAHAAGRDPLEFRLELARPEWEPAAKVLETVRDMSGWTGKTAD
GIGRGVALTYSFGTPVAQVIEVANQDGQIRMTNAWIAADLGRVIDPQNTRAQMFGGMVYG
LSAACFGEITFQGGAVEQQNFPDYDALRMHTMPKVEVALLENQPHMGGAGEPGTPPAAPA
LANAIFDLTGRRARQLPLMHDFDLFI
>A0A840SNR2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amaricoccus macauensis|TrEMBL
MVTFTLNGKDIAFDGDPDTPLLWVIRDEAGLTGTKYGCGIAQCGACTVHLDGMPRRSCVT
PVSTVEGSDVVTIEGVSGAEAAAVQAAWIGLDVPQCGYCQSGQIMSAVALLQLVPKPSDA
DIDNAMAGNICRCATYVRIRRAIHDAAATLEG
>A0A7X0PCS5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MVKRRTVLWGGVATAGALVIGWGALPPRQRLRTGQPLPTAGGQAALNGWLKIGADNSVTV
MMAKAEMGQGTHTGLAAILAEELDADWPQLRLEMAPIDDIYNNLATVVDGLHFHPDNDGS
IKAVAGWLTAKTMREVGVMMTGGSSSIKDLWLPMREAGASARAMLVRAAAAQWNVQAAEC
TVQAGVVEHAAGQRASFGELAALAAQQPLPGKVVLKEAAQFRLIGKPLTRIEARSKLDGT
AVFGIDANPPGLLHAAVVMCPTRGGKLLRMDAAAAEKLPGVKKVLAVDALNGGTGAVAVI
ADTPWHARKAAATVTVEWDHGPAAALSSAAVYEQLAQALDQAKGFGYHQSGDAPAAMQGA
ARTITADYRAPYLAHAALEPINCTVQFKDGAATVWTSTQVPDLARAAAAKVLGIAEDKVE
VRQLLLGGGFGRRLEVDYVAQAAAIARAADGAPVQTLWTREQDTQHDFYRPACMARFKAG
FDASGKLVAWDNLSVGQAIVPQVLGRIFGLPGAGPDKTTSEGAFDQPYEWPHARIAHEIV
ALPLPVGFWRSVGHSHQAFFKESFMDEAAAAAGQDPVAFRAGLLQKHPRHLQVLQKAAEL
AGWGQPLAADASGAKRARGIALHQSFGSIVAQVAEVSVAADSKAIRVHRVVCVIDCGAAI
NPNLITQQMESAVVFGLTAALHGEITVDKGQVQQANFHDYPLLRMADCPRTEVHIVPSAE
PPEGVGEPGVPPIAPAVANAVFALTGQRLRSLPLRLA
>A0A846QWZ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saonia flava|TrEMBL
MTKIKTQYNRRSFIKVSAAASGGMLIGFSWLNGCKPNTSLDTGVAIPKEWFDINGYIKIG
DTGMVTIFSPNPEIGQNVKTSMPMIVAEELDVPWENVVVEQAPLNTGFYQNQFAGGSLSI
RLSWNALRMAGATGRRMLLEAAAKEWGVEVSSLTASEGVIKENSGERSVSYGEIASKAVG
IEIPEEVDLKDLKDFKLIGTSKKNVDGRKIVTGEPLYGLDFHREGMKLAMIQHPPAFGMT
VKDFNKEEIKNMPGVTDAFIIDTTIDEPGWFDEKGFNHLIAIVGDSTWELMQAKKAIKAE
WETVSEPENSDIHIEKLEKALVSGEVEESRKDGNADAAFKKAAKIIERTYSAPFIAHNTL
EPMNFFANVTENSAELVGPTQTPESLEGSVSKLLNMPLENITVDMTRIGGGFGRRLYVHF
GVEAAAISKKIGGPVKLIYTREDDMSQGTYRPTYRSTYKAGLDENNNLIAFSVKGAGLPE
GPVFPNRFPAGTVENYSAEKIKAETNVTTGAWRAPRSNFTAGAEQSFLDEVAEAAGKDPI
DFRLELFNRAINDPIGEKHDYEAERYAGVLKLVKEKANWGETKPGVHRGVAAYFCHASYV
AEVMDIIMENGQPIVDKVWCAVDCGIVVNKDGAKNIIEGGVVDGIGHAMYSQLTFENGTA
KESNFDKYQLIRHSQAPKKIEVFFVENEIDPTGLGEPGLPPAMAALANALYKATGQRHYH
QPFSTERKLVG
>A0A4V1ABW6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hydrogenophaga pseudoflava|TrEMBL
MLNITVNGKAASLDAEPDMPLLWALREDLQLTGTKFGCGMALCGACTVHLDGQPVRSCST
PLSAATGKKVVTIEAIGNSKAGKAVQAAWVKHDVPQCGYCQSGQIMSATALLTAKPRPSD
KDIDEAMSGNICRCGTYNQIKAAIKDAATALQGA
>I2GBE2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrisoma limi BUZ 3|TrEMBL
MAVISLTINGKKRTINADPQMPLLWAVRDVVGLKGTKFGCGMAQCGACTVHLNGKPIRSC
ITPVSTVANKKITTIEGVGSEARLHPVQQAWIEEQVPQCGYCQSGQIMSAVALLNTNPDP
TDAEIDQAMSGNICRCGTYNRVRKAIHRASDMMKESALKTK
>A0A0P1EJS1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shimia marina|TrEMBL
MTAHLSRRGFLKSAAAAGAALYIGANAKGVMAAASSADAALNPFVKIGADGRAIALIKHV
EFGQGPATGLTTLIAEELGVTMDQITYEFAPSDPQVYNNLLFGPFQGTGGSTAMANSWMQ
YRNAGAAAREMLISAAAKEWGVDAASLDIVDGMVTGGGNSASMGDFVAAAAEMDVPAEPR
LRDASEWKLIGNDATRRLDSPIKVNGQAQFAMDVHLDNQMVVMIKRTPQKGGVVASFDDS
AAKDVKGFIMAQALPTKHGVAVYAENTWAAMQARNAIEVEWDNSAAESRSSAEIKDEIMA
ALDAEPTYNVNKADRAAVKAAVDGAATVLEKTFYFPLLAHAPMEPLNCTIEQTAEGKIVL
HDGAQMPTGPHMAYQQIFELPADKIEINSMLAGGSFGRRATPDADYQVEAGLAFIMTDRS
RPVKLVWDREDDIRSGYYRPAVGHKVRVGLDENGTIIGWDHQVAGQSIMKGTAFEAMAVH
EGIDHSTVEGIADSPYTIPGQSLGLTDTKKATSVLWWRSVGHTHTAYVMEVMMDLAAKAA
GQDPVDFRLSYLTGGGEADRKAAVLKLAAEKAGWGNAPAGHTQGIAVHKSFGSYVAEVVE
ISGNNDDGIVIEKVTAAVDCGIAVNPDTVRAQIEGGIGYGIGHAMRDQITLDGGAVEQSN
FPDYEPLRISDIKEIETHIIASAEAPTGIGEPGTPPSAPALANAIAALTDDSQLIAELPM
AEAGVYFA
>A0A178X794|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. M39|TrEMBL
MSKHTFILNGKPVSVDVDDNVRLLWVLRDVLGVRGPKYGCGINVCKACTSHFNGKAFNPC
SVRVADIKATDEITTIEGLPDTVKADLHPMQEAWLDNDVAQCGYCQPGQIMAAVAKVKEA
KAKGREINDADLDEIRNVCRCGTYSRIREAIKAGAARM
>A0A3B0VQ58|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
ANESKLPVKVLWTREDEIKHGYYHSPSYQKLSGSLDANNKVSSWYHAMVNHPIGATFDPS
AKTAGSTDLGQGDMMFDVPNIKIALGETDTFMRIGWVRSVTNINNVFAASSFVDELAHAA
GKDSKDFLLELIGKDRTEDFAADGFKYSNYGESAETYPAETSRLKNVIAVAAEKANWGQD
LPEGMGLGIAAWRSFLSYIAVVVKVSTDGNKVKIEDIHMAVDAGKILNPDRVKSQMEGSA
IFGASLAFYGEITAKDGAIEQGNFDTYQMTRINQFPEIHTHIIKSDTIPTGVGEPGLPPV
APAICNAIFAANGQRHRRLPLKNLQLV
>A0A143PK69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteitalea pratensis|TrEMBL
MKATWTINGQRRAVDVPDDMPVLWVLRDILDLKGTKFGCGAGQCGACTVHVDGEPVRSCL
LSASDVGARAITTIEGISADGSHPVQRAWVELDVPQCGYCQAGQIMSAVALLKQKPSPSD
ADIADAMSDNLCRCGTYLRIRDAIKKAAANSGGSTAPSAGRAGQQEVRR
>A0A7W6DFY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MTDPSEKKSCFRLTRRRLILGGSLIGGALVVGYIATNPMQVAGAILQGGGDDPEPSAFGP
FIRITDDGWVTIVNKQQELGQGIHAGLAAIVAEELDADWDRVRVVDSRSNFRAYGPQMTG
ASNGIASNWDLMRNAGAAARAMFVEAAALRWSVPIGAITVRDGIVSQPGSNRAVTFVELL
ADASRLQPQQSPVLKRPADYRLIGTDKVRRKDSLSKSTGAQVYTQDIQRPDMLVAMVAHS
PRFGGTLARFDASDARKVKGVVDVFAIETGVAVVAETTFAAWKGRDALRIEWDDSEAETR
STHELVRYYHDIAAGRSDVEPAEFDSKGDDPEVPFDGDVADFAFDFPYLAHAPMETLDCV
AQVNGWDVSITSGAHLATVDQVYAAFAARTIPGKVDIEVVPAGGSFGRRGVLSSDYLVEC
VRIAKRTDGRPVKLMWSREDEIASGYFRPMSHHRVWVQLSPDGFPTRWRIHSVCQSLLPV
GPNSLATEGITHSPYFSTASTVDGKIFTPTFPVVVGLWRSVGHSYTALVMEHIVDQLARR
AGLDPAAYRRVFYEKAGDKRRLAVLDELCLRAGWGGPIEPGWARGLAIHEAFGTIVGQVA
EVRLVDDRPIVHRVVAVVDCGIAVAHDQIAAQMEGSIGFGLSAALYGAITLKDGIVQETN
FDRYLVVRMNEMPVVETHVIASTGRPTGMGEPGVAPIAPAVANAILALTGQPTSRLPFLD
RNARSNTDVSVQS
>A0A7W6ACC2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium brachythecii|TrEMBL
MIHDAKLMADIAANSSKAPALLDNVSRRATLGGLGALVLALSLRDARADEGQTKEQKEKK
YGADGMPHGWQDDPKIFVAIAADGTVTVTNHRSEMGTGVRTSIAFTVADELEADWSKVKV
IQAWGDETRFGNQDTDGSRSLRHFFQHFRHAGAAARLMLIQAAAKQWGVPVGEVTAENHV
ISHAKSGKKAGYGEFAAAAAELPVPPRESVVLKDPKAFRYIGKGKIGLIDNHDITTGKAI
YGLDTKLDGMLYAVVARPAVYGGKVKSFDDSATLKIPGVVKTVKIEGGEIPSEFMPLGGI
AVVAKNTWAAMKGREALKIVWDDGPNATYDTTTFRKELEAAARQPGKVVRNQGDVDAAMA
KAKTKLQAEYFVPHLAQAPMEPPAAVARVKDGACEVWACTQGPQAAHDRLMKRLNLPTDK
VRVNVTLLGGGFGRKSKPDYVVEAALCSEAVDGAPVKLAWTREDDLHHGYYHTISVERLE
AGLDDKGMPVAWLHRSTAPTIGSIFAPDPKHELPFELGMGLTNLPLNLPNVRLENPEASA
HVRIGWFRSVSNIPHAFAIQSFVAELAHAAGKEPLEYLLALIGPDRKIDPNTIGDVWNYG
EDPARYPIDTARLKGVIQAAAKGAGWGRKLAKGRGLGVAGHYSFVTYTAVAAEVEVDDRG
EVKVHAVDIAVDSGAQVNPERVRSQMEGAVVMGMGLALSSQITFKNGRAEQNNFDGYEVV
RIDAAPKDLRVHLLGSGDFNGPLGGVGEPGVPPVAPAIANAVFAATGRRIRQLPIKDQLS
S
>A0A839U8C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MAYNLKINGTAHSVDVDDDTPLLWVIRDVLGMTGTKFGCGAALCGACTVHIDGVATRSCI
TTVDSIGDSAITTIEAIGETPQGAALQKAWLDLEVIQCGYCQSGQLMSAAALLKETPKPT
DEDINSAMSGNVCRCGTYQRIRAAIKQAAEA
>A0A2Z4ULQ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobiaceae bacterium|TrEMBL
MDITVNGRSWQVDDTVADSPLLWVLRDELGLVGTKFGCGVGTCGACTVHVDGEAVRSCQT
TPTDVAGQDVTTIEGLAGTAPNANLHPVQQAWIDHSVPQCGYCQAGQIMSAAALLAENPA
PSDRDIDRDMSGNLCRCGTYARIRSAIKQAARNISPSANQDAS
>A0A0P1GHD9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tropicibacter naphthalenivorans|TrEMBL
MGIMDILNAAPTNVSRRGFLAGAGSLVLATSLPVRPARGQEASDAPAVQAFMELRADGTV
LLKSPWIEGGQGVYTAMAQIVGEELDLSPEHFEVEIAPPGGPFGINGGFRITGGSASTRS
SYTLMRRLGASARAMLIEAASAQLGIPAADLTTEPGVVVAPDGTRLGYGELASAAMDLPV
PTDVPLRDPETFRYIKAPTPRIDVRAKSTGQASYAIDVTVDDMLLAAIRHAPRLGLAPDA
VTNLSEIEAMRGVHSVHMLDGAVAVVANKFWQAQKALAAADITWTEGQAKWPMPADFSSA
RFRDTLAKASGEVTPVESNGDAASALDSAETVIEATYDAPFVVHGQLEPPSATARMNDDG
TLDLWLPNQAPEQFVGRAAEVAGIDGSQVRLHSQILGGFFGRHFLYETANPFPQAIKLAQ
ATGRPVKLIWSREEDFLRDAPRPLGLARFRAAVGPDGPTALNVEVVGEGPTGRWYNAPAG
RDPSATEGISGKPYAIANTQIGQLYLQNPAVIGYWRSVGHSMHDFMYEGFLDEIAQAAGL
DPFEMRLKMLENSPRHHTLLQRVGDLSGGWQPGPYAVDGVQRARGVAMASPFGSEAATIA
EVSLDLGTVKVHNIWTAIDPGQIVNPAVIEAQVQSATALGVSQTLVEELVYENGEPTARN
FDMYPILRPDQMPDVHVEIVESGAEMGGVGEPGLPTVGPAIVNAVAQLTGRRVRSLPLSK
HDFG
>A0A841IVP2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium subterraneum|TrEMBL
MNSSTETEAQKPASKSKLRTFGRRAFLVGSIAVAGGVAFGYYVVRKPHDNPLLDDLGADE
ATFNPWVKISPTTITLITPHVDLGQGVASMQAALIAEELDLELGQFTTASGKPSPAYYNT
AMANDTVPFRSTDHGFEAEAMRGVMGAAVKVMGMQSTGGSSSTADSFDKLRAAGAVARET
LKQAASNRTQIPVARLRTAAGAVILPNGSKIPYTDLAKEAAKIPAVTQVTLRPPSQWRLI
GKPMERLDIVAKSTGTQIYGIDVDFEDMLYAAVKVSPRIGAGLVRYDASAAKQMRGVKRI
LDIPNGVAVIADNTWRAFQAANAIIFEWAASKAPEQAEHWKEVGRSFTEERLDKEWRNDG
DVAQAMKQEKIVSAEYRAPYVAHQPLEPLNAVIRVTGDRVDIWTSHQAPGVAQQKIAEVT
GLPVEGVRLHNQYAGGSFGHRLEFDYIILAAEIGRQMKNKTIKLTFSREEDFVHDYPRQI
SMARPRGSVKNGRVESYDLPIAAVSAARSYTKRLGMPVPGPDLMLAAGAWDMPYNIPNFR
VTAYAVPEIVPTSSWRSVGASTSGFFADAFLDELIHAAGADPMAERLRLVNDISARRVLE
AVAKMSKWGSALGPNRGRGVAMVTAFGVPVAEVIEVLATPEGVKIEKVYVAAEVGRIVDP
VNFENHVQGAVVWGLGHAMNCEITYSNGQIQQENYHAHEAMRLHQCPEIIVQGLENGGEI
KGIGEPPVPPAAPALANAIFAATGKRIREMPFNKHIAFV
>A0A378Z3Q4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea pulmonicola|TrEMBL
MVSFELNGRPVQVDVDPATPLLWTLRDALSMTGTKFGCGMALCGACTVHIDGAATRSCVT
PVSAVAGKKVTTIEGAGTDPVGRAVQEAWVKHDVPQCGYCQSGQIMSAAALLRENKKPND
EQIDAAMAGNICRCGTYARIRAAIKDAAASLA
>A0A127MT66|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas citronellolis|TrEMBL
MIKLKLNGKDHEFDAPGEMPLLWALRDVALLTGTKYGCGMALCGACTVHVDGQPTRSCVT
PLAAVAGKQVATIEAVAEQAAGKAVQEAWRKLDVVQCGYCQSGQIMSATALLAGNKSPSD
ADIDAAMSGNICRCATYVRIRAAIHEAAQNLA
>A0A0U5BLS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ghanensis|TrEMBL
MLTLNINGQSHQVDVDPDTPLLWVLRDVLGMNATKFGCGIAQCGACTVHMDGRAVRACNL
PVGLIGDQHISTLEGLDTTDPVAKAVQTAWIALDVVQCGYCQPGQIMAAVALLRSVPHPT
DEQIDSAMSANLCRCGTYMRIRAAIHHAAGELA
>G7FY06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas sp. BSi20495|TrEMBL
MSQDNKYFDLNRRKFLKTSAIGALVLGTYFVGSAPRAIAGVLEQPSEQAKRANLFIALRP
DGMVEITCHRSEMGQQIRTAIAQIVADEMEAAWDKVIVIQGKGDPKYGDQNTDGSRSIRY
NMQRLREMGASVRYMMQHAAAKFWKVDPQTCTANQHVVTHSSGKSLTYKDLIDLALTITP
PEADKLTLKTRKEWRYINIGMAHIDLADLVTGKAIFAADVREPQALVAIIERPPVVGGVV
KSFDASATKAINGVVDVIEIPAPKGAPQFQPKGGIAIIAKNTWAAWQGRKALKVVWDDGK
NGDYNSEEFKKSLLQTVQTPQANIRDKGDAMGVLAKSSNKLVADYYAPHLAQAPMEPPCA
TAMYNKDSVDIWAATQNPQADMKTVAAMLGMDESKINVHVTMLGGGFGRKSKPDFSAEAA
YLSMKVGKPIRVQWTREDDIQHGFYHAVSAQHIEASLDKNGAIESYLHRTAFSPITSTFS
EGATTPGSFELRLGFTDNPINTPNMKLENGDAPAKARIGWMRSVSNIFHAFAIQSFIGEA
AHKAGRDQKDYLLDTIGPSRIVDVTEQNATYDNYGGDKAVYPLDIGRLRHVIEKVADMSK
WGRELPKGRGLGIAAHRSFLTYVATVVEVEVSDAGDLNVIKSWVAIDAGTVVNTDTVKNQ
TQGGSIYGITTAISDGITFDKGRVQQSNFHDYRVPRMSDSPLEIEVEIIQSDAPPAGVGE
PSTPVYAPALCNAIFAACGKRIRQLPIGDQLKA
>A0A2S9YSW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Enhygromyxa salina|TrEMBL
MKLTIEVNGDRHDVDVDPETPLLWVLRDELRLTGTKYGCGVAQCGACTVHVDGRPRRACV
TPVRSVVDKRVTTIEGVSGPTADAVRNAWVSIDVPQCGYCQSGQIMTAVALLTKLRRPSD
DDIDHAMSGNICRCATYLRIRRAIHQAAGDAK
>G9AEK5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium fredii (strain HH103)|TrEMBL
MAIVTINGVEHSVDAEADMPLLWVIRDLVGLTGTKFGCGMAQCGACTVYVDGSPVRSCQT
FIGDIEGAKVTTIEGLKGKVAEAVQAVWADLDVPQCGYCQSGQIMSATDLLANNPKPSDE
DIDTAMSGNLCRCATYHRIRAGIHEAAKRLEG
>A0A5P9PC02|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. YIM 10|TrEMBL
MPNYTFSVNGKTVTVDAPADLPLLWALRDKLGVKGPKYGCGIDVCKACTSHLDGEAINPC
VTPLAEVEGREVTTIEGLADGDKLHPVQEAWLEMDVAQCGYCQPGQIMATVALLKKNPDP
TDAEIDAIENVCRCGTYFRIREAIKRAAAK
>A0A7W9TXE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bannensis|TrEMBL
MRDPKLTHDGARAAISRRQFLAGMSALTLAVGFRGGLAVAATLDPAKNATQFSFEPNAFI
RVDASGAVTVIAEYLEMGQGTFTGLATLAADELDVPLDKVSVEAAPADVKKYANPMFAAF
GWTLQATGGSTAMAGAWKQMREAAAAARVMLVSAAAKQWKVDPATLHVEDGVIVHAASGR
RAGYGQFVAAAAREPVPAKVALKQPGEFRLIGKRDTKRVDIPAKVNGSAIYTQDMKLPGM
LVAVIAHPPRLGGTVRHVDASKAKAIRGVVAVVQIPGDDEVQGGVAVLASNTWIARQGRD
ALNITWDDSRAFALSSTDIFSQFRTLADQPGNVAEQRGKVLTAAPEGGKYIEAVYEQPYL
AHAPMEPMNCLIQLQGDRCEIWNGEQWHTADQSMAAKELGLKPEQVTIHQLYAGGSFGRR
ANPHSDFVREAARVARAAHAQGVTAPVKLVWMREDDMRAGYYRPLTVHKVRVAVDKAGAL
VSWNHDVVGQSFMQLPKPDSIDPVLVEGAADIPYAIPNFRVAQHKAKLPVQTQWMRSVGH
THSAFVGETMMDEAARAAGKDPYAFRHALLGNMPRHRGVLELVAQKAAWSTPLKPGPQGT
RRGRGIALQLAFGTYVAQVAEVTVQADGAFTVDRVVCAVDCGMVVNPDIVATQVEGGIGF
GLTFLRTAITFDKGHVRQGNFNDYPVLRMSGMPVVEVHIVPSKEAPTGIGEPGVPPAAPA
VANALAAATGATIRSLPLGDALRPA
>A0A5P9PRF6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis sp. YIM 10|TrEMBL
MTLSRRGFLTAAGTTALLVAIPVPMAGAAEKGADEFEPNVFVRIGADGRIEVTVPRPDTG
QGVRTVALLLVAEELSVVPQQIEVRQAPGDTARYGSQMIAGSQSAHLMMEPLRTAGATAR
CLLVEAAARRWQVPVARCRARDGYVEHDQHGRLAYAELVAEAAAIDPATVPVTLIPQAEW
RFLGKEATRIDAADIVTGRARFGIDVREPGTQFAVVRRADWLGATVATVDDTAARAVPGV
LEVIRLDPAEGTQGGVAVIADSTAAALAGRAALTVGWTGGTPQADSRAWLADLASAVPAP
PTPPGPVGLDLTYRLPLLAHAPMEPLNATAHLPGDGTLTIHAPTQDPGGLRDQLAQILKL
DRAAVTVHATLSGGAFGRRFELDFVLEAVACSRVTGKPVKLLWTRDDDTRHDSYRPMSVH
RLTAVLARDGVPRWRSHEVATWPLTTAPFFGKPELVLLSGDHFPYRVPGKPSVVLRPSPL
RTGFWRSVYAGQFVFAEECFLSAAGLRAGLDQIELRRRLLPEDSRVRRVLDAAAAKAPPP
AGVSRGVACHLDYGSAIAVLADVRDHDGTPVVSRVTAAVDVGIALHPSGVRAQVEGGILD
AVSTVFGAQITVREGRVVQSSFRDYAWARIDRAPEIDVVIVDSGEAVGGLGELAYPPASA
AMASAVAALTGVPVAGMPVTAETG
>A0A1A7C965|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium psychrotolerans|TrEMBL
MITLNINGSDMQVDADPSTPVLWALRDNLNLTGTKFGCGAALCGACTVHLDGQPIRSCIT
PISSVAGQKITTIEAMENDQVGKAVQAAWVRHDVPQCGYCQSGQVMSATALLRTNHSPSD
ADIDSAMSGNICRCGTYQRIRAAIKDAATTLAQA
>A0A1A7C3G7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium psychrotolerans|TrEMBL
MNAPDKMIASASRRNWLKAAGALAGFTLVAGPSGLVMAADAVKYGGDNMPGGVVDDALVF
LAIGSDGIVTIMSHRSEMGQGIRTSLPMVAADELGADWAKVKVQQAAADEARYGSQDTDG
SRSMRHSFRAMRHVGATARLMLETAAAARWSVAVTEVKAAGHQVVHAASGRTLGFGELAA
EAAKLPVPPRASISLKRADELRYIGQDNKRGIDLHDIVTGNTHFGIDTRLEGMSYAVIAR
PPVFGGKLKSVDKTAALKVPGVLRIVELAGSPPPAMFNPLGGVAVIASNTWAAIKGREAL
VLEWEDGANGAYDSKAFRATLEAAVRQSAKPARDQGKTVETLAAAPAKRKMSAEYYLPHL
AHATMEPPAATVRVINGKAEVWACVQAPQATRSNVAKALGLPFDDVTVHVTLLGGGFGRK
SKPDFAVEAALLSQAMDGKPVKLTWTRDDDLQHDYLHTVSVERLEASLDAKGMPTAWLHR
TAAPTIASTFAAGANKQAPFELGMSAINVPFAIPNVRVEVPEVPAHTRIGWFRSVSNIPH
AFAIQSFAAELAHAAKKDHRDYLLELLGPARRIDPKDLSDGWNYGEDPAKYPVDIGRMRH
VIELATAKAGWGRKLPKGRGLGLAVSYSFVTYVAAVIEVEINAAGEVLIPRVDIAMDCGP
QINPDRVRSQIEGACIMGLSLAMSGEISFKNGRVEQSNFHDYAVLRAADAPRVIHTHLVP
GTLDMELGGVGEPATPPIAPALCNAIFAATGKRIRALPVGMQLAKKA
>A0A1A7C5Z1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium psychrotolerans|TrEMBL
MHHVIINGVPFAADVDADTPLLWVLRDEAKLSGTKFGCGIGLCGACTVHVNGRAVRSCIT
PVSAVAGSAVTTIEGLSPDGKHPLQQAWIATQAPQCGYCQSGQIMQAATLLRDYPQPTDA
NIDAVMSGNLCRCMAYVRIRKAIKLAAGMRETPHA
>A0A5E7MA98|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKSVGATSALVLVASWGWQDAFAAGEQKKFGADGMPHGWIDD
PKVYISIADDGMVTVVCNRSEMGQGVRTSLTMVVADELEADWAMMKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAQQWKVPVSECRAQLHKVIHQPTGRELGYG
ALAAAAGALAVPARDSLRLKQPSEFRYIGKEGSKAIDGDDIVNGRAVYGADVHFEGMLYA
TIARPAVYGGKVKSFDASAAMKVPGVIKVIQIEDRPLPLEFQPLGGVAVVASNTWAAIKG
RDALKIEWDDGPHASYDSIAYRKELEAASLKPGKVVRNTGNIEEAMGSADSTLEASYYLP
HLTQAPMEPMVAIARFKDGLCEAWAPSQAPQVTRERIGERLGIPFEKVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLSKDGLPSAWL
HRTVAPSITALFAPEMNHEAAFELGMGFTNMAYAIPNVRLENPEAAVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGREMPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRDLPVRYQLQGWQKAQA
>A0A5E6XZ14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSPLPNDFALSNLSRRGFLKGVGATSALVLAASWGWQDAFAAEAEKKFGADGMPNGWIDD
PKVYVSIAADGSVTVVCNRSEMGQGVRTSLSMVVADELDADWALVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVGECHAQLHKIIHKPTGRELGYG
ALAAAASALAVPARDSLRLKEQSEFRYIGKEGTKAIDGADIVNGRALYGADVHVDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVIKVIQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNTSYDSIAYRKELEASSLKPGKVVRNTGDIDAAMSGADSKLEASYYLP
HLAQAPMEPMVAIARFKDGVCEAWAPSQAPQVTRKRIGERLGIPFDNVTIHVTLLGGGFG
RKSKPDFIIEAAILAREFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLGKDGLPSGWL
HRTVAPSISALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAIHTRVGWFRSVSNI
PHGFAIQSFVDELAHQAKQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E6QMZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MKSSNPISRRGFLKGSALLGSGLVVAFVLPGAHRFAMGAENQGEVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGLAAFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAARRFNVAPSTLRTEPGVVIAGDRRATYGELADDAGKL
PVADPAALTLKEARDWRLIGKPTKRLDTPEKITGRAKFGIDVQFDGLMTAMVARSPVLGG
SVKSFEGAEALSIPGVHKVVQVPSGVAVIADHYWAAKLARDALKIDWDLGANAGLDSQVL
LEDFRKLAGTAGASASKAGDVEQALSNAAKSIDVEYSVPYLAHAPMEPLNCTVKITQDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTQFLGGGFGRRANPTSDFVAEAVEVAKAAG
MPVKTVWAREDDIRGGYYRSAFLHQARVGLDADGSPIAWKHVLVGQSIMAGTLLEASMVK
EGVDKTSVEGVADSPYLAKLANHQVDLHSPQTGITVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVDYRRTLLREHPRHLGVLDLAVEKAAWQAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLGIRVHRVVCAVDCGIAVNPLSIAAQMESAIAFGLGFTLHSKLTFKDGQVQQSNY
HDYQVLRLNEMPRVEVHIVASSAKPGGVGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E6SVF6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSINALSRRGFLKGSAMLGGGLVVAFAMPGAHRFAMGAENQGNVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWTKIRVEHAPASAADYGLPGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIHTESGVVMAGEHRATYGELADDAGQL
PRPDPASIKLKDAKDWKLIGKPTQRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPTFGG
SVKSFEGAEALAIPGVHKVVQVPTGIAVIADHFWAAKLGRDALKIEWNPGPNAGLDSQAL
LENFRKLATTPGLNAGQAGDTQAALAKAAKKIDVEYSVPYLAHAPMEPLNCTVSITKDKC
EIWTGTQFQTLDQMVAGKITGLKPEQVVIHTEFLGGGFGRRANPTSDFVSEAVYVAKAAG
APVKTVWAREDDIRGGYYRSAFLHHARIGLGADGMPLAWKHVMVGQSIMAGTSLEATMVK
DGIDKTSVEGVVDSPYIEGLANHQIELHSPTTGISVLWLRSVGHTHTAFVMESLIDELAT
AAGKDPVEYRRTLLKDHPRHLGVLNLAVQKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLSFALHSKLTLKDGQMVQSNY
HDYRVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPMAPAVANAVFALTGQRLRELPLQLA
GV
>A0A5E6T7D2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNLINELLDTPVNLSRRRFLASTAVGALVIGFGLPLGSGRVQAATTAERGTQVPAFLEIR
PDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAYVVMENGMRITGG
SMSVRMSYPTMRRLGALARAMLLQAGAEQLAVPVSELTTQPGRVVHAASGRSLGYGELAS
RALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKVDNMLHAAVQHA
PRLGMTVGSLRNQPQVEAMKGVHSVHVLPGAVAVVAERWWHAKRAAEAIQVDWQEAAADS
TLRVMPADFSSDKHRDFLAAQQGPARDDENEGDVAAALKGAKTQLEATYHNQYLNHAQLE
PPSALARFNPDGTLEIWLPNQAPDMFRADIAKRTGLDPANITLHSPLLGGFFGRHFLYDS
ANPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPLAVVKFRAALDDKGLPIAIEAVSAT
EGPTEALAGKQGDKIDPTAVEGLSGKSYAIPNKRIAQIYVKGAPMLGYWRSVGNSLNDFF
YESFLDELADKGGHDPYELRLHLLRDNPRLTTLLQAAGELSGGWKRGPFTAEDGTRRARG
VAMASPFGSHTAAIAEVSIEGGKVKVHDIWQAIDPGSIVNPAIVEAQVNGAVALGLSQTL
LEEAVYVDGKPRARNYDLYPILAPAQMARVHVRVVESGEKMGGIGEPPLPAVAPAVANAV
AQLTGQRIRSLPMSRHTFS
>A0A5E6ZSZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATSALVVAASWGWQDAFAAEKEKKFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELDADWALVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVGECHAQLHKVIHKPSGRELGYG
ALAVAAGALAVPPRDSLRLKDPSEFRYIGKEGTKAIDGADIVNGRAIYGADVHFDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVIKVIQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
RDALKIEWDDGPNASYDSIAYRKEIEAASLKPGKVVRNTGNIDEAMSSASSTVEASYYLP
HLAQAPMEPMVAIARFKDGVCEAWAPSQAPQVTRERIGERLGIAFDNVTFHVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLGKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAIHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAKQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGVVPLGGVGEPGVPPIAPALCNAIFAATGKRIRDLPVRFQLQGWQKAEA
>A0A5E6UP50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNVRIDPSLQASVLDLHEPINVSRRRFLTGTAVGALVLGFGLPLGATRVQAAVAAATAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPSTFLVEAAPPGEAYV
VLENGMRITGGSMSVRMSYPVMRRLGALARTMLLQAGAQQLGVPVSELSTEPGKVVHAKS
GRSLAYGELAERAMDLPVPDPASVKLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKV
DDMLHAAVQHAPRLGMTVGNLRNEDQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTADSKVRPMPADFSSDAWFKRLAEDKGPAKDDENQGDVAAILKETKTRIDATY
HNQYLNHGQLEPPSALARFNPDGTLEVWLPNQAPDMFRADIAKRTGLDPSRITLHSPLLG
GFFGRHFLYDSASPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRAALDNDG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKTYAIPNKRIAQIYVKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFDLRLHLLRDNKRLTTLLQAVGELSGGWKRGPF
TAEDGSKRARGVAMASPFGTETAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEEAVWVDGKPRARNYDLYPILPPARMARVHLRVVESGEKMGGIGEPPL
PAVAPAVANAVARLTGQRVRSLPMSRHTFT
>A0A379IHI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPSNFVLNNLSRRGFLKGIGATAALVVAASWGVPGAFAEEVKKYGAEAMPNGVIDDP
KVYVSIAADGSVTVICNRSEMGQGVRTSLAMVVADELEADWAQVKVEQAPGDEVRFGNQD
TDGSRSMRHWYEPMRRCGAAVRSMLEQAAAEQWKVPLGECRAQLHKVIHQPSGRELGYGA
LAAAAGALAVPARDSLRLKQPSEFRYIGKEATKAIDGADIVNGRALYGADVHFDGMLFAT
IARPKVYGGKVKSFDASAALKVPGAIKVLSIESRPLPSEFQPLGGVAVVASNTWAAIKGR
EALQIVWEDGANAGYNSIDYRKTLEAAALQPGKVVRNTGSIDQALSDADSTFDAAYYLPH
LAQSPMEPMVAVARYQDGQCEAWAPSQAPQVTRERVAERLGLPFDNVTIHVTLLGGGFGR
KSKPDFIIEAAVLAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGLNKDGMPSGWLH
RTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAAHTRVGWYRSVSNIP
HGFAIQSFVDELAHKAGQDPLKYQLKLLGPDRQIDPRTLSEEWNYGESPERYPIDTARMR
GVLETAAKAAGWGRALPKGRGLGLAVHYSFVTYVAAVIEVEVKGDGTLIVHKADIAVDCG
PQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPREIVIHLV
TPPGEVPLGGVGEPGVPPIAPALCNAIFAATGKRIRSLPVRYQLQGWQQEAKA
>A0A5E7EZW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSAMLGGGLVVAFAVPGGHRFAMAAENEGKVFAPNAFLRIGADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSTIRVEHSPASAADYGMPAFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFDVAPSTIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGATV
KSFEGAQALAIPGVHKVLQVPTGVAVIAQHYWAAKLGRDALKIDWDLGPHADLSSEKLLE
SFRKLATTPGTSASQAGDAKGNFTNAAKKIDVEYSVPYLAHAPMEPLNCTVKISAQKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAGLP
VKTVWSREDDIRGGYYRSMFLHQARIGLGADGLPLSWQHVLVGQSIMTGTLLEATMVKNG
IDPTSVEGVSDSPYVKGLAHHQVDLHSPQTGINVLWLRSVGHSHTAFVMESLIDEMATAA
GKDPVEYRRTLLKEHPRHLGVLNLAVEKANWTAPLPDGHALGVAVHESFGSYVAQVAQVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLKDGAVVQSNYHD
YQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVYALTGQRLRELPLQLSGV
>A0A5E7H8C9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSLLEDSGAELPRRVFLKQAVTVASGLAIALYLPSGMAATDPKAPAPASEFEPNAWVRVL
PDGTVKLVVHKHDSGTGTHTALAACVAEELDVNPMTVQVITPEDPFFETYIHPIWKVFST
GGSTSVSLEYDRLRMAGATARALLITAAAKQWKVSADSCSTEEGRVVHPSSKRSLGYGEL
VGVAAHLPAPDKVTLKDPSQFKYIGKLRHKRDAAAKVCGQFIYSIDVQLPGMLVAVIQRA
PVVGAKVVSVGSAAALRVPGVRKVIAIPGRPDVLGGNLEGVAVLADTYWAAQEGRKLLEI
QWSDSVLAGFDSDQLFSAQAKAIGDPQAQTVNAMTQGDVAGQWAGAAQLLEADYTMPYKV
QNPLEPICITAHVKDKAITYWGGVQVPSSALEAARTVCGIDQANVTIHELVSGGSFGARE
AKYWLFEVAYLAQKTAVPVKLLNSREDEMHALFYHPATLNRIKGALDAQGKLTALQLHAV
SPASPEQWEPGYFQRPDHMDYSTTEAITAWDFTYRPPHLQLNWVKHESNVPSGWYRSVSF
IPNVFAVESFMDELAHAAGADPLAFRLANMQERPRHVAVLKQAAERAGWGQPLPPGTALG
IATNQGYTSFIAVVARVTTVDGKARVEKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHAL
FDKLDIKQGRVVQSNFHDYRVARMSDMPATDIVVLDGEPSKPGGVGELGSPSVVPAIANA
LFALTGVRQRSTPLSLG
>A0A5E7CVW4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLNINDQEMRVDVAADTPLLWVLRDTLQLTGTRFGCGMALCGACTVHMDGQPVRACST
PVSAAAGAKILTIEGVGQGTTGKAVQNAWQHLDVVQCGYCQSGQIMSAVALLKNNPKPTD
ADIDQAMGGNVCRCATYVRIRAAIHDAAKSLA
>A0A5E7F2T6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGATATGALVLAASWGWQDAFAEDKPKQFGADGMPNGWIDD
PKVYVSIASDGTVTVVCNRSEMGQGVRTSLTMVVADELDADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHKPSGRELGYG
ELAAAASALAVPARDSLRLKQPSEFRYIGKEGSKAIDGDDIVKGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSVDDSAALKVPGVIKVMQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSSAASTLEASYYLP
HLAQAPMEPMVAIARFNNGVCEAWAPSQAPQVTRERIAERLGLPFDNVTVNVTLLGGGFG
RKSKPDFVIEAAILAKEFPGKAVRVQWTREDDVHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEARVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGVDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RAVLETAAKSAGWGRQLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAQA
>A0A5E7LXW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLNDIFFQELPCSLQHLLERDQADGAFTLPRRSFLKIVGIGGLALGAFPHLALAQEAAGG
DAALLKPSQQPSAFVQIDSSGQVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
NNNTAYQDPVFGMHLTGGSNSIKNSYTQYRELGARARAMLLAAAAARWNVEVTRLSTQAG
MVLGPAGLKASYGELAEAAMALPVPDKVTLKDPRDFRIIGQATTRIDAKAKSSGQQDFGI
DMHLPGQLTAVVARPPVFGAKIASLDDSAARAIKGVKAALRVPLDGGAEGVAVIADGYWQ
AKLGRDALKLQWDLATVEKVDSEQQLIQYRALAGQPGLVHFDADMAPLATAKHQLEAEFV
FPYLAHAPMEPLNCTVQISDKGAQLWVGTQFPGGDSAAAAKVLNLKPEHIQINVQTAGGG
FGRRGVPTSDFIVQACEVAKAARSVGLNVPIRTLWSREDDIKGGYYRPMHLHRARIGFDD
SGTVVAWDHVLIGQSILTDTMFGGQIKNGIDPTATEGMRDPYPLPMRLTVHHPKLNVPVL
WWRSVGSTHTAFVMETLLDEIARTTKQDPVAYRMKLFGEQSPRHREALQLAVDKSGYGIR
QLPAGHAWGVAVHECFSSVVAYVVEASVQNGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
ALMGLSMCLPGNAITLKDGVVQQSNFADFSVPRITDMPEFAVHVVPSAEPPTGMGEPGLP
ALAPAFANAIASLTGKPIRELPFNLA
>A0A017HIF5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubellimicrobium mesophilum DSM 19309|TrEMBL
MTTRLTVNGAVVDAESDPDTPLLYVLRDELGLHGAKYGCGLGQCGACTVMVDGTAVLSCL
MPLLTVEGRKVLTVEGLGTADAPGPMQAAFIAEQAAQCGYCIPGMMMRAQATLTANPGAS
EQEIREALEFNLCRCGTHIRILRAILRAQGEMQQAAASRPVGEDVL
>A0A7W8M9N8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Quisquiliibacterium transsilvanicum|TrEMBL
MPTRRRFILGTLAATGALAIGWGAMPPRQRLVTREPLPAAAGQVPLNGWVKIDRDDTVTV
MMAKSEMGQGIHTALAAILAEELDADWPRVRTEMSPIDPIYNNLAAVVDGLPLHPDEDGT
LKRFAGWMTAKAMREFGVMMTGGSSSTKDLWLPMRQAGASARAMLVAAAAQQWQVDAAGI
TVAAGLVAHAASGRQARFGELAEAAGRQPLPADPPLKDPKRFTLLGRPLRRTDAADKIAG
RTGFGSDVLLPGMLYAAVQMCPTLGGSVRRLDAAKAHAMPGVRKVVSFPALNGGTGGVAA
IADTPWQAMQAAPAVEVEWDHGAMAGFSSAAAIEQIAATLDREDGFSYYSTGDVDAALAT
AAKVVEAEYRAPWLAHTPMEPVNCTVQFRDGRATVWVPTQVPGLARMAAARALGIDTEAV
EVKVQFLGGGFGRRLEVDFVAQAAAIALQADGAPVQVLWTREQDIRHDVYRPACVSRFRA
GLDAQGGLAAWRNTSAGQAIVPQALGRLFGLPGAGPDKTAAEGAFDQPYEFPNARIAHET
VQLPLQVGFWRAVGHSHHAFFKEGFMDEVAASAGRDPVAFREALLQRHPRHLAVLQRAAA
MADWGSPIAAAADGRRRGKGVALHQSFGAIVAQVAQVSVGDDGAIRVEQVWCAIDCGFAV
NPNVIRQQVESAIVYGLSAALHGEVTIEDGRVVQSNFHDYPALRIGECPVIETAIIDSIE
HPEGVGEPGLPPIAPAVANAVFAATGQRLRALPLKLA
>A0A0P1F9Y8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MASVGKILRRTFLIGSAAIVGGVAFGAYYVSRPAANPLKPAKGETALSPFVLIDQQGVTL
FAPRAEMGQGVRTTWAALIAEELDVELDQIRVLHGPAAAAYYNSALVGEGLPNKGYDISD
FQHNLGEALGVLGRTLSLQVTGGSTSMKDGFERMREAGATARETLKQAAADRLGVDRAQL
KTENGAVVAPDGTRIPYTELAEAAGQIEPPEVELRDPSNWRLLGRSLPRVDVVGKSTGTA
EFGIDVRPEGLKFASVRINPKLGGEMKGFDASAAEQMPGVEKVVDLGNGVAVIASNTWLA
IQAVEAIDVDWGDAPYPPETDAVFAEIAKSFDASPNSTMRDDGDVDTLPDGATEITVEYT
VPYLAHSTMEPMNATALFTGSALELWCGNQAPTLVQIRAANTANLDKEAVQIHTTYLGGG
FGRRGELDFGEIATKVAMAMPGVPVQTTWSREEDMRHDYYRPGAMARMRGAVKDGQAVLI
DGKVAAQSCTQQAVQRYTGLPAGGPDKVLVEGFFNQPYAVPNYRMSGHIADLDIPVGFWR
SVGNSHNGFFHETFMDEVAHAAGRDPLEFRLELAKADHAPSAGCLQAVKEMSGWTGETPD
GVGRGVAMTYSFGTPVAQVIEVVDEDGTIRIAKAWIACDVGLALDPGTVESQMFGGMIYG
LSAAVMGEITFSDGEVEQYNFPDYDALRMHNAPVTEVKILETNHHMGGAGEPGTPPSMPA
LGNALFDLTGERARTLPLINQFNLLV
>A0A7X5UQU0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharomonospora amisosensis|TrEMBL
MAGEHPTPDASPQGMRRRRFLGYLLAAPTLAVAAQVGAGAANPGTASAVVPSLPGPADIL
DLGDALTLAAAPTANLITITIERDGTATFAVPRAEVGQGITTTVAMLIAEELDLPLDKVN
VPLADARPELVFNQLTGGSNSVRSLYDPVRTAAAIARARLLATAAARWNVDVGALSVRAG
VVIGPNGQQADYGSLTEAAASTSTEQVSAEPKPPGQFTLVGTPQSRIDALEAVTGKKQFT
MDLRVPGAKPTMVCRPPTINGTVRAVHNAAEVEAMPGITDVTVISTGVAVRGETFGQCID
AVRALRVDWGPGTVDGESDETVLSKLKAATLPAAVPPLLTKSLDAEFVFDFSSNSALETN
CAIADVRADRAEIWSGLKSPIVAQEQIAARLGLPVSAVKVHVVTGGGSFGRKLFSDAALE
AAEISRKIGKPVKLMWHRADDSRHGRAHPMSVSRIRANYSAGNVVSFEHRHTSVETDFGH
GLGEILTSVAARLPVGDVSFSQTVFLLSQSNPYHLGATTQTLNEVPLKFHTGSMRNVYSP
NVVCARELVIDALAEKLGKDPVAFRRELLKEDRFRAVLDKLVEVGEWGRPMPEGTAQGVG
FHLEYKSVSAVLVEIDCRPETVNREIRDAVTGPRVTKAVGVVDAGLPINPRGLEAQMIGC
INDGIALALTSSLHVEDGLPLEASWDNYFYTRQWNTPPEMRVVVMPPTTGVPGGAGELGV
ASSLAAVASAYGRATATMPTRFPINHATLSFEPKPKVPPVPASPVDGLKYAQ
>A0A0P1E9S6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MTINTSRRGFLKGAAAAGAVLLVGARPDGALAAASSETAQFNPFVKIDADGTVTAIVKHF
EKGQGPATGLPTLIAEEIGLTMDQIEYEFAPSNPQVYNNLLFGPFQGTGGSTAMANSWMQ
YRQAGAAAREMLINAAAQIWGVDASGITIEEGIVKAGDNSAPIAEFVAAASQLEAPAEPR
LKDPSEFRLIGNETVRRKDSAIKGNGQAMYAMDVHLPNQMVAMIKRPESKGGIANSFDDS
ASKEVKGYISAAVLPNQAGVAVYAENTWAAIQARDALEVDWDMSGSETRDSDQIKAEIMA
ALDAEATYNVNKADVAAVSAAIDGADTVVEKTFYFPLLAHAPMEPLNCTIEQTAEGDIVL
HDGAQMPTGPHMAYQQIFQLPTEKIHIKTMLAGGSFGRRATPDADYQVEAALAFVVTDRS
RPVKLVWTREDDIRSGYYRPAFGHRVRVGLDADGKIVGWQHQVAGQSVIKGTPFEAVAVH
DGVDHSSVEGIADSPYDIPGMALGLTDTPKATTVLWWRSVGHTHTGYVMETMMDTVAEAA
GRDPVEFRLSHLSDTNNADQQRKAEVLKLAVEKAGWGNAPAGRAQGIAVHKSFGSYAAQV
VEVSGDPENGIKIEKVTCAVDCGIAVNPDVVRAQMEGGIGYGIGHVMRDQITLTQGAVDQ
YNFPDYEPLRIGDVAEIDVHIVPSAEAPTGVGEPGTPPSAPALANAIQALSGVKVTTLPM
VENGVSFV
>A0A0P1EII6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MATALKINGKQHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGIGTPDAMAAIQQAWVDHQVAQCGYCQSGQIMQAAALLAENPAPSD
TDIDDAMQGNLCRCGTYPRIRAAIHDAASKLKEA
>A0A7X5UQV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharomonospora amisosensis|TrEMBL
MPQHTFTVNGEQVTVDAEDNVRLLWVLRDLLGITGPKYGCGINVCKACTSHINGKAFNPC
AVPVSKIKPSDEITTIEGVADPDTGELHPMQQAWLERDVSQCGYCQPGQIMAAIAKVRKV
KAEGREISDADLDEIRNICRCGTYSRIREAIKSAAEKM
>B9B0A7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD1|TrEMBL
MVTLNINGETRTVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRRITTIEAVGATPAGQKVQQAWRALDVVQCGYCQSGQVMAAAALIASNPKPSD
ADIDAAMAGNICRCGTYHRIRAAIKQAAQEA
>A0A484P7D1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPET
PAGWRALAFNGHVDLGTGIRTSLAQIVAEELEVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAAHWQVPATALRARAGRIVFADGADSRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGALTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGQSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREI
PPAPDLGDLEAALRANRAEPRHLRGDGNAAHALATTPDARRLRRSYVWPYQMHASIGPSC
AVADHADGRLTVWSGTQNPHMLRVDLNRLLDLGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLVDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGSVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGGDGLLRG
RGVAYARYIHSKFPGFGAAWAAWVVDLRVDPASGHITLDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPDIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRKALLARKQPGMPRADAPPLRHATRVD
>A0A0H5CJQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alloactinosynnema sp. L-07|TrEMBL
MPTYRFTVNGEKVSVDAPADTSLLWVLRERLGVTGPKYGCGVGACRACTSHLDGAEIQPC
VVPVSQCQGRKVTTIEGLADGDTLHPVQQAWLDEDVAQCGFCQPGQIMAAVALLDRTDEP
TDADIDAIENVCRCGTYCRIRSAIKRAAAST
>A0A840WJ45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubricella aquisinus|TrEMBL
MTRLSVNGTQHNVDVEADMPLLWVLRDELNITGPKYGCGIGQCGACTVHLDGYAVRSCQL
AIGDLDGAQITTIEGLSAGGTLHAVQEAWISHQVAQCGYCQAGQIMQAVTLLADIPDPTD
QDIDDYMSGNLCRCGTYPRIRAAIRTAAQTLQGT
>A0A7Y9WAA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MSQGLLDAGNGAQPSGTKAGRVSRRTFLKFGVTVGAAAGGGLLLGFSLPAASQDQKAGKS
VIGGDGVETPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVPLDS
VTVDHAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRRAGAAARVVLIQAAAQQWQVDPA
SCHAQAGQVIHAASQRSLGYGQLADAAAKLPAPQNVPLKNPKDFKLIGTSPKRLDSPEKV
DGTALFGLDVRVPGMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQIVKIDNAVAVIGDH
TWAAKRGVQALDIKWNEGAGAAISMQQIVGDLATASERNGAVARKDGDVGKGFSDAKTRV
DAVYQQPFLAHATMEPINCTVHVRPDGCDVWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LIGGGFGRRLEFDMVTQAVKVAKQVSSPVKVTWTREEDIQHDMYRPYYYDKISAGLDANG
KPIAWQHRIVGSSVIARFAPPAFKNGIDPDAVEVAADLPYDLPNQLIDYVRQEPHAVPTA
FWRGVGPTRGTFVVESFIDELAAQAKVDPVKYRQDLLGKTPRALNVLNVATQSAGWGSAL
PKGQGRGVSVMHAFGSFFAIVVDVAVDQGEVAVKRVVCAVDCGMVVNPNTIEAQVQGGII
FGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIEVHIVKSGEAPGGIGEPGTAALA
PALTNAIYAATGKRLRHLPVGSQLQTA
>A0A7Z0BAA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDRKITTIEAVGSTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLLTSNPNPSD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGA
>A0A0R0LTH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ferrovum sp. JA12|TrEMBL
MTTELKLNGKLFQLDTDPNTPLLWVIRDVVGLTGTKFSCGAGLCGACTVHVNGEATRSCI
TPLSDAAGKEVTTIEGLSVEGDHPLQLAWQELNVSQCGYCQSGQIMNAASLLKKNPHPSS
SDIDQAMTGNLCRCGTYNRIRAAIELAAKKG
>A0A5E7JV77|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSVLTINGREYTVDVDPSTPILWTLRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGRKITTIEAATNGSDPVGAAVHEAWVKHDVAQCGYCQSGQIMSATAFLKVQPKG
KQPTAAEIDSAMAGNICRCGTYARIRAAVADAAKVLA
>A0A031GR11|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MITLNINGRDTQVDADPSTPILWALRDNLNMTGTKFGCGAALCGACTVHLDGQPIRSCIT
PISSVGAQKITTIEAMENDQVGKAVQAAWVRHDVPQCGYCQSGQVMSATALLRTNKAPSD
ADIDGAMSGNICRCGTYQRIRAAIKDAAKTLA
>A0A484VEL4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MEPAAPLLFVLRNDLALNGPKYGCGLGECGACTVLVDGVAARACVMPVRGVIGREVTTLE
GLGDAACPGPTQQAFIECQAAQCGYCLNGMIMMIEALLRRQPAPDDARIRQELRHNLCRC
GTHVEILQAARRAVALHAQARETACAKRSGQ
>A0A0S4TTJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MITLDINGKPTHVDAASDTPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCST
PLSAAAGKKITTIEGVDRARVGKAVQAAWRRLDVVQCGYCQSGQIMSAVALLEGNRQPTD
ADIDAAMAGNICRCATYVRIRAAIHDAAKSLA
>A0A0S4X7S3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MTADATAPRRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQPGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVRVESAPIERIYGNVVSVVDSAL
PLHPDDAGKAWARALHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
RAWNVQAAQVSVHDGRLIGPGGRQAGFGEVAAHARDIAPPASVTLKPASQYRLVGQPAPR
SDAAGKTDGSARFAIDVRPPGLLYAAVAMCPVFGGRLKAFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLEPVWDSGPHAALDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVGGATVVEAEYSVPYLAHAAMEPINCTAQVTRDHVQLWAPTQVATLAQLV
AARAAGVRREQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIERGRVTALASRSAGQSILAGELGRLFGAPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEVAAAAGLDPLAMRRDLLEAHP
RERTVLDTAARAAGWGQPLAQAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPGIVARQVESAVIFGLGAALHGQIQVKDGQVVQSNYSDYPVLGMADTPV
IETHLVPSAAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A2E2KUH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium|TrEMBL
MTISLKVNGTSHRVDLPPDMPLLWVLRDQLGLTGTKFGCGVSACGACTVHIDGEPVRSCQ
VSLEDVWGEVSTIESLGTPDRLSILQQAWVDHQVAQCGYCQSGQIMQAAALLAANPAPTD
AEIDDAMAGNLCRCGTYPRIRAAIHAAATRMSEA
>A0A1C3HDE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia marcescens|TrEMBL
MIHLTVNDQPLTFEGDPHMPLLWFLRDEAGLTGTKFGCGIAMCGACTVHLDGVPVRSCMT
PVSAAVGKKITTIEAVGATPEGKAVQEAWLDLDVVQCGYCQSGQIMSASALLAQSKNPSD
ADIDAAMGGNVCRCATYVRIRAAIHQAAKALG
>A0A291FY57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter piscinae|TrEMBL
MSTTLRINGTSHQVDLPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGVGTPDAMAAVQKAWVANQVAQCGYCQSGQIMQAASLLAENPSPSD
AEIDEAMQGNLCRCGSYPRIRAAIHDAASMMKEA
>A0A653XP97|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides sp. AX2bis|TrEMBL
MTSTISSNLDEQDEGAGVTGFRRRRFLGYVLGGSTLIAAAELSFAGSATADGIPSAPQIP
EVYDLEDAQTDAALPTSQLIQIVINTDGTASFELPRSENGQGVTTSTAMIIAEELDIALK
KVKVTLAPARPELFLNQLTGGSNTTFSTYTPIRVAAAIARRALLDAAANRFETDAERLEV
IAGVITNTATGETLTFGDLAEEAAGLFDREVEVELKDDAEMTIVGTPRGRDDARLAVTGA
KDFAMDLDIAGALPTMICRAPTLNGTPRVLQNRSAILAMPGVAGVAQVSTGIAVRARTFG
QCIDAIRAMKVSWNQGSVEGESDETILAELRRAELPFTPVSQVPDLPLLGNKTHELSFEF
MFRSSAALEPYAAVADVRADSAEVWAGLKSPILAQQDIAKMLGLSQEQVTVNVVTGGGSF
GHKLFSNHALEAAECSRALGNVPVRLMWHRADEPRQGRLHPMVTSRIRAVTAPALIGTGR
KVFAFEQRNTSVVTDFSHGFGEVITSTVADLPAGLGELSLSQTIFVLTQELGYDFGAVTQ
LLNEVDSRFNTGSMRNIYSPDTRVAAELMVDVLAKDADKDPLEYRLEFLRNEETKRALEK
VAEEGNWGRRMPAGTAQGIAIHKEYKGVTACLVEIDCRPGTVNRDIREAVTGPRVTKGVF
AIDAGKVINPRGLEAQMIGGFSDGIAMTLTASVHLKAGHFLEASWDNYFYTRQWNVPPAL
EVHILPSDKSTPGGAGEAGVAATAAATACAYVRATGTMPTRFPIAHDTSLSAFTPKSFVP
PVPPSPTNGLKLTR
>S5TTW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured bacterium esnapd4|TrEMBL
MTCDNEVPVPETRVPVRRRQFLTFLVAAPVLTVAVPATAEAVIPTLPQPAEILDLGEILI
LAGTPTAGALAVLSVGEDGVVTLELPRAEVGQGITTATAMLVAEELDLPLSRVRVELADA
RPELLFNQLTGGSNTIRSVYGPIRQAAAAARARLLAAAAERHGVGVDRLSTRDGAVVLPD
GRLIAYGLLTSAAAQLTGVFAAQPKPASEHRLVGTPQSRIDARAMVTGQFKYTLDHDVPG
ALPTVVRRPPTINGTVRSVDSSAAKAMPGVVAIGVVPTGVAVLAETFGQAMAARDALKVT
WNPGTIDALSDQDIRAKLRAATLPFVVPPLLTQHVDMEFDFAFVSHAPMETNSAIADVRD
DRAEIWAGLKSPVVARQTIASVVGLPESAVTVHVLQGGGSFGRRLFFDAAIEAAQISKAL
RRPVKLMWSRTDDMRHGRARAASHHRLRATFGLGNVLTFEHRVASVETDFRHGLGEILTA
TAASLPVAGNLSFAQTVFLTTCKVPYNFGVVTSLLNEVPLRMHTGSWRSVYSANTRGAEE
ILVDQLAKKMGKDPVAFRREHLKTAGQRAVLDKVASVGKWGRTMPKGFAQGVGFHDEYKS
CTACLVEIDARDPRNPRVVKAVIAVDVGRPINPRGLEAQLLGGLTDAISTTLRAGLHIEK
GLPLEGSYSQFHYARQKDAPLDVQIFVMPATGEPGGAGELGVPAAVGAIANAYARATGVV
PRSFPVIFPVDFEPFPR
>A0A1B8P481|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas elongata|TrEMBL
MGDERIGEAVQAAWRKLDVVQCGYCQSGQIMAAVALLSENADPSDDDIDSVMSGNICRCA
TYVRIRAAIHEAATSLA
>A0A485EZ48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MKRSYPDDLVIGNLSRRGFLKGVGATGVLLVAANWGWRDALAAEKKAFGADAMPHGWVDN
PKIYVSIDRDGTVGIVCNRSEMGQGVRTSLAMVVADELEADWSRVKVIQAPGDEARYGNQ
DTDGSRSMRHWFEPMRRCGAAARQMLEQAAANQWKVPLGECRAEQNKVLHAPSGRSLSFG
ELAEAAAGLEVPARDKLLLKKPEQFRYIGKDVARAIDGADIVNGRAGFGFDARFDDMLYA
VVARPPVYGGKLKRYDAAAALKVPGVVKVIEIEGRPIPSEFQPLGGVAVVAQNTWAAIKG
REALVVEWDAGVNGGYDSVAYRKQLEEAARKPGKVVRDSGDAAALFARGGDIVEAEYYLP
HLAQAPMEPPVSTAWYKDGACEVWAPTQAPQVTRERIAERLKLPFDKVTVNVTLLGGGFG
RKSKPDFVLEAAILAKAFPGRHLRVQWTREDDLHFSYFHTVSVERLQAVLGADGLPQAWL
HRSVAPSITALFGPDSKHQGAFELGMGLTNLPFAIPNVRLENPEAPAHTRVGWFRSVSNI
PHAFAIQSFVGELAAKAGQDPKDYLLKLLGPARRIDTAELGDSWNYGESPERYPLDVGRL
RGVIEEAARQSGWGGELPRGRARGIAAHYSFVTYVAVVIEVEVKDDGALLVHKATIAADC
GPQINPERIRSQLEGACVMGLGLAALGEISFKDGKVQQDNFHQYELARMPLAPKAVSVHL
LKPDGGPAVGRGRRARRAADSAGAVQRDLRRHRQAHPRVADPQSVAGVAEGLGPSSWSSP
A
>A0A8F7ZJ48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylovirgula sp. HY1|TrEMBL
MINLTVNGRQQSFDGDGDMPLLWYLRDIVGLTGTKFGCGVALCGACTVHLDGEAVRACQT
SVSDAQGRHVTTIEGLSPTGDHPVQIAWRAVNVPQCGYCQPGQIMQAAALLKTTPNPTDK
QIDDTMSGNICRCGTYTRIRTAIKEASGKMGAAQ
>B9BN94|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD2|TrEMBL
MITLTLNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHLDGVAIRSCIT
PVAAAAGKHVTTIEGLSADATHPLQQAWQELNVAQCGYCQAGQIMQAASLLKTNPHPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAASRGGAA
>A0A1L3I2Q6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter porticola|TrEMBL
MSTTLRINGTPHEVDLPDDVPLLWILRDEIGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGVGTPDMMAAVQKAWVANQVAQCGYCQSGQIMQAASLLAENPSPSD
AEIDEAMQGNLCRCGTYPRIRAAIHDAASMMKEA
>A0A3G7TQF4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MITASRRGFLKGGALLGGGLVVAFVIPGANRFARAASEAFVPNAFLRIAPDGVVTVVLGH
SEMGQGIWTGLSMLIAEELDADWSKIRVEHAPAAAVYGLPAFGGMQITGGSTSTWMEFDR
YRQAGAAARQMLIEAAAKRLQVAPSTLRTEQGWVVAGDQRLSYGDLANDAGQLPVPEPAS
LRLKEAKDWRLIGKPTPRLDTPEKITGRAQFGMDMYFDGLLTAVVLRSPVFGGTLKSFDP
QAALAVPGVIKVLQVPTGVAVVAEHYWAAKQGRDALKAEWDLGPNANMSSESLMQSFRKL
ALTPGTKAAEAGDAAGSMAKATQVIKAEYSVPYLAHAPMEPLNCTVRIGADKCEIWTGTQ
FQTLDQMVASKITGLKPEQVQIHTQFLGGGFGRRANPTSDFVSEAVEVAKAAAAPVKTVW
SREDDVRGGYFRSAFLHQAQIGLDAQGLPLAWQHVLVGQSIMAGTSFEASFVKNGIDNTS
VEGLADGPYLKGTPNHRVDLHSPMTGITVLWMRSVGHTHTAFVVESLIDEMADAVGKDPV
EYRRILLKDHPRHLGVLNLAVEKAGWGKPVPNGHALGVAVHESFGSYVAQVAEVSREAEQ
IRVHRVVCAVDCGIAVNPQSIVAQMESGITFGLGMALHSRISFKDGRVVQSNYHDFQVLR
LNEMPAVEVHIVASSEKPGGIGEAGVPPTTPAVANAVFALTGQRLRELPLQLAGV
>A0A2N9LRJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderiales bacterium|TrEMBL
MKRRTFLIGGLVVGAAGAGLLVGVGRIVADRVGGRDALAPRGNAVGLNGWVRIDQDGMIS
VVLSPVEMGQGVSTALPMLVAEELDVPLSMVRSERAGWEHRYGNRAVFGATWWFHPDEEQ
GWLARQLIDMGQTNGALLGVQITGGSSSVRDSYDTLRLAGASARALLIGAAAARWSVPLQ
ECSTAGGAVVHTSGKSLGYGALALDAARISVSGEVTPKSAQQRTLVGTGAPRRDIPDKVT
GAAIYCADVRLPGMLFAAVRGCPVPGGTLAGFDAAAAKAMPGVVQVLAYEGAAGCAPGVG
AIAKNSWQAQLAVSACKIQWNEGAAAAFSSEQLLAGMRVTLEGEHSGFVFHERGRGASAL
DGAARVVQADYAAPWLAHATMEPMNCTAQWTPATGQSAPRLKLWVPTQAPSFALETAARV
SGLPRDQIDLQVTQLGGGFGRRLETDYLVPAIALARAAQPTPVHAQWSREEDMTHDFYRP
AAVCRLKAGLDVKGRPVAWLTHSVSDAVTPQFLARNFPLMGALAGPLPDRTQAEGLWDQP
YEIPNRRCAHVKYETPVPIGNWRSVGHSHMAFFTESFLDELAHAAGADPLAYRQALLAAH
PRHRAVLELAAQKAGWGQGAVEGHALGIALHESFDTIVAQVAEVSIEGGRPRLHRVVCAL
DCGTVINPDIVAQQVEGSVIFALSACWYGEITFRQGRAEQTSFPSYEMVRMREAPRIETW
IVPSDAAPTGVGEPAVPPLAPAVANALFALTGKRLRSLPLRLS
>A0A7W5DF59|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. Sphag1AA|TrEMBL
MNFDQATFELPANLRALMTRDENTTEPNGLPRRSFLKLAAVGGFALGVFPMGALAQDTSA
APARPAGLKPFQQPAAFVRIDRDGTTTITINRLDFGQGVQTGLPMILAEELDADWSKVRS
VHGTNDPAYVDPAFGMHITGGSGSIKNSYMQYRELGARTRAMLVSAAAAQWKVDASTLQT
RNGVVIGPGGKQLGYGELAEAAMKLPVPENVKLKDPKDFRLIGKPTGRLDAQAKSSGHQD
YGIDMRLPGMLTAVVSHPPVFGAKLKSVDDSAAKAIKGVKAVVRVQLDRGAEGVAVVADG
YWAAKQGRDAVKLDWDTSGVEKVDSEKQLAQYRELATKPGNRKYDADVSKLGGAPHKIEA
EFVFPYLAHAPMEPLNCTVSLAGGKAEVWTGTQMPGIDGMAAAKVLGVPPENVKVHALMA
GGGFGRRGLLTSDFVAEACGVVKAAQAAGIAAPIRTLWSREDDIKGGYYRPMHLHTAKIG
FDAQGKVTAWDHVIVGQSLLMGSMFEPMMVKDGIDATAVEGMKEPYDVPMRLTVHHPKLN
VPVLWWRSVGSTHTAFVMETLLDEIARTTRQDPVAYRMKLIGDQHPRHKAALQLAVDKSG
YGKKKLDAGRAWGVAVHESFNSVVAYVVEASVKDGTPTLHNVTAGVHCNLAVNPKSVEAQ
VQGGAVMGMSMCLPGAAITLKDGVVQQSNFSDFVVPRITDAPQIAVYIVPSADAPTGMGE
PGLPPLAPAFANAVAAITGKPVRALPFKLA
>A0A7W6JX45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kyeonggiensis|TrEMBL
MKVDFGKLQKLDRRTLLVGGGVGVGLVVAWAVWPRTYLPNLSAAPGESLFGAWIKIGADG
HVSVAIPQCEEGQGVFTAMPQIIADELGANWKMVGVEPAPLNPLYANPLAAEELFALALG
GLPEQLRRTHASRTGLMLTGCSTSIRNFEDQLRHAGATARVLLCKAAARRWGVEWQSCDT
VGGQVVHGNSKLGFGELAAEAADESVPGDVPLRTAETNRLYGQPLPRLDAPAKVDGSLNF
AADIRLPNMVFASIRMGPIGETELVRLDRAAANKIPGMLSIVTTKDWVATIANNGWAAEK
AIDAMRPRFKTPEDVINNDSIADALNNALNADGARLHEAGDLAADFRGAKVVSAEYRVDV
ALHAALEPMTCTANYHDGYLSLWLPTQAPGLARAAAARAIGISESAVTVHATMAGGSFGA
KLEHEVAAQAALLSQSVGRPVQLTWPRGEDMRHDRYRPPAIGRMTGKLNGRGQISGLLAK
IAAPETGRELATRLLGGDPVVQASLALPGKGDPSAVAGAQPVYGIPNYAVDHHPATIGVP
TGYWRSGAHSYNCFFVESFLDELAHAAEQDAVSFRMAMLGGETRLARCLQTAAQLGGWQG
GQPGSGQGIACHAFRGSYIAVMAEARLDGRKVKVERLVAAVDCGRVVNPDLVAQQIEGGL
LFGMAAALAGSTGFTENVADVREISELGLPTLADAPDITVELIRNGADPGGASELAVPPV
APAIANALQSASGVRFRVLPLLSDVE
>W6KF88|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Magnetospira sp. (strain QH-2)|TrEMBL
MRYELKINGQPRSVDAEPGTPLLWVLRDLLDLTGTKFGCGVAACGSCTVLLAGEPVRSCQ
TPVEDATTGAIVTIEGANDRIATAVREAWQEKDVVQCGYCQSGQIMSAIGLLSEIPRPSD
KEIDAYMDGNVCRCATYVRIKEAIKLASGKLEG
>A0A5P3A337|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium|TrEMBL
MSIAQTFSRRPVFSRRPVNVSRRGFLAGSGALVLSTSLPARRARAQAAGAPAGPDVTAFL
ELHPDGTARLQSPFIEGGQGIFSAMAQIVGEELDLDPALFTVEAAPAGAPYDIMGGFRIT
GGSSSVRSSYMQMRQLGASARAMLLDAAAARLGVDAAELTTEPGRVIHAASGRTLPYGDL
ATAAMDLTVPAEVALKNPEEFRWIRQPLPRLDVRDKSTGKAKYGIDVHVDGMLLAAVQHA
PRLGLTPVSITNRADVEAMRGVHSVHMLDGAVAVVADRFWQARRAVEAAQVQWGPGDAQW
PMPEEFSSAAFRETLATAEGDLVQVEAEGDAGGTIDAAETVVEAIYDAPFLVHGQLEPPT
AVARFNDDGTLDVWTSCQAPEMYQGAAAAAAGVDPANVRIHSQMLGGFFGRHFLYATANP
FPQAIALAKAVGAPVKLTWTREEEFLRDAPRPLGLARFRGTVGPDGPTALFAEVVGEGPT
ARWFQAPTGQDPSATEGISGKSYGIPNRYVGQIHVPDPAVIGYWRSVGHSMHDFMYEGFL
DELAAAGGLDPFAMRMTLLAGNDRLGTLLQKVGEMSGGWQPGPYDAPDGSRRARGVAMAS
PFGSEAAAIAEVSIDGGEVRVHNLWTALDPGQIVNPATIEAQVQSAVALGVSETLVEELI
YENGQPTARNFDMYSILRPDQMPAVHVEIIESGAQMGGVGEPGLPAVPPAIVNAVATLTG
QRIRSLPLSRHDFG
>A0A653B486|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas oleovorans|TrEMBL
MITLNLNGKDHELDVADDMPLLWALRDVANLTGTKYGCGMALCGACTVNVEGQPTRSCVT
PVSAVVGKRISTIEAVAEDSVGKVVQEAWRELDVVQCGYCQSGQIMAATALLSSNKAPSD
ADIDAAMSGNICRCATYVRIRAAIHQAAEQLA
>A0A1V2XDS9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MNSHDDIDEGRRHFIVSGALFVAFSLAPASRAAAQLVIADEGAAVHVTKATQALAGSLKT
NPLLDAWVKITPDGKVTVFTGKVELGTGVRTALLQVAAEELDMKPSLITFLTADTGASPD
EGLTAGSHTMADSGSALLNATAQVRALLVEGAAKRFGVDPRVLTTADAVIKAPDGRTMTY
GDAIRTVDLHRNAAPTSPLKNPATFAVIGTSLPRVDIPNKVTGGVSYVQDMQLPGMLHAR
VVMPPVYDATLLSFDEAAILKLPGVVRIVRNGSMLAVVAQGEWQAVVAQRALAAGCRWSP
GRKLPERGTVHADLKRISTQRIEIANTHAATAPAVKTLNATFLKNYLLHGSIGPSCSVAH
LENGMMTVWTHSQGVYPLRDALAEMLSMPKASVRCIHTEGSGCYGHNAADDAAAHAALIA
AAMPGKPIRVQWMREQEHTWDHFTPAMVTEVSASLDASGRIVDWNYALWSSSHNERIVNA
GRLLPARMLEPPFVPAPSTPMLQPEGGGDRNAIPLYTLPNQHIVNNFSPTMPLQTSAMRS
LGAHTNVWAIESFMDELARAAGVDPVEFRLRHMEDHRARQVIQLAAKHFGWPRPPRARNR
GVGFAFGKYKNLMAYVAIAVEVSVVPETGQVTLEHAEAAVDAGQIVSPDGIRNQIEGGIV
QAASWTLYEALKYDTERIRSFDWSSYPILRFSAVPQNVKVHLVNRPGAPFLGAAEASMGP
TAGALANAIFDATGQRMREMPFAGDALRKRIDA
>A0A0M2WVJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. KBS0711|TrEMBL
MRIEWLNQEALQHGGVTLGAALASTPVAVVGAADGVSRRGFMKAGAVAGGGLMLGFFLPG
AGKLAQAADAAPAKPVYAPNAFLHIAPDNTVTVQVNRLEFGQGVQTSLPMLIAEELDADW
SLVHGALAPAGEQYKDAAYGMQMTGGSGSIVHSFTQYREIGAKARAMLVGAAAAQWKVNP
DQVRAAKGVLYGPGGQKATYGEFADAAMRQPVPATVKLKDPREFSIIGKPVKRLDAAAKS
TGKQQFGIDFKPPGAKVAMVARPPVFGAKVAKFDASKAKAIKGVLEVLEVKTDRGGSGVA
VIADGYWPAKQGRDALAIEWDTSAVEKVSSDRQLAAFKALAKTPGTVARPADMGKLASAP
KKIEAVYEFPYLAHAPMEPLNCVVDLQADKCTMWVGSQFQTGDQAAIAATSGLKPEQVTL
HTMMAGGGFGRRAVPSSDYVVEAVNVAKAYRAAGKSGPLKLMWSREDDIKGGYYRPSHVH
RAQIGLDAKGKILAWDHTIVGQSIMAGTPFEAFMVKNGVDGTMVEGMGEPYTLPMKLSVH
TAKANVPVLWWRSVGSTHTAFVMETLIDEAAHVAKMDPVAYRKQLIDAKHTRHIAALDLA
VAKSGYGKKKLPKGQAWGVAMHESFNSVVAYVVTASVVEGAPKLHQVWAGVHCNLAVNPL
TIEAQVQGAALMALGMTIPGAAITLKDGVVEQQNFGDYPVPRMPDMPVIEVHLVPSGDAP
TGMGEPGVPPLAPAFANALFALTGKRLRKLPFDLAAA
>A0A5E8A923|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Imperialibacter sp. EC-SDR9|TrEMBL
MAQFNLKVNGKEHQVDVDADTPLLWVLRDNLDLVGTKFGCGIAMCGACTVHVDGDAVRSC
SMPISTLGDKSVVTIEGLSADASHPLQNAWREHDVPQCGYCQAGQIMNAAALLSKNASPT
DEEIESAMNGNICRCATYNRIKAAIKTASASV
>A0A2L0HDN2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium fredii|TrEMBL
MTFSLQVNGRSYTADVDGDTPLLWVIRDVLGMTGTKFGCGQALCGACTVHVDGVAARSCV
TSIESVGESQVTTIEALHTVAHGKALQDAWTELEVPQCGYCQSGQLMSAAALLNETPKPT
DDDIDNAMSGNVCRCGTYQRVRAAIKRASASA
>A0A7Y9N6E3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis sp. JAI108|TrEMBL
MTRFSVNDRPVEYRMDPETPLLWALRDASNLTGTKYGCGTGECGACTVDIDGEAIRSCLV
TIAECEGRFVTTIEGLARDRSHPVQQAWVAEQVPQCGFCQSGMIMSAAALLRANSNPSDA
EIDAAMTGICRCGTYPRIRTAIRLAGRVMRGEERIAAAPPPGIRPEDAARAVPSLRPPRG
S
>A0A7W8QF32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia atlantica|TrEMBL
MSQGLLDAQNGAQPSDTNRHHARGISRRTFLKFGVTVGAAAGGGLLLGFSMPAASQDQKA
GKSVIGGDANEAPQSGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LDSVTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARVMLINAAAQQWQV
DPASCHAQGGQVIHAASNRSASYGQLAQAAAALPAPQNVPLKDPKNFKLIGTPAKRLDSP
EKIDGTAQFGLDVRLPGMVYAAIANCPVFGGTLASVDATHAKKIPGVREVIKLDNAVAVI
GDHTWAAKRGLQALDIKWNEGAGAQVSMKRIVDDLAAASQHGGAVARKDGDVGRAFGDAK
SRVDAIYQQPFLAHATMEPVNATVHVRGDACEIWLGSQVPTRVVDAAAAVTGLPADKIIV
HNHLLGGGFGRRLEIDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDTISAGLD
ANGKPIAWQHRIAGSSIMARFAPPAFKNGLDPDAVEVAADLPYDLPNQLVDYVRVEPHAV
PTAFWRGVGPTRGTFVVESFIDELAAHAKIDPVQYRRNLLGKSPRALNVLNVAAQAGNWG
SALPKGQGRGISVMHAFGSFFAIVVEVAVEQGEVTVKRVNCAVDCGMYVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRILRINETPPIDVHLVKSGEAPGGIGEPGTA
ALAPALTNAIYAATGTRLRQLPVGRQLHSA
>F0RB39|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cellulophaga lytica (strain ATCC 23178 / DSM 7489 / JCM 8516 / NBRC 14961 / NCIMB 1423 / VKM B-1433 / Cy l20)|TrEMBL
MPAYTVKINGKEQTVNVSEDTPLLWVLRDQLNLVGTKFGCGIGQCGACTVHINGNAVRSC
STPISVIAEKEVTTIEGLSTEGLHPVQEAWKEVDVPQCGYCQAGQIMTASAFLAKNSSPS
SEEIKSAMHGNICRCAAYNRIHKAVEVAANKLA
>F0RBY6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cellulophaga lytica (strain ATCC 23178 / DSM 7489 / JCM 8516 / NBRC 14961 / NCIMB 1423 / VKM B-1433 / Cy l20)|TrEMBL
MTKLKINGEIHTIDVDPEMPLLWAIRDIIGFTGTKFGCGKGFCGACMVLMDGNAVNSCQL
PVSAVGENELITVEGQTENLQLLQKSWAEHNVPQCGFCQSGQLITATALLNGNSNPSDED
INNAMVRNICRCGTYPRIKKAINHSVELKNKG
>A0A840BY19|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chelatococcus caeni|TrEMBL
MIKMIKLHSRTLSRRSFLITAGGFGVAVAFGGLPGQAVGAAVAPAAEGNYRPNAWVTIAA
DGIVSIMSPASEMGQGIMTTLPLLIAEEMDADWDRIRIVQAPSDAEKYGNPGFYGIQLTG
GSESTRGYYDLLRLTGAQTRKVILASAAGMLNVPVGELTTEPGRVVHARSGRSFGYGEIA
ADGALPDPLPQATEADLKPADRWRYIGRRTVQRVDVPSKVDGSAIYGMDVQRPGMLYGTV
LRAPVQGERPEAIDDAESRAVPGVVQIVPLSYGVGIIGETVEATQRAKDLLKVTWSRSSR
VRSYTSGSLLEHYRSVGRDLSQTGVEALSEGDAEGALAGAVTVITADYMSDLVCHATMEP
MNATALVKGDSVEIWAPTQGPTHTQRFAAEVVGTTPDRVKVNTTLLGGGFGRKAEADFIV
DAVSLAREVEGRPVKVIWSREDDIRHDKFRPLEAQHIQVGLDADGNILGWRHRIVADSIF
ARTMPDLFASRGGHDDVVTEGAQFNYAVPAHRIEYIRQDNGLDIGFWFAVGVGYTRFGIE
CVIDEVAAATGADPVQLRLKLLPEQPRARNVIETVAAMAEWDRKRDGRALGLAYSDAFGS
HCAQIAEVSLNRETGAIRVHKVWCAVDPGVAIQPVHIEGMMIVGIANGISHALFEQINIV
NGEVQEGNFDTYRVIRMSEAPDIEVAIVPTSGSPVGGMGQVGLPPVGPAIANAVARLTGG
VRLRHYPFLTERVLEALGA
>A0A564FTW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium dankookense|TrEMBL
MLKIRQPTTEPRASRRAFLAGGAAAAGALMIGFRLDLRGARAEGAPDLSAVKANPNAFVR
IAADDTVTVIVKHLDMGQGNTTGLATILADELDADWSKVRTEFAPADAALYNNLLMGPVQ
GTGGSTAIANSWMQLRKAGAAAREMLVAAAALDWKVPALQITVENGVVRHAASNREASFG
KLAAAAAAMPVPQEPRLKDLSQWRLIGQTVPRLDSVAKTSGSAVYALDIRRPNQVTAVVA
HPPRFGATVKGFDDKAARKVAGVIDVVAIPTGVAVIARDTWAAMKGREALSVTWDESLAE
SRSSDAILAEYRETAKRPGLVASQRGDAEAGIKGAAKVLEAEFSFPYLAHAAMEPLNATI
ERAADGGYDIYAGLQFQTVEQATAAAVLGTTPDKVRLHTTWAGGSFGRRATPSADYIAEA
AAILKAWGAKAPVHLVWTREDDMAGGYYRPTVYHKIRAGLDAKGSVTGWQHVMVGKSIMI
GSPFEAMLVKNGVDGTTVEGASDTPYALPAYRFDVHNAREGVPVLWWRSVGHTHTAQAME
VFVDELAHAANVDPVAYRLALLTNAPRLSGVLKLAAEKAGWGKGASGKGRAMGVAAHESF
GSYVAMVADVTAGSGSVKVNRIVAAVDVGIAVNPDIVRAQVEGAVGFALSSVLRNRVTLK
DGVVQETNFDAYEPTRLTEMPVVEVHIMPSRAAPTGIGEPGVPVLAPSISNAVFAATGQR
LRSLPLDLSGLKGV
>A0A379YTR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella baltica|TrEMBL
MSTFTAVENISRRDVLKLFGAVGGGLALGASGLTWSPMALAQDKEARLNLFIAIGEDDKV
YLTCHRSEMGQGIRTGILQVLAEELEADWDKIVPIQGLADKRYASQNTDGSRSIRENYDR
MRQMGAMARIMLEQAAAARWKVPVSEVHTADHKVLHAKSGRSAKFGELALAASKQPVPAV
ESLTFKEVKDFKQIGASRQIVDMDAMLSGSAIYGYDIKLDGMLYASIMRPPVLGSDVASL
DDTAARKVAGVVGVYRLPAAKGAPAFQALGGVAVIATNTWSALEGRKALKVTWTQADNSQ
HDSSLYLKELVERVQQSGNVVRQAGDEIKNWPEANTLKAVYTVPYLIHSSIEPPVATAHV
TEKGCEIWASTQTPQSTQQNVAAALGMEEDTIKVNVTLLGGGFGRKSKPDFSVEAALLSK
QFKRPIKVSWSREDEIQNGYYHAISAQSYQALFDANNKPTALLARTGFPSISSTFAEGVE
YPSGGELDLGFVDVPFALPNLRYEAVKAQAHSRIGWMRSVCNIQHGFSVGSFVDEMAHRS
QVSCFEMWRSLLGEARRETFSDQGFKYGNYGEDLSRHPVDVSRYFGVIDAVEKAQAKAPK
AGKNQGWGFAVHRSFVSYVAVAMLVEVSEDKQLKVLNTIAAIDAGTIVNPDRVKAQTEGA
IVFGLSLALMGEITYKEGKVQQSNFHDYPLLRIPQTPDIEIIIIESDAAPAGVGEPGVPP
VAPSLTNAIFAATGQRIRDLPVSKLLRV
>A0A5B9MK97|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stieleria maiorica|TrEMBL
MNAPTKARKGISRRSFLAAASAGSLVLMAKVTHGQDVVVVGATKANLESFDPDLFVSIAP
DGTVSILAHRSEMGTGIRTSLPRIVADELEADWARVEIVQAIGDKRLGDQNTDGSNSIRF
FFDRMRIAGATARTMLERAAAQQWGVAADQCHGDNHRVVHSDSDRAIGYGELVSIAKTLD
VPAADELKLKPASKFRYIGKDAPITDMDAILTGKAIYGIDARMENQLYAVIARPPVVGAA
VKSYDAADAMEILGVVDVVEIPKFDGAPLFQPLGGIAVCAESTWAAWQGRDALEIEWDEG
PNASYDTDQFAKTLAESANRPGKAVRNHGDAGKVIAESDNVHRADYTVPHLSHAPMETPC
AVADVKTEGDKVVSCIVTAATQNPQAVQQAVGPAMGMKPEDVIVNVTLLGSGFGRKSKPD
YCVEAAMLSRKLGRPVHVTWTREDDIHNDYFHTMSHLHLEAAVDEKGNPTAWLARAAYPT
IGSTFNPSAKEPAGFEVEMGLTDCPYQIPNLRVEVGQAVAHTRIGWLRSVAHIQQNFAVG
SFADELAHHAGRDPYQYLLELLGEDRHLDLEAAGLSNRGASATDYPYDIARLKAVTRRVA
ELADWQRGKDLPKGRGLGIACCRAFLGYTAHVIEVDISEDGKLRIPKVWVSLDAGLIVSP
DRVRAQVEGAAVMATTQARYGKITFKNGRAQQGNYDDYPMVTMSDAPREIIVDVVDSQAA
PAGVGETTVPSFAPALCNAIFAATGKRIRDLPLRDHDLSWS
>A0A166QP15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Frankia sp. EI5c|TrEMBL
MHERIGRRRFLGYVLAGPTLVTAAEIGLASAAASAPEAGVQLPSQDITDVVDLNDMMTLA
ALPTSALISVEVGPDGLVSFALPRAEVGQGITTSTAMLIAEELSVPLSRVRVTLADARPE
LLFNQLTGGSNTTFATYTPIRVAAAIARRRLLDAAATELGSAVTDLSLRDGAVVSRSGRS
IDIGALAEKAASLRNQQVSVELTARENFTVIGRPHSRVDALDAVTGRKKFAMDLDVPNAK
PTMVCRPPTINGKVGSVANLAEVRAMPGVTDVVEISTGVAVRAETFGQCIDAVRALRVTW
KAGTAAGKSDETVRRELERAELPLGLPPLTPAVEGKFTFYFRSNSALEPNCAVADVRADR
AEIWAALKSPIVAQKTIAAKLGLSPAKVAVHVVEGGGSFGRKLFFDAALEAAEVSKKVGK
PVKLMWHRADDSRQGRTHPMATSRVRASYLGGTVLGYHQRHTSVATDLGHGLGEIITATA
AQLPVGDIGFSEIFFQLSQTMPYDFGVHSRLLAETDKGFNTGSMRNVYSPDMTCARELIV
DQLAARMRKDPYRFRRDFLRDDRSRAVLDKVAEVGGWGRAMPAGTAXGIAFHSEYKSVSA
VLVEIDCRPETVNRPIRDGVAGPRVTKAVFAVDVGLAVNPRGLEAQMMGGVSDGIALALT
SSLHLRDGYFLEASWDNYFYTRQWNTPPDLKIIIMPSTSEKPGGAGELGVAGAMAAVACA
YGRATGTMPTSFPINHGTLSFEPKPTVPPVPPSPTDGLNYAS
>A0A1J5Q954|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MRITVNGTPREVSAAPDTPLLWVLRDELGMTGTKFGCGAGLCGACTVQVNGVAQRSCQMA
LGDVGSAQITTIEGIGTPEKLSVLQTVWVEHQVAQCGYCQSGQIMQAAALLATTPQPTDT
EIDDAMSGNLCRCGTYPRIRAAIHDAAQRLQKV
>A0A0M6Y3T2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium aggregatum|TrEMBL
MELNINGSRHQVDVEPDTPLLWVLRDTLGMTGTKYGCGLAQCGACTVLVDGYATRTCVTP
VESVAGSEITTIEAIEQDPIGRKVVDAWVENQVPQCGYCQSGQVMAATSLLKENASPSED
DIAAAMTNLCRCGTYNAISKAVRQAAEA
>S6DBL0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus 386B|TrEMBL
MSTHSPSSTTRLKTSRRRVLQAGGALLLATLWPTARGRAAQATQAGTGMLVEDVATPFAP
NAFIRIAADNTITLILPNIEMGQGIYTSSVMLMAEELGIDPFAVQIEAAPPGGGAEITGG
STSIMTEWLPLRQAGAAARTMLVQAAASHWGVAPESCTTANGAVVHTPTGRTVPFGDVAE
AAAKLPVPKEPKLKDAANYTLIGRKHHRLDSQIKVDGTARFGMDVQVPGMKIGTVAACPV
QGGTVRSMNRNAALAVNGVHAVLVTDNKDTVCVVAEHYWAARKGLKALHIQWDFGKNAAI
TTQTIYDDLHAGLNGPAIVANAKADAPGVIGKSGATYTATYQQPLLAHSPMEPINCTAHV
RPDGCDVWAGTQVAERARDTAAEITGLPASKITVHSQYIGGGFGRRLEHEYVTQCVQFAK
QVPYPLKIIWSREEDITKDRYRPAYVDKLTAALDDKGYITALQHRIVGPAVVARWDPPEL
TKDGYDEDLSLATVVTPYTYPAYRLEFARREAPGITTAWWRGVGGTRGLFVVEGFIDELA
ARAGTDPVAYRRAMVQNNPRALAVLERAAADAGWGTPVPKGRARGVALQFAFGSYMASIA
EIEMPSPDEVIIHRVTAAVDCGQVINPDQVIAQIEGGLIFGFSAALHNEITLENGRVQQQ
NFNTWRVMRMNEAPRRIDVVVMPSKEDPGGIGEVGTAAAAPLLANAMAAAQGRRYRSLPL
LSARNTEGKE
>A0A4U9HIE6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MNLRDHDLAALGEQPVNLSRRRFLLAGGSLAGVLVLGVGLPVGQGRAQTAQASPAPGTRV
PAFLEIRPDSSVKFLSPFIEGGQGIFTAMAQIVGEELDADPATFIVENAPAGSEYQVMDS
GMRITGGSQSVRSSYTTMRRLGALARQMLLQAAAAQLSVPVEQLHTEPGCVIHALSGRSL
SYGELAARARDLAVPSPDSVTLKDPARFRWIGKPVQRLDMHEKSTGKAVYTIDCRVDGML
HAAVQHAPRLGLHAGQLRNEEQVKAMKGVHSVHVLPGAVAVVAERWWQAKRAAEALQVEW
LEPDAPDGNYMPADFSSEAFAAALAQEPGEGEDAEVKGEPAQAMSAAQTTLSATYHSQYL
NHAQLEPPSALARFNDDGTLELWIPNQAPEMFQADVAKRTGLAPEKIIIHSPLLGGFFGR
HFVYDTAMVYPQAIALAKAVGRPIKLIWSREEEFLRDTHRPMAAVRFRAGLDAEGYPVAL
EAISICEGPSEAQTGKHGDQLDPSALEGLTGKAYAIPNVRIAQIYKKGPVRLGYWRSVGN
SMNDFLYECFLDEIADKSKLDPFALRLHLLQGSQRLTTLLNAVAEMSGGWQAGPYTAADG
SRRARGVAMASPFGSEAAAIAEVSIEQGQVRVHQVWEAIDPGSIVNPAIIEAQVNSAVAL
GLSQVLLEESVYEKGQPVARNYDMYPILPPSRMAQVQVRIIESGAKMGGIGEPPLPPYRR
PWRMPSPA
>A0A3G7C4D0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MITASRRGFLKGGALLGGGLVVAFVIPGANRFARAASEEFVPNAFLRIAPDGVVTVVLGH
SEMGQGIWTGLSMLIAEELDADWSKIRVEHAPAAAVYGLPAFGGMQITGGSTSTWMEFDR
YRQAGAAARQMLIEAAAKRLQVVPSTLHTEQGWVVAGKQRLSYGDLANDAGQLPVPDPTL
LRLKEAKDWRLIGKPTKRLDTPEKITGRAQFGMDMYFDGLLTAVVLRSPVFGGTLKSFDP
QAALAVPGVLKVLQVPTGVAVVAEHYWAAKQGRDVLKAEWDLGPNANMSSESLMQSFRKL
ALTPGTKAAEAGDATGSMAKATQVIKAEYSVPYLAHAPMEPLNCTVRIGADKCEIWTGTQ
FQTLDQMVASKITGLKPEQVQIHTQFLGGGFGRRANPTSDFVSEAVEVAKAAAAPVKTVW
SREDDVRGGYFRSAFLHQAQVGLDAQGLPLAWQHVLVGQSIMAGTSFEASFVKNGIDNTS
VEGLADGPYLKGTPNHRVDLHSPMTGITVLWMRSVGHTHTAFVVESLIDEMADAVGKDPV
EYRRILLKDHPRHLGVLNLAVEKASWGKPVANGHALGVAVHESFGSYVAQVVEVSQEAER
IRVHRVVCAVDCGIAVNPQSIAAQMESGITFGLGMALHSRISFKDGRVVQSNYHDFQVLR
LNEMPQVEVHIVASTDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLAGV
>A0A3S5AS01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MELNINNKIYQTDADADTPLLWVIRDDLAMTGTKYGCGLAQCGACAVMVDGQAVRSCVTP
LETVAGKKITTIEAIESDDVGQRVVAAWVKHQVPQCGYCQSGQVMAATALLKHNAHPSDE
EIAAAMVNLCRCGTYNAISAAIHEVAGKGDKV
>A0A386UR77|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paracoccus yeei|TrEMBL
MTVQTTRRGFLAGGTGLLLALALPVGRGRAQVTVAGPFAPNAFVRIGTDDLVTVMIKHLE
MGQGPYTGLATLVAEELDADWSQMRAEGAPADDRLYANLAFGAQGTGGSTAIANSFMQMR
KAGAAARAMLVAAAAEEWGVPASEITVKAGVVAHEASGRSSGFGALSTAAARQPVPEDPP
VKAPADFVLIGTDRPKLDSASKSTGTAQFTLDVYRDGMLTVVVAHPPRFGATLARVDDSA
ALAVKGVEMVRTVPSGVAVYATNTYAALKGRDALILEWDDSKAETRSSTQMFAAFAEAAA
QGGETVEEEGDLSAIDGAARVLTAEYRFPYLAHAPMEPLDAVIETKGGKAELWFGSQFPS
FDKPTIAGALGIAPEDVTINVLMAGGSFGRRAQGSAHLAAEVGEIARAAGRDGAFKLVWT
REDDVKGGYYRPMTVHRLRAGLDADGAIVGWENVIANQSIMAGTPMEAMLKGGPDNSSFE
GSTGLPYRLGARRIGWARMESPVSVLWWRSVGHTHTAYAVETFLDEVLEAAGKDPVQGRL
DLLPPDAARERAVIAEAARMSGWQGPRRDGKGYGIAYAKSFGTYVAEVVEVEDRAGTPRV
TRVWCAVDCGIAVNPNVIRAQMEGGIGYALSAALHSRITLAPGGTVEQSNFHDYPMLRIA
EMPAVEVSIIRSDADPTGVGEPGVPPLAPAMANAWRALNGARQYQLPFGGAIS
>A0A4U9HCL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MRGGLDAARQVAAYDFKTCYPSNNAVTLALVLSGKVANQADVQQMGDRTAIPQYRYPHMR
VVAQDAAPIVRASWMRGVSALPNVFAHESWIDELAYLADDDPIAYRLRYLDDPRALTLIE
ALKKQAGWRPGRAHRHLAPASQEWVSGRGFAYARYFHSKFPGFGAAWAAWVCDLVVSRRT
GQIKVKKVFVAHDCGRIVNPAGVRHQVHGNVIQSTSRAIKEFATFDGAGTTSLEWGGYPI
LRFDELPDVDVQLLDNPDQPPMGAGESASVPSAAAIGNALFDALGVRLREVPFTPERILQ
ALTSAH
>A0A0S4UCI6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MRIRNLEALAGGGVHDPAAPACADASVATLDRRSFLKLTALAGGGFALGVAPMLAGAQDA
AAKPPSPPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAG
DPYKDPLFGIQLTGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSACRTANGVVI
AGSRRATYGELAQAAMALPVPRQVALKNPSQFRIVGKPTPRLDARAKLDASLKFGIDTRL
PDMKVAVVARPPRFGGKVTKYDAAAAKAVKGVVDVVPIQTDRGGTGVAVIADGYWPAKQG
RDALQATWDDAGSRVSSAALMREYKTLADQPGTVAKAADVGAIQSAAKRIRADYEFPYLA
HAPMEPLNCTIDLQSAGGKVSGAKVWVGTQFQTVDQGALAKALGIAPEKVELNTMMAGGG
FGRRAVPTSDYLVEAANVAKAYAAAGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKGTPFESYMLKNGVDATMTEGVIENDYGFPMQVSVHHPDVDVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPVAYRLARFTDKEHERHRQALRLAVDKSGY
GKRKLPKGQAWGVAVHASFESVVAYVVEVSIDQGKPRVHRVTAGVHANRVINPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGAARNSNFPDFPPVRMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDTV
>A0A221UZB7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arenibacter algicola|TrEMBL
MTRIKTQYNRRSFIKVSAAAGGGMLIGFSWLNGCKPNTPEPEPGVAMPKEWFEINGYIKI
GDTGLVTIYSPNPEIGQNVRTSMPMIVAEELDVPWKNVVVEQAPLNTGWYQNQFAGGSLS
IRLSWNALRMAGATGRRMLMEAAAKEWGVQVSDLNASNGVIKENTGERTVTYGEIASKAV
GIEVPKEVELKGVKDFKLIGTSIKNVDGKKIVTGQPLFGLDFHRDGMQLAMIQHPPAFGM
TIKDFNEAEIKSMPGVEDAFIVDTTVEEPGGFDEKGFKQLIAIVGDSTWELMQAKKALKA
NWETTGELESSEMHLKRLEKALVSGQVMESRKDGNPEAAFKKASKIIERTYSAPFIAHNT
LEPMNFFANVTADSAELIGPTQTPEALEGSVAKLLNLPLENVTVNMTRIGGGFGRRLYVH
FGVEAAAISKKIGAPVKLIYSREDDMTQGTYRPTYRSVYKAGLDENNNLIAFTVKGAGLP
EGPVFPNRFPAGAVENYSAEKIKAPTNVTTGAWRAPRSNFTAGAEQAFLDEVAEAAGKDP
IDFRLELFDRAIKDPVGEKHEYEADRYAGVLKLVKEKANWGTTKPNVHRGVAAYFCHSTY
VAEVFDMVLNNGQPIVEKVWCAVDCGIVVNKDAAKNMIQGGVIDGIGHSMYSRLTFENGA
PNQMNFDKYQLIRHSQAPKEIEVFFVENEIDPTGLGEPGLPPAIGALANALYKATGQRHY
HQPFVTEKQVLG
>A0A221US71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arenibacter algicola|TrEMBL
MATFQLDINNSKHKVEVAEGTSLLWVLREHLGLTGTKYSCGIGQCGACMVHIDNQPVRAC
LLQVDNYADGQKIKTIEGLSQNGDHPLQKAWIEAQAPQCGYCQSGQIMQAVALLETNPNP
TREEIKTHMNGILCRCGTYLRIIKAIELAAKTPTSIEK
>A0A128F5Y6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia celer|TrEMBL
MRDFLNGYVPEEAFLKNTKQVGTSRRNFIKLMSTAGAGLTLGVHLPSVAAGASETAGKPF
EPNAFVRVGSDDSVTIMIKHLDMGQGVTTGLATIAADELDADWSKVTTEAAPANANEYNN
LLFGPVQGTGGSTAIANSFMQLRMAGAKAKTMLVNAAAKVWEVPAAEITASNSTLSHSGT
AKSASYGEMAELAALQSVPADDQVVLKTPEQFTIIGRTGTARKDKGKSNGTATFTQDVQL
DGMLTALVAHPPAFGAKVVSFDATAAKQSPGVVDVVQIPTGIAVVAKDFWSAKTGRDKLS
IEWDRSEFTKNTEQLKTEYTALAQTPGLAARNDGEAGKVLEIAENVVEATYYFPYLSHSP
MEPMNCVVLAGDGKAELWYGAQIQTIDQFAVATVLGIKPENVTINTLFAGGSFGRRANPQ
ADYVVEATMIAKTQPGVPVKLVWTREDDMRAGYYRPMYIHKIRGAVDDEGNITAWEQRIV
GQSIAAGTAFEDFMVKDGVDSSSVEGASTLPYAIPNLAVELHTVQQPVPVLWWRSVGHTH
TAFSTEAFLDELAHKAGKDPVEMRRGLLKNHPRHLGVLNLAVEKSDWGKPLPKGKGRGIA
VHESFRTFVAQVVEVTVENGQITVDKVVCAVDCGVAINPDIIKTQMQGGIGFGLSPALVS
EITLQDGATVQSNFHDYLVLREMQMPEIEVHIVPSAESPTGVGEPGTPPIAPAVANAVFA
ATGQRLHDLPMKLS
>A0A166A776|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio axinellae|TrEMBL
MSRLGKYTRRAFLGLGVAAAGGLAVGYYFYQKPYANPLDAKKAEGETPFNPYVMIDADNT
ITIIAPRAEMGQGVHTTLAALVAEELEVPLEQVKVEHGPSSPAYFNAALLEDGTPFPFYD
ESVLAELARGSMKIVAKFLGINATGGSTSTTDAFVKMREAGYAARYVLIKAAEEHFGTTK
DNLIVADATITEKSSGKSVTYGELASKAVAISPPTEMKLKKASDWKILGKSQDRVELKDK
VTGGRIFGIDMQLPDMLYGTVRMAPRKGVSLKSYDKTAALAIPGVKDVVEIKTATGEGLG
IIAENTWAAFQGSQALVIEWDDPLTLQNSDQMWNALETALTKEATFELGGTGSDPEVFAS
IPEKETLSAQYRVPFLAHATMEPMNATAQHEGDTIYIWTGTQAPGLVQSAVASHFDMDSA
DIDITTTRLGGGFGRRLEVDFSLYAAVIAKATAPYPVKVTWTREEDTQHDTYRPMAIAEI
KGQITPSGTLKTFDMHVASPSIVKSVMARTFPGLSPVGPDNSVLDGAFNQPLDAENQRYQ
AHVSDLLVPVGFWRSVGNSVNGFFHESFMDEAAHKAGVDPVEFRLAQMTNDEFMPAREVL
KRVAEISGWGTPLPAGKGRGVAHVLSFGTWTAQVVQVDVTDETVTIEEVWAVADPGIVLD
PGLFKDQIMSGINFGLSQAFGEEITWSDGEVEQANFDTFDAMRMYQAPKITVEVLENSPK
MGGAGEPGTPPSTPALANAIFAATGKRIRQMPLSNEIDFI
>A0A1N6VKB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella morhuae|TrEMBL
MAKFILNGKPVAADVDGETPLLWVIRDELDMTGTKFGCGIGTCGACTVHVGGRATRSCVT
PISAVEGASITTIEGLSETGAHPLQISWQKHQVPQCGYCQSGQIMQAAALLKDIPQPTDA
EIDAVMSGNLCRCMTYVRIREAIHEAADSMKEASHVKIA
>A0A375J4Z2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSHLHTSRRRFLQAAGAMPAALVLGFHLPLAKAADARAPARDPDDVNAWLRIDVDGSVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQSWSVPVAQCRAVQGVVRHEPSGRTLGYGALAARAATLPR
PASVALKEPRDWKLLGRPTDRLDVPLKTRGAAVFGVDVRVPRMLVGSVMACPAFGGTLRR
VDARPALALRGVRRVVPLDDAVVVLADSYWTARKGLAALRPEWQLPQGKPASDAALMAAY
RDAARSASAVALRHGDPDTQLQEAQAYTAEYEVPYLAHATMEPMNATADVRADGAEIWGP
TQVCGEIAQRLSGALGLPADRIAVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPDAAGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAKADPLQFR
LNLLADRPRPARLLQRLAQHVGWGSAPAGRCHGVALSQAWGSLCATVVELSVQDRRITLH
RVVNAIDCGTVINPATVERQLEGASIWGLSAAMTGAITIADGRVQQSNFHDYPLLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGQRLRSLPLARHGFELA
>A0A375BXY5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVMRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLESVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLLARAARQLGVDASTLEAENGGFRVPDTQASIRYAALV
AGAHVELPLADDVPTKPVESYRIVGRAAPRVDIPDKARAALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLAVERDSVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
QPVPPLPALDDPEPALRANPATRRELLSEGELPADGAGTVLRRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGVVPNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDQRAADLLRAVAEAAGWQRGAAGARGVPDAEGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRITIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVVLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVAETVLAAMASMSSSKR
>A1TZ33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8)|TrEMBL
MAMNRRDFLKVSTSASGGLLLALNLPGCASVQTGYEPETGEWKPNAWLELTRDNDIIFTL
DRVEMGQGTYTGLTTLIAEELDVAPEAIRVEFAPVAPEYRNPLFGLQLTGGSTSVASSWQ
PLREAGASARLMLVMAAARVWRVEPGQCKTEGGYVRHPNGLDSMPYGKLVELADKEVIRG
DVPLKPRSQWKYIGRQAGRLDAEAKSTGQAMYGIDVELPDMVYAVMTRSPRYGGLAVSFN
RDQVRAMPGVLDAFITERGVAVVADRYWRARKAQEALAVEWDFSEAVGLSNPDVFKHYRQ
AAGEDPGEDERVDGDPEAVLEKGSTLVEAEYEQPYLAHATMEPMNATAWYRDGGMEVWAP
TQAPDLGRIAAARHTDLSPDDVTIHTTFLGGGFGRRLTQDYIEEAALVAYRVKVPVKLIW
SREEDTRHGFFRPAMLHRMAASLEDGQLTGWDHQIVGPQILDWYVRNAAPAQYPWAPKLL
YGTLGRVGLMVEGIATPKDISAIEGAIGYPYAVPNVRVRHTHTDPGVPITWWRSVGYSHN
GFAVETFMDELANQANEDPVSFRLKLLESEPLHRRVLERAAELAGWNQPVPEGRARGVAL
FKSFGTYVAQVVEASIEQGGIRVHKVTCSVDCGQVVNPRIVEDQMTGGIVFGLTAALNGE
ITLDGGEVQQSNFHDYRLLHMHQVPEIVVDIVDSEEPPTGVGEPGVPPVIPALGNALFAL
TGKRQRRLPLKA
>A0A2X4UKK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia plymuthica|TrEMBL
MAISEVPTSREGAVKKLMEHPLLLSVNGKSIHTQVMTDTPLLLVLRNDLALNGPKYGCGL
GECGACTVLIDGIAARSCVIPALGVADRAITTLEGLGDRDHLHPVQRAFIEEQAAQCGYC
LNGMIMTTKALLDRNPSPSDGEIRQALSGNLCRCGTHIEILRAVQRAIILCRNEETPHD
>A0A4P8HZB9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MNKANDGQVTSRREFLKLSITVGGSIVVGVGYYGTAHATPEDSAFSPNAYVRIAPDNSVT
VICGKSEMGQGVHTAYAQIVAEELDADWSTIVVEQAPVHLDHANPGTPLMATGGSTSVRM
NWDRLRRAGAGARFVLLEAAARSWRVDKSQLHARAGWIHGPDGRKARFADFLKACAGIEL
PQAPPLKSPSEYTVIGRPLLRVDTPPKVTGQAQFGIDVQLPGMLLAVMAFPPAFGATVIE
FDPKPALAIAGVRGVFQVTGGIAVVADTTWAAMKGREALSVRWSKSPFADLSMDALRQQY
RAALDHPGLVDKESGMSTVKTKSSLTMDFEQPYLVQAPMEPMNCTVEIRADGADVWTGTQ
GQSLAQRYAAGVTGLKPEQIRVHTTFLGGSFGRRGVNDFVRHAAEIAKAAGKPVKMLYTR
ADDMRAGYYRPFNRIRISATLGHDGRIASFTAKTAVAAISKWTGFSALKKPNGVDHYATE
TLAPFYDIEHVEVRWVETDPGIPIWFWRTPGGSQNCFAVESMVDELALLAGRDPYTFRRS
MLTSRPRHIAVLDLAAKHAGWNRPAPSGSARGIAIVEIFGSIVAEVAEVKIVDGSVRVVR
VTCAIDCGTAINPQQIRAQAESSIVFGLGALLYGDVTIEGGAVQQSNFHDYQVLRMQEMP
AIDVHIVPSEAPPGGMGEPALPPVLPAVTNALRVLTGKRINQLPVRLTSDG
>A0A840U9D1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter oulmenensis|TrEMBL
MSRQDDSLMLANVSRRGLLKGMAGASALLLAARWDSGLANEKAQFGAGAMPGGWVDNPNV
FIQIAADGQVTFINNRAEMGQGIRTSLAMVAADELGADWKRVRAEQAPADQDKYGNQNTD
GSRSMRHWYEPMRRAGAAARLMLEQAAANQWGVPVSEVRTGVHKVMHPATGRELGFGELA
QAARELEVPGRNALILKSPSELRYIGKESGLINGELKSAYPKAVDGEDIVTGKAIYGADV
ELDGTVYAVIARPPVYGARIRSVDDSKALEVPGVQRTIRIETASQPAAFNPLGGVAVVAS
NTWAALEGRKALNIEWDLGPAGDNAGYDSEQYRQSLEEAAQSPGRVIRQSGDVASALESA
DSRVAATYYMPHMAQAPMEPPVAVVRVSNGKAEAWAPVQNPRATRDGIAGVLGLDRENVT
VHQTLLGGGFGRKSKPDFVAEAARIAREMNGTPVKLQWSREDDIQHAYFHTVSVDHLEAG
LNADGKATGWRHRTLSPSITSLFAPDPEHKGEFELGMGFNTLPFDIPSIRLENPPAPAHV
RIGWFRSVYNLPHAWAIQSFAHELSVAAGRDHRDYLLDLLGPDREVHNLEVGDGWNYGED
PNLYPIDTGRMRRVIERATEEAGWGRETGDRRGLGLAFHYSFLSYTAIVFDVEVSDDGDL
TIHRADIAFDCGPQANPERIRSQLEGACVMGIGVALKSEVTFQDGVAQQSNFNNYLIPRI
ADAPEVVRVHLIDNPDDAMGGVGEPGLPPVAPALCNAIYAATGKRIRSLPVGDQLRSS
>A0A846UTI1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. SG609|TrEMBL
MAQAQALASKPTSSITPEKVREGIAVEINGRPFRHTGDPDMPLLWYLRDVLRLTGTKYAS
DHGLGGADLVLVNNKPVSAVSVPMHELADKKITTVEGLAAADGKLHPLQQAFVDEDAIGC
GYCTPGWLIASLDLLNRHPQPTDDQIDQLPNLCRCGCQTRVRRAIKRAAAAMAGGRA
>A0A7W9BFG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas aerophila|TrEMBL
MTRFTVNNQPVEYRLDPQTPLLWALRDASNLTGTKYGCGTGQCGACTVDVDGQARRSCQV
AIGTIEGSYVTTIEGLSRERNHPVQLAFLAENVVQCGFCIPGFVMAAAALLRRNPDPSEQ
VIRDTLTNLCRCGVYPRVVEAVQRAGRAMRGEELIPAGPRPGIEPADSARLVPAFAPPSR
P
>A0A841HLB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MSAVEQSVLADSPSRELMQAAEQRAGALPSLDRRSFLKISGMAGGGLLLAFHVGSEALAN
GAPKGFVPNAFVRIAPDGTIVIYSKGPEIGQGIKTAFPMIVAEELDADWARVKVEQAAVN
PTVFGRQSAGGSRSIPMAWDQLRRAGATARAMLVAAAAKEWGVPESEITTSSSVASHAAS
NRSLGYGDLAGKAADLPVPDAKALKLKDRKDFKLLGKRITGVENVEVVTGKPLFGIDQVV
PGMQIAVFEKCPAVGGKVQSANLDEIKKLPGVTNAFIVEGNGKPTEVMPGVAILASSTWA
AFSAKRQLKITWDESSASKDSWSKSVEDAKKLASSQGPESLKAVGDFDKALANASVAEGF
YTYPFVSHAPLEPQNCTASFKDGAVEIWAPSQTADAALRLVAGTLGIPVEKVTIHQTRVG
GGFGRRLMNDYVCEAAWISRQAGVPVKLQWTREDDMHHDFYRVGGFHSFKGGVDSDGKLV
AWQDHFITFTQDGEKPALAGQMSGDEFPSLLVPNVRITQSKLPLATPTGWWRAPGSCALA
FAIQSFLHECSVSAKRDHLQFLIDLMGEPRWLAPKNEFALNTERAVAVIKLAAQKGGWGR
KMPKGSGLGLAFHFSHAGHFAEVAEVSVDANRKLTVHRVTVAGDVGPIVNMSGAENQVEG
SVIDGFSTMGLEISIENGRIQQNNFDSYPLLRIAKAPKVETHFIQSDYSPTGVGEPALPP
VAPAICNAIFAATGHRVRTLPLSKEGFSV
>A0A380AZY5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia quinivorans|TrEMBL
MEIKINGRMVALDDVSPETPLLYVLRNDLGLNGPKYGCGLGECGACTVLVDGVAARSCSI
PLSGALNKSITTLEGLGEAGQLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFERNPQADE
QQIKNELAYNLCRCGTHIEILRAAAKARQLLAERGQA
>A0A1K0JG45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator|TrEMBL
MKLQINEKTYEVQADADTPLLWVIRDELGLTGTKYGCGLAQCGACSVLVDGVAMRSCVVP
VEGLAGRRITTIESIEEDEVGKRVVQAWVRHQVPQCGYCQSGQVMAATALLKQTPHPTDE
QIAAAMVNLCRCGTYNAINAAVHDVAGNPVNRAAAAGIPEQAPDQEGGMGKAAAVAAIAL
VGIGAAAGVMRNRASNTNEQGDDV
>A0A1Y6KU70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MNQHVKAAPAMTPDMATDLSRRSFLVGTAATGLVLGYAGLADSALAATTPSAFEPSVWYS
IAPDGLVTVTCGKADMGQHIASTMAQIVCEELGAAWKDMRVQLASNDPKFNDPVLGAQIT
GGSWSTMMNFDAMSRAGAAGRIALTEAAATSMGVPAKELVVRDGLVMHPKSKKQMSYAEI
VKSGKITKSFTPDELKAITLKTPDQYTMIGVSVPQLDIPSKTNGTAKYGIDTMLPGMVYG
KVVTPPVRFGATVTSVDDSEAKKVPGFIKAVVLDDKTGSTSGWVVAVASTFANAKKAADA
LKISYDKGPYANVSTDTIITEAMRLQAQDDAGQFFVKDGDANAALAGAVKVLEAEYTTSI
NIHAPMEPMNATAEFKGDILHIYSGNQFATRSGAIAAGAAGIDPKYVVMHQAWLGGGFGR
RLDADMMVPAVQAAKAVGKPVKVIYSRENDMTMDYSRPLTYQKVKAGLDASGKLVALSHD
VVSAWPTARWGIPDFLSPSVDKKGPLDSFTVNGADFFYTVPNHHVRAIKNELAHNATPSG
QLRSVAPGWTFWAVESMIDEIAAASGQDPAQFRIALLDGKGKNDGGAQRLRNTLLAAMGL
SGYGAKKLPKGEGMGVACVSSQERATASWTACVAHVAVADNGAVTVKKLTVATDVGTQVH
PDNIRAQVEGAALWGLSLAMYEKATLKDGGIEQTNFDSYTPLRMSQVPEVAIAVIANGEK
ATGVGEPAVTVVAPALGNAIYNACGARLRSLPITAEAVKAAMKA
>A0A379A038|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pannonibacter phragmitetus|TrEMBL
MLHRIVSPLTAAAPSRRGFLKLSAGAAGGLLIGLTLPGSTRTAAATASEGMFQPFVHVLP
DNTIVVLSKHLDKGQGVATGLATLVADEMDADWAQVRADFAPADAALYKNLFFGAQGTGG
STAIANSFMQYRTAGAAARSMLVQAAAKAWSVPAAEVTVSAGRISHPSGKSASFGEMAGL
AAAEAVPAEPRLKTPQEWVYIGKSFKRVDTARKSAGAAGVYGMDQRFDNMLTAVLARPPR
FGSTVASVDDSAARAIAGVVDVITVPSGVAVLASGTWQAMQGRDALSVTWDDSAAEMRST
AEMEAELRDLTGTPGAAAEGNADAEPLLAGASRVIEADYMFPFLAHAPMEPLDITVLYDG
SSATFWTGSQFQTTDQAVSAAILGLTPDKVAINTLWAGGSFGRRAQPDSHYFAEAALIAK
ARHEAGHAPQPLKIVWTREDDIRGGYYRPMTAHKVKVGLDEAGRITGWLHRIAGKSIMKG
TGFEAFMIKNGIDDTMVEGVHGTTYGIPGFQLEAHMTETPVPVLWWRSVGHTHTAYVMET
MIDRIARETGADPVAFRESLIKEDPRKLGVLRLAAEKAGWDTPLPEGRYRGVAVHTSFSS
YVAEVAEISFREDGTVKVEKVVCAVDCGIPVNPDNIRAQVEGAIGYGLGAVLRNEITFTD
GEVDQSNFDTYLPLRMSDMPVIEVHIVPSEEAPTGIGEPGTPPIGPAVANAIAAARGDYV
TVLPFSKHGLA
>A0A388RGK3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MTTFNINVNGKTRAVDVDPSTPLLWALRDNLDMTGTKFGCGMAACGACTVHINGQATRSC
VTPVSAAAGASITTIEGVDTDKVGRAVLDAWVRHDVAQCGYCQNGQVMSAIGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALASVASVASAA
>A0A388RM71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MSAQPFGRRRFLRATGAVPAALVLGFHLPLAKAGATLALPARDPDDVNAWLRIAGDGSVT
IMVPSAELGQGVMTSAPMLVAEELECDWQQVRAELAPTDPVYNNRMFKVQATASSTSARW
SFEPLRRIGATAREMLREAAAQTWGVPPAECRAVQGSVQHRPTGRVLGYGELASRAAALP
RPASVALKDPRDWKLIGRATNRLDIPPKTCGAAVFGVDVSVPGMLVGSVTACPVFGGKLR
RVDARAAMAVPGVRRVVPLDDAVVVLADSYWSAQKGLKALQPDWQLPPGAPASDDALMAR
YRDAARSAAAVALRNGDPEAAMHGAPVYTAEYEVPYLAHATMEPMNATAHVRADNAEIWG
PTQVCGEIAQRLAPVLGLPAERIRVHSTFVGGGFGRREEFDVFIQAALASKAAGQPVKLI
WSREEDIRHDFYRPAAVAQFSAVLAPGKAGGQPAIRAMEARLACSSIYVRNFPDRVKNGV
DPKSVEGVVDLPYALPDLAVRYAMVNSAVPVGFWRGVGYTQNTFFAESFIDELAHRAGAD
PLQFRLGLLAERPRAATLLRRLAQQAGWGGAPAGCFQGMALSQAWGSLCATVVELSVQHK
RITLHRIVNAIDCGTVINPATVERQLEGASIWGLSAALSGAITIRDGAVQQSNFHDYPLL
AFSQTPRFEAVLVQSGERIGGVGESAVPTLAPALANALFAATGERVRALPLARSGFALA
>F7S946|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidiphilium sp. PM|TrEMBL
MTRKLELHVNGQVHMVEAEPDSMLLYALRDNLGLHGPKFGCGLSECGACTVILNGNAVHS
CVTPLQAAVGQKITTLEGLSSDGKPNKLQQAFIDEQAAQCGYCINGMIMTAQALIDRKPH
ATRDEIKTALEGNLCRCGTHMRILRAVERVTTGHAAQGGTP
>A0A6G8NXU0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Caballeronia sp. SBC1|TrEMBL
MSQGLLDAQNRRAPDGLNRRTFLKLGISVGAAVGGGLMLGFSLPAASQGEAPTAKSVIGG
DGNEAPQSGVFEPNAFVQIDTTGKVTLVIPKVEMGQGIYTSIPMLIAEELEVPLDSVVID
HAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRKAGATARVMLISAAAQQWQVDPASCHA
EKGEVVHAASNRRIGYGQLVDAAAKLPAPQNVPLKDPKDFKLIGTAAKRLDSPEKVDGTA
MFGLDVRVPGMVYAAIVNSPVFGGTLASVDDTNAKKIPGVRQVIRLDNGVAVIGDHTWAA
KRGAAALDIKWNEGRGADFSTAKVVQQLADASKRDGAVARKDGDVKKGFNDAKTRVDSVY
QQPFLAHATMEPVNCTVSVRADGCDIWVGTQVPTRAVDTAVKITGLSADKITVHNHLLGG
GFGRRLETDFIAQALKVGKQVGTPVKVTWTREEDIQHDMYRPYYYDVISAGLDANGRPVA
WQHRIVGSSIMARFAPPAFKNGLDPDAVEVAADLPYDLPNQFIDYVRQEPMDVPTAFWRG
VGPTRGTFVVESFMDELAAQAKVDPVKYRRDLLGKTPRAQNVLDVAAREAGWGNTPPKGQ
GRGVSVMHAFGSFFGMVVDVTVNGDGEVAVNRVVCAVDCGMVVNPNTIEAQIQGGIIFGI
TAALYSEITIKDGRVEQSNFTDYRMLRIDQTPPIQVHIVKSSEAPGGIGEPGTAALAPAL
TNAIFAATGKRLRQLPVGRQLQST
>A0A090WJW3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algibacter lectus|TrEMBL
MKNRIGGKTEAGVFQGLSVYYCHNTHVAEVADITMEDGVPSVKRVTCAVDCGIVVNPFGA
MNQIKGGVLDGIGHAMYADFGFVDGVPKSNNFDSYQMIRMGQTPQVDVYFIESDIDPTGL
GEPTLPPIGAAVANAIYAATGNRINKQPLINNLEPKEKVLG
>A0A6L5BT06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas frederiksbergensis|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQDVRTIDNLHADPVGQIVQQAWLDSAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A1W7M4J7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MSYSLTVNGKQVTVDAGAIDMPLLWVLRDVIGLTGTKFGCGAGLCGACSVLMGGERFFSC
QAPARAFIGQPVTTIEGLRDDPLGKRLQDAWVEADVVQCGYCQPGQLIAAAALLKANPAP
DDEAIEAGMSGNLCRCGTYPRIRKAVKLAAAGGKA
>A0A1N7RXC1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ribeironis|TrEMBL
MTTFNINGQIHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGNRKITTIEAVGTTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLLTSNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGV
>A0A0J9E7U8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Rhodobacter lobularis|TrEMBL
MEFTVNGEKREADVEYDMPLLWVLRDELGLKGTKYGCGVAQCGACTVHVDGVAVRSCQLA
AGEAEGSDITTIEGLGTPETLHAVQEAWVEHQVAQCGYCQSGQIMQAAALLDQDPEPSDE
VIDIVMSGNLCRCGTYPRIRAAVHTAAKKLQEA
>A0A517SN66|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Planctomycetes bacterium SV_7m_r|TrEMBL
MTSIKVNGVVRDLKDVPEDTPLLWALRDELGLTGTKYGCGVNECGACTVHIDGDAVQSCQ
TTVGEVGDSEVTTIEGLSEDGSHPVQQAWKELGVAQCGYCQVGQMMMAAALLKNNHHPTD
EDIEGEMWNICRCGTYPRIRAAVKSAAQKMGQQEAAQ
>A0A330LAH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospira lenta|TrEMBL
MVTLRINGVEKTVDVPDDMPLLWVLRDVLGLTGTKFGCGMAQCGACTVHLDGHPIRSCIM
PVAAVGKKPITTIEAIGQTPVGKKVQKAWQDLEVVQCGYCQSGQIMAATALLKAHPNPSD
SDIDAAMAGIICRCGTYVRIRAAIKQAGQPS
>M5EZC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium metallidurans STM 2683|TrEMBL
MRLTVDGQSFDINADPEMPLLWALRDLMGKTGPKFGCGIAACGACTVHIGGQPVRSCSLP
VGQVSGAVTTIEGIGIEGKLHPVQQAWLEEQVAQCGYCQAGQIMSAVALLDEVADPSDAD
IDNAMGGNLCRCGTYPKIRAAIKKAAVLKTAGL
>A0A840ZZ32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodesianum|TrEMBL
MLKLDTIDAPVPSRRAFLTGAAAGAVLLAFRLDLKGARAAEGSDALSKAPAQPNAFVRIA
ADDTVTVMIKHLDMGQGNTTGLATILADELDADWSQMRVAFAPADAKLYANLLMGPVQGT
GGSTAIANSWFQLRKAGAAARAMLVAAAAEKWGVPAGEITVAKGVISHKSGKQARFGAFA
EAAAAKPVPQEPRLKTPAEWTLIGGRVPRIDSVAKTDGTAIYSLDIRRPGQVTAVVAHPP
RFGATVKAVDAEAAQGMPGVVGIVTIPTGVAVIARDTWSAMKAREALKVTWDDAAAETRS
SDAILAEYRETARTPGLVASQAGDADAGIKGAAKVLEAEFAFPYLAHAAMEPLNATIERA
ADGSYDVYAGCQIQTVEQAVLAATLGVTNDKVRLHTQWAGGSFGRRATPGADYFAEAAAI
VKAWDGKAPVHLVWTREDDMAGGYYRPQVYHTVKAGLDAKGQITGWRHAMVGKSIMIGSP
FEAMLVKNGIDSTTVEGASDTPYALPAYRFEVHNAREGVPVLWWRSVGHTHTAHVMEVFI
DELAHAAGADPVAYRLSLLTRAPRLSGVLRLAAEKSGWSQKPSEKGRGLGVAVHESFGSY
VAMVADVTAGDSTAKVNRIVAAVDVGVAVNPDNVRAQVEGAVGFALSAVLRNRITLKDGV
VQERNFDSYQPTRISEMPQVEVHIVPSDVAPTGIGEPGVPVLAPAIANAVFAATGQRLRS
LPLDLSSLRGA
>A0A7W6F3K5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas pseudosanguinis|TrEMBL
MTSLTVNNQPVRYRLPPDTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGRAVRSCQV
PIGRIEGSVVTTIEGLSRDRSHPVQQAFLAANVSQCGYCIPGMVMAAAALIQKHPDPSEE
LIRAQITNLCRCGIYPRLVEAIQRAARAQRGEETIPGAPLPGTDPADAPRTVPALVPGAM
AQDGR
>A0A7W6A837|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas pseudosanguinis|TrEMBL
MELSRRNILVGGGVGAGLVVAWGLWPRAYAPNLATESGQQAFGAWLKIGRDGIVTVAVPQ
AEHGQGIVTTLAQVVADELGADWRTVAVETAPLSPLYANPVAVDTLFEGAFGRLPAAVRD
EWLRRDMVMLTAGSSSLRMFEEPARAAAATARALMAQAAARRWGVDWTLCEARDGFIVAG
DRRLRFAELAEAAAGETVPQPLPLGSGGAGKLAGKDVPRLDSPAKVDGSANFTADIRLPD
MVHVALRHAPLGHMRGLRIDRDAAMKVTGVVDVIEGEDWVAVAAASWWIAQKGLDALHPR
AITVGPRPTSAGIAQALERALSEEGRLVTSRGDVAGALEGGGLVSASYRVGVGVHAAIEP
RAVVAAWRDDGLELWVPTQAPVRARTVAAQAAGIAADRVVVHPMPIGGGFGIGLETEAVA
QAATIAARLKRPVNLQWSRADDLRRDAFRAPALARMTARLDRGRITGWRSRIATPSTGAG
LAERLMPGGLTRFAMAGQRQGDAYAMGGAVPAYALPALAVHHHPADLSLPTGHVRGGAHV
ANCFFTESFIDELAARSVADRLNWRLGLLRDAPRLAQCLSTAASLGGWEGGGAGSGQGLA
AHRFRDSHIAVMAEAHRDAAGRPVVDRLVAAVDCGRIVHPDIVRQQIEGGLVFGLANLLG
AATGFARGQPQADRLAALNLPRLADMPDITVELIVSDEVPGGVSELAVPPVAPAIANALA
TLGGASRIRSLPMEFPA
>A0A1Y0Y0T6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus subsp. pasteurianus|TrEMBL
MSTHSPSSTARLKTGRRRVLQAGGALLLATLWPTPRGRAAQATQAGTGVLVEGVATPFAP
NAFIRIAADNTITLILPNIEMGQGIYTSSVMLMAEELGIDPFAVQIEAAPPGGGAEITGG
STSVMTEWLPLRQAGAAARTMLVQAAASRWGVAPESCTTANGAVVHAPSGRTVPFGDVAE
AAAKLPVPKEPKLKDAANYTLVGRKHHRLDSQIKVDGTAHFGMDVQVPGMKIGTVAACPV
QGGTVRSMNRNAALAVNGVHAVLVTDNKDTVCVVAEHYWAARKGLKALHIQWDFGKNAAI
TTQTIYDDLHAGLNGPAIVANAKADAPGVIGKAGATYTATYQQPLLAHSPMEPINCTAHV
RPDGCDVWGGTQVAERARDTAAEITGLPASKITVHSQYIGGGFGRRLEHEYVTQCVQFAK
QVPYPLKIVWSREEDITKDRYRPAYVDKLTAALDDKGYITALQHRIVGPAVVARWDPPEL
TKDGYDEDLSLATVVTPYTYPAYRLEFARREAPGITTAWWRGVGGTRGLFVVEGFIDELA
ARAGADPVAYRRAMVQNNPRALAVLERAAADAGWGTPVPKGRARGVALQFAFGSYMASIA
EIEMPSPDEVIIHRVTAAVDCGQVINPDQVIAQIEGGLIFGFSAALYNEITLENGRVQQQ
NFNTWRVMRMNEAPRRIDVVVMPSKEDPGGIGEVGTAAAAPLLANAMAAAQGRRYRSLPL
LSARNTEGKE
>A0A509E439|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassocella blandensis|TrEMBL
MDKNFDASRRKFILGSSAVAFAVLATGAVTVLRNDPAKSRETIEPETLRSIKVDAWVSID
SNNVVTIHFPSTEMGQGIMTSQPMIFAEELDADWSKVIARQIDQGPLETFGNPHTGGILF
TAGSSSIEGYFTKLRMAGANVRRILLYTAATVMGVPVTDLVTEKSEVIHPRSGQRLTYAA
IANAGSMVTNVPAITEADLKPREEWRIIGRDQNRLDIPAKTLGETVYSIDVRVADMVYAT
QALAPVEGETPLQIEDGEARRIKGIIDILPLKNSVAVVATTFEAAIEARNKLQITWSQTS
PFRGVNSQQELADTELAAKDLNLTATAWENRGNAVAALHADAENVVYATYTTEHVYHAQM
EPLCAVANVDEDEKGAEVWLGTQSQTLSIGAAAQALQTTPDRIRFHAMQMGGAFGRRTFF
ARDLLVDAIHISRAVKRPVKLMWTREDDVKNGWLRPATAHHLSATLDKEGRVKAMRHRVA
SPSIFEFAAPQRWANAKGRDLLVMEGTESSEYDIPDFLAEHVLLKRQSRVSAWRGIGWGI
NCYARECFIDELALKAGQNPLDFRRRLLQNSPRSLKLLDEVTQMSDFGNAPNGRAHGLAF
AGYKSTLGAGVAEVSRDPNTGKVKVHKFWAAVDPGIVIHPHNYIAQTEGGIIFGLSGLMR
ERVSFVNGEIEQQNFYDYEVMRIGDVPQIKVNIVESGEAPSGAGEIGVPMTGGAVANAFR
ALTGEHLRHMPFG
>G8T804|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Niastella koreensis (strain DSM 17620 / KACC 11465 / NBRC 106392 / GR20-10)|TrEMBL
MQPKHTIDRRAFLKLSSLTSAALTIGFYFPALAEESSIITAETAENLGIVLNAFISIDKT
GKVSIINHRAEMGQGAFQAVPQMIAEELEVSLDQVSIAFGSGDQTKYGLSQTTGGSSTVR
SAYKHLLRTGATAREMLVEAAAKKWNAPATECYAQNGEVIHSPSGKKLGYGELVEEAAKL
TPPKQVALKERKNYTIIGKPLPRQDTPAKVNGKAEFGLDKKLPGMLYAVVERCPYFLGKV
KSYDDSAVKTMPGVKHVFKVQMPVFDSIREGIAIVADNTWAAMQARKALQVEWDTTGLEH
LDTAALYNRMKEDLNKPGLSQRTGGNFDATYDKAAKKLEAIYETPYEAHACMEPLNCVAD
VQDNKITVWGPIQGPDWIQRDLAERLKIPLENITVNMTFLGGGFGRKAFTDYTTEAVVIS
KEIKAPVQVVWTREDDMTQGPFRPGAVYACKAGMDENGRITAFQTKMAAQNMDHQWPHAN
KSNFNGSTMEGLPEVFINGLEHYSFSDVPTESPIPVMWWRSVYSSTNGFAYESFMDELAH
AAKIDPLDFHRLQLRDERAEALMAMLEEKTGWRTREKNSGWGIAITECFKSMVGEAVKVS
KQADGKLKIDRIVAVMDCGWYVNPDIIKQQVEGSIVMALGAATTHETHFTDGKAVETNFH
QYHMPRIPDVPDIEVYIMENEEKPGGVGEPGLPPFAPALCNAIFDLTGKRIRKLPFNMNE
V
>B1Y1F6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)|TrEMBL
MNTPIESKSPDHVAAETGDTAGPVTLNRRGFMGAGGALVLGFMLPASGRLGAATPTGATL
NAWLRITPDNRITVLCGSAEMGQGVHTAIPMLLAEELDADWKSVRVEQSPVDKAYANPMF
GMQATGGSTTVRAHWTPLRKAGAAARAMLVGAAATQWKVEPSQCRTALGQVLGPKGQKLS
YGALAVAAAKLTPPQDPPLKDRKDFKLLGQPLKRLDTPAKVDGTAKYGIDVNLPGMLVAV
MARAPQPGAKVAKLDDSAAKAVKGVRQVITIPHGVAVLADGYWAARKGRDALKIDWDLGT
LADLSNDKIDAMLSEGAREGGSVAREAGNIKDANATSAKTLDARYSAPYLAHACMEPMNC
TAWVRGDEVEIWAGTQSQGPAQGILSQVAQVTPAKVTVHTMMLGGGFGRRFAPDFTIDAT
LLSKLSGKPVKLIYSREDDMMAGFYRPASVAMFSGALDDQGALTGLAASVSSPSIMAASG
FMKIPDNGVDNFAMEGIADMPYDIENLKLEYGRREPGPQVWFWRSVGHSQNIFFMEGFID
ELAVAAGKDPYEFRRNLLGKQPRYKGVLEAAAQKAGWGQPLPAGVFRGIAVGMSFGSYVA
EVAEVSVAADGTPKVHRVVAAVDCGMTVNPEIIRRQTESGIVFGLSAALYGKLDFKDGRL
QQSNFHDYPVLRMNEAPKVEVHILPSTEAPGGIGEPGTPPLAPAVVNALFAATGQRLRQL
PIDSSKLKRA
>A0A5B8RDA4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured organism|TrEMBL
MQQPYSQPFSPSRRRLLKGAGAAGVGLVIGFHWGLGGPRAMAAETESGGWAPNAFVRIAP
DDTVTVISKHIEFGQGSYTGVATVLAEELDADWSRVQVAPAPANAELYGNALLGGMQGTG
GSTAMASSWDQLRQAGATARAMLVAAAAERWGVPASELSVAQGVVRHAGSGREARFGELA
EAAGRREAPKEVRLKDPSSFRLIGHRVPRVDASEKSNGEAQFTLDIYLPDMLTAVMLRPP
LFGATLRSLDDSEARKVRGVVDVVRTPRGVAVLAEGFWAAKKGRDALKAEWDDSAAEKRG
TEALYEDFAALAREPGATAEAHGDAQAAIDGGTRVIEAEYRFPYLAHAPMEPLDAVIRAT
GDGYELWAGSQIPTIDQGVVAKTLGVPAEKVAVHTQFAGGSFGRRATPNGDVAMEVAGIL
KATDGRRPVKLVWTREDDIQGGRYRPLFVHRLRAALDDDGRPVAWQHRLAGQSIMKEMGG
LRDNGVDPVSVEGAEDLPYSFEHFAVEGHNPEAGVPVLWWRSVGHTHTAFSTETFMDELA
HAAGEDPVAFRLARLGDHDRHRGVLELAADRAGWGKPVPEGRARGVAVHKSFNSYVAQVV
EVSKGENGLPRVHRVVCAVDCGVAINPHNIEAQMQSGIGYGLGAALYDEVVLEDGRPKQA
NFDTYLPTRMTDMPEVEVHIVDSDAAPTGVGEPGTPPVAPAVANAWFALTGERVRRLPFR
RNG
>A0A839ZX00|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phenylobacterium haematophilum|TrEMBL
MNAPVNKKAIAGATRRDVVIGASLVGGALVVGACSPGDILSIGAKEDFGAFGPFIKIAPD
GVVTVVSKHIEFGQGNHAGLAAIVAEELDADWSKVRVEQAPAIAKVYANTGMGVQGTGGS
SAISNSWDQLRKAGASARAMFVEAAANKWSVPAGEIAVKDGVLTHASGKSAGFGELVADA
AKATPPATPVLKDPKTFTLIGTDRVRRKDAQAKSDGTARFTQDVQLPNMLIAMVAHAPKF
GAKVASFDAADAKKVPGVVEVYQIPTGVAVVAENTWAAKQGRDALKVTWNEDEAEKRSSD
AILARYKDLASGKAQPADKEAWQTFESKGDIATVKGEAFEAAYDFPFLAHATMEPMNCVA
QVGGGKAKLTFGSQIPTIDQLNTAKIMTMLPGAVEIETLFAGGSFGRRANFQSDYVAECV
EIAKKVGKDRPVKLVWTREDDMAAGYFRPIAHHTVRVTLDKDGYPASWRQRVVTQTLMKG
SPMGQPKLDETAVEGTLGSPYLKATPIVDAQLIQPDSGVPVLWWRSVGATHTAYVMEHTI
DQLAKKAGKDPVEYRRALYTKAGANRHLAVLNLAAEKAGWTTPTPAGWTRGVAVHESFGS
VVAQVAEVKLDGGVPKVGRVVTAIDCGTAISPDQIASQMEGGTCYGLSAALFGQITLKDG
VVEQGNFDSYRVLRNSEAPTVETYIVPSGNAPSGVGEPGTPVIGPAVANALLTLTGQPTL
SQPFVKA
>A0A3P5WK56|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Xinfangfangia humi|TrEMBL
MTERIKLSRRGFITAVVGAGGALVMGISRPLMAATAGAEPWETPSDGTAFTPWIKIDTAG
KVTVYVTHPDIGNGVITQSCAYVREELECRWEDIRAEYAAPERDHAMGSAYSAVGGALAY
FSGRSTSEPRRTAFMTAAAGARERLKAAAAAAWGVDAGEVAVAEGLLSHAASGRSAPFGE
FVQAASQVVPEAEPAPKTREQWTFLNKVDPAKIQIPEIVTGKAVYGIDVRLPGMVYAALR
QSPVMGGTLVSYDFEAIRNMPGVRAVVEVRPTDPGEPDRIKSPFPMGAAMNGSAIAVIAD
HYWQARTALDALPVVWDDGPGAKWKTTGMIEEAVMAATRQPGGTVELSVGDVEAEFAMGG
TILEAEYMTPYCDQVQMEPLNCTVMVSDSAAEVWTPSQHTQQVFALTVQETGLAPEQVKV
HQTYVGGGFGRRVFGDDSRMAVGVAKGYKGVPVHVIWSREESVRQGRYRSIMGASIKAKL
GDDGLPVAMRTRISGGPGYFTMGIADTVLPLIVPNVQVESQVVSDIHLKVGPLRGPGYNS
TVFFYESIVDEMARAAQEDPLDYRIRLYDRWEDKGWVNILRVLKEKSGWGQPLPAGHARG
VSIGNWGMGGRAHHGTTLGAVVHAEVTSHGEIRVHRIDVAFDTGRVMNRDAVRVQLEGGT
IFGLNLALNEKLNIENGRIVEGNYDEYPVIRMADTPEIHIHFEALTDHDRYDEIGEPPVG
PVGPALANAVFHITGKQMRTQPFREHDLGQGGGV
>H1KPK4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens DSM 13060|TrEMBL
MLKLDLTDAPIPSRRAFLGGAAAGAMLLAFRLDLKGARAAEASDALSKAPAQPNAFVRIA
ADDTVTVMIKHLDMGQGNTTGLTTILADELDADWGQMRVAFAPADAKLYANLLMGPVQGT
GGSTAIANSWFQLRKAGAAARAMLVAAAADKWGVPAGEITVAKGVISHKSGKQARFGEFA
EAAAAKPVPQEPRLKTPAEWTLIGGRVPRIDSAAKTDGTAIYSLDIRRPGQVTALVAHPP
RFGATVKSVDAEAAQGMPGVVGIVTIPTGVAVIARDTWTAMKAREALKITWDDSAAETRS
SDAILAEYRETAKTSGLVASQAGDADGAIKGSAKVLEAEFSFPYLAHAAMEPLNATIERA
ADGSFDVYAGCQIQTIEQAVVAATLGVTTDRVRLHTQWAGGSFGRRATPGADYFAEAAAI
VKAWDGKAPVHLVWTREDDMAAGYYRPQVHHTVKAGLNEKGQITGWRHTMVGKSIMIGSP
FEAMLVKNGIDSTTVEGASDTPYALPAYRFEVHNAREGVPVLWWRSVGHTHTAHVMEVFI
DELAHAAGSDPVAYRLSLLTRAPRLSGVLKLAAEQAGWGGKPSEKGRGLGVAVHESFGSY
VAMVADVTAGESGVKVNRIVAAVDVGIAVNPDVVRAQVEGAVGFALSAVLRNRITLKDGV
VQERNFDSYQPTRISEMPRVDVHIVPSEVAPTGIGEPGVPVLAPAIANAVFAATGQRLRS
LPLDLSSLRGA
>A0A087PMA7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MGKLERIAARQDRAAGRGPTRRGVLLTGLGSAFMFGFAREASAAQTYPQNASLPGNGAFE
PTVWCSVGPDGVVNVNIIRAEMGQHVGTALARIIADEMEADWDKVRITYVDTDPKWGLMV
TGGSWSVWMTWDVFRQAGAAARTVLVEEGAKLLGTSPANCIARNGRVIAGSRSVSFGDIV
SHGRPTRSFSPDEMAKLPLKPASERRLIGKDVKALDIPAKTDGTAIYGIDAKLEGMVYAR
PKLPPTRYGSKVVSVDDSEAKKIKGYIRYIVLNDPSDTVPGWVAVLASTYPAAIRATDAL
KVTWTPGKTANVSEKDIIEHGRKQIAEKTGGSCVFNDDGVDEAFASAKHVFERTYTCASV
LHYQLEPMNALARQQDGKWEIHCGNQWQSLFLPVIAKALQVKETDVVMRSYLLGGGFGRR
LNGDYAVPAALISKELGGKPVKLILTRSDDMQFDSFRSPSIQTVRVAMDDQKALKGWQHH
ASAGWPTGVMASAFMEKGADGKPYDQFAIAGADHWYDVGPMRVRALDNDLADATFRPGWL
RSVSSGWTPWAHEAFLDELAHELGHDPVEFRLSLLTAKGRNAGKAPDSVGGATRQANVLK
RLVEKCGYGKAQLPKDTAIGIATTFGQERAMPTWTAGAVQVHVDRKTGVVTCQKIWLVLD
AGTIVDPDGAMAQTEGGALWGLSMALFENTEIENGNVRDRNLNTYTPLRITDIPEMDIEF
VDSTEKPMGLGEPGVTTIGAAIANGVFNAVGVRLRHQPIRPADVLKGLSEKKSA
>A0A0M9EHL3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shimia sp. SK013|TrEMBL
MSKVGKIARRTFLIGAAAVAGGVAFGVYKVRTPFNNPLENDLADGSATFNPWVIIDSEKV
TLIGPHGDKGQGIAHAQAALIAEELDIEFGQFETSFGKPDKAYWNRAMADDGVPFMFTDK
SFSAESMRTVMGGLLKLLGMQGTGGSSSIPDSFVKLREAGAMARETLKLAASNVSGVPVR
DLKTANGAVLLPDGTEIAYTALAGEAAKLDPVREIKLREPSEWRLIGKPMQRLDIVSKST
GTMDYGIDIDIEGAVHAAVVCNPRQGGALNSYDADTASKMRGVQKIVDVTGGVAVVADNT
WRAIQAAQAIDFDWGPAPYPAEQDDHWAEVAASFVEDRLDKEWRNEGDVDQALAGGKAVD
VEYRVPYVAHAPLEPLNATVLVEDNKVTVWTGHQVPRMLQQQVAAVTGHAPEQVDFYNQF
MGGSFGHRLEFEHVKLAAEVANQMRGTPVKLTYSREEDFAHDFPRHIGMARGSGAVQDGK
VVAVDLAVAMPSVINSQMGRAGLSVPGPDTQISAGAWNNPYSIPNNRMRAYRVPELAPTS
SWRSVGASAGGFFFDSLLDELIYEAGADPLAERIRLMQHDVSRKVLEAVGEMSNWGSTLP
ANTGRGVAFVESFGVPTAEVIEVSNTDNGIRINKVWVAADVGTVVDPVNFENLVQGGVIF
GLGHAMNSEITYSDGMAEQANYWDAEGMRMSQCPEIFVKGLENNPSVRGIGEPPVPPAAP
ALANAIFAATGQRIRELPLYNHIDFV
>A0A1E1UZ09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. BIWAKO-01|TrEMBL
MVSLKVNGRTHSVDVDDDTPLLWAIRDNLGLTGTKFGCGVAQCGACTVFIDGKPLRSCVT
PVSAVGDAEITTIEAISGKEADAVQAAWTARDVPQCGYCQSGQVMSAVALLTENKKPSDR
DIDLAMNGNLCRCATYVRIRAAIHDAARTLEG
>G4MFX3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Paraburkholderia kirkii UZHbot1|TrEMBL
MIVRAQTLLDKTPHPDEAQIRRHMEPNLCRCGTLYAHSRGDPASRGPGRRNEIMKDAPVD
AARRHFLVDGSLMVSFAMIPGAAALAQGTTEAGTFEASAPKLPGSLKNTPMLDAWIKVGA
DGRVSTCTGKAELGTGVRTALLQLVAEELELPPQAITLITADTAATPNEDYTAGSHTMAD
SGTAILNAAAQVRGLLVASAAAQLGVDAATLSTRDGAVVAPDGRRVTYGEAVRNANLHRN
AQPGIPTKPPARYTVIGHALPRVDIPGKVTGGPSYVQDLRLPGMVHARVVRPPGYGATLV
SVDLARVRALPGVIGVVRNGSYLAVVADDEWRAIVAMRELARVAQWKDGQPLPDPGTIHD
TLMRLPAQEIVVVDQHARSADAITTLHARFSRPYMTHGSIGPACAVAHLDDGDMTVWTHT
QGVYPLRKGLAEMLAMPLDKLRCVHVEGSGCYGHNVAADVAADAALIARELPGRPMRVQL
MREQEHLWEPSARR
>A0A840RT59|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Glaciimonas immobilis|TrEMBL
MVSLNINGKETHIDVPADMPLLWALRDVANLTGTKFGCGMGLCGACTVHLDGAAIRSCIT
PISAATGKKITTIEGIDVDHASHVGQAVQAAWRKLDVVQCGYCQSGQIMSAVSLLSQNKR
PTDADIDQAMTGNICRCATYVRIRAAIHEAAKTLA
>A2RW43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia mallei (strain NCTC 10229)|TrEMBL
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
ADIDAAMNDNICRCATYTRIRAAIHEAAATLKA
>A0A6J5FRN2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinitolerans|TrEMBL
MVQIVVNGKRHQFDGDPGMPLLWYLRDELGLTGTKFGCGMALCGACTVHLDGQPTRACVT
PVGSLEGRSITTIEAIHEQKVGAAVQAAWIEKQAPQCGYCQSGQVMSAVALLAAKPNPTD
ADINDAMSGNICRCATYQRIRAAIHHASEELKHA
>K1L656|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MKKPLELQVNGAVKTVEVDPEEPLLYVLREEFSLNGPKFGCGLHQCGSCLVLVDGEASYT
CRIPCASFEGKKIQSIEGLSNGDKLHVLQEAFFEVQAAQCGYCVNGMMIAALELLEGNSN
PKMQEIKSALNRVICRCGTHSRFIKAVKKATSSNSNL
>K1LUK3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MFHPKDLTMLPKFPFLKSKAPENKSKVFVPSRRDFLKMGSLATGGFLLGVNFQCSGPKGE
LITFAPNVYLSIDSDNQVTIIAHRSEMGTGIRTSLPMIVADELGADWSKVKIVQAEGDEE
KYGDQNTDGSYSVRMFYEPMRKAGATARHMLVAAAAKKWNVDASECRTEMGQVVHSGGKK
IKFGDLVDLAQEIEMPDQESIQLKEFSSYKLIGKDIAIYDNLDIATGKAVFGADIDLPGM
QVAVVKRSPVIGAKVRSFNDQKALAVPGVTRVVKIEGAGIPPGLDKALEGVAVIADNTWA
AIKGREALEIEWDLGPNQAYDSEQQLEEMLASTSRNGQIRRERGNFNAARQQGGQVIERT
YLAPFYAHATMEPPAAIAHVHGDGTCEIWAPTQHPQWARQAVAQALDIDYQDVKMNITLL
GGGFGRKSKPDFIVEAALLSKAAKLPVRVQWTRDDDLHHDFYHAQSAQRIRAVLDRNGNL
SGWNHHTVFPAIGATANADEVHPSDGELGLGCIDFPYEVPNIRIETHESKAHTRIGWLRS
VSNIHHAFAISCMLDEVAEAKGVDPVDFLMSMLAEDKNLTFEGELKGDFGNYGEPLDKFP
WNTRRLRGVIEKVAQASNWKQAVADGKNVGFAVHKSFLTYVACVVEVTKADNGQLIIPEV
HYAVDCGIGVNTDRIRSQFEGGAQFATSLVLTSAITLKNGKVQQNNFDGYQIIRMPQAPK
KTHIHLIESMEKPTGVGEPPVPPYIPALCNAIYKLTGERIYRLPYKA
>A0A0C4YC81|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MTTLDINGKPLQVDVDPSTPLLWALRDSLGMTGTKFGCGMAACGACTVHVNGQATRSCVM
PISAAQGARITTIEGVTGDKVGRAVLDAWIKHDVAQCGYCQNGQVMSAVGLLRSKKHPSD
ADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A653LVK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Maribacter litoralis|TrEMBL
MAIFNLNINGSEHSVDVDSNTPMLWVLRDHIKLVGTKYGCGIAQCGACTVHLGDNAVRSC
QLPVSAVGEQKITTIEGLSEHGEHPVQKAWLEIDVPQCGYCQAGQIMSASALLKRNPNPS
DEEIESAMNGNICRCGTYTRIKKAIKTAASSENV
>A0A3G8C4L8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R4-34-07|TrEMBL
MKTSEILPGVTLDAPINLSRRRFLASTAVGALVIGFGLPLGASRVQAATGNAAERGTQVP
AFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIIGEELDADPATFVVEAAPPGEAYVVMENG
LRITGGSMSVRMSYPTMRRLGALARAMLMQAGAEQLGVPLAQLTTQPGRVVHAASGRSLG
YGELAGRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYSIDLKVDGMLH
AAVQHAPRLGMTVGSLRNQAQVEAMKGVHSVHTLPGAVAVVAERWWHAKRAVEAIQVDWL
EAAADSTVRAMPADFSSDKYRDFLAAQQGPARDDENEGDVAATLANAKTRVDATYHNQYL
NHAQLEPPSALARYNPDGTLEVWLPNQAPDMFRADIAKRTGLAVEQITLHSPLLGGFFGR
HFLYDSANPYPQAIALAKAVGRPIKLIWSREEEFVRDVLRPVAVVKFRAALDEKGLPVAI
EAVSATEGPTEAIAGKQGDALDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGN
SLNDFFYEAFLDELADKGGHDPYELRLHLLRDNARLTTLLQAVGELSGGWKRGPFTAEDG
SRRARGVAMASPFGSHAAVIAEVSIDNGQVKVHDIWQAIDPGSIVNPAIIEAQVNGAVAL
GLSQTLLEEAVYVDGKPRARNYDLYPILPPSRMARVHVKIVESGEKMGGIGEPPLPAVAP
AVANAVAQLTGQRIRSLPLSRYTFS
>A0A7X0UD57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MQLTINGKTHPVPAGWEQEPLLWILRETAGLVGTRFGCGVGLCGACTVLVDGEAARACLL
TAEALQGRAITTIEGLAAADGTLHPVQQAWVAHNVPQCGYCQSGQIMGAVALLRATPRPD
DAQIDAAMAGHLCRCGTQRRIRAAIHHAAGNTGGGTPA
>A0A3G7UNN0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MTETTLSREQWLAKAGVLLIVDDVLPPSGPVAKGGTPAVKPKELGLFIAVNDDGLVYAFN
GHVDLGTGVRTALAQIVAEELDLGMDQVRMVLGDTARAPNQGATIASATLQICAVPLRNA
AAEARRFLLARAAGRWGVGTASLKVEAGVIHAADGRTTTYSELVSGQHDQVRISGSAPLK
ALADYRLVGQDTARVDIPGKATGELTYVHDMRVPGMLHGRVVRPPYAGLDCGEFVGNSLL
SVDEASIAHIPGIVAVVAIRDFVGVVALREEQAIKAAAELQVQWKPWAHAAPDMRDVAQA
IRANPRVRRTVLDQGEVDAALANASQRMPRTYLWPYQMHASIGPSCAVADYQDSGSRVWS
GSQNPHLLRADLAWLLECDEALIEVIRMEAAGCYGRNCADDVCADALLLSRAVGKPVRVQ
LTREQEHLWEPKGTAQLMEVDGGVNADGSIAAYDFETSYPSNGAPTLALLLTGRVEPVAA
MFEMGDRTSIPPYDIDNMRVTINDMAPIVRASWMRGVSALPNTFAHESYIDELAFAAGVD
PVEYRLRYLKDPRAIDLVKSTAERAAWSPRTAPMQTASDDHLLRGRGFAYARYIHSKFPG
FGAAWAAWVADVAIDKHTGDVSVTRVVIGHDAGMMINPAGVEHQIHGNVIQSTSRVLKER
VTFEESTVASKEWGGYPILTFPEVPKIDVLMMPRQDQPPMGAGESASVPSAAAIANAIYD
ATGIRFRELPITPERVLAALKAGTLAEPPKSPQKRRKWWFGALFATLGALLATAWPLHSE
IAPIAPPSPGTWSKATLERGRLLAAVGDCAVCHTAPGGAPNAGGLAMQTPFGTLYSSNIT
PDVNTGIGAWSYPAFERAMRDGIGRDGRNLYPAFPYTAFRNINEADMQALYAYLMSQAPV
SRAATPNAMKFPFNFRPLMAGWNALNLRRGEITPQPERSEQWNRGNYLVNGLGHCAACHS
PRNLMGAEKGGKAFLAGGVVDGWDAPALTGLSKAPTPWTEDQLFTYLSTGYSDAHGVAAG
PMGPVVSELSKLPKADIRAMAVYLASLNHEAAAQAQVAAAPVPNPNGRRIFEGSCKACHA
DGLGPKLFGVSPSLATNTNVFSDQPDNLIKVILQGIAQPATRDLGYMPGFRDSLSNTQVA
DLVAYLRGRFAPNAPQWQGLEQKVAHLRANPGSH
>I2GGJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrisoma limi BUZ 3|TrEMBL
MMKINVTINDVASAFDVDPDMPLLWLIRDEAKLKGTKFGCGMAQCGACSAHVDGELVRTC
SYPVHLAHEKKITTIEGLSANPNHLHPIQQAWLEVQVPQCGYCQSGFMMAAAHLLEENSN
PTEEDIKNGITNICRCGTHPRIIKAILLAAKLKNNGTTN
>I2GGK0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrisoma limi BUZ 3|TrEMBL
MAQPTDKPKKGFSRRKFLARSGATIAGSLALLYFGRSNIRSGISQLAADVKFDAGITDFD
PMLWFEVNEDNTITLRSPKIEMGQGVFTGFAMLAAEELDLPIDNIKVVHASTSTGPQSTA
ATGLSNSTASLYTPIREVAATLRETLKLAASKAWGVPISGIQTANGVLTAGSRRASYAEI
AGQTQTWEIAKTPALRPASSFKIIGKAQKRIDLPEKIMGEAVYGIDTDIPGMLYGAVLYC
PYVGGVLKTADTTLARTNPAVLSVVQDKNWIGVVAKTRFAAEKAIAGIKATWDFEPNYST
KDAIEAITVGNGVTVVMEDEGNATDALNSDVLTSEYRTPMGFHASMEPSIVVADVSGETV
KLYTSTQNVAFIQQSIADQTHFKPENSQIMPAFLGGGFGRRAFKHNAIEAIKLSEAAGKP
VHLLSTRQQEFQNGHVRPNTHHRLNGKVDAKGKIQAIQHEFATGSMAFLGMPVAKPLLGA
DFMAAGHGGRVPYAIPNKKTSIWSSDLPFQTGLWRGVGMFANTFAIESFIDELAIKAGAD
PLTFRMAHCGNTALLQRRKKLLQKLGEQGGWRKPKTDTIGRGIAVCEDHDTISGAIVELE
IVEKKIKILRVVQAIDAGLLVNPDGVRQQVEGATMMAISASLYEEATIENSQFVQTNFHN
YQVAKLKDTPQIDVLIRESTEMPSGVGEPPLSPVAPAIANALYNLTGIRLRSLPLQAALD
SYYQETGS
>A0A1U7D988|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MTVTLSRRRFLASATAGAFVIGAAPNGALAFGAPPKVAGFTPFIRIDSDNRITVIVKHFE
MGQGTSTGLPALVAEELNADLGAIIVEFAPVDPAYNNLLMGAQLTGGSTAMANSYMQYRK
AAAAARDVLLEAAAQEWGVAAQGLALDDGTIRGAGRSGEIGEFVEAAARLDLPQEPVLKD
PSQFRLIGNASARRKDTPSKVNGSAKFGMDVQLADQIIAVMIRPPRLGARLTSFDASGAE
AVRGFIGARPRDGGNGVVVLAEDTWAAFQARAAITTEWDFSGTDGRSQDAIRADMLNKVR
TTPEFEARADKPRHEVAATIDGAANMVEGEYFFPSLAHAPMEPINCTVEPDGKGGVVLHD
GCQFPTQAQALVAATLGLDPAKVAIKTYYAGGSFGRRANTDADYQVEAAEAFQLSGGDRP
VKLVHSREDDITGGYYRPAFAHRVQVGLDAEGRIVGWDHQLAGQSIIKGTPFEEALAQGG
VDALSVEGVRDTGYAVGDMFVGLTDEEPLSKVLWWRSVGHSHTAYAMETMMDKAARAVGA
DPVAFRLRHLAGDGADQKRLSGVLKAAAEASGWDTPAPEGRARGVAVHKSFNSYVAEVVE
VSQANGAIRIEKVTCAVDCGVAVNPDIIRAQMESGIGYGLGHVMRDAITFADGAVEQRNF
PDYEPLRVSDIGEIDVVIVPSEEAPTGVGEPAVPPSGPALANAIAALMPDASLSALPLEA
HGIRFA
>A0A0P1ERN0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shimia marina|TrEMBL
MGKVGKIARRSFLIGAAAVAGGVAFGVYKVRTPYENPLKNDLADGAATFNPWVVIDGNGI
TLITPHGDKGQGVAHAQAALIAEELDVEFGQFQIDFGKPDKAYWNRALAADGAPFMATDE
SFAAEATRGVMGGMMKLLGMQLTGGSTAMPDSFDKLREAGAVARETLKLAASTKTGVPVA
QLKTAQGAVILPDGSTLAYTDLAAEAAELEPVTDIRLRAPAQWRLIGKPMNRIDMVAKST
GTLAYGIDVDIDGMVHAAVMCNPRQGGALLSYDAGAAKGMRGVQEVVEVTGGVAVIADNT
WRAIQAVQAIDAEWGEAPYPAEQEDHWAALEASFNETHLDKEWRNEGDVSAALASGKAVE
AEYRVPYVAHAPLEPLNATVLVEDDKVTVWTGHQIPRMLQDLVAKITGHSAAQVDLVNHF
MGGSFGHRLEFKHVELAAEIANQMRGTPVKLTYSREEDFAHDYPRHIGMARGSGAVKDGK
VIAMDLEVATPSVVASQMGRAGVTVPGPDMQIAAGAWNNPYGLENFRMRAYRAPELAPVS
SWRSVGASAGGFFFDSLLDELIHEAGADPLEERIRLMQHDVSRKVLEAVGEMSNWGSPLG
PNKGRGVAFVESFGVPTAEVIEVTNTEDGITIDKVWVAADVGTVIDPVNFENLVQGGVVF
ALGHAMNSEITYSDGMAEQANYWDAEGMRMMQCPEIMVRGLENGSAVRGVGEPPIPPAAP
ALANAIFAATGQRIRELPLYHHVDFV
>A0A6A7SF36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|wastewater metagenome|TrEMBL
MSITLKVNGKTHSVDVDADTPLLWVLRDELRLTGTKYGCGISQCGACTVHLDGSPTRSCV
LPVQSVGDRSVTTIEGLESPAAAAVQKAWAEMDVPQCGYCQSGQVMSAVGLLEQTPQPDD
DAIDGAMRGNVCRCATYQRIRAAIHRAAGELEA
>A0A220W8E6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus sp. SMR4y|TrEMBL
MGKWTRRAFIGAGVAAGGALVVGIAVRPGDPSDELKASIAGGEGEQLLNSWVKIAPDNRI
TAIVPHAEMGQGTHSVLAQMLADELDADWDTVAVLEAPGVRTYASADIVRDFLTPKLEVP
AILEPTAQGGFLALADMLSLTITGGSFSIRGVGQRSIRTAGAAAREMLIAAAAETWGVPA
EEITTANSMVNHAPSNRSATYGALAEAAAKQPVPAKPQRKTVSEFKLMGQPMPRKDIPSK
VDGTASFGIDVDIEGMKYAAVKAPPVLGASVTSMDASTAKAMPGVLQILNMGDFVAVIAD
GYWQAQQALNTIDTTYSEAEGQELDSDAIFARYAQAMDDAGSDGGDIEIEEGDAVSALAD
AAKTVKADYRVPFLAHATMEPMNCAARIAGGRCDLWLGTQNPIGVRRDVAAALGMDADDV
HVENQYLGGGFGRRSITDVPIMAARLAKAAGYPVKMIWSREEDVAQDLFRPSASTRFAAG
FDAAGNLDSWTNIHVHSFDPKEAAKIKHYAIPNKLIRKVDAPTHLRFGPWRSVDQSHQGW
FIESFVDELADAAGKDPLAFRQTLLAGEARHLAVLNKAADMANWGSPMPDGHGRGIAFIP
SFNSVVAQVAEVDMTGAKPRVTKVYCCADVGFAMNPDAVIAQMESAIAYGLTAALYGEIT
VRDGAVQQSNFHDYNMLRINETPEIEVALINGDHDRIGGAGEPGLPPIAPAVTNAIFAAT
GKRLRELPIAKHDFA
>A0A7W9B0U2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Brucella daejeonensis|TrEMBL
MNEISRDQNIESVLSNGEPVPNGAPVNVSRRHFLLGSMGLTAGALVLGFGLPVGPARAQK
AAAKIVPGTRVPAFLEIRPDNTVRLLSPFVEGGQGVFTAMAQIVGEELDMDPQSFVVENA
PPGPDYLVIGGKMRITGGSMSVRSSYDTMRRLGAVTRAMMIEAGAKQLGVPADQLTTEPG
QVVHAASGRKIAYGDLAREAMELEAPAPDSIKLRDPGQFRWIGKAVQRVDVADKSTGRAV
YSIDMKVDGMLHAAVQHAPRLGMSVGGIRNEDAVKAMKGVHSVHRLPGAVAVVAERWWNA
RKAVEALEVDWSEAGDKPAIEGVRVMPADFSTVAFRERLANEPGDGKNAEKEGDVAGAIA
AAKTQVSATYYSQYLRHAQLEPPSALARFNDDGSLDVWLPNQAPEMFHADIAKLTGLDPE
KVNLHSPILGGFFGRHFLYKAASPYPQAIQLAKAVGRPVKMIWSREEEFLRDPMRPMAAV
RFRGALDENGTPVALEAVSVCEGPSENGSGHNPDKLDPMALEGLTDKAYAIPNRRIAQLY
VENPAILAYWRSVGNSMNDFLFEAFLDELADKGGKDPYELRMQLLKGNDRLTNLLKAVGD
LSGGWKRGPFNAEDGRRRARGVAMASPFGSHTAAIAEVSIQDGEVVVHDVWQVIDPGSIV
NPAIIEAQINSATALGLSQVLMEEAVFEKGEPLARNYDQYSILPPDKMPRVHVRIIESGA
KMGGIGEPGLPAVPPAVANAVSILSGQRIRSMPLSQYKFEG
>A0A840ZNJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodinum|TrEMBL
MIQDFFSKTSAKLTDERAASKDAAGPVIIDNFSRRGVLGGMGALVLALSLSDKAKADEGQ
TEEQKAKKFGADGMPNGWRDDPKIFVAIAKDGTVTVTNHRSEMGTGVRTSIAFTVADELE
ADWSKVKVVQAWGDEQRFGNQDTDGSRSLRHFFQHFRHVGAAAKLMLIQAAAKQWGVPVG
EVTAENHVITHAKSGRKLGYGDVAEAAASLPVPARESVSLKKPEAFRYIGKGKVGLIDNH
DITTGKAIYALDVKLDGMLYAVVARPAVYGGKVKSFDDTEAKKVPGVVKIVKIEGGEIPS
EFMPLGGIAVIAKNTWAAMKGREALKITWDDGPNAGYDTDAFRKELEAAARKPGKVVRTS
GDVDAAMKTAKTKIEAEYFVPHLVQAPMENPAAVARVKDGACEAWACTQGPQAAHDRLMK
RLNLPADKVRVNVTLLGGGFGRKSKPDYVVEAALCSQAVDGAPVKLVWTREDDIQHSYYH
TISVERIEAGLDDKGMPVAWLHRSVAPTIGSIFAPDPKHELPFELGMGLVNNPFDLKNIR
LENPEAAAHTRIGWFRSVSNIPHAFAIQSFVAELAHAAGRDPKDYLLDLIGPARKIDPTE
IGDVWNYGEDPKRYPVDTGRLRNVIETVAKGAGWGRKLEKGRGLGIAGHYSFVTYTAVAA
EVEVDAKGQVKVHAVDIAVDCGPQVNPERIRSQMEGAVIMGMGLALTSKITFKNGRTEQT
NYDTYEITRIDAAPKVVRVHLVPTGTFDGPLGGVGEPGVPPVAPAIANAVFAATGRRVRE
LPLRDQLSS
>A0A160VH46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MAITWDGGPNKAVDSKTIYEYLQKRGRKRGATGRRDGNAKRALNKADTVIEAVYELPFQA
HATMEPMNCVVDVQSDLCRIWAPTQAPQQARKRASDITGLSMDNVEVNVTFLGGGFGRRA
FNDFIDDGLAVSKHMGKPVKLIWKREDDMRHDYYRPASRHVLRGGLTKNTNTTAWTHRVV
APSIIFGQMFKYPIPFKDKLDVVALEGAKNLPYEIPNIHVDYKSANTAVPIGWWRSVYNS
QNAYANECFMDELAYAANMDPLQYRLQLLPDDSRNSNVLKLAAKKASWGESTPTGRYKGL
SCHESFGSYVAQVAEVSIGEDNIVTVHRVVCVIDCGQTVNPSIVEAQMESSIVYGLSATL
RGEITIEKGAVVQSNFHEFEVLRMDEMPEIDVHIIKSTATPGGVGEPGLPPVAPAVANGV
FAATGIRVRKLPIKPEDLRS
>A0A7X0E9J6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. A1T4|TrEMBL
MLSLSVNGESHSVDVPADMPLLWVLRDVIGLMGTKFGCGIAQCGACTVHLDGQPVRACVL
PVGSIGSKAITTIEAIGDTPSGQKVQQAWLDVDVVQCGYCQSGQIMSAAALLKRSPNPSD
AEIDAAMSGNICRCGTYVRIRAAIKQAATGKLEILQTIVTSPEGAAS
>E6XAU0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cellulophaga algicola (strain DSM 14237 / IC166 / ACAM 630)|TrEMBL
MSIVKNRYFYTQCLAYLVQIKFGPNKKYMVTLKINGKEHQVDADSEMPLLWVIRDIIGFT
GTKFGCGKGLCGACMVLMDGAAINSCQLPVSLAVGKELITVEGDQENLQRLQESWEEFNV
PQCGFCQSGQLITATALLNSKANPTEQDINTAMSRNICRCGTYPRIKKAITNSVALKNKE
>A0A841MYD5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MKTASTKINRRSFLKVSALTGGGMLLSLNWLAACQPKEANALGMPKEWFQFNGFIKIGEN
GLVTIMSPNPEGGQNVKTSMPMIVAEELDVDWENVLVEQADLDTKYFTRQFIGGSQAIRS
GFTNLRTAGATARAMLVAAAAQSWNVPANEITVKTGIISHKGSGKSANFGEFASLAATMP
VPEEVPLKSAGDFKIIGTSKKNVESKNIVTGKPLFGIDTKREGMLIAMIVHPPAFGKTLK
SFDDSKARNMPGITDILQIKSIQDDYKKTFFDTVQFTDLIAVVGESTWQVLQAKKAIKAE
WEIQEAYEEKRDMLGREGIRVVPKGLESMASQEQAMMVAAQKPQTQRKDGDPEAAFAQAA
KVIERSYTGPFLAHNCMEPMNFFAHVKGDRVECAGPLQKPELTEQALSSRLGIPLENIEI
AMTRLGGGYGRRSYAHWLIEAAVISQKMNAPIKLIYTREDDMTGGVYRSRYQATYRAALD
ENNQMIAFHVNAGGLPENPLYPDRFPAGAVANYLAEGWEVPSNITTGSFRAPRSNFMACV
EQSFLDEVAEAAGKDPIDFRLELLADAKANPVGERNDYDAERYAKVLELLREKANWGSSK
DGISRGVSAYFCHNSYAAQVLDLKIVDGEVKIDKVTNAIDCGLVVNPDAAKNLCEGAVVD
GIGTAMYGELKFENGVVNNSNFHQYRQIRMKESPDSIETYFVENGEDPSGLGEPAYPPVF
AALANALYQATGKRFYDQPFINQLNS
>A0A841MJE8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MTLIDKKLNRRSFLKVSTLAGGGMMLSFSWLAGCKPTAEEVLTMPDEWFTINSYIKIGEN
GAVTLFNPNPEFGQNVKTSLPMILADELDVDWKNVFVEQADFYPERFERQFTGGSNSVRS
SWKPLRTAGATARHMLINAAAQTWNVPAGEIITSTGMLEHKSSGKKAGYGELASLAGTLE
APDPEAVKLKENADFKIIGNSKKNVDGAKIVTGKPLFALDHKVEGMKYAAIVHPPAFGMK
LKSFDKSSVTSLPGIQDAFEVKVFKDDYGRNFFDTTTFPEIIAIVGNSTWEVMQAKKKLN
VEWEKAPDSTFPMAGRGGQNMDIKVPGGLENSAAHKEKMAEYITKPGNVQRKDGDPEGAF
KKAARVLERTYTAPFLAHNTMEPMNAFADVKGDKAVIYGPTQAPESIMNALSSSLGLPKE
NIQINLARMGGGFGRRAYSHHLVEAALISQKIQAPVKMVYSREDDMSAGVYRPTYSATYR
AALDENNNLLALHIKAGGIPESPLHANRFPAGAIDNYLAEGWQIESNITIGAFRAPRSNF
IAGAEQSFLDELAEEMGKDPIEFRLELLKRAETNPVGERNDYDPKRYAGVLELVREKSNW
SAVPNGISRGVSAYFCHNSYVAEVIDVSIKDNQPVVENVFAAVDCGIVVNPDAAANMGEG
AIVDGIGNAFYGEMAFENGVPTKTNFDKYRMIRHSEAPKKIEVHFVESTEDPTGLGEPLF
PPVFAALGNSLYKATGKRLYDQPFQPQIMQMENLRM
>A0A109D224|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. WDL1|TrEMBL
MSMDIAPSIESTPLSRRQFLIRSSTVSCSVAFALTGAARTAVAAATQDAATTGKISPNIW
VNIHEDGVIEIVCPAVELGQGAHTALPRFVAEEMDADWGAVRVLQASANDKLYGNPLAWN
TQITAASRTTNGYFDVLRVAGAQARYILLHTAAGKWRVPFAELSSRKSVVLHAKSGRRIT
YGELVGSIQMPASLPHFFAPGEAPQPADDYFGEAPLSIVAPDPKRKDSIRLKRKYQYQLI
GVDTPRPDIPDKTTGKASYGMDVQLPGMLHAMVETGPVFGMAPEEVDEAQALQVPGIVRV
LRLPYGVAVVGDNLIAVRIARRKLQVQWAPLPEKQGYGSDAVLQEFSELARETKGTAVRA
WSQGDASATESALAAGARSSVERFEMTSDLVYQSPIEPQNATIRPSADGKSAEAWVGTQW
PTVEQGFAASILGIPPDQLKMHLPYVGGGFGRRLEPGAMVDAAHIVRAVGKTVKVLWTRE
DDIKRNPFRQALACRIEAAVDEKSGQISAMRHTVVADSWLARLFPQYFGAYQQTDPGNWI
GGRVAYDIPLQVIDAVTPRRSVDVCYMRGIGVAQVKFAQESLMDRLANQRKVDPIEFRVR
HLKKEPRAVAVLNEVARMSNWRRRRQTLSDRSTALGVAYTPYSNAHVALVSEVSLNSQTG
EIRVLRVWCALDIGLVAQPDIVKSQMEGGIVQGLSVALMERVTVERGVVQQTNFHNYPIL
RMSQMPDIAVTILATEHPMTGVAELGLLQIAPAINNAVAHLTGTHLTRLPMLPAQVLAAI
KSP
>A0A7W6AHS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium brachythecii|TrEMBL
MLKIARPSATPSRRAFLAGGAAGAILIGFRLDLRNPAHAAAGPDLSKVPAQPNAFVRIAA
DDTVTVMIKHLDMGQGNTTGLATILADELDADWAQVRTAFAPADAALYNNLLMGPVQGTG
GSTAIANSWFQLRKAGAAARAMLVTAASSQWTVPASEITVAKGVVRHAASNREARFGQLA
ESAASLPVPQEPRLKDPSAWTLIGKKGHRLDSIAKTDGSAIYSLDIRRPGQVTALVAHPP
RFGATVKRVDDAAAKAVPGVVAVVKIPSGVAVIARDTWTAKKAREALKVEWDDSAAESRS
SDKILAEYREIAKKPGLVASQAGDADAAIKGSAKVLEAEFSFPYLAHAAMEPLNCTIERA
SDGTFDVYAGCQLQTVEQAVVAATLGVTPNKVRLHTQWAGGSFGRRATPGADYFAEAASI
VAAWDGKAPVHLVWTREDDMAGGYYRPTVYHTIKAGIDAKGAVTGWRHTIVGKSIMIGSP
FEAMIVKNGIDATTVEGASDTPYQIPAYRFDVHNGREGVPVLWWRSVGHTHTAHAMEVFI
DELAHAAGADPVAYRLGLLGRAPRLSAVLKLAAKEAGWDRKPTEKGRGYGVAVHESFGSY
VAMVADVTAGDSSVKVNRIVAAVDVGVPVNPDVIRAQVEGAVGFALSAVLRNRITLKDGV
VQETNFDSYQPTRMPEMPQVEVHIMPSSEAPTGIGEPGVPVLAPAISNAVFSATGQRLRS
LPLDLAGLKGA
>A0A143GH48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas yamanorum|TrEMBL
MTMTDAIPSRDQWLAKAGVLLIVDDVLPPSGPVAKGGSPTIKPKELGLFIAVSDDGLVYA
FNGHVDLGTGIRTSLAQIVAEELDLTMEQVRMVLGDTERAPNQGATIASATLQISAIPLR
NAAAEARRFLLMRAAQRWSVSAQSLTVDAGVITAEDGRTTTYGELVMGEHDELRISGDAP
LKATVDYRLVGKGAARVDIPGKATGELTYVHDMRVPDMLHGRVIRPPYAGLDCGDFVGNS
LLNVDESSIAHIPGIVAVVVIRDFVGVVALREEQAIKAAQELRVHWKPWNNQLPDMSDVE
QAIRDNPRVRRTVLDQGNVDEALAAASQRMPRTYLWPYQMHGSIGPSCGVADYQPGVSRV
WSGSQNPHLLRADLAWLLECAEESIDVIRMEAAGCYGRNCADDVCADALLLSRAVGKPVR
VQLTREQEHQWEPKGTAQLMEVDGGLNADGSIAAYDFETSYPSNGAPTLALLLTGRVEPV
AAMFEMGDRTSIPPYDIENMRITINDMAPIVRASWMRGVSALPNTFAHESYIDELAFAAG
VDPVEYRLRYLKDERAIDLVKSTAERANWAPRTAPMQTANEDHLLRGRGFAYARYIHSKF
PGFGAAWAAWVADVAIDKQTGDVSVTRVVIGHDSGMMINPAGVQHQIHGNVIQSTSRVLK
ERVTFEESTVASKEWGGYPILTFPEVPQIDVLMMPRQDQPPMGAGESASVPSAAAIANAI
YDATGIRFRELPITPERVLAALNAGTLGEPAKSPEKRRKWLFGSLFAAFGAVLGMAATAW
PFHSEIAPIAPPSAGTWSKATLERGRLLAAVGDCAVCHTAPGGATNAGGLAMHTPFGTLY
SSNITPDEKTGIGSWSYPAFERAMRDGIGRDGRNLYPAFPYTAFRNINDADMQALYAYLM
SQAPVRQAPVPNAMKFPFNIRPLMAGWNALFLRRGEISVQPQRSEQWNRGAYLVNGLGHC
AACHSPRNLMGAEKGGKAFLAGGRVDGWEAPALNGLSKAPTPWTEDQLFTYLSTGYSDAH
GVATGPMGPVVTELAKLPKTDIRAIAVYLASLNDSGAAEAQVVAAVTVPNANGRRVFEGS
CKACHADGQGPKLFGVSPSLATNTNVHSDQPDNLIKVILQGISTPATRDLGYMPGFKDSL
SNTQVAELASYLRTRFAPNAPQWEGLEQKVAHLRANPGTH
>A0A839U8E8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MGEKPGLSRRAFVFGSVAIAGGVAFGQYGQAQPALSSAVAPNPLTADLGPNSVTFNPWVE
ISPEKITLIAQHADKGQGVGSIQALMIAEELDLEPGQFEIHFAGPSPVYFNTGFAHELAP
FMAADQSPEAEKARAAALEWLRKAGLQMTGGSSAIPDTFEKLRMAGAIARETLKAAAAKR
SGLAAADLRTEAGSVILPDGTKIPYVALSADAAKITPVAVAKLREPSQWRFIGKPMERLD
IRSKVTGEMKFGIDRTMDGMVYAAVKLNPNKGQPIKSYDASKAQSMPGVQTILKISNGIA
VIATNSWYAMQAAEVVDCVWEPSIYPAEQADHWNVVASSFAPQFLGKEWRNDGKIDAGLK
DGTLVEAEYRAPYVGHQPLEPLNGIGIVTGKGMEIWVGHQTPQSVQYIAATAIGMKPEQV
TFHNEWMGGSFGHRLEFENIRALAEIANQMRGIPVKLIFSRKEDFLQDIPRQIAMGRCRG
SVKDGKIVAADLQVAATAPFKELLARMGAPTKDPDGQLAVGIWNVYYNIPNYRATSFEVQ
GLSPSTTWRSVGASANGFFTESFIDELIYAAGLDPLGARIEMCKIPIYRKLLETVGEMAD
WKGPLGSGKGRGVAFVESFGTAVAEIVEVTMTGAGIKIDQVWVAADVGKIIDPVNFENLV
QGGVVWGLGHAMNCELTYAKGAVQQTNYNRHEAMRMYQCPVIEVRGLENDYTVRGIGEPP
VPPAAPALANAIFAATGKRIREMPFNKFIDFV
>A0A1Y5TR05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseisalinus antarcticus|TrEMBL
MGTLRKVGRRAFLIGSAAIAGGVAFGTFMVARPHANPLEDGLAEDEATFNPWVKISADRI
TLITPHADIGQGVVHMQATLIAEELDLDHGQFLTEYGPPSPAYYNHAFAAEGAPFLSTDT
SLGAETARAALGAFVKVTGLQGTGGSTSTPDSFDKLRQAGAVARETLKLAAAEVSGIAVN
ELKTESGAVVLPDGTRLPYTDLAATAATLDPVQQVTLRSPDRWRLIGKPSERRDVVAKST
GRQLYGIDLEVPGMVHATVRTNPRRAAMLGYDASAARDMPGVRDIIEITNGIAVLADNTW
RAFQAARAVEIDWAPAPYPPEQADHWAEVARSFTEDRLDRLWRDIGDAGAALSAAEVIEA
EYRTPYVAHQPLEPLNAIVRVTDDGAEVWTGHQTPGFLQQVVADVTGHEPDAVVFHNQHS
GGSFGHRLELDFVRQAAEIATRLSGTPIKMTYAREEDFVQDFPRHIGMARGRGAIRDGQV
RTIDIQVAAVSALRSQFRRLGQPSPGPDLQIPAGVWNAPYGNLSDFRVRAYAVPELAPTS
SWRSVGASSGGFYIESFLDELIRAAGADPIDERLRLIDSPVAAEVLRTVAEMSDWGAPLG
EGKGRGVALVESFGVPVAEVVEVTNTPDGIRVDKVWVAADAGMIVDPVNTENQIQGGVVW
GLGHAINSEVTYSDGIAQQTNYHAAEGMRLYQTPQIEVRTLTNNRTVRGIGEPPVPPAAP
ALANAIFDATGQRLREMPFHNFIRFV
>A0A2Z4UNN0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobiaceae bacterium|TrEMBL
MKPTRRQLLIGGTVVGGGMLLGYATLGSSRPERAQAFAAGEGEHFTTTWLKIDPDNKVTV
YVPHSEMGQGVHTSMPMMAAEEMEADWDLVQMVQAPADDVWANGPLAKGYIVGQTPIPSA
LTGVVDASFFKIAEMMVGQITGGSTSVRFTGQYGMRVAGAAAKEMLIRAAADKWNVPESE
LTARLSHVHHDASGKSATFGELAAAAAEYSPPKSPTLKDRKDFTIIGTSKPRYDIPSKVN
GTAQYGVDVQRPDLKIAAIRQAPVFGGSVKSFDGSAALNQRGVSAVVSTDDGVAVVADNY
WRAKQALELVEVEFDDGGNGSVSTESIFATFHDNLENAESEEDVEIGDAVAAMAEGGDLI
EARYEVPFLAHTCMEPMNCTIEFKDDKVEVWVGTQDGLSTRNVVAEVAGVAPENVHVNNF
MLGGGFGRRGPSASNHVHQATKIAKQVGGPVKLVWSREEDVQHDYYRPAVAAHMSATLND
KGEPTAWVNRYIRKDEPAEASHIPYAVANQSIRYVESPVHVPYGAWRSVAHTQHSFFNES
FVDELANAAGKDPFEFRMSLIGDNPRHKAVLAKAGEAAGWGTPLPVGHARGVALQQSFDT
IVAQIVEVSIDDAGEPKVHKVSCAVDCGPVVNPDGAAAQIESGVIYGLTAALYGDITIED
GAVVQENFPDYDAVRLAQTPEIDIHFMESDAPFGGLGEPGTPCIAPAVANALFTLTGQRV
RSLPLMNHDFKAGPRLASAAD
>A0A7U3ZJ50|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MSNRRDFIKTLGLSSAGLMMGLSASSKPTVIQLNGTGPSALALEINPFIVIEPNGKIILI
NPRPDMGQGSTQAVPSLLAEELEVRLDQVTIWQSDGKGKYGDQTSGGSSSVRALWKPIRQ
AGAAAREMLVKAAAKRWGVPESECYAKEAKVFHRPSGKSLTYGEVADDASKFEVPKNPVL
KEAKDFKIVGKYAPRLDVPARVTGKAVFGIDVDVPGMVYAVMIHNPHLFGKVISIDDAEA
LKIKGVQKVLKCERPMPHRTAEAVAIIADNYWAALSAKKAVKVQWENGTMPQTLTTEAYF
KKCADAATKEGLKGEESGDFAAAFAGAAKKVEALYETPFLAHAPMEPENAIAHVKEDGTA
EVWAPIQGPDWALRDLAGYLKIKPEQIKINVALLGGAFGRKAYHDFLLEACFLSKEVKKP
VKLVWTREDDITQGPYRPGMMARMQGGVDEKGNIIAYHHHPIGESIQFQVFKAPNDKPDD
WICGELSKHEQKYEIPAFKVSFTHVSTEIPIVWWRSVYASNFGFSQEGFLDELIHTAGKD
PLKARLEMMPDARFKKVLETLAEKAKWGEKLPAGHGKGIAVFKSFGSISACCVTVSKQGA
GVKVEKVVSVIDCGHYVNPDNVKAQTEGNIVMGITAAVKKGITFTGGQSEQTNFHQYQVM
RFNEMPAVEIHIVESGAEPGGVGEPGLPPVAPALANAVFAATGKRIRRLPFDLNTLG
>A0A1E3H5R8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MPAFILNGRSVDVDAEPDTPLLWIIREHLKLTGTKFGCGMAQCGACTVHVDGEAVRSCVT
AVADVDGRAVTTIEGLSPDGTHPLQRAWIEEQVPQCGYCQSGQIMQAAALLATTPSPSRQ
EIVDAMDGNICRCGTYAGIIAAIERASREA
>A0A7W7KQ94|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas nitritireducens|TrEMBL
MLVPRLDNQPAQAGSILNVSRRSFLRGAGGLALGIYFAPLLGKLGDAQAASDFEANAFVR
IAPDGTVTVIAKHVEMGQGSYTGLATLVAEELDADWSHVQVEGAPADAKRYANLAFGNLQ
GTGGSNAMANSYEQMRKAGASARAMLVGAAAEQWKVPVEQIEVHDGVVSHPASGRKAGFG
ELAEAAAKQPVPTDVKLKDPKDFKLIGQVQLPRKDSPSKTDGTAQFTQDVHLPDMLVAVV
AHPPRFGGVPAKVDASKAKAVPGVVDVVQFPGSERRFAGVAVLAKNTWAARQGRDALQVE
WDESKAFKMGSKEIFAQYRDMASKPGLVARNDGDIGKALEKPAHLIEAEYQFPYLAHAAM
EPLNCVVFLKEDGCQIWNGEQWQTGDQMSVAQLLGMPPEQVNITQLYAGGSFGRRANPHS
DYVLEAVAIAKAAREQGVKVPIKMVWTREDDTRAGYYRPAFLHRARLAVDAQGNLVGWEQ
RLVGQSFIVGTPFEKFMVKDGVDKIAVEGAADLPYAVPNLRVEQALAENVTVPTQWWRSV
GHTHTAFSTETLIDEAAIAAKQDPYEFRRKLLAKHPRHRGALELVAQRANWLAPLEKGKD
GEQRGRGIAVHESFGSFVAQVVEVTYKADKSFKVDRVVCAVDCGLAINPDVIKAQMEGGI
GFALSAALHSAITLTDGKVDQSNFHDFQVLRINEMPVVEVHIVPSAEPPTGVGEPGVPPL
APALANALFAATGKRIRTLPIGNQLQA
>A0A7W7U0C4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces nymphaeiformis|TrEMBL
MPQHTFILNGKAVTADVEGDVRLLWVLRDVLGVTGPKYGCGVGVCRACTSHLNGKAFTPC
AVRVDDVAPTDEITTIEGLPDTVGAELHPMQEAWLDLDVAQCGFCQPGQIMAAVATVRKA
REAGREVTEADLDTIRNICRCGTYHRIRQAVLEGARRME
>A0A0P1GUD2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter sp. CECT 5382|TrEMBL
MASLKKIARRSFLVGSAAILGGVAFGTYKYHQPAPNPLEPGAGKAVLNPFVFLDQSGVTL
IAPRAEMGQGVRTSWAALIAEELDVDPNAVNVIHGPAAKAYYNSAMMAEALPGRGYNASD
FQHSLGQVVGNFSKFLDLQVTGGSSSMKDGFERMRRAGASARETLKEAAAQKLGVSRALL
ETKDGHVLAPGGVTLSYAELAVEAAGIAPQEVELRPAAQWKYIGKTVPRIDMVAKVTGTA
GFGVDTRIPGMKFAAIKQNPHFGAGMRSFDASAAEAMAGVEQILDLGDAVAVVGSNTWLA
QQAVNAITVDWEPASYPQTTEGLFAEIAASFDGSANSTLRDDGDVDDLPEGAEVIEAEYQ
LPYLAHATMEPMNATALYTGDALEIWAPNQGPTVVQKSAAELAGLETEAVTVHTTYLGGG
FGRRIEVDYADRAVQIARQMKGTPVQLTWSREEDMRHDFYRPGAIGRYRAAIKDGKAVMV
HGKIAAQSTTQEGAGRMLGLPMSGPDKGHVDAAFNQPLAIPNFRVEGYITKPMIPVGFWR
SVAASFNGFFSDSIIDEMAHKAGRDPLEFRLELARAEWEPGAKVLETVRDMSGWSGKTPE
GIGRGVAFVYSFGTPVAQVIEVADQDGQIAIKNAWIAADLGTAVDPRNVEAQLFSGLAYG
LSAACFGEITFDGGAVQQENFPDYDAIRMPSMPRVEVAVLQEQKHMGGAGEPGTPPAAPA
LANAIFDLTGTRARRLPLMHDFDLLS
>A0A375H389|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus neocaledonicus|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLEMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGADRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A7W9U289|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bannensis|TrEMBL
MSQGLLDAGRSAERAAASSGVSRRSFLKMSAAAGGGLLLGFSFDAGAQGDSAARKSVVGG
DGNEAPQDGVFEPNAFVQIDRTGKVTLIIPKVEMGQGVYTSIPMLIAEELEVPLDSVTLD
HAPPDAKLFTDPLLGGQLTGGSTSIRYAWEPMRRAGATARVALIAAAAQQWSVDAGECHA
KNGEVLHDASGRRASYGQLVDAAAKLPAPQNVTLKNPKDFTLIGKPTKRLDSPEKVDGSA
LFGLDVRVPNMVYAAIVNCPVFGGTLARVDDTHAKQIPGVTQIVKIDNGVAVIGAHTWAA
KRGAAALVIEWNEGATANLSMRQIVGDLANAAQQQPGAVARKDGDVQQAFGGAKTRVDAV
YQQPFLAHATMEPINCTVHVRADACEIWVGTQVPTRAIDAGVAVTGLKPEQIVLHNHLLG
GGFGRRLEVDAITQALKVGKQVNAPVKVFWTREEDIQHDMYRPFYYDRISAGLDANGKPV
AWQHRIVGSSIMARFAPPAFKNGIDPDAVEVAADLPYDLPNQLIEYVRQEPHTVPTAFWR
GVGPTRGTFVVESFIDECAAAAKTDPVQYRRNLLGKSPRALGVLDVATRAANWGPPMPKG
QGRGVSVMHAFGSFFAMVADVSVTNGEVRVNRVVAAVDCGMVVNPTTIEAQVQGGIVFGI
SAALYSEITIERGRVQQRNFTDYRILRIDEAPVIEVHIVPSGEAPGGIGEPGTAALAPAV
TNAIYAATGQRLRHLPVGRQLMNTQSA
>A0A5E6WZ92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALGNLSRRGFLKGVGATGALVLAASWGWQDALAEEKPKQFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELEADWAQVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHKPSGRELGYG
ELAAAASALPVPARDSLRLKQPSEFRYIGKEGSKAIDGADIVNGRAVFGADVHFDGMLYA
TIARPAVYGGKVKSVDDSAALKVPGVLKVLQIESRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQSPMEPMVAIARYKDGVCEAWAPSQAPQVTRERIAERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPSVRLENPEASVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGEDPLKYQIKLLGADRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPNGWGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E7SM78|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNVRIDPSLQASALDLHEPINVSRRRFLTGTAVGALVLGFGLPLGATRVQAAVAAATAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPSTFLVEAAPPGEAYV
VLENGMRITGGSMSVRMSYPVMRRLGALARAMLLQAGAQQLGVPVSELSTEPGKVVHAKS
GRSLAYGELAERAMDLPVPDPASVKLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKV
DNMLHAAVQHAPRLGMTVGNLRNEEQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTAESKVRPMPADFSSDAWFKRLAEDKSPAKDDENEGDVAAILKETKTRIDATY
HNQYLNHGQLEPPSALARFNPDGSLEVWLPNQAPDMFRADIAKRTGLDPSRITLHSPLLG
GFFGRHFLYDSASPYPQAIALAQAVGRPVKLIWSREEEFLRDVLRPVAAVNFRAALDNDG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKTYAIPNKRIAQIYVKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFDLRLHLLRDNKRLTTLLQAVAELSGGWKRGPF
TAEDGSKRARGVAMASPFGTETAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEEAVWIDGKPRARNYDLYPILPPARMARVHVRVVESGEKMGGIGEPPL
PAVAPAVANAVARLTGQRVRSLPMSRHTFS
>A0A5E7V9P4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNTLILNGQPYKMDVPDEMPLLWAIRDVAGGHPGTKFGCGMGLCGACTIHIDGQPARACI
TPLSSANGQNVTTIDELHNDPVGKIVQQAWLDTAVAQCGYCQGGQIMSATALLKTNPNPS
DAQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7ELK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSLNPLSRRGFLKGTAVLGGGLVVAFVIPGAHRFAAAAENQGNVFAPNAFLRIGNDNTV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIKVEHSPASAADYGMAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIEAAAKRFNVPPSQIRTESGVVIAGDQRATYGELADDAGKL
PVPDPASIKLKEAKDWTIIGKPTKRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPVFGG
KVKSFEGAEALAIPGVHKVLQVPTGVAVIADHYWAAKLGRDALHVEWDLGPNAGLDSQKL
LESFRKLAATPGLPASKAGDTSAALAKAVKKLDVEYSVPYLAHAPMEPLNCTVNITQDKC
EIWTGTQFQTLDQLIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVYVAKAAG
GPVKTVWAREDDIRGGYYRSAFLHQAQVGLGADGLPVAWKHVMVGQSIMAGTSLEATMVK
DGIDKTSVEGVADSPYLEGMANHQVDLHSPQTGISVLWLRSVGHSHTAFVMESLIDELAS
AAGKDPVEYRRTLLKEHPRHLGVLNLAVEKANWKAPLADGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCIAFGLGFTLHSHLTFKDGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E7N487|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDALADEKEKKFGADGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELDADWAHVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHKPSGRELGYG
ELAAAASALAVPARDSLRLKKPSEFRYIGKEGTKAIDGDDIVNGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVLKVIQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAAALKPGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQAPMEPMVAIARYKDGVCEAWAPSQAPQVTRERVAERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGEDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGSLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPQGDVPLGGVGEPGVPPIAPALCNAIFAATGQRIRNLPVRYQLQGWQKAGA
>A0A017HIW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubellimicrobium mesophilum DSM 19309|TrEMBL
MTLSLSRRGFLGAAAGGLVVAFSLAGPLRAQEQAEGPELPGDLADTPNLDAWIRISPEGD
ITVFTGKAELGQGIKTALRMVAAEELSVVPGEIELITADTGLTPDEGFTAGSQSMSNSGM
AIRHAAANVRVLLLEEAARQLGVEAASLTVGTRLCRAVAGRWATATSRPRSTSRSRCGWR
CPIASRATTASSAPTCSASTFRARSRAARPTFRTCGPRAWSMPASSDRRAPARPSPPSMR
RASRPSPGPGRRPGRELPGRRGRA
>A0A6S7DTP6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter anxifer|TrEMBL
MTHTAQLSRRGFLQGALGALTLAVTSKGLVTTAWAAESGAQKYGADSMPGGTVDDPLVFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWDRVKIVQAQADEARYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPVAEVKAVQHEVLHQPTGRRLAYGELAAD
AAKQPVPAGDALKLKDRAEFRYIGKDQVRLVDLEAIGKGQASYGMDMHLPGMVYAVVARP
PVVGGKLRRFDSAKALAVPGVLKVVEIPPMQGAPAFQPLGGVAVVARNTWAARQGRDALE
IEWDDGPNGSYDSNTYRQTLESAARKPGKAMRNQGDAAQAWAKAPEAERVTAEYYVPHLA
HASMEPPAATVLIKDGRAEVWTSVQNPIAARDAVSARLKLEPAKVTVNVLLLGGGFGRKS
KPDFVDEAAIVARAMPEGTPVKLVWTREDDIHHDYLHTVSVERLEAVLDKNGQVQSWLHR
SAAPTIASLFSEGAKGQQLFESAMSAINMPYRIPNVRVETAEVEAHARIGWFRSVANIPH
AYAAQCFIAELAHRAGKDPKDFALDLIGPARRIDPGTMADTWNYSESPERYPYDTGRLRG
VIEAACKGAEWGRTLPQGHGLGLAFCYSFMSYTATVVEVAVDAKGQVRVVAVDMAMDCGP
QINPERIRAQMEGGAIMGLGLAMVSEISFEKGRVKQSNFHDYEVLRHNASPRVIRTHLVN
DDHALPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVA
>A0A7W8D7I5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chiayiivirga flava|TrEMBL
MTTLHVNGKTLTLDVPDDTPLLWALRDAAHLTGTKYGCGIAACGACTVHVDGQAVRSCVL
PVSAVAGKQITTIEAVDGDAVGKAVQEAWRKLDVVQCGYCQSGQIMSAVGLLKVVKQPTD
EDIDRAMAGNVCRCATYVRIRAAIHDAAASLA
>A0A7Y7H7B7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mucilaginibacter sp. SG538B|TrEMBL
MNRRNFIQSGALLSGGLLISFTIPKANKLAALADTADLNVFAPNAFLNIGTDNSISVYLS
HVEMGQGVWTTLPMLIADELDVDLKKINIKHGGADKAFNHVIYGAQITGGSSTTWSEFDR
YRNAGATARTLLLQTAATRSGTAVESCKTEDGFVIAGSKRYTYGELANDAAKLPVPAKVP
LRSSTDWRYIGKGSKRMDARVKTDGSAKFGMDIQFPGLLTAVVAHAPVFGGKVKSFDAGK
AKTIPGVREVVQIPTGVAVIADHFWAAQQGRKALQITWDHGAGVQLNTGAQTAAYRKLAA
SDGLLVQEKGDVKAAFPKAVNTISAEYVFPYLAHAPMEPLNCTVKIENNSCEIWTGTQLP
GGEQAAAAKILGFKPEQVKVNIPFLGGGFGRRATPACDFVSEAVHIAKASGRPIKMVWTR
EDDMKSGFYRPFYVHNVKIGVDKDGLPIAWNHNIAGQSIMADAAVLFGPPPAIDDTTVEG
VKGSPYLDEIPNHFVGLHTTKEVVPVLWYRSVGGTHTAFVMETLIDQLAHNVSIDPVEYR
RGLFKNHSRHLAALNLVAEKGNWNRTLLPGRFKGMAVHEAFGSVVAIIAEVSVDKGVTKV
HQVDCAIECGLAVNPDGVKAQMESGIIFSISMAMYGELTFVNGELQQNNFYDYRITRMHE
APRINVYIVDSKEKMGGAGECAVPPTAPAVANAIFAATGKRIYNLPIVNNRLEKQA
>A0A840E7U4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lewinella aquimaris|TrEMBL
MSVQHTSRRSFLKVSAATGGGLMLGLSWLTSCESDKANKADPELQMPAEWVTVNAFLKIG
DNGVVTIMSPNPEIGQNVKTSMPMIVAEELDVDWKNVIVEQAGLDTENYTRQLAGGSQSI
RHGWEPLRKTGAMARYLLVAAAAQQLEVDASELRTENGVIYHDGSDRSLGYGEVASLAAT
LTPPEEVTLKDPADFKIIGHGKKNVDARKIVKGEPLYGLDVQREGMMYAAIVHPPAFGLK
LKSVDDTEARSMPGIHDVVTIDARPEGVEQQWSDVNAFPQLVAVVGNNTWRVLQAKKALK
IEWESDSAPESTAGHRSALEDLLNDGKAEEARRDGDPEAAFASAATVVERSYSAPFLPHN
TMEPMNFFAHVTEDKAELVGPIQTPEFLRKTVSALLNMPEEKIDIMMTRMGGGFGRRLYG
NFGVEAVLISKAAGGIPVKLVYSREDDMTQGTYRPEYLVRYRAGLDEDGKLIAFHVRGTG
ANESPVFANRFPAGTVDNYLAENLSIETNVSTGAWRAPRSNFIAGAEQAFLDEVAEAAGK
DPIEFRLELFERAKTDPVGEDNDYDAERYAGVLELVRDKSGWNTNDDKRGVAAYYCHNSY
VAQVLELEMKGSEPRVTEVHCAVDCGIVVNPEGALNQIQGGIIDGIGHALYGAVTFTDGK
PDQQNFDTYRLIRHAEAPQSIHTHFVDNGIAPTGLGEPSLPPVIGALANAIYRASGERVY
EQPFAKPRELKG
>A0A0U5B619|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter senegalensis|TrEMBL
MFVTWTRADTPVPVGWWRGVGPAHNVYVVESFIDELAAATHTDPLEYRLRLLGKNPRSVA
VLKRAAEESQWSKPLPTGTGRGLALHNAFGSHCAVVTEAVVTDKKSIAIKKVTAVVDCGI
AVNTDALIAQMEGGLLFGFSAALYGEITIKNGRIEQSNFHNYPLMRINDAPPIDVHIIKS
TDSPGGIGEVGTTAAFPSLGNALFNATGKRCRRYPFSPHFFNGEFGSI
>G2PJ78|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda ruestringensis (strain DSM 13258 / CIP 107369 / LMG 19739 / B1)|TrEMBL
MATYTINLNGEDQSFTCDENMPLLWVLREVLQKTGTKYGCGIGQCGACTIHLDGNAVRSC
MMPISAVGEAKITTIEGIGDPELHPVQQAWKELQVPQCGYCQSGQIMSAVHLLQQNPDPS
DDEITEVMSGNICRCGTYDRIKKAVRLATKLLENNQLP
>F7PU88|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haloplasma contractile SSD-17B|TrEMBL
MSNISVNQKNITKDISKQLMELCPFNAFEYDNGVLSINAACKMCKLCVKKGPEGICSVLE
SKVTTINKDEWNGIAVYIEHKNGIAHPVSFELIGKAKELASVINQPVIAILIGKDVTDLA
NEVLTYGVDTVYVCEEKDLEQFNIELFTEVMEKFINEHKPNTILFGGTYLGRSFAPRVAA
RFKTGLTADCTVLEMKENTDLLQIRPAFGGNIMASIITENHRPQLATVRYKIFKKPEPVE
PHGEIKYMNYNLNKKTTITILEQITKEQTVDLSEAELIVAVGRAFKKQEDLKMAEELAEL
LGAELACTRPIIENGWMDARKQIGLSGRTVSPKLIINLGISGSVQYVAGMKGSDCIISID
QDEDCSLFDVSHYAIVGDLYKILPTLINKVKTNKSLI
>A0A369QD52|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Adhaeribacter pallidiroseus|TrEMBL
MAQYKLQVNGRSYQADVEPDTPLLWVLRDHLGLVGTKYGCGIAQCGACTVHVNGEATRSC
VYPVSALGKSKVVTIEGLSPKGDHPVQQAWNEVDVSQCGYCQAGQIMTAAALLKKNPKPT
SAEIDAGMTGNICRCGTYHRIKEAVQLAATKTK
>A0A840X377|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rubricella aquisinus|TrEMBL
MGRARTIARRSFLIGSAAIVGGVAFGVFVAKRPIPNPLLETLGEGEAAITPYVKIDASGI
TLITPRADMGQGSYSVQAYLIAEELDIDPTTATLTPGQPGPAYFNRAVLGEVVPFAAHNR
SAMAEGLRNAMAVPAKFLAFQMTGGSSTVPDSYTRLRMAGATARETLKDAAARQTGHARA
TLRTEDGHVILPDGTRIAYTALARHAAEIAPVTDVTLRDPSEWRYLGREGLMRTDMRAKV
TGEERFGIDITFPGMKFATVRANPGLGGEVIRYDASAAETMRGVERIIPISHGIAVVADN
TWRAFRAADALEITWGAPDYPATSEAMFDTLEQTLSARRGREPRLRNDGDAAQVLENAPR
VIEARYRVPYLAHAPLEPMNAVVHASPARLDIWTGTQIPLFIRDRAARIAGIDKGDVHVH
VYPMGGSFGHRLEMTHVEQAVEIARALPDTPIKMTWSREEDMTHDYPRPAAVAHARGTVT
EGRVECLDLSVAQSGMLSSWFGRLMGLPVPGYDPTLTAGAWDQPFAIPHYRVTGYRAQEM
VPISSWRAVGATSNGFFHDCFLDELIHAAGADPLAERIRLCSDPTSRRVLETVGELAGWT
GPDLGPQRGRGVGFTQSFGVPCAHVVEVTQTDRGIRIDKVFTAIDSGRVLDPTNYRAQGM
GGVIWGLGHAMNCALTYENHAPQQTNFDSYAGMRMYQVPQIEIRILEDGQRIRGVGEPPV
PPAAPALANAIFAATGQRIRTLPLRNEIAFL
>A0A7Y9UGY0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. IAR9|TrEMBL
MNFIDNPGKLHSFEKRGFEKNIKVEKVSRRSILKGLGITGGFVLAAPVMSRQALAYETGA
GKMPHGVVVDPRVFVSVGPDGIVTIVGHRSEMGTGVRTSLPLIVAEEMEADWSRVKVQQA
HGDEVKFGNQDTDGSRSTRHYLIPMRQIGASARTMLEQAAAKRWGVPATEVKAVNHEVVH
SASGRKLGFGELAADAAKESVPSIEGLKLKDPKNFRYLGKGQVGIVDLHDITTGKAHYGA
DVRLPGMKYAVIARPPVTGGKLVSFDPDAALKIPGVEKVLKVQGWPWPSKFQPLGGVAVI
ARNTGAAIKGRDALKLVWDDGPNGKYDSVAYRKELEEASRKPGLVLRKEGDADAALKGAD
KVIVGEYYVPHLAHVSMETPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLGIPEGNVTV
NVTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDIHNGFLHTVSVERIEAGLD
KSGKVVAWRHRSVAPSIASTFAAGTVHQAPFEIGMGLVDMPFEIANISCENPEAAAFTRI
GWFRSVSNIPRAFAVQSMVGEIAQATGRDQKETLLALIGSPRIVKPEVKDLWNYGEPQES
YPIDTARLRKVVELVAEKGEWGRKVPKGHGLGIAVHRSFVSYIATIVEVAVDDKGKLTVP
RVDTAIDCGTYVNPERIASQIEGAAIMGLSLAKYGEITFKDGKVQQKNFDDFQVVRMDES
PVVTNVYIVPPGPDTPPSGVGEPGVPPFAPALINAIFAATGKRIRSLPIGKQLEA
>A0A7W6FWU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium fluoreni|TrEMBL
MASRRGVLVGGLAAGALVVGYALRPRRYALPLPPGRDEVAFDAWIKLADDGVVTVAVPQV
EMGQGVTTLIPQIIAYEMGADWRRVAVEPAPPSPLYANVPLASRWAELTMPAMPDALLGD
DAALVRRWAQDHTFTVTADGTALAAYEGPARAAAAMARALLCMAAAERWDVDWRECDAKD
GFVVHKGKRLPFGSLARAAAALDPPRSPPLRDAPPAERPGVPMAYPRLDLPAKVDGSLVF
AGDVRLPGMVYASIRHGPIGESALADYDKTAANGVRGLITLVRNRGWIAAVASTWWAADQ
ALTRIDAGFTSTDRADSATIDQAMETAMQTGTATRLAERGDPDAFLTGRLPLQLRYEVQP
ALHASIETASATARFKDGHLELWIGTQAPQAAREIAARALGIDVAAVTLYPMPLGGSFDR
RLENDHAGEVALIARACQRPVQLTWSRKQEHIVGHPRPPVAAVLGANVDATGRLGGLRAR
IVAPATAREFGRRLLHADSPRAAIDAVAGVADPMMIEGAMPPYAIDHLAIDHVPVRLPLP
TGRMRGNAHGYTAFFVESFLDELAHRAGREPLAYRMAMLGHDPRLADCLQRVAVLSGWGG
GADNSGQGIACHLIGSAESGGRIALVASARRDADGVTVDRLSAVADIGRIVNLDIARQQI
EGGLIFGLGLALGCSTGYEGGLPVTGRLASLNLPVLADCPAIDVNFITSSAAPADPGALG
VAAVAPAVANALFSATGLRLRQLPLLSEDV
>Q124U1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polaromonas sp. (strain JS666 / ATCC BAA-500)|TrEMBL
MIRRADTPLTRADFHVAEGVLLVTREPPTAPPTVNGQPALVSANPLEGVEILIAVWDDGS
VTALNGHVDLGTGIRTALAQIVAEELDVTLDSVNMVLGDTARAPNQGATIASASIQIHAI
PLRAAAAQARAWLVARAAEHLQVDRATLGVRDGVVFGNGGDARSLAYGPLLALQHVELSL
ALDTPLKAPEDHRIVGTSTARLDIPAKATGALTFVHDMRVPGMLHGRVVRPPYAGADHGD
FIGNTLESVDESSIAHIPGIRAVVVIRDFVGIVAEREEHAEQALRELAVQWKHWPGLTNL
NDLEHAIRSNPATQRKLVDEGDVDAAMAGATQVMPRNYVWPYQMHGSIGPSCAVADWQQD
RMTVWAGSQNPHVLRADLSRLTGLADVDIDVIRMEAAGCYGRNCADDVAADAALLSRAVG
SPVRVQLTREQEHAWEPKGAAQLMQVNGGLNEDGSVAAYDFQTSYPSNGAPTLALLLTRT
IEPVAQAYEMGDRTARPPYDYDNLRVTVNDMPPMLRASWLRGVSALPNSFAHESYIDELA
TAAGVDPVEFRLRYLTEPRAAELVRATAERAGWRVHTQPQQQALRQGEPADIVHGQGVAY
ARYMHSKWPGFGAAWAAWVADVEVNRKTGEVHVRRVVVGHDAGTLINPAGVQHQIHGNVV
QTTSRALTEQVTLSPKTNTVASLEWGAYPILSFRDVPVIEVVTMARPGEPPLGAGESASV
PGTAAIANAIFDATGVRFRQPPFTPEVVRAALNPSQESEPVAPPALTGRPLARPPEGAAW
PKGRGWWSRTGALLAGIFGVAAALVGWRPAIAPVLPSGASIYTAATLERGRQLAAAGDCV
VCHTAPGGIPNAGGRAMDTPFGKIVTTNLTPDVDTGIGLWSFSAFQRAMREGISRDGHHL
YPAFPYTAFAKTSDEDLTALYAYLMAQPAVRSEPPATRLTFPYSVRPLMAGWNALFHDPA
PYQVSPTQTVEWNRGAYLVNGLGHCGACHTPRNAFGAERGGKAFLGGAMVDGWEAPALTA
LSRAPVPWTAAELYRYLRQGYTPQHGIAAGPMGPVVKELSVLPDEDIRAMATYLASFTEP
ASEPASAERARQVVLSAQKSAGGLLGPGQRLFNGACASCHHDGEGPRLLGVNTPLALNSK
LHSERPDNLIRVILSGIRSPAAADIGFMPAFRHSLDDTQIEALAAYMRSRYAPAEPAWQD
LPGTVSRLRGAVDEH
>F4L2R0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MTTVKTSNGRRSFLKSAALAGGGMMLGFEWLTSCQSSTATIAPASSAKAWYKFNGFLSIA
DNGTITILSPNPEGGQNVKTSMPMIVAEELDVDWKNVVVEQAPLNTALYTRQFIGGSQGI
RQSWQTLRMAGASARQMLREAAAQSWGVPVAEISTASGALSHKASGKSATYGEMASAAAQ
IPVPKEVALKAVKDFKIIGSSRKNVDATKIITGQPLFGIDSRKEGMLIAMVIHPPAFGLK
LKSFDDSAARNMPGIKAIFPIKAVNPEYEKQFFDTLTFPDVVAIVGNSTWEVMQAKKAIK
IECEPIPETTETVNRLGSKQTVRTPAGLENTPTHQAKIAEIAAQPGRVRRKDGDPETAFK
TAAKIIERTYTAPHLAHNCMEPMNFFAHVTTEKAELVGPLQKPEFTEQALAARLGMPLEK
IDFQMTRLGGGYGRRSYAHWALEAALISQKMQAPIKLMYTREDDMTSGIYRPAYQATYRA
ALDANNQLIAFHVKTGGIPESPLAANAFPAGAIDNYLAEDWTIDSNITVGSFRAPRSNFM
ASAEQSFLDELAEAMGKDPIAFRLDLLNRAKTNPVGKNNDYDPTRYAGVLELVREKSGWG
QSQTNVHRGVSAYFSHNSYAAQVLDLVLKDGKPIVKRVCCALDCGIVVNPDAAINMTEGA
IVDGIGTALYGSITFNEGVPDKSNFDKYRMIRMGEAPQTIDVHFVKNEIAPTGMGEPPYP
PVFGALANALYKSRGIRLYQQPYLGEKREFG
>A0A378YLZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea pnomenusa|TrEMBL
MEFQLNGRPFVFDGDDDTPLLWVIRDAAGLTGTKYGCGIGACGACTVHVDGEATRTCVLP
VSAVAGKRITTVEALSPTRSHPIQQAWIAKDVPQCGYCQSGMVMAAAALLRKHPRPTDAQ
IDEAMTNLCRCATYHRIREAIHDAAKR
>A0A2C6DJY5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Budvicia aquatica|TrEMBL
MASSREIKVNGQWIRLDNTPPTTPLLYALRNDLMLNGPKYGCGLGECGACTVLINGVATR
SCITPVSAAYQKEITTLEGLGTEQNMHPVQQAFVEEQAAQCGYCTNGMIMTLVALFERNP
KASEDEIKQELAYNLCRCGTHMEILSAAEKAKALLAERASA
>A0A0U5EQH2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter senegalensis|TrEMBL
MIKFKLNGRDVSVDVPDDTPLLWALRDELDQTGTKFGCGVGQCGACTVHVGGRATRSCIT
PVSSIEGAEVTTIEGLHPEGKHPVQEAWRDIQVPQCGYCQSGQIMQAASLLKDYPDPTDE
QIDGVMGGSLCRCMTYIRIRKAIKKAAAAMREETASNG
>A0A5S9NUS8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania aliphaticivorans|TrEMBL
MAELNFTVNGQAQALTVDAGTPLLWVLREQLAMTGTKFGCGMGLCGACTVHVDGNPVRSC
SYPVEFIDGKSVTTIEGLAESDDALHPVQQAWLEMNVPQCGYCQSGQIMSAVALLASNQA
PSDEQIDAAMSGNICRCGTYPRIRKAIHRASELTVQYYQPNKTSEVAS
>A0A2N7WAG7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia rhynchosiae|TrEMBL
MTTESDFTDAVRPSRRTFLKAAGAVAAVGVNIGLTIGFEWAGMGRRALADTMPDTTFAPN
AFLRVAPDNSVTIIAKHVEMGQGAYTGIATIVAEELDANWQDVRVESAPADAKRYANLAF
GTMQGTGGSSAMANSWMQLREAGAKARVMLVSAAAAQWQVPVTDLVTRDGSVHHAATSRS
ATYGSLASAAARLPVPEKVALKSPKDFRLIGHQLPRVDVPAKTDGTAQFTLDVTLPGMLV
ALLQRPPLFGATVKSFDASAAKAVPGVVSVVQVPGGVAVVAKGFWAAKQGRDALKIEWDD
SKAEKRSSDAIMAEYRQLAEQPGASARKDGNAEQALAGAAKKISATYAFPYLAHAPMEPL
DAVVKLTADSCEIWAGDQFQTVDQANAARTAGLDPQQVKIHTLYAGGSFGRRANTRSDYI
VEAVSIARALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAGLTADGKLVGWRHRIVGQ
SILAGTPFASVMVKNGIDATSVEGAANVAYAIPNISVELTTTQTGVPVLWWRVVGSSHTA
FAVEAFIDEAAHAAGKDPFVFRRDLLTHEPRMRAVLELAAQKAGWDPVNPLPKGRGRGIA
VAEAFKTFVAQVAEVSVDKDGNVKVERVVCAVDCGTPINPDIIAAQMEGGIGFGLGAALH
SAITLKDGKVEQNNFDTYQVLRIAEMPKVEVHIVQSGEAPTGVGEPGVAPVGPAVANAIF
AATGKWLHSLPFPAGAQKSA
>A0A0S4UUM7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MVTLTINGRPVEVDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAAVGAQITTSEHIADDKIGKAVLAAWIKHDVAQCGYCQSGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAAKALA
>A0A1E3EH71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MPNLNINGRNMSVEAANDTPLLWVIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
SVADAVGKKITTIEGLSAKGDHPLQKAWVAEQVPQCGYCQSGQIMQAAALLSKNTNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAASDMRTASATGPERRAT
>A0A2D5J136|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium|TrEMBL
MQLNINGTTHDVDVDDDTPLLWVIREELGLTGTKYGCGVAQCGACTVLVDGYPTRSCVTP
ADSVIGAEIKTIETVEETETGRRVVEAWVANQVPQCGYCQSGQVLAATALLTETPQPTDE
DIDDAMVNLCRCGTYNKIRAAVRSVSEA
>A0A427MBS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium pisi|TrEMBL
MINNLHSRRGFLKGTVLATGGLVLAVQLPRMGRATGPASSSEEAAFTPNAFVKIDENGIT
LIMPHTEVGQGIYTSSAMLMAEELELRLDQLKVEAAPPDLSKYMDPILYDQATGGSTSTR
SDWMRLRQAAATARIMLVGAAAAKWRVDPAQCRVHEGTIYHDASNQSSTYYDIAAEAAKL
PVPADVPLKDPSQFKVIGTRAKRLDTPGKVNGSVVYGMDIRVPGMKYATLAISPVTGGRF
TKMNEAAARAVKGVLDIVTADNAAVAVIGEHMWAAKQGLDALNIEWDAGENGAVTVDTIV
AKMDQVSQQPGVVIRDENKAVDVIANAPTKLSAIYRSPFLSHSPMEPLNCTLHIQDDRAE
VWVGTQVPVRTQKAVADITGLPPEKVTVNNQLMGGAFGRRLDVDTIELAAKLLKDTRYPV
KLVWTREQDMTHDYYRPYYYDRVAAGLDKDGRMIGRTHRVTGSSIFARWAPAAFKNGIDP
DAVDCASETPYDEEAVFADYVRDEPAGVNTSWWRGVGATHNLFVVESFVDEMATATKQDP
LEFRRKMLTKNPRALAVLNLAAEKAGWGQALPPGRGKGISLQVAFGSYLAHILEIEITDE
KEVRLVRSVIAVDCGVVINPDTVVAQMEGGVIFGLSSAMFNQVTFTDGAVDQTNFDTYRV
LRINEAPKIEVYQIKSGEAPGGVGEAGTAAAAGALGNAIFAATGKRIRSLPLAEALA
>A0A1Y5RAI5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius litorisediminis|TrEMBL
MGRLKTIARRTFLIGSAAIVGGVAFGTVMYKRPAKNPLLQDLGPGAAAITPYVLITQEGI
TLITPRADKGQGAYSVQAALIAEELDVELDQITVDPGTPSPAYYNTALANDMAPFRSTDD
SIIAEFTRAVLDAPVKFLGIQITGGSTTVPDSYEKLRMAGAVARETLKAAAAKVSNQPVD
QLTTARGAVHLPDGRMLTYIELAATAATLNPVTDITLRDPQDWRLIGKPMQRIDIAAKST
GTQAYGIDIRMPDMLHAAVTLNPRRGSVNSYDATTAETMRGVRKVVPVTGGIGVIADNTW
RAMQAAKAISVDWGAAPYPADMDAHWKSLTDSFTDDQLDSQYRNDGDIAGALGNAEPVSA
EYRAPYLAHAPLEPINATVLVTDARVDIWTGTQIPRFIQANISKITGIDADNIHVHVLMM
GGSFGHRLEDMVVRQATELAMTVKGTPVKLTYSREQDFAQDFTRQIAMAQLRGTLRNGQV
DTFDLGIAMPSVIGSQMGRQGFPAAGPDTQIVAGAWDQPFAIPNYRITGYRAPELAPISS
WRSVGASTNGFFHDCALDELIHAAGADPLAERIRLCNHAASRTVLETVGEMSNWGSKLDE
NQGRGVAFCLSFGVPCAEVIEVTATPAGVRIDKVFAVADVGRIIDPVNFEAQVSGGIVFG
LGHAMNCEITYADGAAQQSNYHQFEGLRLYQCPEIKVRGLENGRTIRGVGEPGVPPAAPA
LANAIFAATGQRIREMPFNKYIKFV
>L8MGR5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas furukawaii|TrEMBL
MGKFESRFRPEGGILNLSRRGFLKGTGGLALGVVFAPLLKGGEALAAAGDAFVPNAFVRL
GTDGSVTVLAKHVEMGQGTYTGLATLLAEELDADWNQVRVEGAPANAALYNNLAFGPIQG
TGGSNAMANSWEQMRKAGASARAMLVSAAAERWKVPASEIGVSQGVVSHAASGRKAGFGE
LAEAASRQAVPAEVKLKTPDQFVLIGRERLSRRDSQDKTDGTAVFTQDFKLPGMLVAVVA
YPKRFGAVPAKVDSSKAKAVAGVVEVVEFTDTPHGRAGVAVLATNTWAARQGRDALVVEW
DESRAFKLGSAEIFARYREAAGKAGAVAGKQGDISTAMAQPATLIEADFEFPYLAHAAME
PMNCLVKISAGQCDIWNGEQFQTVDQLSIAKYLGIPVEKVSLTQLYAGGSFGRRANPRSD
YLLEAVAITKAARAKGHDVPVKLVWTREDDTHAGFFRPLFLHRAKLALDAEGNLQGWHQR
LVGQSILKGSPFEGVMAKEGIDPTSVEGVANLSYAVPNLLVELHSPDDIGVPVQWWRSVG
HTHTAYSVETLIDQAATTAGKDPYEYRRALLGKHPRHLGVLQLAAEKAGWSQPLKAGAEG
EKRGRGIAVHESFGSYVAQVAEVTVKADGSYRVDRVVCAVDCGVAINPDVIRAQMEGGIG
FGLAAALHGAITLKDGVVEQSNFHDFQVLRINEMPVVEVHILPSAEAPTGVGEPGVPPLA
PALGNALHAAVGQRFYSLPLPRQLKLA
>L8MEE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas furukawaii|TrEMBL
MITLNLNGKDHELDVPADMPLLWALRDVANLTGTKYGCGMALCGACTVHVDGQPTRSCVT
PVSVVAGKKITTVEAVGQDPVGEAVQAAWRRLDVVQCGYCQSGQIMSATALLKGNPRPSD
ADIDAAMSGNICRCATYVRIRAAIHEAAGNLA
>A0A485EQB4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MRGVSALPNVFAHESYVDELAHLAGIDPIAFRRRYLDDQRALALIDALVARAGWQPRTSP
NPEARRDGLLKGRGFAYARYFHSKFPGFGAAWAAWIVDVEVNPENGAVRVAKVWVAHDCG
QMVNPDGVRHQVHGNVIQSTSRVLKEFATFDRRGVTSLEWGGYPILGFPELPEIDVLLLD
RPEQPPMGAGESASVPSAAAIANAIFDATGARLRQVPFTPERVLAALRSAQA
>A0A7W6J5U4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Gellertiella hungarica|TrEMBL
MRLTVNGKMHELDAEPDMPLLWALRDILDIKGPKFGCGAGLCGACTVIIDGEAVRSCQTA
LQDATGEIRTIDGLADGDRLHPVQQAWLDEQVAQCGYCQAGQIMNAVALLEKNPRPTDAE
IDEAMSGNLCRCGTYPRIRAAIHRAASQGEGV
>A0A0J5QH52|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Puniceibacterium sp. IMCC21224|TrEMBL
MQARFTVNGEERQVDVPEDMPLLWVLRDELALTGTKYGCGIAQCGACTVHLDGMAVRACQ
VEARELDGSTVLTIEGLGTPEAPHPVQQAWIETQVAQCGYCQSGQIMQAASLLAGNPDPS
DAEIDAVMSGNLCRCGSYPRIRTAIRAASAAVGR
>B9BHY6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD2|TrEMBL
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTL
ALSSVGSARITTSEHLADDAVGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAARALA
>A0A2N9LC20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderiales bacterium|TrEMBL
MVRNMTTLNINGEPIEVDADPSTPILWALRDTLGMTGTKFGCGVAACGACTVLINGQPAR
SCVSPIAGAVGQKITTIEGIATGRVGKALQAAWIAHDVAQCGYCQSGQIMSAIGLLESNK
KPSDADIDSAMAGNICRCGTYQRIRAAIHDAAKNLA
>A0A840LEV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paucibacter oligotrophus|TrEMBL
MKDHTALSTTRRGFMQRSAGSALVVGFSLPLAGGLAAKVQAATASAPQTNTFAPNAWLRI
TPDNRITVLCGAAEMGQGVLTAIPMLVAEELDADWKLVAVEQAPAHTAYNNPLFGMQATG
GSTTIRAHWTPLRQAGAAAREMLLAAAAEQLKIDVSHLRSERSHVIAPGGKKLSYGALVE
AASRQPVPDKPLLKSRADFKILGKPTARLDTPAKVNGKARFGIDAQIEGMLVAVMARAPF
AEAKLKSMDESAARAIKGVQKIISIPQGVAVLAEGYWAAKQGRDALAVQWELGEKAQLNT
AKISEMLNDAANTAGAIAVDKGNLKDAAANSAQRLSASYEVPYLAHACMEPLNCLAWVKN
DEVTIWAGTQSQGPAQGILGQIAQVTPAKVKVNTLLLGGGFGRRFAPDFTVDATLLSKLS
GRPVKLIYSREDDMAAAYYRPAALVKFEAALDEAGRASSLRADVASPSIMAGSGFMQLPE
SGVDAQAVEGLADHLYDIPNQRIAYGRAEPGPQVWFWRSVGHSQNAFFIESFIDELAAAA
KADPLQYRLQMLDKQPRARAVLEAAAAKAGWGQVLPAGVKRGIAFAESFGSFVAEVAEVS
VSSDGRPKVHRVVAAVDCGQTVNPQTIARQIEGAIVYGLSAALYGQITLKDGRVEQSNFH
DYPVLRMSEMPKVEVHILPSTAAPGGVGEPGTPPIAPALTNAIFAATGVRIRKLPIEPGL
LKKS
>A0A2K4XF83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoalteromonas carrageenovora IAM 12662|TrEMBL
MVTFTINGKVVESHASEDTPLLWVIRDEIGLKGTKFGCGIAMCGACTVHLDGQATRSCVL
PIGAIAGKNITTIEGLNNEHPLQKTWVEEQVPQCGYCQSGQIMQAATLLAANPNPSEEEI
VNHMNGNYCRCMAYKRIKTAIKRAADESQNVVNIFDPNAQDA
>A0A7W8UV94|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. HC6.4b|TrEMBL
MSQGLLDAQNGAQPADTDTRHARGISRRGFLKFGVTVGAAAGGGLLLGFSMPAASQDQKA
GKSVIGGDANEAPQNGVFAPNAFIQIDNAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LGTVTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARVMLINAAAQQWQV
DPASCHAQAGQVIHPASNRSASYGQLAQAASALPAPQNVPLKDPKDFKLIGTPAKRLDSP
EKVDGTAQFGLDVRLPEMVYAAIANCPVFGGTLASVDDTHAKTIPGVREVIKLDNAVAVI
GAHTWAAKRGLQALDIKWNEGAGAQVSMKRIVDDLAAASQHGGAVARKDGDVGRAFGDAK
SRVDAVYQQPFLAHATMEPVNATVHVRGDACEIWLGSQVPTRVVDAAVAVTGLPADKIIV
HNHLIGGGFGRRLETDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDTISAGLD
ANGKPIAWQHRIAGSSIMARFAPPAFKNGLDPDAVEVAADLPYDLPNQLVDYVRVEPHAV
PTAFWRGVGPTRGTFVVESFIDELAAHAKIDPVQYRRDLLGKSPRALNVLNLAAQAGNWG
SALPKGQGRGISVMHAFGSFFAIVVEVALEQGEVTVKRVNCAVDCGMFVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRINQTPPIDVHIVKSGEAPGGIGEPGTA
ALAPALTNAIYAATGTRLRQLPVGRQLHNA
>A0A7G6V4K4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MSRGLIEAGRATAGVSRRSFLKLGMSLGAAAGGGLLLGFSLPAAGDDARRSVIGGDAAEP
AQPGVFAPNAFVQIDRAGKVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
EKLFLDPLLGGQLTGGSTSVRYAWDPLRQAGATARTLLVSAAAKQWNVDPASCRAANGEV
QHPPSGRRASYGQLADAAAKLPVPKDVVLKKPADFKLIGTPAKRLDSPEKVDGTAQFGLD
VRLPGMLYAVIVNSPVFGGTVASVDDTAARKIPGVRQVVRVDNAVAVVGDHTWAAKRGAS
ALVVKWNEGAGAKVSTKDLFADLAQAAANGKGAVARKEGDVGKAFANAKTRVDAVYEQPL
LAHATMEPVNCTVHVRGDGCEIWVGTQVPTRARDTAQQLTGLSPDKIVVHNHLLGGGFGR
RLETDMIGQAVKVGKQVNAPVKVIWTREEDVQHDMYRPCYHDAISAGLDANGKPVAWQHR
IVGSSILARFAPPAVKDGVDPDAVEVAAELPYDLPNQLVDYVRQEPRHVPTAFWRGVGPT
RSTFVVESFIDELAAQTKTDPVQYRRALLDKTPRARNVLDVATKAAGWGTSLPKGQGRGV
SVMHAFGSFFSIVIDVAVDGGEVQVKRAVCAVDCGMYVNPNTIEAQVQGGIIFGITGALY
GEITIEDGRVVQTNFNDYRMMRINEVPPIEVHLVKSGEAPGGIGEPGTAATAAALSNAIF
AATGTRLRKLPVGNQLKTA
>A0A107L340|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MIDIVVNDTRHSLENVPDDMPLLWVLRDRLRLTGTKFGCGKGLCGACTVHLEGQAVRSCL
IPAVAANGRHVTTIEGLSPDGRHPLQLAWVAEDVPQCGYCQPGQLMQAAALLNGGQPVDD
AAIVSAMSGNICRCGTYARIHRAIRRAAAGDPALKAAAEPVKEA
>A0A084Y6M4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Accumulibacter sp. BA-91|TrEMBL
MVNTKIANASRRSFLQGAAGLTLGFCLPAIAPAGAGKAAAPAGQPFEANAFLRIGTDDSV
TVIAKHLEMGQGSYTGLATILAEELDADWQTVRLEGAPADASRYNNLFWGASQGTGGSTA
MANSWDQLRAAGAAGRAMLVNAAARRWQVPAGEITVRDGIVSHRRSKRQARFGELAADAA
REAVPASVVLKEAKDFRLIGKQAPRKDSVDKTNGQAQFTQDIQLPGMLVAVVAHPPRFGA
TVRGFDASAARRVRNVVDVVQIPSGVAVLASDTWSAKKGRDALQVDWDESRSFKLGSEEI
VARYREMAKSPGLVARRVGNTEQAFAGAARIVRATYDFPYLAHAAMEPMNCVIRLSERGC
EVWNGEQMATADQSRLAAIFGLTPEQVRINMLYAGGSFGRRANTHSDYVVEAAQIVKAIG
GKAPVKLVWMREDDMRAGYYRPLFHHALEAALDAGGQLTGWRHRLVGQSILLGSPFESMM
VKDGIDAVSVEGAANLPYAIPNLLVDLHTPKDIDVPVLWWRSVGSSHTAYSTEVFLDQVA
RAAGKDPVAWRLELLADHPRHRGVLRLAAEKSGWGTRLPAGVRGTRRGRGVAVHESFHSY
VAQVAEVTVAADGTVKVDRVVCAVDCGIAINPDNIRSQIEGAVGFALSAALHGEITLKEG
AVVEGNFDTYRPIRIGEMPRVEVHIVPSTAKPTGVGEPGVPPLAPAVANAIGAATGKYPD
RLPFRAEDLRA
>A0A379KDC3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas oleovorans|TrEMBL
MGKIETPDSATRGILNVSRRTLLKGAGGLALGIFFAPLMRGMDALAAGGPLEPNAFVRID
LDGTVTVLAKHLEMGQGSYTGLATLLAEELDADWDKVRVEGAPADVKRYNNLAFGPMQGT
GGSTAMANSWEQMRNAGATAKAMLVAAAAQRWSVPVSEISVDKGVVSHAGSGRSAGFGDL
VEAAASLPVPEQVQLKDPKDFKLIGKLELRRKDSTDKTDGSAIFTQDFKLPGMLVAMVAY
PPRFGGVPRSVDSSKAKAVRDVVEVVEFRDLPHGRSGVAVLAKNTWAARQGRDALVIEWD
ESQAFTLGSEEILAQYRDDAGKPGLPATSKGDTDAALAQAAKTVEADYEFPYLAHAAMEP
MNCLVKLSSDRCEIWNGEQFQTVDQTIISGYLGLTPEQVSLTQLYAGGSFGRRASSVSDY
LLEAVAITKAARDKGVDAPVKMVWTREDDTRGGYFRPLYLHRVRIGLDEAGKLQAWHNRI
VGQSIMTGTSMEPFMIKEGIDHTSVEGLSNLSYAVPNLQVELSTPSNIKVPVLWWRSVGH
THTGYVAETMIDEAAVAAGQDPYSFRHALLDSHPRHRGALELAAKQAGWDKPLAAGAEGE
KRGRGIAVHESFGSFVAQVAEVTVKADGSYRLDRVVCAVDCGIAINPDVIKAQMEGGIGF
ALAAAQHSAITLKEGRVEQSNFHDFQVLRMNEMPKVEVHIVPSAANPTGVGEPGVPPLAP
ALANALFAATGVRLRKLPFPAQIKA
>A0A088UB05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MRFMLNGQPFDFDGDPDTPLLWVVRDAAGLTGTKYGCGIGACGACTVHLDGEAARSCVLP
VAGVAGRAVTTIEGLSHDRSHPVQRAWIEKDVPQCGYCQSGMVMATAALLARHRKPTDAQ
IDAAVTNLCRCATYQRIREAIHVAAG
>A0A0N7LZI4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter multivorans|TrEMBL
MSITLKLNGKTHEVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLNGEPVRSCQ
TFIEDVEDAEVTTIEKMEEDKVGAAVQQAWMELDVVQCGYCQSGQIMNAVGLLKENAKPS
AEEIDEAMYGNACRCATYQRIRAGVQRAAEILEA
>A0A5E8AQ21|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Imperialibacter sp. EC-SDR9|TrEMBL
MAVFNLSVNGKKQQVDVDPATPMLWVLRDHLNLVGTKFGCGIAQCGACTIHLDGTAIRSC
QMPVSAVADKAITTIEGLSEEGDHPVQKAWLEHDVPQCGYCQAGQIMTASALLASNPNPS
DDEIEAAMNGNICRCGTYLRIKAAVKTAAANA
>A0A7X5UYS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas leidyi|TrEMBL
MTRFTVNNQPVAYKMDPRTPLLWALRDASNLTGTKYGCGTGDCGACTVDVDGTARLACQE
TIGALEGTFVTTIEGLSRDRSHPVQQALIAANVPQCGYCIPGVVMAAAVLLRGNRNPSEQ
DIKDAIPNICRCGIYPRLAEAIQNAARIARGDVAVPEAGHDAPGAPQAGP
>A0A841L7G2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polymorphobacter multimanifer|TrEMBL
MQMNINGKPVTLEADGDMPLLWALRDVIGLTGTKYGCGAGLCGACTVHLDGAPVRACQTP
VADVGTAKITTIEGLSATDLGRKLQAAWAALDVPQCGYCQGGQLMAAAALLRDTPKPSDD
DIDAAMAGNLCRCGTYTRIRAAIKQVAGVRA
>A0A841L8G6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polymorphobacter multimanifer|TrEMBL
MALTRRRLLIGTGVGAGLLVGWAAWPRRHAISWAAADDEVVLNAFLKVGLDGRVVVAVPQ
AEMGQGIWSGLAQIAADELGADWKTVSVEPAPLGAAYANRFALGEMTSGLPAPLRGPARW
TTDRVVEYFEMQMTGGSTSVRGFEAPLRAAGAVAREMLCRAAANRLSIEWTECGTDNGFV
THKANRIAFAELVKEAALLDPPRTATLRPIRTISGTSVPRIDLPSKVDGSAQFGADVRLP
GMHYAAIAQGPIGAKRTRIDKAKLPAGCQLVEQPGFVAVVARGWWQAKQGLDALVISYDR
GETPAGPWMEAALDAALDSQDGLETALVRDDADAVELLAGPVEGVIGAEFALPFLAHACM
ETMTATARIEDGRCELWTPTQSLTITTWAVARALGIADEAVTVYPTLLGGGFGRKIETDA
AMQAALIARAVGKPVQLIWSREEDFAHDFWRPAVAARLRGRVTGEGAGARITALAARVAV
PDVGASAIGRNLPRLGGSPKAGAQALEGMVRFPYDVPSVALEHVLVNVAVPLGFWRSVGN
SYTAFITESFIDELAASAGVDPGGFRLQHLGDKPRHAAVVRALTSATGALGRERNGDGST
SGTGMALWESFGSIVGVAAEVVVRGGEPPQVVRLIMAADCGRVINPDSVRAQLEGAAIFG
LSAALSGRASFADGEVLETNFDRQPLLGLAATPVIEIILIESEEAPGGVGEVGTPPVAPA
LANAIFAASGIRMRRLPLGGPLGERPLRTGASTGAIDAASGAATGAALETIDSGAEMAET
PQ
>I7EKH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter inhibens (strain DSM 17395)|TrEMBL
MSTTLRINGTPHEVDLPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGVGTPNTMVVVQKAWVANQVAQCGYCQSGQIMQAASLLAENPSPSD
AEIDEAMQGNLCRCGTYPRIRAAIHDAASMMKEA
>I7EVB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter inhibens (strain DSM 17395)|TrEMBL
MASLKKIARRSFLIGSAAIAGGVAFGTYKYHQPAPNPLAQEDGRAVLNPFVFVDQSGVTL
IAPRAEMGQGVKSAWASLIAEELDVDPAKVTVLHGPAAKAYYNSAMMSEALPGRGYDGSA
LQHSLGEIVGHMAKFLDLQVTGGSSSMRDGFERMRHAGASARETLKQAAADQLGISRDQL
TTEDGHVVAPDGTRLPYSALANAAASLAPIEADLRPASEWRLIGKDVPRIDMVAKSTGTA
EFGVDVRLPGMKFAAIRQNPHFGVGKTAFDASAAEGMAGVEKIIDLGDAVAVVASNTWLA
QQAVDAIDVTWEAAPYPETTEAIFEEIARSFDAAPNSTMRDDGDVDALPDGATVIEAEYR
LPYLAHATMEPMNATALYSGDGLQIWAPNQGPTVVQKKAAALAGLDVDAVEVNTTYLGGG
FGRRIETDYTDRAVQIAIQLQGTPVQLTWSREEDISHDVYRPGAIARYRAAIKDGKAVMV
HGKIAAQSTTVEGAGRMLGLPMSGPDKGHVDAAFNQPLAIPNFRVEGYLAKPMLPVGFWR
SVGASFNGFFSDCIIDEMAHAAGRDPLDFRLELARAEWEPAAKVLETVRDMSGWTGKTPD
GIGRGVAMAYSFGTPVAQVIEVADEDGQIRMTNAWIAADLGRVIDPKNTRAQMFGGMVYG
LSAACFGEITIDGGAVEQENFPDYDALRMHTMPTVQVELLENQPRMGGAGEPGTPPAAPA
LANALFDLTGKRARQLPLMHEFDLLI
>A0A7W8V1U6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia atlantica|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHVDGVAVRSCVF
PTAAVGERKIVTIEAVGATPTGQKVQQAWRELDVVQCGYCQSGQVMSAASLLARNPNPSD
ADIDAAMAGNICRCGTYHRVRAAIKQAAKGA
>F8J9R7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hyphomicrobium sp. (strain MC1)|TrEMBL
MIEITVNGTKHQVDVIPEMPLLWVLRDELGVTSAKYGCGVAQCGACTVHIDGSAVRSCQA
HIGDVAGKAITTIDGVDKGEQHPVLQAWIEHQVPQCGYCQTGQIMQAISLLELIPKPTDE
DINEVMSGNLCRCGTYPRIRAAIHSAAAKMAEK
>A0A6J4UEW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thermomicrobiales bacterium|TrEMBL
AHRRVPRSRFRRPDRERHRPRPPARTAAHLARRTSPRPRPDRGEKGLRHGQLRRLHGAAR
WTRRLRLPPPGRGLRGAVRDHGRGAGEGRRTRPGATGVRRRRRVPMRLLHPRSGDERACP
ARREPRPDRRRHPARRLRQPLPLRRLPQHPRRGPHRRRPGSARPRQRRFRCRRRPV
>A0A7W8T3X4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. MM5384-R2|TrEMBL
MGEIVNLSRRGVLKGTLAGGVVLGLQIGGAGTALAASVLSSANGAKGAFAPNVYVSVAPS
GEIILVVHRSEMGTGIRTSLAMILADELDADWNAVKVVQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGTARQMLVAAAAVQWRVAPATCHTEPGHVVHAASGRRVAYGALATAAARQPV
PGRDTLHLKDEGTWRYIGKSLPIVDLDDIVHGRATYGIDVVLPRMMYASIERSAVYGATL
KSVDSTETMKVPGVLHVVRIPAAPLPAGFQPLGGIAVVATSTWAAMQGRRKLRLDWDLGP
NASYDSQAYRKALEDTARQPGKIVRNNGDTAAALKSAAHHVSADYYVPHLAHAAMEPLAA
TASYANGAVEVWTATQNPQQARTTVAQVLGVKEPAVTINVTLLGGGFGRKSKPDYVAEAA
FLSREVGAPVKLTWTREDDVHNDYFHAVCAQHMEGGLDAQGKTVAWLHRTVFPSISSTFK
ADVRYGAAGELGQGVTDMPYDIANVRCENGAASAHTRIGWYRSVYNIPHGFALGSFVDEL
AAAARQDPVQHLLTLLGTPRHVDLHALGVDYPNYGASIDEYPIDTARYAAVVRAAAVRSG
WSTALPARHGRGIAVHRSFLSYVAAVAHVQVADDGSVRVTRVDLAVDCGRIVNPDRVVAQ
FEGAVVMALGNTLYSELTFRNGASEQSNFTDYQVARIDSVPETHVYIVPSDAPPGGVGEP
GVPPTSAAICNAIFDATGQRIRALPVDTSLLKRT
>A0A080M4U5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Accumulibacter sp. SK-02|TrEMBL
MDTTIATPLAAADPATHATNAPPAIENASRRQFVQGVTGLTLAFCLPASATLAAPAGAGK
LAATGGAAAPPFEPNAFLRIGADDTVTVISKHLEMGQGTYTGLATIVAEELDADWAKVRI
EGAPADAKRYNNLFWGPAQGTGGSTAMANSWEQLRNAGAAGRAMLVQAAAKKWKVPAAEI
TVKDGVVMHAASKRKERFGELVADAAKEAVPTGVTLKDPKDFRLVGKHAPRKDSADKTTG
RAMFTQDMQMHGMLVAMVAHPPRFGAKVQRFDATRAKAIKGVVDVVEIPSGVAVLALDTW
TAKKARDTLTVEWNDTNAFRLGSEEILARYKEMAKRPGLVAHQAGDTDAAFAKAAKKLSA
SYDFPYLAHAAMEPMNCVVARTETGCEVWNGEQLHTGDQYALAVVFGFKPEQVTIHMLYA
GGSFGRRANTKSDYVVEAAQIVKASGTKAPVKLVWTREDDMRAGYYRPLFHHALEAALDA
EGRLTGWRHRLVGQSILKGSPFESMMVKNGIDAVSVEGAANLPYAIPNMTVDLHTPDDIQ
VPVLWWRSVGSSHTAYSTEVFLDQVARAAGKDPVAMRMDLLDKHPRHRGVLKLAAEKAGW
GKPLAAGAPGTRRGRGVAVHESFNSYVAQVAEVTVDAEGKLKVDRVVCAVDCGIAINPDN
VRAQVEGAVGFALSAALHGEIELKDGQVVPGNFDAYPVLRIAEMPKVEVHIVPSAEKPTG
IGEPGVPPLAPAVANAIAAATGKVPTRLPFSADDLKA
>A0A1J5TRQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MKNTTLQDSSRRAFLRDSAVLMGGLVIGFYLPVKGGRAYAAEAQPKAVFPPNAFIRIAAD
NSITIIVNKSEMGQGVYTSLPMLIAEELEADWSSIRIESAPVAAVYNHTGFGMQLTGGSS
SVPSSWEQLRRVGASGRIMLVRAAAGQWGVPESECHAENSQVIHAKSGKRASYGELADAA
ARLPLPDNVELKLPKDFKLIGKPVKRLDTPVKINGSAQFGLDVYLPGMLTVLIARSPVFG
GKVKRYDATEAAKVPGVQGIYQVPSGIAVAASGFWPAGTARDLLEIEWDEGPGAALSTPK
MQTEYLELAKQPGTVARKDGDTAQGFKDAHKSVSAEYVVPYLAHATMEPLNVVVDLTPDH
CTIWTGTQAQTMDRGMAAATAGLKPEQVEIHTMYLGGGFGRRANPRSDFVQEAVQVAKVI
GKPIKVVWAREDDMRGGYYRPMWADRIEAGIAKDGRPLAWKHTIVGQSITADTMFESFMI
KNGIDATSVEGASTLPYLIPNLQVELHSPKNVVPVQWWRSVGHSHTAFVVETMIDELAHL
AGKDPVAYRLDILPATSRYRGALNLAAEKSGWGKKKLPAGHAYGVAVHQSFESYVAEIAE
VSLENGKIRVHRVVAAVDCGMVVNPDGVQQQVEGAIVYGLSAALHGAITLENGRVMQSNF
DSYAPLRFSEMPQVDVHIVASNERPTGIGEPGTPPIAPAVANAVFALTGKRLRRMPFDQE
TLA
>G8Q266|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas ogarae (strain DSM 112162 / CECT 30235 / F113)|TrEMBL
MITLKLNGKDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVKGQDISTIDGLHTDPVGQIVQKAWLETAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNLCRCGTYNRIKTAIRQASTHLKEAKA
>A0A1J5PA63|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MAAAALLKKNPKPTDKDIDEAMTNICRCGTYQRIREAVHMAAGAGTTGRSGG
>H0TPN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MIKITINGQEQTWDGDPELPLLWYLRDEAGLTGTKFGCGQALCGACTVLVDKDAVRSCIT
SVADVAGRKITTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLMDNPKPSHD
QIREAMSGNICRCGCYQRIENAVHLASTGV
>S6D660|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus 386B|TrEMBL
MIKFKLNGRDVSVDVPEDTPLLWALRDDLDQTGTKFGCGVGQCGACTVLVGGRATRSCIT
PISSIEGADVTTIEGLHPEGKHPVQEAWKDIQVPQCGYCQSGQIMQAVSLLKDYPDPTDE
QIDGVMGGSLCRCMTYVRIRKAIKKAAAAMQKEEASHG
>A0A2R8AAM1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pontivivens insulae|TrEMBL
MARKKKSLFGKIVRRTFLTAGAVAVGGVAFGAYLVNRDHDNPLVAGEGEGVFNPFVKIAT
DGTITVITPRAEMGQGIHTTLAAMVAEELDVPLSSITTEHGPTAAAYYNAGMMEEGAFPP
AFHSGLGADAQRSLMASMGKVLGLQVTGGSSSVIDGFDKMREAGAEARAALVTAAANRWS
VSPDVLQTENGSVIYAAGEQSATYGELVLEAAEVEVEEIPALKSRRDWAVLGKRQMRTDI
AEKVTGAPIYGIDVQLPDMLYGTVKISPRFGAAAVSFDDTAARAVPGVLDIVEIETTTGK
GFGIIATNTWAAFKGAEALQVEWGDAPYPADDAGITNRLVAAIEAEGTQSLMDRGDVDAA
FADPQGTIIEAEYSVPYLAHATMEPMNATAQLTEEGLTIWAGTQAPGIVQSRCAALAGLD
KDNVTVNTVFLGGGFGRRGEVDFPLYATALAMQTDGKPIKVTWTREEDTTHDTYRPAAMA
RMRAVVPEGARADAVEMKVAAPSIIPSVIARTYPNLSAAGPDKTLTDGAYNQPVNYDNFR
VSGHAADLSIPVGFWRSVGHSYNCFFHEGFMDEQAEAAGMDPLAYRLAVMEGDDRLDPAR
GVLNKVAEMSGWRGSVPQGKGRGLAQSLCFGTWIAMVVQVDATDDIRIEKVWAAADPGTV
MDPRLFRDQVIGGAIYGFSAALGEEINFEDGQVVQQNFWDYSFMNMEQCPEFEIELLQTS
PHIGGAGEVGTPPAVPALANAIYAATGQRLRQMPLSRDVRFLGV
>S9S5G5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger mucosus DSM 16094|TrEMBL
MPTSITVNGTAHEVDLPSEVPLLWVLRDALNLTGTKYGCGVAACGACTVQIDGEAVRSCQ
VPLGDVWGDVTTIEGLGTPESLAAIQQAWVDHQVAQCGYCQSGQIMQAAALLAETPQPSD
DDIDAAMSGNLCRCGTYPRIRAAIKAAAGMES
>A0A7W6Z6T6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MSQGLLDAQNGAQPSKRSKSGITRRTFLKFSVTVGAASGGGLLLGFSMPAASQDQKTGKS
VIGGDGDEAPQNGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVPLDS
VTLDHAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRRAGAAARTLLISAAAQQWQVDPA
SCHAQAGQVIHAASNRSIGYGQLASAAAKLPAPQNVPLKDPKDFKVIGTPVKRLDSPEKV
DGTAMFGLDVRVPDMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQIVKLDNAVAVIGDH
TWAAKRGLQALDIKWNEGAGAQIGMKQIVDDLANASQRNGAVARKEGDVSNAFSNAKTRV
DAVYQQPFLAHATMEPINCTVHVRPDGCDIWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LIGGGFGRRLEFDMVTQSVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDRISAGLDANG
KPVAWQHRIVGSSIMARFAPPAFQHGLDPDAVEVAADLPYDLPNQLVDYVRQEPHAIPTA
FWRGVGPTRGTFVVESFIDELAAQAKVDPVKYRQDLLGKTPRALNVLNTAVQAAGWGSAV
PKGQGRGVSVMHAFGSFFSMVVDVAVDQGEVSVKRVVCAVDCGMVVNPNTIEAQVQGGII
FGITAALYSQITIKDGRVEQNNFTDYRMLRIDQTPPIEVHIVKSSEAPGGIGEPGTAALA
PALTNAIYAATGKRLRQLPVGSQLQTA
>A0A7W8RWK2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MELIVNGVHHNVDADANMPLLWAVRDLLGLHGTKFGCGVGACGACTVHLDGVAVRSCVTA
LADVQGKPVTTIEGLGKGGDHPVQRAWKAANVPQCGYCQPGQIMQAASLLKQTPKPSDEQ
IVEAMSGNVCRCGTYQRIKAAIKAAASEA
>A0A857JI92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola mesophila|TrEMBL
MSTNHDIKSLSRRDFLRYTSVAGGAFVLGTVLPGISPVWAASETDSSSNTLNLFVSIDND
GTVNIVCHRSEMGQGVRTGIPQIVAEELCADWAKVNVVQGLADEAYGSQNTDGSRSIRRF
YTTMREMGATARTMLEQAAAQKWNVPISEVFAENGAIVHQSSGKTLGFGELAKAASAQQV
PQVKTLTFKSPKDFKLIGKPVTSVDLPNVLTGNTVFGQDVQLEGMLYATIERCPVVGGTV
KAYDKDAPLKVANVVDVIEMPKQHFPVLFKNLNGVAVLASNTWSALQGRQTLNIQWELGE
NQRHDSAAYLADLEKRIVTKGKSIRSAGDAYSAFDSANNTMSATYTVPYLVHAPMEPPAA
TAVFKNGQCEVWACTQTPQSTQQNVAGALGIDKSMVKVNVTLLGGGFGRKSKPDFSVEAA
ILAQKTGKPVKVVWSREDDIRHGYYHAISAQHFQAGLDDSGKVTSWVQRTAFPSISWTFT
GTTDEPQNGELSLGFGDLPFDIDNLSCEIHKAPAHVRIGWIRSVSNIQHGFAIGSFVDEV
AAKTGVPTSDMWQTLIGEDRIVDPKTQGFKYENYGESYDNFPIETKRLKNVLNTLLAKSG
ANNATSENEGWGISVHRSFVTYVAVATKVKVENDKVTVLEMHSVIDAGRVVNPDRVKSQQ
EGAMIFGLSIALMGEITIKEGAIEQSNYHDYTVLRMHQSPKIVTHIVESDAAPGGVGEPG
VPPVAASVTNAIYQASGKRIRALPINKHYSV
>A0A379ING8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas mendocina|TrEMBL
MITLNLNGKDHELDVADDMPLLWALRDVANLTGTKYGCGMALCGACTVNVEGQPTRSCVT
PVSAVVGKRISTIEAVGEDAVGKVVQQAWRQLDVVQCGYCQSGQIMAATALLSSNKAPSD
ADIDAAMSGNICRCATYVRIRAAIHEAAGQLA
>E2XQ96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens WH6|TrEMBL
MELRINQKAYQVDADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREITTIEAIEADEVGKRVVSAWVEHQVAQCGYCQSGQVMAATALLKHTPAPTKD
QIDAAMVNLCRCGTYNAIHTAMSDLAAGKETA
>A0A7X5Y4I6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kaistensis|TrEMBL
MKVSRRTLLVGTGAAAGLAVAWSLWPRSEPASLAATDEALALGPGVLIGRDGRLTVAVPQ
VETGQGIWTGLAQIAADELGAAWETVGVAPARSGSRWDNDLAGEQGWLAGARPWPGAPDP
GLLRITAGATSIRALERPMRQAAAAARTLLIAEAASRWGVRAAECDTGGGFVRHEGKSLP
FAALVEGAAARSLPGGDIPLRETPGELAGKPLSRLDAQPKAEGRLRFAGDVRLPGLLHAS
VRGAGRGSVSLDSPPPSGIRFESGTGWVAALADDWWSADRALAAARVRVLGPAGGDDAAV
ASALDLALAGDDYQQLHVLGDIEEVFAGVRPLAATYTAAAQLHADLEPPGATARLNDGLL
ELWAATQAPEVARRAGAEAAGVPLAQTLLYPMPVGGQGGAALEAGMVPVAAALARRTGRP
VQVTASRTEQVRGGAVRSPLKARLFARPMPDGSIAGWRMRLAGGDGTAHAFARLLRTGSG
GPRPSALAPLPYGIPNVALEFAPADLPLRLGYHRGELHPAVTFFTESFLDELARIGGRDP
LSQRMTLLAANPRLARCLVRATALGGWDGGGPGSQMGLCAFSGYGSHIAVVGQAQVGTGG
EVQVSRLVAAVDCGRVVNPALVKAEVEGGMLAAIAQATAAAPSFRHARVLGPLEPLLPTL
AAAPEILVEVLASDAAPGGASGLGSAAAPAAVGNALAAATGRRLRSLPFDPMS
>A0A2X5BP27|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MNIQINGRMIPLDDSLRDTPLLYILRNDLALNGPKYGCGLGECGACTVLIDGVAARSCSV
NAASVVGKSVTTLEGIGNAEHLHPVQQGFIDEQAAQCGYCTNGMIMTLVALFEREPQADE
QTIKQELAFNLCRCGTHIEILRAAERAKQILAERGNA
>A0A160NUB5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces laurentii|TrEMBL
MPQHTFILNGKAVTAEVEDDVRLLWVLRDVLGVTGPKYGCGLGVCQACTSHLNGKAFNPC
TVPVKDLEATDEVTTIEGLPATVGQDLHPMQEAWLDIDVAQCGYCQPGQIMAAVDAVRRA
REAGREVDEADLDQIRNICRCGTYNRIREAIKEGARRMP
>A0A383RUZ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas reidholzensis|TrEMBL
MSVLTINGREYTVDVDPSTPILWTLRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGRKITTIEAATDGSDPVGAAVHEAWVKHDVAQCGYCQSGQIMSATAFLQAQPKG
KQPTAAEIDSAMAGNICRCGTYARIRAAVADAAKVLA
>A0A7X6FFE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MAISATVNGRAVQLDGPPDMPLLWALRDLLGMTGTKFGCGIGQCGACTVQVDGKPVRSCV
LPIGELDGAITTIEGIGETEEGRRIQKAWLSLEVVQCGYCQCGQIMAASALLARDPKPDD
AAIDAAMSGNICRCCTYPRIRDAIKEA
>A0A7X6J6N1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MNLQINSQSYQVTSDGDTPLLWIIRDELGLTGTKYGCGLAQCGACSVLVDGEVVRSCVTP
LDSVVGRQITTIEAIENDPVGKRVVTAWVKHQVPQCGYCQSGQVVAATSLLKETPNPSDE
EIAAAMINLCRCGTYNAIKAAVKDLSSKEGETL
>A0A7W4T245|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas umsongensis|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSSDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A0S4U8H1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MDLDVNRRPVKVECDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VAAVAGRRITTIEGLAEAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADIDAAITNLCRCGTYPRVRSAIKRAAQALREGRA
>A0A7W8SUX8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WSM4180|TrEMBL
MAVLSINGRRVMVDADPDMPLLWVLRGDLGMTGTKFGCGVGICGACTINLDDAACLACQT
PMSSLHTQKITTIEGLQGREAQALKAAWIELDVVQCGYCQSAQLMAACALLKHKPDPTDA
DIDEAMTPVVCRCGTYPRVRAAIHQAAAKVRKS
>A0A7W8SVT5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WSM4180|TrEMBL
MLTRRTFLLGGASALGGLLVGWAVVPPRQRLMTSTPLPTQGTQVALNGWVKIDADNRVTI
MVPKAEMGQGIHTGLAMLLAEELDADWAQVKVEEAPIDRIYNAVQSIVDDLPFRPDDDSY
IRRGTVWITSKAVREIGTMMTGGSSSMNDLWTPMREAGASARVMLIEAAAERWDVPAREC
HVEKGYVLHRWGHKATFGELSSMAARQPLPRSVVLKQPADFKLIGQPVRRIEAASKIDGA
ARFGIDVLPDGLVYASVVMCPTLGGTVAHFDATPAQKMRGFIKAFAVPPYAGGTGGVAVI
ADNAFRAMSAVEAINVTWHDGAAAKVSSAAVDCRLVEALDHTDGHVYYHVGNVDNAMSRA
ARTIEAVYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQMPRLARHHAAKVLGLDVDLVD
VQTQLLGGAFGRRLELDFVAQAAAIAREADGRPVQTIWSRAQDFTHDFYRPACAAWLQAG
FDEHGKLVAWHAKSAGQAIVPDALARYYGVPHIPIDKTTCEGAFDQPYEWPAARVSHKIV
ELPVPIGFWRSVGHSHQAFFTESFTDEAAAAAGQDPIAFRAMLLVQHPRHLAVLKRVEKL
SDWGRPLKPAADGARCAHGVALHEAFGSVVAQVAEVSIGANRQIRVHRVVCVIDCGLPVN
PNLIRQQMEGGIVFGLSSALQNEITIVNGQVQQKNFVDFPVVRMNGCPAIEVDIMPSQLH
PQGVGEPGVPPIAPAVGNAVFALTGQRLRTLPLRLA
>A0A7W5A8I2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides albus|TrEMBL
MPTHTFQLNGETVTVDVEDDVRILWVLRDVLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVRVADLDKNDEITTIEGLADTAPGDGLHPMQEAWLEHDVAQCGYCQPGQIMAAVALVNK
VREEGRAINEADLDTIRNVCRCGTYSRIREAIKTGQEAMARGL
>F6AUS1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Delftia sp. (strain Cs1-4)|TrEMBL
MLTTFNPAELPRALQHILDRDEAAAAIADAPTLAQIPRRSFLKIAGAGSLALGVFPAMAQ
APGKGEATGLKPTEQPASFVEISPNGEVTVAINRLEFGQGVHTALPLVLAEELDADWSKV
RARLGGNDAAYADPRYGIQMTGGSTALKHSYTQYRELGARARAMLVAAAAAQWKVDAATL
RTREGFVLGPNGKKLSYGELAQAAMAQPVPATVVLKNPKDFRLIGKPTGRIDARAKSSGQ
QSFGIDMHLPGQLTAVIAHPPVFKAQLASLDDAAARAVPGVKAVLRVPVDGGGEGVAVIA
TGYWPARKGREALKAQWNTDAVEKVDSERQLAQYRELAAQPGARHFDADISALDKAPRHI
EAEFSFPYLAHAPMEPLNCTVQMGETGEAGADLYLGTQFAGVDGMAAARVLGLKPEQVRV
HVQMAGGGFGRRGVGTSDYVVEACQVALAARRAGLNAPVRMVWSREDDIKGGYYRPMHLH
RAKIGFDERGKVLAWDHAIVGQSITAGTMFEGGMIKNGIDATAVEGMREPYPLPMRLTVH
HPKVNVPVLWWRSVGSTHTAFVMETLIDEIARSSRQDPVAYRMQMFGDKHPRHRLALQLA
VDKSGYGKRQLRAGRAWGVAVHESFDTVVAYVVEASVKDGRPVLHKATAGVHCNLAVNPR
TIEAQVQGAALMGLSMCLPGAAITLKDGVVEQSNFGDFAVPRITDMPEIAVHVVPSAEPP
TGMGEPGLPPLAPAFANAVAQLTGKPVRKLPFDLA
>A0A7W7NVM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium chloroacetimidivorans|TrEMBL
MPRLTVNDHAVEFDMDPMTPLLWGLRDAANLTGTKYGCGVGDCGACMVLIDGEALRSCLV
SLAECEGRSVTTIEGLSRDRSHPVQQAMVAEQAIQCGFCTPGIVIAAAALLARNANPSEA
EIKAAIPNLCRCGVYPRLLRTVQRAGRIMRREETLRAAPEPGIDIEDAARTVPALDATP
>A0A375CBG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSDLHTGRRRFLQAAGAVPAALVLGFHLPLAKAADASAPARDPDDVNAWLRIDADGSVTI
MVPSAELGQGVMTSAPMLVAEELECDWRQVRAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQGWSVPVAQCRAAQGVVRHEPSGRTLGYGALAARAATLPR
PAKVALKDPRDWKLLGRPTDRLDIPLKTRGAAVFGVDVKLPRMLVGSVMACPAFGGTLRR
VDARPALAVRGVRRVVPLADAVVVLADSYWTARKGLAALQPDWQPPPGSLAGDAALMAGY
RDAARRASALALRHGDPEAHMQGAPAYTAEYEVPYLAHATMEPMNASADVRADRAEIWGP
TQVCGEIAQRLSGVLGLPADRIAVHGTFVGGGFGRREEFDVFVQAALASRAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPDGIRALDARLACSSIYVRNFPERVKGGVDPKSVEG
VVDLPYALPHLAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHASTDPLQFRLS
LLAERPRAAHLLRRLAQHVGWGSAPAGRWHGVALSQAWGSLCATVVELSVQDQRITLHRI
VNAIDCGVVINPATVERQLEGASIWALGAALSGAITIADGRVQQSNFHDYPLLQLAQTPR
FEAVLAPGGERIGGVGESAVPTLAPALANALFAATGQRIRSLPLARHGFELA
>A0A375BCX1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLEVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVKAVVGHAVTTLEGLGTAQHPDPVQQAFIEEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVMRAAVLQRQAAQGVAS
>A0A3G7Y922|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R5-89-07|TrEMBL
MNIREILPGVTLDEPINLSRRRFLASTAVGALVIGFGLPLGASRVQAATGTAERGTQVPA
FLEIRPDGSVRLLSPFMEGGQGTHTAMAQIIGEELDADPATFVVEAAPPGEAYVVMENGL
RITGGSMSVRMSYPTMRRLGALARAMLMQAAAEQLGVPVAQLTTQPGRVVHAASGRSLGY
GELAARALDMPVPDPATITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYSIDLKVDGMLHA
AVQHAPRLGMTVGSLRNQAQVEAMKGVHSVHTLPGAVAVVAERWWHAKRAVEAIQVEWLE
AAADSTVRAMPADFSSDKYRDFLAAQQGPARDDETEGDVATSLASAKTRVDATYHNQYLN
HAQLEPPSALARYNPDGTLEVWLPNQAPDMFRADIAKRTGLTIEQITLHSPLLGGFFGRH
FLYDSANPYPQAIVLAKAVGRPVKLIWSREEEFVRDVLRPVAVVKFHAALDDKGLPVAIE
AVSATEGPTEAIAGKQGDALDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGNS
LNDFFYEAFLDELADKGGHDPYELRLHLLRDNARLTTLLQAVGELSGGWKRGPFTAEDGS
RRARGVAMASPFGSHAAVIAEVSIDNGQVKVHDIWQAIDPGSIVNPAIIEAQVNGAVALG
LSQTLLEEAVYVDGKPRARNYDLYPILPPSRMARVHVKIVESGEKMGGIGEPPLPAVAPA
VANAVAQLTGQRIRSLPLSRYTFS
>A0A3G7YB98|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. R5-89-07|TrEMBL
MELRINQQAYQVDADADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAALVGREITTIEAIETDDVGKRVVAAWVERQVAQCGYCQSGQVMAATALLKHTPAPTRE
QINAAMINLCRCGTYNAIHAAMDDLAAGKGSV
>A4AB71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Congregibacter litoralis KT71|TrEMBL
MNLKKLLGETPNTEEQASGVVNISRRRFVVGSATAGAGLMVAMQLPLGSAPAVAQDGATE
VNAWVLIDPDDTVTIRIARAEMGQGTLTGLAQLVAEELECDWDKVSWEFASPAESLARNR
VWGSFATGGSRGIRGSHQYVREGGALARELLLAAAGREWGVPVGECTAKNSVITHTPSGA
TMTYGELAATAATLSAPDAVTLKDPKDWSLVGTPAARLDTRDKVSGKLQYGADVMLPGML
HAAIHACPVHTGKRRSFDDSKAKDMPGVRAVLEVSDNAVAVVADSWWQAKQALDAVSIEW
ETGEDGKVNSESIQAMLEEGLAADDAFVGNEQGDALAALASSDNTLTADYSYPFQNHAPM
EPMNATALWTEARCEAWVPTQNGEAALEAVATAAGLFPEQCEVHRMILGGGFGRRGAHDF
VDQAVAIAKQMPGTPVKLLWSREEDQRRGYYHPITRSRMTAAMDEDGKLDALHMRISGQS
ILAFFRPALGDKPEKDPVVFQSVAPEGDHSMIYSMPNFLADHAMRNTHLRPGFWRGVNIN
QNVFYMESFVDELARKAGVDPLEYRRGLLKESPLALTVLEEVAKKAGWGREMPEGHGLGL
AVCKAFGSYVAACAEAAVVDGKLQMKKIWAATDPGFAVNPQQIEAQVGGSFVYGLSAALY
GECTVEEGRVVEENFDSYPSLKLAEMPEVEVSVMPSGGFWGGVGEPTIAVAAPAVLNAVY
AATGVRIRHLPVKDQTLA
>A0A2R8AI07|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aliiroseovarius pelagivivens|TrEMBL
MKLSVNGVSHEVDVEEDMPLLWVLRDELKLDGPKYGCGVAACGACTVHVDGVAVRSCQTL
VGDVDGPVTTIEGLGNPDEMHAVQAAWLTHQVAQCGYCQGGQMMQAADLLTNNPNPTDED
IDDAMSGNLCRCGTYPRIRDAVKTAAKNLQVV
>A0A3G7K491|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MSKLKTLVGWSLTALSLAVTAGVFISWQPAIAPLDNHDTQYFSHAQVAKGEQLAALGDCA
VCHTAPGGARNAGGLAMRIPFGTLYSTNITPDPETGIGSWSYPAFERAMRHGIDRNGRYL
YPAFPYTAFTKTRDEDLKALYAYLMSQPPVRHQPPQTDLHFPFNIRPGILAWNWLYLRPG
ALADDPGRSALWNRGAYLSEGLGHCSACHSPRDPLFGERGGRRHLSGGVAEDWSAHALAG
SKAPLAWTEQDLLDFLRHGYSPRHGVAAGPMAPVIHEGLAQLPEADLQAIAHYLSSLQPA
STTQASADTLNHQAEQRTEPLGSPGARLFSGACMACHAQEKGPTLTGVRPSLALNSNLYA
DSPDNAIRVILEGIAQPANPELGYMPAFRHSLDDQQIAELLTFLRQDLASQAPWKDVKQR
VSHIRASLPPG
>A0A3G7K387|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MNDLPLTRRRLLQAGGLIMISTLLPKPLLAMAETRTTTPLPADPTPDHVDSFIALGADGH
VTAFCGHVDLGTGVRTALAQIVADELDVDFEQVRMILGDTASTPDQGPTIASATLQVSAL
PLRQAAAQLRQWLLEGAAEILDQPIAGLRVERGQIYTSARPKRRLSYAELALGQDLHLPL
DPHVKLKTVGAGRYVGQSTPRVDIPAKVSGQLTYVHDLRLDGMLHGRVVRPPYPGADASA
PLGHALISVDAASIAHLPGIVRLVVIGDFVGIVAEREEQAIDAMRQLKVQWKTWDALPDL
RQDALHKTLLAHPKQDRVLRDDPGIDSSLGTLNSPLNVDYVWPYHLHASIGPSCAVAMID
AERAEVWTGSQNPHDLRKDIALLLGRAPQQVQINRMEASGCYGRNCADDVAADAALLSQA
VGRPVRVQLMREQEAGWEPKGTAQLMQVRGGLDGKREVVAYELKTCYPSNNARTLALLLT
GTVANRPDIQQMGDRTAIPQYRFPQMRIVCQDAAPIVRASWMRGVSALPNVFAHESWIDE
LAYIAQQDPIAFRLRYLDDPRALALIEALKKQADWQDGSAHRHPAPPSQEWVKGRGFAYA
RYFHSKFPGFGAAWAAWVCDLSVNRRTGQIRLDKIFVSHDCGRMVNPAGVRHQVHGNIVQ
SCSRVLKEYVGFDHCGSTSLEWGGYPILRFDELPEVDVQLLDRPEEPSMGAGESASVPSA
AAIANAIFDAVGVRLRQVPFTPERLLQALQQTPDADRTGQEAHP
>A0A1Y6KM17|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MTERLTPTADDPRGMLSIERRVADGSSETFIRITAAGEVSAFNGHVDLGTGIRTALGQIV
AEELDVSFARVVVVLGDTAVVPNQGATIASETIQITAVPLRKAAAQARAFLLARAAVQLG
LAVEDLTVEDGLVRGPNNRVLSYGELIGNDTIRLELAEDVAVKSVDNYQVVGRSVPRVDL
PAKATGEPTYVHDVRVPGMLHGRVVRPPYVGVDAGPFIGTSLIGVDKDSVRDVSGLVDIV
VIGDFIGVVAEREEQAILAAERLQVNWKPVPTLRDLDDVENALRANPSEPRRLLDKGNVD
AAIEGAAKPMRRTYLWPYQMHGSIGPSCAVADVRDGHIRIYSGTQNPHLLRADLAKLIDC
PEHQIELIRLEAAGCYGRNCADDVTADALLLSRAVGRPVRVQLTREQEHVWEPKGTAQLM
DVNGGLNADGSVAAYEFATRYPSNGAPTLALLLTGRIAPEPAVFEMGDRTAIPPYDYDHM
RVTAHDMPPIVRASWIRGVSALPNTFAHESYIDELAAEAEVDPIEYRLRYLKDERARDLV
NAVAERASWTPRPVRQEKTPENGVVHGRGFAYALYVHSKFPGYGAAWSAWIADVAVNTTT
GDVSVTRVIAGQDSGLMINPDGVRHQIEGNVIQSTSRALMEEVPFSRGKVAAREWGAYPI
ITFPDVPKIDVLMLPRPDQPPLGVGESASVPSAAAIANAVYDATGVRFREPPFTPERILK
GLRGEQLEPAKPQPLPAPDKPAATWIKPFARRGGLIASAVAACAAAIGVATAVLPWRAIA
PITRPDPSVYSAATIARGESLAALGNCAVCHTSDGGLINAGGRALETPFGTIFSTNITPD
VETGIGAWSYPAFERAMREGVHRDGRQLYPAFPYTHFARTSDADLQALYAYLMAQSPVRQ
QTPDNALRFPFNLRPLVAGWNALFHSTETFKPDPTRSEQWNRGFYLVESLGHCSACHSPR
NALGAEQRDAYLAGGFADGWEAPALTALSSAPIPWTEDELAIYLRTGQSRFHGVTAGPMA
PIVKDLATLPDADIRAMATYLASFQQTAPEPAKLEAIARELETRTKVTSASSPAARLYLG
ACAVCHEVGGLPLFGSRPSLALNSNLHSATPDNLIQVILHGIMKPASSDLGYMPAFKDHL
SDAQLAELVSYLRGQFAPDKPAWTDVDAAVSRIRSATPH
>A0A388RH15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MNTPRPLTLQVNHAEHTLSVAPDTPLLYILRNDLACNGPKYGCGLGQCGACTVLVDGRPA
RSCVLPVRAAVGHAVTTLEGLGTAEHPDPVQQAFIDEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVQRAAVLMRRAAEGATS
>A0A1X6Z3C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudooceanicola marinus|TrEMBL
MKIGFTVNGTPQEVDVAADMPLLWVLRDVLGLTGTKYGCGAALCGACTVHMDGEAVRSCQ
VWAEDVAGREVLTIEGLGRPEALHAVQEAWVEQQVAQCGYCQSGQIMQAAALLAKTPAPS
DAQIDAAMEGNLCRCGTYPRIRAAIHAAAAKLEG
>D5RJM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseomonas cervicalis ATCC 49957|TrEMBL
AAPRPGSRVAAFLEIRPDNTVLLKSPFIEGGQGVDTAMAQILGEELDVEPARFTVECAPP
GADYALVNGMRITGGSYSVRSAYPVLRQLGARARQMLLQAAAARLGVAADSLATEPGRVI
HAASGRSLAYGALAAEAASLPVPESAPLRAERDFRWIGKPVARLDVRAKSTGQAVYAIDL
TVEGMLQAAVQHAPRLGQEPRALANEAEVRAMPGVHSIHRLPGAVAVLADRWWRARRAVE
ALQVDWAEPAAGARRAMPADFSSNAMREALAKARGNALPAESHGDAEAALKTATRTLEAQ
YDAPYLAHGQLEPPSAIAHWKGDGTLELWLPNQAPEMFQRAAARVAGIAPEKVVIHSPLL
GGFFGRHFLYDNANPFPQAILLSKAVGRPVKLIWSREEEFLRDALRPMGLARFRAGLGPD
GLPVAFAAEAVGEGPVGRYFGGQPGRADPSAVEGISEKPYAIPNRLVVQVPHAHPAIIGF
WRSVGHSMNDFFYEAFLDEIAEAGGQDPYALRLRLLADKPRHKALLEAVGELSGGWRRGP
YDAPDGTRRARGVAMASPFGSEVATIAEVSLREGEVVVHEVWVAVDPGRMVNPAIIEAQV
NSAVALGLSSALLEEVVYENGIPQARNFDGYPILPPGRMPRVQVRIIESGAPMGGIGEPG
LPGVPPAVVNAVAALTGQRIRSLPLSKARLGAA
>Q1LQU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)|TrEMBL
MTSLTINGKTVEVDADPSTPLLWALRDNLGMTGTKFGCGMASCGACTVHINGTATRSCVM
PISGTAGSKITTIEAMGDDKVGRAVLAAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRPTD
ADIDQAMAGNVCRCGTYQRIRAAIKDAAHAIA
>W0PA14|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Advenella mimigardefordensis (strain DSM 17166 / LMG 22922 / DPN7)|TrEMBL
MNVRVNASAIATADVQISNISRRRMLKSFALGGLVLAVGTPLRVFAEGEEQKGPPKYGAD
GMPHGTVDNPLVFVAIAADGAVTILCHRAEMGQGVRTSLPMVVADEMDADWGRVTVKQAW
ADEARFGNQDTDGSRSTRHFFMPLRRVGAAARAMLISAAASQWNVPESEVQAKNHELIHT
PSGKKLGFGDVAQKAAQLEVPAADALKLKTADAFRYIGKGQTHIADGMDIVTGRAKYGQD
IRFDDMLYAVVARPPVFGGKLIKVDDTDALKVPGVVKVVTLAGSPPPAMFNPLGGVAVIA
TNTWAAIAGRRALKIEWDGGPHASYDSAQYRKQLEASVSKPTEKAARNDGDTMAALGSAA
KRIQAEYYVPHLAQAPMETPVATVRIVDGKCEAWASVQAPQATHDMLVKWLELSPENVKV
NQTLLGGGFGRKSKPDFVVEAGLLSKAMDGKPVKVTWTREDDIQHSYYHTVSVEHLEAGL
DAQGKVTAWLHRSAAPSISSTFADSTKQSASELGMGAANVPFAIPNVRVENPEAVAHTRI
GWFRSVSNIPRAFAVQSFVAEMAADQGKDHRDFLLDLIGPARRIDPAALSDGWNHGESPE
LYPVDTGRLRNVIETVTREAGWGKSAEKGQAMGLAAHYSFVTYVATVVHVHVSENGDLSI
PRVDVAVDCGPQVNPERIRAQIEGATVMGVSLATLGEISFKDGAAVQSNFHDYRITSMMS
APREIHVHLVAASDYDAPLGGVGEPGTPPVSAALCNAIFAATGKRIRSLPIANQLQQKT
>A0A0Q0H6L3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella sp. P1-14-1|TrEMBL
MTTFTAVENISRRNVLKMFGAVGGGLALGASGLAWSPMAIAQEAIAQGKQAQLNIFIAIG
EDNKVYLTCHRSEMGQGIRTGVPQVLADELEADWDQIVVVQGLADEEFGSQNTDGSRSIR
KHYQKMRQMGATARSMLEQAAANQWQVSPSDVYAKAGKVHHKTNGKSLSFGELAIAASAL
PTPALDSVTLKPASKFTHIGKSPTIVDMDDMLNGKAEYGFDVKVAGMVHASITRPPVLGS
DVATLDDSAARQIAGVLDVVQIPISKGAPLFQPLGGVAVIATNSWSALQGRKALNITWTE
SANSQYDSEADLAVLVKRVGEPGTVIRQLGDSVTDWSDDNSLSAVYTVPYLTHAMMEPPA
AAASVTKDGCELWASTQTPQSTQKNVAGVLGLKDEQVKVNVTLLGGGFGRKSKPDFSAEA
AWLSQKIAKPVKLLWSREDEIQNGYYHAISAQHYQAKLDGNKAPTALLARTGFPSISSTF
AEGVDMPSAGELDLGFSDMPFNLSQIQLESVKATAHSRIGWMRSVCNIQHGFGVGSFVDE
LAVNAGKPCINMWRELLGKPRQEKLENQVVKYGNYGETLEDFPIDIGRYLGVIDAVEKAM
AKQPKIKANQGWGFAVHRSFVSYVAVATLVEMDGDKLKVLKSIAAIDAGTVVNPDRVHSQ
TEGAIIFGLSLAMMGEISYKDGKVEQSNFHNYPLLRIGQSPEIETIIVESDAKPAGVGEP
GVPPVAPSLTNAIFAASGKRYRDLPLSKVLKM
>A0A7W7AJR5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas abaci|TrEMBL
MIDRRRLLIGGGAGLGLTVAWGLWPRDYPAALPTLPGEQAFGGWLTIASDGRVMVALPQT
EMGQGSWTGLAQIVADELGADWRTVGAFPAPITPFYANPVGLDSLLEGMPAALPDAWRGG
GGVDPAPMLTAGSSSIRMFEEPARAAAATARALLIQAAAARWSVAAADCTTRDGFVVHGA
QRLRFADLAAAAAHQAPPAEPPIGQGGAGRLMGQPLPRLDSPAKVDGSANFTADIRLPDM
AHAAIRQGPIGDSHLVAIDRAAGEAVRGIVAIVEEPDTDRPRWVAAVAATGWAAQRALDA
LRPRFATTGPRIDDDAIATALARALADTGRRIAGEGDPDDGPAAARTLTAEYRVAAGVHA
AIETTAAVAAFADGQLQCWVQTQAPGLARRAAAQAAGLSERQVVIHAMPVGGGFGAGLDH
AVVAQATVLAMRLKRPVNLVWSRGETLLHDRYRPPAAARMTARLGAGGAILGWRARIATP
PVGAGLVERLRPGGLSALAMRLDPADRYAVAGGAPPYRLPAWAVDHHVAELPLPTGHLRG
GAHGYSCFFTESFLDEIAHEAGVEPLSWRIGMLGQNPRLARCLSTAASLGGWEGGIAGSG
QGIAAHAFRDSTIAVMAEAHWREGRPVVDRLVAAVDCGRIVNPDLVRQQIEGGLIFGLAH
ALGAATGFDRNLATVRGFDRLGLPRLADTPDLTVELIRSDEAPGGVSELAVPPVAPAIAN
ALAASTGLRARTLPLRSEG
>A0A0L6CVU8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius tolerans|TrEMBL
MGRVKTIARRTFLIGSVAIAGGVAFGLWRYKTPYANPLLADLPEGAAALTPYVRITADTI
TLITPRADKGQGAVSVQAALIAEELDVSLDQIATDFGPPSPAYYNTALAGDAVPFRATND
SWLAETVRDLADAPMKFLGMQITGGSTTVPDGYDKLRHAGAVARETLKATAARLHGVERS
ALSTETGAVILPDGTRLSYQSLASEAAQTDPITDVTLRDPSEWRLLGKPMQRIDIVPKST
GTQGYGIDIDLPEMLHAAIRLNPGQGAALIGYDASEAEAMRGVQKIVEIPGGIAVIADNT
WRAIRAAEAITCDWAAAPYPADMADHWQALADSFTSDAQDSQFRDEGDVEAALAGGAEIE
VEYRAPYLAHAPLEPLNATVRYTPERIDIWTGTQVPRFIETNVARITGIDRDHIHVHAEM
IGGSFGHRLEDDVVRHATHIAMEMPGRPVKLTYSREEDMAHDFPRQIAMARGRGRVENGR
VTAYDLGIAMPSVLSSQMGRQNIPAPGPDLQIVAGAWDQPFAIPDYRVTGYRAPELAPIS
SWRSVGASSNGFFHDCLLDELIHAAGADPLQERLRLCNHAPSRAVLEAVGEMSNWGSAMA
PGAGRGVAYCLSFGVPCAQVVEVSDTGDGIRLDKVYVAADVGRIIDPVNFDGLVKGGVIF
GLGHAMNCQVTYADGAAEQRNFDQYQGMRLYQCPEIEVRGLETADKIRGIGEPPVPPAPA
ALANAIFAATGTRLREMPFDKHVTFA
>A0A846UGK9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MSAQIGRRSLLLSALAGGGALLVGWSALPPRSRTGSSDPLPAADGSVTLNGWIRIEPDGL
VQLAMNRSEMGQGVHTALAMLVADEMDTPLSRVKLVQAAPQSLYGNVAMFVGALPFHPDD
TEPGRETTTVKAGQWMVSKFARELGVSVTGGSSSIADAWDVLRLAAATARAQLLGAASLQ
WKLPRAELQVHGGIVSHVSGPHAHFGELAKLAAATPVGDVRTKDPKDWTLIGTAAPRTDL
AAKVNGSARFGLDTREPGQLYAVVRHCPMLGGSPQRVKVDAAMQLPGVQRVVRLGPYAGS
TAAVAVVGRSTWHAQRGAQALEIDWAAPPAGAADTKRIDEALEQAAREAAHTDGGFAFHT
RGDVKQARAGAARQIESLYRAPYLAHAPMEPINCTARVHDGGVELWVPTQVPDMARAIAA
RVAGVPLEAVTLHVSYLGGGFGRRLDVDFVAQAVRIAIECGGHPVQLVWPREEDIAHDFY
RPAGVALMQASLDGKGMVSGLTITAAGDAITPRWIERVLPSLAGPVDTPDKSAAEGLYDL
PYGISHQRIAQVATHSGVPVGYWRSVGHSHHAFFSECFIDELAEAAGQDPVTFRLGLLGD
MPRHAAVLKLAAAKAGWGRPLPVGQARGVALHESFGSIVAQVMEVSLADGRPRIHRVVCA
ADIGTVVNPGIVAQQMESAVVFGLSAALYGRIDIDGGAVRQRNFPDYKLLTLADCPRIET
HLVPSTRAPGGMGEPGTPPAAPALANALYALTGRRQRALPLS
>A0A840AWW3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus rigui|TrEMBL
MTKFTVNDRPVQYKMDPQTPLLWALRDASNLTGTKYGCGNGDCGACIVEVDGEAIRSCLV
TIAEAEGRFVTTIEGLRRDRSHPLQQAFVASNVPQCGFCIPGIIMAGAVLLKKSNNPTDE
EIDAAITNVCRCGVYPRLRDAIKRAGRVMRGEERIAAAPPPGITPEDAARAVPALTVTD
>A0A846UDC8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MTQPTDLTRRGFLQSSALTSGGLMLGIALPGAVSDANAAGMLYTPNAWVHIADDNTITLL
SARSEMGQGVYTSMPMLIAEELDVDIRAIKVSIAPPNQKLYGNALLGGPQLTGGSSSVRD
GWEKLRIAGAQVRMMLISAAAQKWNIPESQLRAENGRIVGPKGRKATYGQLAAAASKLPV
PDKVVLKDPKDFKIVGKPTRRLDTPAKVNGTAEFGIDVKLPGMVYASLEQCPVIGGTVKS
FDAGKAKAMPGVIDVVQIPDGVAIVADTWWHARKAREGLAVVWDEGPGAALTHTAMTEGT
RAALSSGKVLPLKAVGDADAEIAKVEKASGKVIRAEYMMPLLSHSPLEPMNFTAHVHDNR
VDLIGPTQWQDAAAATVAKVVGVPPENVSLRTTFLGGGFGRRIDIDFIIQAAQISKAVRK
PVKLLWTREDDMTHDFYRPQSVHQLAAAIGPDGKPTAMTFRMSSQSVTGRVFGLPADVQD
PLMTEAAVAGYAVPASRHDIVKHDAGLRVGYWRSVSHALNAFANETFIDELAVAAGQDPL
AYRMSLLAGQPRFANVLKIATDRAGWASAAPAGRFRGIALMEGYDTYMAQVAEISVANGE
VQVHKVTVAADLGRMVNPDTVEAQIQSSIVFGLTAALFGEITLEKGRVQQTNFHQYRLLR
LNEAPAIDITLVPSTEKPGGIGEPATALIGPAVGNAVFAATGKRLRRMPFTPENIQSA
>A0A1M4EC90|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea gerenzanensis|TrEMBL
MPGEPIGRRRFLGYVVAAPTLVAAAELTPPSPPGEAGEAALPSPELTELTELTELIDLND
VMTAAALPTSGLISVEIGRDGTVSFALPRAEVGQGITTSSAMLIAEELAVPLDRVRVTLA
DARPELLFNQLTGASNTTISTYVPIRVAAAVARLRLLEAAAAELGAPIGDLSLDAGVISD
RSGRSVGIGALAERAASSRTRQVAVTLAPRAGFTVIGRPHNRVDALAAVTGRKRFTMDLD
VPGALPTMVCRPPAINGKVGSVANLAEVRAMPGVTDAVVISTGVAVRAETFGQCIDAVRA
LKVTWKPGTAAGKSDESVLRALQAAELPLGLRPPTPVVEGAFTFYFRGNSALEPNCAIAD
VRADRAEIWSALKSPIVAQQSIAAKLGLPVGEVTVHVTEGGGSFGRKLFFDAALEAAEVS
KKLGKPVKLMWHRADDARQGRAHPMATSRVRVSYLGGTVLSYRQRHTSVSTDLGHGLGEI
FTALAARLPVGDIGFSQTFFHLSQTMSYDFGAGSQLLAETDKSFNTGSMRNVYSPDVTCA
RELIVDRLAARMGKDPYRFRHDFLRDDRSRAVLAEVAEAGAWGRAMAPGTAQGIAFHAEY
KSVSAALVEIDCRPETVNRPIRDGVTGPRVTKVVFAVDVGLPVNPRGLEAQMMGGVSDGI
ALALTSSLHLRDGYFLEASWDDYFYTRQWNTPLDLRIIVMPATSDEPGGAGELGVAASMA
AVACAYGRATGTMPTSFPINHGTLSFTPKPTVPPVPPSPTDGLDHAR
>A0A0E0ULW7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium meliloti (strain BL225C)|TrEMBL
MELTINGSRHQVDIEPDTPLLWVLRDELGMTGTKYGCGLAQCGACTVLVDGQATRSCVTA
VESVAGSEIMTIEAITEDPVGQKVVEAWVSNQVPQCGYCQSGQVMAATALIKQSPRPSDE
DIAGAMINLCRCGTYNAIAAAVRQAAEA
>A0A5M9IZN2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas extremaustralis|TrEMBL
MNTRYELPDLSLSEPINLSRRRFLASTAVGALVIGFGLPLGSARVQAAATAERGTQVPAF
LEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAYVVMENGMR
ITGGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPLAELTTQPGHVVHAGSGRSLGYG
ELASRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYSIDMKVDGMLHAA
VQHAPRLGMSVGGLRNQAQVEAMKGVHSVHQLPGAVAVVAERWWHAKRAVEAIQVDWQEA
AADASVRVMPANFSSDTYRDFLAAQQGPARDDENQGDVAAALAGAKTQVEATYHNQYVNH
AQLEPPSALARFNPDGTLDIWLPNQAPDLFRADIAKRAGLDPSKINLHSPLLGGFFGRHF
LYDSASPYPQAIALAKAVGRPIKLIWSREEEFLRDVLRPVAVVKFRAALDAEGLPVAIEA
VSATEGPTEAIAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGNSL
NDFFYEAFLDELADKGGRDPFELRLHLLRDNPRLTTLLNAVGELSGGWKRGPYTAEDGTR
RARGVAMASPFGSHAAVIAEVSIDKGQVKVHQIWEAIDPGSIVNPAIIEAQVNGAVALGL
SQTLLEEAVYVDGKPRARNYDLYPILPPSRMAQVHVKIVESGEKMGGIGEPPLPAVAPAV
ANAVAQLTGQRIRSLPLSRYTFS
>A0A0H3KLW4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MVTLNINNRRAEVDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPVHSCTL
ALSSVGSARITTSEHLADDAVGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRSNKAPSD
ADIDSAMAGNLCRCATYQRIRAAIHDAARALA
>A0A0H3KEP0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MNLDVNRQAVNIDCDPSTPLLWVLRDHLNLTGTKFGCGVAACGACTVHLDGAAVRSCVLP
VAAVAGKRITTIEGLAESPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPTD
ADIDAAITNLCRCGTYPRVRTAIKRAAKALREGRA
>A0A347WE17|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Komagataeibacter saccharivorans|TrEMBL
MTTFRLNGRDVTVDVPDDTPLLWVIRDEVGLTGTKFGCGIGMCGACTIHIGGRATRSCVT
PVSAAEGADITTIEGVDPEGNHPVQQAWRDIQVPQCGYCQSGQIMQAISLLKDYPSPTDE
EIDAVMAGSLCRCMTYVRIREAIKKAAANARGDSSNG
>A0A2H6A438|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR33|TrEMBL
MASLVQTRREFLKTGAAAGATLIIGFYLPVPGRRGSTATSFKPNAWLEVHSDGSVTIWTG
RSEMGQGVRTAMPMIVAEELEADWQKVTVVQADANPAYGDQVTVGSRSVRSGFEPLRKAG
AAAREMLISAAALTWNVPREQCRARAGFVEHIPSGRRAGYGELVARAAELPVPQDPPLKP
ASEFRLLGKRVPRVDTIEKVTGRAVFGIDVRTPGMVFAAVARSPVFGGRLKRCDPSAALR
VPGVQRVVEISTGVAVVAENTWAAFQGKRALVCEWDEGEVAAWDSEKISQAFARAAGRSG
ETVRSEGDAERALAGAARSLEAVYEVPYLAHACMEPMNCTADVREDRCEIWAPTQSPQGA
QREASRISGLPVEKITVHVTYLGGGFGRRGSADYVAEAVELSQKVGRPVQLVWTREDDIQ
NALYRPATYNVLRAGLDQAGFPIAWYHRLVAPRGAAYMITRGADELVYDIPHFKLERVVE
DPGIPVTAWRAVAPSQNGFIVESFIDELAHAAGEDPYRFRRKLLPERSRLVQVLDLAARR
ASWGSPLPEGHGRGIALWQFGETYVAQVAEVSVDGEGAVRVHRVVCALDCGAIVNPDTIE
AQTEGNIAYGLTAALYGAITIDRGRVVQSNFHDYRILRISEMPEVEVHLIRTDAPPGGVG
EAALPPIAPAVTNAIFAATGKRVRKLPIGRLS
>C7DE96|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassobium sp. R2A62|TrEMBL
MQLTVNGTEHDVDVEPEMPLLWVLRDELNITGPKYGCGIAQCGACTVHIDGMAVRSCQLA
VGDVAGGVITTIEGLGQPESLHAVQEAWIENQVAQCGYCQSGQIMQAASFLDFNPAPTDD
DIDAAMSGNLCRCGTYPRIRAAVHAAAKKMQEV
>A0A840HMQ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ERR14|TrEMBL
MNKHISPRLNRRAFVIGSATLGAGLAIGLDLPFGGPAVVRAADGSPEIGAWVVVRPDDTV
VIRIARSEMGQGSLTGLAQLVAEELECDWTKVTTEYPTPGQSVARKRVWGDFSTGGSRGI
RSSQDYVRKGGATARVMLIQAAADAWKVPASECAAANSVITHTPSGRTTTYGKVAEAAAK
LSPPAEVKLKDPKDWKLIGKGVKRLDTVDKTTGAMIYGADIKLPGMLNAAIKDCPVFGGK
LKSFDEAKIASMKGVKKVVKVGDTAVAVVADTWWHAKTALEALPIVWDEGDNAKVSSESI
AKWLAEGLNNDQPAYVGNRNGDAKAAIAGAAKKVEAVYSYPYQNHATMEPMNATALYTAD
KCEVWCGTQNGEAAFAAVLEASGLPADKCDVHKVMLGGGFGRRGQTDYVRQAVMIAKEMP
GTPVKLLWSREEDMAHGRYHPITQCKMTGAFDANNNLVALHYRLSGQSILFSLRPEALQN
GMDPAAFQGVAQSGEAAFGYSVPNLLVEHAMRNPHVPPGFWRGVNVNHNAIYMECFMDEL
AQAAGQDPLEFRRKLMGNHPKHLAVLNAVAEKIGWTTPAPQGVYRGIAQVMGYGSYVAGA
AEISVTDGSKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGKIEQ
TNFDTYNSMRINEMPKVESVMVPSGGFWGGVGEPTIGVAAPAVLNAYFAATGKRIRSVPL
RDQNITFA
>A0A238JDD5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas phthalicica|TrEMBL
MTLKTSRRGFLKSAAAAGAVLMVGLRPDGALAAGSETAQLNPFVKINDQGRVVAIIKHFE
KGQGPATGLSTLIAEEIGVTMDQIDYEFAPSNAELYANLFFGGFQGTGGSTAMANSFMQY
RQAGAAARTVILEAAAQAWGVEAGSLDIVDGMVTGGGQSAPLGDFVAAAAQLEAPAEPVL
KTPEQWRLIGNPQVRRLDSEIKGNGTAMYAMDVHLPNQMVVMLARPEQSGGLVASFDDSE
AKSIKGFIRAATLPNNAAVAVYAENTWAAMQSRDALSVEWDLSAAETRDSTQIKDEILAA
LEGDAEYNVTKTEAGPMDQAAQVVEKTFYFPLLAHAPMEPLTCTIEANEDGGVTLHDGAQ
MPTGPHMALAQILQLPMDKVRINTMLAGGSFGRRATPNADYQVEAALAFAITDRTRPVKL
VWSREDDVRGGMYRPAFGHKVKVGLSAEGEILAWEHRIAGQSIMKGTAFESMMVHDGIDH
SSVEGVSDTPYTLPGFRVGLTDTQKATSTLWWRSVGHTHTGYAMEAMMDLVAKAAGRDPV
EFRLAHLGDSADAKRKAAVLKLAAEKGNWGNAPAGRSQGIAVHKSFGSFVAEVVEISGNP
DDGVQIEKVTCAVDCGIAVNPDVVKAQIEGGVGYGIGHVMRDEITLTGGVVDQSNFPDYE
PLRIGDIGAIETHIIPSAEAPSGIGEPGTPPSAPALANAIANTGVIVANLPMINDGVEFA
>A0A840IMY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis jiangsuensis|TrEMBL
MPQHTFMLNGTRVTVEAEDEERLLWVLRDRLGVTGPKYGCGLDVCKACTSHINGKAFNPC
SVPVSKIEADDEVTTIEGLPATVGKDLHPMQEAWLDLDVAQCGYCQPGQIMAAVAKVRQA
RAAGHDVTDADLDEIRNICRCGTYARIREAIVVGAKNM
>A0A0A1I3N0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. SHC52|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVQGQNVSTIDALHADPVGQVVQKAWLDTAVAQCGYCQGGQIMSATALLKSNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A1X7BVF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius aestuarii|TrEMBL
MLGGVVFGAVMYKIPHRNPLQGDKQEGQAAITPYVLITPDGITLITPRADKGQGAYSVQA
ALIAEELDVRLDQINIDPGAPAPAYYNTALASDLLPFRSTNTNYLTELARSIADAPVKLL
GIQITGGSTTVPDGYEKLRWAGATARETLKAAAAQQTGLPVAQLTTRDAEVILPDGTAVS
YVSLASRAADIDPVKVDALRDPSEWRLIGKPMQRIDITAKSTGRQDYGIDVRLPGMLHAA
VRLNPRRGPVNDYKATQAETMRGVKAIIPVTDGISVIADNSWRAMQAAQAIKADWGPAPY
PAEMVEHWQALADSFAEDHLDSQFLDQGDVTATDTPIIAEYRAPYLAHAPLEPINATVLV
TDTRIDIWTGTQIPRFIQANISALSGFDPDDIHVHGQMIGGSFGHRLEDQVVRHATEIAM
QMRGTPIKLTYSREEDCAQDFTRQIAMARLRGGVRDGKVETCDLGIAMPSIIASQMSRQG
VPIAGPDAQIVAGAWDQPFDIPNYRVTGYRAPDLAPISSWRSVGASTNGFFHDCALDELI
HAAGADPLAERIRLCNHDPSRKVLEVVGEMSDWSAAMDEGQGRGVGFCLSFGVPCAVVIE
VTNTPRGIRLDKAFAAADVGRIIDPVNFEAQVSGGVIFGLGHAINCEITYADGMAEQANY
HQYEAMRLYQCPQVEIRGLENGERICGVGEPGVPPAAPALANAIFAATGQRIREMPFNKH
IDFV
>F4CWJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)|TrEMBL
MPVYGFTLNGNPVTVDAPEDLPLLWALRDKLGVTGPKYGCGINVCKACTSFLDGEDIRPC
SVKVSAAEGREVTTIEGLADGDKLHPVQEAWLEYDVAQCGYCQPGQIMAAVALLKRTSSP
TDEDIRAIENVCRCGTYFRIREAIMSAAEKMS
>A0A2N7R051|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dyella sp. AD56|TrEMBL
MSDANESKMPLSRRHFLKVLAGTAGALIVGIPFAEATDAPVPPSMLGDTLYGLGAYVRID
ADGNVVIGIRDPDTGTGTSTSLARIIADELDADWTRVSVVPLGLGVDDDNGKPRWVYGHQ
TSGLGDSIPAAWADLRGAGALARWLLMQAAARRLGVPADRLRCEEGSVVAPDGRRFGYGT
LVDAAAKIQPPDSPVQPKTPDHYTLIGQPAGDINARAIVTGQTAYALDTYVAEALVAVLS
HCPWPDGSVDSLDTTDTLAVKGVVKVVQIKPEAGVPLGQTVRSPAVAVLAENTWAALQGR
AKLKLHWKPGAQSENSAWFEQQAADVVNDKDAQPAARVRNDGDVDSAAKKAARRIEATYV
QPWLAHATPEPMNCVVKIDKDRAVLVVPTQAPQQAWAVVQRLTGLSPAQIDIRVPRVGGG
YGRRLDHDYVAEAVMLAKAVEKPVKLMWTRDEDLTQDYYRSATVHKFSAALDGKRQILTW
NQRMASASALAQRGVPDNRLWTSEVDAHQLPAGLVPNLRSDWYSLPSAMLRGPSRGTSHV
SNAFAVESFVDEIAHSLKEDPLVTRLRLIGEPRMIPLGDGRTLDTGRLINVLKLVADRIE
WKNWLRTVNGLGIACWHIDGAYVAHAVEASLQGDKLNIERVVCAVDVGRVVNPTGLEGQV
AGATLDALSTALNLSVSYKDSQVQQHNWKDYPLASMAQLPDTTDVILVPGDRAPTGASFL
GMPTAAPALANAVFRVSAVRVRRLPLLKEMLRML
>A0A177HCA9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium SB2|TrEMBL
MKITVDDKQHDVDVEADMPLLWVLRDELNIKGVKYGCGVAACGACTVHIDGVAVRSCQIS
VGDVDGAVKTINGLGTPYAMHAVQAAWAEHQVAQCGYCQSGQIMQAASLLSQNAEPTDAD
IDEAMSGNLCRCGTFPRIRAAVKTAAQTMKGA
>A0A377J8J1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia hollisae|TrEMBL
MRDFLNGYVPEEALLKNTTQSGTSRRNFIKLMSTAGAGLTLGVHLPSVAAGDKETAGTSF
VPNAFVRVGSDDTVTILIKHLDMGQGITTGLATIAADELDADWSKVTTEAAPANANQYNN
LLFGPVQGTGGSTAIANSFMQLRMAGAKAKAMLINAAAKVWEVSPSEIMTSSNTLSHNAS
GKSASYGEMAELAALQTVPSDEQVTLKTPEQFTIIGKTGTLRKDQGKSNGTATFTQDVQL
EGMLTAVVAHPPAFGAQVVSFNATAAKQSPGVVDVVQIPNGVAVIAKDFWSAKTGRDKLT
IEWARSAFNKSTEQLKKEYTALAQRPGQPARNEGDANKVLGASDDVIEATYYFPYLAHAP
MEPMNCVVLVGDGKAELWYGAQLQTIDQYAVAKVLGIKPENVTINTLFAGGSFGRRGNPH
SDYVVEATMIAKTKPGVPVKLVWTREDDMQAGYYRPMYVHKIRGAVDADGNLSAWEQRIV
GQSIAAGTAFEQFMVKDGVDSSSVEGASTLPYAIPNLAVELHTVQQPVPVVWWRSVGHTH
NAFSTETFFDELAHKAGKDPVELRRTLLKNHPRHLGVLNLAVEKSDWGKPLAKGKGRGVA
VHESFRTFVAQVVEVTVENGQITVDRVVCAVDCGVAINPDIIKTQMQGGIGFGLSPALVS
EITLQNGATVQSNFHDYQVLREMQMPEIEVHIVPSAEPPTGVGEPGTPPIAPAVANAVFA
ATGKRLYDLPMKMS
>A5EP18|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MTIIANPDSATSASRRGFERHLKVENVSRRAILQTLGLAGGFVLAAPLLSRPAFAAYETG
AGKMPHGTVVDPKIFVSIAPDGIVSILAHRSEMGTGVRTSLPLIVAEEMEADWTKVRVVQ
APGDEVKFGNQDTDGSRSTRHYLLPMRQIGAMARAMLEAAAAKRLGVPANEVKAVNHEVV
HSASGKRLGFGELAADAANQPVPAVDSVQLKSPKDFRYLGKGQVSVVDLHDITVGKARYG
ADVRLPGMKYAVIARPPVTGGKVKSFDSAEALKVPGVEQVLEVKGWPWPSKFQPLGGVAV
VARNTGAAIKGRDALKVEWDDGPNAAYDSVAYRAELEAAARQPGLVVRQEGDVEAALKSA
DKIVTGEYYLPHFAHASMEPPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLQLPPENVT
VNVTLLGGGFGRKSKCDFALEAALLSKTLGAPVKVQWTRDDDIQHDFLHTVSVERIEAGL
DKSGKVVAWRHRSVAPTILSTFAAGADHAAPFELGMGLVDMPFEIANIQCENPAAKAMTR
IGWFRSVSNIPRAFAVQSMVGELAHATGRDQKDMLLELIGTPRVVKLASVKDLWNYGEPY
ESYPIDTGRLRRVVEFVAEKGNWGRSLPKGHGLGIAAHRSFVSYIATIVEVSVDDKGKLL
VHQVDSAIDCGVFVNPERIQSQLEGAAIMGLSLAKYGEVSFKNGRVQQRNFDDHPVVRID
EAPLVTNVHIVPADADTPPSGVGEPGVPPFAPALANAIFAATGKRLRALPIGNQLAT
>A0A840NDD0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora gloriosae|TrEMBL
MGQHTFRLNGETVTVDIEDDVRLLWVLREVLGFYGPKYGCGINVCKACTSHINGKAFNPC
SVRVGDITPDDEVTTIEGLPGTVGQDLHPMQEAWLEEDVAQCGYCQPGQIMAAVAKVRQV
TEEGRDITDADLDEIRNICRCGTYTRIRKAIKSGAQNM
>A0A840RL46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Glaciimonas immobilis|TrEMBL
MSTFYDSELMQSTQNRHNDTEAAVANGLNDMSRRNWLKGVGAFTGLVLTVGAHGIVSAAD
APAPDKKYGGAKMPGGTVNNPLVFIAIGTDGIVTIVAHRSEMGQGIRTSLPMVVADELDA
DWSHVRVVQANADESRFGNQNTDGSRSMRHFFTPMRQVGATARLMLETAAASRWKVPVSE
VSAKNHEVHHTKSGRKLGYGALTVDAAALNVPTADQVRLKDDAQFRYIGKEKYGSVDFQN
IVTGNTQYGIDTRIDGMVYAVIARPPVFGGKVASFDAADALKVPGVIRVVELKGSPPPAL
FNPLGGIAVIANNTWAAIKGRDALKIKWDDGPNGNYDSTTFKVTLQEAARKPAKVMRDDG
DTMGALANASKKIEAEYYIPHLAHATMEPPAATARIVGGKCEIWACVQNPQATLETVAKS
LGVTREDVKVNVTLLGGGFGRKSKPDFAAEAALLSKAMDGKPVKLTWTREDDLRHDYLHT
VSLERLETTLDDKGMPLAWLHRSAAPTISSTFVVGAMGETAGELGMGAINIPFLIPNIRI
ESPQVPAHTRIGWFRSVYNIPHAFAVQSFVAELAAAAKRDHREYLLALIGPARKIAPKEM
SDTTNYGESPTLYPLDTGRMRNVVDVATKEAGWGRKVAAGHGLGLAVAYSFMSYVAAVIE
VVVNENGEISIPRVDVAIDCGPAITPDRIRSQVEGACIMGLSLAMTGEITFKNGAVVQGN
FHEYDVLRALSAPKDIRVHIVKHPFDMPLGGVGEPGTPPIAPALCNAIFAATGKRIRDLP
IRDQLKKA
>A0A1Y5S1L6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Palleronia marisminoris|TrEMBL
MPTLTVNGTTHEVDAEPDTPLLWVLREQLGLTGTKYGCGIAACGACTVQIEGQPARSCQI
QLQDIAEGEEITTIEGLSPDRSHPIQQAWIELDVPQCGYCQSGQIMAAAALLRDIPEPTD
EDIRSSMGNLCRCGTYNRIRAGIKRASELT
>Q1IQB7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Koribacter versatilis (strain Ellin345)|TrEMBL
MTSDALELELKQHDVNDKLHWFELDRRDFLRVFGGGMLICLSRVPGVAQESGRRGGGHEL
PKEVSAWLHIDADGKVTVNTGKIECGQNIRTSLAQQVAEELHVPVDSIAMIMGDTDLVPW
DAGTFGSRSTPTMGPQLRTMAAAASAALIDLAAQRWGLSGDFTLSTLDGKITNPRTKETL
TYGELTRGQQISRTVEGDPDLTPAIYWHVAGKPEIKVNGRDFVTGAHKYPSDIQRPGMMF
GKVLRPSAYKATLASVNTTAAEKISGVKVVRDGDFVGVVAPDAHTAEQGLKALTAKWNEP
QGPSNANIFEYLKTNLDGDPEAEGKPLDKVTANVNMARRYTLQYIAHAPLEPRAAVAEWN
GDKLTVWTGTQRPFGVKDELVEAFHISPSNVRVIQPDMGSGYGGKHTGDAAIEAARLARA
AGKPVRVVWTREEEFCWAYFRPAGAIEIRGSALNDGTLAYWEHHNYNSGPAAIGTPYESR
DKSIVFHPVKSPLRQGSYRGLAAPGNNFARESVMDELAHELKMDPLAFRLKNLKNERLIA
VSNAAAEKFGWANRRSTPELGQGFACGTDKGGYTAACAEVAIDPKTKKVKVRRVVQAWES
GAVINPNGLRNQIEGAIVQAIGWALFEAILFSNSKIENPHFAQYRLPRFSDAPKIEIVLL
DRKDLPSAGAGETGNNVLAPAIGNAIFAATGVRLRHLPMCPEREIPGVEAWPFKS
>A0A3G7U757|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MTETTLSREQWLAKAGVLLIVDDVLPPSGPVAKGGTPTVKPKELGLFIAVNDDGLVYAFN
GHVDLGTGVRTALAQIVAEELDLGMDQVRMVLGDTARAPNQGATIASATLQICAVPLRNA
AAEARRFLLARAAGRWGVSTASLKVEAGVIYAADGRTTTYSELVSDQHDQVRISGSAPLK
ALADYRLVGQDTARVDIPGKATGELTYVHDMRVPGMLHGRVVRPPYAGLDCGEFVGNSLL
SVDEASIAHIPGIVAVVVIRDFVGVVALREEQAIKAAAELQVQWKPWAHAAPDMRDVAQA
IRANPRVRRTVLDQGEVDAALANASQRMPRTYLWPYQMHASIGPSCAVADYQDSGSRVWS
GSQNPHLLRADLAWLLECDEALIEVIRMEAAGCYGRNCADDVCADALLLSRAVGKPVRVQ
LTREQEHLWEPKGTAQLMEVDGGLNADGSIAAYDFETSYPSNGAPTLALLLTGRVEPVAA
MFEMGDRTSIPPYDIDNMRVTINDMAPIVRASWMRGVSALPNTFAHESYIDELAFAAGVD
PVEYRLRYLKDPRAIDLVKSTAERAAWSPRTAPMQTASDDHLLRGRGFAYARYIHSKFPG
FGAAWAAWVADVAIDKHTGDVSVTRVVIGHDAGMMINPAGVEHQIHGNVIQSTSRVLKER
VTFEESTVASKEWGGYPILTFPEVPKIDVLMMPRQDQPPMGAGESASVPSAAAIANAIYD
ATGIRFRELPITPERVLAALNAGTLAEPAKSPQKRRKWWFGALFATLGALLATAWPFHSE
IAPIAPPSPGTWSKATLERGRLLAAVGDCAVCHTAPGGAPNAGGLAIQTPFGTLYSSNIT
PDVNTGIGAWSYPAFERAMLDGIGRDGRNLYPAFPYTAFRNINEADMQALYAYLMSQAPV
SQAPTPNAMKFAFSFRPLMAGWNALNLRRGEITPQPGRSEQWNRGNYLVNGLGHCAACHS
PRNLMGAEKGGEAFLAGGVVDGWEAPALTGLSKAPTPWTEDQLFTYLSTGYSDAHGVAAG
PMAPVVSELSKLPKADIRAMAVYLASLNHEAAAQAQVAAAPVPSPNGRRVFEGSCKACHA
DGLGPKLFGVSPSLATNTNVFSDQPDNLIKVILQGIPQPATRDLGYMPGFRDSLSNTQVA
DLVAYLRGRFAPNAPQWQGLEQKVAHLRANPGSH
>A0A7X0PKV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MMKRRHLLAGTGLAAITVVFSAGCALVPVIPKRPAPTPENAQGWIRHDGAGRYTLWVPCT
EMGQQISTALQALAAAELGVAPQAVQVRLPGTDDIARVRATVGSASVQDFALPLAQACAT
LREALASGTSTGGASLQAQPLPASALRSFQALASARAVAPAPGQLQALVTGQALFAGDTR
LPGMLYGRVLRAPVSAELDSRPGAMDDAAARADPACVAVVQSPLLQQMNSLGVGIVARSP
TALDRIEAALAVQWQVQGGFGPVEIAERIDIDRHLARGALRHTPRSDAMPEGEAWSIDLR
MDIPLAAHAPIEPRSATAVWSPKAQNGDPVLRVWAGTQDLFYVRDVLARHLALDAERIAV
QACRVGGGFGGRTLCTVELEAAVLAQAVGAPVKVHWSRAQEFAQGFQRPPSSHRVRARVH
QGHVTHWWHAFASSHILFTPAAMPPWMQTLADFAGDSGVARGSQLAYAVPQQRTEFTAQR
LPVHTGPWRGLGAGPNTLVVESAMDECARQAGADPLAWRLAHTTDPRLAAAFERVAREAR
WHDKRPASDATTLRGRGIAGGIYKGVSYAAAVADVAVDRASGQVRVTAVWCAHDCGLVLQ
PDGVRAQTEGNLVWCLGLVLHEELPVAASRVAAATFADYALPRMGDVPPLHVHLVESGAP
PTGAGETAMVAGAGAIANALRDATGHRFTRFPVRSEHVLQALTT
>A0A7Y7LVY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. SG517|TrEMBL
MKRSNESPRPPLGPDDGDTPGLRRREVLGYATAAPLVSATAGLAGLTASSRAVAALLPMT
PPDTTDLFDIGDAVTVTSLPTMPLVKVTNGENGRVRLALPRLEVGQGIATATAMMLADKL
RLPLSAIEVTSADASPELIWNQLTGGSSSVRSLHAGMPLLGGLGGVLSGSTPSVVGQRVT
RLDALDIVTGRKKFTLDQAVPGAMPTMVRRPPTINGKFVSINNMNTVMAMPGVIGVVPIP
STNGITPTPPGVAVMAETFGQAWAAVNALDVTWAAGPIAGESNATIMRKLKSALLPFALP
PLGALTVEGEFEFAPVSHCPMEVECAIADVRPDRAEIWAGLQSPIVTQQAVAAELGLPLN
KVTVHVVPSGGSFGRRLFWDPVLQAIQVSKALGRPCRLMYHRTDDMRHTRMRPPMFHKAR
ATMLLGQVIAFEQRVAGVRLDTRHGFGNMLEAAAIALPNAFPQTVGNFAIEQTMFKTMVS
SPYNFGVTTKLLTPVPIDMNTCSYRSVHIQPSRLVEEILVDEMARAAGKDPVAFRLEYLR
LPRARAVLKAVAEAAQWGKAMPAGFAQGVGVHQETKSFTACIVEIDARVPSAAKVVRATI
AIDVGTPINPSGIEAQLQGGLCESIALVLSAGLHIQNGLPLEGSYSQYHFSRMKNYPKDV
KIIIMPPSGEAIGGLGEVGLSASSGAIANAYARATGTRPRSFPLNFPVDFTPIPPGKLPT
PVNVQIPT
>A0A1U7D9G4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MVRLTVNGETRQIDASGDTPLLWVLRDDLSLTGAKYGCGAGLCGSCTVHLNGKAERSCQK
TLDDAADGEVTTIEGLHPEGNHPIQVAWRDLSVPQCGFCQSGQIMQAAALLKENPKPSDH
EILEAMAGNVCRCGCYQRIVEAVRLASAGI
>A0A2R8AX45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudoprimorskyibacter insulae|TrEMBL
MTTTLTINGTRHSVDLPDDLPLLWVLRDEIGLTGTKYGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGHGTPDALSALQQAWIDHQVAQCGYCQSGQIMQAAALLAQAPSPTD
AEIDEAMQGNLCRCGTYPRIRAAIHSAAKAMEG
>A0A3B0R5R8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MVKLNINGQVKQVDVDPATPILWVVRENLELTGTKFGCGIAMCGACTVHLDGKPIRSCST
PVSQAEGKTITTIEGIAEEDGTLNKVQQAWIEAQVPQCGYCQSGQIMSATALLKSNPAPS
DAQIDAAMADNVCRCGMYGRIRKAIKAAAGIEQPTEVEA
>A0A160VD07|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MDKEKFGRQGTGGSNSIRGSWDKMRKAGAIGKDMLMNAAAHNWSVPKKECYAEKGFIIHQ
PSGKKLSYGDLSMKAATLDIPTEVALKDPDNFRIIGKEIPRKDTPLKVNGTAQFAMDIDL
PNMVYAFIVRCPIFGGNLKSINDTRAREIEGVLDVFAVENGVAIVGTSTWAALRGRKALA
ITWNEGPNKDVDSKTIYEYLQKRGLKRGATGRKDGNAKRALNKADTVVEAVYELPFQAHA
TMEPMNCVVDVQSDLCRIWAPTQFPQQARKRASEITGLSIDNVEVNVTFLGGGFGRRAFN
DFIDDGLAVSKHMGKPVKLIWKREDDMRHDYYRPASRHVLKGGLTKSGKTTAWTHRVVAP
SIIFGQIFKYPIPFKDKLDIIALEGAKDLPYEIPNIHVDYKSANTAVPIGFWRSVYNSQN
AYANECFMDELAHASNMDPLQYRLQLLADAPRHDKILKLAAEKAGWGESTPTGRYKGLAC
HESFGSYVAQVAEVSIGEDNVVHVHRVVCAIDCGQTVNPSIVEAQMESSIVYGLSATLRG
EITIEKGAVVQSNFHEFEVLRMDEMPEIEVHNINSTAPPGGVGEPGLPPIAPAVANAVFA
ATGIRVRKLPIKPEDLHS
>A0A7W6D9B6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MVTVTINGTAHSVDAEPDMPLLWVIRDLVGLTGTKFGCGMAQCGACTVHVDGVPVRSCQT
FVGDIEGAQVTTIEGISGKVAETVQAVWADLDVPQCGYCQSGQIMSATDLLANNPKPTDD
DIDAAMSGNLCRCATYHRIRAGIHDAAKRLEA
>A0A841MH11|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MKNDLSKPSSINRREFLKSSGGIALFIGASGLFPVLVSCTDEKKLKEQFQKHPVSAWVQL
TENGDITIYNPAAEMGQGSMTSLPLIFAEEMDADWSKVQVEFSPQESEIYGSPGWSPDSK
LMFTVGSRTTNSYFSTMRKAGAQARYILLDSAAKHWNVPISELKTSNSVISHEGSGKKIS
YGELIPFLTTPESFPEFTEKEIKKVSDFNLIGKDVPRTEIPSKVNGSAQFAIDVRLPNMV
YGVLERGKRHGAKPTLLNDSEILEQPGIIKIVPFDYAIGLVAETLEQALLAKKALKIEWS
ESTSSGFNSDEIYSDYEKIAAQNEKGDVITEIGDVNDAWRNSSKTYSCDFKNDYVYHAQL
EPLNTVIQVSEDLQKAEVWVGSQQGADTKLGVPGILGVPSENVNVHLQYLGGGFGRRSLS
DFVEECAVLAKEMAPKPVKLIWTREDDLRYGTYRPMSLQRVKASLDSKGEINSFSHTVVG
DGGNLVASGIRNDHYAIPNQFANWLETKHGVRLKHWRSVGHGANKFAIESMLDQIAFDQK
IDPVALRRKLMSNSPRALATLEKAVEMSNWTEPSPEGRAKGISFVEHGSLGTGVCEISVD
RTTGKIKVHRFWIALDAGIIVQPDNVKAQMEGGIIMGMSSALQERISIVNGEVQQSNFND
YSLLRMEDCPDSIEISLIDSQEHPEGVGETSTPMVAGAISNAFLKLTGKSLTHIPFTPER
VLTILNS
>A0A7U7I8G4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas carbonaria|TrEMBL
MAHTLKINGTEYQVDVDDDTPLLWVLRDVLGMTGTKYGCGMALCGACTVHMNGSAVRSCV
MPVGSLAGAEITTIEAIGESPAGKRVQEAWLAHEVVQCGYCQSGQIMSATALLASNANPS
DSEIDGAMAGNICRCGTYVRIREAIKSASGQGPVARAEG
>A0A6J5KEJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia phenoliruptrix|TrEMBL
MKRRTFVIGGTGAVGALLVGWSVLPARQRLTTSAPLPVEGTQTALNGWVKIAADNTVTVV
VCKAEMGQGVHTGLAMLLAEELDADWSRVRVEEAPIDNIYNSVQNVVDDLPFRPDHDSIT
KRAVVWYTRKVVREAGTMMTGGSSSINDLWTPMREAGASARAMLIAAAAAQWHVPPGECV
AESGYVVHPSGHKASFGELSSMAAQQALPRKVTLKDSASFKLIGKPLRRVEAASKINGTA
RFGIDALPDGLLYASVVMCPTLGGTVASFDAAAAQGMRGFVKALAVAPYAGGTGGVAVIA
DNPFRAMNAVDAIKVNWTHGAAASLSSAEVERRLALALDDGDGHAYYRRGEVNDALNGAA
RTIAAEYHAPYLAHGAVEPLNCTVQVADGTANVWVSTQMPALARHHVANVLHLDDDKVQV
HTQLLGGAFGRRLELDYIAQAAAIAREAAGRPVQTLWSRAQDFTHDFYRPACVARLKAGF
DSNGNLVAWHSASASQAIVPDALARYYGAPRIPLDKTTVEGAFDQPYEWPAARVAHKIVD
LPVPVGFWRSVGHSHQAFFTESFTDELAAATEQDPIAFRAALLAQHPRHLAVLQRAAVLS
DWQHPLTHAADGAPRARGVALHEAFGSVVAQVAEVSIGPGSRIRVHRVICVIDCGLPVNP
NLIRQQMESGIVFGLSAALQDEITIVNGQVEQKNFVDFPVVRINDCPVIDVDIMPSQLHP
QGVGEPGVPPIAPAVANAVFALTGKRLRTLPLKLT
>A0A7W6AE77|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium brachythecii|TrEMBL
MIKLTVNGTERSFDGDPDMPLLWFLRDELGFTGVKFGCGQALCGACTIHLGGSATRACTT
PVSAAEGQEVLTIEGLSPDGNHPVQVAWRDLNVAQCGYCQCGQIMQAASLLKDTPKPSDQ
DIDDAMSGNICRCGTYPRIRAAIHQAAGQSASNQGGKL
>A0A1B7JNT8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Providencia heimbachae ATCC 35613|TrEMBL
MRLNINGKLIELKNISPETPLLYVLRNDLLLNGPKYGCGLGECGACSVLIDGEVVRSCST
PISMVGKRKVTTLEGLSESDELHPVQQGFVDEQAAQCGYCTNGMIMTLVALFKRNPNASE
DEIKKELAFNLCRCGTHVEILKAAQKAKMIIAQGGQV
>A0A7W7Q5Q3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinophytocola algeriensis|TrEMBL
MPQHTFTLNGTQVTVEVADDVRLLWVLRDILGVMGPKYGCGLNVCKSCTSHINGKAFNPC
AVPVSQIKESDEITTIEGLPATVGRELHPMQEAWLEEDVSQCGYCQPGQIMAAVALVRKV
REEGRAITDDDLDGLRNICRCGTYQRIRTAIKKGESRM
>A0A841J1V7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium subterraneum|TrEMBL
MRRIVDRVRDTGGAGVDRRSLLIGGGAVAGLLIAWGVWPRSYRPNLAVASDETLFNAFLK
IDTAGQIIVVVPQAEMGQGVSTVLPQILADELGADWRTVAVQSAPISPLYANSLLAGEAL
ASDWSALAGGAGRWAIAEFATRNAIMLTGGSTSVRMFTQAYREAGRAGRVLLCKAAAARW
DVPWETCDIVDGLVTDGQRKLRIGELAAEAAAFTLPDILPERQGEENRLWGEDVARIDLP
SKVDGSHNYAADIRLPDMLFASIRQGPVGAVALGAINEAAARKVTGFVQLVKRERWVAAL
GTDWWAANKALDALDPQFMVADTPLSSARIDAALDDAFESEQGRRLYEQGDLAAMFEGAQ
AVKREYSVAPALHLAIEPPCATARVEDGKAEVWTATQAPMFCRRAVAKALGFPESAVVLY
PLSAGGSFGRRMEHDTAVQAALLAQEVNRPVQLLWSRLEETIQDRPRAPAKARMAARLGR
GGRIEAWSAKVASPTALAETWARISDGADPMEAARTSAGSANRLAVSGMPGPYALSSFAV
DHYPAAIALPTGRWRANADGASAFFTESFIDELAHQAGIEPMSFRIQMLGGQARLAHCLT
TAAAMGGWQGGIAGSGQGIACHVMDGSFIAILVECSMDNGRPRVDSIVAVVDCGDQPHPD
IARQQIEGGLMFGLASALGGAAEYRGGLPRRAIMGRLGLPRLSDIGEISVELIQSSAEPG
GVGQIGVPPVAPALANALFTVTGRRHRNLPLVPVA
>A0A1E3H5A0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MLHHLNRPIAADPLLPATSRRGFLKAFGGVGAGLIIGLALPRTGTAEAATGAADADVVFN
PFVSIAPNGQVTVLIKHLDKGQGIATGLVTLVADELDASPDQMVAEFSPANTELYKNLFF
GIQGTGGSTSMANSFMQYRTAAAAARTMLVAAAAAAWSVPAGEIKVAGGRITHGERSASF
GDLAAAASALPVPAEPKLKTPEEWVYIGKDFRRVDVPVKSAGAPGVYGMDVHMDDMLVVT
VIRAPKWGATVKSFDAAEALKVKGVVDVKSGPFGVAVFADKTWPAIKARDLVTVEWDEAA
AETRGSEQIFAEYAELAKTAGAVANDGDAEGALAKAAEVIEAEYRFPYLAHAPMEPLNVT
ILADAGKSVTIWTGAQFQSVDQMVAGGILGIAPEKVAINTLWAGGSFGRRAVYNSEYIAE
AALVAKTWGKAQPLKLVWTREDDIKGGYYRPAYLHRVRAGVDAEGNISGWEHRVVGQSIF
TGTAMEQMVVKNGVDDTSVEGIHDTTYAIPGLRVELHSPKVGVPVLWWRSVGHTHTAYVM
ETMIDLLAAKAGKDPVAFRLALIKDDPRKAAVLKLAAEKAGWDTPPAEGRYRGVAVHKSF
NTYVAEVAEITYADGEVKVEKVVCAVDCGVAVNPDNIKAQMEGGIGFGLGAVLRNAVTLT
DGVVDQANFDTFEPLRMSDMPVVEVHVVPSAEAPTGVGEPGVPPIGPAVANAVFKATGKH
PRLLPFTTGDFA
>A0A1S7SIF0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Agrobacterium sp. NCPPB 925|TrEMBL
MVAVSLSVNGEIYRVDASPKTPLLYILRNDIGLNGPKYGCGLGECGACAVLVEGRAVRSC
TIPLGAVGTREVVTLEGLAHGDALHPVQQAFIDEAAAQCGYCLNGMIIAIVALLERNAQP
DEEAIRTALRHHLCRCGTHMEILAAARRAVACRKAQDECEPVQTTGPAQ
>A0A841J2G4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium subterraneum|TrEMBL
MKITVNGTAHLVDVEDDMPLLWVLRDELKIKGPKYGCGMALCRACTVHIDGEAVPSCSIP
VKQAENRNITTIEGLGTPVAHHIVQQAWIEQQVAQCGYCQSGQIMTAAAFLEKNPRPTDA
EIDEAMSPNLCRCGTYSRIRAAVKSAAAKMAER
>A0A518L6G7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Planctomycetes bacterium TBK1r|TrEMBL
MTSINVNGKVHDLGDVPDDTPLLWVLRDHLGLTGTKYGCGIAECGICTVHIDGDAIQSCI
TQLGEVGDSEITTIEGLSEDGSHPVQKAWKQHGVPQCGYCQVGQMMMAAAMLQSNNDPSD
DDIDSEMWNICRCGTYPRIRAAIKSAAKEMQAK
>A0A840VI68|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haloferula luteola|TrEMBL
MKTYELKINGGVHKAEVEEDTPMLWVLRDALGLMGTKFGCGVGQCGACTIHLNGQAVRSC
TLPVESVGNAEVTTIEGLAEEGELTPLQAAWCEHDVAQCGYCQAGQIMSAAALLKAHPHP
EDSQIDEAMAGNFCRCATYARIREAIHTAAAR
>A0A840V347|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haloferula luteola|TrEMBL
MNTLDRRSFFKVSALAGGGFFLVSGLRAETEPELRDFSPSAFIRLTPDGRVTIMAHKPEI
GQGVKTSLPMIVAEEMEVPWEMVTVEQAPINPAYGGQTAGGSTSVPSSYERLRKLGAVAK
TMLIAAAAEAWKVSPTECHAEAGEVVHGASGRKRSYGELALSAARQPVPAEDSVVLKDPK
DFKILGRRIGGVDNRAIVTGQPLFGLDQVQPGMLHACFLRCPVSGGKVKSANLAEVAALP
GVHKVFEVEGSGDRYGLYPGIAVVADSTWRAIKALRALKVEWDDGGHGEESSAAHAARAT
ELMKGAGAARLSERGQPEFSEGSLDVVYSYPHLAHNTLEPQNCTAVFRNGEFEFWAPTQN
GGSAIDAVARQFGVPKENVKIHLTRIGGGFGRRLMVDSMVECAAIARQIEGIPVKLTWTR
EQDLAQDYYRPGAWHRFRGAVDVEGKLSSWADHFVTFGLHSDQRPGNGAGIGGDEFPAHF
VPNFQLEQTVMPSNLPLGWWRAPGSCGLAFAIQGFLDEMAHAAGKDPLDFKLELLGDQEE
VHGYHVLRMKGALRAAAEKAGWGRSLPKGSGQGIAFHYSHRGYVAVVAEVTVSPDGKLSV
DRLIAGVDVGPVLNPSGAENQVHGSMLDGLSAAWFQQVKIEAGSVANASFAAYPVLRMPD
AARVESVFVNSPFSPTGLGEPALPPTAPAVCNAIFAATGKRVRDLPLQGQDLRWS
>A0A099L7A3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassotalea sp. ND16A|TrEMBL
MSKTINVNGIEYPIDVDEQMPLLWFLRDKLEFTGTKFGCGNGLCGACTVHVDGQATRSCI
TPVSTLANKNITTIEGLSEHGEHPLQKAWLENNVPQCGYCQAGQIMNAASLLATNSSPTD
DEIVSAMQGNICRCGTYQRIKKAIRVAADELAKEV
>A0A1Q8JXI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae707_Ps1|TrEMBL
MSHSHTQPLAERTIGRRRFLGYLLAAPTLVVAAEVGRQTLVDSAPTASAAAFPSPPQTPE
VYDLLDALRDEMRPFANLIRVEVNRDGTVSFALPRSDNGQGIITSTQMIIAEEMNLDPDQ
VIVTLADARPELMTNQVTGGSSTTFTTYTPIRVAAALAQGRLLNAAAAQLGQEQAVLTSR
RGLIIGNNGEELPFGSLTEAAASPVTEAVEVVLKPREEFTVIGTPHSKSDALAMVTGKKM
FATDLQIPDALPTVICRGPNLNSAPQGVSNIDEVRTMPGVTDVEQVSTGVAVRAKTFGQA
VDAVNALDVAWDGGTVEGENDNSVLRKLRAGELPLAVPQALGETVEGDFVFYFRSNSSLE
TNCAIADVRNGTAEIWGPAKNPIAAQAEMAKKLGMTQNAVTFHVVEGGGSFGRKLFFDAA
LEAAEVSQTMGKPVKLMWTRADDSRQGRVHPMATTRIRAQVTNKAVSSFELRHTSVATEI
NPGLGDGLTAAAFQAPLANLALSETIFELTQVTPYHFGASTRLLNEVDMRFNTSSMRNIY
SPDIATARELVVDQIAAKLGQDPYEFRSAFLKLDRWKSVLDRAAEEADWGKSMPAGTAQG
IGFHTEYKGATACVVELDCRPETVNRQIREARTGPRVTKVTFVIDIGLIINTRGLEAQMM
GGINDAIAMTLTSGLHLDDGHFLEASWDNYFYTRQWNTPPEMNIVLIEDSESPEPGGAGE
FGLAATCGAIACAYARATGTVPTEFPILHNEPLPFEPYPTVPPIPPSPTNGRELAR
>A0A0S4IEL9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MSAPDPVAELHRLQAGETVNLSRRRFLVGTAAGALVLGFGLPTGVARVQAAADAQRGTQV
PAFLEIRPNGTVRLLSPFMEGGQGPFTAMAQIVGEELDVDPAHFVVDSAPPGQAYVVMEN
GMRITGGSMSVRMSYPTMRRLGALARAMLLQAAAQQLGVEMSELTTTPGTVVHTTSGRTL
GYGELAKRAMDLPVPDPATVKLRDPAQFRWIGKPVRRLDAYDKSIGKALYCIDISVPGML
HAAVQHAPRLGMTVGQVRNEAQVSAMKGVHSVHRLPGAVAVVAPRWWHAKRAVEALQVEW
LEPAADSTVRAMPADFSSDGWLQHLADATGPARDEETAGDVASALDNAVTTVEASYHNQY
LNHAQLEPPSALARFNPDGTLEVWLPNQAPDMFRDDIAKRTGLPPDQITLHSPLLGGFFG
RHFLYESANPYPQAIALAKAVGQPVKLIWSREEEFLRDVLRPVAAVKFRAGLDAEGLPVV
LEAVSATEGPTEALAGKQGEKVDPTALEGLSGKAYAIANKRIAQVYVKGPAMLGYWRSVG
NSLNDFFYESFLDELADKGGQDPLALRQHLLRDNPRLTQLLQAVVELSGGWKHGPFTAED
GTRRARGLAMASPFGSEAAVIAEVSIEDGHVKVHDIWQAIDPGSIVNPAIIEHQVNGAVA
LGLSQTLVEEAVYVDGMPRARNYDLYPILPPARMARVHVRIVESGAKMGGIGEPPLPAVA
PAVANAVAQLTGQRVRSLPMSRHTFS
>A0A0H4W135|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella hinzii|TrEMBL
MTQLHINGQAKDVDVPGETPLLWTLRDELGMTGTKFGCGMALCGACTVHMDGAPIRACVT
PLSAAAGRAITTIEGVAADPVGQAVQQAWIAQNVAQCGYCQAGQIMTAVSLLKTTAQPTD
QDIEDAMSGNLCRCGTYPRIRAAIHQAAQILAQGGKQ
>A0A5E7HA38|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPMDFALSNLSRRGFLKGVGATSALVVAASWGWQDVFAEEVKKFGADGMPNGWVDDP
KVYVSIAGDGTVTVMCNRSEMGQGVRTSLTMVVADELEADWARVKVQQAPGDEVRFGNQD
TDGSRSMRHWYEPMRRCGAAARTMLEQAAANQWKVPVGECHAQLHKVIHKPSGRELEYGA
LAAAAGALAVPARDSLKLKQPSEFRYIGKEGTKAIDGDDIVNGRAVYGADVHFDGMLYAT
IARPAVYGGKVKTFDASAAMKVPGVVKVVQIESRPLPSEFQPLGGIAVVANNTWAAIKGR
EALKIEWDDGANASYDSIAYRKELEAASLKPGKVIRNTGNIDEAMSGADSTLEASYYLPH
LSQSPMEPMVAIARYKDGACEAWGPSQAPQVTRERIGERLGLPFDNVTFNVTLLGGGFGR
KSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWLH
RTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNIP
HGFAIQSFIDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRLR
TVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDCG
PQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKQVAVHLV
TPLGTVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQDWQKAPA
>A0A5E7TAI5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A6J5EGZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia solisilvae|TrEMBL
MSTTLILNGKSTTLDADPNMPLLWAIREVVGLHGTKFGCGMAQCGACTVHLEGQPIRSCM
MPLSAVAGRNITTIEGLHSKQAQAIQTAWVKHQVPQCGYCQSGQVMSATALLTQNPAPTD
ADIDAAMSGNICRCATYTRIRAAIHTAAESMQG
>A0A6J5DMW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia solisilvae|TrEMBL
MLFLNINGRETAVRSDPATPLLWVLRCELKLTGTKFGCGVAVCGACTLHIDGVAQTCCTK
PVGQLRGAKITTIEGLDGAQARALKAAWTRIDVVQCGYCQSAQLMAASALLTHNHKPGPA
DIDQAMTPVVCRCGTYPRIRQAIYEASGQKRS
>A0A0P1EP21|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria atlantica|TrEMBL
MALTLKLNGETHTVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLNGEPVRSCQ
TYIEDVEDAEITTIEAVGDDKIGAAIQQAWIELDVVQCGYCQSGQVMSAVGLLSENPKPS
VEEIDEYMHGNACRCATYQRIRAGIQRASEILEA
>A0A654C5A4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. T1|TrEMBL
MSGQASRRDILGGLLVAFALAPTAGLAQTGGGEGSGGPPTVAPDLPGTLAKFPDLDAWIR
IGGDGRVTVFTGKVELGTGVKTAMAQLAADELDVAIGRVDLITADTALTPNEGVTAGSQT
LEQSGTAIANAAACVRLLLAETAAARWGVAATTLFTRDGVVLDGQGRRATYAELAASTSL
AVRARADVPRKPVAARRLIGRPVPRVDLPAKLTGLPSYVQDMRLPDMVHARVLRGPSSGT
RLTPDLAALRRQPGVARVVEVGRFAAIVGPREWPLEQALRVANQSVWARDAAVPALPPMP
DGLLEMRRESTVIDTRRDAAAASGVRRLSARYDRPYLMHGAIGPSCAVALMAEGQLTVWT
HSQGVEPLRTAIAELVAMPADRVRCVHREGAGCYGHNGADDVAGDAALIARAMPGVPVRL
QWSREQEHGWEPLGPAMLAQIDATLDASGRIVDWRHQVWSNTHSTRPVAAGDLLAGVEVV
PPFAPTPPKPIPQPNGGGDRNAIPLYRFANQSIVSHFLPDMPVRVSALRGLGAHLNIFAL
ESAMDELAAAAGRDPVAFRLAHLDDPRAAKVIRRAAARFGWSRYRPRPNRGRGFAFARYK
NHGAYCAVALDVERIPDEGRLIVHRAVVAVDSGEAVNPDGIRNQVEGGVLQSLSWTAYEA
AGHDGTRRTDYDWSGYPILRFADVPHSVAVEVIDRPGTPFLGTGECAQGPTAAALANALA
AATGVRTRSMPLAGGLATRS
>A0A369QDP9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Adhaeribacter pallidiroseus|TrEMBL
MSTQVQNSRRNFLKISAAAGGGLFLGFNWFRTEAATTAVMDEAAIAAGNIEFNSYLKIAT
DGLITIYSPNPELGQNIKTSFPMIVAEELDADWAKVKVEQAKLDKKYERQLTGGSGAVPH
SWQRLRKAGATARQMLMEAAAKRWNVPVTELSTDKGVVWHKTSNRKLTYGELATEASQIP
VPAEVKLKDRKDFKLIGKPIKNVEHHSIVTGKPLFGLDFYREGMLFAMVQRPAFGMKLKA
VDSAAAKAMPGIVDVVTFKNSVAVVGKSTWQVKKAREALKIEYEKEGNIESTADHDRIMQ
ELLNKPEATERRKDGDVESAFKNAAKVIKSEYQCPFLSHSPMEPMNFFAHVRPDGVELVG
PTQTPDLARNETAKLLNIPPEKVTVEITRLGGGFGRRLKADYVLEAVEVSNLVKAPVKVI
WTREDDMTGGSYRPAVRYRFEAALDAQNNLIGYKLRGASINAGNSTREHNFPSGAVDNLL
IDSVEHQSPITTGPWRAPITNFLAFAEQSFMDEVAQAAGKDPVQFRLDLLDKAKAKPVGE
IKYDIDRMKGVIQLAAEKAQWGKKKGVFQGFSVYFSHASYVAQVGEVVVQKGKPVLKKIY
AAADCGIVVNLSGARQQMMGGIVDGIGHAMYGNLTFKDGLPTQKNFDTYRLIRLKEIPEI
DVNFVDNGIDPTGLGEPALPPTGGAVANALFKATGKRLKNQPFAEQQELKDVI
>A0A369QDG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Adhaeribacter pallidiroseus|TrEMBL
MEPREAEDRLYPAELPELLPAAPEVINRRKFIKWLGGGLAVALVMPPAALAASPKETAFT
NAKLPESQIGAWLHISPDSMVSVFTGKVEVGQNIRTSLAQVVAEELRVPITAINMIMGDT
DQVPYDAGTFGSRSTPAMGSQLRKAAVSARETLLTLAAQEWKVDKSTLQAANGKITHPAS
RQKISYGDVVKGKQLVQEIIPDLPATPVPEWKIAGTSVPKVNGRRFITGKHTYVSDMKLP
GMLYGKILRPPSFGATLITVDVSKAQAINGVTVVHEKDFVGVAAPDLTAANKALAAIKAE
WQTKPQPARAEIFDFLKKNASNAPEGGRNAGTSKGNITQGLSSADKTLKATYTVEYIAHA
PMEPRAALAQWKKGKLTVWTGTQRPFGVQSDLAEEFNLPKEQVRVIMPDTGSAYGGKHSG
EAASEAARLAKAAQKPVKLTWTRPEEFTWAYFRPAGVIEVSSGIKNDGTLTAWEFHNYNS
GNSGIHTPYTVENQQIQFHPVESPLQQGSYRGLASTANIFALESQMNDLAQLANLDPLAF
RLKNLKEPRLQAVLEAAAEAFGWGKAKPAPDHGFGLAGGTEKGGFTASCAEVVVDRTTGA
VKVLRLVTAFECGAIINPAHLDQQIMGAMVQGLGGALFEAIDFENGKILNPTFAQYRVPR
FKDVPAIQIVQINRPDLPSAGAGEAPIVGIAPAIRNAIADATGIKLKTLPLAPNGLSAHL
KKS
>A0A447TAN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chromobacterium violaceum|TrEMBL
MAKRHGQGAPIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGT
PFAPMMIKNGIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESY
IDELARLARQDPVAYRLALLGKAPREQGVLREAARMAGWAASCPRATAWARRCTAPSAPM
SPRWWRCRSRARS
>A0A484V1W7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRVGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPET
PAGWRALAFNGHVDLGTGIRTSLAQIVAEELEVPFERLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAAHWQVSAAALRARAGRIVFADGADPRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGALTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREV
PPAPDLSDLEAALRANRAEPRHLRGDGNAAHALATTPAARRLRRSYVWPYQMHASIGPSC
AVADHADGHLTVWSGTQNPHMLRVDLNRLLELGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLVDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGSVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGTPGGDGLLRG
RGVAYARYIHSKFPGFGAAWAAWVVDLRVDPASGHITLDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPDIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRKALLARKQPGMPRADAPLSDTQPA
>A0A7T6X7D0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia pickettii|TrEMBL
MELDVNHKPVSVDCDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VAAVAGKHITTIEGLAGGEGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLAQHPDPTD
ADIDAAMTNICRCGTYPRMCAAIKRAARALREGRA
>A0A1Y5RH95|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudooctadecabacter jejudonensis|TrEMBL
MGRVKTIARRSFLIGSAAILGGVAFGVYLYKRPVENPLLADLAEGEASLTEYVRITPEGV
TLITPRADKGQGAYHVQAALIAEELDIDLDQVTVDPGPPSAAYYNTALSGEAPGFMVTDD
SFGANAMRTVMDAAMKIMGVQITGGSTTVADGWDKLRVAGAVARETLKAAAAAQTGVSVA
DMTTDRGAVVLPDGARLEYTALAEAAADIDPVTEVTLKEPGDWRYIGKDMMRLDVLAKST
GTQSYGIDFEMDGMVHATVVTNPRKGGEMLSFDASEADAMRGVQAVVPITNGVGVIADNT
WRAFEAARMVSFDWGPAPYPAEQADHWAALEAAFNDDQLDSQYRDEGDVEAALAGGATVE
AEYRAPYLAHAPLEPINATALITDTRADIWTGTQVPRFAQEAVAEITGLPVEDVHIHVLM
MGGSFGHRLELDVVKQAAEVGMAIKGTPVKLTYSREEDTAHDYLRQIAMARVKGTVSGGQ
VQSLDLGISMPSVISSQMGRLGQSVPGPDASIVQGAWDQPYGVPNYRVSGYRAEPLAPIS
SWRSVGASSNGFFHESALDELIHAAGADPMEERLRLMWDDNSRATLEAVAEMSGWDGPQM
GQGRGRGVAFCLSFGVPCAEVVEVTNTDRGIRIDKVYAAANVGRIVDPINFEHHVSGAVI
WALGHAISAEITHSDGMTDQLNYDGFEAMRNYQAPQIEVRGLELGDAVRGIGEPPVPPAA
AALANAIFAATGQRIREMPMRNHIGFV
>W6W080|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. (strain CF080)|TrEMBL
MTISITVNGAKHEIGSDPDTPLLYVLRDDLELNGAKFGCGLGQCGACTVHIDGKAVFSCI
TPVGAIGDRSIRTLEGLGSVDAPGIVQKAFQDEQAAQCGYCIAGMIMRAQALLEKIPDPT
DEQIREHMQPNLCRCGTHARILHAVRRASDVMAGVVR
>A0A2N7R7F1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. AD21|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACIT
PATAVANGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A7W9KMN3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kutzneria kofuensis|TrEMBL
MAEDLRRRRFLAYLLAAPTLAVAVQWIDPQRADAAVPTLPQPEEIFDLGDLQNLAAAPTA
NLVAVQMNRDGTASFAVPRAEVGQGITTAVAMMVAEEMDLPLDKVVVTLADARPELLMNQ
LTGGSNSVRSIYTPVRTAAAIARQRLVQTAAAQWGTTASSLTTRDGVISDSTGRTATYAS
LAVAAASSKIEAATVQLKSTSDFKVLGTPRNRVDARDIVMGRKTFGMDIQVPNAKPTMVR
RPPTINGTVRSVNNQAAVLAMPGVTDVAVVSHGVAVRADTFGQCIDGLRALDVTWGPGTV
DGESDASVLAKLKAAQLPMLVPGLLTEVLDAEFTFAFASNSPLEPDNAIADVRKDSAEIW
SSLKVPIVAQEDIAAQLGLPVDAVKVHVAQGGGSFGRHLFHDVAAEAAEISQKMGKPVKL
MWSRTDDFRQGRTHPMCTSRVRVTYALGNVVSYEQRHTSVQTEFSHGLGEMLTSYAAKLP
IAGNLSFAESIFLLTQSSPYNFGVTTQLLNEIPLKFNTGSMRNIYSPNVVTAQELVVDRL
AAKMGKDPVSFRRSFLRDAKLKAVFEKAVSVGQWGRALPAGVAQGIAVHSEYQGAVCCLV
EIDCRPETVNRPVTDGVTGPRVTKALIVVDPGFAINPRGLEAQMIGGMNDGIALALTSSL
HIKDGIPLEGSWDNYFYTRQWNTPLDMKVVIAPSGGDPSGAGELAVAPAMAAVACAYARA
TGTMPTYFPINHGTLGFEPYPTEPSTPQSPTNGLDS
>A0A1A0D6Q3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus|TrEMBL
MSTHSPSSTTRLKTSRRRVLQAGGALLLATLWPTARGRAAQASQAGTGVLVEDVATPFAP
NAFIRIAADNTITLILPNIEMGQGIYTSSVMLMAEELGIDPFAVQIEAAPPGGGAEITGG
STSIMTEWLPLRQAGAAARTMLVQAAASHWGVAPESCTTANGAVVHTPTGRTVPFGDVAE
AAAKLPVPKEPKLKDAANYTLIGRKHHRLDSQIKVDGTARFGMDVQVPGMKIGTVAACPV
QGGTVRSMNRNAALAINGVHAVLVTDNKDTVCVVAEHYWAARKGLKALHIQWDFGKNAAI
TTQTIYDDLHAGLNGPAIVANAKADAPGVIGKSGTTYTATYQQPLLAHSPMEPINCTAHV
RPDGCDVWAGTQVAERARDTAAEITDLPASKITVHSQYIGGGFGRRLEHEYVTQCVQFAK
QVPYPLKIIWSREEDITKDRYRPAYVDKLTAALDDKGYITALQHRIVGPAVVARWDPPEL
TKDGYDEDLSLATVVTPYTYPAYRLEFARREAPGITTAWWRGVGGTRGLFVVEGFIDELA
ARAGADPVAYRRAMVQNNPRALAVLERVAADAGWGTPVPKGRARGVALQFAFGSYMASIA
EIEMPSPDEVIIHRVTAAVDCGQVINPDQVIAQIEGGLIFGFSAALYNEITLENGRVQQQ
NFNTWRVMRMNEAPRRIDVVVMPSKEDPGGIGEVGTAAAAPLLANAMAAAQGRRYRSLPL
LSARNTEGKE
>H0T4I0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MSLSKRFGLALLTLLVILGAAALAATWRPAIAAIDPPGFQAFEPALVKRGRQLAAIGNCA
DCHTVKGGKDFAGGLPVATPFGTIYSTNITPDPETGIGRWSEAAFERAMVSGVDRDGHHL
YPTFPYDHFTHVSADDDRALYAYLMTREPAHAAPADNHLAFPFNLRPVIAGWKLLFLHRG
EVKPDPEKSPAWNRGQYLVEGLAHCGACHTPRNAFGAERKAASFSGGEADNWQAYALNAQ
SPAPVPWTEDALFEYLRQGWQRDHGVARGPMAQVINNLASIDADDIRAITTYTAAMFAPR
PDRGSGGETAVADAAARQAKQPAGPPQAATSTAEGAALSADGQDGAAIYAAACANCHESA
RPLPYGGIDLHRSTGISAPDARNVANTVLYGLPARDGERSPIMPGFAASLTDAQASALLG
FLRARFSTRPPWSNLAQTIAGARQAQASFLRTAAEPPNISIPSPPRGQP
>A0A5P9GPG1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Erythrobacter sp. THAF29|TrEMBL
MELTRRKLIAGAAAGGGLILAWYLMPRTYPNPLVPSRGEHVFDAWLKIAEDGVVTVAVPQ
LEMGQGVTTLLPQIVAHELGADWRQIAIEPAPISGAYANIPLAAKWMPLWDPLGRGLSEA
TDELLTERFARAQRFTATADGTSLLAFEEPCRTAGAAARAMLAQEAAERWDVPWEQCEVE
AGIVSYGNERATFGELAAGAATRTPLDPPPLRPEPPIAEALPDITDAPPLYPRIDLPSKV
DGSYQFASDVRLPGMVYASIRHGPNHGAELTGFDESAAQGIDGVVGAVRSRRWLAVAADT
WWTADKAIEAMKPQFKVAYPVGSEEMNARLDTSVDGGAGFRIAETGFGEDVMTRVDIARR
YEIEPAFAAPLETASAVARFRNGRLELWIASQAPEQARAAAAKAVGLAVEDVALYPMPAG
GSFDARLEHDHAIEVAAIAQELGRPVQLTWPRRDELIHSRPRTPAYVLIGAQLAEGGTST
LDAMRMRIACPPAMHEFGERLFDNTTPAAAIRDSSGRKDELACEGAVPAYRLPSLVVEHV
PVEIGLPVGRVRGNSHSYTAFAIESFIDEIAAANGLEPLSFRMPMLGDDVRLAACLQRAA
SLANWGGGRDQSGQGLACYRIGDAPTGGRIACVATARQGEGGMRVSKLSAAVDIGRIVNP
DLARQQIEGGLIFGIGIALGNAVRFRSGLPESYDYASLGVPGLADCPEIEIEFIASSAAP
ADPGELGAVIAPPAIANALFSATGLRLRRLPLLSGGI
>A0A7W7AB20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium taihuense|TrEMBL
MSISLTVNGRKRIVETDADKPLLWVLREDLDMPGTKFGCGAGLCGACTVHLDGDAVRSCQ
TPIADAAGKAITTIEGVGLNDIGKRVQEAWVALDVPQCDYCQAGQIMSATALLKQNPKPT
PEDIDGWMSGNICRCATYMRIRAAIRTAAGLPAEESVA
>S9QPX2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Litoreibacter arenae DSM 19593|TrEMBL
MGKARTIARRSFLVGSVALAGGVAFGTYVVHKPHDNPLAEQASEGEATFNPWVLVSSDAV
TLIVPHADTGQGVASMQAALIAEELDIEFGQFETSFGVPSAAYYNTAMASEAVPFMPTDK
GFAAETMRSAMGAAIKVLGAQVTGGSSSTPDSYEKLRAAGASARETLKLAASQRTGVPVE
QLKTAGGAVQLPDGTELKYTELAADAATLDPVTDVPLRDPSTWRMVGRNMQRLDVVAKST
GTMTYGIDLYLDGMVNGTVRMNPRKGAALNSYDASAAEAMKGVRKVVPITNGVAVLADNT
WTAFQAADAIEYDWAAAPYPAEQDGHWAEVAASFTEERLDSEWRNEGDVDAVMEGAETLE
LEYRAPYVAHQPLEPLSAVAKVTDDRVDVWATHQMPRFAVDKIAAITGHKTAQIHFHSQY
GGGSFGHRLEFLNITATVEAANQMRGTPVKITFSREEDFAQDFTRQIGMSRSKGAVKDGK
VVAHDLQIATVSSSRSQMGRLGQSVPGADSQIVAGAWEQPYAIPNFRVRGYAVPELAPTS
SWRAVGASSGGFFSDCALDELIHAAGADPLEERLRLMNHDVSRKVLEAVGEMSGWGSDLG
PNRGRGVAFVLSFGVPVAEVVEVTNTDSGIKIDKVWVAADVGRVIDPINFDNLMKGGVIW
GLGHAMNSEITYSDGMAEQSNFYTHEGMRLAQCPEIFVKGLENGSAVKGIGEPPVPPAAP
ALANAIFAATGQRIREMPFNKHIDFV
>A0A7W5PZ47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK313|TrEMBL
MIQLNVNGHNVEVDVPGDMPLLWVLRDTLGMTGTKFGCGIAQCGACTVHIDGRAMRSCVL
PISAVSNRNVTTIEKIGETDAGHRVQTAWLKEEVVQCGYCQSGQIMSAAALLAHVPNPTD
PEIDAAMAGNICRCGTYERIRRAIKEAASA
>A0A375ENS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTRFQVNGQPKDVDVPGEMPLLWALRDELGMTGTKFGCGMALCGACTVHVDGTAIRACVT
PVSAVAGRSVATIEGMEGDRVGQAVQQAWIQHNVAQCGYCQAGQIMTAVSLLKTTPAPTD
RQIDEAMSGNICRCGTYPRIHAAIRQAASRLAQGGK
>A0A120G929|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNTTEIIPGVTLGEPINLSRRRFLASTAVGALVIGFGLPLGTSRVQAATGAAAERGTQVP
AFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAYVVMENG
MRITGGSMSVRMSYPTMRRLGALARAMLMQAGADQLRVPLSELTTQPGRVVHAASGRSLG
YGELAGAALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYTIDLKIDGMLH
AAVQHAPRLGMTVGSLRNQAQVQAMKGVHSVHTLPGAVAVVAERWWHAKRAVEAIQVEWL
EAAADSTVRAMPADFSSDKYRDFLAAQQGPARDDENEGDVAGALASAKTRVEATYHNQYL
NHAQLEPPSALARFNPDGTLEVWLPNQAPDMFRADIAKRTGLSIEQVTLHSPLLGGFFGR
HFLYDSANPYPQAIALAKAVGRPIKLIWSREEEFVRDVLRPVAVVKFRAALDDKGLPVAI
EAVSATEGPTEAIAGKQGDAIDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGN
SLNDFFYEAFLDELADKGGHDPYELRLHLLRDNPRLTTLLQAAAELSGGWKRGPYTAEDG
TRRARGVAMASPFGSHAAVVAEVSIENGQVKVHHIWEAIDPGSIVNPAIVQAQVNGAVAL
GLSQTLLEEAVYVDGKPRARNYDLYPVLPPSRMAQVHVKIVESGEKMGGIGEPPLPAVAP
AVANAVAQLTGQRIRSLPLSRYTFS
>A0A1Y1J136|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Comamonas testosteroni|TrEMBL
MKFTLNGQEVDAQSATADTPLLYVLRNDMQLNGPKFGCGLGECGACAVLIDGKVARSCSV
PLKAVDGKKVTTLEGLSPDASKAANAQALQDRAVLDVSAAETKAPATARTYTLHVVQQAF
VDAQAAQCGYCTNGMIMALVALFNQQPKASDEEIRHALSGHLCRCGTHVEIMQAAARARE
LIAKGHSPALPAAGASTTAKAA
>A0A0D5VLG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fungorum|TrEMBL
MTTFNINGQTHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDKKITTIEAVGDTPAGQKIQQAWRQLDVVQCGYCQSGQVMSAASLIASNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGA
>A0A5S9NUV7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania aliphaticivorans|TrEMBL
MSLSRRSFIKSTALLGGGLAIGFNLSACSKSQPYPNMNATALQPNAFLQVTASGDVVLQL
HKVEMGQGVYTGLTTLAAEELKMDPALIKVEHAEFHPDFRDPEFYVMITGGSSSARLSYQ
PLREAAATVAALLKAAAAQQLDVSESTLSLRDGRIVHVNGDISFADVIATARTLPAPAAV
TLTSPQDFQYIGRVNQRLDAIDKVTGNSQFGIDVTYPEALTAVMLRSPSFGGKATSFDAV
AALAKPGVKSVINVDGAIAVIAQTYWQAKQAASAVTVTWGKGPLAGVSSESLRAERHTLI
ETKSGKNVEEEGEQSAAVGELIEALYDVPYLAHATMEPMNAVAVVTDESIEIWTGNQSPD
IALSAIADATGHRREQIRIHNQMLGGGFGRRIMPDYLIEAARIAQLSGYPIKLVWSREDD
MRGDYYRPNSSVKMSATIDGNTVTSLQAKVAAPSIMGQFVGAVTNTLLPQWLPNALHPQI
GNLAASSDPAATEGLVHTDYDFPYKRTDYVMQETSVPIGYWRSVGHSQNGFFMESFIDEL
AARTKQDPLQFRLDHLPADSSRRRVLEELRVKADWGNPVKGQFQGLAVHESFQTMVGQCV
SVSIEANKINVHSVVCVVDCGLAINPDIVTAQMEGGIVFALTAALKGDITIMDGAVQQSN
FHDYELLRMNESPDIVVHIMENASSPTGVGEPGVPPLAPALANAVFAATGQRLRQLPLKL
V
>A0A2N7WJB7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia rhynchosiae|TrEMBL
MSQGLLDAHNGAKASKAEANEPRGFSRRTFLKLGVTVGAAAGGGLLLGFSMPAVSQDQKA
GKSVIGGDANETPQDGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVS
LDTVTLDHAPPDEKLFTDPLLGGQLTGGSTSIRYAWEPMRKAGATARTLLISAAAQQWQV
DAASCHAQAGQVIHAASNRSIGYGQLVDAAAKLPAPQNVPLKDPKDFKIIGTAVKRLDSP
EKVDGTAIFGLDVRVPDMVYAAIANCPVFGGTLASVDETNAKKIPGVRQIVKIDNAVAVI
GDHTWAAKRGLQALDIKWNEGAGAKLSMKQIVDDLAQASQRNGAVARKDGDVARGFSNAK
TRVDAVYQQPFLAHATMEPINCTVHVRPDGCEIWIGSQVPTRVRDAAIAVTGLPADKIVV
HNHLIGGGFGRRLEFDMVTQAVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLD
ANGKPLAWQHRIVGSSILARFAPPAFKNGLDPDAVEVASDLPYDLPNQWVDYVRQEPHAI
PTAFWRGVGPTRSTFVVESFIDELAAEAKVDPVKYRRDLLGKTPRALNVLNTAAQAANWG
SAVPKGQGRGVSVMHAFGSYFAIVVDVAVDQGEVAVKHVVCAVDCGMAVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIDVHIVKSSEAPGGIGEPGTA
ALAPALTNAIFAATGRRLRQLPVGSQLQTA
>A0A484QJM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MAPAAPLLFVLRNDLALNGPKYGCGLGECGACTVLVDGVAARACVMPVRGVIGREVTTLE
GLGDVACPGPTQQAFIECQAAQCGYCLNGMIMMIEALLRRQPAPDEARIRQELRHNLCRC
GTHVEILQAARRAVALHAQARETACAKRSGQ
>A0A484QLB9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPGT
PAGWRALAFNGHVDLGTGIRTALAQIVAEELDVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAARWQVPATALRARAGRIVFADEADTRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGVLTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVTHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKAHWREI
PPAPDLGDLEAALRANRAEPRHLRDDGNTAHALATTPDTRRLRRSYVWPYQMHASIGPSC
AVADHANGRLTVWSGTQNPHMLRVDLDRLLDLGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLIDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGRVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGAAGSRGAPGSDGVLHG
RGVAYARYVHSKFPGFGAAWAAWVVDLRVDPASGHVTIDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPEIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRNALLARKQPGMPRADAPLSDTQPA
>A0A105HXT2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cepacia|TrEMBL
MVTLNINGETRTVDAPDDMPLLWVLRDVVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRKITTIEAVGATPAGHKVQQAWRELDVVQCGYCQSGQVMAATALIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAVKQAAKEA
>A0A379Z9T0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella algae|TrEMBL
MSQLKINGRLFSVEADPNMPLLWALRDLLGLTGTKFGCGAGLCGACTIHLDGKPARACLT
SLKSAEGKNITTIEGLDNPALKAAWSKHKVPQCGYCQTGQLMSAAALLSETPNPSDQQID
DAMSGNICRCGTYTRIRSAIKDVAVKGGQSS
>A0A0K1ZQL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MVTLTINGRPVEVDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAVVGAQITTSEHIADDKIGKAVLAAWIKHDVAQCGYCQSGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAARSLA
>A0A291FLU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter piscinae|TrEMBL
MASLKKFTRRSFLIGSAAIVGGVAFGTYKYHQPAPNPLAQVDGRAVLNPFVFVDQSGVTL
IAPRAEMGQGVKSAWASLIAEELDVDPAKVTVLHGPAAKAYYNSAMMSEALPGRGYDASD
FQHSLGEIVGHMSKFLDLQVTGGSSSMRDGFERMRHAGASARETLKQAAADQLGLSRDQL
TTEDGHVIAPDGARLPYSALANAAASLAPIEADLRPASEWRLIGKDVPRIDMVAKSTGTA
EFGVDVRLPGMKFAAIRQSPHFGVGKTAFDASAAEGMAGVERILDLGDAVAVVASNTWLA
QQAVDAIDVTWEKAPYPETTEAIFDEISRSFDAAPNSTMRDDGDVDALPKGATVIEAEYR
LPYLAHATMEPMNATALYSGDSLQIWAPNQGPTIVQKNAAALAGLDTDAVEVNTTYLGGG
FGRRIETDYTDRAVQIALQMPDTPVQLTWSREEDMTHDVYRPGAVARYRAAVKDGKAVMV
HGKIAAQSATVEGAGRMLGLPMSGPDKGHVDAAFNQPLAIPNFRVEGYLAAPMLPVGFWR
SVGASFNGFFSDSIIDEMAHAAGRDPLDFRLELARAEWDPAAKVLETVRDMSGWTGQTPD
GIGRGVAMAYSFGTPVAQVIEVADEEGQIRMTNAWIAADLGRVIDPKNTRAQMFGGMVYG
LSAACFGEITIDGGAVEQENFPDYDALRMHTMPRVEVTLLENQPRMGGAGEPGTPPAAPA
LANALFDLTGKRARQLPLMHEFDLLV
>A0A031GQ33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MRIEWLNQEALQHGGVTLGAALASAPVAVVGAADGVSRRGFMKAGAVAGGGLMLGFFLPG
AGKLAQAADAAPAKPVYAPNAFLHIAPDNTVTVQVNRLEFGQGVQTSLPMLIAEELDADW
SLVHGALAPAGEQYKDAAYGMQMTGGSGSIAHSFTQYREIGAKARAMLVGAAAAQWKVNP
DQVRVAKGVLYGPGGQKATYGEFADAAMRQPVPTTVKLKDPREFSIIGKPVKRLDAAAKS
TGKQQFGIDFKPPGAKVAMVARPPVFGAKVAKFDASKAKAIKGVLEVLEVKTDRGGSGVA
VIADGYWPAKQGRDALAIEWDTSAVEKVSSDKQLAAFKALAKTPGTIARPADMGKLAKAP
KKIEAVYEFPYLAHAPMEPLNCVVDLQADKCTMWVGSQFQTGDQAAIAATSGLKPEQVTL
HTMMAGGGFGRRAVPSSDYVVEAVNVAKAYRAAGKSGPLKLMWSREDDIKGGYYRPSHVH
RAQIGLDAKGKILAWDHTIVGQSIMAGTPFEAFMVKNGVDGTMVEGMGEPYTLPMKLSVH
TAKANVPVLWWRSVGSTHTAFVMETLIDEAAHVAKMDPVAYRKQLIDAKHTRHIAALDLA
VAKSGYGKKKLPKGQAWGVAMHESFNSVVAYVVTASVVEGAPKLHQVWAGVHCNLAVNPL
TIEAQVQGAALMALGMTIPGAAITLKDGVVEQQNFGDYPVPRMPDMPVIEVHLVPSGDAP
TGMGEPGVPPLAPAFANALFALTGKRLRKLPFDLAAA
>A0A377RKC7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MRIEWLNQEALQYGGVTLGAAMASAPVAVVGAADGVSRRGFMKAGAVAGGGLMLGFFLPG
AGKLAQAADAAPAKPVYAPNAFLHIAPDNTVTVQVNRLEFGQGVQTSLPMLIAEELDADW
SLVHGALAPAGEQYKDAAYGMQMTGGSGSIAHSFTQYREIGAKARAMLVGAAAAQWKVNP
DQVRAAKGVLYGPGGQKATYGEFADAAMRQPVPTTVKLKDPREFTIIGKPVKRLDASAKS
TGKQQFGIDFKPPGAKVAMVARPPVFGAKVAKFDASKAKAIKGVLEVLEVKTDRGGSGVA
VIADGYWPAKQGRDALVIEWDTSAVEKVSSDKQLAAFKALAKTPGTVARPADMGKLAKAP
KKIEAVYEFPYLAHAPMEPLNCVVDLQADKCTMWVGSQFQTGDQAAIAATSGLKPEQVTL
HTMMAGGGFGRRAVPSSDYVVEAVNVAKAYRAAGKSGPLKLMWSREDDIKGGYYRPSHVH
RAQIGLDAKGKILAWDHTIVGQSIMAGTPFEAFMVKNGVDGTMVEGMGEPYTLPMKLSVH
TAKANVPVLWWRSVGSTHTAFVMETLIDEAAHVAKMDPVAYRKQLIDAKHTRHIAALDLA
VAKSGYGKKKLPKGQAWGVAMHESFNSVVAYVVTASVVEGAPKLHQVWAGVHCNLAVNPL
TIEAQVQGAALMALGMTIPGAAITLKDGVVEQQNFGDYPVPRMPDMPVIEVHLVPSGDAP
TGMGEPGVPPLAPAFANALFALTGKRLRKLPFDLAAA
>A0A8F7WP22|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylovirgula sp. HY1|TrEMBL
MTLFTCWNAVGVATLPTPKTENSGIFKSEDIKMIRFTLNGKPQELDSTPEKPLLWVLRDE
LELTGTKFGCGAALCGACTVHIDGQPARACITQISDVAGKAVTTIEGVSGHIAEIVQTSW
TKLDVPQCGYCQSGQVMAAIALLTMNKTPRDADIDDAMSGNLCRCNTYQRIRAAVHDAAK
RLGA
>A0A3G7TLC1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGSPARSCIT
PIGSVVGQNVSTIDNLHSDPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKVNPNPSD
EQIEAAMVGNICRCGTYNRIKTAIRQASSHLKEAQA
>A0A7W9BRZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas prati|TrEMBL
MIEAPAPKRRFRMTRRRMILGGTLAGGALVVGYTATHPMQVAGAILQGGGSDPEPSAFGP
FIRVTPDGWTTIVNRQQELGQGIHAGMAAMIAEELDADWDRVRVIDAHSNLRAYGMQGSA
GSNSIASNWDLMRTAGAAARAMFVAAAAMRWSVPRNLITVRDGVVSHPGSNRSATFAELL
AEAARQTPPQQPSLKHPKDYRLIGTDRVRRKDSLPKSTGAQVYTQDVQLPDMLVAMVAHS
PRFGGRLAKFDSSDARKVKGVVDVIAIETGVAVVAENTFAARQGRDALRTEWNDSAAETR
STPQLVSYYHDIAAGRTDVEPSEFHSKGEDAAAFGAGTIEFAFDFPYLAHAPMETMDCVA
QVDGWDVKIISGSHLPTVDQVQAARVAATIPGRVDVQVIPAGGSFGRRGNLTADYLAECV
RIAKRTNGRPVKLIWTREDEQSSGLFRPMAHHRIWVQLGPDGFPARWRHHVVAQSLLPVG
PNAQAVEGIATSPYLAAARVVDGKVFSPSFPVPVAFFRSVGHSINGMVMEHAIDQLAKRA
GRDPADYRRAMYRRAGAKRHLAVLDELCRKAGWGTPLAAGWARGLAVHEAFGTVVGQVAE
VRMQDGRPIVRRVVAVVDCGIAVSPDQIAAQMEGAIGFGLSAALYGAMTLKDGVVQETNF
DTYPVVRMNEMPAVETYILPSSNRPTGMGEPGVPPIAPAIANAVLALTGAPTRSLPMLPK
GSANFGSGMSPGTTPGATTV
>Q92WL1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium meliloti (strain 1021)|TrEMBL
MIPKLMQSITLPVARAEASRRQFLLGALAAGTGVAIGYRILSASPALAGEAATESGSHAF
SPYLTIGGDGKVTVLSSQFEMGQGSYNGIATLVAEELDSDWSAIDVIGAAGNIKAYGNIA
FGGTMQGTGGSTSMSTSWERYRRAGAAARAMLVAAAAAEWGVDAAEIAVENGVLSHPSGK
SGGFGAFAAKAATMPVPADVKLKEPGDWKLIGNDELKRFDSARKANGTEQYTIDVKLPGM
LTAVMIHPPLFGAKAKSFDASAARAIKGVVDVVETPRGIAVVGEHMWAAIKGREAVTVEW
DETGAEKRGTPELMSTYRDLAGKSPAAFARKDGDTDAAFTSAAKVIEATFEFPYLAHAAL
EPLNAVARRNDDGTIEIWGGHQLPDVYQNLASEIAGVPVEKVRLNVMKTGGSFGRRAVFD
GDVVVEAVHVAKALGFRAPVKVQWTREEDTRAGRYRPAYVHRLKAGIDEAGKLVAWSDHI
VGQSIMAKTAWDGMVQNGVDPTSVEGANNLPYAIANQTVGLTTTDVRVPVLWWRSVGSTH
TAFAAEAFLDEVAEAAGRDPLEFRLSMLEPDSRHATVLKLAAEKAEWQKPLPEGRFRGVA
VAESFGSVVAQIAEVSVDGDGIKVERVVAAVDCGLAINPDQVRAQVEGGIGFGLSAILGE
EITLTDGKVDQGNFDMYTPLRIDAMPKVEVHIVASANPPSGIGEPGVPPIGPAVANAAFK
ALGKRIRVMPFAKSLNA
>A0A1V0Q1W9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MMERLARTAGQDPLAFRLAHIDDPRLATVARRAATMAGWGAPTGRSGLA
>F9YBB4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ketogulonicigenium vulgare (strain WSH-001)|TrEMBL
MGFNTTRRGFLASAGAVAFTIGFGPKGAMAATADAALDPTIGSAIDTAFTPFVRIGTDGQ
VTVLIKHVEMGQGASSGLASFVAEELNHDLGLVKIAFPDAKPEYANTLIGFKGTGGSTAT
PDSFLQYRKAGAAARDMFKAAAAEAWGVDPADVTLENGVLTSGDHSASFAELLQAAATQP
VPEDPKLKETDFRIFGKEGAFRRVDGAGKINGTAIFATDIQLDNQITAMVIRPPRLGAVL
TSFDASGAEGIRGFINAAARADGRGVVVYGENTWAAMSARSAITAEWDFSNAGSRSTDEI
REELLGMVRADPQFNASHDGTDIAAVEADLASAAQVIEAEFFAPYLAHAPMEPMCAVIEP
TAEGGVILHDGTQFAGLSHPTVAAVLGLDPAMVENRPLYAGGSFGRRANFESDYQAEAAE
AFAMTDRTRPVKLAWSREDDIQGGYYRPAFAHRVRVGLDGDGKIVAWDHRLAGQSIMKGS
MFDPNGMEIDHISVEGVADTPYSLGTMHVGLTDQRKDAVVLWWRSVGHSHTGFVMESMMD
MAAEAAGIDPLEFRLNHLPEGEDGDRLRGVLELVTQNANWGNAPEGHGQGLAVVKSFGTY
VAEVVEVSGTADDAIRIEKVTCAVDCGLPINPDMIRAQMEGGIGFALSAVMRGEITMVDG
EVQQTNFYDFMPLRIGDIRAIETHIVPSTASPTGVGEPGVPPAGPALANAIARTGTRVTM
LPLENNGVYFY
>Q46YB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)|TrEMBL
MTSTILDTVREAEAPTPRVQRLALLQARGVLLITRAPQAAARPAAGQPGAASDYVPALPD
IFVAVRDTGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLARVRMVLGHTDATPNQGPTI
ASASIQISAIPLRRAAAQARAWLQARAANQLGVAADALEADDGVFRVKGTQHGIGYGALV
ADEHVELPLADDVQTKPVESYRIVGRGAGRVDIPDKARGVLTFVHDVRVPGMLHGRVVRP
PYAGRDSGDFVGTSLLDVDRNSVRDVPGLVDIVVQGDFIGVVAEREEYAVMAARRLRVHW
KPVPPLPALDDPEPALRANPATRRELLDDGEIPAPDAGTTLERHYTWPYQMHGSIGPSCA
VADWREDGLTVWSGTQNPHVLRIDLARLSGLGEGSIEIVRMDAAGCYGRNCADDVCADAV
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGSNGELLGYDFVSRYPSNDAPTL
ALLLTGQLPNARRMLEMGDRTAVPPYAYSGRRIRCDDTPAIVRASWLRGVSALPNTFAHE
SMIDELAAEAGVDPVDFRLRHLPDNRAADLLRAVAEAAGWQRGANGSRGVPDANGKLHGR
GVAYARYIHSRFPGFGAAWAAWILDLSVDVASGQIVVRKIFVGQDTGMMVNPDGVRHQIH
GNVVQTLSRVLKEQVRFDGDGVASREWGGYPLLTFPEIPPIEVLLMPRQSEPPMGAGESA
SLPGAPAIANALFDATGVRLRRPPFVPETVLAALQGRRP
>A0A1X6YA84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria meonggei|TrEMBL
MALTLKLNGATHTVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLNGEPVRSCQ
TYIEDVEDAEITTIEAVGDDKIGAAVQQAWVELDVVQCGYCQSGQVMSAVGLLSENAKPS
VEEIDTYMAGNACRCATYQRIRAGIQRASDILEA
>A0A0A1F9U8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas arenae|TrEMBL
MTSLNINGKQHEINLPEDTPLLWALRDDVGLTGTKFGCGMALCGACTVHLDGDPIRSCIT
PISAAAGKKVTTIEAMAEDKVGHAVQEAWIALGVPQCGYCQAGQIMSATALLKTTAKPTD
KEIDDAMSGNICRCGTYTRIRAAIKQVADKGVAK
>A0A6J5ENI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia humisilvae|TrEMBL
MLSLNINGRDTEIRSDPATPLLWVLRCELKLTGTKFGCGIGVCGACTLHIDGAAQTCCTK
PVAQLHGVKITTIEGLEGAEARALKAAWTRIDVVQCGYCQSAQLMAASALLKHNHKPGPA
DIDQAMTPVVCRCGTYPRIRDAIYEASGQTRR
>E6PZ69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MAIRLTINQKSHTVNVAPETPLLWVLRDHLQMVGTKFGCGEGMCGACTVLVGGYPVRSCM
TPVSAVADAPIVTIEGLSADGNHPLQRAWMELDVPQCGYCQAGQILTAAALLARSPHPTD
AEIDVAMSGNLCRCSTYTRIRAAIHEAAHQTHQTTTVPSGTAR
>A0A1J5T5V7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MISFNLNGKATKVDVDPGTPLLWVLRDHLHLTGTKYGCGISQCGACTVHLDGKAIRSCVT
PVSTANGKHVTTIEGLAETTLGKAVQAAWLEVDVPQCGYCQSGQIMSATALLKENPHPSE
SQISAAMDGNLCRCGTYNRIRSAIQKASEQLGAAK
>A0A482ZID7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured SUP05 cluster bacterium|TrEMBL
MRIDLSRLHYKELLLGLILCCDLRIDLSRLHYATQNLCILISCDLRIDLSRLHSLDISLG
DGCSCDLRIDLSRLHLPYHVDKQCQSCDLRIDLSRLHLTYSRTSWSECCDLRIDLSRLHS
FILAVLQSSCCDLRIDLSRLHSNASSGHGVYCCDLRIDLSRLH
>H0TPN8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MNFIDNPGKLRGFQRSIRVEKVSRRSVLKGLGISGGFVLAAPLMSRKAFAYETGAGKMPH
GVVVDPRVFVAIAPDGVVTILAHRSEMGTGVRTSLPLIVAEEMEADWSKVRVQQAHGDEA
KFGNQDTDGSRSTRHYLMPMRQIGASARVMLEQAAAKRWGVPATEVKAVNHEVVHDATSR
KLGFGALAADAAKEQVPSIDSLKLKDPKNFRYLTKGQISIVDLHDITTGKARYGADVRLP
GMKYAVIARPPVTGGKLVSFDSAEALKISGVEKVMEVRGWPWPSKFQPLGGVAVIARNTG
AAIKGRDALKIVWDDGPNGQYESVAFRKELEDASRKPGLVVRQDGDADAALKSAEKVIVG
EYYIPHLAHVSMEPPAAVADVKGDKAEIWAPVQSPGGTREDTAKTLDIPEENVTVNVTLL
GGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDVHHGFLHTVSAERIEAGLDKNGKV
IAWRHRSVAPSIASTFAAGTVHQAPFELGMGFVDMPFEIANVTCENPEAAAHTRIGWFRS
VSNIPHAFAVQSMVGELAHATGRDQKEMLLALIGSPRIVQLSSVKDLWNYGEPYDSYPID
TARLRKVVEVVAEKGEWARQLPKGHGLGIAVHRSFVSYIATVVEVAVDEKGKLTVPRVDT
AIDCGTYVNPERIQSQIEGAAIMGLSLAKYGEITFKNGKVQQNNFDDFPVVRIDEAPLVT
NVHIVPPGPETPPSGVGEPGVPPFAPALINAIFAATGKRIRSLPIGKQLET
>H0TLJ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MVTTLTVNGEQKSFDAPPDMPLLWVLRDILGLTGTKFGCGIAQCGACTVHVDGKPVRSCV
LPLSAVRDRSITTVEGVGATPAGAKVQKAWLDLEVVQCGYCQSGQIMSAAALLAVTPSPD
DADIDAAMAGNICRCGTYVRIRAAIKQAASGRQS
>S9REY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger mucosus DSM 16094|TrEMBL
MTLMQKLSRTPVNVSRRGFLRGAGALVLSTTLPVRPGRAQQDGEAASGPAVPAFLELHDD
GTAKLLSPFIEGGQGIYTTFAQTVGEELDLAPENFSVEIAPAGPPYDVMGGFRLTGGSAS
TRTSYNLMRQLGASARAMLIEAAARDWDVPASELTTEPGVVLHPATGRSAPYGMLAKAAM
DLPVPADVPLRDPADFRWIRTPVPRIDVRDKSTGQAKYSIDFEVEGMLLAAVRHAPRLGL
APASVSNQAEIEAMRGVDSVHLLDGAVAVVAEKYWQAVRAVQEAQIEWTEGEAQYPMPAD
FSSDAFRETLAATQGDLAEVESTGDAEAALQSAETVIEATYDAPFLVHGQIEPPSATARF
NEDGTLDVWTTCQAPEMYQGTAAQVAGLERDQVNIHSQMLGGFFGRHFLYATANPFPQAI
QLAKAVGRPVKLIWTREEDFLRDAPRPLGLARFRGAVGPDGPVALSAEVVGEGPTGRWYD
APAGQDASATEGISGKSYAIPNTLIGQVFHPNPAVIGYWRAVGHSMHDFMYEGFLDEMAE
AAQQDPFEMRRALLSGNERLSTLLEAVGTLSGGWQPGPYAAEDGSQRARGVAMASPFGSE
AAAISEVSVDGGEVHVHRVWVAIDPGQIVNPAIVEAQVQSAVALGVSQTLVEELTYENGE
PTARNFDRYSILRPDQMPEVQVEIVESGAPMGGVGEPGLPAVGPSIVNAVARLTGQRVRS
LPLSRHDFGGA
>A0A841QD61|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter lovaniensis|TrEMBL
MSTPAPRPTLASRRQMLGAGGALLLATFWPTPRQSRAQGASVPAGMAPEQGLLVENAQGA
FAPNAYIRIATDNRITLILPNVEMGQGIYTSSVMLIAEELGIDMAQVEIEAAPPGGGAEI
TGGSTSVMTEWLPLRQAGAAARSMLVQAAATHWQVPVAECTTRSATIIHVPTGRSLPFGA
VAAQAATLPVPQKTTLKDPATYTLLGRPQHRIDSAVKVQGHAIFGMDVQVPGQKIGTVAA
CPVVGGTLAGMNKAAALAIRGVQAVLVNTTNTTVCVVADHYWAARKGLRALKPQWHDGPN
AHVTTQTIYDQLHDGLNGPAIVANTKGDAPAVIAHAAATHTATYQQPLLAHATMEPINCT
AHVRPDGCDIWTGTQIADRARDTAIELTGLPKDKVHVHCQYIGGGFGRRLEHEYVTQCVE
FARQVPYPLKIIWSREEDLTHDRYRPAYVDQMTAALDSKGFITALTHRIVGPAVVARWDP
PELTKDGYDEDLSVATVITPYTYPAYRLEFARREAPGVVTAWWRGVGGTRGLFVVEGFID
ELAHRAGADPVAYRRAMLAQNPRALAVLDKAAQAAGWNTPLPPGRARGVAVQFAFGSYMA
SIAEVEMPEPDNVIIHRVTAVVDCGRVLNPDQVISQIEGGLIFGFSAALYNEITLEGGRV
QQSNFNTWRVMRMNEAPCKIDVLLMPSTEDPGGIGEVGTAAAAPVLANAMAAAQGRRYRT
LPLLSPRNGADHKEQG
>A0A7W8S868|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MLTRRTFLLGGASVLGGLLVGWAVVPPRQRLMTSTPLPTQGTQVGLNGWVKIDADNRVTI
MVPKAEMGQGIHTGLAMLLAEELDADWPQVKVEEAPIDRIYNAVQSIVDDLPFRPDDDSY
IRRGTVWITSKAVREIGTMMTGGSSSMNDLWTPMREAGASARVMLIEAAAERWDVPVREC
RAEKGYVLHPWGHKATFGELSSMAARQPLPRSVVLKQPADFRLIGQPVRRIEAASKIDGV
ARFGIDVLPDGLVYASVVMCPTLGGTVAHFDATPAQKIRGFIKAFAVPPYAGGTGGVAVI
ADNAFRAMSAVEAINVSWHDGAAAKVSSAAVDCRLVEALDHTDGHVYYRVGNVDNAMSRA
ARTIEAVYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQMPRLARHHAAKVLGLDVDLVD
VQTQLLGGAFGRRLELDFVAQAAAIAREADGRPVQTIWSRAQDFTHDFYRPACAAWLQAG
FDEHGKLVAWHAKSAGQAIVPDALARYYGVPHIPIDKTTCEGAFDQAYEWPAARVSHKIV
ELPVPIGFWRSVGHSHQAFFTESFTDEAAAAAGQDPIAFRALLLAQHPRHLAVLKRVEKL
SDWGRPLKPAADGARCARGVALHEAFGSVVAQVAEVSIGANRQIRVHRVVGVIDCGLPVN
PNLIRQQMEGGIVFGLSSALQNEITIVNGQVQQKNFVDFPVVRMNGCPAIEVDIMPSQLH
PQGVGEPGVPPIAPAVGNAVFALTGQRLRTLPLRLA
>A0A0K8P4C7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MKAPALAAPSGVAPAAVETADTATAAPESPARRRFLGQGAAGVGALSVGMHLPFLADPAA
AQAAAAAGLPPEINAWVVVRPDDSVVIRIARSEMGQGTLTGLAQLVAEELACDWRRVGTE
YPTPGQNLARQRVWGNFSTGGSRGIRESHELVRKGGAAARMMLVQAAADEWKVPVAECRA
ADGVVTHGPSGRSLRYGALAAAAGRLAPPTEVPLKDPSTWTVVGRPLKRLDTRDKLTGAQ
VYGTDLKLPGLLNAAIRDCPVFGGKLKSFDEAAVRARPGVRQVVRVGDSALAVVADTWWR
AKTALDAAKIEWDAGPNANVSSASIAQMLQAGLDAPEAVVGNRVGDAPAALKTAARTLEA
VYGYPFQNHATMEPMNATARWTAQRCEVWTPTQNGEAALAAAAEAAGLPPAQCEVYKIHL
GGGFGRRGAVHDWVGQAVTIAKALPGVPVKLIWSREEDMLHGRYHPITQCKLRAGLDERG
ELTALHLRISGQSILAGVFPQMVKDGRDPVVFQGLNPPGPEASIGYTVPNLLIDHAMRNP
PVPPGFWRGVNLNQNAIYLECFIDEIAHATRQDPLALRRKLMAKHPKHLAVLNAVAERVG
WDRPAPAGVFRGLAQTMGFGSYVAACAEVSVSPAGELKIHRIVAATDPGHAVNPQQIEAQ
VEGSFVYGLSAALYGECTVAGGRIEQENFNTYPVMRLAEMPKVETITVASGGFWGGVGEP
TIAVAAPAVLNAVFAATGKRVRTLPLRHHDLKRA
>A0A099XX16|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polaribacter sp. Hel1_85|TrEMBL
MPNYTLYINGKERSVTADADTPLLWILRDELNLVGTKFGCGIAQCGACTVHIDGVAIRSC
QMQVSILDDVKITTIEGLSADGKHPVQEAWKEIDVPQCGYCQSGQIMTASAFLEENKNPS
EEEIREAMHGNICRCASYNRIEKAVKVAADKMS
>A0A6I1Z5W8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. RB17|TrEMBL
MPRHTFILNGERVTVDIEDDVRLLWVLRDVLGVTGPKYGCGLGVCKACTSHINGKAFNPC
SVPVKDIGTDDEITTIEGLPGTVGADLHPMQEAWLEYDVAQCGYCQPGQIMTAVAKVRQA
REEGREITEADLDEIRNVCRCGTYHRIRQAITAGEKKY
>A0A7W7QX19|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kitasatospora kifunensis|TrEMBL
MPQHTFILNGAPVTVDVEDDVRLLWVLRDVLGVTGPKYGCGLGVCQACTSHINGKAFNPC
SVPVSAVQPTDQVTTIEGLPATVGKDLHPMQEAWLEYDVAQCGYCQPGQIMAAVAKVQQA
RAAGRELGDADFDEIRNICRCGTYVRIREAIAAGAKNF
>A0A7Y9W1F6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSSDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAADIG
>G8AZ10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum baldaniorum|TrEMBL
MIRLNINGQDRDVDVPGDMPLLWVLRDELNLTGTKFGCGIAQCGACTVHMDGTPIRACQT
PAESAAGTKITTIEGVSGTVAQAVQAAWQKLDVVQCGYCQSGQIMSAVALLTDNRNPTDD
DIDAAMDGNVCRCATYPRIRAAIKDAAKAMGA
>A0A1B2A9D5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tsuneonella dongtanensis|TrEMBL
MHVSRRGLLAGAAVGGGLLVAWGLWPRDYGTPLTPGRGEWAYSAWLKLARDGVLTVAVPQ
LEMGQGVSTILPQVIAAEMGADWRTVAVEPAPVSGAYPNLPLAAKWAPLWMPFAAGLADD
PRKLVLRRWAEMTGFTATAEGTSLAAYEPPAREAAAAARAMLCMAAADRWDVAWEECEVR
GGLVFHGDKHFSFAALAEEAAAYEPPDPPPLNPAPYAEVPDPVTEAAGLRFPRLDLPAKV
DGTFPFAGDVRLPGMLYAAIRHGPIGDTELLGYDEAAAKVRGLRHVVKSRGWIAAVADTW
WAAEKALSAMAPVWRTTGRASSERIATAIDEALTKGEASRVVTRGAGDADNGEPTVTYRY
EIAPATHATIETASATARLADGKLELWMATQAPSHAKAAAAKAVGLSADDAVLYPMAAGG
SFDRRLEHDHAIEAAVIASEVGAPVQLVWSRWQEHVAGRPRAPLACLASAWTAQEDGSPT
GLRLRVAMPSTTAEFGARLFGNKTALAARRATDSAPDPLAFEGALGPYAIPDIAIDHVPV
DVGLPSGRMRGNAPAYLAFVTESFIDELAARVGREPLSFRMAMLGGDPRLAECLQRAARL
GQWDGGAGQSGNGIACWRIGDPEIGGPVARIACVATARAGEGGVRVEKLSVAVDLGRVVN
LDIARQQIEGGLVFGTSLATGSALAYEAGLPTASRLASLNLPQLRDCPEIAVELIPGEGE
PADPGEIGVAVAPPAIANALHSATGLRLRRLPLLSEGL
>A0A2X2CRV4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas luteola|TrEMBL
MTKNVSAQAISLSRRKLLQASGIAAGGLLLATALPFSRRSYAEQYVNKGPEDAPLDTPTA
LGAFLRIGHDGQITLISPKIEMGQGVQTGFAMMVAEELNVTLDQVRVQEAPPDEKLYGDK
LLGFQATGGSSSTRSNWQPLREAAAAARVMLIQAAANQWKVSPDECRAENGKIIGPGNRE
LAYGALVDAAAKLPVPENVPLKKPEDYKVIGQPLRRLDTPGKVDGSAKFTIDLHVPGMKI
ATVSACPVVGGTLASVDDRHARAVPGVRDVVKLENAVAVIGDHMWAALKGLKALEIQWDL
GPNAGIDSAQIERALHAAFDREGAIAAEVGDINKAIAGASSKIEAEYEMPFLAHATLEPM
TCVAQVREDACELWVGTQVPVMAQQAAAKATGLPPEKIIVNNQLIGGGFGRRLEADFIGQ
AAAIAKQVDYPIKLVWTREEDTAHDLYRPHYIDRFSAGLDANGMPVGWSHTIVGASVMAR
FAPAAVPPNGLDADAVEVSNKPVYSLPNLRVRYVPEAPKAILNSWWRGVGPLHGAYVMES
FIDELAYAAKQDPVDYRMKLLGEHPRAQAVLKLAAEKANWSQKLPAGHGRGIAVQEVFGS
YLATVVEMQVDAQNGIHITRLICIADCGEVTNPTSVHSQLEGGTLFGLSAALYNEITVKN
GHVEQSNFHDYRQLRMSDAPPVETHIIPSHEIPGGIGEAGTAMIAPALVNALYAATGKRL
RRLPVVRAGYHVA
>A0A2J7VJI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. B4|TrEMBL
MTRLTLNGKPVDIEGVPDDAPLLWVIRENFKLPGTKFGCGLGQCGACTVHLNGKAIRSCI
TPISAAADQSVTTIEGLDAQHQHPLQRAWVAEQVPQCGYCQSGQIMQAAALLKRTPKPSD
AQIVEAMDGNLCRCGTYQRIKRAIRRASELKA
>A0A7W4VA30|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus alkaliphilus|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAARACI
TPVGSVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACALLKDNPSPRP
EEIRAGITNLCRCGTYPRVERAILRAATALNAGAPKGRASS
>A0A173KX20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium sp. EP60837|TrEMBL
MTKFTVNDRPVQYRMDPDTPLLWALRDASNLTGTKYGCGTGHCGACTVDIDGQAVRSCQV
TIRETEGRFVTTIEGLSPDRGHPLQQVFAADNVSQCGYCIPGMIMTAAVLLKRNADPGDE
EIDAAITNICRCGIYPRLRAAIKRAGKVMRGEEQVEAAPPPGVTPEDAARAVPALRRP
>A0A128F621|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Grimontia celer|TrEMBL
MSVSVNINGQDFELDVPADTPLLWAIRDNLNLTGTKFGCGLAQCGACTVHMGGQPIRSCV
TPVSAVAGQKITTIEGIESKASKAIQAAWEEIQVPQCGYCQSGQIMAASALLASNPSPSD
ADIDAAMNGNICRCATYVRIREAIKQAATELRQG
>S7VXX7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Winogradskyella psychrotolerans RS-3|TrEMBL
MLKITTIEGLSDNGDHPVQEAWKEVDVAQCGYCQAGQIMTAAAMLKKNPSPSEEEVIDGM
NANLCRCGTYHRIKEAVLLASAKIK
>A0A7W8SRJ2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WSM4180|TrEMBL
MSQGLLDAQNGAQLADTDTRHARGISRRGFLKFGVTVGAAAGGGLLLGFSMPAVSQDQKA
GKSVIGGDANEAPQSGVFAPNAFIQIDNAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVP
LGTVTLDHAPPNEKLFMDPLLGGQLTGGSTSIRFAWEPMRRAGATARVMLINAAAQQWQV
DPASCHAQAGQVIHAASNRSASYGQLAQAASALPAPQNVPLKDPKDFKLIGTPAKRLDSP
EKVDGTAQFGLDVRLPDMVYAAIANCPVFGGTLASVDDTHAKTIPGVREVIKLDNAVAVI
GAHTWAAKRGLQALDIKWNEGAGAQVSMKRIVDDLAAASQHGGAVARKDGDVGRAFGDAK
SRLDAVYQQPFLAHATMEPVNATVHVRGDACEIWLGSQVPTRVVDAAVAVTGLPADKIIV
HNHLIGGGFGRRLETDMVTQAVKVGKQVSTPVKVLWTREEDIQHDMYRPYYYDTISAGLD
ANGKPIAWQHRIAGSSIMARFAPPAFKNGLDPDAVEVAADLPYDLPNQLVDYVRVEPHAV
PTAFWRGVGPTRGTFVVESFIDELAAHAKIDPVQYRRDLLGKSPRALNVLNLAAQAGNWG
SALPKGQGRGISVMHAFGSFFAIVVEVAVEQGEVTVKRVNCAVDCGMFVNPNTIEAQVQG
GIIFGITAALYSEITIKDGRVEQNNFTDYRMLRINQTPPIDVHIVKSGEAPGGIGEPGTA
ALAPALTNAIYAATGTRLRQLPVGRQLHNA
>I1XFR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylophaga nitratireducenticrescens|TrEMBL
MNSQLKKESLQTEITNISRRNLLKGFALTGFVLAVGMPFTGFAEDEEAPKYGRDAMPHGW
VDNPLVFVAIAEDGSVTIVSHRSEMGQGVRTSLPMVVADELEADWDRVKVIQAPGDEERY
GNQDTDGSRSVRHFFMPMRNVGAAARMMLEAAAAAHWGVSVDEVFAENHQIKHRASGKML
GYGELAKAAAALDVPERETLRLKTPDQFRYIGKQSTKLIDGEDIVTGKAIYGIDVQVDGM
VHAVIARPPVYGGKVKSFDDSEALKVPGVIKVVTLKGSPPPAVFNPLGGVAVVAENTWAA
MQGREKLKIEWDHGENASYNTEEYRQQMLKDASTSGGKVLRSSGDFAKALETADKTYKAD
YYIPHLSQAPMEPPVATARIQDGKCEVWAPTQAPQASKDTVAKWLEMSPEDVTIHVTLLG
GGFGRKSKPDYLVEAALLSKAMEGRAVQVTWSREDDIHNGYLHTVSIEHLEAAVNADGKT
TAWLHRTVAPSISSTFDASSVHQMPIELGMGVMNIPFAIDNVQIENPEAKAHTRIGWFRS
VANIPRAFAIQSFIAEMAHDLDRDHKAFLLELIGPARKINPVELNDEWNYGESPEKYPLD
TGRLRRVVEAVCEKANWGRDLPAGRGLGLATHYSFVSFTAAIVEVEVSKDGELTIPRMDI
AVDCGPQVNPERIRSQMEGACIMGVSLATVGEISFKDGAVEQDNFDSYQVTRMNESPREI
HVHLLPADDFNTPLGGVGEPGLPPIAPAICNAIFAATGKRIRNLPIRYQLES
>A0A375E5X1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEARADAGVAALDRRSFLKLTGLAGGGLALGVAPLAQAQEGAK
PKAPPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVIT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKGFSADKARAVPGVRGVLPVPVDRGGSGVAVVASGYWPAKMG
RDALEVQWEDAGSKVSSQALFDEYAKLAAQPGTVARAGEGNIAAAINGAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVSGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVEK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNPLSAE
AQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDFPPPRITDAPVVDVFFVPSQDNPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A375FNB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLAMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARVTTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A4P8HVG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MIEVLLNGQAARFDADGEMPLLWALRDIAHLTGTKFGCGMALCGACTVHVDGEPTRACVT
PLRSVADRSVTTIEGIGATAEGRSVQDAWIKVDVPQCGYCQSGQIMSATALLQRVRKPSE
AQITEAMNGNICRCGTYARIRTAIKLAAGKAE
>A0A6V6ZL43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF57|TrEMBL
MTINTSRRGFLKGAAAAGAVLLVGARPDGALAAASSETTQFNPFVKIDADGTVTAIVKHF
EKGQGPATGLPTLIAEEIGLTMDQIEYEFAPSDPNVYNNLLFGPFQGTGGSTAMANSWLQ
YRQAGAAAREMLINAAAQSWSVDASGITIEAGIVKAGDKSAPIAEFVAAASQLEAPAEPR
LKDPSEFRLIGNESVRRKDSAIKGNGQAMYAMDVHVPNQMVAMIKRPESKGGIAKGFDDS
ASKEVKGYINAAILPNQAGVAVYAEDTWAAIQARDALEVEWDMSGGETRDSDQIKAEIMA
ALESEPTYNVNKADVAAVSAAIDGADKVVEKTFYFPLLAHAPMEPLNCTIEQTAEGDIVL
HDGAQMPTGPHMAYQQIFQLPPEKIHIKTMLAGGSFGRRATPDADYQVEAALAFVVTDRS
RPVKLVWTREDDIRSGYYRPAFGHKVRVGLDADGNIVGWQHQIAGQSVIKGTAFEAVLVH
DGVDHSSVEGVADSPYAIPGMALGLTDTPKATTVLWWRSVGHTHTAYTMETMMDLVAEAA
GRDPVEFRLAHLSDSANPDQQRKAAVLKLAVEKAGWGNAPAGRSQGIAVHKSFGSYAAEV
VEISGDAENGIKIEKVTCAVDCGIAVNPDVVKAQMEGGIGYGIGHVMRDQITLTSGAVDQ
SNFPDYEPLRIGDIAAIDVHIVPSAEAPTGVGEPGTPPSAPALANAIHAMTGTLVASHPM
AENGINFV
>A0A1L5NZZ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli 8C-3|TrEMBL
MITLNINGSQHEVDADPEMPILWVLRDTLGMTGTKFGCGAALCGACTVHLDGEAVRSCST
PLSAAEGANITTIEKVTDGTDRVGAAVHAAWVKNDVAQCGYCQSGQIMSATAFLSSLPKG
KQPTADEIDAAMEGNICRCGTYVRIRAAIAEAASTLV
>A0A0L1KCE1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Qipengyuania citrea LAMA 915|TrEMBL
MRFLMDPDTPLLWALRDAANLTGTKYGCGEGDCGACMVHVDGEALRSCLITISEAEGRFI
TTIEGLSRDRSHPVQQALVAEQAIQCGYCTPGIAMAASALLAKTAAPSEAEIKAAIPNLC
RCGVYPRLVRAIERAGRVARRAETISAAPAPGIDARDAAREVPAISAPATRD
>A0A1L5NY97|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium gallicum|TrEMBL
MTTLNVNGHTHEVASEPDTPLLYVLRNDLDLNAAKFGCGLGQCGACTVMVDGQAVLSCVT
PLIVVEGKEIVTVEGLGTLEKPGPLQAAFIEKQAAQCGYCIPGMMMSAAALLKQNATPTD
EDIRSALRTNLCRCGTHMRILAAIRRASELMRAAGLPAAKRSAG
>A0A1L5NTV5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium gallicum|TrEMBL
MVTFTLNGQTKTFDGDSDTPLLWFIRDFEKLTGTKYGCGVAQCGACTVHMDGFTRRSCIT
PISAAEGSEIFTIEGVEGKEAEVVRAAWVAIDVPQCGYCQSGQIMSAVSLLQNIPKPTDE
DIDGAMAGNICRCATYHRIRQAIHNAAAAMEG
>A0A1X7A1Z0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseivivax jejudonensis|TrEMBL
MSRLGTITRRGLVIGAVAVAGGVAFGAWSVRRPHANPLADGLAEGAATFNPWVRIDADAV
TLVTPHSDLGQGARSMQALLIAEEMDLDWGGFRTEYGPPAPAYWNRALADEGAPFMAHDD
GTLAEGTRAAMGAAIKLLGLQITGGSTSVPDSWVKLREAGAVARETLKRAAAAEARVHVR
DVRTEAGAVILPDGTRRPYTALAARAARIDPVTDVTLRDPSAWRLIGQSLPRLDIPAKST
GAQTYGIDLSLPDMLHASVRTNPGRGPLEDFDAEAARAMPGVVDVVEVTNGVAVLAADTW
TAMRAVHAIACRWGPAPYPAEQATHWQRVSDSFTDAALDKEWRHDGDVPGTLTAEAAITA
EYRAPYVAHQPLEPLNATARVADGRVEVWAAHQIPRFVERIAAETAGVAPEAVTFHQQDA
GGSFGHRLEFENIRLAVEIAAQAEGRPVKLTFTREEDFAQDFPRQISIGRARGTVGPEGI
VAVDIEIASASASRSQMARAGQPLPGPDKQIPSGVWNQSYAIPHFRCRAYTVDGLAPTSS
WRSVGASSAGFFWESVVDELLHAAGRDPLEARIAMCTVPHHRATLEAVAEMCDWAGPLGD
GRGRGVAMIESFGVPCAQVVEVEASEAGLRIPRVWVALDVGRVVDPMTFENQVQGGVIWG
LGHAMNSEITYAGGRAEQRNYDAAPAMRLHQAPEIAVRGLETAPEIRGAGEPPVPPAAPA
LANAIFAATGRRLREMPFSREIAFV
>A0A0N0MTY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinobacteria bacterium OK006|TrEMBL
MARQLSRRKFMVYSLAASTLTLAAPVGCDTSSAEGAEPTAAQAHGPSRVLVTGADEEMLV
LEVTAANKVVLRLPRVEVGQGITTAVAMMIAEELDARLVDVDIPLAEARTKGNQYTGGSS
SVRSLYGPARALAATARARLVTAAARRWHLPARRLRTRDTMVVAPDGRTATFGSLTAAAA
RIHRPDVSSRPKPASEHKVIGRPTGRIDARDIVTGKAKYAGDLEVAGAKPTVVARPPTLG
GRLVSVDDRAARAMPGVHAVVKVAGGVAVVAESFHHAFKARDALRITWRPGPLASLSDAA
IRSRLRAAVPSVGPPPRGSAQVEGEFEFAFVSHAPMEVLTAVADVRADRAEIWFSSQTPM
DARESIASAIGLPKSKVRVHVVRGGGSFGRRLNYDAAIEAALISKAARRPVKLMWSRGDD
IRHGRMRGASHHRIRASHAWGRVVAFSHAMASVSESYGGQGLAAQGGVAVRGGVTTVAAG
PLPSDSGLYNFGRVSGSSGSIELAMPLGAWRSVDSGTMRTAEEIVVDEVAAELGKDPVAF
RRGTLRNKAVKAVLDKVAAAGNWGRPLPSGQAQGVAVHEEYGSCVACLVEIDATDPKNPR
VTKVVMAADVGTAVNPRGLEAQLMGTAVDGISTVLRAGLHIDRGAVREGSFADFRYARQQ
HSPLRFEAHIMPSRREPGGAGELGVPAAAGAVANAYARATRTRPRRFPINF
>A0A1Y6KJ88|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ORS 285|TrEMBL
MANLTINGKSYSLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHLDGTAVRSCGV
TVSEAQGKQITTIEGLAADNGLHKVQQAWLENDVPQCGYCQSGMIMAVAALLKDNPKPSD
QDINDAITNICRCGTFAQVREAIHAAANA
>A0A2P9AFG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium delmotii|TrEMBL
MELTINGSTFQVDVEPDTPLLWVVRETLGMTGTKYGCGVAQCGACTVLIDGQATRSCVTT
VDSVVGMAITTIEAIEQDTEGRKVVEAWLANQVPQCGYCQSGQVMAATALLKQTAQPTED
DIAGAMVNLCRCGTYNAISAAVRQAAQA
>A0A388RX05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MDRRDFLKGMGGLVISFSFSTRALAQNADSGRPIASPKPMGKNQLDAWLRIGKDGRVMVY
SGKVDLGTGTRTALAQMVADELDVAFDRIELVMGDTLLTVDQGQTAGSLTIQDGGTTLRR
AAACARRAMTQYAAARWGVPPETLTVSNGIISAGPERQIPYTEVVAAQSFDVPLDSYVPL
KPPGSRRLVGQSVSRVDIPDKLSGRFTYMQDFKLPGMLHARVIRPSGPAARLVGFDAASV
KGVRDLVRIVHKENYLAVVCKSEWSAVKAARMLKVNWLSAENFPDQSALTEYWRSLPVRS
VERPAAKGQVSPALGQAKQRLKATYTFAPHTHGSIGPASAVADFKEGRCTIWSASQATHS
LQGEIASVLGVDKAQVRLIYLDGAGCYGRNGHEDCAADAAFISQAIAQPVRVQWMRADEH
GWDPKSPPTVVDFEGGIDENGRPTAWKSDFYLAAAQGTLSEFPLLAATLSGQKRTGYITA
QIQKNAEVLYAFPNIVTNVHRMQDRAFRTSHLRSPGRLQNSFANEAFFDEMATAAGADPL
AWRLEYLSDTRARTVLEDVARMSAWQYRPAPTPAQLSGGSARGRGLAFLRYDNDRTYVAT
VLDVEVDLKSGKVRVTDVWCSQDCGQVINPDGARNQIEGGIVQTISRVLLEEVRFDRDRI
TTTDWSTYPILRFPEVPNISISLIDRPEAVPWGVGEMAPATIPGAISNAIFNATGIRMRS
VPFLPEKVLALLK
>A0A6G8NSN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Caballeronia sp. SBC1|TrEMBL
MIEIIVNDERHTLDNVPEDMPLLWVLRDRLKLTGTKFGCGGGFCGACTVHLDGNAMRSCV
LPVAAVAGHRITTIEGLSKTGEHPLQRAWVEEDVPQCGYCQPGQLMSAAAFLDGKPVVND
ETITAAMSGNVCRCGTYARIRRAIKRAAPELLSPKKEA
>A0A6G8NWP6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Caballeronia sp. SBC1|TrEMBL
MTTLSINGESHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGQAVRSCVL
PIAAVGERKVTTIEAVSTTPAGKKVQDAWVALDVVQCGYCQSGQVMSAASLIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAVKHAAKGA
>A0A6J4HM12|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Acetobacteraceae bacterium|TrEMBL
GDIGGERHRTPLRGRPGDAAALVSARRVGPHRHQVRLRPGAVRRLHCPRGRFGRAGLPNA
ALGRGGRQGHDHRGPVAGRRAPGPGRVARAQRVAVRLLPNGADHAGGGVPQGHAEPDGRR
HRLGDDRQPVPLRHLPPHPRRHQAGRREGRQDM
>A0A1W7MC17|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MADPALSRRQVLRGASLGAGALVLGLTVRGVSVVAATGAAPASAAFAPDAFIRLAGDGNV
TLVMPQTEMGQGIYTALAMLIAEELDVALEAVKLEEAPADDALYGNPIFKVQATGGSTSV
RGYWPVMRKAGASARAMLIAAAARQWHVPAAECRTEPGEVVHQPSGRRLAYAALAAQAAR
EPVPADPPLKSPETFRLIGHSQRRLDTAHKVDGSLRYGIDATPEGVRFASLACAPVVGGK
VVRVDDRPAKALPGVQQVIVLDDMVAVVAETSWAAMRALAAMDITWNDGPNAALGTADLW
ADLEKASQAEAHVALDTGAAAKLSGDGVIEAHYALPLLAHAPMEPMNCTVHLTSGKCEVW
VGTQVMTMTQRAAAQEAGLSPDQVTVHNHLIGGGFGRRLEVDGVRKAVRIAKHVDGPVKV
VWSREEDVARAPYRSVYGAWLKARIANGKVEAWSHRVVGPSVVARWLPPAYDGKIDSDAV
DGAAETPYDMPALLVDWVRHEPRGVYTAFWRGVGPNMNVFATESFVDRVAREAGQDPLAF
RRNLIGKHQRARAVLDLAAEKAGWGTPLPAGAGRGINLQYVFGTYLCTVAEVVVAEDGTV
AVKRLTTAVDCGSPVNPDGIVSQIQGGMVFGLSAALYGQITLANGRTQESNFHDYRVVRI
DEMPQIEVHIVPSAEAPGGIGEPGTVTVQGALNNAIYAATGIQLSRMPVDPSLLSKSAWR
>A0A1W7M6J9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MSGGATGLSRRGVLRGSAALGLALVVPLGRASGAKAATLTANAFLSVTAEGAALALPKTE
MGQGVFTTLAMLVAEELGLAPAQVAVTIPEGDSARFAPIDQGTGGSSSVRELYKPLRQAA
ANARAALVGAAARQWGIPPERCDLVGGVVIETKGGRRLPVGDLLAAASAAPLPKDAPLRP
SSALRVIGKPTRRLDSLAKVTGETVYGIDVRLPGMKVAMLAQCPMFGGTLATFDEKAART
TPGVVQLVKGSDVLFVVAETYWAAMQGYIAANPQWSAPKGPADHAHILAGLDEALAKPGF
EAKSTGDVAAAKARAARPFSATYRQPFLAHAPMEPGSCTAHVTPEGCTIWAGSQVPAQAR
DDAAKALGLPADKVTFHNCQMGGGFGRRLETDMVVRAVELARQVPYPIKLMWSREEDMKH
DMYRPAYADQITAALDAGGKPIGWEHRIAGSSIMARLLGQGFTGVDADAIEGAVAIPYAL
DAHRVTFQQAESAVPTSWWRGVGGLRSAFVVESFIDELAHAAGQDPLAYRLSLVTDARIR
AVLERAGREAGWGKPLPAGLGRGIAVLQLWGTVIALVLEARVADGAITVPRATVAVDCGL
AINPLGVAAQVESGVIFGLSAALHGEVTIKGGRVEQSNYHDYRILRLNEAPAIATHIVES
AADPGGMGEPPCAVVAPALANAVFAASGKRLRTLPLAMALERVS
>A0A2S6RF36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alphaproteobacteria bacterium MarineAlpha9_Bin4|TrEMBL
MTVLTVNGVNQVVDAPGDTRLLWVIREHLRLTGTKFGCGLGLCGACTVHLNGEAVRSCQV
EIADAEGAMITTIEGLNGGQGGHPVQQAWLELQVPQCGYCQSGQMMNAAAFLAANPSPSD
SEIIEAQQGNICRCITYNRIKTAIRRASDIMQGA
>V4YJV9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Betaproteobacteria bacterium MOLA814|TrEMBL
MKRRHFIVGAAGMGGALLVGWGVMPMRSRQGRPALLPLSAGEVPLNGWLKIASDGMVVLA
MPRSEMGQGVHTALPMLVAEELNMPLAMVKIEQAGADTMYGNVAAFMSALPFHPSDTEGP
ELATHIRASQWLVSKVVRELGVNITGGSTSVADAWEPIRFAAATVRERLRQAAASQWQLP
LDVVRIEDGHVVGGKMRAHFGKLAVQAASVDAVTVRLKQYAAFKLLGKPTHRVDVPSKVN
GQATFGTDVRVPGMVFAVARMAPTLSGDVASLNVAPATGLPGVMQVVQFPPDAQRAGGFA
VVARTTWQAMQGANAVEVTWSPGVGTPPSTQTIAQQLRATVQARDGFAFYDKGDAVAWQA
NAASRLAVTYEAPYLAHATLEPMNCTAQLIGGALKLWVPTQVPTMVRAKAAQVAGIDVEQ
VELVVTQLGGGFGRRLEVDFVAQAVRVAMAMPGQPVQLLWERESDMRHDYYRPMQVATLS
VGLGADGTVDGLRIDSAGDAISPRWMDRALPLLAGPVDMPDKTTAEGLFDLPYDFKHQHM
AHTATNSGVPVGFWRSVGHSHNAFFSESFIDELAYAAKKDPVTFRSDLLQHAPRHLAVLR
SAAQAANWGQVLPGDQAMGVALHESFGSIVAQVARVQAVSDNQWRVLEVHCAIDCGVVIN
PTTVAQQMEGSVVFALTAVAYGQIDIDAGAVIQGNFTGYPMLKLAQTPVVKTHIINSLRA
PSGVGEPGVPPLAPAIGNALFALTKRRHRRLPIDGLSVQ
>A0A7Y7LP43|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MQGAKSKGRRRFILGGLAVTGALVVGWGVTPPRQRLNGSHPLPLGGDSVALNGWVGIDKD
GTVSVAMPRSEMGQGVYTALPMLVAEEMDVPLSAVRLVQAPNDKIFGNIAMLKDGLPFHP
DDTGRLKSSVSWVVGKVARELGLIITGGSSSIKDAWEPMREAGATARAMLVAAAAAEWKT
DAGGLRTADGHVLHADGRKLAYGALAAKAVDAKPGEVRLKSLREFKLIGRPQPRRDTPSK
VNGTAIFGIDARPPGMLYAAVRMSPVIGGTVASVDSAAVLKMPGVVKVVNYDGALPERTG
AGAGVAVIARSYWQAKQAALALDVKWNDGPQAALSSAAIYADFAAKLDKEDGYAYYKAGD
MDAVEGKAAGVAKTVRAEYRAPFLAHAAMEPVNCTAQVKDGKVHVWAPTQSPGFAVEVAA
KVGGVSTDNVVLTVTMLGGGFGRRLDVDMVAQAVAVARQADGHPVQLIWSREDDTTHDVY
RPAALARFSATLDAKGNVLGYDNKSASGSISHQFFKRNLGLPPGGPDKTTAEGEFDMQYH
FPNQRIRHVIVDSAVPIGYWRSVGHSHNAFFKESFIDELAHAAGKDSVAFRRELLAQHPR
HLAVLNAAVAKAGTAPEGRAHGVALHQSFGTIVAQVAEVSVEGTEIRVHRVVCAIDCGLA
VNPNIIAQQAESGVVFGLSAALFGAVTIKDGKVEQSNFHDYPVVRLNQAPEVETVILPSA
EHPEGMGEPATPPVAPAVANAVFKLTGKRLRSLPLTLQGVA
>A0A7Y7HVS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. SG902|TrEMBL
MTDRRSFLKVMAAAGGGLLLQVAIPGARARDGGNAAWQANAVVRIAADGKVHLIMPYIEM
GQGTYTSIPMLIAEELEVDLKDVVLEHAPADDKAYINPALGFQVTGGSTTIRAAWLPMRQ
AGAAARMLLVQAAARQWQVDPSACAAAHGSVAHAASGRKLSYGALAQAAAGLPLPAPEAI
VLKQPKDFRLIGKAQHRLDTPGKLNGSAQYGIDVRLPGMKVAALAITPAYGGRLLGLNEA
AALKVKGVRQVVRLDNCAAVVADNYGAAQKGLSLLELRWDDGPNAQLSTADIVADMARAA
KQGAAKVRSDGEPEQALAKASRVLEATYELPFLAHAAMEPMNCTVHVQPDRCDVWTGTQV
ITRARAVAAKVTGLPEEKVTVHNFLLGGGFGRRLEIDGVEMAVRIAREVKHPVKVIWSRE
EDIQHDMFRPYFYDRVRAGLDEQGMPVAWFHHLTGSSVLGRFLPPAFNNGFDPETLDGAD
SPPYAFKAIRVDYTRHEPPHIPTAFWRGVGPTHNVFVVESFIDELAAAAGKDPLEYRLAL
MRQNPRATAVLQLAAQKAGWNGPRSGDVGRGLSVQFAFGTYMAMVVDAQLVDGEVRVKRV
VCALDCGVVVNPDTVKAQVESAVIFGISGALYGDITFKNGRVEQSNFHDYRVLRMHETPL
IETHIVSSNEAPGGMGEPGTSALMPALANAVYAATGKRIRKLPIATALQAS
>A0A7W6G656|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MSQGKFALTINRKPVSVTADADKPLLWVLREELKMPGTKFGCGQGLCGACTVLLDGQAVR
SCQTPVSAAAGHKVTTIEGASAVPQGAKLVEMWREIDVPQCGYCQAGQILSATALLLANP
KPSDEEIDAGMNGNLCRCATYLRIRRAIRKAAGMADVTGDAA
>A0A654A6F2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia sp. 9I|TrEMBL
MTAPPDPRPGRRRFLAAGGALTLSFVLPLPASAALPGSLEDEPWLDAWIRVGADNRVTIF
TGKVELGQGIKTALLQVAAHELQIDPGRMILITADTERTPDEGYTAGSHSMQDSATAIRH
AAAQVRALLHEKAAAHLKVPAAHLAQDNSVFRAPDGRRVSFSDLVAGSDQHVRATDTLPP
RMPNARRWIGATMERVDIPNKLKGYLAYIQDIRMPAMVHGRVVRPPAPGARLLGVDTSLV
ARMTGVLEVVQDGRFLAVIADEEYRAVKAAKALAQAARWEVPASLPAGRDVAALVRSLPS
APQEVLARGTPGASGRTLRATYTRPYQLHASIGPSCAIALREGSRYTVWTHAQGVFPLRK
ALAEMLGISESALRCIHAEGSGCYGHNGADDAAADAALLARVFPDVPVRVQWMREDEHGW
EPFGPAMVADVAATLGADGRIADWQYEVWSQAHSTRPGKAGNLLPATLLARPFAPPAPKA
IPQPDGGGDRNAIPYYALPNVRVTHRYQGAGPLRTSALRSLGAYCNVFAIESFMDELARA
ANTDPVAFRLRHLEDARAIDVVKLAAAKFAWNGYRKTARRGRGFAFARYKNSAAYCAVAL
EVEVALDTGFVRILRADAAVDCGEVVSPDGVRNQIEGGIIQSASWTLLEQVRFDARGVTS
LDWGGYPILRFNGVPDKVAVHLVDRPGQPFLGTGEASQGPAAAALANAVADAIGTRVRDL
PMNRERMRQLAT
>A0A7W7Z6K4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodopseudomonas rhenobacensis|TrEMBL
MIHDRSILDEKTHAEAGSTLSRRALLQAGAGLAIGVYIAGRTPSFAQNRPAPQSVNILPN
TFLIIAPDDTVTVLCKAIEFGQGPFTGFATLVAEELDADWSQMRAVHAPSNPALYKNLLF
GVQGTGGSSAIANSYEQMRKVGAAARQMLVATAAERWRVAASEISVENGVIKHASGKQGR
FGEFATEAMLRPVPADPQLKDPADFKLIGRDGAVQRLDSAAKSNGSAIFTLDLDEPEMLT
VLIARSPKFGGVVSSFDATAAKQIAGVVDVRQVPTGVAVYAKGFWPAKLGRDALKIVWDD
SKAETRGTREILSEFRALAKTPGKTVKQHGDVDAEFAKGGRLIEAEYVFPYLAHAAMEPL
NGFIKWDGDTALARYGCQFPTPDHGAIAQVLGIGVDKVKLEVLLAGGSFGRRAQQTVHAA
IELAEVAKAIGPGKPLKLVWTREDDMRGGYYRPFGVHRMRGVVRDGKIEGWTDTIVGQSI
MKGTPFEAMTFKDGMDSTTYEGSNEIPYEVANFRCDLHQVDVGVPVLWWRSVGHTHTGYA
VEAFIDELLEAAGQDPVEGRLALMGDNKPRHAGVLKAVAELANWKGAKLEAGRVRGVAVV
ESFNTFVAQVVELSMTEEGPKLHKVWCAVDCGVAVNPDIIRAQMEGGIGFALGHILYAEQ
TIEAGAPVAGNFDKYRSLRINEMPEVEVVIVASGEKPTGVGEPGVPPLGPAVANAMAKLG
LPRPRQLPIVPGATA
>A0A2R8C2R3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria mediterranea M17|TrEMBL
MTLNLKLNGQTHQVEAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHLDGEPVRSCQ
TFIEDVEDAEVTTIEVVDQNSVGAAVQAAWAELDVVQCGYCQSGQIMSAIGLLTENSKPT
LEEIDDYMSGNACRCATYQRIRAAIVLASEKLEA
>A0A509ECJ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium symbioticum|TrEMBL
MFKLTVNGTTHEVDADPDMPLLWVLRDRLDKTGTKYGCGIAQCGACTVHLDGQPVRSCQT
RIGDVGTGAITTIEGVSGRVAEAVQGAWRKLDVVQCGYCQSGQIMSAIGLLSTNPKPSDA
DIDGALDGNICRCGTYQRIRAAIHEAARSLA
>A0A6J5BGE2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sediminicola|TrEMBL
MSQGLLDSQNGAQPLNVRKGGISRRTFLKFGVTVGAATGGGLLLGFSMPAASQDQKTGKS
VIGGDADEAPQNGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVPLDS
VTLDHAPPNEKLFMDPLLGGQLTGGSTSIRYAWEPMRRAGATARTVLISAAAQQWQVDPA
SCHAEAGQVIHAASSRSIGYGQLVTAAAKLPAPQNVKLKDPKDFKVIGTAVKRLDSPEKV
DGTAMFGLDVRVPDMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQVVKVDNAVAVIGDH
TWAAKRGLQALDIKWNEGAGAQVGMKQIVDDLANASQRNGAVARKDGDVNNAFSNAKTRV
DAVYQQPFLAHATMEPINCTVHVRPDGCDVWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LLGGGFGRRLEFDMVTQAVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLDANG
KPIAWQHRIVGSSIMARFAPPAFKNGLDPDAVEVASDLPYDLPNQLIDYVRQEPHAVPTA
FWRGVGPTRGTFVVESFIDELAAQAKVDPVKYRQDLLGKTPRALNVLNTATQAANWGSAV
PKGQGRGVSVMHAFGSFFSIVVDVAVDQGEVAVKRIVCAVDCGMVVNPNTIEAQVQGGII
FGITAALYSEITIKDGRVEQNNFTDYRMLRIDQTPPIEVHIVKSSEAPGGIGEPGTAALA
PALTNAIFAATGKRLRQLPVGSQLQTA
>G0A911|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas fungivorans (strain Ter331)|TrEMBL
MTSLNINGKQHEVDLPEDTPLLWTLRDHIGMTGTKFGCGMALCGACTVHLDGAPIRSCIT
PISAAAGKKVTTIEAIADDKVGHAVQEAWIALGVPQCGYCQAGQIMSATALLKTTPKPTD
KEIDDAMSGNICRCGTYTRIRAAIRQVADKGVAK
>A0A238KBN8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Octadecabacter ascidiaceicola|TrEMBL
MASVGKIARRTFLIGSAAIAGGVAFGTYMVKRPIPNPLLDDLADGEAAITPFVKIAAEGV
TLITPRADKGQGAYSIQAYLIAEELDIDPKDTIRTPGLPGPAYYNAAVMTEGSPLPAYDE
SATAETIRSVLRVIPKLFALQMTGGSSTVPDMYDKLRHAGAVARETLKEAAAIRTGFARA
QLTTENGHVVTPDGDKIAYTDLAVEAAEIDPITDVELRDPKDWRYLGKPGLTRIDMEPKC
TGAEKYGIDLNFDGMLFASICANPGIGGALESFDASAAESMPGVQSIIEVKAGNAGVAVI
ASNTWYAFQAVNAIECEWGAPAYPATSAEIFANLEAAVNKEDNFDHRQRDEGDVDAALAE
GEVFEAQYRIPFLAHAPMEPMNAIVKVTDEKVEIWTGTQIPLFIKNRVAQNLGIEAENVF
VYVQPMGGSFGHKLEMTHVEQAAEVAASVKGTPVKFTWSREEDMTHDYPRPASVMHARGK
IKDGKVDTFDVSVSQSAMAPGWFGRLTGIGIPGPDATITTGSWDQPFAIPNYRVTGYRAP
DMVPVSSWRSVGASGNGFYHDTFLDELIHKAGADPMEERLRLCLHEQSRKVLEEVAELSG
WDGPSMGEDKGRGVAFCLSFGVPTAQVIEVTNTDRGIRIDKAFIVADVGRVLDPMNAEAQ
LTGGMIYALSHAINSELTYENYGPVQNNYHAYEGLRLYQTPQIEVRILENMSGIRGVGEP
GVPPAAPALGNAIFAATGQRIREMPFNKHIDFI
>A0A5B8RF00|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured organism|TrEMBL
MSITLKVNGKTHSVDVDADTPLLWVLRDELRLTGTKYGCGISQCGACTVHLDGSPTRSCV
LPVQSVGDRSVTTIEGLESPAAAAVQKAWAEMDVPQCGYCQSGQVMSAVGLLEQTPQPDD
DAIDGAMRGNVCRCATYQRIRAAIHRAAGELEA
>A0A840F013|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas jinjuensis|TrEMBL
MPVTRRNILIGGGAGIGLIAAWALWPRTYTPRLTLNPGETAFGAWLKIGIDGHVTVVVPQ
CEHGQGVYTALPQIVADELGADWRTVGVEPAPIGPFYANPLALDELFEGNFDRLPAGVRD
TLAKRSALMLTGAATSVRQFEAPLREAAAAARALLCQAAAQRWGIDWNQTRTEAGFVVAG
NRSLRFAELAAEATGFPVPDPLPIGTQGAGKLAGQSVPRLDTPAKVDGSANFAGDVRLPD
MVHAAIRQAPPGDSRLIRVDTAAADRVRGAIAVVQNPRWVAAVATTWWAATRALDAAAPR
FETRGLIDSASIDRALAAAFAQPGHRVAAVGDVDAAMTSGRTIAADYTAAAAVHAAIETM
SAVAAWRDDRLELWMPTQAPSLARAAAAAAAGVSEASVVIHPMLAGGSFGANLEALAAEQ
AAILALRLKRPVSLVWPRAEDLVHDRVRPPARARMAARLAGNGAILGWHARIAAPATGAE
LAHRLMPGAVTDLALAGRRGDPYAVAGAAPPYRLPAMAVDHHPADIGLPTGHLRGGAHGY
TAFFTECFLDEIARASGSEPMSFRIGMLGGNPRLARCLTTAAALGGWDGGTSGGGQGIAA
HAFRGSFIAVLAEAHLDDDGRPAVDRLVAAVDAGRLVNPDLARQQIESGLIFGMAMALGG
ATGYTRNLADARGFASLALPRLADTPDINVEFVPSDEDSGGIGDLGVPAVAPAIANAIHA
ATGQRLRGLPLRAS
>W7WDQ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium sp. T29-B|TrEMBL
MSTRFTLNGKATSVDVDPATPLLWTLRDDLAMTGTKFGCGIAACGACTVHVDGQPTRSCI
TPVSMVAGKKVTTIEAVGNDKVGKAVQAAWIEHDVAQCGYCQSGQIMSATGLLKSNKAPS
DADIDAAMAGNICRCGTYQRIRAAIHDAAKRIA
>A2RW42|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia mallei (strain NCTC 10229)|TrEMBL
MTTDLDLPDAVRASRRTFLKAAGAAAAVGLTIGFEWLDASRPALGATAPAAPAGDAAGAF
APNAFLRVAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDANWRDVRVESAPADASRYAN
LQFGKLQGTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWNVPAAELTTGDGVVRHAAS
RREATYGSLATAAAALPVPEQVALKSPSDFRLIGKPVPRVDARAKSDGTAQFTIDVSMPG
MLVALLQRPPVFGGKVKSFDASAAKAVPGVVSVVQVERSVAVVAKGFWAAKQGRDALKVE
WDESGAEKRSSDAIMREYRQLAERPGASARRDGDAEHALAGAAKRLRASYEFPYPAHAPM
EPLDAVVKLSADRCEIWAGDQFQTIDQGNAARVAGLDPSQVQIHTLYAGGSFGRRANAWS
DYVVEAVSIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHRLDAALSKDGKLVGWRHRI
VGQSILAGTPFEAVMVKNGIDQTSVEGAANLPYAIPNVSVELTTTRSAVPVLWWRVVGSS
HTAYAVEAFIDEAAHAAGKDPYLFRRDLLAHAPRLKGVLELAAEKAGWDPGKPLPKGRGR
GIAVAEAFKSYVAQVAEVSVDEHGAVKVERVVCALDCGTAINPDVIAAQMEGGIGFGLGA
VLHGAITLKDGKVEQNNFDGYRVLRIAEMPKVEVYIVPSGEAPTGVGEPGVAPIGPAVAN
AIFAATGKRHYALPFPAAGEATA
>A0A7Y7I4J9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. SG517|TrEMBL
MPKLKRRHFVLGTVGAVGALVVGWSATPVAPRLVPAQPLPTAPGQVALNGWVKVGSDNTV
TLMMSQSEMGQGTHTGLSMLLAEEMGASLEQIRLETAGSDAIYNNQAAILDALPFRPGDE
GAMKRSTEHVMGKLLRAIPGLSGTGGSSSITDQWMPLREAGASARVMLVGAAAAQWQVPA
AECRAEAGRVLHQASGRSATFGELAPKAAQQPLPAQVALKKPADFKLIGQPARRMDGAAK
LDGSATFGLDVLAPGLLYASIAMCPTTGGRVASFDASAAQKLPGVRKVMALEPVGATLIG
TGATPGGVAVIADTPYHAMRAVKALVIEWDHGPAASLSSAEMIDRLSQTLRTSPGNARLD
DGDVAAAFRSAAKTIEAEYRVPFLAHATMEPMNCTVQFKDGKATVWAPTQAPGFTRSAAA
KALGIDADKVELHVTYLGGGFGRRYSTDFVTQAATLARETAGAPVQLFWSREEDMAHDFY
RPAYVARCRAGFDAAGALVAWQTTTAGSSMGAPSLMDTATDGAWNTAYAFPNARVAHVPV
ESAMPTGVWRSVAHSQNAFFVESFIDECAAAAGKDPVAFRAALLAKDERHMRVLKRVAEL
SNWGQPPAAGPDGAKRARGLAIHRSFGSIVAQVAEVSVSPEKQVRVHRVVCVIDCGVAVN
PNLVRQQMEGAIVYGLSAALHGEITVEKGQVQQSNFHDYMPLRMNECPVIEIDIVAGSEE
PGGVGEPGTPPIAPAVANAVFALTGQRLRSLPLRLV
>A0A3G7U7V6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MNTPIKLPQGLLDLASGEPINLSRRRFLASTAVGALVIGFGLPLGSARVQAATAAERGTQ
VPAFLEIRPDGSVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVESAPPGEAYVVME
NGLRITGGSMSVRMSYPTMRRLGALARAMLLQAAAEQLGVPVAQLTTQPGRVVHTASGRS
LGYGELAGRALDMPVPDPASITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYCIDLKVDGM
LHAAVQHAPRLGMSVGSLRNQAEVQAMQGVHSVHVLPGAVAVVAERWWHAKRAVEAIQVD
WQEAPADSTVRVMPADFSSDKHRDFLAAQQGPARDDENEGDVAGALAGAKTQVQATYHNQ
YLNHAQLEPPSALARYNPDGTLEVWLPNQAPDMFRDDIAKRTGLAAEKITLHSPLLGGFF
GRHFLYESANPYPQAIELAKAVGRPIKLIWTREEEFLRDVLRPVAVVKFRAGLDANGLPV
AIEAVSATEGPTEALAGKQGEKIDPTAMEGLSGKAYAIANKRIAQIYVKGPVMLGYWRSV
GNSLNDFFYEAFLDELADKGGQDPFDLRLHLLRDNPRLTTLLQAVGELSGGWKRGPFTAE
DGSRRARGVAMASPFGSHAAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIIEAQVHGAV
ALGLSQTLIEEAVYVDGKPRARNYDLYPVLPPARMARVHVRIVESGEKMGGIGEPPLPAV
APAVANAVAQLTGQRIRSLPLSRYTFS
>A0A2S2DWL1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aquirufa nivalisilvae|TrEMBL
MKTTRRSFIQKTALLSGVFSLGFDWFESKANAGIIQQMNPVLDANRFNAFLSIENTGKVI
LYSPNPEIGQGIKTAFPIVVAEELDVDWKQVEVRQANLDTQLFERQVTGGSGALKHSWER
LRKAGATARQMLVQAAAQQWGVDASSCKTSKGFVIGPNKGQKLAYGALVDAASKLPVPSE
VTYKSRSDYQLIGSFVKGVDNYKVLTGKPQYGLDTQKSGMVVAQIVRPPAFGSTLVSFDA
AEVKKMPGIIDVVSFKNKVAVVGKSTWEVMQARKKLVCSYSDTSNLESDSTHQKWFDEGM
KTDKVKVERKDGDFHAAIAKAAKVIEATYECPFLSHTPMEPMNFFADVRPGSILLAGPTQ
VPQSAQKAVATLLGVPENTIQVELTKMGGGFGRRLNNDYALEAAELSSIIKMPVKVMWTR
EDDMTGGIYRPAVRYHFKAGLNEKGEMIAFYLRGVGLNAGNSTRQDNFPVGAIDNVLIES
FNYNSAITTGPWRAPITNFLASAEQSFLDEVAVAAGKDPIQMRLDWLQKVKTNPVGKITY
EPDRFIEVIKQVAEKAKWGKKGANVHQGFSVYFSHLSYVAQVAEAKIVDGEAKVTHLTAV
TDCGEVINRSGAENQVIGGIIDGYGHAMFSKLSFDKGVPQQKNFDTYKLIRGNEIPTVEA
HFVNNGIAPTGLGEPALPPTGGAVANALFAATKKRLYRQPFAGPDNANL
>A0A4P6WZN7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hydrogenophaga pseudoflava|TrEMBL
MQIQVNHSVREVPPDWRDESLLVVLREALGLTGTRFGCGAGQCGACTVLIDGQPRRACLM
PVAALGAARVETIEGLAAPDGGLHPVQQAWLDQATPQCGYCQSGQIMATVALLRTHPSPT
AADIDAALSGNLCRCGTQQRIRASVLRAAQATGSGQ
>M4UKY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum FQY_4|TrEMBL
MRIRNLEALAGGGVHDPAAPACADASVATLDRRSFLKLTALAGGGFALGVAPMLAGAQDA
AAKPPSPPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAG
DPYKDPLFGIQLTGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSACRTANGVVI
AGSRRATYGELAQAAMALPVPRQVALKNPSQFRIVGKPTPRLDARAKLDASLKFGIDTRL
PDMKVAVVARPPRFGGKVAKYDAAAAKAVKGVVDVVPIQTDRGGTGVAVIADGYWPAKQG
RDALQATWDDAGSRVSSAALMREYKTLADQPGTVAKAADVGAIQSAAKRIRADYEFPYLA
HAPMEPLNCTIDLQSAGGKVSGAKVWVGTQFQTVDQGALAKALGIAPEKVELNTMMAGGG
FGRRAVPTSDYLVEAANVAKAYAAAGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKGTPFESYMLKNGVDATMTEGVIENDYGFPMQVSVHHPDVDVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPVAYRLARFTDKEHERHRQALRLAVDKSGY
GKRKLPKGQAWGVAVHASFESVVAYVVEVSIDQGKPRVHRVTAGVHANRVINPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGAARNSNFPDFPPVRMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDTV
>A0A839E5F3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halosaccharopolyspora lacisalsi|TrEMBL
MNHPRSPHVEPGSGTVERRRFLGYLLAGPTLVAAAQLGVEPTRAAAAVPSVPEPSEVYDL
NDLLTLAATPTSNLIAVAVHPDGTASFDMPRAESGQGITTVAAMLIAEELDLPLDRINVT
LADARPELVWNQLTGGSNTTIAMYAPIRVAAAIARGRLLKAAAMKLDETVTRLTPHLGVV
RAPDGRTVDYGELAEAAAGRETEQLETELKPESEFRVIGTPRNRTDALEAVTGRKKYAMD
LDVADALPTMVCRPPTIKGTVGSVNNAAEVRRMPGITDVVAISTGVAVRGRTFGQCVTAI
RALDVSWGPGTVDGMSDEDVLADIRKAEIPLAVPDVDPLAETVEGEFTFHFRNNAALEPQ
TAVADVRSDSAEVWAPLQSPILCQELVAEQLGLPVDAVTVHVEQAGGAFGRRFFSDPVIE
AVEVSRKTGKRVKLMWHRVDECRQGRTHPMCTSRIRASLLGDEVLTFEQRHTSVATDYTM
GFGEVITAMAGKIPPLGQGNELVYSDTIFLTTVNVPYKFGAVTQLLNEIYEYDTFPSGSN
RNLVNPDVRTAQELIVDRIAAKTGKDPYRFRREFVDDERVLAVLDKVAEVGDWGREMPAN
TAQGITVHKEYKGAIATLVEIDCSPETVNREIRNAVTGPRVTKAVIAVDTGFAVNPRGLE
AQMQGGLMDGIAQALTSSLHLRDGVFLEGSWDDYFYTRQWNAPLDVQVVVMPPTTGEPGG
AGELGVPSAMASVACAYARATGTMPTSFPINHDALGFAPKPTVPPLPASPTNGLKYAY
>A0A840ZQ06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodinum|TrEMBL
MARLNVNGVVREVEAEPDTPLLWVLREQIGLTGTKYGCGIAQCGACTVHVDGAAVRACSV
PLSSVEPGQKIVTIEGLAPGADHPVQKAWAELDVPQCGFCQPGMIMASAALLAQNPRPSE
AQIRQEITNICRCGTYNRVLAGIKLAAERGQSG
>A0A7W6DAJ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MSYDLQVNGKSYSIDVDGDIPLLWVLRDTIGLTGTKFGCGIAMCGACTVHVDGLPVRSCV
MPVSDAVSKPITTIEAIGETVEGARVQKAWLDIDVVQCGYCQSGQIMSATALLAANSSPT
DEDIDAVMAGNICRCGTYPRIRAAIKLAAAER
>A0A7W7MKN9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes lobatus|TrEMBL
MTITRRGFLGAALVVAVPTPIQDQQIKTVFVRVDARGRITATVPKPDTGQGVRTMAAVLV
AEELAVEVADVTLEQAPGDPATYGPQAVANSTSSRQMAEPLRTAAATARCLLIAAAAARW
QVPVEECTARQGRVRHPAHAPLLYRSLVPAAAALDPASVAVTLTPPERWRLIGRTRAGRS
DARDIVTGRARYGAESAPAGSLVAVVARPPWIGAIPDTVDDSATLAVPGVVAVVRLAAPG
AGQGGVAVVADRTATALRGRELLDVTWTGGTPAADSRVWLDALEAALPAAPGDPAVQRVY
RLPLLAHAPMEPMNATAHVTATGVRVWAPIQDPGGVRTQLARALALPEGQIEVRPTLAGG
GFGRRIETDAVFEAVACSRAAGQPVSVRWTRDDDTRHDSYRPMSVHRLSATLGADGLPAG
RSHQVVTWPLSVSPPFASPVVVKASGDHFPYAVPGDVTVTLRPAPIRTGFWRGVYAGQFG
YAEECFLSEIAQAGGHDQVEFRRRLLPAGSRLRAVLDAAARSHPDPDGVACHLDYGSAVA
VLATVDAAARRVRKVTAAVDVGVPVHPSGVRAQVEGAVLDAVSTVLGAQITVRDGAVTQS
SFRDYAWARITDCPEIAVVLVGSDAPIGGLGELAYPPAAAAIASAFAAYGGPVTGMPYGV
TVG
>G2ZT13|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|blood disease bacterium R229|TrEMBL
MITLDINGKTTRVDAEPDMPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCSV
PVSAAAGKKIVTIEGVDRARVGKAVQDAWKKLDVVQCGYCQSGQIMSAVTLLEGNRKPTN
ADIDAAMAGNICRCATYVRIRAAIHDAAQALA
>A0A7U7EJR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas carbonaria|TrEMBL
MDSVRYLSSSPMNQVDSPGISRRGFLKASAAVSGGLLIGFSMPGLMRDARAEEGEFTPNA
YVRIDREGKIFLTIQPVEMGQGTYTSMPALIAEELEVSLDQVVIEHAPADDKRYANPMLG
FQVTGGSTSVPANWQPLREAGAAARILLVSAAASQWGVSADSCKAENGAVLHPASGRKLG
YGELADAAAKLPLPESVSLKDPKAFKLIGTSARRTDSPDKVNGKAIFGIDARPEGVKVAA
LTLCPVIGGKLDDVDPAPALAIKGVRQVLRTDNSVAVIADHTGAARKGLAALQIKWNEGA
NATVSSEQMLEKIKEASKQPGAQARSEGNVEEALKTAARTVEVTYQVPFLAHACMEPVNC
TVHVRKDGCDLWLGIQVPARAKAVAAELTGLPEDSVQVHNHLLGGGFGRRLDVDFVADAV
KIAKQVDYPVKVIWSREEDTRHSTLRPYHYNHLSAGLDEQGRPVAWTHKVTGASILARWA
PSRFTNNVDGDAVRDACGPYAFPNLAVHYVRHEPPAGILPAFWRGVGHTQNAFMVEGFLD
ELAHLVRADPFEYRYPLLQQHPRALKVLELVREKSGWDSSLESGHGRGLALTHCFGTFAA
QVAEVSVSPNGDVQVHKVTSVVDCGIAINPDSVVAQMQGGTIFGLTAVLFGNITFKDGRV
EQGNFDTYRMLRFNEVPQIETHLVESGESPGGLGEVPTVLIAPAVVNAIFAACGKRLRSL
PIDSQELRQA
>A0A0H2LWF6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax paradoxus|TrEMBL
MLPTHIDPTELPRTLQRLMAAGQQQPEDTAALPRRSFLKLAGVGGLALGAFPHLAVAQAT
GKGPAASALKPAQQPSAFVQIAPNGEVTVTHNRLEFGQGVQTGLPMILAEELDADWSLVR
SKSGTNDAAYHDPVFGMHITGGSNSIKNSFTQYRELGARARAMLLSAAAARWNVDVATLR
TQAGTVLGPNGRKLGYGELAEAAMALPVPEKVTLKDPKDFRLIGRPTTRLDARAKCSGRQ
DFGIDVKHAGQLTAVVAHPPVFGARLASVDDSAARAVKGVKAVLRVPLDRGAEGVAVVAD
GYWPAKLGRDALKLQWDTAAAEKVDSDKQLAQYRELARQPGARKFDADMAPLAKAPRQLE
AEFVFPYLAHAPMEPLNCTVKLSGDRAELWVGTQCAGLDGVAAARTLGLKPEQVRVNVQM
AGGGFGRRFVSTSDVIVEACEIAKAARAAGLNAPVRLLWSREDDVKGGYYRPMHLHHARI
GFDERGKVLAWDHVIVGQSITTGTVFGEFQVKNGIDATATEGMRDPYPLPMRLTVHHPKV
NVPVLWWRSVGSTHTAFVMETLLDEIARSTRQDPVAYRMQLFGDKHPRHRAALQLAVDQS
GYGKKQLPAGRAWGVAVHESFESVVAYVVEASVKDGQPVLHRATAGVHCNLAVNPRSVEA
QVQGAAVMGLSMCLPGAAITLKDGEVQQSNFGDFTVARITDMPEFAVHIVPSAEPPKGIG
EPGLPPLAPAFANAIAQLTGKPLRQLPFNLA
>A0A508SUD2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MIELTVNGIKHQVDVIPEMPLLWVLRDELGITSPKYGCGVAQCGACTVQIDGAAVRSCQA
HIGDLAGKSVVTIEGLENGAQHPVLQAWIEHQVPQCGYCQTGQIMQAISLLELHPKPTDQ
DINEVMSGNLCRCGTYPRIRTAIHAAAAKMAEK
>A0A7Y9HTR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mucilaginibacter sp. E4BP6|TrEMBL
MINITVNGQRHDIDADPNMPLLWVIRDILGLTGTKYGCGVAQCGACTVHLNGEAVRSCVT
KINRAAGQSIVTIEGLSLNNNHPLQLAWNEMNVPQCGYCQSGQLMSAAVLLRENSSPTDQ
DIDDAMAGNICRCGTYQRIRAAIHKAAAMQTGGAKI
>A0A7W9IMD7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptosporangium becharense|TrEMBL
MDEAIGRRRFLGYVLAAPTLVAAAELGPAPAAGAGARLPSPDLTELLDLNDMMTAAALPT
SGLISVEVNQDGTVSFALPRAEVGQGITTSTAMLIAEEMAVPLARVRVTLADARPELLFN
QLTGASNTTIATYTPIRVAAAVARRRLLAAAAAELGSPVTDLTLKAGVITDRSGGSIDIG
ALAGKAASTRNQQVLVELTPRENFTVIGRPHNRIDALDTVTGRKKFAMDLDVADAKPTMV
CRPPTINGRVGSVANLAEVRAMPGVTDVVVISTGVAVRAGTFGQCIDAVRALRVSWKPGT
AEGRTDETVLQELKAAELPIGLRPPTPTVEGRFTFYFRSNSALEPNCAIADVRADRAEIW
SALKSPIVAKQAIAAKLGLPLGRVTVHVTEGGGSFGRKLFFDAALEAAEVSQRIGKPVKL
MWHRADDSRQGRTHPMATSRVRVSYVGDTVLGYEQRHTSVSTDLGHGLGEIITAMAARLP
VGDIGFSQTFFHLSQAMPYRFGAGSRLLNETGKGFNTGSMRNVYSPDVTCARELIVDQLA
TRMGKDPYRFRHDFLRDARSRAVLEKVAEAGDWGRPMPAGTAQGIAFHSEYKAVSAALVE
IDCRPGTVNRPIRDGVTGPRVTKAVFAVDVGLAVNPRGLQAQMMGCIMDGIALALTSSLH
LRDGYFLEASWDNYFYTRQWNTPPELQIIVMPSTSEQPGGAGELGVAASMAAVACAYGRA
TGTMPTSFPINHGTLSFTPKPTVPPVPPSPTDGLDHAR
>A0A1E3H858|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MDDTEAGAVAGLVKIVTLPYGVGVIGTTVEATRRAKDLLKVSWYGSSKASSYTSAERLDA
YTALARNADRTGVAMRSTGDAMAAIAGADRVIEATTAAISSTTRPWSR
>A0A0P1GU87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter sp. CECT 5382|TrEMBL
MSKTLRINGKPHQVDLPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVQVNGEAIRSCQ
LPLGDVEGDITTIEGLGTPDNMAAIQSAWVEHQVAQCGYCQSGQIMQAASLLAENPTPSD
ADIDEAMQGNLCRCGTYPRIRAAIHSAAKMMQEA
>A0A5P9GD67|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF33|TrEMBL
MASVGKILRRTFLIGSAAIVGGVAFGAYYVTRPAANPLKPREGEAALNPFVLIDQNGVTL
FAPRAEMGQGVRTTWAALIAEELDVDLDQITVLHGPAAAAYYNSALVGEGLPNKGYDISN
FQHNLGEALGVLGKTLSLQVTGGSTSMKDGFDRMRQAGASARETLKRAAANRLGVDPSDL
KTASGHVIAPNGDKIAYSMLAEDAAGLEPVEVPLRDPSEWRYLGRSQPRLDMVGKATGTA
EFGVDVRLPGMKFASVRMNPKLGGAMNGFDDSAARSMPGVEKVVDLGTGVAVIANNTWLA
NQAVEAIDVDWGDAPYPPETEEIFARIAEAFDDAPNSTMRDDGDVSASPENATEITAEYR
VPYLAHATMEPMNATALYTGNALELWCGNQAPTLIQFRVANTAGLDIEAVQIHTTYLGGG
FGRRGELDFGEIATKVAMAMPGTPVQTTWSREEDMRHDYFRPGAIARMRGAVQDGKAVLI
DGKVAAQSPTQQAVERYTGFPGGGPDKVLVEGFFNQPYAVPNYRMSGHIADLAVPVGFWR
SVGNSHNGFFHETFMDEMAHAASRDPLEFRLDLMKNEHAPSAGCLEAVKDMSGWTGQTTE
GVGRGVAFTYSFGTPVAQVIEVVDEDGTIRISKAWIACDMGLALDPENVKAQMFGGMMYG
LSAACFGEITFAEGEVEQFNFPDYDAMRMHTAPQVEVRVLETNRHMGGAGEPGTPPSMPA
LGNALFDLTGKRTRSLPLINQFNLLI
>A0A0U5F2Y6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter ghanensis|TrEMBL
MVKFKLNGRDVSVDVPDDTPLLWALRDDLDLTGTKFGCGVGQCGACTVLVGGRATRSCIT
PLSSLEGADVTTIEGLDPNGKHAVQEAWKDIQVPQCGYCQSGQIMQAVSLLKDYPDPTDE
EIDGVMGGSLCRCMTYVRIRKAIKKAAAALRKEEASNG
>A0A0M0EHG1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Komagataeibacter europaeus|TrEMBL
MLTLQINGKSVEVDVDPDTPLLWVLRDVLGMTGTKYGCGIAECGVCTVHVDGRPVRSCSL
PVGLIGPRKAIITIEGLQADPVAAAVRKAWLDIDVVQCGYCQPGQIMAAIALLKKIPNPT
DEQIEAGMSGNLCRCGTYMRIRAAIRNVAAAQGATP
>A0A1D8AV74|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lacunisphaera limnophila|TrEMBL
MPLYHLKINGQSRSVDVAADTPLLWVLRDTLNLLGTKYGCGMGLCGACTVHLNGAPVRSC
QLPVSAIGNTPVTTIEGLDPAGAHPLQKAWCDHDVPQCGYCQSGQIMSAAALLKQTPAPT
DPEIDAAMAGNLCRCGTYVRIRAAIKDAALMAAKGGVS
>S7V9U5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cyclobacterium qasimii M12-11B|TrEMBL
MKLKANKKQSPIKNKAVKAIGNISRRSFFKYMGTGVATYIAWSDVFVASAIQANDKHSTF
PDQELISSWIHISPTGDITVFTGKVEIGQNIRTSLSQVVAEELFVAPEAINMIMGDTALT
PYDRGTYGSLTTLQISPILRMAAANLREILVEEAQKTWGIKSSSLTLSDGMVIDPSSNKR
LAYGDLVKDKQLLRKVNKNVKTIAPEEWKVAGHSIPKINGRDFITGNHRYVSDMVLPGMV
FGKVLRPPAYGAKLLFADTSEAEKIPGVNVVKEGDFIGVTAADTLTAAIALASIESSWDR
SPPVQRSELFEHLVNTAAEKKVVSKGLVDAYDQGDVKLDKSFEVDYIAHVPLETRAGLAS
WENGYLEVWAGTQRPFGLHEDLQKTFDLPVDSIRVYVPDTGSGYGGKQTSEVGVEAARLA
KHVGKPVKVCWTREEEFKWAYFRPAGVIQVRASLSDGEISSWEFHNFNSGSAGIDFPYKG
GKKHLEFHRSSSPLRQGSYRALSSTANVFAMESIVNDLAISLGEDPLRFRLRNLENSRLK
AVVKAAAQAFGWERQKSKDNIGYGMACGTVKGGYVATFVEVEVEKNSRKLIVREVVTAFE
CGVIINPRHLESQVIGCVLQGLGGALFEAVDFKDGNLTNASLASYRVPRFKDVPKMKVIL
LNRADLPSSGAGEAPIVCIAPALRNAIHDASGIKLYKLPMLPSGIVPDNA
>A0A1A7C468|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium psychrotolerans|TrEMBL
MTTLTINGKRHDIALPEDTPLLWTLRDELGMTGTKFGCGMALCGACTVHLDGEAIRSCVT
PISAAAGKNITTIEAVGEDKVGLALQQAWQDHGVPQCGYCQAGQIMSATALLHKTPAPSD
QQIREAMSGNICRCGTYTRIHAAIRQAAGITVKGAAK
>A0A8H2NSV3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGQDQELDVPADMPLLWVLRDVAHLTGTKFGCGIAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSADGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAELG
>A0A5E6R126|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLRGVGATSALVLAASWGWPDAFADEKEKKFGADGMPNGWVDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELDADWALVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECRAQLHKVIHQPSGRELGYG
ELAAAAGALAVPASNSLRLKQPSEFRYIGKESSRAIDGADIVNGRAVYGADVHFEGMLYA
AIARPAVYGGKVKSVDDSAALKVPGVLKVVRIEGRPLPSEFQPLGGVAVVASNTWAAIKG
RDALKIEWDDGPHASYDSVAYRKELEASSLKPGKVVRNTGSIDAAMNDADSTLEASYYLP
HLAQAPMEPMVAVARFKDGACEAWAPSQAPQVTRERIGERLGIAFDKVTVNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPCMNHEAAFELGMGFTNMAYAIPNVRLENPEAVVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RAVLETAAKAAGWGRQLPKGRGLGLAVHYSFVTYVAAVIEVEVMDDGTLVVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEIAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRDLPVRYQLQGWQKADA
>A0A5E6Q0C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNVRIDPSQQASVLDLHEPINVSRRRFLTGTAVGALVLGFGLPLGTTRVQAAVAAATAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPSTFLVEAAPPGEAYV
VLENGMRITGGSMSVRMSYPVMRRLGALARAMLLQAGAQQLGVPVSELSTEPGKVVHANS
GRSLAYGELAERAMDLPVPDPASVKLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKV
DDMLHAAVQHAPRLGMTVGNLRNEEQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTAESKVRPMPADFSSDAWFKRLAEDKGPAKDDEHEGDVAAILKETKTRIDATY
HNQYLNHGQLEPPSALARFNPDGSLEVWLPNQAPDMFRADIAKRTGLDTSRITLHSPLLG
GFFGRHFLYDSASPYPQAIELAKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRAALDSDG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFDLRLHLLRDNKRLTTLLQAVGELSGGWKRGPF
TAEDGSKRARGVAMASPFGTETAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEEAVWMDGKPRARNYDLYPILPPARMARVHVRVVESGEKMGGIGEPPL
PAVAPAVANAVAALTGQRVRSLPMSRHTFT
>A0A5E7VJ88|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPHPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A5E7U6Y2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIAFTVNGERRELDEASSSMPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPAAAVAGHSITTIEGLSLTETHPLQLAWIAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
DSIRNAMSGNICRCGTYGRINKAIKRAANAPKEA
>A0A5E7HPN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PATTVAHRQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A5E7FJJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSQLPMDFALSNLSRRGFLKGVGATGALVVAASWGWQDVFAEEKEKKFGADGMPNGWVDD
PKVYVSIAADGTVTVMCNRSEMGQGVRTSLTMVVADELEADWARVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVSECHAQLHKVIHKPSGRELEYG
ALAAAAGALAVPARDSLKLKQPSEFRYIGKEGTKAIDGDDIVNGRAVYGADVHFDGMLFA
TIARPAVYGGKVKTFDASAAMKVPGVVKVVQIESRPLPSEFQPLGGIAVVANNTWAALKG
REALKIEWDDGANASYDSIAYRKELEAASLKPGKVIRNTGNIDEAMSSADSTLEASYYLP
HLSQSPMEPMVAIARFKDGVCEAWGPSQAPQVTRERIGERLGLPFDKVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWSREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFIDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRL
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKQVAVHL
VTPPGTVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQDWQKAQA
>A0A5E7HGF4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSINPVSRRGFLKGSALLGGGLVVAFVIPGAHRFAVGAENEGNVFAPNAFLRIGNDNVV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLVDAAAKRFNVAPSAIHTESGVVIAGDNRATYGELADDAGKL
PVPDPASIKFKEAKDWKLIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTTMVARSPVFGG
SVKSFEGAEALAVPGVHKVVQVPTGVAVIADHYWAAKLGRDALKVEWDLGPNAGLDSQKL
LESFRKLATTPGVSASKAGDTTAALGKAAKTVDVEYSVPYLAHAPMEPLNCTVKISKDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAG
GPVKTVWSREDDVRGGYYRSAFLHQARIGLDAGGMPVAWKHVMVGQSIMAGTMMEATMVK
DGIDKTSVEGVADSPYLEDLANHQVELHSPTTGISVLWLRSVGHSHTAFVMESLIDELAE
AAGKDPVEYRRTLLKAHPRHLGVLNLAVEKANWKAELPDGHALGVAVHESFGSYVAQVAE
VSQDNLKIRVHRVVCAVDCGIAVNPMSIAAQMESCITFGLGFTLHSKLTFKDGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSTERSGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A4YNW3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MKNAAGERIASHSPDLSRRSFLVGTAATGLVLGYAGLADSALAATTPSAFEPTVWYSIAP
DGLVTVTCGKADMGQHIASTMAQIICEELGAAWKDMRVQLASNDPKFNDPVLGAQITGGS
WSTMMNFDAMSRAGAAGRIALTEAAATAMGVPAKELVVRDGVVMHPKTKKQMSYAEIVKS
GKITKSFTPDELKAITLKTPDQYTMIGVSVPQLDIPSKTNGTAKYGIDTMLPGMVYGKVV
TPPVRFGATVKSVDDSEAKKVPGFIKAVTLDDKTGSTSGWVVAVANTYANARKAADALKI
SYDNGPYANVSTASILAEAKTLQAQDDSGQFFVKDGDATAALSGAAKVLEAEYTTSINIH
APLEPMNATAEFKGDILHIYSGNQFATRSGAIAAGAAGIDPKYVVMHQAWLGGGFGRRLD
ADMMVPAVQAAKAVGKPVKVIYSRENDMTMDYSRPLTYQKVKAGLDSDGKLIALSHDVVS
AWPTARWGIPDFLTPSVDKKGPLDSFTVNGADFFYTVPNHHVRAIKNELAHNATPSGQLR
SVAPGWTFWAVESMIDEIAAASGQDPAQFRIALLDGKGKNDGGAQRLCNTLLAAMGLSGY
GAKKLPKGEGMGVACVSSQERATASWTACVAHVAVADNGAVTVKKLTVATDVGTQVHPDN
IRAQVEGAALWGLSLAMYEKATLKDGGIEQTNFDSYTPLRMSQVPEVAIAVIANGEKATG
VGEPAVTVVAPALGNAIYNACGARLRSLPITAEAVKAAMKA
>A0A7W9ARC0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas yantingensis|TrEMBL
MPIELKVNGRIARVDDDGDTPLLWVLRDTLGLTGTKYGCGIAQCGACTVHIDGQPVRSCA
FPIDAVGASAITTIEGAVGPEADAIRAAWVARDVPQCGFCQSGQIMSAIALLRTAPQPTD
ADIDRAMGGNLCRCATYNRIRAAIHDAARATATPT
>A0A2C9EIX2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MTRPHHSENAGVPMITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACT
IHIDGDPARSCITPIGSVQGKNVSTIDNLHTDPVGQVVQQAWLDTAVAQCGYCQGGQIMS
ATALLKVHPNPSDEQIEEAMLGNICRCGTYNRIKTAIRQASSHLQEAKA
>V4RA76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lutibaculum baratangense AMV1|TrEMBL
MRASARAAFRLSVNGGWHEVEAAPETPLLHVLRNDLGLNGPKYGCGLAQCGACMVLVEGV
ARRACVLPVAQMEGRRIVTLEGLGTPEAPDPVQAAFIAEEAAQCGYCTNGMIMSVKALLA
RTPRPSEQEIRAALRHNLCRCGTHVEILRAVARAVETTEVAPT
>G2PSG4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda ruestringensis (strain DSM 13258 / CIP 107369 / LMG 19739 / B1)|TrEMBL
MATFTLNINGTKQEVDVDPSTPVLWVLRDHLNLVGTKYGCGIAQCGACTIHLDGTATRAC
MLTVSSVGNSEIKTIEGLSEEGDHPVQKAWLEVDVPQCGYCQAGQIMTASALLEKNPNPT
DEEIEMAMNGNICRCGTYTRIKKAVKLAAKS
>A0A1W6KBB8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter salarius|TrEMBL
MAVSLTVNGRERMLDIDSDTPLLWVIRDELGLKGTKFGCGMGLCGACTVHLNGHPVRSCS
TPVELADGGDVTTIEGLSQDGNLHPLQKAWVEHGVPQCGYCQSGQIMSAAHLLQHNDAPS
HDDIVAALSGNLCRCGTYSRIIAAVESVVVDDAARPDRGEA
>U2FLG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haloplasma contractile SSD-17B|TrEMBL
MDISHYFEQLDILHYAEIVLKLVLAVLAGGIIGYERETHHKPVGLRTNILVCLGATIIAI
VGIEIANDVLDQFAKNPDPAFPVKVDLGRLTAQVVSGIGFLGAGSIMRDKNSVSGLTTAA
GMWVSALIGIAIGYGYYFVSGVALLLVVFTLLFNKLKGKTFHSDDEVNGDD
>U2EBH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haloplasma contractile SSD-17B|TrEMBL
MNNRQCKTIITIKSGDTLGNLAVAYNTTVGAILAANKDLDPNDIVIGQDICIPETKDSVC
PIGSIPYKIKAGETLSSIATEYKTTYEQLLLSNPDLNPSNLSVGTVICITQPKLHPTICP
SNNIYVIQEGDAFYKIANTFGVSIDELLRNNPKVDPSNLEVDQVICLPLTRTPYIIVIDL
DERKINLYYLGRFSKSYPIAIGKPTTPTPVGGFRIFNKQVQPGGPFGTRWMGLSAPSYGI
HGTNTPESIGTASSNGCIRMYNRDVEELFSVITINTPVIID
>A0A484V5A5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MRLSVNGQLHTVEAEPAAPLLFVLRNDLALNGPKYGCGLGECGACTVLVDGVAARACVMP
VRGVLGREVTTLEGLGDAACPGPTQQAFIECQAAQCGYCLNGMIMMIEALLRRQPAPDEA
QIRQELRHNLCRCGTHVEILQAARRAVTLHAQARETACAKRSGR
>A0A085GMW7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ewingella americana ATCC 33852|TrEMBL
MSKIKKVAGWGAVAVLAIVIGGATISWQPEIAPLKQPGTQTFSPEKIEQGRKLADLGDCA
VCHTRSGGERNTGGLAMEIPFGTIYSTNITPDVETGIGKWSFAAFKRAMRHGVDREGNYL
YPAFPYTAFTRTSDADLEALYAYLMSQPPVKYSPPETALSFPFNIRQGIVTWNWLFLKPG
ELKTDSSKSAEWQRGEYLTEGLGHCSACHSPRNLMFGEKGGKEHLTGGVAEGWTAPSLVA
NSDAPLKWTHEDFVTFMRSGYSANHGVAAGPMGPVVTEGLSQLPAEDVKAIATYLMSFQS
DSAPQGSAAELNQRAESKVEPLTSEGARLFSGSCMACHAQEKGPQMAGVRPSLALNTNLF
TDSPDNAIRIVLDGIQHPAKAELGFMPAFRHNLSDAQIATLLNYLRQEYAGKAAWPDLQH
KVSEVRAETAVK
>A0A0M7H103|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter aegrifaciens|TrEMBL
MTQLQINGQAKDIDVPGETPLLWTLRDELGMTGTKFGCGMALCGACTVHMDGAPIRSCVT
PLSAVAGHSITTIEGIEADAVGRAVQQAWIEQNVAQCGYCQAGQIMTAVSLLKVSAQPTD
QDIEDAMSGNICRCGTYPRIRAAIQQAARLLAQGGKQ
>A0A2N7RET0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. AD21|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDALAEDAPKKFGAEGMPNGWIDD
PKVYVSIAADGTVTVVCNRSEMGQGVRTSLTMVVADELDADWARVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVSECHAQLHKVLHKPSGRELGYG
ELAAAASALAVPARDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVLKVMQIESRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRQELEAASRKPGKVVRNTGDIEKALSGAASSLEASYYLP
HLAQAPMEPMVAIARYNNGVCEAWAPSQAPQVTRERIAERLGLPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAAVGKDGMPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGVDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPEGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGQRIRNLPVRYQLQGWQKAQA
>A0A1Q8L895|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae706_Ps2|TrEMBL
MGSHTFTVNGEKVTVDVEDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVGALSESDEITTIEGLATGDELHPMQQAWIDKDVAQCGYCQPGQIMAAIDLVKRCSA
EGRSIDDEALDGIRNICRCGTYNRIRKAIKAGADNM
>A0A3B0M3F9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibaca ekhonensis|TrEMBL
MSRLGTITRRTLLVGAVAVAGGAAFGIYQIRKPVENPLTPDQGATLNPYVIIDTSGITII
APRAEMGQGVHTTLAALVAEELDVDFASIRVEHGPPSSAYYNGALMHAALPVADYAMKDW
QHTVVGGLAAASKLLGLQVTGGSTSTVDAFEKMRYAGAGAREALKAVAAERLGVDRAALR
TEGGFVIAPDDTRIPYAELAMDAAARPVPDVGLRPQSDWTLLGRALPRSDMRAKITGQAQ
YATDIPLPGLKFATVRICPHLGGGMAGFDPAPALDLPGVERVIDMGNGVAVIARNTWAAM
EGAKAVQVDWTPAPLPADMDGMFTAIAAAFDTEPNSTLRDDGDTSALPDSAINVEYRVPF
LAHSTMEPQGATAWLQDGQMTIWAGNQAPRICVQVAAEAAGVPEDAITLHTTFMGGGFGR
RAETDAVAQVARIAAEMPGTPIRLTWSREEDMRHDFYRPAAMARMQGAVADGRISHFNAA
IAAPSVTRAAMTRIMGSAPGGADKGHVEGAFDQPYAIPNYRVAGHLADLDVPIGFWRSVG
ASFNGFFHESFVDELAHAAGADPLAFRLAHVAPESAVAAGVLERVRDMSGWDTPLPEGRA
RGVAMTWSFGTPTAVVLEIARAGGRMRVDRAFMACDPGLALDPGIIRAQMESGLIYGLSA
AVMGEITFTDGRADQENFPDYDGLRMFNTPQIDVAILQDNPHMGGVGEPGTPPAAPALAN
AMFALTGTRARSLPLRDVADFVV
>A0A3B0MBP6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibaca ekhonensis|TrEMBL
MDLTINGTNHTVDLPDDMPLLWALRDTLNITSVKYGCGIAQCGACTVHIDGEAVRSCQVA
LADVWGQITTIEGLGTPDALHAIQAAWIDQQVAQCGYCQSGQIMQAADLLARNPEPTDND
IDAAMSGNLCRCGTYPRIRAAVHAAASAMREA
>A0A6S7DUV4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter pulmonis|TrEMBL
MTQLQVNGQARDVTVPDDMPLLWVLRDELGMTGTKFGCGMALCGACTTHLDGQPIRACVT
PVSAVAGRAIATIEGMDADPVGRTVQRAWIENNVAQCGYCQAGQIMTAVGLLKATPAPTE
QQIDEAMSGNICRCGTYPRIRAAIQQAAARLAQGGK
>A0A346BB09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caffeinilytica|TrEMBL
MLKRRTFLLGGAGAFGVLLVGWSVLPPGQRLTPSTPLPAVGNQAALNGWVKIAADNSVTV
MMCKAEMGQGIHTGLAMLLAEELDADWSQVRVENSPIDKIYNSVQAIIDDLPFRPDDDST
VKRATVWMTRKLVRDAGTMMTGGSSSINDLWTPMREAGASARAMLIGAAAAQWKVPSGEC
RTEGGYVLHASGHKASFGELSAMAAQQPLPRKVALKDPADFKLIGKPMRRIEAASKINGT
ARFGIDALPDGLIYASVMMCPTLGGTVAHFDASPARTMPGFIKAFSLKPYGGGSGGVAVI
ADNPFRAMNAVSAINVAWNDGPAVKLSSASVDTRLKQALDDSDGHAYYRQGDVEAALIGA
ARILTAEYHAPYLAHGAVEPVNCTVQVADGAATVWVSTQIPALARQHVAKVLDIDADKVD
VQTQLLGGAFGRRLELDFIAQAAAIAREGGGRPVQTIWSRAEDFTHDFYRPACVSRLKAG
LDKDGKLVAWHATSASQAIVPESLARYYGVPRMPIDKTTCEGAFDQPYEWPAARVAHKIV
ELPIPVGFWRSVGHSHQAFFTEGFTDEIAVATGQDPIAFRAALLAQHPRHLAVLRRVAVL
SDWGRPMTRAADGTKRARGVALHEAFGSVVAQVAEVSVGPNRQIRVHRVVCVIDCGLPVN
PNLIRQQMESGIVFGLSTALQDEITIDGGVVTQKNFLDFPVVRMNDCPVIETDIMPSQMH
PQGVGELGVPPVAPAVANAVFALTGQRLRALPLRLA
>A0A2N7WJE7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia rhynchosiae|TrEMBL
MTTFNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDRKITTIEAVGNTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLIASNPNPSD
ADIDAAMAGNICRCGTYNRIRAAIRHAAKGV
>Q0BGU0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)|TrEMBL
MRFTLNGQPFDFDGDPDTPLLWVIRDSARLTGTKYGCGIGACGACTVHLDGEAARSCVLP
AASVAGRSVTTIEGLSHDRSHPVQRAWIEKDVPQCGYCQSGMVMATAALLARHRKPTDAQ
IDQAVTNLCRCATYQRIREAIHVAAG
>A0A291FXM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter piscinae|TrEMBL
MTANTSRRNFLKGAAASTAVLFVGVNPSGGLAAAGESTAQFNPFVKVGSDGVVTAIVKHY
EAGQGISTGLSTLIAEEIGLRLDQIEFEFAPSNPELYANLRFGIFQGTGSSTSLVNSWDQ
YRQAGAAAREMLIAAAAAAWGNDASDITLDEGNISAAGHSAPIGDFVAAAAQLPTPENPR
LKDPADYKLIGSPAARRLDSASKGNGQAKFAMDVHLPNQMVVLIKRPPSRGALAVSFDDS
AAQDVQGYLHSAVLPNKAGIAVYAENTWAAIQARDAVEAEWDLSAAETRSSDEVEAEIRA
ALDAEPEFRANGTDPDAVAADIKGAEKTIEKTFYFPLLAHAPMEPLNCTIEQTEDGDIVL
HDGAQMPTATHLAYQEIFGLPQERIHIKSMFAGGSFGRRATPSADYQVEAALAFIMTDKT
RPVKLVWTREDDIQGGYYRPAFGHKVRIGLDAKGTIIGWQHQIAGQSVMKGTPFEQIVVH
SGVDHTSVEGAVDTAYSIPGFALGLTDTQKATSVLWWRSIGHAHTAYVMETMMDLAAKAA
GADPLEYRLAYLAGANNKNQQRKSAALKLAADKAGWGKAPAGHAQGISGHMSFGTFVALV
VEVSGNVEDGVKIEKITCAVDCGIAVNPDIVDAQIQSGVGYGIGHIMRDQITLSSGKVDQ
FNFPDYEPLRIGDIGAIDVHIIPSAEAPSGIGEPGTPPAGPALANAVAALAGTMVSTLPM
TENGVTFS
>A0A6S7BLE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pararobbsia alpina|TrEMBL
MQTDKTSQPWPVTRLVVNGKTVDITGPADMPLLWALRDVLALTGTKFGCGIGQCGACTVH
LDGNPVRSCLLPISAVKGEITTIEAVGETAAGKRVQAAWLSLEVVQCGYCQSGQVMSAAA
LIARNPHPNDQDIDAAMSGNLCRCCTYSRIRAAIKAA
>F7QIC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobiaceae bacterium SG-6C|TrEMBL
MPTISINGRNVSVDAANDTPLLWVIREQLQMTGTKFGCGAGLCGACTVHVNGEAVRSCQT
ALSDVAGKKITTIEGLSAKGDHPLQKAWILEQVPQCGYCQSGQIMQAASLLAKNTNPTKE
EVVAHMDGNLCRCMTYSRIQKAIMRAANDMRTASNAPANRSAT
>A0A485IFG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MPTSLVLNGKDITLDVDPNMPLLWAIRESAGLHGTKFGCGMAQCGACTVHLEGTAVRSCV
LPVSAVAGKRVTTIEGIRSKPGKAVQDAWVKLQVPQCGYCQSGQIMSATALLEQNTSPSD
AEIDAAMNGNICRCAAYARIRAAIHEAADTLKA
>A0A4P0ULL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MAVVIEVEVKDDGALLVHKATIAADCGPQINPERIRSQLEGACVMGLGLAALGEISFKDG
KVQQDNFHQYELARMPLAPKAVSVHLLKPDGDLPLGGVGEPGVPPIAPALCNAIFAATGK
RIRELPIRNQLQGWRKA
>A0A0K3BKB1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kibdelosporangium sp. MJ126-NF4|TrEMBL
MAAPVLTVAVPGTADAVVPTLPAPAEILDLGDIGILLGTPTAHMLVVEVGADGVVGLRLP
RAEVGQGITTAVAMLIAEELDTPLDSVRVTLADARPELLFNQLTGGSNAIRSLYGPVRRA
AATARARLLAAAGRLWNLPVGRLNTRDGTVIAPDGRSASFGALTAAAADRTLETAPVTTK
PESAHRLVGTPMSRVDARAMVTGQMRYTLDTDVPGALPTMVRRPPTINGTVRTVRNRAAV
LAMPGVVAVTTIPTGVAVTAETFGQALDGKDALDVTWNPGTVDEVSDADIRAKLRAATPR
LAPPLPLVRHVDAEFDFAFVSHAPLETNCAIADVRDDRAEIWSGLQAPIVAKQTIALALG
LPVDRVTVHVTQSGGSFGRRLFFDAALEAAQVAKAIRRPVKLMWSRIDDMRHGRARPASY
HRIRATVALGQVLSFEHRIAGVETDFRHGMGELLTAAAVHVPVAHTGFAQTFFLTSVHSP
YHFGNTTQQLTEIPLRMHTGSFRSVYSGNTRGAEEIMVDLIAAELGKDPVAFRREFLKTD
RQRAVLDKVAAVGRWGRTMPSGFAQGVAVHDEYKSCTACLVEIDARKPAAPRVTKAVIAV
DVGRPVNPRGLQAQMLGGLTDAIATTLRAGLHIDKGLPLEGSYSQFHYARQRDTPTDVTV
IVMPANGEPGGAGELGVPAAVGAVANAYRRATGTTPHTFPITFPVDFEPFPR
>A0A8F7ZL33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylovirgula sp. HY1|TrEMBL
MQHLTVNGEAHAIDLPPDMPLLWVLRDIIGLYGTKFGCGIAQCGACTVHLDGKPVRSCVL
PIGAIGRRVVTTIEAIGHTTAGKRVQTAWLSLNVVQCGYCQSGQIMSAAALLTRNPHPGD
AEIDAAIRNTCAAGTPAFMPGRSQGNRVKEIRRR
>W6VCK7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. (strain GM41(2012))|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATSALVLVASWGWQEAFAAEKEKKFGADGMPNGWIDD
PKVYVSIGADGMVTVVCNRSEMGQGVRTSLTMVVADELEADWAMMKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVSECHAQLHKVIHKPSGRELGYG
ALAAAAGALAVPARDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAIYGADVHFDGMLYA
TIARPAVYGGKVKSVDSSAAMKVPGVIKVVQIEGHPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKEIEAASLKPGKVVRNTGNIDEAMGSADSTLEASYYLP
HLTQAPMEPMVAIARFKDGVCQAWAPSQAPQVTRERIGERLGIPFDNVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKAGLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAIHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTARM
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAQA
>A0A0D1D5A1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia aquimarina|TrEMBL
MTLSTSRRGFLKGATATGALLFVGLTPQGALAAADGPAMLNPFVKIGSDGTVTAIVKHFE
KGQGPATGLSTLIAEEIGLRMDQIAYEFAPSNPEVYNNLLFGPFQGTGGSTAMANSFMQY
RQAGAAAREMLLQAAASDWGVDASELSIEEGMVTGAGNTAPLGDFVAAASALEAPAEPRL
KDPSEFRLIGDPSIRRLDSAIKVDGSAQFAIDVFLPNQMVVMIARPEQRGALAMSFDDSG
AQGIRGYIRSAVLPNQAGVAVYAEDTWAALQARNALEVEWDLSAAETRSSDEIEAEIRAA
LEEEPTYNVGGPDAAATRAAIDGAANVVEQTFYFPLLAHAPMEPLNCTIEQTEDGRIVLH
DGAQMPTGPHMAMAEIFQLPMDQIEIRTMLAGGSFGRRATPDADYQVEAALAFVMTDRTR
PVKLVWSREDDLRSGYYRPAFGHKVRVGLDEDGEIVGWEHRIAGQSIMKGTPFESVLVHD
GIDHSSVEGTADSPYQIPGAFFGLTDTEKATSTLWWRAVGHTHTAYVMEVMMDMAARAAG
ADPVAFRLNYLTGEGADQRRMAGVLRLAAEQAGWGAAPADRSQGIAVHKSFGSYVAEVVE
ISGNAADGVRIERVTCAVDCGLAVNPDIVKAQMEGGIGYGIGHNMRDRITLTNGAVDQYN
FPDYEPLRIGDIQRIDVHIVPSAEAPTGVGEPGTPPAAPALANAIAAASDLRVGTLPMDE
NGVAFV
>A0A1C7D6P6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraurantiacibacter namhicola|TrEMBL
MLRVSRRGVLAGGALGGGLLVAWALLPRSYSDPLPAEEGETAFGAWLKIGADGVVTVAVP
QLEMGQGVTTLLPQIIARELGADWRQVAVEPAPASGAYANLPLAAEWAPLRRRMVPWLDA
EPDDLLLKRWAQDEAFTATADGTTLAAYEMPCREAAATARAMLAMAAAELWDVDWQECEV
LNGLVTNGERQAGFGALAISAAEQDPPDTPPLRPEEIAELAGSFPMPEGAQTDYPRVDLP
SKVDGTYQFAGDIRLPEMVHAAIRHGPVDRAEISSLDVPATRGIRGLRGIVKGKRWLAAA
ADNWWAAEQALDAMAPRFRTANPVNSQRMNEALDNAVRRGERHRVAERGNGDAGLDKPTL
ALRYDVMPALHAPLETASATARLRDGKLELWMAAQAPEQARQAAAKALGMALEDVILYPV
AAGGSFDRRLEHDHAIEVALIARELDRPVQLTWSRWQEHLLTRPRPPVAGVLAARIDAEG
RIGTFRARLAAPSSSYEFGRRLFGNLTSWAAMEDAEGRPDAMVCQGAMPPYAIPNAAVDH
APARIGLPTGRMRGKADGYTCFMVESFIDEVAQRYAQEPLAYRISMLGEDVRLAECLQRA
ARLAGWGGGGDRSGEGIACHRMGNPATGGRIAVVATAAIGEGGVRVTRLSAAVDIGRVVN
RDLALQQVEGGLVYGLGLALGSATEYQDGLPTQARLGDLGLPTMADMPEVRVELVESESQ
PFDPGEIGVPAVAPAIANAIYSATGLRLRRLPLLSGGL
>D4DXT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia odorifera DSM 4582|TrEMBL
MKLQINETSYEVDAEADTPLLWVIRDDLGLTGTKYGCGLAQCGACTVLVDGVAVRSCVTP
IEGVAGRAITTIEAIETDEVGKRLVQAWISHQVPQCGYCQSGQVMAAAALLKQTPHPSDE
QIAAAMINLCRCGTYNAINAAVHEAATAVTTPDSAVGRGAEQTWTPTHSGAAVATSALAL
AGNDVFHRQPQSVRANDEESGV
>M1WVF9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudodesulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30)|TrEMBL
MISLHVNGKVHEVDVEPDTPLLWVLRDNLGITSVKYGCGEGICGICTVLIDDAAERSCSI
SVESAAGSKILTIEGLPEDHPVKVAWTEKQVPQCGYCQPGMMLQAVDILSKNTAISEKEM
ALAMDDFTCRCGSHPRVVPAMKQAAKSMKK
>A0A840R5V0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania antarctica|TrEMBL
MTHSGFSRRDFIRVSVMAGGGLLVACGGGSSSSRPATPPSNNSGGPPTTPAEEFTLGEFM
RIGTDNRITVLVGATEIGQGALTAIPMIVAEELDADWSLVSAEQSPVAANFNNPYFQNLL
QFTVASSAIRGYFDAQRSVGAAIRQMLINAAAKQWGVNASSLRTEASYVIDDIGGRSASY
GELSSAAANESVPSNPPLKDPASYRIIGTSPQRTDASAKTDGSFKYGMDVDIPGMLTALI
ARPPRFNGQALSVDDNAALAVPGVRSVQTIPGGVAVVADDFWAAQQGRKALQVSWNELLA
GRTDSASQRNDYNLRLNLPGLPIRSDGSTLLAQLQASETLSADYYFPFMAHAAMEPLNVV
VDYDGSSAEIWTGTQSATLDKIFAGVVLGLLPDQINFHMMPAGGGFGRRGNPLADFVRDA
CFVAKALQQPVKVIWTREDDMKGGYYRPAASVRVSASLNSGDEITAWTHRVVTQDVTASL
YVENALDALHDMELPPLAELTDFETGMPYKIDNVLMDAHLTILPTMPSLWMRSVNKFSDV
FAQETFIDELALRVRQNPYAFRRQLLSEKPRHRAVLDAVSQAANWGQSASGVSQGIAVMG
HWNSFIAQVVEVSVSANRELTVHRVVSAVDCGTAINPNLVIAQVESAVIFALSSVLFGEI
LLEDGVVQQSNFDDYPVLRMHQTPIIETVIVNSGNSVGGVGEIGVPCVGPALANAIFAAT
GERIRELPLSRLNFIIA
>A0A0P7W5J6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium HLUCCA08|TrEMBL
MSRIGKIARRSFLIGSAAIVGGAAFGAWYLGRDMPVPEGLAGDGDTALNPFVLIDADGVT
IVTPRAEMGQGTQTTLAALVAEELDVAWEDIRVIHGPPGRAYYNGALLGEALPGAAYARG
RFMHALGDVLGQGGKYLRMQVTGGSTAMVDAYDRLRLAGAAAREALKAAAADRLGIDAAE
LRTENGAVIAPDGTALPYPELAEAAAQVDLREPELRPRSAWRYLGRSMPRLDMAGKVTGT
ATFGIDVRPEGVRFAALRTNPRRAGMVSFEAAEALAMEGVDQVIELPDGIAVIASNTWTA
MRAAEMVEIDWEEASYPPDTEGIFEAIAAAFDTERNSRLRDDGDVTQAPSGGTAVTAEYR
LPYLAHATMEPMGATALFDGDRLTLWSANQAPMLTRKACADALGLPEDAIEVITPYLGGG
FGRRGELDFSVYAAQVARAVPGTPIQLTWSREEDMRHDFYRPGFIARMSGLVAEGRAHSI
DARIAGQSCTQQAMGRWLGRQIGGPDKGHVAGIFDAPYAVPNFRVDGHLAALDVPVGFWR
SVGASANGFFIESFIDEMALAAGADPLAFRLDLARAEWEPAARVLEAVRDMSGWTGQTPD
GVGRGVAMVYSFGTPVAMVVEVTDADGPIRMTRVWIAADPGIALDPGIIEAQLVGGAIYG
FSAAMFEEITFAEGEVQQWNFPDHDALRMHNTPEFEVRILEHQGTLGGIGEPGTPPAAPA
LANALHDLTGTRARELPLHRAFDLLA
>A0A0P7WCY6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium HLUCCA08|TrEMBL
MPTRLTVNGTAHDIDLPDDVPLLWALRDGLGLTGTKFGCGVAACGACTVQIDGEAVRSCS
VALADVWGEVTTIEGLGTPEAMAVIQAAWADHQVAQCGYCQSGQIMQAAALLAQTPDPTD
QQIDDAMMGNLCRCGTYPRIRAAIHDAATRLQEA
>Q3JGA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia pseudomallei (strain 1710b)|TrEMBL
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
ADIDAAMNGNICRCATYTRIRAAIHEAAATLKA
>F9Y765|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ketogulonicigenium vulgare (strain WSH-001)|TrEMBL
MFELSINGQKVSVDVDDDTPLLWVVRDELGMTGTKFGCGIGMCGACTVHIDGVARRSCVT
TVSQAVGVEITTIEGLSADASHPVQEAWRNLRVPQCGYCQSGQIMQAASLLAGNPNPSDS
EIDSAMTGNLCRCMTYVRIRQAVREAVTAINEGAVQNG
>A0A2P9F069|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. MA5143a|TrEMBL
MPSHTFTVNGETVTVEAPDDLPLLWALRDLLGIRGPKYGCGIDVCKACTSHLDGEAVRPC
VVPVSEAAGRRVTTIEGLADGEKLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKRTKNP
TDADIDEIANVCRCGTYFRIREAIKSAAARMG
>A0A7W8UVA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. HC6.4b|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVF
PAAAVGDRKIVTIEALGATPTGQKVQQAWRELDVVQCGYCQSGQVMSAASLLARNPNPSD
ADIDAAMAGNICRCGTYHRVRAAIKHAAKGA
>A0A2U3KXK0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MTRFKVNGVARSFDGDPDMPLLWYLRDILGLTGTKFGCGMSLCGACTVLDNGKAIRSCSK
PMATMEGREITTIEGISAHGPHAVQKAWAEVNVPQCGYCQPGQIMQAVSLLSEKPKPTDD
DIDSAMAGNICRCGTYQRIRAAIKEPAKETA
>A0A852VTW4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janibacter cremeus|TrEMBL
MTDVRPTNPREPSTPGASRRAFIGYVMAGATLATAADMTLGSEPADAAIPTPPQIPEVMD
LNDLLTLAAQPTANLITVTIGEDGRASFALPRAEVGQGIVTSSAMMIAEELDLPVDKVDV
TLAQARPELVFNQLTGGSNTTISTYTPIRVAAALAKQRLLEAAATVLGDTVDALVAKGGL
ITDSTGASIGYGELSAKAAVAETVRAEVNLKSRSQHTVIGTPQRRTDARAAVTGAKVFAM
DLDVPDALPTMVARPPTHNGAPVRLRNQSAITAMPGVTDVAVVPTGVAVRAKTFGQCIDA
VIEMDVEWEGGKLAGEDDASVLANLKNAELPMAVPKVPLLAKQVDAEFTFRFRSNSSLEP
NCAIADVRSGSARIWGSMKSPVVAQEEIAAELGLPISSVNVEVTQGGGSFGRKLFHDAAL
EASRISKAMGKPVKLMWHRADEPRQGRLHPMCTSRVRATHLLGQVLSFEQRHTSVKTDFG
HGLGEIITGQVAKLPVGDLTFSQTIFTLTQEIPYNFGVVTQLLNETDDRFNTGSMRNIYS
PDVRVANELVVDELARSMRKDPVAFRRSFLRNDRARAALDRVAEVGEWGRDLPEGVTQGV
AIHKEYKGVTACLVELDMRPETVNRDIRAAVTGPRVTKVVFAVDAGLVINPTGLDAQMLG
GVMDGIALALTSSCHFDEGHFLEASWDNYFYTRQWNAPPELRVEIMPSQEGQPGGAGEAG
VAASFAAIACAYARATGRMPTEFPINHADPVAFEPKPFVPSVPQSPTNGLNYTY
>A0A0P1GCZ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter multivorans|TrEMBL
MKLTVNGTEHEVDVDPDMPLLWVLRDTLGITGVKYGCGIAQCGACTVHVDGAAVRSCQLP
ISALEGEVTTVEGLSNAETLHAVQEAWLDHQVAQCGYCQSGQIMAAASFLDLNSDPTDAQ
IDQVMSANLCRCGTYPRIRAAVKAAAAKLNEGA
>A0A0P1G957|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter multivorans|TrEMBL
MSRFGKIARRSFLIGSAAVVGGVAFGVYKAKTPFPNPNLDDLAPGSASFNPWVIIDSDKI
TLIAPHADKGQGIFSAQAAMIAEELDVALDDVEISFGVPDRAYYNTAAMDAMAGYPMYDN
SPAAERMRGVLGGVIKLVMPMMATGGSSAIPDSYDKLREAGAIARETLKLAASQNTGVPV
DQLKTEGGAVLFPDGSAVKYTELAELASTIDPVTDVTLRDPKEWKILGKPMKRADMVAKS
TGTLQYGIDFRTEGMLHATVKMNPRQGGALNSYDASAAENMRGVKKILPVQNGVAVVADN
TWRAIQAANTITFDWGPAPYPAEQDDHWHTLAGAFSEEFLNADARTVGDAGAAEGTSVIG
EYRSPYLAHAPLEPLNATVLVTDDRVDIWTGHQIQTMLEQRVADITGHDVENVHLHNMFM
GGSFGHRLEFGFVDQAAEIANQIRGTPVQLTYSREEDFAHDYPRHITMGRGVAKVKDGKV
NALDVQIAGQSVMKSQMGRIGMSLPGPDAQLHEGAWDAPYFNLLNLRVRSYAVENLAPVS
SWRAVGAGPNVFIYETLLDEAIHAAGADPLMERIRLMGHEPSVKVLEAVGDMCNWAGADL
GNGRGRGVAYGFSFGVPVATIVEVVNTDDAIKLEKVWVAGDVGKVIDPVNLDNLAKGGTV
FGLGHAMNCEITYSDGMAEQANYYDFEAMRLNQCPEIEFRALENGEKIRGFGEPPIPPSA
PALGNAIFAATGKRIREMPFNKHIDFV
>A0A0P1GDG5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tritonibacter multivorans|TrEMBL
MSRIGKIARRTFLIGSAAIVGGVAFGAYYVNKAIPNPLLDDLKDGEAAITPYVKIDQTGI
TLITPRADKGQGSYSIQAMMIAEELDVDPTKVTLTPGMPGPAYYNGAVMDEGAPFPAYDE
SWIAERVRGMMFIPAKLMEMQMTGGSSTVKDGFVKMRLAGAVARETLKQAAAQRTGIARA
SLQTADGHVVLPDGSTIAYTDLAADAAKMDPVTDVKLRPETEWKLLGKKMDRLDMADKVT
GQTVYGIDMAVDGMVYATVRANPGIGGDVLSYDDSAARSLRGVQQIVPISHGIGVIADNT
WYAFRAAEALEIEWGAPNYPATTEEIFAELEATVDNEDRFDHRQRNDGDVDAALEAGDVI
EVDYRIPFVAHAPMEPMNAIVQVTDDACHIWTGTQIPLFVRNHAADITGLERDQVYVYVL
PMGGSFGHKLEDTHVQQAVELAMAVKGTPVKLTWSREEDMTHDYPRPAAVAKARGQVKDG
KVETFDLSVAQSSLMTSWFGRLMGPLPGPDATITTGSWDQPFEIPNYRVTGYRAPDMVPI
SSWRSVGASGNGFLHDSFLDELIHAAGADPLAERIRLCMHEPSRKVLEAVKEMSGWDGPS
MGENRGRGVAFCMSFGVPCAQVIEVTNTEGGIKIDKVYSAVDVGTVLDPVNLEAQVFGGV
IFGLAHAMNCETTYENHAAQQDNYHVFEGMRLFQTPEIEVQALTNGDKIRGVGEPGLPPA
APALANAIFAATGQRIREMPFNKHIKFV
>A0A095XW41|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudohaliea rubra DSM 19751|TrEMBL
MYRVMINGTRHEVDAEADTPLLWVLRDFLSLTGTKFGCGMGLCGACTVSLNGRPVRACSL
PLGDVGDAQVQTIESLAASGELNPVQQAWLELDVAQCGYCQSGQIMAATLLLEQNPAPDD
AAIDAAMAGNLCRCGTYQRIREAVKLAASHRTAGGDHG
>A0A7W8Q3H8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia atlantica|TrEMBL
MLTRRTFLLGGASALGGLLVGWGVVPPRQRLMTSTPLPTQGTQVALNGWVKIDTDNRVTI
IVPKAEMGQGIHTGLAMLLAEELDADWSQVHVEEAPIDRIYNAVQSIVDDLPFRPDDDSY
IRRGTVWITSKAVREFGTMMTGGSSSMNDLWTPMREAGASARVMLIGAAAERWDVPVHEC
RAEKGYVLHPRGHKATFGELSSVAAGQPLPRSVVLKQPADFKLIGQPIRRIEAASKIDGA
ARFGIDVLPNGLVYASVVMCPTLGGTVAHFDATPAQKMPGFIKALAVRPYAGGTGGVAVI
ADNAFHAMNAVEAINVSWHDGEAAKLSSTDVDRHLVDALDHTDGHVYYDIGNVDNAMSRA
ARKIEAVYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQMPRLARHHAAKVLDLDVDLVD
VQTQLLGGAFGRRLELDFVAQAAAIAREADGRPVQTIWSRQQDFMHDFYRPACAAWLQAG
FDEHGKLVAWHAKSAGQAIVPDALARYYGVPHLPIDKTTCEGAFDQPYEWPAARVSHKIV
ELPVPIGFWRSVGHSHQAFFTESFTDEAAAAAGQDPIAFRAMLLAQHPRHLAVLKRVEKL
SDWGRPLKPAADGARCARGVALHEAFGSVVAQVAEVSIGANRQIRVHRVVCVIDCGLPVN
PNLIRQQMEGGIVFGLSSALQNEITIVDGQVQQKNFVDFPVVRMNVCPAIEVDIMPSQLH
PQGVGEPGVPPIAPAVGNAVFALTGQRLRRLPLRLA
>A0A852W295|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia antarctica|TrEMBL
MSAPTRARTERRDVSRRRFLGYLVAAPTLVVAAEVGRQQLFAPPGASAAAIPSPPQVADA
YDLLDAVRDSSRPTSALIRVEVNRDGTVSFQLPRSDNGQGIITSTAMIIAEEMDLDPDQV
TVTLADSRPELVFNQLTGGSSTTFSTYTPIRVAAAIAKGRLLDAAAALLQQDVGTLTSRA
GLITGAGGSAIPFGELTEAAAVDATRSVEVVLKPREEFTVIGTDRRNAQARDIVTGRKQF
IADMKIPDALPTVICRGPNLNCAPVSVANADEVRSMPGVTDVVECATGVAVRAHTYGQAV
DGANALRVRWDAGTVEGENDESVLQKVRAAELPLAVPSVPGETVEGDFTFYFRSSSALET
NTAIADVRDGRCEIWTSLKIPITVQHDIAEQLGLPVNAVTIHIVPGGGSFGRRLFGDAAK
EAAEISQKLGKPVKLIWSRADDSRQGRVHPMATSRIRAVVAGESVVSFEQRHTGVSCDFG
HGFGDAVTAAAAKAPLGQVSVAEAIWELTQATPYDFGAQTRVLNEVDMRFNTGSMRNVYS
PDVCTARDLIVDRIAEKMGKDSYEFRREFLRNDAMRAVLDKVAEEGDWGRSMPDGTAQGI
GFHVEYKGFAACLVEIDCRPQTVDRKVRQARTGPRVTKAVFAVDGGLVINPLGFKAQIMG
GINDAIAMTLTSSLHLVDGHFLEASWDNYFYTRQWNTPLDLQVHLVDNGRPEPGGAGEFG
VAPTCGAIANAYARATGRVPDHFPILHHEPLPFEPYPTEPPIPPSPTNGLDFVR
>A0A840BSP5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chelatococcus caeni|TrEMBL
MTIVQSVSRRNFLVGSAAALGGLSLGFHLPLPGKALAADAAPEINAWVVVKPDETVVIRI
ARSEMGQGTLTGLAQLVAEELDCDWARVTTEYPTPGENLARSRVWGNFSTGGSRGIRESH
DYVRQGGAAARQMLIAAAAAEWGVPAAECTTDKGTITHAASGRSTTYGKVADAAGRMTPP
AEVTLKDPKDWTIAGQPLPRLDTADKLTGKQIYGTDLQLDGMLNAAIKACPVFGGKVQSF
DAAAVADMPGVRKVVQVGETAVAVVADTWWRAKTALDALPIVWDEGPNTGVTSATIASML
EEGLDADEAFIGNQAGNAREALAGGAKTVSAVYGFPYQNHATMEPMNATALYTPEKCEVW
VPTQNGEASLAAAAEASGLPVNQCEVYKIHLGGGFGRRGMQDYVTQVVHIAKEFPGTPVK
LIWSREEDMLQGRYHPVTQGKLTGTLDADGNLTALHMRISGQSILAAVMPQRMQDGMDPI
IFQGLTADSPEGHLGYTIPNLLIDHAMRNPPVPPGFWRGVNLNQNAIYLECFLDELAHAA
GQDPLAFRRKLMANHPKHLAVLNAVAERIGWEEPAPEGRHRGLAQIMGFGSYVAAAAEVS
VADGRLRIHRIVAATDPGHAVNPAQIERQVEGSFVYGLSACLYGECTVNGGRIEQENFDT
YDVMRMADMPAVETIVMPSGGFWGGVGEPTIAVAAPAVLNAIFAATGKRIRQLPLKNHSL
V
>A0A564FUE2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium dankookense|TrEMBL
MIKLTVNGASRSFDGDPDMPLLWYLRDELGLTGTKFGCGQALCGACTIHLGGTAARACVT
PVSAAEGQDVVTIEGLSGDGNHPVQAAWRDLNVAQCGYCQCGQIMQAAALLKDTPKPSDD
QIDEAMSGNICRCGTYPRIRAAIHQAAGQTSATKGERL
>A0A7W9W586|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Armatimonas rosea|TrEMBL
MPYKLTVNGRPATVDATADTPLLWVLRDILHLFGTKYGCGIGSCGACTVHVNGEAVRSCQ
TTIAEAAGKKVTTIEGLSPDGKHPLQLAWQEVDVPQCGYCQAGQILSAAALLAKKPRPTD
ADIDEALSGNLCRCGTHMSIRKAVHRAASMTPLPVVKPAAKPAVKPKTGGKK
>A0A1Y5PTS6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Sphingopyxis sp|TrEMBL
MTRFSVNDRPVEYRMDPETPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAIRSCLV
TIAECEGRFVTTIEGLSRDRSHPVQQAWVAEQVPQCGFCQSGMIMSAAALLRANSNPSDA
EIDAAMTGICRCGTYPRIRTAIRLAGRVMRGEERIAAAPPPGIRPEDAARAVPALRPPRG
S
>A0A1J5SGI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MSATTTLDRRSFLQVAAMAGGGLVLGVRFAYAGEETSAEAAKAAFKPNAYIRIGTDNQVW
ISAPNPDLGQGVKTSLPMITAEELCADWNRVVVEQAALDPAAYGWQGAGGSTSTPNNWMR
MRRAGAVGRALLVSAAAKRWRVPASDCVAEQGIVKHAASGRSATFGELASDAAHQRMPDP
ESVPLKERSEFRLLGTRVGGVDNHAIVTGRLQYGIDQVVPGMVYATYVKGPSVAARVKKV
DLDAIRRLPGVKDAFVIEGHGGELAAGVAIIASSTHEAFNAADNAAIVWDESDSPKDDWK
AFVAQAEALGDKDGRVVGERGEPDDALGSSAHVLNASYSYPFIFHATMEPQNCTAWWHDG
IMELWAPSQNPDSGAQEVAKMLGLPQHKVLVHLLRVGGGFGRRLRNDYMVEVAAIARRVN
APVKMTHTRESDLTHDFLRPGGFHHFKGSVNSKGFLEAWTHHFISFGYHGRPVSGGGLGA
DVFPGPLARNFRLTETLLPLGLRTGPWRAPGASAYAWAIQSFLHELSSAAGTDHVAFLLD
ILGEPRWLPPRNEDSLNTGRAAGVIKLAAEKAGWGKPLPPGRGMGIAFHFCHRGHAAEVA
EVSVDASGMLTVHRVVAACDVGPIVNLSGAENQVQGAIVDGLSAMWLQELTFKDGHIEQS
NFNDYGLLRIPQAPKIEVHFIQSDYPPTGLGEPAIPPVAPAVCNAIFAATGKRVRRFPIV
SEGIKV
>A0A1J5Q2C9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MISLNINGKPMRVDADPSTPLLWVLRDHLHLTGTKYGCGIAQCGACTVHLDGRAIRSCVT
PVSMAAGRQVTTIEGLAETALGQTVQGAWQEVDVPQCGYCQSGQIMAATALLKEHPQPSE
AQVSTAMDGILCRCGTYNRIRSAVALASAGLKGDAK
>A0A7W6E2C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter undariae|TrEMBL
MKLNVDGKSHEVDVEDDMPLLWVLRDELGITGVKYGCGIAQCGACTVHIDGVAVRSCQTA
AGDVDGAITTIEGLGTPDALHAVQDAWITHQVAQCGYCQSGQIMQAASLLGENTAPTDAE
IDEAMDGNLCRCGTYPRIRAAVKTAAAKLQGA
>A0A7W6E4T5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter undariae|TrEMBL
MGKLKTIARRSFLIGSAAIVGGVAFGAYLVKRDPENPLALDATDADAVFNPWVKINAEGI
TLVTPHTDLGQGAASMQAMLIAEELDVNLDQVTTSYGRPAAAYYNTAMAGEAVPFRSNDD
SFVAGVARSTVDAVMKVMGAQVTGGSSSVTDSYEKLRQAGAMARETLKAAAAAETGLPIS
DLKTEGGAVVLPDGTRMAYTTLAAKAAQMDLVQDVALRDPSQWRLVGKPVQRMDVVAKST
GTQTYGIDLNIEGMVLASVRMNPRKGAPMRGFDATAAETMRGVSQIVALPYGVAVVADNT
WRAFRALEEIEIDWAEAPYPAEQDDHWAAVAASFTPDRLDKEWRSDGDVEAAFEGAEVFE
AEYRAPYVAHQPLEPLSAIVKVTDDRVDIWAAHQMPRFVQQRVAKRLEMDEEQIHFHNQY
AGGSFGHRLEFINIDVAVDVADKMRGTAVKMIFRREEDFTQDFTRQIGMARGRGAFEGGK
ITALDLEIATVSSSRSQMARLGSSVPGPDMQIVAGAWNMRYSVPNLRVRGYAVPELAPTS
SWRSVGASSAGFFAESFLDELIHAAGADPMEERLRLADDPDARAVLEAVAEMSNWGSPLG
PRKGRGVALVTSFGVPVAEVVEVTDTDDGIKIDRVWLAAEVGRVVDPVTFENVATGGVIW
ALGHAMNSEITYSDGQAEQDNYHLSEGMRLRQCPVIEVRALENNPHVRGIGEPPVPPAAA
ALANAIFAATGTRLRDMPFFNTVDFV
>A0A379ZQI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia marcescens|TrEMBL
MSISQVPLSRRRFIVGAGALVIGAYLPSTGALARSAAPIASGAAALDANAFVQIGADGVV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDTNIYKNLAFGFQGTGGSSSV
ANAYEQMRRMGAMARALLVQAAAQSWKTSAQEITVQAGKIRHAASGREAGFGEFAALAAT
LPPPDPASLTLKDPANFTLIGKARGLHRVDSLAKTNGSAQFSQDIHEPDMLTVTIKKPPR
FGGKVATFDAERALAVPGVVAVKQVATGVAVYAKNTWAAIQGRERLRVTWDDAQAERRNT
EEIYAEFRQVAQKTGVVAKSHGKPDEVFDKADKVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDHKQLCDLFELPPDKVQIETILAGGSFGRRIDLGNPTLGPDLAADM
AAAAKGIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVGWTDTVVGHSWTRH
SAMDALVVNGLDQMMVEGASEVSYTFEAFRCDAHIVPGKVPTTSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPRAAGVLRAVAKAAGWQGAKVVDGRARGVGVAKAFDT
YVAQVAEVSIGEGGIPKVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSLALYGNITLKD
GVVEQSNFNNFRPLRIDEMPEIEVIIVPSTEKPTGVGELGVPTIAPAVGNALALLGRPRT
SLSLPLHNPTANPASDKERT
>Q16DH0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter denitrificans (strain ATCC 33942 / OCh 114)|TrEMBL
MPTTFNVNGNPVTLDVDPDMPLLWALRDHLKLTGTKYGCGIAQCGSCTVMLDGFAARSCV
TTVGDVAGSQVQTIEGVESAAARAVQQAWTTLNVAQCGYCQSGQVLVATELLENTPKPTD
EEIDAAMGANICRCATYARIRKGVRAASDSLEA
>A0A7W9B2T0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis panaciterrulae|TrEMBL
MAGIRDTVGRQSGRAPLVTRRSLLVGATAAGGLALAWSVWPRDYRPNLTAAPDEHIFNAF
LKIGDDGHVSTIVPQCEMGQGVTTLLPQIIADELGADWRTVAVETAPISPLYANTLVVDE
DSAAFMPRAGVPDFVADVRGWVRREWAVRHAVMLTANSSSVRMFEGPCRDAAAQARVLLM
MEAARRWDANWQECDTQDGFVLHQGKRLRFGELAAAAARLTPPDPPVYRASSTDPLYGKE
LTRLDLPAKVDGSANYAGDIRLPDMVYAAIRQGPFGATRLKSIDKKAGLASRDVLYVVEH
ERWVAAVARNWWAANRALDRFAPVFETRGPQISTDRIDAALSSALAADGWRIAQQGDVEG
AMEGRTGIAAEYLVAPALHAPIETRSATAAVDGDRLRVWVATQAPAQCRAAIARATGLAE
SAVILFPMMAGGSFDACLDHSVAVQAAIIARQIKRPVQLAWSRAEEIMRVPPRAPARAKM
TATLNSAGGIDALVSRIAVPATNHEVRARLFDHIPADIAQRNAAGKADAAAVEGAAPLYA
IPHHAVDHCPADIGLPTARWRGNADSYTAFFTECFIDEMATRAGSDALSYRMAMLGDAPL
LARCLLTATTLGGWEGGLSGSAQGLACHAMRGSYIALLATARPSDGGLQVEQLVAVVDAG
RLVNPTIARQQVEGGLIFGLAAAVGATTDYEGGVATARKLHQLGLPKLSQSPEMLIEFVD
SDREPGGLGEIGVPVVAPAIANALFAATGRRIRRLPLSAHPL
>A0A7Y9HT92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MITLNINGKDVQVDADPSTPILWALRDNLNMTGTKFGCGMALCGACTVHLGGQAIRSCVT
PISAAEGQKITTIEAMETDKVGKAVQDAWVKIDVPQCGYCQSGQIMSATALLRTNKNPSD
AEIDNAMAGNICRCGTYQRIRVAIKDAAKAIA
>A0A7Y9HLR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MQGAKNKSRRRFILGGLAVTGALVVGWGVMPARQRLNGSHPLPLEGSSVALNGWVGIGPD
GTVTIAMPRSEMGQGVHTALPMLVAEELDVPLSAVRLVQAPIDKIFGNIAMLKDGLPFHP
DDTGRLKTAVSWVVGKVARELGLIITGGSSSIKDAWEPMREAGAAARAMLVAAAAAQWSV
PAADCRTEDGHVLHADGRKLAYGALAAQAVNARPGEVRLKTPAEFRLIGKPQPRRDTPSK
VNGTAIFGIDARPPGMLYAAVRMSPVIGGTVASMNSAAALKMPGVVKVVDYSAALPPHAG
AGAGVAVIARSYWQAKQAALALAIQWHDGPLAKLSTEAIYADFASRLDKEDGHAYYQAGD
IAAVEGKAAGVAKTVTAEYRAPYLAHAAMEPVNCTAQVKDGEVRLWAPTQSPGFAVDVAA
KVAGVAADKVALQVTMLGGGFGRRLDVDMVAQAVAIARQADGHPVQMIWSREDDTTHDVY
RPAALARFSATLDAAGNVLGYDNKSASGSVSHQFFRRNLGLPPAGPDKTTAEGEFDMQYH
FANQRIRHVIVDSPVPLGYWRSVGHSHNAFFKESFIDELAHAAGKDSVTFRRALLAQHPR
HLAVLNAAVARAGAAPAGRAHGVALHQSFGTIVAQVAEVSVEGTEIRVHRVVCAIDCGLA
VNPNIIAQQAESGVIFGLSAALFGAATIKDGKVEQTNFHDYPVVRLNQAPEVETIILPSA
AHPEGMGEPATPSIAPAVANAVFRLTGKRLRSLPLQL
>S9Q5P9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger mucosus DSM 16094|TrEMBL
MQLNINGTTQDVDVEPDTPLLWVIREELGLTGTKFGCGIAQCGACTVLVDGVPTRSCQTP
ADSVTGTEIRTIETVEETETGRRVVEAWVANQVPQCGYCQSGQVLSATALLTDTPNPSDE
DIEYAMVNLCRCGTYNKIRAAVRDASEA
>A0A0F7KTY0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Croceibacterium atlanticum|TrEMBL
MKISRRAVLAGAAAGGGLVVAWMLMPRDYGSSLEAGPGEAGFGAWLKIDRQGVITVAMPQ
LEMGQGISTLLPQIVAMELGADWRQIAVEPAPVSAAYANYELAARWAPMWRPLLPSLAEK
ADDLMLRRWAEGERFTATAEGTSIANFELPCREAAASARAMLTMAAAERWDVPWQECQAE
NGFIRHGEARLSFAELVEDAGEFDPPDPPPLRPQAPKDGEPEFALEDERHLPFPRLDLPS
KVDGSWLFAGDVRLPDMVYAAIRHGPLDRAEVSSFDREAIAGHPELLGVVNGKRWLATVA
SNWWAAERALDDLAVRFRVTDPVSSAEIAEALDAGVRRGAGQRVGQRGDGDANMVEPTLA
FRYDIMPAAHGTLETASCTARLANGRLELWLATQAPEYAREAAAKALGLSLGDVVLYPMP
AGGSFDRRLEHDHAIEAALIARETGRPVQLVWSRWQEQLRLRPRPPVAATLSARLDSSGR
IEIMRARVAAPPSALEFGRRLFGNATSWGAIADVAGEADAMVLEGLMPPYAIPHVALDHV
PVRIGLPTGRLRGNALGYGCFMMESFIDEVARRQEQEPLSFRISMLGDDLRLAHCLQTAA
RLGNWGGGEAGSGQGLACHRMGDDARSGRIALIATAVAGEGGVRVERLSAAVDIGRVINR
DIALQQIEGGLLFGLGLALGSGMEYDQGLPVQGRLASLNMPSLADSPEIEIELIESDADP
FDPGELPVAPVAPAIANALFSATGLRLRRLPLLSGGL
>A0A841QBA7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter lovaniensis|TrEMBL
MVKFKLNGRDVSVDVPDDTPLLWALRDDLDLTGTKFGCGVGQCGACTVLVGGRATRSCIT
PLSSLEGADVTTIEGLDPNGRHAVQEAWKDIQVPQCGYCQSGQIMQAVSLLKDYPDPTDE
EIDGVMGGSLCRCMTYVRIRKAIKKAAAALRKEEASNG
>A6SW08|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. (strain Marseille)|TrEMBL
MSTVFDNENGNDALNLPALPSMTRRTWLKGAGALTGLALTIGAAGIVRAATSDEVKKYGG
DGMPGGLVDDTLVFVSIAADGIVTIVAHRSEMGQGVRTSLPMVVADELEADWGKVRVAQA
LGMQEKYGNQNTDGSRSMRHSFEPMRRVGAAARQMLEMAAAQQWNVKPTEVQAKNHEVIH
AKTGRRLGYGALAEAAAKITPPAAKDLRLKKPSEFRYIGKESTRGIDFRNIVTGNTQYGI
DTRLPGMLYAVVARPLVMGGKVRSFDASEALKVSGVIQVIELKSSPAPAGFHPLGGIAVI
AKNTWAAIKGREALKITWDDGKHASYNSAEYKKTLQDAARKPAKAVRNNGDTMNVLAKST
RRMEAEYYLPHIAHATMEPPSATAHIVDGKCEVWACVQAPQAAREIVATHLKLKPEDVTV
HVTLLGGGFGRKSKPDFVAEAALLSQAMKGVPVKVTWTREDDIHNDYFHTVSVERLEVAL
DAGGKPTAWLHRTAAPTIASIFSEGAKGEQPFELGMSAVNIPFTIPNFRVEAPEVEAHTR
IGWFRSVSNIPHVFAIQSFVAELAAAAKRDHRDYLLDLIGPARKINPKDMADEWNYGESP
ERYPLDTGRMRNTVTLATNKAGWGRKLPKGHGLGLAVSYSFVTYVAVVIEAVISDKGELS
IPRVDIAVDCGAQINPDRIRSQIEGACIMGLSLALTGEITFKDGRAEQGNFHEYEVMRSM
DAPREIRVHFIKHDFDVPLGGVGEPATPPIAPALCNAIFAATGKRIRDLPLRNQLQASAK
>A0A7W8RWK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MGEIVNLSRRGVLKGTLAGGVVLGLQIGGAGTALAASVLSSANGAKAAFAPNVYVSVAPS
GEIILVVHRSEMGTGIRTSLAMILADELDADWNTVKVVQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGTARQMLVAAAAVQWRVAPATCHTEPGHVVHAASGRRVAYGALATAAARQPV
PGRDTLHLKDEGTWRYIGKSLPIVDLDDIVHGRATYGIDVVLPRMTYASIERSVVYGATL
KSVDSTETMKVPGVLHVVRIPAAPLPAGFQPLGGIAVVATSTWSAMQGRRKLRLDWDLGP
NASYDSQAYRKALEDTARQPGKIVRNNGDTAAALKSAAHHVSADYYVPHLAHAAMEPLAA
TASYANGAVEVWTATQNPQQARTTVAQVLGLQEPAVTINVTLLGGGFGRKSKPDYVAEAA
FLSREVGAPVKLTWTREDDVHNDYFHAVCAQHMEGGLDAQGKTVAWLHRTVFPSISSTFK
ADVRYGAAGELGQGVTDMPYDIANVRCENGAASAHTRIGWYRSVYNIPHGFALGSFVDEL
AAAARHDPVQHLLTLLGTPRHVDLHALGVDYPNYGASIDEYPIDTARYAAVVRAAAVRSG
WSTVLPARHGRGIAVHRSFLSYVAAVAHVQVADDGSVRVTRVDLAVDCGRIVNPDRVIAQ
FEGAVVMALGNTLYSELTFRNGASEQSNFTDYQVARIDSVPETHVYIVPSDAPPGGVGEP
GVPPTSAAICNAIFNATGQRIRALPVDTSLLKRA
>A0A0U1NN83|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nereida ignava|TrEMBL
MSKLKKITRRSFMIGSGLVAGGVAFGAYKVATPHANPLLAELREGEAAFTPFIKITADAV
TLITPHTDVGQGVQTAQALLIAEELDIDLDKVTLSFGAPDPAYYNTALADEAVPFQSADD
SLAARSARGAAGAAFKLLGLMVTGGSSSVPDSYEKLRMAGAVARETLKKAAADQTGQPVS
ALQTKQGAVVLPDGTRIAYTDLAKAAADIAPVTDVSLRDPSEWKRLGKPVLRNDIVAKST
GTQRYTIDLELDGMLHASVRTNPKRGGSAAQYDTAAAEQMRGISAIVPVINGIAVVADNT
WRAIRAVNAIGCEWPDAPYPAEMADHWQAVSDSFTDDALDKEWRNDGDVNAALGKDAKGV
QQIEAEYFAPYVAHQPLEPLCAVARTLETGIEIWIAHQMSRFLQQKVAAVVGCDADEVIF
HQQMAGGSFGHRLEFDVVTQAAEIAVAMKGKPVKLTYSREEDFAQDYVRQISIGRAKGAL
KDGGVHAWQMDIASPSVTASQMTRLGQPAAGPDTQIAAGVWNMPYAVPHLSVRAYRTPEL
APISSWRSVGASSAAFFAESFLDEMIHAAGADPVAERLRLIQSPLHRAVLEAVAEMSDWG
APLGQGQGRGVAIVESFGVPTAEVVQVRDTSRGIVIEKVWVAAEVGQVLDPINFENNVMG
GVAWGLGHAMNCEITFTDGVADQRNFDMHDGIRMAQCPQIEVRGLTNGDKVRGIGEPPVP
PAAPALANAIFAATGQRVRRMPFWNNVDFA
>A0A379IND7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas mendocina|TrEMBL
MGKIETPDSATRGILNVSRRTLLKGSGGLALGIFFAPLLRGMDALAAGGPLEPNAFVRID
LDGTVTVLAKHLEMGQGSYTGLATLLAEELDADWEKVRVEGAPADVKRYNNLAFGPMQGT
GGSTAMANSWEQMRNAGATAKAMLVAAAAQRWGVPASEISVDKGVVSHAGSGRSAGFGEL
VEAAASLPVPEQVQLKDPKDFKLIGKRELRRKDSPGKTDGSAIFTQDFKLPGMLVAMVAY
PPRFGGVPRSVDSSKAKAVRDVVEVVEFRDLPHGRSGVAVLAKNTWAARQGRDALVIDWD
ESQAFTLGSEEILAQYRDSASKPGLPATSKGDADAALAKAAKVVEADYEFPYLAHAAMEP
MNCLVKLSSDRCEIWNGEQFQTVDQAIISSYLGLKPEQVSLTQLYAGGSFGRRASSVSDY
LLEAVAITKAARDKGVDAPVKMVWTREDDTRGGFFRPLYLHRARIGLDEAGKLQAWHNRI
VGQSIIAGTSMEPFLVKEGIDHTSVEGVSNLSYAVPNLQVELSTPTNIKVPVLWWRSVGH
THTGYVAETMIDEAAVAAGQDPYTFRHALLDSHPRHRGALELVAKQAGWDKPLAAGAEGE
KRGRGIAVHESFGSFVAQVAEVTVKADGSYRLDRVVCAVDCGIAINPDVIKAQMEGGIGF
ALAAARHSAITLKEGRVEQSNFHDFQVLRMNEMPKVEVHIVPSAENPTGVGEPGVPPLAP
ALANALFAATGVRLRKLPFPAQIKA
>A0A6P2FGM1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. PBS-H4|TrEMBL
MPILDINGRKHDVDASPDMPLLWAIRDLVGLTGTKFGCGIAQCGACTVHLDGVAARSCVM
PLAAVADRKITTIEGVGATPIGKKVRDAWRALDVVQCGYCQSGQVMSATALIASNPAPSD
ADIDAAMAGNICRCGTYNRIRAAIKQAVKST
>A0A2X5BE98|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia rubidaea|TrEMBL
MKRRDHDLTALDEQPVNLSRRRFLLAGGSLAGALVLGVGLPIGQSRAQAAEAVLAPGTRV
PAFLEIRPDSSVKFLSPFIEGGQGIFTAMAQIVGEELDADPATFIVENAPAGSQYQVMEG
GMRITGGSQSVRASYTTMRRLGALARQMLLQAAAAELSVPVDQLQTEPGRVIHAASGRSL
SYGELAARARDLSVPSPDSVTLKDPARFRWIGKPVQRLDMHEKSTGKAVYTIDCRVDDML
HAAVQHAPRLGLHAGKLRNEDKVKAMKGVHSVHVLPGAVAVVAERWWQAKRAAEALQVEW
LEPDTPDGNYMPADFSSEAFAAVLAQEPGKGEDAEVKGDIAQGMSAAETTLSATYHSQYL
NHAQLEPPSALARFNNDGTLELWIPNQAPEMFQADVAKRTGLAPEKIIIHSPLLGGFFGR
HFVYDTAMVYPQAIALAKAVGRPIKLIWSREEEFLRDTHRPMAAVRFRAGLDAQGYPVAL
EAVSICEGPTEGQAGKHGEQLDPTALEGLTGKAYAIPNVRIAQIYKKGPVKLGYWRSVGN
SMNDFLYECFLDEIADKSKLDPFALRLHLLKGNQRLTTLLNTVAEMSGGWQAGPYTASDG
SRRARGVAMASPFGSEAAAIAEVSIENGQVRVHQVWEAIDPGSIVNPAIIEAQVNSAVAL
GLSQVLLEESVYEKGQPVARNYDMYPILPPSRMAPVQVRIVESGAKMGGIGEPPLPAIPP
AVANAVSRLTGERIRSMPLSRFNFS
>A0A840YYI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stakelama sediminis|TrEMBL
MTRFTVNNQPVAYHMDPDTPLLWALRDASNLTGTKYGCGTGDCGACTVEIDGSAVQSCQV
TIGAIEGAFVTTIEGLSRDRSNPLQQAMIANNVSQCGFCMPGIIMAASVLLKNNPSPDDK
DIEKAITNLCRCGIYPRLTDAIKRAGAIMRGDERIAPSARPGIDAFQAAKSVPALSDRQ
>A0A7W9AIU5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium boeckii|TrEMBL
MAFGDRIRESIGTPTRRQLLVGGGAGVGLLVAWTLWPRRYAPNLIANKGETIVNAFLKIA
ESGVVTVVVPQAELGQGVFTALPQILADELGADWRTIAVEPAPISPVYANRLIAGDLAEG
RGPGFLQGAIRWSAQEYATREALMITSGSSSVRAFEQPMREAGAAARVLLCKAAAAQWDA
DWEACDTAGGFVVRGEERLRFGGLAAAAMAYHLPDPLPMRDGQENRLTGLKLPRLDLPSK
VDGSANFAADVRVPDLAFAAIRQGPVGDTMLKSLDRKAAEAVPGVMGVVDTPHWVAAVAS
NGWAAERALDAMRPLFETRGPWASTKRMTDALEGALDGDGTRFAATGDLGAAFRGQTIHA
AEYAVGLAVHAPMETMTATARFKRDHLEIWLPTQAPAIARAHCAAALGLAEDAVTIHPML
VGGSFGRKLEAEAAVQAAIIAQRMNRPIQLVWSRAEDIAHDLFRPAAQARMSAKLGPGGR
IEGWLAKIAAPATAAEQAARMMAGSGLAGAFIPDPEGADESAIAGAVPPYAISALGVDHH
PAALGVPTGHWRSGAHSYTAFFTECFIDELAIASGVEPLSFRMQMLMGHPRLALCLSAAA
ARGNWEGGVQGSGQGIACHSMAGSHVAIVAEARIEENQTVAVSRVVAAVDCGRVINPDLV
RQQIEGGIIYAIAAATGAPVDFERGLPVLRNFEALEIPRLAQCPEIIVEIIRSNAPPGGV
SEIAVPPVGPAIANAIFAANGQRLRRLPLRTGNT
>A0A7X6J5K3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. SG570|TrEMBL
MGLFGLLDDNRLPTLGRRKFLAGSALVIGFAFANSARALVPTTGLGRAGALDAAATGFDG
FVPDGFIRIGTDGQIVLVVPSAEMGQGIATTEAMLLAEELEVGLDQVEVALAPADPTAYN
QSILKGQITGGSTSVRAFYLPLRQAGAAARTMLVNAAAGLWQVPAAECSAARAVITHNPT
GRAASYASVAEAARSQPVPKDVQLKKPGEFKLIGKPLKRVDTPEKVTGAVKFGIDVMVEG
MRYAAITICPTIGGKVKSVDDTASRASPGVIDILRIEDAVAVVGETYWAAKKGLDLLAVE
WDLGPNADMSSDDLWDGLRNAKATPIVGKVVGDPDIALASGVRIESTYELPYLAHAALEP
INTTIHMQGDRCDIWVSTQVPEIARVVAAEILGLPIEKVTVHPHLIGGGFGRRLAVDTIQ
QAARFGKLANYPVKIIWTREQDIMHDYFRPAYFDRVTATLDPKTRLPSAFHHRTTGSTVR
TYYDRKPWPEGKLDPDTLGGSVDMPYAIPNGKWEWVRQDSPVSLNWWRGVGEGHNVFVIE
SFIDELALAAGKDPIEYRLAMLQNNPRAIAVLKKVADASGWGGELSARRGRGVSLHHSFG
TFAALVMEVEVDRYGEVYLRNGTIAVDCGQPINPDGVVAQMTGGTLFGLSAALHNGVTFK
DGRVQESNFHDYRQIRMNEVPPFQVFVMPSTENPGGLGEVGTVSAPAALTNAIYAATGVR
LRSLPIDRKLLMEKGHGDEVGGASYQSKTITSHRGVAQ
>A0A0M6YM42|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia donghaensis|TrEMBL
MAVNLTVNGKDVTLDVDPDMPLLWALRDHLRLTGTKYGCGIAQCGACTVMLDGQTRRSCV
TPVGTLDGAKVETIEAIESEAAKAVQAAWVDINVPQCGYCQSGQVVTAAALLDVNPKPTD
AEIDNAMAGNVCRCATYTRIRQAIRQASDTLEA
>A0A0S4WC58|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MTADATAPRRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQPGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVRVESAPIERIYGNVVSVVDSAL
PLHPDDAGKAWARALHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
RAWNVQAAQVSVHDGRLIGPGGRQAGFGEVAAHARDIAPPASVTLKPASQYRLVGQPAPR
SDAAGKTDGSARFAIDVRPPGLLYAAVAMCPVFGGRLKAFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLEPVWDSGPHAALDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVGAATVVEAEYSVPYLAHAAMEPINCTAQVTRDHVQLWAPTQVATLAQLV
AARAAGVRREQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIERGRVTALASRSAGQSILAGELGRLFGAPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEVAAAAGLDPLAMRRDLLEAHP
RERTVLDTAARAAGWGQPLAPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGMVVNPGIVARQVESAVIFGLGAALHGQIQVKDGQVVQSNYSDYPVLGMADTPV
IETHLVPSAAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A840YTB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas xinjiangensis|TrEMBL
MTDAPASKRRFQMTRRKMILGGTLAGGALVIGYTATHPMQAAGALLSGGGPEPEESAFGS
FIRISPDGWVTVVNKQQELGQGIHAGLAAMIAEELDADWDRVRVVSARANFRAYGPQITA
GSRSVASNWNPMRNAGAAARAMFVAAAAMRWSVPRRLIDVRDGVVSHGPSGRSATFSELL
ADAGRQATPQTPVLKEAKDYRLIGTDRVRRKDSLPKSIGAQIYTQDVQLPDLLVAMVAHS
PRFGGRLARFDAVAARSVRGVVDVFAIETGVAVVAKNTFAARRGRNALTIEWDNSEAEKR
STADLVRYFHDVAAGRTDVEPSDFHSKGEDPEAAFSADAVEFSFDFPYLAHAPMETLDCV
ARVDGWDVKIISGSHLATVDQVQAARVALTVPGRVDVDVIPAGGSFGRRGIMGADYLVEC
VRIAKRMPRRPIKLIWTREDEMSSGFFRPMSHHRVLVELGKDGFPARWRHRTVSQPLLPL
GPNAQAVEGVAESPYLAAAKVIDGKIYSPTFSVPVAFWRSVGHSHNAMVMEHIVDQLARR
VGRDPAGYRRALYRRAGAKRHLAVLHELCRRAGWGTGLEAGWARGLAIHECFGTVVGQIA
EVRIDEGRPIVRRVVAVVDCGIAISPDQIAAQMEGGIGFGLSAALFGAVTIKDGVVQETN
FDSYPVIRMNEMPSIETYILPSTNRPTGMGEPGVPPIAPAIANAILALTGSPTNSLPMLQ
AGASNGGFSFPHRTVA
>A0A7W9Z952|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. MP7CTX1|TrEMBL
MKPNAGSPGSVDNKTSDRVDLSRRRAIQSGGLAIAFLWLGGGGVAQAMINARRQPGDAAA
ALADGNPPFAPNAFIRIDTDGAVRLVMSSAEMGQAIYTGSSMLLAEELGVGLDQITVEHS
PASDELYGTPMLGGQITGGSTSTRSTWQVLREAGAVARTMLISVAAEQWHVDPSTCTVDR
GVVHHTVSGRSLGFGELASAAGKLPMPDKVQLKDPKDFQLIGKPMRRVDSADKVKGATQF
GIDVRLPGMKIAVVKACPVLNGKLAKVDDKAARAIPGVVDVIRIDDAVAVVGDNFWVAKQ
GLDALDITWHPGENANLTTQQLRDALVESSLNGKSIIAREVGSRPADGTVVESQYQSPML
AHATMEPLNATVFVTSDKCEIWVGSQVPARVLSTAAKITGLSEDKVIVHNQYLGGGFGRR
LETDSPEQAVAFAKQMSYPLKVIWTREEDIRHDRVRPMYHDRISAVLDANGRPVWYGYRT
SGGTVLGRFAPGAMGKDGLDSDAIECAIEPPYDIPNVKVEWIRHDMPPGLVVGWWRGVGS
THNLFVIESFMDELAHHAGKDPLEYRRALLQKNPRTLAVLNLAAEKIGWGSSPLPSRVAR
GIALGEPFGSRVCAIVEVEVTAQGEVRLRRAVVSLDCGIGVNPSSIEAQIQGGLLFGLSA
ALYNEITIKDGAIEQGNFYDYRVLRINETPLIEVHRVENNEAPGGLGEVGTAIAAPALAN
AIFAATGVRLYKLPVDRSLLVQDAAALKSVVSAAAASDGRMAP
>A0A7U4DWK9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia sp. AS13|TrEMBL
MTISQVPLTRRRFIVGAGALVIGAYLPSTGALARTTPVTAPESNAFEANAFVQIGEDGIV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDTSVYKNLSFGFQGTGGSSSV
ANAYDQMRRMGAMARALLVQAAAQSWKTSAQEITVQAGKISHAASGREAGFGEFAALAAK
LPPPDPAGLTLKDPANFTLIGKVSGLHRVDSLAKTNGSAQFTQDIHEPDMLTVTLKKSPR
FGGKVASFDASRALQVPGVVDVKQTDTGVAVYAKNTWAAIQGREKLQVEWDDSQAERRNT
EQIFAEFRQVAQKTGAVATSRGKPDEVFDKADKVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDHKQLCDLFQLPPEKVQIETILAGGSFGRRIDLGNPALGPDLAADM
AAAAKAIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVGWTDTVVGHSWTLN
SAMTALVVNGVDQMMIEGASELPYTFESFRCDAHIVPGKVPTSSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPREAGVLRAVAKAANWQGAKVVDGRARGVGVAKAFDT
RVAQIAEVSIGEGGIPRVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSIALYGNITLKD
GLVEQSNFNNFRPLRIDEMPEIEVIIVPSTEKPTGVGELGVPTIGPAVGNALALLGRPRT
SLSLPLHRPNSDASVLPRKTS
>A0A375BUB9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTTLSINVNGKTREVDVDPSTPLLWALRDNLAMTGTKFGCGMAACGACTVHVNGQATRSC
VTPASAVAGARITTIEGIGTDRVGRAVMDAWLKHDVAQCGYCQNGQVMSAVGLLRSKPRP
TDADIDQAMAGNLCRCGTYQRIRAAIKDAARALA
>A0A375E7B5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAARACI
TPVGSVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLKDNPSPRP
EEIRAGITNLCRCGTYPRIERAILRAATAQHAGDPKGRASS
>A0A375BVR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLALQQATGVLLVTRAPQPAARPAPGQPGAASDYVPALPD
VFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPFGHVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAARQLGVDAAAVEAQDGVFRVRGTQASIGYGALV
AGEHVELPLAEDVLTKPVEAYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGGFVGNSLLEVDRDSVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
KPVPPLPALDDPEPALRANPATRRELLSEGELPAAGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEDGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVPNAPRTLEMGDRTAVPPYGYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAAGADPVDFRLRHLPDARAADLLRAVAEAAGWQRGAAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIDVVLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMASTTSTKG
>A0A3S4JM36|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia plymuthica|TrEMBL
MTISQVPLTRRRFIVGAGALVIGAYLPSTGALARTTPATAPESNAFEANAFVQIGEDGIV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDTSVYKNLSFGFQGTGGSSSV
ANAYDQMRRMGAMARALLVQAAAQSWKTSAQEITVQAGKISHAASGREAGFGEFAALAAK
LPPPDPAGLTLKDPANFTLIGKVSGLHRVDSLAKTNGSAQFTQDIHEPDMLTVTLKKSPR
FGGKVASFDASRALQVPGVVDVKQTDTGVAVYAKNTWAAIQGREKLQVEWDDSQAERRNT
EQIFAEFRQVAQKTGVVATSRGKSDEVFDKADKVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDHKQLCDLFQLPPEKVQIETILAGGSFGRRIDLGNPALGPDLAADM
AAAAKAIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVGWTDTVVGHSWTLN
SAMTALVVNGVDQMMIEGASELPYTFESFRCDAHIVPGKVPTSSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPREAGVLRAVAKAANWQGAKVVDGRARGVGVAKAFDT
RVAQIAEVSIGEGGIPRVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSIALYGNITLKD
GLVEQSNFNNFRPLRIDEMPEIEVIIVPSTEKPTGVGELGVPTIGPAVGNALALLGRPRT
SLSLPLHRPNSDASV
>A0A1R3VCH3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium prunaredense|TrEMBL
MTAFTINGRAVDLAAEPDTPLLWVIREHLKLTGTKFGCGIAQCGACTVHVDGEPTRSCIT
LLQDVAGMEVTTIEGLSPDAGHPLQQAWITEQVPQCGYCQSGQIMQAAALLKSNPNPTRE
QIVEHMDGNICRCGTYVRIISAIQRAAREA
>A0A1L5NSG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium gallicum|TrEMBL
MSYAISVNGQIHHVEDDGQTPLLWVLRDTLKLTGTKYGCGAAQCGACTVHVDGEPMRSCT
LTLELAASSQITTIEAVEGADVKAIRDAWVAHDVPQCGFCQSGQVMSAVALLRTIEKPTN
RDIDLAMSGNLCRCATYNRIRAAIHDAASKLGTRT
>A0A841HHT9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Povalibacter uvarum|TrEMBL
MAGRSDRTAVTTDDESVATITSPSRRSFLQYSLAGSATLVMGSTFVGDEAAASISLPELG
EILDFPDVIALAEAPYASNLLLEITTGNRVRFELPRLDKGQGIATAFAMLIADELDSDYE
RTDVTLSDRRADRPFSITGNSAAIRALWDPVRSLCAHARARLVTAAALRWSVRASSLRTS
QSSVIATDGRIATYGELSAEAARVAIPLIPVTPKPVSQYKIVGTKRARKNARAIVTGTEK
YTLDTSVAGAMPTVVARAPDIGGSVLSWNGAVAASMPGVIGIVPIPNGIAVTAQTFKQAF
DARDALQISWRPGPVRGQSDAGMRNTLRQINTPLTPVLPLVGSLSATFEFPYLAHAMMEV
MSAVADVRDQSAEIWYASQSPNFVAAQVAQSTGIPASKVKIHIPFAGGSFGRRLFGEAAV
EAALVSKALRMPVKLMWTRNDDMRHGRFRPLSRCDIRASWLAGATLSYEHHIAAARNDFR
HGLGDALTAAGVNVVPDLFNQVGFITMISLPYRFGNTSSKLVEKELGVPTASWRSVYSGV
MTVANEIFIDEMARIRRYDEVDFRLRHLDSAAAERCLRYVAAAGAWGRTMPRGQAQGVAV
HAEYRSAVAYLVEIDTTGPEPRLLKAYCAVDVGVPVNVSGLQAQMQGSLIDGWSVMFRAG
NHVDDGRIREGSFGDFHWARMRHAPVTTQVHVFPAEGSNAEPGGAGELGITAAAAACVNA
YARATKTQPRRFPVQEYD
>A0A853D580|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Muricauda sp. ARW1Y1|TrEMBL
MTLVKTKIGRRAFIRNAGLASGGLVIGFNWLASCKMTPEQVNSLPKEWFELNGFLKVGDN
GLVTIMSPNPEIGQNVKTSMPMIVAEELDVAWKDVIVEQAPLNTAIFTRQLAGGSQSIRQ
GWEGLRMAGATARYMLKEAAAQAWGVPANEITTKDGTLTHEASGKSAGYGEMASAATSIE
VPDEVELKDNNSFSIIGTDKKNVDGKAIVTGKPLFGLDVYKEGMLTAMIVHPPAFGMKYK
GMNADAVKTMPGIKDVFHFEVYPEGMEKQWSDQGGIPELVAIVGNSTWECMQAKKALNVE
WEQDSMAESTSYHEESLAQLLEKPTETPARKDGDVDAAFKKAAKIVESTYSAPYLAHNTM
EPMNFFAHVTPEKAELLGPIQTPEFAEKSLAARLGMPLEKIDIMMTRMGGGFGRRLYGPF
VIEAAVISQKMNAPIKLVYTREDDMTQGTYRPSYKVKYRAGLDENGNLIAWHVRGAGTND
DLVFENRFPAGAVDNYLAEKHSLSTNVTTGAWRAPRSNFIAGAEQAFMDEVAEAAGKDPL
EFRLELFDRAINNPVGDPENNDYDPERYAGVLKLVKEKANWGTDTGKARGVAAYYCHNSY
VAQVLELEDGGDMPRVDKITCAVDCGIVINPLAAKNQIEGGMIDGIGHATYSALSFENGR
PEQSNFDTYRLIRHSEAPKNIEVHFVDNGIDPTGLGEPSLPPAIGALSNALYQATGRRFY
KQPFINDKPPLVG
>A0A6J4J3Z5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Acetobacteraceae bacterium|TrEMBL
MLEFTLNGAAVALDVPGEVPGDASLLHVLRGPLGLSGPRFGCGAEQCGCCMVLVDGEPAC
SCALAASAVGGRAVVTVEGLGTAAAPHPLQAAFLAEQAGQCGWCLPGILVSAAALLAANP
DPDDGAIRRALDPHLCRCGSHNRIVRAVERAARAMRGGGAA
>A0A1V0RJ42|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus|TrEMBL
MQLTVNGTAHSLEDLEPEMPLLWALRDVLGLTGPKYGCGIAQCGACTVHIDGVATRSCQV
AVGDVWGPVTTIEGLGTPDVPHPVQAAWIAHQVAQCGYCQSGQIMQAASLLSETPDPTDT
EIDDALSGNLCRCGTYPRIREAVKTAARTLKGA
>A0A090WMD0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algibacter lectus|TrEMBL
MAPSKKMTFSRRSFLKSSALASGGMIIGFNLFNACKPEAKLPVDLSALNYNDFNAFIKIS
EEGKVTIFSPNPEIGQGVKTSMPMIIAEELDVLWEDVYVVQAPLDTKNYTRQVAGGSQSI
RFGWEPLRQTGATAKQMLVNAAAARWGGVDASECSAKNGVITNVKGDKLGYGDVVLEAAG
LEVPEDVTLKDPKDFTIIGQGKGNVDIDKIITGKPLYGLDYKEEGMLYATVLRPPAFGQI
LESFDDSEARALPGVVDVITIGEKVRAYNDSGKIAGRCQ
>B2TF38|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)|TrEMBL
MTGPDFSVDRRSAPPSRQQLYDAQSVLIVTRAPQAPVKPAIGQPGSRSSFVPTEADMFLV
VRDDGSVVAFNGHVDLGTGIGTALAQIVAEELDVPLTRVSIVLGHTREAPNQGPTIASAT
IQISAVPLRHAAAQARQFLLAEAAARFNVSVEQLDVRDGVVYRRDGGAAAKGIGYGELIS
GKRVELQLATDAPLKSPDTYKIVGKSTPRVDIPAKATGELSFVHDVRVPGMLHGRVVRPP
YAGVAQGDFMGNSLLQVDEDSVSELPGIVKVVVIRDFVGIVAEREEVAQQAAKRLRVQWK
EVEGLPSLETSEEVEAALRANPAKRRDLVIEGDVDAALAQDSARTLERTYVWPFQMHASI
GPSCAVADYREGALKVWSGTQNPHSLRADLALLMSMDEAHIEIVRMEAAGCYGRNCADDV
AADAALLSRATGSPVRVQLSREDEHAWEPKGAAQLMDVRGALNAEGELAAYDFATRYPSN
DAPTLALLLTGTISAQPQVFEMGDRTAVPPYDYRSMRIVCDDTPPIVRASWLRGVSALPN
TFAHESFIDELAVEAGIDPVEFRLKHLTDPRAIELVKAVAEKAGWEARSAERNAELKDEE
GDIARGRGIAYARYVHSKFPGFGAAWSAWVADVEVNRKSGDLAVTRVVVGQDTGTMVNPD
GVRHQIHGNVIQTTSRALKERVTFGENAVTSQEWGAYPILTFREVPVIDVVMMPRHGEPP
MGAGESASLPGAAAIANALFDATGVRFRRPPFTPETIRAALADAQAEDKAARRKKRWRFG
FLGALAAGAAGWLGALSLAPHAIAPITPPLASAFAPELVARGKLLASLGNCAVCHTAHNG
VPNAGGKPLDTPFGTVYSTNITPDGQTGIGNWSLEAFVRAMRQGISRDGHRLYPAFPYTS
FQNTSDDDLKALYAYLMAQTPVRSHPPETKLAYPFSVRPLMSAWNALFLGRTTFTASTTQ
TAQWNRGAYLVNGLGHCGACHTPRNAFGAEKTGAAFMGGGMADGWEAPALSALSTAPVPW
SEDELFSYLRNGHAPLHGVAAGPMAPVVGDLAALPDSDIRAMATYLASLNPLEPNADPVA
MARQYEQASAISGAPAGLGARLFDGACAACHHTGGGPQLFGAHPSLALNTNLHSATPDNL
IRVILDGIGSPARPELGTMPAYRDSFNDVQVAELVSYLRQQFAGGKPAWQDVAARVARIR
ATPRRAD
>A0A1D8I879|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter ruhlandii|TrEMBL
MTRLQVNGQTKEVSVPDDMPLLWVLRDELGMTGTKFGCGMALCGACTTHLDGQPTRACVT
PVSAAAGRAIGTIEGMEADPVGRSVQRAWVENNVAQCGYCQAGQIMTAVGLLKTTPAPTE
QQIDEAMSGNICRCGTYPRIRAAIKQAAAQLAQGGK
>A0A1N7RX40|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ribeironis|TrEMBL
MSQGLLDAQNGAQSSKGRAGGVSRRAFLTFGVTVGAAAGGGLLLGFSMPAASQDQKAGKS
VIGGDAIEAPQGGVFAPNAFIQIDTAGKVTLVIPKVEMGQGVYTSIPMLIAEELEVPLDA
VTVDHAPPNEKLFKDPLLGGQLTGGSTSIRFAWEPMRRAGATARILLINAAAQQWQVDPA
SCHAQAGQVIHAASNRSIGYGQLAQAAATLPAPQNVPLKDAKDFRLIGTPVKRLDSPEKV
DGTALFGLDVRVPGMVYAAIANCPVFGGTLASVDDTNAKKIPGVRQVVKLDNAVAVIGEH
TWAAKRGVQALDIKWNEGAGANLSMKQIVDDLAHASQRNGAVARKDGDVGKAFSNAKSRV
DAVYQQPFLAHATMEPVNCTVHVRADGCEIWLGSQVPTRVVDAAVAVTGLPADKIVVHNH
LIGGGFGRRLEFDMVTQAVKIGKQVSTPVKVLWTREEDIQHDMYRPYYYDKISAGLDANG
KPIAWQHRIVGSSILARFAPPAFRNGLDPDAVEVAADLPYDFPNQLIDYVRQEPHAIPTA
FWRGVGPTRGTFVVESFIDELAAQAKIDPVKYRQDLLGKTPRALNVLNEAAQAAGWGSAL
PKRQGRGVSVMHAFGSFFAIVVDVAVDQGEVAVKRVVCAVDCGMAVNPNTIEAQVQGGII
FGITAALYGEITIKDGRVEQNNFTDYRMLRIDQTPPIDVHLVKSSEAPGGIGEPGTAALA
PALTNAIYAATGKRLRQLPVGRQLQTA
>A0A137S805|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter excellens LAMA 842|TrEMBL
MAFSLTINGQRHTVDVDSDTPLLWVIRDEVGLKGTKFGCGAGLCGACTVHVNGQPARSCS
TPVASVDGASVTTIEGLSEDGQLHPLQQAWIDQGVPQCGYCQSGQIMTAAHLLNNNPSPS
RQDIVTAMTGNLCRCGTYSRIVAAVEAVAGSVGHYQPAGEDA
>A0A1N7SAG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia piptadeniae|TrEMBL
MSTTLVLNGKSTTLDADPNMPLLWAIREVAGLHGTKFGCGMAQCGACTVHLEGQPIRSCI
TPLSAVEGRHVTTIEGLQGKPAKAVQAAWVKLQVPQCGYCQSGQIMSAAALLAQNPKPTD
ADIDAAMSGNICRCATYTRIRAAIHDAAGAVRNQVASDESEAPILAERVGAHGTTASAEA
LTLVDRSVVHGTRVSAEALTLVDRG
>A0A1P8UMR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger abyssi|TrEMBL
MQLTVNGTTRDVDVDADTPLLWVIREELGLTGTKYGCGVAQCGACTVLVDGIPTRSCVTP
ADSVTGTEISTIEAVRETEVGKRVVEAWVENQVPQCGYCQSGQVLTAAALLTETRQPSDD
DIEGAMINLCRCGTYNKIRAAVRGAAEG
>A0A7W6CCX1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MAITLSINGAARSVDAPDDMPLLWVLRDELNMVGTKFGCGAGLCGACTVHMDGAAVRSCQ
TPLGAVGAAKITTIEGVGETPIGAAVQKAWVAVDAPQCGYCQAGQIMSASALLAATPKPT
RTQITQGMSGNLCRCASYHRIMDAIELAAKETSHAG
>A0A6J5GSI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MELIVNGVHHNVDADANMPLLWAVRDLLGLHGTKFGCGVGACGACTVHLDGVAVRSCVTA
LADVQGKPVTTIEGLGQGGDHPVQRAWKAANVPQCGYCQPGQIMQAASLLKQTPKPSDEQ
IVEAMSGNVCRCGTYQRIKAAIKAAASEA
>A0A841A2U9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodesianum|TrEMBL
MVSLTINGHQHTVDADPDTPLLFVLRDALGLTGTKYGCGIGQCGACTVLLDGQATRSCQV
PVESVGAQAVTTIEAIEADPVGARVVAAWIGIEVPQCGYCQSGQVMAATGLLKETPKPSE
DEIAAAMTNLCRCGTYNAIAAAVRQAAA
>A0A841A2C2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodesianum|TrEMBL
MNDLTPLHRLGIGARHPVEPVQNLSRRGFLGIAAGALLLGIDLPGEAAAQTRAEGPAAVA
PKPGTRVAAFLEIRPDSSVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFAVECAPPGP
DYAVVNGLRMTGGSFSTRSSFEAMRRLGATARDMLMRAAAARLAVPQDSLTTEDGRVIHA
ASGRSLGYGEVAEAALALPPRDDVALKDPKAFRWIGRPVARLDMRDKATGRATYAIDIRV
EDMLHAAVQHAPQLGTEPQTIANEAEVQGMPGVHSVHRLPGAVAVVADSWWRARKGAEAL
QVAWTDPAPEGTATVSKTFSSSAMLAALKGSTEPGIPAEQEGDPAAAFAGAARVIEAEYD
APYLAHAQLEPPSAVARFTADGSLDLWLPNQMPELFQQIAAKTAGLTPERVRIHSPMLGG
FFGRHFAYGPANPFPQAILLARATGRPVRVLWSREEEFGMDAVRPLSFARFKAALGADGM
PVALQTTAVGEGPIGRWFGALFKSPVDSSVVEGLDKKPYAIPNRRLDYVKVPHPVTIAFW
RSVGHSMNDYFYESFLDEIAAAGGRDPFDLRMALLKDSPRHRTLLRAVADLAGGWRRGPF
PAEDGTRRARGISMASPFGSETATIAEVSLKDGEARVHDLWIAIDPGSVVNPAIVKRQVE
SAAALGLSSTLLEQVVYENGQRQAKNFDAYPILDRERMPRVHVTIVESGAPMGGIGEPGL
PGVPPAVVNAVAALTGQRVRSLPLAKTHLSGV
>G8TEH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Niastella koreensis (strain DSM 17620 / KACC 11465 / NBRC 106392 / GR20-10)|TrEMBL
MSTHTFSRRRFLQTSGTLTGGLLVLFFIPASAKRLGEKMAGTEDVLFAPNAYLSITPDNN
IRIMLAHVEMGQGVWTTLPMLMAEELDCDWNKIIVEHAPPGQPFVHTAYGIQITGGSSST
WSEFDRYRNAGATARALLLTAAANKFNVPVTSLRTEKGYVIAGDKRVPYGELAEAASKLP
PPASVQLKDKKDWQYLGKPMRRLDAKAKANGEAKFGLDVIFPDMLVAVVAHSPVFGGTVK
TFDATAAKAIKGVRDVVKVPTGVAVIADHFWAAKKGRDVLKIDWDPGAGNSFGTTTQFEE
YRKLAATKGIPAGKAGRVDEAMGKATKKITAEYVFPYLAHAPMEPLNCTVKITGNSAEIW
TGTQMPGLDQMAAAKILGFEPSQVTLHVQFLGGGFGRRATPTADFVSEAVQVAKASGKFI
KLVWSREDDIRGGYYRPAFLHQVNIGVGNDGMPAAWQHSIVGQSIVAGTPFQGMIKDGID
ATSVEGVNDSPYLESIPNYAFELHSPKTPVTVLWWRSVGHTHTAFVMETLIDELAAAAGK
DPVVYRRSLLKSKRHLGVLELAAEKAGWNNPLPAGQFRGIAVHESFGSFVAQVAEISIDQ
GQLKVHRVVCAVDCGTAINPDGVRAQMESGIIFGLTAVLYGEITLENGKVQQRNFHDYKM
LRMNEAPLMEVHILESGEKMGGAGEPGTPPIAPAVANAIFAATGKRVRQLPLKPSDLKTM
>A0A840IPZ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Amycolatopsis jiangsuensis|TrEMBL
MAQPHHASRPDEAPRSMDRRRFLGFVLAAPTLAVAAQLGDAVFAPQEASAAIPTLPLPEE
IFDLGDLQNLAAAPTAGLVAVGIGEDGRATFAVPRCEVGQGMTTAVAMMIAEELDLPLSQ
VDVTLADARPELLMNQLTGGSNSMRSIYLPVRTASAVARSRLMAAAAAKWGVSASDLSTS
GGVVRHRSGKTAGYGELAKAAASAKTLSVTTELKKRADFKVLGTPQNRIDALAAVTGRKE
YTLDLKVPGALPTMVARPPTIGGTPRSVDNAAEVLAMPGVTDVAAISHGVAVRAETFSLC
IDAIRALKVTWAPGPVAGESDETVLKKLKAAQLPLAVPGALTKSVDAEFTFAFASNSPLE
TGSAIADVRDGRAEIWSCLKVPIVAQGDIAKAIGLPVNAVTVHVTQGGGSFGRHLFHDAA
LEAAEASKNMGKPVKLMWSRTDDFRAGRTHPMCVTRVRATHTLGNVVSFEQRHTSVQTEF
SHGLGEMITNFAAKLPVAGNLSFAETIFELTQSSPYNFGVTTQLLNEIPLQFSTGSMRNI
YSPNVVTAEELVVDQLAKEMGKDPLTFRREFLRDAKLRAVLDKAAEAGNWGRELPDGVAQ
GIALHSEYRGAVAVLAEIDCRPETVNRKIREAVTGPRVTKATVVVDPGFAINPRGLEAQM
IGGLNDGIAMCLTSSLHMKDGIPLEGSWDNYFYTREWNTPLETKVVILPNSSDTPCGAGE
LAVAPAFAAVACAYARATGSMPTSFPINHGTLSFEPLPLEPSTPASPTDGLDYAY
>A0A7X0NVV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nonomuraea rubra|TrEMBL
MPEHTFRVNGEQVTVNVADDVRLLWVLRDVLGITGPKYGCGINVCKACTSHLNGKAVNPC
AIPVGELRPTDEVTTIEGLATGEDLHPMQQAWLDHDVAQCGYCQPGQIMAAVALVERVAA
EGRAITDEDLDGIRNICRCGTYFRIREAIRAGAANM
>F4CNT1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)|TrEMBL
MAHHRLASPPKETGLHRSVGRRKFLGYLIAAPTLVVAAELAREQVFGASEAFATIPSPPQ
TPEAYDLLDALRDAARPTANLIRVEVNKDGTVSFALPRSDNGQGIITSTQMIIAEEMDLD
VDQVQVTLADARPELLFNQITGGSSTTFTTYTPIRVAAALAKGRLLEAGAQLLAQDVRTV
TARKGLVLGSGGRSIPFSALAEKAASSTTQQVEVVLKARESFTVIGKAQNKTDARDIVTG
RKVFATDLQIPDALPTVICRAPDLNGTPGDVDNIDDVRSMPGVTDVEPVSTGVAVRARTF
GQAIDAVNALKVSWKRGTVAGENDDSVLKRVKAAELPMAVPAGVGRTIDRSFTFYFASSS
SLETNCCIADVRKDRAELWGPMKNPIAAQGDVAKICGLPVGAVTMHVTQGGGSFGRKLFY
DAALEAAECSKAFGKPVKLMWTRADDSRQGRVHPMSTGRVRAQINGDSVVSYEQRHTSVA
TQINPGLGEPVSAAAVKAPLGNLTLSESIFELTQVTPYEFGVSTRFLNEVDMRFNTTSMR
NIYSPNVATAREVMVDQIADAMGKDPYEFRRGFLKTDRLRAALDAVAKKGRWGRSMPKGT
AQGLGIHTEYKGVTAALVEIDCRPDTVNRPIREGVTGPRVTKVTFAVDVGLVINPKGLEA
QMMGGINDALALILTSSLHLDDGHFVEASWDNYFYTRQWNTPPDLDIIILDSEADEPGGA
GEFGLAATCGAIANAYARATGTVPEYFPINHKDPFPFEPKPTVPPIPESPTDGLDHTY
>F4CWJ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)|TrEMBL
MLEVALGRRRFMTYLLGVPALAVATRITFDAVAPDAAAAALPSAPSVEEMFDIGEALVVA
SAPTMPLVKLEIGEDGVARMGVPRIEMGQGITTALGMLIAEELDLRMDQVEVTCADARPE
LVLNQMTAGSSTIRAFYDPVRVLAATARARMLAAAAVEWGLPVGSLTTSGGSVTSDDGRT
ATFGELSRPAADPALQVGAVVPKAASDHKIVGTPVRRVDALDIVTGRKRFTMDLQVPGAL
PTMIRRAPTWNGTFRSLANRGAIEAMPGVLAVATIPSGVAVVAETFEQARAAVCAVDATF
SAGPVPNESNDSIMQKLKKAALPFAAPALGAVTVEASYEWPSASHAFLETECAIADVRPG
GAEIWSGFQAPIVAQQKIAVELGLPQKAVKAHVVPCGGGFGRRVFFDTAMEAALISKAVG
KPIKLMWHRTDDMRHGRCRPANVQNFRATLVAGQVATLEQRVCGVSTDYRHGLGEILTAT
ATALPEGAKQAVANDAFGQAVFLTFVASPYNFGVYDKRQTELSLGIPTSSYRSVPNQTAR
GSEEMFVDEIAERLGVDPVEFRRSTLKSERTRAVLDAVVDAGDWGRRMPTGFAQGIGVHV
ESRSHTAALIELDCRDPKNPLVTKAVMAVDVGKVINPLGLEAQMQGGLAEAISLTLKAGL
HVVDGLPLEGSYSQYHFARQKDFPSDLEIIIMPSHDGPLGGAGEVGSSAPTGAIANAYAR
ATGVRPRTFPINHPIDFDPFPPGQLPPPAFPEG
>F4CNT2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)|TrEMBL
MSTHTFTLNGERVTVDVEDDVRLLWVIRDILGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVGAISADDEVTTIEGLADGDTLHPMQEAWIDRDVPQCGYCQPGQIMAAVAKVNQCKA
EGRDVDDDAIEEIRNICRCGTYNRIREAIKAGAENM
>A0A2J7YIW5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MNTPVDTPAELLRLQRGETVNLSRRRFLAGTAVGALVLGFGLPMGSARVQAAAAAAATAE
RGTQVPAFLEIRPDGTVRLLSPFMEGGQGPFTAMAQIVGEELDVDPAHFVVDSAPPGEAY
VVMENGMRITGGSMSVRMSYPTMRRLGALARGMLLQAGAEHLGVPVDELSTTPGNVVHTT
TGRSVPYGELAGRTMDLPVPDPASVKLRDPSQFRWIGKPVRRLDAYDKSTGKAQYCIDIK
VDGMLHAAVQHAPRLGMTVGSLRNEDQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEA
IQVDWKEPAADSKVRPMPADFSSDAWREHLATVQGPSRDEENEGDIAGALANAKTQVEAS
YHNQYLNHAQLEPPSALARFNPDGSLDVWLPNQAPDMFRDDIARRTGLEPAQINLHSPLL
GGFFGRHFLYDSANPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAVVKFRAGLDAD
GMPVALEAVSATEGPTEALAGKQGEKIDPTALEGLSGKSYAIANKRIAQIYVKGPAMLGY
WRSVGNSLNDFFYESFLDELADRGGKDPFELRLHLLRDNPRLTNLLNAVADLSGGWKRGP
FTAEDGSKRARGVAMASPFGSEAAVIAEVSIDNGQVRVHDIWQAIDPGSIVNPAIIEHQV
NGAVALGLSQTLVEEAVYVDGKPRARNYDLYPILPPSRMARVHVRIIESGAKMGGIGEPP
LPAVAPAVANAVAQLTGQRVRSLPLSRHTFS
>A0A379KND8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MNTPVDNPAALLDLPPGETVNLSRRRFLTGTAVGALVLGFGLPLGVSRVQAATAAAQERG
TQVPAFLEIRQDGTVRLLCPFMEGGQGTYTAMAQIVGEELDADPATFVVDSAPPGEAYVV
MENGMRITGGSMSVRMSYPTMRRLGALARAMLLQAAAEQWSVPVSELSTEPGKVLHAASG
RSLAYGELAERAMDLPVPDPAGITLRDPSQFRWIGKPVRRVDAYDKSTGKALYTIDITLD
GMLHAAVQHAPRLGMTVGSLRNEDQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEALQ
VDWQEPGADSQVRAMPADFSSDAWREHLAAQTGPAKDDESEGDVAAALGNAKTKVEATYH
NQYLNHAQLEPPSALARFNPDGSLEVWLPNQAPDMFRDDIAKRTGLDPAQITLHSPLLGG
FFGRHFLYDSANPYPQAILLAKAVGRPVKLIWSREEEFLRDVLRPVAVVKFRAGLDADGL
PVAIEAVSATEGPTEALAGKQGEKIDPTALEGLSGKSYAIANKRIAQIYVKGPAMLGYWR
SVGNSLNDFFYESFLDELADKGGKDPFELRLHLLRDNPRLTNLLQAVGELSGGWKRGPFT
AADGSKRARGVAMASPFGSEAAVIAEVSIEDGQVKVHDIWQAIDPGSIVNPAIIEAQVNG
AVALGLSQTLVEEAVFIDGKPRARNYDLYPILPASRMARVHVRIVESGAKMGGIGEPPLP
AVAPAVANAVAQLTGQRIRSLPMSRHTFS
>G0AHI8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas fungivorans (strain Ter331)|TrEMBL
MMSLQVNGLTVEVDVAADTPLLWVLRENLKLTGSKFGCGIAACGACTVHVGGNAVRSCSY
PVSAVGQQAVTTIEAVAADPVGKAVQVAWIKHDVPQCGYCQSGQVMTAVDFLKKKRHPSE
AEVVAAMGGNLCRCGAYQRIKAAVLDASKSLA
>A0A252ES27|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella putrefaciens|TrEMBL
MAIPSSEAAKDQSLAMPSQNLTINGRSFTLNADPNMPILWALRDILGLTGTKYGCGAGLC
GACTVHLDGQPVRACLTSVSQAQGKQLTTIEGLDNQKLKNAWAEHNVPQCGYCQAGQLMS
AAALVTQHPKPSAEQIDAAMSGNLCRCGTYPRIKAALQSYAKQEG
>Q1ILY7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Koribacter versatilis (strain Ellin345)|TrEMBL
MSPVSRRDFLTTSATAAAGLVVALHLPLSSEAESAEFAPNAYVHISPEGKVTIVVARSEM
GQGVRTSLPMILAEELDCDFSQIAIEQAGASTLFGDQTTGGSASVRTCWDPMRKAGAQVR
AMLVSAASAHWKVDSSGCTTENGFVIHAASNRKASYGSLVGAAAKLPVPAEPKLKDAKDF
KLIGKPKQRLDTKSKTNGSAIFGIDFKVPGMKYAVLVRAPKFGATVKSVDDARAKGVAGV
THVEKIGDSAVAVVADSVWAAMSGRRALKVTWNNGENATLDSEAVSQSLREAAKKKGVAL
FNAGDVAKGAGKKVEAEFETPFLAHAPLEPGNCTAQFRGDSCELWAPTQVPQDVRDSVAA
ALNLKPEQVKVNVTLMGGGFGRRLEHDYGVEAALVSKAVNLPVKVIWTREDDMKYSTYRP
VSLHQISAHVGADGYPTELTHRIISPSISRQKGTKLDDGIDPDLKDEGAFIYPVANVLLE
YVDLDTAVPLGWMRSVYASQVAFANECFLDELAEVAGKDPLEYRLHLLREDKEIKFWDTT
WSTARMRGVLKLAAEKAGWSKPVASGRFRGIAAHACFGSYVAEVVEISRNEDQPKIERVV
VAADCGTVVNPNILEQQLHSAVVFGLTQTLYGKITVQGGAIAQANFGDYQLLRNADMPVI
ETHFVESSEAPSGIGEPPVPPMAPALCGAIYAATKKRVRALPILT
>A0A846QVU4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saonia flava|TrEMBL
MASIKTKIGRRAFIKNTSLASGGLVLGFSFLNSCKPKQVAEMAVQEMPKEWFEINGYLKI
GDNGLVTILSPNPEIGQNVRTSMPMIVADELEIDWKDVLVEQAPLNTDLYSWQVAGGSRS
ISSSWQSLRMAGATARQMLKEAAAKAWQVPVGEISAVAGKLTHEVSGNSAGYGDMASAAS
QIAVPEEVDLKERSEFSIIGTSRKNVDGRKIVTGQPLFGLDVQREGMLIATLAHPPAFGM
QLKSFDADSAKQMPGIKDVFSLKIYDDDFKRSAFHHTAFNEVIVVLGESTWQVMQAKKAL
KVEWENAPEVSVGMSMFGNEMKVNFPAGLENSTNHRLKMEELNARKGKVVRKDGNPEAAF
KNASKVIERSYSAPFLAHNTMEPMNFFANVTDDHAELLGPTQTPEWMEPAIAERLGLPIE
KVDIMMTRQGGGFGRRLYGHFMVEVAAISQKVKAPVKLVYSREDDMSQGIYRPSYYATYR
AALDADNNLTALHVKTGGIPESPLFANRFPAGALDNYLAEDWTIESNITTGAFRAPRSNF
IAGAEQSFLDEVAEAAGKDPIELRLELLKRAQENPVGERNDYDAARYAGVLELVKEKSNW
ESGNQGMNRGVSAYFCHDSYVAQVLDIAMEKDKPVVQKVTTAIDCGIVINPDAATNLAEG
GVVDGIGHAMYSAITFKDGAPEQKNFDKYRLIRHSEAPKSIETHFVQNDIDPTGLGEPPF
PPIMGALANALYKATGQRHYHQPFITEKQVLG
>A0A380WC01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Afipia felis|TrEMBL
MKVSLRVNGKSQEIDVADPSTPLLYVLRDNLELHGPRFGCGLGQCGACMVHIDGRATFSC
VLPVTAVGDREVTTLEGLMKDGKPGKLQQAFIDEEAAQCGYCISGMVMQAQALLNKKPNP
TDEEIRRHMEPNLCRCGTHAAIMRAIKRAAVA
>A0A3B0SMX4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MISLMINGSKYKVDVDPETPLLWVIRDHIGFTGTKFGCGVGECGACTVHLDGDPVRSCSL
QVGDAQKGAITTIEGLSADTSHPVQKAWIAEDVPQCGYCQSGMIMAAVALLEENPHPTDA
DIDDSITNICRCGTYPRIRKAIHRAANNKGEI
>A0A3B0XMC5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MQSIKTYTLSVNARQYELELAADIPLLWILRDHIHLTGTKYACGVGQCGACTVLLGNQPV
LSCQLTAEQVNGQKITTIEGLSEGLSGSLSGNSSGQKLHPVQQLWLDEDVSQCGYCQSGQ
IMMAASLFMQEAVPDKEQVDRVMSKVLCRCGTYSRIRKAIDRLIAAS
>A0A3B1AFZ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MVKENLSISRRGFLKLGTVSVAGMIIGLYLPSSAHSSESSEIGASGFAPNAWLAIEENNQ
VTMFLGKSEMGQGVMTALPMLIAEELEVDLAMVRVEMAISASRFGNQYTGGSQSIRENWL
PLRKAGAAARLMLIAAAAEKWGVSADTCYAEQGVVIHKNSQQRLRYGELVATAAKQPIPD
NIQLKNPENFRVIGQQVERLDISDKVSGRAKFGMDISLPGMLVATIAHSPVFGGKVKSYD
AQRALSVKGVRHVMEIDSGVVVVADGYWQAMKGVQRLQIQWYSGEYPETNTENILTQYAA
LAKVPSEIVYETGTENAGTVNDTLEIKATYQLPFQSHATMETMNCTAHVHGKGCDIWAPT
QHPQGARNAAAEYVYGKFQKTLEKIYSRFTGNIYPNIVVHKTYLGCGFGRRLEHDFVIEA
VQISKKLGLPIKLIWSRQEDMQQGYYRPGTYNKLHAVLDNKGLPLNWVHRIVGPVKGLSV
DGAANIPYTIPYHRIESAVLKTGIPIGSWRSTGGSLNTFIIESFIDEIAAVKNADPYFFR
RMLLTNKPRHEAVLTAAAKAAQWGTVLSKNHFQGIALYEARNSIVAQVVEISISNKGEIK
IHKVVCAIDCGIVVNHEIVKSQLEGGIIFGLSAAIKHEITFKNGRVVEKNFDDYPILRMY
EVPEIEVIFVAADRSPGGVGEVAVPLIAPAIANAIFSATGKRVRKLPIMPDDIM
>A0A143PU84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Luteitalea pratensis|TrEMBL
MTQPSSPATSVVRFSVNGEARTFEGDAQTPLLWVLRDTLKLTGTKYSCGIGLCGACTVHM
DGQPVRACATPVSSVAGKKIVTIEGLAPADDEHPLQTAWKKHQVPQCGYCQSGQIMQAAA
LLATRPNATEAQIETYMEPILCRCGTYQRIRAAIKDAQAAGRQG
>A0A7W6D6F0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MTMATLGKIARRTFLIGTGLVAGGLAVGYYYYRKPYPNPLEDELAEGEATFNPYVKIAPD
NTITLIAPRAEMGQGVSTTLAALVAEELDVRLDQVIVEHGPAGHAYANTTMLEEGVPFPH
FDESTVAELMRSGMAVAGKFLGLQGTGGSTSIVDGFYKMRQAGAAAREVLKLAAAKRLGA
EPGSLWTSDGIVTDPASGTTFTYGELAQEAAALAPPAEIRLREKSEWKILGKPQARIDMR
AKVTGAPIFGIDVRLPDMLFATLRMNPYRGGPIASLDDADAMKMRGVLKVVKVETGIANG
YAVIADNTWRAFQAADAVKAEWGKGTYPPDSAGIRQALEAALKEGDASYGRDDGNVETAF
ADAPRERIVEADYGVPYLAHATMEPMNATARLKDGRLDIWAPNQMPTMVRQLAAAAVGIE
TADCFVHTTYLGGGFGRRGDVDYAIYAAIVASKTEGRPVQVTWTREEDMQQDMYRPAALG
RFRARLGNDGLPVAVDMRIAAPSIIGSILPRYFPSISPIGPDKSITDGSANQPYTIANYR
VGGIKAPVSIPVGFWRSVGNSFNGFFHEGFMDEIAVAGGLDPLELRRKLMAAYPTAVNVV
DKVGAMSRWGEKLPPGTAKGFAFTLSFGTWVAQVVQVADVGGRIRIEKVWCAADPGQVMD
PAIFEAQMMSGIVYGLSSAIGEEITFADGAAEQSNFHDYTPMRIHQCPQIEVGILETAHR
MGGAGEPGTPPSIPALANAVHALTGKRIRSMPLSKEVEFL
>A0A379Z9X9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella algae|TrEMBL
MSRFTAVENFSRRDVLKLFGASGGALMLGSSALGWSPMSLAQDKLQPLNLFIAVGEDDKV
YLTCHRSEMGQGIRTGIPQVLADELEADWDKVVVVQGLADKRYGSQNTDGSRSIRKHYDR
MRQMGAMARTMLEQAAAEHWQVPVAEVSAKAHRVTHKASGRSLSYGELALAASKLPLPDE
SQLRLKPREEFTQIGQSRTIVDMDAMLDGSAIYGQDIRLEGMLYAAIARPPVLGSQAASV
DDKKARAFPGVVDIISLPAPTGAPAFQPLGGVAVLANNSWSALEGRKALAIQWQQSPNDK
HDSQAFIATLKQRVQQSGKVRRELGKPPASWPKERTLSADYTVPYLAHAMMEPPAATARV
SKDGCEIWACSQTPQSTQQNVAAALGLKEEQVKVHVTLLGGGFGRKSKPDFSVEAALLSK
RSGKPVKVFWSREDELQNGYLHAISAQHYQALLSDDGKVEALLSRTAFPSISSTFAEGVD
EPSDGELDLGFIDLPFKLPSLRCETAKAEAHTRIGWLRSVCNIQHAFGIGSFVDELALRT
GQSCPAMWRQLLGQPRVENFADQGFKYGNYGEELSRHPVDVARYLTVIDAAEKRMAQSPA
KAGEGWGFAVHRSFVSYVAVAIKVKLDGEHLQVLQAISVLDAGTVVNPDRVHSQLEGAVI
FGLSLAMLGEISFKDGKVQQSNFHDYQLLRLPQCPEIETQIIASTEVPGGVGEPGVPPVA
PALTNAIVAAGGKRYRDLPLKQYLQL
>A0A0P1IMZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cognatishimia activa|TrEMBL
MAISLKLNGNPTTVEAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHVDGEPTRSCQ
TYIEDVEGAEITTIEAMEDTKVGAAVQQAWVEMDVVQCGYCQSGQIMSAVGLLTENPKPS
VDDIHDYMHGNACRCATYQRIRAAIQRASDILEA
>A0A109D205|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. WDL1|TrEMBL
MTRLTLNGKPVDIEGVPDDAPLLWVIRENFKLPGTKFGCGLGQCGACTVHLNGKAIRSCI
TPISAAADQSVTTIEGLDAQHQHPLQRAWVAEQVPQCGYCQSGQIMQAAALLKRTPKPSD
AQIVEAMDGNLCRCGTYQRIKRAIRRASELKA
>A0A7Y9K056|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas melonis|TrEMBL
MSLTRRNLLIGGGAGVGLIVAWGLWPRGYAPNLAVAPGETAFGAWLKIGSDGHVTVAVPQ
LEHGQGVYTALPQIVADALGADWRTVGAEAAPINPLYANPLALDELFEGTLTRLPEPVEE
DVARRGGLIVTGGSTSVRMFEEPCRTAGAAARALLCKAAARRWNVAWTDCTVDAGFVTHG
TQRLRFAELAAAAAGERVPDPLPIGVQGAGKLVGQSLPRLDGPAKVDGSASFAGDIRLPD
MVHAAIRQGPVGDARLTRVDRAAADRVRGVLSVIETPRWVAAIATTGWAAQRALDALAPR
FTSDAPLPDSAGIARALDAALAAPGERIAASGDIGTLLDGAGVIAADYTAGLGVHAALET
TSATAAWRDGRLELWLPTAAPTAARAAAAAVAGLHERAVVIHPTLAGGGFGATLDPLVAE
QAALLAMRLKRPVSLVWSRGEDIAHDRYRPPARARLRARLSSNGAIAAWSMALAAPATGH
ALARRLLPGAGWAHGRGDLYAVAGALPPYRIPALRLDHHPAAIDVPTGHLRGGAHGYTAF
FTESFIDELAQVAGTEPLSYRIGMLGGDARLARCLTTVAALGGWGGGGAGSGQGIACHSF
RGSHIAVLAEAELRDGRPHVARLVAAVDCGRMINPDLVLQQIEGGLIFGLAHALGASTGL
TAGRSDVRGLAGLDLPRLADTPDIVVEFVRSDEPPGGVGELGVPAVAPAIANALHAATGI
RLRHLPLRS
>A0A7W7Q652|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinophytocola algeriensis|TrEMBL
MAEQSRSPENPTRRRFLGYLIAAPTLAVGVTWAAGGLGEDAAEAAIPSPPQPEDLFDLGD
LQNLAALPTSGLIAVQVNEDGTASFALHRCEVGQGITTTVAMLIAEELDLPVEKINVTLS
DARPELLMNQLTGGSNSVRSIYTPVRTASAIARQQLVRTAAARWGVPENEVATRDGVLSH
KSGRTATYGSLATAAASDRTIQVTVDLKAAADFRVLGKPHNRIDARDIVTGRKQFGMDLR
VPDAKPCMVRRPPTINGTVRTVHNMAEVKAMPGITDVAVVTYGVAVRGETFGQCIDALRA
LEVDWRPGTVAGESDATVLAKLKKAQLPMAVPPLGSISVDAEFTFAFASNAPLEPDNAIA
DVRSDRAEIWSTLKVPIDAQQDIARQLGLPQDKVVVHVVPGGGSFGRHLFHDVAAEAAEI
SQKMGKPVKLSWSRTDDFRQGRTHPMSVSKVRATYLLGNVLTYEQRHASTETDFSHGLGE
MITSTAAELPIAGNYSFAQTVFLLSQSVPYNFGVVTQLLNEIPLKFNTGSMRNIYSPNVV
TAMELVVDRLAAKMRKDPVAFRREFLKDKRLRAVLDKAVEVGQWGRTMPKGTAQGIALHA
EYRGAVAMLLEIDCRPEIVNRPIEHGVTGPRVTKATIVVDAGLPLNPRGLEAQMIGCLND
GIALALTSSLHIKDGIPLEGSWDDYFYTRQWNTPPEVEVVVLPPTSDTPSGAGELGVAPA
FAATACAYARATGTMPTSFPINHGTLGFEPFPLQPSTPQSPTDGLDHTF
>A0A508TZ04|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MAFTLNINGSAHEVDVDGDIPLLWVLRDVLGMTGTKFGCGQALCGACTVHVDGQPVRSCQ
TSVDSVGGSVVTTIEAIGRTPQGAALQKAWLDLEVVQCGYCQSGQIMSAAALLKDTPKPS
DADIDSAMSGNVCRCGTYQRIRAAIKQAAGV
>A0A841IYG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium subterraneum|TrEMBL
MELNVDGTIHVVDVEADMPLLWVLRDELKLKGTKYGCGAGLCGACTVHIKGEAVRSCSIS
AGDAQNAPITTINGLGTPAARHAVQAAWIEHQVAQCGYCQSGQIMTAAAFLAKTPNPTDA
EIDDAMSGNLCRCGTYPRIRAAVKAAATTLSGN
>A0A1Z5I008|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Colwellia marinimaniae|TrEMBL
MNSIKNVSRRGFLKVAGISTGAFVLGINLPLASAQTKSSSSTLSHELNFFVSIASDSMVT
LVCHRSEMGQGIRTSVPQIIAEELEADWQKVIVVQAKADAKYGSQGTAGSASIRNHFTSI
RQIGAVAREMLEQAAANIWQVQRSAVKAQQHFVVHNATGEKISFGELASHAAKLTPPDSK
TIKLKANRDFSLIGKDVKLTDLDDIVAGKAQYAQDMQLPNMLIATIVRPPVVGGKVISFD
ASEALKVTGVVDVIALKPRSIPVAINPLGGVAVLANNTWAALEGRKKLKIKWQHGDKQSH
NSSEFSKQLVKQVHQQGETVASKGNVYSHKYNDKNTLEATYTVPYIHHAPMETPAATAIV
NGNKCTIWAGTQNPQWAKSTVARELGLSEDEHDNIELNVTLMGGAFGRKSKADFIVEAVE
LAKASKRPVKVIWSREDDIQHGYYHSISANYCKAELTTNGSADHWISRNAYPPIGWLWNA
EAKVPSDSQLALGFGDIPFALNNLSIEKHAVDSFVRPGWVRSVACINNGFALGSFVDELA
VKAKLSTRQMWLNLLGIDRHVDPNKNGFNYANYDLDLTAHPIDTKRMKDLINLVSDKANI
EQALPENQGWGISFLRSFGSFVAAATKVSVVNNKVTVLEMHTAVDCGIVITPDRVKAQME
GAMVFGLSIALMNEISIKDGRVEQSNFHDYPVARIGQVPEMHVHIVESDAPPGGIGEPGV
PPIAPSITNAIYHASKVRIRDLPVNKVFSV
>A0A6H2HCP9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polaromonas vacuolata|TrEMBL
MYKTQNLSPAELFSQLPKGIQMLASSEGESSVINPALARRSFLKMATAGGFALGAFPMLA
QAATGAAAASASASKLKPIEQPSAFVSIAADGMVTVTLNRLEFGQGVQTGLPMILAEELD
ADWGKVKTQHGNADPAYIDPNFGMQITGGSSSIKNSYTQYRELGARARAMLVAAAAAQWG
VDASSLRTEQGVVIGPGGKRLTYGALAEAAMAMPVPEKVTLKDPKQFRLIGQPTLRLDAR
AKSSGQQSYGIDMNLPGMLTAVVAHPPVFGSKIKSVDDSAAKAVDGVKAVLRIALDRGGE
GVAVVANAYWAAKLGRDALKIQWDDSAREKVDSVTQLASYQALAKKTGAIKYAADVSALA
TAPKKISAEFVFPYLAHTPMEPLSCTVELTGQGADTKVQLWVGSQMPGLDSMAAAKVLGV
KPANVRIHVQMAGGGFGRRGVPGSDYVVEAAGVAKAARAAGLTGAVRTLWSREDDVRGGY
YRPMHVHRAEIGFDADGKILAWDHVIVGQSIMTGTAFEKFMVKDGVDETMVEGMKLPYDI
PMRLSAHHPVENVPVLWWRSVGSTHTAYVMETLIDEIARQSNQDPVAFRMQQFAGKHPRH
QTALQTAVDRSGYGKRKLAEGRAWGVAVHESFNTVVAYVVEASVTDGKPKLHAITAGVHC
NLAINPTSIEAQIQGAALMGLGMCLPGAAITLKDGVVEQSNFTNYTVARITDMPSVAVHI
VPSADAPTGLGEPGLPPLAPAFANAIASLTGKRLRELPFKLA
>A0A5P9GG92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF33|TrEMBL
MATTLKINGKQHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGLGSPDALATIQQAWIDHQVAQCGYCQSGQIMQAAALLAENPDPTD
ADIDEAMQGNLCRCGTYPLIRAAIHDAASKLKEA
>A0A6H2HCX9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polaromonas vacuolata|TrEMBL
MQTLNINGKDIAVNAPDSTPILWALRDTLGMTGTKFGCGVAMCGACTVHLNGAAIRSCVT
PISAAVGQKITTIEAMSLDSVGKAVEDAWVKHDVAQCGYCQSGQIMGATALLKSNKTPTD
ADIDSAMAGNICRCGTYVRIRAAIKDAASAIA
>A0A7W5NKH6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WP4_3_2|TrEMBL
MLPQTTERAGRRDFLKAGLALAGSFVLPLSLSTYVEAAPDGSAYREINDWVRVDPDGRTI
IGLSQAEVGQGVYTGLPQILADEMDADWRRVSVEFVTGRDAYRISAANEHPQQFVGASMS
VTMFHARLRVAGAQARQVFLEAGARRLGVRPTQCATKSGRVVHLQTGRSFSYGELLADAA
NLPLDPQPRLKAESARALIGQPLHKLDVPAKVNGSAVFGIDVKVPGMLAGFVKMAPTLNG
KPVAVRNRNAVRALAGVVDVVMAKDAVIVVADTYWQAKKAADTLDVQWQDAAPPADSATI
RAQNKAALMARQAAVATRIGDAPAQFDIAAKVVEADYHTPYIVHATMEPVNATVHVREHE
LEVWGPIQGQDKVRWTLGGIFKLPPEKVMVNTTFLGGSFGRKYVPDFVIHAAVASKAVGR
PVKVIRSREDDIRHGFYRPAASARMRAVLGANGYPTAMHLRVVGQSLYWSIKRDYFEKAG
GWDETMLDGLYDLGYAVPNLLVDSVSVDQHIPVSFMRSVGSTSSVFFLESFVNEMAHAAR
IDALEYRRTLLRGDPLAVRVLERTAARAGWSRKPAAGVHRGLAYCLYTGRGGAFTTYVAT
VVELRMVDGRAKLERIVCGIDCGRAVNPMLIREMVEGGIGFALTNTFKSEITFKDGAVEQ
QNFSDYPLLSLAQMPKIEVEIVESERTPQGCGEVALPPVAPAVAAALFEATGTRLRTMPL
EQELA
>A0A0M0EHC1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Komagataeibacter europaeus|TrEMBL
MTSKRISSPALRRRQVLGGAGAFVLAAILPAGRSRGAGMLVEDATASFAPNAYIRIGSDN
IVTMILPNIEMGQGIYTSSVMLMAEELGIDPQSVRIEAAPPGGGAEITGGSTSSMTEWMP
LRQAGAAARTMLQQAAAARWSCAPGACVAQDGYILGPTGQRLSYGELAADAANLPVPKDV
VLKTPAQFRLIGRPMHRLDSQVKVDGQAMFGIDVQVPGQKVGAVAACPVIGGHVGHVDTQ
AALKIRGVVAVLQIDDAVCVVADHYWAARKGLAALDVQWVEGPNATVDTQAIYRQLEGGL
SSSAILADHHGDAQQAITQAHGRYSATYRQPLLAHATMEPINCTIHVRPDGCDIWTGTQV
AERARDTTAEVIGLPKDRIRLHSQYIGGGFGRRLEHEYVTQAARFGRQVSHPLKIIWSRE
EDITRDRFRPAYLDHLEAGLDERGYITGLTHRIVGPAVVARWEPSGLGANGYDDDLSVGT
VITPYTYPAYRLEFARREPPGVITAWWRGVGGTRGLFVVEGFIDELAQRAGVDPVAYRRE
MVRNNPRALAVLERVARESGWGTPLPPNCGRGVALQFAFGSYLATVAEIEMAGPHDVRIR
RVTCAVDCGQVINPDQIAAQIEGGLIFGFSAALYNEITLEKGRVQQDNFHTWRVMRMNEA
PGRIDVHLIESTESPGGIGETGTAAAAPALANAMAAVQKRRYRFLPLLSPLNQPSGHEKE
QQG
>A0A7W5DLG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas fontilapidosi|TrEMBL
MSYANDRLLLANVSRRGLLKGLVGGSALLLAARWDLGLASETAQFGAGAMPGGWVDDPNV
FIHIDSDGGVTIINNRAEMGQGIRTSLVMVAADELGADWDRVRAQQANADQDKYGNQNTD
GSRSMRHWYDPMRRAAAAARIMLEQAAAQQWEVPVHEVRAEIHKVVHSPTGRELGFGALA
QAARDLDVPGRDALVLKSDSELRFIGKESGLINGELVSAHPKAIDGEDIVSGQAVFGADV
DLEDTLYAVVARPPVYGARVKRVDDGEALKVPGVRKTLRIEGTGQPAAFNPLGGVAVVAS
NTWAAMEGRRALEIEWDMAPAGDNADYTSDPYRESLEAAAQSPGKVIRQTGDVEAALEDA
DTRVSATYYMPHMAQSPMEPPVAIVRIRDGKAEAWAPVQNPRATREGIAQRLGIDKESVT
VHQTLLGGGFGRKSKPDFVTEAAAVAREFEGQPVKLQWSREDDIQHAYFHAVSVDHLEAG
LDADGKAIAWRHRTLSPSIASLFAPDPKHKGEFELGMGFNTMPFSIPAIRLENPPAPAHV
RIGWFRSVYNLPHAWAIQSFAHEMAMAAGRDHRDYVLELLGPDREVHNLTVGDGWNYGED
PDLYPIDTARMRRVIERATEEAGWGRETGKGRGLGLAFHHSFVSYTAIVFEVEVSDEGEL
TIHRADIAFDCGPQANPERIRSQLEGACVMGIGIALQSEVTFKDGVAQQDNFDSYLIPRM
PDAPRVVRVHLIDNPDDAMGGVGEPGLPPVAPALCNAIFAATGKRIRRLPVGDQLTG
>A0A5E6WYG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQNHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQSVTTIDNLHADPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A0B7DAM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSALLGGGLVVAFAVPGGHRFAMAAEGEGKVFAPNAFLRIGADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSTIRVEHSPASAADYGMPAFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFDVAPSTIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVVRAPVFGATV
KSFEGAQALAIPGVHKVLQVPSGVAVIAEHYWAAKLGRDALKVDWDLGPHADLSSEKLLE
SFRKLATKPGTSASQAGDAKGNFSKAAKKIDVEYSVPYLAHAPMEPLNCTVKISEQKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAGLP
VKTVWSREDDIRGGYYRSMFLHQARIGLGADGLPLSWQHVLVGQSIMTGTLLEATMVKNG
IDPTSVEGVSDSPYVKGLAHHQVDLHSPQTGINVLWLRSVGHSHTAFVMESLIDEMATAA
GKDPVEYRRTLLKEHPRHLGVLNLAVEKANWTAPLPDGHALGVAVHESFGSYVAQVAQVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLKDGAVVQSNYHD
YQVLRLNEMPVVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVYALTGQRLRELPLQLSGV
>A0A5E7BT39|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITFTVNGERRELDEASPSMPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPLAAVAGHSITTIEGLSPTQNHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
DSIRNAMSGNICRCGTYGRINKAIKRAATAPKEA
>A0A5E7R4X2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSINALSRRGFLKGSAMLGGGLVVAFAMPGAHRFAMGAENQGNVFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWTKIRVEHAPASAADYGLPGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIHTESGVVMAGEHRATYGELADEAGQL
PRPDPASIKLKDAKDWKLIGKPTQRLDTPEKITGRAKFGMDVQFDGLMTAMVARSPTFGG
SVKSFEGAEALAIPGVHKVVQVPTGIAVIADHFWAAKLGRDALKIEWNPGPNAGLDSQAL
LENFRKLATTQGLNAGQAGDTQAALAKAAKKIDVEYSVPYLAHAPMEPLNCTVSITKDKC
EIWTGTQFQTLDQMVAGKITGLKPEQVVIHTEFLGGGFGRRANPTSDFVSEAVYVAKAAG
APVKTVWAREDDIRGGYYRSAFLHHARIGLGADGLPLAWKHVMVGQSIMAGTSLEASMVK
DGIDKTSVEGVADSPYLEGLANHQIELHSPQTGISVLWLRSVGHTHTAFVMESLIDELAT
AAGKDPVEYRRTLLKDHPRHLGVLNLAVQKANWTAPLADGHALGVAVHESFGSYVAQVAE
VSQDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLSFALHSKLTLKDGQVVQSNY
HDYRVLRLNEMPVVEVHIVPSRDKPGGIGEAGVPPMAPAVANAVFALTGQRLRELPLQLA
GV
>K6YMB8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola polaris LMG 21857|TrEMBL
MSRQNEIKSVSRRDFLRYTSIAGGAFVLGAVLPSMSPAWADSSEVVGSNSLNLFVSIDDD
GTVNIVCHRSEMGQGVRTGIPQIVADELCADWSKVNVVQGLADEAYGSQNTDGSRSIRRF
YSTMREMGATARAMLEQAAGQKWGVAVSDVFAENGMIVHKPTGKTLSFAELASAAGKLTP
PQVQDLTFKTPDQFTFIGKPMTSVDLPDVLTGNTTFGQDIKLDGMLYASIERCPVVGGSV
KTFDKAAPLNVANVISVIEMPKQSMPVLFKNLNGVAVLASNTWSALQGRKVLNIEWELGD
NQNHDSDVYLAELEERIVTKGKPIRQAGDAYQAFDDASHKVAATYTLPYLVHAPMEPPAA
TAVFKDGHCEVWACTQTPQSTQQNVAGALGIDKSKVKINVTLLGGGFGRKSKPDFSVEAA
ILAQQTGKPVKVIWSREDDIQHGYYHAISAQHFQAGLDDNGKVTSWLQRTAFPSISWTFT
GTTDEPQTGELSLGFGDVPFDIENISCETHKAPAHVRIGWMRSVSNIQHGFAIGSFVDEV
AEKAGVSTAKMWLNLLGEDRIVDPKTQGFKYENYGESYDTFPIETKRLKHVLNELMLKSG
ADQPAGDNEGWGISVHRSFVSYVAVATKVKVENDKVSVLEMHSVIDAGRVVNPDRVKSQQ
EGAMIFGLSIALMGEVTIKEGAVQQSNYHDYTVLRMHQCPKIVTHIIESTAAPGGVGEPG
VPPVAASVVNAIYHASSTRIRALPVSKHYSV
>A0A8I0PI09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces stelliscabiei|TrEMBL
MPSYSFLINGKPVTVDAPADMPLLWVLRDMLNVTGPKYGCGTGVCRACTSHLDGGEIQPC
VVPVADCADREVTTIEGLADGDELHPVQQAWLDRDVAQCGFCQPGQIMAAVALLKKTRHP
TDADIDRIENVCRCGTYSRIREAIKKAAAND
>A0A7G2JQA5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia grimesii|TrEMBL
MNLPEVPLTRRRFIVGASALVIGAYLPSTGALARSSSATAPEINPHAANAFVQIDQEGIV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDTNVYKNLSFGFQGTGGSSSV
ANAYEQMRRMGAMARAMLVQAAAQSWKTSAQEITVQAGKIRHAASGREAGFGEFAVLASQ
LPPPDPATLTLKDPANFTLIGKASGLHRVDSLAKTNGTAQFTQDIHEPDMLTVTIKKPPR
FGGKVASFDASQALAVPGVVTVKLTDTGVAVYAKNTWAAIQGREKLQVEWDDSQAERRNT
EQIFTEFRQVAQKTGVVAKSHGNPDDAFDKADKVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDHKQLCDLFQLPPDKVEIETILAGGSFGRRIDLGNPTLGPDLAADM
AAAAKAIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVAWSDTIVGHSWTLN
SAMTALVVNGLDQMMVEGASEVPYSFESFRCDAHIVPGKVPTTSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPREAGVLRAVAKAANWQGAKVVDGRARGVGVAKAFDT
RVAQIAEVSIGEGGIPRVHKVWCAVDCGVAVNPDVIRAQIEGGIGYGLSMALYGNITLKD
GVIEQSNFNNFRPLRIDEMPEIEVIIVPSTEKPTGVGELGVPTIAPAVGNALALLGRPRT
SLSLPLHRPNRDASV
>A0A6J4SBE1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Sphingomonadaceae bacterium|TrEMBL
MTSFTVNGQAVRYRLPPETPLLWALRDASNLTGAKYGCGTGACGACTVHVDGRAARSCLV
PIGALEGVEVVTIEALSPGGAHPVQQAWLAEYVTQCGYCEPGMIMAAAALVEANPQPTDA
DIDGAIDHHCPCGIHPRARRAVRRAVTLRAALGPPAPRPAGSAAGQAEQGNVEP
>A0A395L1A2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ensifer sp. M14|TrEMBL
MVTFTLNGKERTFDGDPDTPLLWVIRDLEKLTGTKYGCGVAQCGACTVHLDGMPRRSCIT
PIAMIDGSDVVTIEGISGKEAEAVQTAWAGLDVPQCGYCQSGQIMSAVALLQMLPKPTDD
EIDGAMTGNLCRCATYHRIRAAIHNAANSMEG
>A0A2W0CBN1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paenibacillus illinoisensis|TrEMBL
MQNTHLRTYVKKHPDNKMAWYLLGKEYVREGQEGKANYCFQQAGEVYEAFERSKAPADIW
VDYQNKLVEMGEQKEKKQRIRKMWLTLLMLLVLALVPPADAPGFNRDAAEALASALETGD
DDWADGPISDEREVASAPITNSNVFTAARFGGNHQGETALAAAWSGAGPKVATSAVLGMQ
TSGEWALWKRNMPIKYIVQTNSSGRLTAQSYDADQCNCEPPEVSKDIKQLAQAWTAKQES
AASLSSAIHTYYKQNKTWPKNVSQLAQPFPNNILGETAPGMKDMFPAILAMQKQGKEEAG
QQAGQEQAGQSTALQADGPFADTLGGELFLQDQLEIVVDKSNHRLALISGNTIIRNYEVG
LGGGRTPEGTFVITDKVVNPNGRSDGEFGTRGMQLSDTNYAIHGTNEPDSIGLDESLGCV
RMSTGDVEELFALAPQGTPVRIGTNLLPETILVPEAKERYQHTLVPKQNNPNKTYHWLN
>A0A292Z5T3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. N23|TrEMBL
MSTHSFTLNGERVTVDVEDDVRLLWVIRDILGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVGAISDDDEVTTIEGLADGETLHPMQEAWLDRDVAQCGYCQPGQIMAAVAKVNQCRA
EGRDVDDEAIEEIRNICRCGTYNRIREAIKAGADNM
>H0T2D8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3809|TrEMBL
MTESVTTAADHLHGVLTVERSMADGSSDTFIRITASGEVAAFNGHVDLGTGIRTALGQIV
AEELDVSFARVVVVLGDTAVVPNQGATIASETIQITAVPLRKAAAQARAFLLARAAAQLG
LSENDLTIEDGLARGPDNRVLSYGELIGDDTVRLELAEDIAVKSADNYQLVGRSVPRVDL
PAKATGELTYVHDVRVPGMLHGRVIRPPYVGVDAGPFIGTSLIGVDSDSVRDVPGLIEVV
VIGDFIGVVAEREEQAILAAERLQVNWKPVPTLRDLDDIENALRANPSEARRLLDKGDVD
AAIEGAAKPMRRTYVWPYQMHGSIGPSCAVADVCDGHIRIYSGTQNPHILRADLARLIDC
PEHKIELIRLEAAGCYGRNCADDVTADALLLSRAVGRPVRVQLTREQEHVWEPKGTAQLM
DVNGGLNADGSVAAYEFATRYPSNGAPTLALLLTGRIAPEPAVFEMGDRTAIPPYDYDHM
RVTAHDMPPIVRASWIRGVSALPNTFAHESYIDELAAEAEVDPIEYRLRYLKDERARDLV
NAVAERAGWTPRPVRQEKTPENGVVHGRGFAYALYVHSKFPGYGAAWSAWIADVAVNTTT
GDVSVTRVIAGQDSGLMINPDGVRHQIEGNVIQSTSRALMEEVPFARGKVAAREWGAYPI
IAFPDVPEIDVLMLPRPDQPPLGVGESASVPSAAAIANAIYDATGVRFREPPFTPERILQ
GLRGNQVEPAKPQRLPAPDKPAATWLKPFAKRGGLVASAVAACAAAIGVATAVLPWRAIA
PITRPDPSVYSAATIARGEALAALGNCAVCHTADGGLINAGGRALDTPFGTLFSTNITPD
VETGIGAWSYPAFERAMREGVHRDGRQLYPAFPYTHFARSSDADLQALYAYLMAQAPVRQ
QAPDNALRFPFNLRPLVAGWNALFHSTQPFKPDPTKSEQWNRGFYLVESLGHCSACHSPR
NAFGAEQRDAYLAGGFADGWEAPALTSLSAAPIPWSEDELYTYLRTGQSRFHGVAAGPMA
PIVKDLATLADADIRAMATYLASFQAPSPEPAKLEALASDLEARTRVTSASSPAARLYLG
ACAVCHEVGGLPLFGARPSLALNSNLHSATPDNLIQVILHGIMKPASSDLGYMPAFKDHL
SDAQLGELVSYLRGQFAPDKPAWTGVEDAVGRIRSTTSR
>A0A558JB62|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halomonas titanicae|TrEMBL
MVEFVVNGASVSVETDSSKPLLWVLREDLELLGPKYGCGIAQCGACRVLIDGVSSFSCIT
PVGSVAGASVVTVEGLADAEGRLSIIQQAWLDEQVPQCGYCQPGFIIAVTALLESTPRPT
DTDIDETITNICRCGTYPRIRRAIHRAAAMLAER
>A0A6J5D807|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia paludis|TrEMBL
MITLTINGATHPVDVPDDMPLLWVLRDVVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRRITTIEAVGATPAGHKVQQAWRELDVVQCGYCQSGQVMAATALIASNPNPTD
ADIDAAMAGNICRCGTYNRIRAAVKQAAQGA
>A0A291SKQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces malaysiensis|TrEMBL
MVHRAAEEGREITDSDLDGIRNICRCGTYFRIRAAIEAGAEKM
>A0A1S9GQ26|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium laguerreae|TrEMBL
MLPNMDYSELPRALQHMLERGRSTPVQALPRRSFLKLTGTLGLAVGIFPHLAAAQPIDAG
EAPIALKPTEQPSAFVQIAPNGEVMVTINRLEFGQGVQTALPMILAEELDADWNLVRSQL
GTNDMAYVDPLFGMHLTGGSNTIKNSFTQYRELGARVRAMLLAAAADRWNVDVSALRTEA
GVVLAPDGRKLGYGELSEAAMALPVPQKIALKDPKDFRIIGQPTQRLDAQAKSSGQQSFG
IDFKLPGQLTAVVARPPVFGAKIASLDDSAARSVKGVKAVLRVPLDRGAEGVAVVADGYW
QASQGRNALKVEWDTSDVEKVDSEKQLAQFREIANRPGPRQFDADMAPLETAPLSLEAEF
VFPYLAHAAMEPLNCTVRLSDDRAEIWMGSQSAGLDAGVAANVLGLKPEQVVVNVQTSGG
GFGRRFSSSSDTAMEACQIAKAARSAGLNAPVRTLWSREDDMRGGYYRPTHLHRARIGFD
KEGNVLAWDHTIVGQSILTGTVFEKFQVKDGIDAATTEGMRSPYPLPMRLTVHHPVANVP
VLWWRSVGSTHTAFVMETLLDDIARATDQDPVAYRMKMFGNEHPRHRDALQLAVDKSGYG
SRTLAEGRAWGVAVHESFSSVVAYVVEASVVDGQPKLHRVTAGVHCNLAVNPRTVEAQVQ
GAAIMGLSTCLAGAEITLKDGIVEQGNFSEFTVARITDVPEFDVNIVPSADAPTGMGEPG
LPPLAPAFANAISRLTGKPVRQMPFNLA
>A0A379KQ87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MQITLPLRVNGQDVEVSAMADTPLLLVLRNDLRLNGPKYGCGLGECGACTVIIDGVAARA
CVIPLSGAANRDITTLEGLGSKAAPHPVQQAFIDEQAAQCGYCMNGMIMTAKALLDRIPD
ASDEQIRNELSGNLCRCGTHVEILRAVRRAAGRQA
>A0A181CAZ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Komagataeibacter rhaeticus|TrEMBL
MTTFRLNGRDVTVDVPGDTPLLWVIRDEVGLTGTKFGCGIGMCGACTVHIGGRATRSCVT
PVSAAEGADITTIEGIDPEGNHPVQQAWREIQVPQCGYCQSGQIMQAISLLRDYPSPTDE
EIDAVMAGSLCRCMTYVRIREAIKKAAANARGDASNG
>A0A0T5PAZ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius indicus|TrEMBL
MQLNINGTTHDVDVEPDTPLLWVIREELGLTGTKYGCGIAQCGACTVLVDGYPTRSCVTP
ADSVLDAEITTIETVEETETGRKVVAAWVENQVPQCGYCQSGQVLTATSLLNDTPNPSDD
DIAGAMVNLCRCGTYNKIRDAVRSASEA
>F9D1H5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prevotella dentalis (strain ATCC 49559 / DSM 3688 / JCM 13448 / NCTC 12043 / ES 2772)|TrEMBL
MRKNIILSGVGGQGILSIATVIGEAATAASLHLKQAEVHGMSQRGGDVQSNLRLSTEEIY
SDLIPQGQADIIIAMEPMEALRYVPFLNKDGWVITSSEPLVNIPNYPDAQRVADALRRLP
HVKALPINSMAREHHMPKSANMLLLGMAADTIGILSPEQLRAAIGRIFAAKGARVVEDNY
KAFDLGLKEER
>A0A0M1IF71|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MITLNINGETRSVDAPDDMPLLWVLRDVVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRKITTIEAVGATPAGHKVQQAWRELDVVQCGYCQSGQVMAATALIASNPNPSD
ADIDAAMAGNICRCGTYHRIRAAVKQAAKEA
>A0A144XEM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MVTLNINDRPAEIDADPSTPVLWVLRDNLGLTGTKFGCGTGDCGACTVHVDGRPARSCTL
ALSAVGNARITTSEHLADDAVGKAVLDAWLRHDVAQCGYCQSGQMMSAAGLLRGNKAPTD
ADIDRAMAGNLCRCATYQRIRAAIHDAARALA
>A0A031GN25|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium lividum|TrEMBL
MTTLTINGKQHDLALPEDTPLLWALRDELGMTGTKFGCGMALCGACTVHLDGVAIRSCVT
PVSAAAGKKITTIEAVGEDKVGLALQQAWQEHGVPQCGYCQAGQIMSATALLHKTPKPND
QQIREAMSGNICRCGTYTRIHAAIKQAATSINAKGAAK
>A0A1Y5T8R2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Oceanibacterium hippocampi|TrEMBL
MNRPFQTSRRRFLIGAAAGGGLIVGYQLLGRPAGAETFLDMTVAGEAPLNAWVRIAADGT
VTVAVPRAEMGQGVYTGLAMLVAEELEADWASVRVEQAPIDGVYGNIEILVDGLPFLPED
DGMVAGSVRWMTRKVAGMLGLQATGGSTTLRDGWEGMRHAGAAAREMLISAGAGKLGVGR
GECRAEKGRVVHPASGRSVGYGEVAEAARRVELSEEPRLKTPEQWTLIGTSPARVDIPAK
VDGSAEFGIDIRRPDMLHAAIATSPVFGGTLKSYDATKAKAMSGVVKVVEAAGGVAVIAD
NTWRARQALDAVAIEWDSGENGTVTSESIFARFARDHDEGDIDTHRDDGDVEEALAGAAT
VVEAEYRVPYLAHACMEPMNCTALVDDHRAEIWTGNQAPPLMRMAAAEAADLDGDDVTVH
TPFLGGGFGRRSETDLAFQATAIARQVPGRPVKLTWSREDDMRHDMYRPAALSRFRIGLD
AAGAPVAWSNRIVSQSVVANFMGRLMPGAPMLLKDKTTAEGAFDRPYEFANQRVEHVVSE
THVPVGFWRSVGHSLNAFCVESAMDEAAHAAKADPVAFRLALLKNHPRAARVLQTAADAA
GWGTPLPAGRGRGVALHRSFGSTVAEIAEVTVRGDGTLKVDRVVCAVDCGRAVQPDGVVA
QMESGIVYGMTAAFYGAIDIVDGAVAQGNFPDYEMLRLADMPVVETHIVESGEPLGGVGE
PGTPPIAAALANAIFAATGNRIRTLPLQKAGFAPAGVA
>A0A157Q426|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bordetella ansorpii|TrEMBL
MDSDVVLPEHSIHNVSRRRFMPAAGGLVLGLNIGQAGPREAAQTAARSPNAFVRVGKDGW
VTVLAKHLDADQGAHTGLATLVAEELDADWRQVRVEGSPAQAGAGRNGSMAESYLPIRRA
GAIARAMLVQAAAQQWRVPAGEIVIRDGIVRHPHSQRQAGIGHLAAAAAALPAPQDPVLK
APADFQLIGKEGVGRADNPAKTNGTAVFTQDFKLPGMLVAVAARAPRPGARLAGYDGQAA
RGVAGVRAVVEIPATPQHPAVVAVLAENTWAARLGRDALQARWQEGSPHEQALADPLDGY
RAAVGQPGLAVTQEGDVDAAFASAASVIEADFLQPLAVQAAMEPLSCLVRLEERRCDIWN
GEPVDPADQAAIARYLKVPVGGVTVTALHAGGNAGPRRGAQAGYLIEAVALASAARRQGL
DVPIKLTWTREDDLHGGHVRPMRLQRARLALDAAGTPLAWHVRHAGLSRQADPAQGAARV
DPPYAAPHQRVEQCSPPDGDIPAWYRSDGQAPVAFAAETLIDQAALAAGRDPVAYRAGLL
AGQPRHARALAMAAQQADWGRPLPRTIPNTRRGRGVALHAACGTVMALVAEVTVRPCGTL
KVDRVVCAVDCGVAINPGVLRAQLEGAIGAGLANCLHGLSWADSEAQQDRFHDSPVLRMD
EMPRVEMHIVPSSEAPAAGVGAVAAAAVAPAVGNALHAATAQRLHTLPFSTKMDMPAPGV
VPFMPAAPAVARQQAYGAPLPGRTASHRGADSEKRPQELETGALAA
>A0A3G7H9A0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATGALVLAASWGWQDAFAEEKKFGADGMPNGWVDDPK
VYVSIAADGSVTVLCNRSEMGQGVRTSLSMVVADELEADWALVKVRQAPGDEALFGNQDT
DGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPLAECRAQLHKVIHQPSGRELGYGAL
AAAASVLAVPARDSLRLKQPSEFRYIGKEGTRAIDGADIVNGQAIYGADVHFDGMLFATV
ARPRVYGGKVKSFDGSAALKVPGVIKVLQIDSRPLPSEFQPLGGVAVIASNTWAAIKGRE
ALKIEWDDGVNAGYDSIAYRKELEAAALKPGKVVRSTGNIDDAMSSADSSLEASYYLPHL
VQAPMEPMVAVARFQDGQCEAWAPSQAPQVTRERIAERLGIPFDKVTVNITLLGGGFGRK
SKPDFILEAAILAKEVPGKAVRVQWTREDDIHNSYFHTVSAEYLKASLNKDGMPSGWLHR
TVAPSITALFAPGMNHEAAFELGMGFTNLAYAIPNVRLENPEAAAHTRVGWYRSVSNIPH
GFAIQSFVDELAHKAGQDPLKYQLKLLGPDRRIDPRTLSEEWNYGESPERYPIDTARMRG
VLETAAKAAGWGRSLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDCGP
QINPERIRSQFEGACVMGLGNAVVGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHLVM
PPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQQAGKA
>A0A3G7H7K0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MITLKLNGQDHPLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTVHIDGSPARSCIT
PIGSVVGQNVSTIDNLHSDPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKVNPNPSD
EQIEAAMVGNICRCGTYNRIKTAIRQASSHLKEAQA
>A9DDW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hoeflea phototrophica (strain DSM 17068 / NCIMB 14078 / DFL-43)|TrEMBL
MGRLKTFTRRAFLVGSAAVVGGVAFGVYTVRTPHKNPLLADLKTGEAALTPYVRIDADGV
TLITPRADKGQGAYSVQAALIAEELDIELDQIKVDPGPPSPAYWNEALAEEAAAFMAPGD
GVTNWAAHGFLSAAMKTIGMQITGGSTTVPDGFVKLRQAGASARETLRLAAAQKTGIAAS
ELETKAGQVILPDGTSIPYSELATIAAGIEPPQDVALRDPSQWRLIGKPMQRVDIVEKST
GTLNYGIDHKIDGMVHATVVLNPAQTGPMNSFDASEALKMRGIKDVVEITGGVGIIADNT
WRAFQAARAIEFDWGPAPFPAAMEDHWQALSNSFNDDALDSRQRDDGDVEISFAETGEVI
SAEYRAPYLAHAPLEPISAIVRVDDDMVEVWTGTQIPRFIQNNISKITGIDADMVIVHVL
YMGGSFGHRLEDEVVKQATEIAMQMKGTPVKLTYSREEDMVHDFPRQIAMARMRGVVRDG
KVETYDLGITMPSVVASQMARQGLSVPGPDSQIVAGAWDQPFAIPNQRVTGYRAPELAPS
SSWRSVGASSNGFFYNAGLDELIHAAGADPMEERLRLCSNDEARKVLEAVAEMSGWDGVL
GNGRGRGVALTQSFGVHCAEVIEVTMTDAGIKIDKVYAAAEVGTVIDPVNFDNLVKGGVI
FGLGHAMNCEITYTDGIADQDNFHVFEGMRMHQCPEIEVRGLENGSRTLGIGEPPVPPAA
PALAGAIFAATGIRLREMPFSKFVDFA
>A0A3G7TNN0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis|TrEMBL
MLTLNINGKDQQLEVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PAATVANGQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPAPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A839P7E2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. RMAD-H1|TrEMBL
MNAVISISRRNFMIGVASTAGGLSLGFNVPFIKPALAEGAETPEVNAWVVIRPDDTVVIR
IARSEMGQGTLTGLAQLVAEELNCDWSKVTTEYPSPAQNLARDRVWGNFSTGGSRGIRES
HEYVRVGGAVAREMLIAAAAAEWGVPASECTARMSTVTHAASGRTATYGQLAAAAARMTP
PANVALKDPKDWTIAGKPLPRLDTADKLNGSQVYGIDLKLPDMLNAAIRACPYFGGKVKS
FDAAAVAGMPGVRTVVQVDDTAVAVVADTWWRAKTALDALPIVWDEGPNTQVTSASIATM
LEEGLGAEDAFIGNSQGDAGAALSGGGRVITATYAYPYQNHATMEPMNATVLYTPERCEV
WVPTQNGEASLAAAAEAAGLPVQQCEVHKIHLGGGFGRRGMQDYVTQAVRIARQLPGTPV
KLIWSREEDMLQGRYHPITQCKLTGTLDADGNLTALHMRISGQSILAAVMPQRMQDGMDP
ITFQGLTAESPEGHLGYTIPNLLVDHAMRNPPIPPGFWRGVNLNQNAIYLECFMDELAHA
AGMDPLAFRRKLMANHPKHLAVLNAVAERIGWDTPAPAGVHRGLAQIMGFGSYVAAAAEV
SVTDGQLRIHRIVAATDPGHVVNPAQIERQVEGSFVYGLSACIYGECTVNGGRMEQENFD
TYEVVRMAEMPEVETIILPSGGFWGGVGEPTIAVAAPAVLNAIFAATGKRIRTLPLKNHE
LA
>G0EYW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MNTPRPLTLQVNHAEHTLSVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGMPA
RACVLPVRAVVGHAVTTLEGLGTDAQPDPVQQAFIDEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVQRAAVLQRQAAEGSAS
>A0A7W7K2D6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kyeonggiensis|TrEMBL
MTRFTVNNQPVAYKMDPRTPLLWALRDASNLTGTKYGCGTGDCGACTVDVDGTARLACEV
TIGALEGTFVTTIEGLSKDRSHPVQQALIAANVPQCGYCIPGVVMAASVLLRANRNPSES
DIKEAIPNICRCGIYPRLMEAIQNAARIARGDAPEPGPAPAAQEDQPAEP
>A0A7W6JTL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas kyeonggiensis|TrEMBL
MPYQLAVNGRTHRIDEDGQTPLLWVLRDTLRLTGTKYGCGIAQCGACTIHVDGQPMRSCS
LSLETAAGSQIVTIEAVEGPEAAAVRAAWVKRDVPQCGFCQSGQIMSAVALLRSNGAPTD
DDIDRAMSGNICRCATYNRIRAAIHDAAQSSTSQAKTA
>A0A6S7CXG6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter piechaudii|TrEMBL
MFLNDTDSMLPPALQSRTEPARVDAVSRRTFLKIAGAGGFTLGAFPLRALAQDAPSAAKA
LKPNQQPSAFLHIAPDGVVTVTVNRLEFGQGVQTALPMILAEELDADWNNVRSRLGDQAP
AYADPVRGMHLTGGSASIRTSFTQYRELGARARAMLIAAAAQQWKLEPSTLRTLTGRVMA
PDGRSVGYGELARAAMAQEVPNQVTLKRPSEFKLIGRPTTRLDAKAKSSGRQDFGIDVKL
PGQLTAVVARPPVFGAGLRSVDDTAARAVPGVKAVFRIPIDLGGEAVAVIADGYWPAHQG
RQALKLEWNTESVEKVDSARQLAQYRELAVKPGPRHFDADMAPLTTAPLQIEAEFTFPYL
AHASMEPLNCTVRITNEGAEIWTGSQMPGVDADEAAKTLGLKPDQIQMNVRSSGGGFGRR
AMGHRDYVVDACRIAQEAKKAGIDAPVRMVWSREDDMRGGFYRPMHLHRARIGFDGQGRI
LAWDHVVVAQSITKGTLFEKFMVKEGIDRTAVEGMRDPYPVPMRLTVHHPDVNVPVHWWR
SVGSTHTAYVMETLLDEIARRTDKDPVAYRLELLGDKFPRQAAALRLAVEKSGYGAKQLA
AGRAWGVAMHECFGSVVAYVVEASINAGKPVLHRAVAGVHCNLAVNPRTVEAQVQGSAVM
ALAMCLPGGAITLKDGVVEQGNFGEYAVPRITDMPEFEVHVVPSAEPPTGMGEPGLPPLA
PAFANAVARLTGKPVRQLPFQLA
>A0A7W9HG20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharothrix ecbatanensis|TrEMBL
MNRRTFLGGVLVVSAPIALPASSEAAGEFAPNVFVRLDDRGRVTATVPKPDSGQGVRTMV
ALLVAEELAVGLDDVRLEQAHGDTERFGQQGVGSSFSARQLTEPIRTAAATARCLLVAAA
AKRWGVPVAECTARDGMVRHGRRALRYRSLVRDAAALDPATVPVTLTPREQWRLLGRSHA
GRVDAKAIVTGKARYGIDTRPAGALVAVILRPQWIGAVVDTVDDSAARAVPGVVAVTTLA
PVTEGQGGVAVIARSMPEALRGREALRVTWRGGTPDADSRVWLAELESALPAVPTAPGPV
AFEAVYRLPLLAHAPMEPMNSTAHLTATGLTVWTPTQDPGSLRTVLAGQLALDPANVRVE
PTLTGGAFGRRIDFDPVLEAIACSRAAGAPVSVLWTRDDDMRHDSYRPMSVHRLSAVVDA
SGVPTWRAHGIATWPLTVLPFFENPDIVKYNGDHFPYSVPGKLDVALRPAPLRTGFWRAV
YAGHFQYAEENFLSALGQRAGLDQVDLRRRLLPADSRLRRALDAAAARAGSVRPGFSRGV
ACHDDYGSVIAVIADSSEGRVRRVTAAVDVGPALHLSGVRAQVEGAVMDAVSTVSGAQIT
VRDGRVVQSSFRDYAWARIDRAPDIDVVIVPSDAPIGGLGELAYPPAAAAIASATGQTVT
GMPVGVEVG
>A0A840Z6I1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas endophytica|TrEMBL
MAEITRRRLLVSGGIGAGLVVAWAVWPRAYLPNLAAAPDERVFNAFLKIARDGKIIVAVP
QCEHGQGVFTTLPQIVADELGADWRTIGVEAAPVSPLYANPLAADWLFGDGYTGVPERGR
DEVWTREALMLTGGSTSIRRFEAPLREAGAAARVLLCQAAAQRWDADWRDCTTADGFVVQ
GDRRLRFGDLAEAAASGSLPAELPYRIGDEGRLSGQSVPRLDVPAKVDGSANFVADVRLP
DMVFASIRQAPHRDARLRSADVAAAERVPGMLHVVRNDRWIAAVANNWWAANRALNALAP
RFEGPVPPDDAAIDRALGAALEAEGYPVSQTGDVAGVFAGGRLIEAEYRVAPALHAAVEP
PAATAHWQNERLELWAATQAPSLARAAAARAIGVSERQVILHPMLSGGSFGAALEVDVVA
QAAILARELRRPVQLAWSRGEALLHDRVRAPARARMAVRLAPNGAILAWRARIAAPATGR
DLAARLLPDDPLRRLASALPPGADDYALRGAVPPYRLGASAVWHHPVALDLPTGHLRGGA
DGYNAFFTECFLDELARVAGSEPMSYRVGLLGGEPRLARCLTTVAALGGWSGGVPGSGQG
IACHRMADSRIAVLAEAGFDAGGRPRVDRLVAAVDCGRAINPDIVRQQIEGGLIFGAATT
QAAAHYHDGLASIRRYGEIGLPTLADAPEVSVELIDSTADPGGVADLGVPAVAPAIATAL
FAAEGTRWRHLPFRSA
>A0A5S9PMP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Starkeya sp. HF14-78462|TrEMBL
MHIITPDQYRVMLARFTKEVAPSRRGFLKGIAAASGALVIGVHLRPVEALAAAMTDGPMP
NAFVRIAPDSTVTVLIKHLDMGQGVTTGLATIVAEELDADWSQMRAAFAPADAQLYNNLL
FGPVQGTGGSTSVANSWEQLRKAGAAARHMLVAAAAAKWGVPAESISVEKGVLTSGNHSG
SFGEFAEAAARLDVPKDVKLKDPKDFTLIGTRLPRLDSTEKTDGKAVYALDIRRPGMLTA
VIRRPDRFGATVKSFDAAAAKKVPGVVDVVAVPAGIAVLAQNTWAAIQGRDALADIVWDE
AGAEMRGTAELLDEYKKLAATAGLPAARKGDAAKGIAGAAKTVEAEFAFPYLAHAPMEPL
NCVIEKTGDGVTIWAGSQFQTIEQAVTAGVLGLKPEQVKIETVWAGGSFGRRANPPADYV
AEAATILKATDGKAPIHLVWTREDDIKGGYYRPMFYHKVRAGLTADGKIAGWEQQIVGQS
FMAGTPFEAFAIKEGVDGTSVEGAADTNYDIGNFAVDLHTTQVKVPTLWWRSVGHTHTAH
VVEVTIDELARAAGRDPVEFRLELLKDKPRHTGVLKLLAEKANWGEKAGTGKGRGIALHE
SFNTVVGSVIDVSVVNGQIKVDRVVCAVDCGIAVNPDVIAAQVEGGVGFGLGAALHDEIT
LDKGVVEQANFDGYVPLRMSEMPKVEVHIVPSANAPTGIGEPGVPGVAPALSNAIFDATG
QRLRSLPFRLEDFKA
>A0A7G6V5W3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia|TrEMBL
MTIELDHTDAVRPSRRTFLKTAGAAAAVSLTIGFDWAGLGRRALAATAPAGDFAPNAFLR
ITPDGAVTVIAKHVEMGQGAYTGIATIVAEELDADWSSVRVESAPADAKRYANLAFGTMQ
GTGGSSAMSNSWQQLREAGGKARAMLVSAAAARWKVPAGELTTANGVVSHAKSGKTAAYG
TLVADASKLPVPDKVTLKQPADFKLIGHRIPRVDGSSKSNGTAHFTLDTTFPGMRVALLQ
RPPRFGATVKSFDATAAKAVPGVVSVVQVPGGVAVVATGFWAAKQGRDALKVDWDETKAE
KRGSDELMREYRQLAEKPGTSARKDGDADAAIAGAARKVSATYEFPYLAHAPMEPLDAVV
KLTANSCEIWAGDQFQTVDQGNAAKTAGLKPEQVKIHTLYAGGSFGRRANAWSDYVVEAV
SIAKALGADGKPVKLQWTREDDIQGGFYRPMYFHKLDAGLTADGKLVGWRHRIVGQSILA
GTPFEAFMVKNGVDATSVEGAANLPYAVPNVSVELTTTQVGLPVLWWRVVGSSHTAYAVE
AFIDEAAHAAGKDPYAFRRDLLAKEPRMRAVLELAAQKAGWDPAKPLPKGRGRGIAVAEA
FKSYVAQVAEVSVDADGKVKVERVVCAVDCGIAINPDIVAAQMEGGIGFGLGAAMHSAIT
LKDGQVEQRNFDGYHVLRMAEMPKVEVHIVPSAEAPTGVGEPGVAPVGPAVANAIFAATG
KRHYVLPFDSADSAKA
>A0A7W8YGX2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. S3M3|TrEMBL
MHQITVNGQPHSIDTDPQTPLLWVLRDIVKLTGTKFGCGIGLCGACTVHVDGRAVRSCIM
PIASVEACAITTIEGLSADGKHPLQQAWIAAQAPQCGYCQSGQIMQAATLLRDYPQPTDA
NIDAVMSGNLCRCMAYVRIRKAIKLAAADMQEAPPHA
>A0A099L5B6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Colwellia psychrerythraea|TrEMBL
MIKIILNNKPVELDVDPQMPLLYALRDELQLTGTKFGCGAGQCGACTVHVNGKAMRSCVT
PISAIAEQAITTIEGLADKQGNLGESAVQVAWREFKVPQCGYCQSGQMMSAAALLKAIPQ
PNDEQIIEHMQGNICRCGTYKRIKAAIKSAAGNTTDLAANNASPNTSPANTLPSNSLPTN
NNGVEIFDARKFTHDSKGA
>A0A1V5D7V0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Syntrophorhabdus sp. PtaU1.Bin153|TrEMBL
MISLKVNGKRYEVDVSDDTPLLWVIRENLGLTGTKYGCGMAQCGACTLHVDGRAVRSCVT
PVSAATGREIVTIEGLSSDGSHPAQRAWIEEDVPQCGYCHSGQIMSAAALLSVNPKPSDA
DIDEAMSGNICRCGTYQRIRRAIHRAAAIMAQGGRK
>A0A7W8WMP7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. MM5384-R2|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVF
PAAAVGERKIVTIEALGATPTGQKVQQAWRELDVVQCGYCQSGQVMSAASLLARNPNPSD
ADIDAAMAGNICRCGTYHRVRAAIKHAAKGA
>A0A162JZD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Frankia sp. EI5c|TrEMBL
MTEHDDPRLPVRLVVNDDEVEVRPRGHHTLLDVLRRELDLFGARPGCTAGACGSCTVLVD
GAPASSCLLPAHVVGGRPVRTVEGLAGPGELHPVQQAFIDHTAFQCSYCTPGFILTAVAL
LDREPDASRERIRAELAGNLCRCGSYVKIMDAVLDARDRMRGYHDDGTPYAGVSTAGASA
VGASAGRSGDSREPRAALA
>A0A1C3HDG7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia marcescens|TrEMBL
MSISQVPLSRRRFIVGAGALVIGAYLPSTGALARSNAPAASGATAFDANAFVQIGADGIV
TVISKHTEVGQGVYTGMATLVAEELDADWAQVRVVAAPVDTNIYKNLAFGFQGTGGSSSV
ANAYEQMRRMGAMARALLVQAAAQRWKTSAQEITVQAGKIRHAASGREAGFGEFAALAAT
LPPPDPASLTLKDPANFTLIGKTRGLHRVDSLAKTNGSAQFSQDIHEPGMLTVTIKKPPR
FGGKVATFDAERALAVPGVVAVKQIATGVAVYANNTWAAIQGRDRLRVTWDDAQAERRNT
EEIYAEFRQVAQKTGVVAKSLGKPDEVFDKADKVIEAEYTFPYVAHAPMEPLDGYLFWDG
ESVKARYGCQIQTLDHKQLCDLFELPPDKVQIETILAGGSFGRRIDLGNPTLGPDLAADM
AAAAKGIGPGHGVKVVWTREDDIRNGWYRPMILHRLRGAIRGGKVVGWTDTVVGHSWTRH
SAMDALVVNGLDQMMVEGASEVSYTFEAFRCDAHIVPGRVPTTSLRSVASTHTGHAVESF
IDQLLQETGQDPVEGRLALMGDAPRAAGVLRAVAKAADWQGAKVVDGRARGVGVAKAFDT
YVAQVAEVSIGEGGIPKVHKVWCAVDCGVAVNPDVIHAQIEGGIGYGLSLALYGNITLKD
GVVEQSNFNNFRPLRIDEMPEIEVIIVPSSEKPTGVGELGVPTIAPAIGNALALLGRPRT
SLSLPLHNPTANPASDKERT
>A0A238K1W8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Maliponia aquimaris|TrEMBL
MAVTLNVNGTAQEVDLPPEVPLLWALRDALNLTGTKFGCGVAACGACTVHIDGEAVFACQ
VPIGEVWGDITTIEGLGTPDALHRLQQAWIDHQVAQCGYCQSGQIMQAAALLAATPNPTD
DQIDAAMSGNLCRCGTYPRIRAAIKSAAGEA
>A0A654CW29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia sp. 8Y|TrEMBL
MTTLSINGQSHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAMRSCVL
PVAAIGDKKITTIEAVGATAAGKKVQDAWNQLDVVQCGYCQSGQVMSAAALIAAVPNPTD
ADIDAAMTGNICRCGTYNRIRAAIKQAAKGA
>Q1IBG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas entomophila (strain L48)|TrEMBL
MNARIDSSDDLLRLRNGETVNLSRRRFLAGTAIGALVLGFGLPLGSARAQAAAATTERGT
QVPAFLEIRPDGSVHLLSPFMEGGQGINTAMAQIIGEELDADPATFVVDSAPPGEAYVVM
ENGWRITGGSMSVRMSYPTMRRLGALARAMLLQSGAAQWGVPVSELTTKPGKVVHTASGR
ELGYGELAAKAMDLPVPDPASVTLRDPGQFRWIGKPVPRLDAQDKSTGKAIYSIDIKVDG
MLHAAVQHAPRLGMTVGSLRNEDQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEALQV
DWQAPGADSQVRPMPADFSSDGWRDHLAAQTGPSRDEENEGDVAAALAGAKTTVEATYHN
QFLNHAQLEPPSATARFNPDGSLEVWLPNQAQDMFRDDIAKRTGLDPARITLHSPLLGGF
FGRHFLYDSANPYPQAIALAKAVGRPVKLIWSREEEFLRDAMRPMAVVKFRAGLDDKGLP
VAIEAISATEGPTEAIAGKQGDKVDPTALEGLSGKAYAIANKRIAQIYVKGPAMLGYWRS
VGNSLNDFFYESFLDELADKGGHDPFELRLHLLRENPRLTTLLQAVGELSGGWKRGPFTA
EDGSRRARGVAMASPFGSEAAVIAEVSLEGGQVKVHDIWQAIDPGSIVNPAIIEAQVNGA
VSLGLSQVLLEEAVWLNGMPRARNYDLYPVLPPSRMARVHVRIVESGAKMGGIGEPPLPA
VAPAVANAVARLTGQRVRSMPLSRHTFS
>A0A5P9CU06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Labrenzia sp. THAF82|TrEMBL
MSVTLKINGETRTLDADPESPLLWALRDELGMTGTKFGCGIAACGACTVHWDGVAIRSCQ
TLVGDLDGAEITTIEGINTKAAEAVQTAWNELDVPQCGYCQSGQIMAATALLAETPKPTD
EDIDAAMDGNVCRCATYARIRKAIHLASDKMEG
>A0A3G7C1X4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. piscium|TrEMBL
MLTFNINGKDQQLEVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PAAAVANGQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPSPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>B2AIA0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MDGIARLSRREFLRGSLGLMTLAVTSGGLVTVARAADPAPKKFGADSMPGGTVDDPLAFV
SIGADGTVTIVAHRAEMGTGVRTSLPMMVADEMEARWERVKVVQAEADETRYGNQNVDGS
RSVRHFLMPMRRVGAAARHMLEAAAASRWSVPVSEVRAVQHEVVHQPSGRRLGFGELAAD
AARQPVPKGDALRLKPRTGFRYIGKNAVRPVDQEAIGTGRATYGMDLRLPGMVYAVVARP
PVVGGKLRRVDSRKALALPGVLKVVEIPAFQGAPAFQPLGGVAVVARNTWAAMQGRAALE
IEWDDGPNGGYESVAYRRTLEAASRAPGKAVRNQGDAQRAWDQAPPAERLAADYYVPHLA
HASMEPPVATVRIRGGSAEVWTSIQNPVAAQAAVAKRLELQPGNVRVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPEGTPVKLVWTRDDDIRHDYLHTVSAERLEAVVDRQGQVKSWLHR
SAAPTIASLFTEGAKGQQMFESAMSAINMPYRIDNVRVETAEVPAHARIGWFRSVANIPH
AFAAQCFIAELAHRAGKDHREFALDLIGPARKIDPGTLADTWNYTESPERYPYDTGRLRG
VIEAATRGAGWGRKLPKGHGLGLAFCYSFMSYTATVVEVAVDTKGEVRVVSVDMAMDCGP
QIHPDRIRAQMEGGAIMGLSLALASEITFDKGRVLQSNFHDYEVLRHHASPRVIRTHLVN
DNHDLPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVA
>A0A165PIN3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. Ad26|TrEMBL
MIRFQLNGNSVTTGVNEDAPLLYVLRNDFSLNGPKFGCGASACGACTVLVNGQAVRSCIT
PVSLVADTEVVSLEDQTPDSVLSVLQQAFLVEQAAQCGYCSNGMILTATELLSNNPAASD
AEIREGMDGILCRCGAQARVLKAIKRAQVQI
>D3P4L3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum sp. (strain B510)|TrEMBL
MTILHINGRTHQVAVEDDTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGTATRSCQV
PVDSVGGADIRTIDAIEEDPVGRKVVEAWVATQVPQCGYCQSGQVMAATALLKQTPHPTD
GDIADAMTNLCRCGTYNRVAAAIRQAAG
>A0A7W9AGA8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium boeckii|TrEMBL
MAQELNVNGRNRKLDGDGDMPLLWALRDLLHLTGAKYGCGIGLCGACTVHVNGEAVRACM
MQLGDVPPGSRITTIEGLGTPDKPHPLQTAWIVEQVPQCGFCQTGMIMAAAALLKETPKP
SESEIGGAISNICRCGTYSRVVKAIQRAAGQLSKA
>A0A238JVZ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actibacterium lipolyticum|TrEMBL
MTVQTTRRGFLAGGLAAGAALVVGFTPKGALAAGHGGAEINPFVKVDADGTLTVVLKHFE
MGQGTTTGLTTLVAEEMDADWDAVAIEFAPADDSKYANLFFGGQGTGGSTAIANSFMQYR
QAGAAARAVLVAAAAKQWGVAESDITLEKGMLKSGDKTGHYGEFAAAAAEMTPPAEPVLK
DASAFNLIGDARLPRKDSAAKTDGTATFAIDVRLPDMVYAVLLRSPKFGGKLTSFDASAA
ADIQGFVDARAIANGAGVAVYGTSTWAAISARDAITAEWDFSAAETRSTPDIEAEHIALL
DTPTYEARPGATLADSTAALEGAAQVVEADFLLPHLAHAPMEPLNCTIEATENGVRVHDG
CQFPTLTRPFVAGTLGLDPSQVEIVTVYAGGSFGRRANTVSDYHVEAALVFDALGRERPV
KLVWTREDDLAGGFYRPMAAHRAKIGIDGDGNITGWDHRVAAQPIFKGTPFEAVIVHDGV
DHGSVEGIADTPYNIPAFSVGLSDWTSPMPVLWWRSVGHSHTAFVKESLIDMAATAAGRD
PIEFRLSLLGDDTNADHKRLRGVLELVAEKSGWGGDLPEGRGRGVAVHKSFNTYVAEVIE
VSTNDGAVKIEKVTCAVDCGVAVNPDVIKAQMEGGVGYALGHVMRNQITMTDGVVDQANF
PDYEPLRIYDIGSIDVHLVPSTEAPTGVGEPGVPPAGPALANAIAAATGTRVTKLPMWEN
GIEFA
>B4ED10|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)|TrEMBL
MRFMLNGQPFDFDGDPDTPLLWVIRDSARLTGTKYGCGIGACGACTVHLDGEAARACVLP
AASVAGRAITTIEGLSHDRSHPVQRAWIEKDVPQCGYCQSGMVMATAALLARHRKPTDAQ
IDAAVTNLCRCATYQRIREAIHVAAG
>A0A839ZGY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Angulomicrobium tetraedrale|TrEMBL
MRHDPEDAYRGRPALTRRALLRGGAAILGGLVIGIELPVRRARADEPAAAGAPLNAFVHV
PAEGPVRLIMPAVEMGQGVYTSQAMCLGEELDIGLDQITAIHAPADQAKYGNPLFVVQAT
GGSTTTMAWTEPLRQAGATARALLVAAAGAQWGVDPATLTTENGVVTDPASGRTLTYGAL
ADRAAGLPPPTDVTLKSPDQFRLIGTPARRIDTPDKATGTTVYGIDVIRPGMTFAALMAS
PVLGGKVAHVDDAPALAQPGVRQVVVLDDLVAVVADNTWAAQQGLAALDIAWANGPNATL
SQAQLWADIETASKGPGVTAQKQGDALAKLGEGTLFEATYELPFLAHTPMEPLNCTVHVR
DGACDVWVGTQVPGFCQMGAAKVLGIDPSKVTINNHIIGGGFGRRLEADYVVTATRIAAK
VDGPVKVIWSREEDIKQDIFRPLYHDRLKARVENGRITAWHHRITGASILARWLPPAFKD
GIDGDAVDGAIDPPYAVGDILVEYIRHESVVPVGFWRGVGPNSSVFSIESFLDRIAKNTA
VDPVAFRRGLLADNPRALGVLNAATAKAGWGTPAPASPFGARTGRGVALMHAFGSYLACV
ADIAVSDPGDVRVTRVVVAADVGRVINPDTVVAQIQGGVTFGLATVLHDKVTIADGRVEQ
SNFHDYRLIRIDEMPAIEVELIASTEKPGGIGEPGTVIVQPAVANAIFAATGVPLTRMPV
DAALLAKAV
>A0A2C9D4P9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hartmannibacter diazotrophicus|TrEMBL
MVAFTINGSPHTFDGDPEMPLLWFLRDVAGLTGTKFGCGEALCGACTVHLDGIAVRSCQT
FMSDIDGTEVVTIEGLSPDGMHPVQKAWRDLNVAQCGYCQVGQIMQAASLLNDTPNPTDD
DIDTAMSGNICRCGTYPRIRAAIKLAAAGE
>H0SPN0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 375)|TrEMBL
MSIIENPDVVNSASRRGFERHLKVENVSRRAILQTLGLAGGFVLAAPLLSRPAFAAYETG
AGKMPHGTVVDPKVFVSIAPDGIVSILAHRSEMGTGVRTSLPLIVAEEMEADWSKVRVVQ
APGDEVKFGNQDTDGSRSTRHYLLPMRQIGAMARSMLEAAAAKRWSVPASEVKAVNHEVV
HSASGKRLGFGDLAADAASQPVPAVDTIKLKSPKDFRYLGKGQVSIVDLRDITVGKARYG
ADVRLPGMKYAVIARPPVTGGKVKSFDPAEALKVSGVEKVLEVKGWPWPSKFQPLGGVAV
IARNTGAAIKGRDALKVEWDDGPNAAYDSVAYRAELEAAARQPGLVVRQEGDADGALKSA
DKVITGEYYLPHFAHASMEPPVAIADVKGDKAEIWAPVQSPGGTREDVAKTLQIPPENVT
VNVTLLGGGFGRKSKCDFVLEAALLSKELGAPVKVQWTRDDDIQHDFLHTVSVERIEAGL
DKSGKVVAWRHRSVAPTILSTFAAGADHAAPFELGMGLVDMPFEIANIQCENPAAKAMTR
IGWFRSVSNIPRAFAVQSMVGEIAHATGRDQKDMLLELIGSPRVLKLASVKDLWNYGEPY
ESYPIDTGRLRRVVEFVAEKGNWGRSVPKGHGLGIAAHRSFVSYIATIVEVSVDDKGKLT
VHQVDSAIDCGVFVNPERIASQLEGAAIMGLSLAKYGEISFKNGRVQQRNFDDHQVVRID
EAPLITNVHIVPADAETPPSGVGEPGVPPFAPALANAIFAATGKRLRALPIGNQLAT
>A0A7W8STC7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. WSM4180|TrEMBL
MTTLNINGETHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVF
PAAAVGDRKIVTIEALGATPTGQKVQQAWRELDVVQCGYCQSGQVMSAASLLARNPNPSD
ADIDAAMAGNICRCGTYHRVRAAIKHAAKGA
>A0A6J4FLI3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Magnetospirillum sp. LM-5|TrEMBL
MRLTVNGVTHQVEAAADTPLLWVLRDHLGLTGTKYGCGAAQCGACLVQLDGKPAMACATP
VSAAEGRAITTIEGISGRVAQAVTAAWTELDVPQCGYCQSGQVMAAMTLLTDNPKPTDAQ
IDDALSGHLCRCATYQRIRAGIHAAARKLGA
>A4G4C0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Herminiimonas arsenicoxydans|TrEMBL
MSTVFQPEDKDSNLAADLSLPSMTRRTWLKGVGALTGLVLTVGTSGIVRAASSAEIKKYG
GDAMPGGLVDDTLVFVSIGTDGIVTIVAHRSEMGQGVRTSLPMVVADELEADWSKVRVVQ
ALGIEEKYGNQNTDGSRSMRQSFEPMRRVGAAARQMLEMAAAQQWNVKPEEVRAKNHEVV
HAKTGRRLSYGALAEAAAKIAPPSGKELRLKKPAEFRYIGKESTRGIDFQNIVTGNTQYG
IDTRLPGMLYAVIARPMVLGGKVKSFDASAALKVPGVIQVIELKSSPPPASFHPLGGIAV
IANNTWAAIKGREALKITWDDGKHANYNSVEYKKTLQEAARKPAKAVRNNGDTMTVLSKS
SRRIQAEYYLPHIAHATMEPPAATAQIVNGKCEVWACVQAPQATREIVSAHLKLKPEDIT
VHVTLLGGGFGRKSKPDFAAEAALLSQAMKGVPVKVTWTREDDIHNDYFHTVSVERLEVA
LDASGKPTAWLHRTAAPTIASIFSEGAKGEQPFELGMSAVNIPFVIPNFRVEAPEVEAHT
RIGWFRSVSNIPHVFAIQSFVAELAAAAKRDHRDYLLELIGPARKINPKDMSDDWNYGES
PERYPLDTGRMRKTISLATDKAGWGRKLPKGHGLGLAVSYSFVTYVAVVIEVVVAANGDL
SIPRVDIAVDCGPQINPDRIRSQLEGACIMGLSLALSGEITFKDGRAEQGNFHEYEVMRS
MDAPRDIRIHFIHHDFDVPLGGVGEPATPPIAPALCNAIFAATGKRIRDLPVRNQLKAT
>A0A2N0MY78|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ewingella americana|TrEMBL
MEINVNGKMLPLSNVSADTPLLYILRNDLGLNGPKYGCGLGECGACTVLIDGVAARSCSI
PLSGVQGKAITTLEGLGEEGKLHPVQQGFIDEQAAQCGYCANGMIMTLVALFERNPQASE
DQIKNELAYNLCRCGTHLEILRAAEKARQLIAERGQA
>A0A375IIT6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSRLRTSRRRFLQAAGAMPAALVLGFHLPLAKAAEAGAPARDPDDVNAWLRIDADGSVTI
MVPSAELGQGVTTSAPMLVAEELECDWRQVHAELAPTDPVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQGWSVPVGQCRAVQGVVRHEPSGRTLGYGALAARAARLPR
PASVALKDPRDWKLLGRPTDRLDIPLKTRGAAVFGVDVKVPRMLVGSVMACPAFGGTLRR
VDARPALALRGVRRVVPLDDAVVVLADSYWTARKGLAALQPEWQLPRDSLAGDAALMAGY
RDAARRAAAVALRHGEPDAHMQGAQAYTAEYEVPYLAHATMEPMNASADVRADRAEIWGP
TQVCGEIAQRLSGVLGLPADRIAVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPDAAGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHANTDPLQFR
LQLLADRPRPARLLQRLAQHVGWGSAPAGRCQGLALSQAWGSLCATVVELSVQGQRITLH
RIVNAIDCGTVINPATVERQLEGASIWALSAAMTGAITIADGRVQQSNFHDYALLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGQRLRSLPLARHGFELA
>A0A375EX01|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGTVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLQDNPSPRP
EEIRAGITNLCRCGTYPRIERAILRAATALNAGDPKGGASS
>A0A375D6G9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTRFQVNGQPKDVDVPGEMPLLWALRDELGMTGTKFGCGMALCGACTVHVDGTAIRACVT
PVSAVAGRSVATIEGMEGDRVGQAVQQAWIQHNVAQCGYCQAGQIMTAVSLLKTTPAPTD
RQIDEAMSGNICRCGTYPRIRAAIRQAASRLAQGGK
>A0A375CIA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MSHPDTSRRRFLQAAGAMPAALVLGFHLPLAKAADAGTPVRDPDDVNAWLRIDTDGSVTI
MVPSAELGQGVMTSAPMLIAEELECDWRQVRAELAPTDLVYNNRMFKVQATASSTSARWS
FEPLRRIGATAREMLREAAAQGWSVPVAQCRAVHGVVRHEPSGRALGYGALAARASTLPR
PSNVALKDPRDWKLLGRPTDRLDIPLKTRGAAVFGVDVKVPRMLVGSVMACPAFGGTLRR
VDARPALAVRGVRRVVPLDDAVVVLADSYWTARKGLAALHPDWHLPQGKPASDAALMAGY
RDAARSASAMALRHGDPDTQMQGAQAYTAEYEVPYLAHATMEPMNATADVRADRAEIWGP
TQVCGEIAQRLSGVLGLPADRIVVHGTFVGGGFGRREEFDVFVQAALASKAAGQPVKLIW
SREEDIQHDFYRPAAAARFSAVLAPGAAGIRALDARLACSSIYVRNFPDRVKGGVDPKSV
EGVVDLPYALPHVAVRHAMVNTAVPVGFWRGVGYTQNTFFAESFIDELAHHAKADPLQFR
MNLLADRPRPARLLQRLAQHVGWGSAPAGRFYGVALSQAWGSLCATVVELSVQGQRITLH
RIVNAIDCGIVINPATVERQLEGASIWGLSAAMTGAITIADGRVQQSNFHDYPLLRLAQT
PRFEAVLAPSGERIGGVGESAVPTLAPALANALFAATGQRLRSLPLARHGFELA
>A0A375BXQ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTGIAQLSRRGFLRGSLGLMTLAVTSGGLVTMARAADPTPKKFGADSMPGGTVDDPLAFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVVQAEADETRYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPVSEVRAIDHAVVHQPSGRRLGYGELAAD
AARQPVPKGEALKLKPRSGFRYIGKNAVRPVDQQAIGTGRAVYGMDLRLPGMVYAVVARP
PVVGGKLRRLDSRKALALPGVLKVVEIPAFQGAPAFQPLGGVAVVARNTWAAMQGRAALE
IEWDDGPNGSYDSAAYRQTLEAASRVPGKMMRNHGDAQQAWDKAPPAERLAADYYVPHLA
HASMEPPVATVRIRGGSAEVWTSIQNPVAAQTAVARRLELKPGNVRVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPEGTPVKLVWTRDDDIHHDYLHTVSAERLEAVIDKQGQVRSWLHR
SAAPTIASLFTEGAKGQQMFESAMSAINMPYRIDNVRVETAEVPAHARIGWFRSVANIPH
AFAAQCFIAELAHRAGKDHRQFALDLIGPARKIDPGTLADTWNYTESPERYPYDTGRLRG
VIEAATRGAGWGRKLPKGHGLGLAFCYSFMSYTATVVEVAVDAKGEVRVVSVDMAMDCGP
QIHPDRIRAQMEGGAVMGLSLALASEIAFDKGRVVQSNFHDYEVLRHHASPRVIRTHLVN
DNHDLPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVA
>A0A7Z7NPY8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNLHVNNQAVSVECDPATPLLWVLRDHLNLTGTKFGCGVAACGACTVHLDGAAVRSCVLP
VAAVSGKRITTIEGLGSAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPGD
SDIDAAITNLCRCGTYPRVRTAIKRAAKALRERRA
>A0A0N7J9K6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limnohabitans sp. 103DPR2|TrEMBL
MKRRNLILSGLGLTGALVVGWGVMPPRSRLGKPDNMLLTEGDVALNGWIKITKDGGVVLA
MHRSDMGQGIHNALAMLVAEELDVPLKQVRLEQAGHDAIYGNVAMFVGTLPFHPLKSEGP
DKPMMVKTGEWMVSKVARELGVNATGGSSSVKDAWEHLRTAAATAKASLLLSAADQWKVP
AKELSVKDGVVNHASGKSAHYGEFAKGAAGQTPGNVVLKDRKDWRLIGQAAPRADVPAKT
NGSAVFGIDVRVPNMLFASIVQVPQMGGTLSSFDAKEALAMPGVVKCVQLASAAGSAEGF
AVVAKTTWHAKQAAEKVKAQWAQRAEGALDTKRIESELKDKLKTEKGFAFYEKGDAAKAE
SVSARMIEAQYKAPYLAHATMEPMNCTAQFKDGSLEIWAPTQVPGLARATAAKLAKVSDD
KVKVNVTLLGGGFGRRLEADVVAQATQIALALDGAPVQLVWSREEDMAHDFYRPMHVAQL
SAALNAKGEVESLRIKSAGDAISPRWMSRVLPALSGPIDAPDKTTAEGLFDLPYGFANQH
MAHVSTKMGVPIGFWRSVGHSHNAFFTESFIDELAFETKQDPVAFRLALLQQAPRYAAVL
KLAAEKAKWGTALPVGHAHGVALHESFGSIVAQVAEVSIKDGVPRVHRVVCAIDCGTVVN
PGTVKQQVESSVNFALSAALFGKIDIQEGVVQQTNFTHYPLVSLAQSPVVETWIVPSTRS
PEGVGEPAVPPLAPAVANAMFKLSGQRMRALPLLV
>A0A6V6ZGH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF57|TrEMBL
MATNLNVNGTSYQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGLGTPDSMAKIQQAWVDHQVAQCGYCQSGQIMQAAALLAENSSPTD
ADIDDAMQGNLCRCGTYPRIRAAIHDAASKLKEA
>A4A783|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Congregibacter litoralis KT71|TrEMBL
MIEFKLNGKQVSTDSPDDTPLLWVIRDEQQLKGTKFGCGIAQCGACTVQRDGVPVRSCVL
PVSEVAGTEVTTIEGLASPEGSALQSAWVEAQVPQCGYCQSGQIVTAEAFLKSNPNPTEA
EITQAMTGNLCRCMSYTRIRKAIKAAADGELSA
>A0A2S3W0X3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novacetimonas maltaceti|TrEMBL
MTTFHLNGREVTVDVPEDTPLLWVIRDEVGLTGTKFGCGIGMCGACTVHIGGRATRSCIT
PVSAAEGADITTIEGLDPEGKHPVQEAWRELQVPQCGYCQSGQIMQAVSLLKDYPSPTDE
EIDAVMAGSLCRCMTYIRIREAIKKAAAAARGDSSNG
>A0A0M9GD66|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fuscovaginae|TrEMBL
MNSRIEGAEEVLSQLSADPVNLSRRRFLIGTAVGSLVLGFGLPLGSARVQAATAAVERGT
QVPAFLEIRPDNSVRLLCPFMEGGQGTYTAMAQIVGEELDADPATFVVDSAPPGEAYVVM
DNGMRITGGSMSVRMSYPTMRRLGALARAMLLQAAAQQLGVPVTELSTEPGKVLHAASGR
SLAYGELAERAMDLPVPDPGSVKLRDPSQFRWIGKPVKRVDAYDKSTGRALYSIDLKVDG
MLHAAVQHAPRLGMSVGSLRNEEQVKAMKGVHSVHQLPGAVAVVAERWWHAKRAVEALQV
DWKEAAADSPLRVMPADFSSEAYVQRLANEQGPARDAENEGDVAKVLAGAKHVVEASYHN
QYLNHAQLEPPSALARFNADGSLEVWLPNQAPDMFRNDIAKLTGLEASRITLHSPLLGGF
FGRHFLYGSANPYPQAIALAKAVGRPIKLIWSREEEFLRDVLRPIAAVRFRGALDDNGFP
VAIEAISATEGPTEALAGKQGDKIDPTAVEGLAGKSYAIANKRIAQIYVKGPAMLGYWRS
VGNSLNDFFYEAFLDELADKGGKDPFELRLHLLRDNPRLTTLLNAVGELSGGWKRGPFTA
EDGSRRARGVAMASPFGTQTAVIAEVSIDNGQVKVHDIWQAIDPGNIVNPAIVEAQVNGA
VALGLSQTLVEEAVWLDGKPKARNYDLYPILPPSRMARVHVRVVESGEKMGGIGEPPLPA
VAPAVANAVARLTGQRIRSLPLSRYTFT
>A0A3G7JQB3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MTHMTLNVNGSPHELELEPDMPLLYALRNHLGLNGAKYGCGLGQCGACTVLVDDRAVFSC
LTPCSGLEGKAIRTVESLGTAERPGPLQKAFIEAQAAQCGYCIAGMLMRAQALLERDPHP
DEATIREHMASNLCRCGTHLRIIDAIGRVARQERSAP
>K6YG55|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola mesophila KMM 241|TrEMBL
MSARNDIKSVSRRDFLRYTSVAGGALVLGTLLPSITPAWASSTVDDAANTLNLFVSIDND
GTVNIVCHRSEMGQGVRTGIPQIVADELCADWSKVNVVQGLGDEAYGSQNTDGSRSIRRF
YTTMREMGATARTMLENAAAQTWGVPVSDVFAENGAVVHKSSGKSLSFGELAQVASQQNV
PEVKDLTFKSPKDFKFIGKPVTSVDLPKVLTGDTVFGQDVQLDDMLYASIERCPVVGGTV
KAFDKEASRGVANVVDVIEMPEQSFPVLFKNLNGVAVLASNTWSALQGRKALNVTWDLGD
NQSHDSDAYLAELEKRIVTKGKSIRSVGDAYKAFDTADTKLDATYTVPYLVHAPMEPPAA
TAVFKDGHCEVWACTQTPQSTQQNVAGALGIDKSKVKVNVTLLGGGFGRKSKPDFSVEAA
VLAQKTGKPVKVVWSREDDIRHGYYHAISAQHFQAGLDEAGKVTSWVQRTAFPSISWTFT
GTTDEPQTGELSLGFGDLPFAIENLSCETHKAPAHVRIGWIRSVSNIQHGFAIGSFVDEL
AAKSSVSPHQMWLNLIGDDRIVDPKTQGFKYENYGESYDNFPIETKRLKNVLNELMAKSG
ANSPTADNEGWGISVHRSFVSYVAVATKVQVANDKVSVLEMHSVIDAGRVINPDRVKSQQ
EGAMIFGLSIALMGEVTIKEGAVEQSNYHDYTVLRMHQSPKIVTHIIQSDAAPGGVGEPG
VPPVAASVTNAIYQASGKRIRALPVNKVYSV
>C3K9Y0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens (strain SBW25)|TrEMBL
MISQHITVALEVNGHVSEVSAMADTPLLLVLRNDLQLNGPKYGCGLGECGACTVIIDGVA
ARSCVFPLAGAVGREILTLEGLGTRQAPHPVQQAFIDEQAAQCGYCLNGMIMTTKALLDR
NPHPSETEVRNALSGNLCRCGTHIEILRAVLRAARLMTVD
>A0A6J4HDU4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Acetobacteraceae bacterium|TrEMBL
MTLRFTLNGRAVEAEPADAEMPLLYLLREEPFALNGPRFGCGLAQCGACTVLVDGQAVRS
CSVPAESVEGRGVTTLEGLGTAANPHPLQAAFAAERVAQCGYCTNGMIMQAAEFLSRNKR
PTEAEINEELTANLCRCGSHVRIVRAVARAASTMAG
>A0A841PFG5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sangaii|TrEMBL
MASVGKIARRTFLIGAAAVAGGVAVGYYYYRKPFANPLEADLGKSEVTFNPYVKIGADNT
ITVVAPRAEMGQGISTTLAVMVAEELDVGLDQVNVEHGPASYAYYNAAILEEGGPFAFFD
ESMTAQAVRSGLGVVGKLLAIQATGGSASVRDGFDKMRQAGAAARQLLIAAAAQKLGVAA
ADLETANGSILHKASGKSLTYGAVAVAAAAMAPPAEVRLKDRADWKLLGKPQKRIDMLAK
VTGAPIFGIDVRLPDMLYGTVKMSPRFWAKPVKANLAKAEKMPGVIKIVALETNYGHGFG
IIAQNTWAAFKAADAIDAQWADPEYPLSSDAISDVLKQALGAKGSAMRDNGDVDTAFADA
PRERMVEADYAVPYLAHATMEPMNATARFKDGALDIWCGNQAPTLVRQLCANVVGIEQEK
VTVHTTFMGGGFGRRVEMDYALCAALMAKETGGRPIKVTWTREEDMRHDAYRPAAVGKFQ
ARLGDDGLPVAVYMKIASPSMIASTLRRLFPSISPLGPDKSIVDGAYDQPYTIPNYRVSG
VAAPVSIPVGSWRSVGSSVNGFFHEGFMDEIATAAKIDPVEMRKKLMAAYPAAVKVVEKV
AAMAKWGEALPAGKAKGMAFTLSFGSWVGEIIQVADTPAGIRIEKVWIAADVGTALDPGI
IEAQLISAAIYGLSAAMGQEITFADGMVEQSNFHDFDAMRIFQCPVFDVAILENFHKMGG
VGEVGTPPAAPALANAIFALSGKRIRTLPLSKTVAFA
>Q39G66|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MNDLENQHDDIDEGRRNFIVSSALFVAFSLAPASRAVAQAVIADEGAAVHVSKATETLAG
SLKTNPLLDAWIKITPEGKVTVFTGKVELGTGVRTALLQIAAEELDMRPSLITFLTADTG
ASPDEGLTAGSHTIADSGSALLNAAAQVRALLIDGAAKHLGVDPHALTTSDGSIKAPDGR
TMSYGNAVRLVNLHRAATPASPLRDPATFKVIGESLPRVDIPNKVTGGVSYVQDIELPGM
LHARVVMPPVYDSKLQSFDEDAILKMPGIVRIVRNGSMLAVVARGEWQAVTAQRALANGC
RWSTGRSLPDRNTVHEELKRISTQRIEIANTHTATAPATKTLTATFLKNYLLHGSIGPSC
SVAHLENGVLTVWTHSQGVYPLRDGLAEMLSMPKQSIRCVHVEGSGCYGHNGADDAAAHA
ALIAVAMPDQPVRVQWMREQEHAWDHFTPAMVTEISASLDASGHIVDWKYALWSSSHNER
IVNAGRLLPARMLEPPFVSAPSTPMLQPEGGGDRNAIPLYAFPNMHVVNNFSPTMPLQTS
AMRSLGAHMNVLSIESFMDELAHTAGVDPVEFRLRHMQDPRARQVIELAATRFGWPRPPR
ARNRGVGFAFGKYKNLMAYVAIAVEITIVPETGQVILERAEAAVDAGQIVTPDGIRNQIE
GGIIQAASWTLYEELKYDTQRVRSFDWSSYPILRFSAAPRSLNVHLINRPGAPFLGAAEA
SMGPTAGALANAIFDATGQRLREMPFAGERLRRRIDA
>A0A1W7M7L4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MALGGRLTRRGLLVGAAGAVAAGGGLLLAFSLVPRHYATPLRAGDGEHVFDAFIRMAADG
AVSVAVPFCEMGQGITTLVAQIVAWELGADWRRVGVEPAPVSPVYADPVLAAHWAPLWMP
LGAGLAENPDGMLARLKAEREPMMITADGTALAAFEQPLRAAAAGVRAMLAKAAAAEWNV
GWEECEARDHFLIHGDKRLAFAALLEKALAYDPPDPPVLRAGAPAERPRDFPEGARARYP
RLDLPAKADGSFVFAGDVRLPGMVFAAIAHGPQGNSVLSSHDKDAAAGVRGLVGVVHAKR
WLAAVATTWHAANKAVKAMEPRFRAAGPIADSAEIDQALNTALQKGRSVRVAADGDPDAL
LEKAGPVKLGLAARYDVEPALHAPLETATATARLRDGKLELWVATQAPERVRRAGALAAG
VSRADVIVYPMHAGGSFDARLDSRVAAEAASIARQVGRPVQLVWSRWQESLAGLPRTPVS
AELAGSLSPDKQHVLGWRARMALPPTTIESGLRLLHDRGVPDALEASEGRADPLACEGAL
PFYGIPEKAVDHIAASLPLPTARYRGNAHGYAAFCNESFVDELAHAGGQEPLAFRMGMLG
GQPRLAACLSGVARMAMWGGGADASGQGIACHRMDLPTGSGQVRSGFIAVVATARQDEGA
VRVDRLSVFCDIGRIVNMDIARQQVEGGLVFGLAQAIGGSTAYAGGLPVSGRLAQLGLPL
LADCPKVDVAFAESSEEPFDLGELAVVAVAPAIANALFSATGLRFRRLPLLSEGL
>A0A1W7MAS0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sp. MD-1|TrEMBL
MTTINVNGQQREVKVDAETPLLWVLRDDLGLTGTKFGCGIAQCGACTVHLDGAPVRSCQL
PVGEIGNKPVTTIEAIGTTPAGARIQKAWLDLDVIQCGYCQSGQIMSAAALLASNPTPDD
AAIDAAMAGNICRCGTYVRIREGIKEAARHG
>A0A846UH58|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MHFEPTTLELPKHLRAMLDAQQGPAAAEGLPRRNFLKLTAASGFALGAFPLGAMAQDAAK
PGSRSETGLKPTQQPSAFVHIDKDGTTTITINRLDFGQGVQTALPMILAEELDADWSKVK
SVHGSSDPAYIDPVFGIHITGGSGSIAHSYTQYRELGARTRAMLVGAAAARWKVDAASLR
TQNGVVIGPGGKKLGYGELADDAMKLPVPETVTLKDPKNFKLIGKATGRLDAKAKSSGKQ
GYGIDVRLPGMLTAVVAHPPVFAAKLKAVDDSAAKAVKGVKAVLRIPVDRGGEGVAVVAD
GYWAAKQGRDALKLEWDASGVEKVDTAAQLVQYRELAGKPGARKYDADVSKFDGAPHKIS
AEYVFPYLAHAPMEPLNCTVRAADGKVELWMGSQMPGFDGLAASKVLGVPPQNVQVHVQM
AGGGFGRRAIPSSDYVVEACNVVKAAQAAGIAAPIRTLWSREDDVKGGYYRPMHLHTAKI
GFDAQGNVLAWDHVIVGQSIMAGTPFEPMMMKDGIDGTAVEGMKEPYAVPMRLTVHHPKQ
NVPILWWRSVGSTHTAFAMETLVDEIARTTKQDPVAYRMKLMGDEHPRHKAALQLAVDRS
GYGKKTLAPGRAWGVAVHESFNSVVAYVVEASVKDGTPTLHRATAGVHCNLVINPKTLEA
QVQGGALMGLSMCLPGAAITLKDGVVEQSNFGDFVVPRITDMPQIEVHTVPSGDAPTGMG
EPGLPPLAPAFANAVASLTGKPIRELPFKLA
>A0A1N7SIK2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ribeironis|TrEMBL
MGSLNINGRAVTVQAEPDMPLLWVLRCELGMTGTKFGCGVGICGACTVHLDGDASLACKT
LMSDLHGQKITTIEGLQGAEAQALKAAWLDLDVVQCGYCQSAQLMAACALLRHKPAPTDA
DIDAALSHIVCRCGTYPRVRAAIHQAAAKRRPV
>A0A0H3KMZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MATTFVLNGKSVTLDADPSMPVLWAIREHAGLTGTKFGCGMAQCGACTIHLEGQPVRSCV
LPLAGIADKHVTTIEGLQSKPAQAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPKPTD
ADIDAAMNGNLCRCATYARIRAAIHDAAATLGA
>A0A6J5GKU6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MGEIVNMSRRGVLKGTLAGGVVLGLQIGGAGTALAASVLSSANGAKGTFAPNVYVSVAPS
GEIILVVHRSEMGTGIRTSLAMILADELDADWNAVRVVQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGTARQMLLAAAAVQWRVAPATCHTEPGHVVHAASGRRVAYGALATAAARQPV
PGRDTLHLKDEGTWRYIGKSLPIVDLDDIVHGRATYGIDVVLPRMTYASIERSAVYGATL
KSVDSTETMKVPGVLHVVRIPAAPLPAGFQPLGGIAVVATSTWAAMQGRRKLRLDWDLGP
NASYDSQAYREALEDTARQPGKIVRNNGDTAAALKSAAHHVSADYYVPHLAHAAMEPLAA
TASYANGAVEVWTATQNPQQARTTVAQVLGVQEPAVTINVTLLGGGFGRKSKPDYVAEAA
FLSREVGAPVKLTWTREDDVHNDYFHAVCAQHMEGGLDAQGKTVAWLHRTVFPSISSTFN
ADVRYGAAGELGQGVTDMPYDIANVRCENGAASAHTRIGWYRSVYNIPHGFALGSFVDEL
AAAARQDPVQHLLTLLGTPRHVDLHALGVDYPNYGASIDEYPIDTARYAAVVRAAAVRSG
WSTALPARHGRGIAVHRSFLSYVAAVAHVQVADDGSVRVTRVDLAVDCGRIVNPDRVVAQ
FEGAVVMALGNTLYSELTFRNGASEQSNFTDYEVARIDSVPETHVYIVPSDAPPGGVGEP
GVPPTSAAICNAIFNATGQRIRALPVDTSLLKRA
>A0A6J5GUR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia fynbosensis|TrEMBL
MTTDFDLTGAVRPSRRAFLKAAGSVAAVGLTVGFEWAGTGRRALAATMPEATFAPNAFLR
VAPDNSVTVIAKHVEMGQGAYTGIATIVAEELDADWQDVRVESAPADAKRYANLAFGTIQ
GTGGSSAMANSWMQLREAGAKARAMLVSAAAAQWQVPASDLTTRDGSVHHAATNRTATYG
SLASAAARLPVPEKVTLKSPKDFRLIGHPLPRVDVPPKTDGTAQFTLDVTFPGMLVALLQ
RPPLFGATVKSFDASAAKAVPGVVSVVQVPGGVAVVAKGFWAAKQGRDALKVDWEDSKAE
KRSSDAIMTEYRRLAEQSGASARKEGNATQALAGAAQKVSATYAFPYLAHAPMEPLDAVV
KLTADSCEIWAGDQFQTVDQGNAARTAGLDPQQVKIHTLYAGGSFGRRANTQSDYIVEAV
SIAKALGANGTPVKLQWTREDDIHGGLYRPMYFHKLDAGLSADGKLIAWRHRIVGQSILA
GTPFASAMVKNGIDGTSVEGAANVAYAIPNISVELTTTQTGVPVLWWRVVGSSHTAFAVE
AFIDEAAHAAGKDPFVFRRDLLAHEPRMRAVLELAAQKAGWDPAKPLPKGRGRGIAVAEA
FKTFVAQVAEVSVDNEGNVKVERVVCAVDCGTPINPDVIAAQMEGGIGFGLGAALHSAIT
LKDGKVEQNNFDGYQVLRIAEMPKVDVHIVQSGEAPTGVGEPGVAPVGPAVANAIFAATG
KRLHSLPFPGAAGKSA
>A0A238JFG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas phthalicica|TrEMBL
MANIAKIARRSFLFGSLAIAGGVALGTWYVAKPAPNPLKPGPDEAALNAFVLINQDGVTL
IAPRAEMGQGVQTTWAALLAEELDVTLDQVTVLHGEPAHAYFNTAMLGESLNTKGYDDSA
FQHLMAQAMGRIGKVLNFQVTGGSTSMRDGYERMRVSGATAREMLKAAAAERLGVDVKQL
QTENGQVLAPGGITLPYRELAKEAAKIDPPKVTLRPRSEWKILGKSQPRIDMLGKSTGTA
QFGIDTRLPGMKFASLRMSPKRAGMKSFDASAAKSMPGVEKIVDMGDGVAVIASNTWLAM
QALDAIEFVWEPADFEASSDEIFAKIESAFEQEPNSAFRDDGDVDQLPAGSETLSAEYRV
PFLSHASMEPLNATAWIDGSKLRIWTGTQSPSFVQSACADEAGISAQDVVVETTLMGGAF
GRRGEFDYAILATRVAKAVPGTPVQVTWSREEDMTHDFYRPAAIARLRGGLHEGQPVALD
VQVSAPSLSDQIMKRWMGRDGGGADRTIIDTAYNQPYGFPNYRARGYKADTKPPLGAWRS
VGASFNGFFIEGFVDEMAHAAGQDPLDFRLTLTSAEWEPAYNVLQAVKDMSGWTGTTPEG
IGRGVAMVYSFGTPVAMVIEVQDVDGSVRLNEAWIAADPGVALDPSIIEAQLFGGMVYGL
SSAMGEEITFADGAVEQQNFPDYEPLRMPQMPKVTVRILETQEHISGIGEPGTPPAPPAL
ANAIFDLTGQRIRQLPLNKEIDFYI
>A0A238JDB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pelagimonas phthalicica|TrEMBL
MSKTITVNGAEHHIDLPGEVPLLWVLRDQLNMTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALEDVEGAVTTIEGLGTPEMMHRLQQAWVDHQVAQCGYCQSGQIMQAAALLDTTPNPSD
ADFDEAMAGNLCRCGTYPRIRAAIKDAAGLEG
>A0A509DU32|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassocella blandensis|TrEMBL
MIKLKVNDKSVEYNGDPNQPLLWYLRDDLKLTGTKYGCGIGACGACTVHMNGSPVRSCSL
PMAALGSSSIRTIEGLSSNVGKEVQQTWKELDVVQCGYCQSGQIMSATALLESNPKPSST
DIDNAMQGNICRCATYQRIRQAIGQTAKKLEG
>A0A2R8C4J3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria mediterranea M17|TrEMBL
MATTLTINGKTHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHINGEAVRSCQ
TSLSDVDGPVTTIEGIGTPDSLAAIQKAWVENQVAQCGYCQSGQIMQAASLLAENPSPTD
ADIDDAMQGNLCRCGTYPRIRAAIHEAASKIKEA
>A0A2R8C303|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Falsiruegeria mediterranea M17|TrEMBL
MTLNTSRRGFLKGAAAASAVLLVGARPDGALAGGASQGAKLNPFVKINADGMVTAIVKHF
EKGQGPATGLTTLIAEELGVSMEDIAYEFAPSDPGTYNNLLFGPVQGTGGSTALANSYMQ
YRQAGAAAREMLIQAAAKEWGVKASTLDIVDGQVTDGTNQAPLAQFVAAASQLSAPENPR
LKEPSEFRLIGNAKVQRKDTPPKINGTAKYAMDLHLDNQMVAVILRSPRKGALVTGFNDA
DATGIKGYIRSAVLPNKAGVAVYAEHTWAAFQAREALSVEWDNSNAEMRSSDQIREQLIA
AVNADPTYELTETSAAKAQLSMDGAATVLEETFYFPLLAHAPMEPLTCTIEAAAEGGVIL
HDGCQFPTVPHGALSQILGLPMDKVQINTMFAGGSFGRRATPVADYQVEAALAFALTDRS
RPVKLVWSREDDITGGFYRPAVAHRVRVGLNADGDIMGWDHRIAAQSIMKGTPFEAMAVH
NGVDHSSVEGVTQSPYVIPQQHIGLTDVAPATTVLWWRSVGHTHTAYVMESMMDAAAKAA
GRDPVEFRLSYLTGDGADQKRMADVLKLAAEKGNWGAAPEGRDQGIAVHKSFNSYVAEVV
EISRDEDDYVKVEKVTCAVDCGVAVNPDVIKAQMEGGIGYGIGHVMRDEITLTEGVVDQS
NFPDYEPMRIGDIGAIDVHIVASNEAPTGVGEPGTPPSAPALANAIAVSGPRVTALPMIN
NGVDFV
>A0A6S6SRD4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Thiotrichaceae bacterium|TrEMBL
MKHLFSLLENNDSSDASTVDSQVNRRDFLKFVVIGGAGLTLGLSLDSAHAEMSGPGKTSA
DESLTNGQFAPNAFIRIEPDNTVHVIIKHLEMGQGTFTGLSTLIAEELEADWSQIKPHAA
PANAALYNNLLWGPAQGTGGSTAIANSFEQMRKAGAAAKMMLVAAAAQLWDLPADEISVS
QGVVSHKASGKSASFGELAELAAKQDVPEPEEITLKDPKDFVLIGKRIPRKDGGKTDGTA
IFTQDIKLDGMQTAVVTHSPRFGGKVKTFNADKARKMPGVTDVVQISTGIVVLATDFWSA
QKARETLDITWDNSQAATASSEALLTEYKTLAKKPGLPAKKTGDADQAFKNAAKVIEASY
EFPYLAHAAMEPLNCVAHFTGDSCEMWYGAQIHTMDQGAVAALLDLKPAAVKINTLYAGG
SFGRRGNPKSDYVLEAAEIAKAKKGTPIKLVWTREDDMRAGYFRPMYYHTLKAGLDKDNK
LVAWEHRIVGQSIAKGSAFEGMMVQKGVDVTSVEGASNLPYDIPNMHVELHTTDPGVPIQ
WWRAVGSTHTAYSTETFIDEIASAAKIDPIAFRLKLLTNKPRHHGVLKLAAEKAGWDSKL
PKGRSRGIAVHESFNSYVAQVAEVSVQDDGSYKVERVVCAVDCGIAVNPDIVKAQMEGGI
GFGLAPTLVSEITMDNGAVKESNFHDYQVLRMNQMPDVEVHIVPSAQAPTGVGEPATPVI
APAVANALFNATGKRYYRLPIKKA
>A0A7D5NEF8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Kapabacteria bacterium|TrEMBL
MENNTSQSRRRFIFGTALTLGGIVSGFAFSNKALAELIVFKDEKKILGFAPSVWVEITKD
NFVVVTVARSEIGQGIKTTFAMIVAEELDADWSKVIAVNSQGDPKYGDQSTGGSTSVRMF
WTNLRQAGAQARQMMINAAAQIWGISPDDCYTENSYVYERNGTRKLAYGELIETAMNLPV
PPLNSVKLKSSSEFKILGKSQKNLEEPNYVTGKTIYSFDFRYPGMKYAVLLRCPYIGGSV
KSFDATDALKQNGVIGVYQIEEGIAVVADNSWAALKGREALKVQWNEGPNANLNTEQIYE
TFRSLIVNTGQLPSKTVKEIDVRFEVPFLAHSTMEPMCAFANFKDGKCEIFAGTQNPQYA
REDVARALKISKDNVTVNVLNSGGGFGRRLNSDYITIAAKISKASGLPILFFYTKADDIK
FDYYRPASVHAIKAGIDSNGKPTGMIHIIASQGGVWPVDPPYNVGGYNYELKSSAFGIRE
GAWRSVENTQNIFAIESAIDELAYLAGKDPFEFRLEITTDQKLKNVLSKVAQNANWGSSL
PSGWGRGIAAFVGYGAYITHVVEVYVSNEGFLNVKKIYAVVDPGFPINPENIRNQIQGAA
IDALSTALYAEITIEGGQVQQSGFHNYRWLRMDEIPEFDIEILRTSDNPSGMGEVGFPSV
TPALCNAIFNATGIRIRKLPISRTPLTSVEKQLTKDNYFEVNAFPNPFESSVKIEITPRS
VLNKKLDVEIYDYLGKKVIEPKFKYDSAKYFADVNFEILPPSVYYVVVSFGAERFSFPIM
KVK
>A0A238KAL3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Octadecabacter ascidiaceicola|TrEMBL
MRLTVNGTEHEVDVTSDMPLLWVLRDELNITGPKYGCGIAQCGACTVHVDGFAVRSCQLA
VGDLAGGHVTTIEGLASPEGLHAVQEAWIEHQVAQCGYCQSGQIMQAASFLETNPEPTDE
DIDAAMSANLCRCGTYPRIRAAVHAAAKKLQEA
>A5EP17|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MIKVKINGQEQSWDGDPSLPLLWYLRDELGLTGSKYGCGQALCGACTVMVDKEAARACIT
AISDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLNQNPKPSHD
QIRDAMSGNICRCGCYQRIENAVHLASTGV
>A0A177GBE4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MSGGGGFLLSAFLPGLPLLKASHAQDTATGVVFRPNAFIRITPQGSVTLIMRYAEMGQGI
YTGISMLLAEELGVTLDQVSVEAAPADPAYVDSVAGEEETGGSSSTRDSWIPLREAGAAA
RMMLVSAAAKTWGVPENXCQXXXGRVFHSXSXRXXSYGELAEAAMHQAVPAKVTLKPASD
FTLIGTSPRRLDTKAKTNGSAQFGIDAQIPGMKIGRITACPVKGGHLTGYNRDAALAVPG
VVDVLTLPDAIAVIGEHMWAAIKGMEAAFPQWEYGPNATTSTDDILARMKKSSEQSGVVA
VKNGNAQDALKQAHTRIDAVYELPFLAHAPLEPINTTLHIRPDGADVWVGTQVPGRAQQE
VAEATGLRAESIAVHNHLIGGGFGRRLDSNSIGQAARFAKQVFLPCQADLDARRGHDAGS
VPPVLLRSNFRRFDPGRRD
>A0A1E1V206|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bosea sp. BIWAKO-01|TrEMBL
MISASADTSPTLSRRTMLAGSAAAAGAFTFGFAIPFADEAMAQGAVKEINAWVVVHPDDK
VVIRIARSEMGQGTLTGLAQLVAEELNCDWARVTTEYPTPGQNVARNRVWGNFSTGGSRG
IRESHEYVRKGGAAARMMLIQAAANQWGVPAADCSAEKSIITHKASGRSLRYGQVAEAAS
KLEAPKDVPLKDPKDWTIAGKPLKRLDTVDKTNGAKIYGIDLNMPGMLNAAIKDCPVFGG
KVKSFDAAKVKAMPGVTHVVPVGETAVAVVAETWWQAKTALDALPIEWDNGENAKVSSES
IAAWLKEGLDAPEAVIGNQVGDAKAAIARAARVVEAVYSYPFQNHATMEPMNATARYTPE
RCEVWTPTQNGEAALAAASEASGLPIAKCEAYKIDLGGGFGRRGAVHDWVRQVVAIAKQI
PGTPIKLVWSREEDMLHGRYHPVTQCKLTGGLDKDGNLTGLHMRISGQSIVAGIFPQNIQ
NGRDPAVFQGLNPPGPEASIGYGIPNLLIDHAMRNPHVPPGFWRGVNLNQNTIYLECFMD
ELAHAAGKDPLEFRRALMKNYPKHLAVLNAVAEKAEWGKALPAGVYRGICQTMGFGSYVA
AVAEVSVSAEGKLKIHRIVAATDPGHAVNPAQIERQVEGSFVYGLSAALYGECTVKDGRM
VEENFDTYTVLRLDEMPVVETVIVPSGGFWGGVGEPTIAVAAPAVFNAIFAATGKRVRSV
PLKNVDLRKA
>A0A840FI67|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas jinjuensis|TrEMBL
MTRFTVNNQPVEYRLDPDTPLLWALRDASNLTGTKYGCGTGQCGACIVDVDGRAVPSCRM
TIAEAEGTYVTTIEGLSRERNHPLQLAFIAENVSQCGYCIPGFIMAASVLLRKDADPSEE
AIRSTLTNLCRCGIYPRVVEAVQRAGRALRGEEVIPAGARPGIDPADAARVVPALVPPAR
>R7ZSP1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lunatimonas lonarensis|TrEMBL
MTRKFNAIPMKPINNDNPYTFPEQYELYEQRFLAAPITRRAFFKRMGMGMASFVVLGDVL
ASHAADWLAAKPDEDTIAAWIHVGEDNRITVYTGKVEVGQNIRTSLAQAVAEELFVPVDS
LSLIMGDTELTPYDRGTFGSLTTPQMAPVLRRAAASLREMLKEAAASEWSISKNSLQLDK
GMVSHPSNGKRLSYGDLAKGKELLKPIDKNAPLVPATAWKIAGTSVPKVEGIQFITGKHR
YVSDMVLPGMQYGKILRAPANGARLLSVNTERAEALSGVRVVREGDFVGVTAPSTQSASL
ALALIEASWQNSPQVSRSALFEHLTTSARAGKGVGATVSSAISNGAIQRSERFLIDYIAH
VPLEPRSGVAEWKGDKLHVWTGTQRPFGVQEELQRAFGLPKENIRVFMPDTGSGYGGKHT
GEAGIEAARLARAIGRPVKVTWTREEEFKWAYVRPAGVIEVNSALDSNGKLSAWEFYNYN
SGGAGIEIPYDVGEKHHQFIPSDTPLRQGSYRALAATANIFAIESHLNDLAAEASIDPVT
FRLAHISDDRLKAVLQASVEKFGWDRSKPAQAGFGVACGTVKGGYVGTCAEVEVDSGTGL
VKVKRLVVSFECGAIVNPRHLESQVVGCVLQGLGGALFEAVDFKDGEVLNPFLSSYRVPQ
FSDVPSIEVVLLNRVDLSPAGAGEAPIVCVAPAIRNAIFDATGKRLNRLPMIPGGRLPV
>A0A0H5DII6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter italicus|TrEMBL
MSTTLRINGITHQVDLPDDVPLLWVLRDEVGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALSDVWGDVTTIEGIGTPDTMAAVQQAWVANQVAQCGYCQSGQIMQAASLLAENPSPSD
TEIDEAMQGNLCRCGTYPRIRAAIHDAAKMMKEA
>A0A0H5DEQ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phaeobacter italicus|TrEMBL
MTTQLSRRGFLKTAAAAGAVLYVGVQADGAMAASKSADALLNPFVKIGSDGNVIAIVKHF
EMGQGPATGLTTLVAEELGVSMDQISYEFAPSDASVYNNLLFGPFQGTGGSTAMANSWMQ
YRTAGANAREMLIKAAARDWGIDAAELDIQNGQIIGAGNAAPLGEFVTTAADFAPSETPR
LRDPAEWKIIGKASTRRKDSPIKINGEAKFAMDVQLDNQMVVMIKRTPQRGGTVASFDDS
AAREVKGFIMAQTLPTNHGVAVYAETTWAAMQARNALNVDWDLSAAESRSSQDIRDEIMA
ALDADPVFNVNQADLASVRSTVDGAAKVVEKTFYFPLLAHAPMEPLNCTIEQTEEGDIVL
HDGAQMPTGPHMAYQQIFGLPADKIHINTMLAGGSFGRRATPDADYQVEAGLAFVMTDRS
RPVKLVWDREDDIRGGYYRPAFGHKVRVGLDEAGTIIGWEHQVAGQSIMKGTSFEGFAVR
DGIDHSSVEGIADSPYTIPGQALGLTDTEKATSVLWWRSVGHTHTAYVMEVMMDLAARAA
GKDPVEFRLAYLTGEGDAERKAAALKLAAEKAGWGKAAPGRVQGIAVHKSFGSYVAEVVE
LSGNLDDGIVIEKVTAAVDCGIAVNPDVIKAQIEGGIGYGIGHAMRDQITLDGGAVEQSN
FPDYEPLRISDIKEIETHIVASAEAPTGIGEPGTPPSAPALANAIAQLDVVVAELPMAEN
GVSFA
>A0A0C4Y8F3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus basilensis|TrEMBL
MKRRAFLVAGIGGAGALLVGWSVLPPRQRLATSQPLPAVGTQVGLNGWVKVAADNTVTIM
MCRSEMGQGVHTGLAMVLADELDANWAQVKVEHAPVDKIYNNLEVVVEDLPFRADDDGVA
RHLAAWLTRKLMREIGEMVTGGSSSLNDLWNPMREAGASARAMLIGAAAARWNVPAGACR
AQDGKVLHPSGKTATFGELAAQAGQLPLPAKVALKTPSEFKLIGKDIRRIEAASKIDGTA
RFGIDVLPEGLLYASVTMCPTLGGTVASFDGAVAAAMPGIVKVLAVDAYNGGTGGVAVIA
DNAYRAMKALDAVKIVWNPGAAASLSSPEVSRRLAQALDASDGHAYYRHGDVDAALKSAA
KPVSAEYSAPYLAHGAVEPINCTVQVRDGAARVWVSTQLPGLARRAVSKVLGIDADKVDV
QPQLIGGAFGRRLEVDFISQAAAIARAGGGRPVQTIWSRVQDTTHDFYRPACLSRFKAGL
DGAGNLVAWHNTSASQAVVPAMLARLLGLPGLGIDKTTTEGAFDRPYEWPNARVGHVIVD
LPVPVGFWRSVGHSHQAFFTESFIDELAAAAGKDPVAFRAGLLARHPRHLAVLHMAADKA
GWAKPLGKTADGAARARGVALHEAYGSIVAQVAEVSVAPDKTVRVHRVVCAIDCGLPVNP
NLIRQQMESAIIFGLSAALFEEITIVDGQVHQKTFGDFPVIFMNNCPAIETYIMPSQDHP
QGVGEPGTPPIAPAVANALFALTGQRLRALPLKLA
>I2GGG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrisoma limi BUZ 3|TrEMBL
MSDKAIPRREFIRLSGLAGGWFGLSICLPSTASASVVNEPDGSFSPDVFVEIGRDNTIIF
NLPKQEMGQGISTGLSMIFADELGADLDRMIIRQADYDPRFGNVVQGVTGGSNSMRACWQ
PLREAAARVRELFISVAAERWQVEPTSCQAENSFVIHRPTGQRVSFGALIEQAAQKPAPA
EARLKDPAEYRYIGKPLGNIRNRNVVLGQMRYGIDQGVPGMVHAVITRCPFFRGHLRHYD
DSAARNVPGVIDVVEIKPIRKAVKLSPDDNNPTTYPYTIAAGIAVVATSTWAAMQGRNAL
ILDWDSGPFGNVSSQTLAEQLRAAEQESGEELFRYGSVDQTVAQANRIIEAQYDTQFQAH
AIMEPLNAVAHVKNSQCEVWVGHQYGRRVAEEAATFLNLPVDQVTVHILPSGGAFGRRWE
ADFALEAVIISSQIGKPVKVTWTREDEIQHDYYHAYERDHHRAGVDAQGNLLVWDLKRYT
FDFFAGWSWNPYRYGVPASRMQAVLLESPLQTGSWRSVDSHRETFARECFVDELAHALGK
DPLAYRLDLLSKPLLVPVGIDNPDNWLKRAEDERRKTRQILELVAQKAGWGSRKGLGIAV
TNYCAQVVEVALENGKLRVKKVTAAMDCGRVINPSLVRGQVEGSIIWGLQAVLYGGITLI
EGRVQQSNFHDYKMIRMSESPPIDVHLVDSQEPPTGTGEPGVPALAPALLNAIFALTGQR
IRQIPMGTDLF
>I2GBE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrisoma limi BUZ 3|TrEMBL
MKQQPSLSLNRRAFLKTGGLTVSSLVIGFNSAQAGSELVNLSERVAEKALVSLEVSPLVI
LENTGKIILMAHKPEIGQGTFQSMPLIVAEELEVSLDQVEIRQAMADKKFGNMGVGGSYS
VRSEWANLRKAGAAAREMLTQAAAKTWNVPVDECYAREGKIFHKPTGKSSSYGALTEIAK
TLDVPKEPKLKDAKEFRLVGKPSKRPDIPAKVTGRAKFGIDAEVPGMLYASVDRAPVMQA
TIKSFEDTAAKKIPGVQHVLKAERKMNKNTFQGVAVLADTYWAALQGRRALKVEWDNGQY
GAFNSADITARFKELAKTDGHVDTNKGDFDTAFAGATKKLEADYELPFAAHAPMEPQNCL
ASVKGDTVEIWTSTQLPDDVQKETAKYLNIPPENVMVHVLFVGGGFGRRLFLDQVMEAVY
LSKQVGRPVKVVWTREDDMAGGPYRPATYSRLRAGFDGAGKPVAFQHKVVAPSINDTQFG
SKDPAKRQDDGAMEGLKEAPYDIPNLRFNNVFADVPVPMGWWRAVYSATTCFAHESFVDE
MAHAVGQDPLAFRLNLIGENTRMKNLLTFLREQSGWEKPLPAGWGKGVAFWQFFAGQAGH
VVYVSKTDKGVKIEKIVAAVDCGTAVNPDNVRSQIEGGTVMGLTAALKSAITFEEGRAKQ
TNFHDYQMLRLNETPPIEVHILPSSESPIGVGEPGLPPAAPALANAIFAATGKRVRKLPF
DINDLG
>A0A5P9H260|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. THAF27|TrEMBL
MKLTVDGTVHDIDVAEDMPLLWVLRDLLGKTGVKYGCGIAQCGACTVHIDGEAVRSCQVP
AQDVWGAVTTIHGLGTPESPHPVQQAWIETQVAQCGYCQSGQIMQAAALLSEMPDPSDEE
IDDALSGNLCRCGTYPRIRAAVRVAAAKLKNA
>A0A5P9ELM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter sp. THAF39|TrEMBL
MAFSLTINGQRHTVDVDSDTPLLWVIRDEVGLKGTKFGCGAGLCGACTVHVNGQPARSCS
TPVASVDGASVTTIEGLSEGGQLHPLQQAWIDQGVPQCGYCQSGQIMTAAHLLDNNPSPS
RQDIVTAMTGNLCRCGTYSRIVAAVETVAGSVGQYEPAGEDA
>A0A3B1ANM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MAHDFYRVGGFHSFKGGVDPEGKVTFLQDHLITFSNNGEKPVIAGAPRQPSQVFPAQLLN
SFRLSQSMLPLKTRCGLLRAPGSNTTAWAVQSFLHEMAVAADIGPVVNLSGAESQCQGSV
IDGFSTMLGQEITIENGRIQQSNFDTYPLLRMPDAPNVDVHFIQSDNPPTGAGEPALPPL
APAICNAIYAASGYRVRTLPLTKDGFSV
>A0A445ZWY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. JV551A1|TrEMBL
MELRINQKTYQVEADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIEADAVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPKPSDA
QIEAAMVNLCRCGTYNAIHAAVHELAQGEKA
>A0A7W6D5C1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MIPKMMQSMTLPAKSVQASRRQFLLGALAAGGGLAVGFNIAAMAPALASETAAGDGQHSF
SPYVVIDGDGKVTVLSSQFEMGQGSYNGLATLVAEELGADWATIDVVGAAGNVKVYGNIA
FGGAIQGTGGSTSMVTSWERYRKAGAAARTMLVAAAAAEWGVNAAEITVENGVLSHPSGK
SGHFGVFAAKAATLPVPAEVTLKQPAEWTLIGNEKLKRFDSARKANGTQQYTIDVKLPGL
LTAVMIHPPLFGAKVKSFNAEEAKKVKGVVDVVETPRGVAVVGDTMWAAIKGRDAVTVEW
DDTGAEKRSTTDLMAMYRDLAGKAPVATARNDGNVETGFASAAKVLEANFEFPYLAHAPM
EPLNAVARMNEDGTLEVWGGLQFPDVQQQIASQIAGVAVDKVHLHVMKAGGSFGRRATFD
GDIVAEAVHVAKAIGFRAPVKVQWTRENDMRAGRYRPAYVHSVKAGLDADGKLVAWENHV
VGQSIMAKTAFEGSIQNGVDPTSVEGANNLPYAIPNQKVGLTTTEVGVPVLWWRSVGSTH
TAFAAEVFLDEVAEAAGRDPVEFRLSMLEPDSRHAVVLKLVAEKAGWDKPLPEGRFRGVS
VAESFGSVVAQVAEVTADGSGGIKVERIVAAVDCGLAVNPDQVRSQVEGGIGFGLGSILG
EEITLTGGQVDQGNFDTYTPLRIDAMPTVEVHILASANAPSGIGEPGVPPTGPAVANAAY
RALGKRIRVMPFAKALNA
>A0A841MFS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MAQYNLSINGKSMNVDVDPNTPLLWVLRDHLDLVGTKFGCGIAQCGACTVHIDGEAVRSC
SYPVSVIEDKKVVTIEGLSEKGDHPVQKAWLEHDVPQCGYCQSGQIMTAASLLAENPNPT
DEEISYAMNGNICRCGTYTRIKAAVKTASKSL
>A0A841MHG5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Algoriphagus iocasae|TrEMBL
MLPNIPFLQKNKREDQSKVFVPSRRDFLKLGSLATGGLILGVNFQCSGPKGELVTFAPNV
YLTIDSDNLVTLVAHRSEMGTGIRTTLPQIVADELGADWSKIKIVQAEGDEEKYGNQNTD
GSFSVRMFYEPMRKAGATARQMLIAAAAADWGVDEAECDTKDGMVHHLGGKSASFGDLVG
KLKDMPVPAAENVKLREFSSYNLIGTDVPIYDLKNITVGKAVFGADVDLPNMKIAVVKRT
PVIGAKIISYNDEKALAVPGVVQVVKIEGSGFPPGLDKALEGVAVIADNTWAAIKGRDAL
EVEWDLGENQNYNSADQLAEMLQSTKGKGKVRRERGDFDGANSSASKKIERTYEAPFYAH
ATIEPPAAIAHVKADGSCEVWAPTQHPQWARGAVAGALGLDASKVKVNVTLLGGGFGRKS
KPDFVVEAALISKAANAPVRVQWTRDDDLHFDFFHSQSAQRINATLDSSGKLTGWNHHTV
FPAIGSTSSKEELHPSDGEMGLGCVDFPFDVPNIRIESHESTGNTRVGWLRSVSNIHHAF
AIHSMMDEIAEARGKDPIENALELLGEDRDITFQPEMVDGEYPNYGEKIEDYPWNTGRMK
NVIQTLKEKSNWTANKEAGKIMGFAAHKSFLTYVGCVVILEKGSDGKILIPEVHYVVDCG
VAVNTDRIRSQFEGGSQFATSLATTSAITFENGQVQQNNFDTYQIIRMPASPKKIHVHIV
ESQIKPTGVGEPPVPPFIPALANAMYRMNGQRIYKLPFKV
>A0A143GKI9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas yamanorum|TrEMBL
MNVRIDPAALPLVAALNDPVNLSRRRFLASTAVGALVIGFGLPLGSGRVQAATAAAAGER
GTQVPAFLEIRPDNTIRLLSPFIEGGQGTFTAMAQIVGEELDADPATFLVECAPPGEAFV
VMENGMRITGGSMSVRMSYPTMRRLGALARAMLLEAGAQALKVPVGELSTEPGKVVHAAS
GRSLTYGELAGRAMDLPVPDVASVKLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDMKV
DGMLHAAVQHAPRLGMTVGSLRNEDQVKAMPGVHSVHRLPGAVAVVAERWWHAKRAVESI
QVDWLEPTADSKVRGMPKDFSSDEHFKRLAAETGPARDDENEGDVAGTLANAKTKIEATY
HNQYLHHAQLEPPSALARFNADGSLEIWLPNQAQDMFLADIAKRTGLDPSRITLHSPLLG
GFFGRHFLYDSASPYPQAIELAKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRGALDSDG
WPVAIEAVSATEGPTEALAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPVMLGYW
RSVGNSLNDFFYEAFLDELADKGGKDPFELRLHLLRDNQRLTTLLKAVGELSGGWKRGPF
VAEDGSKRARGVAMASPFGTQTAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVSLGLSQVLLEEAVYVDGLPRARNYDLYPVLPPSRMARVHVRVIESGEKMGGIGEPPL
PAVAPAVANAVATLTGQRIRSMPLSRYSFT
>A0A7W6AGU9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium brachythecii|TrEMBL
MLKLTVNGVPHDVDADPEMPLLWAIRDRLNMTGTKYGCGIAQCGACTVHMDGQPVRSCQT
RIGDVGEAKITTIEGVSGKVAEAVQGAWRNLDVVQCGYCQSGQIMSAIGLLTDNPKPSDA
DIDGAMEGNICRCGTYQRIRAAIHEAARTLG
>A0A6J4MA51|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Microvirga sp|TrEMBL
MNQVAHLPRRGFLQVSAALGAFTLGIRVPEAGAQGAAQGAAQGAAPPEVNAWVVVKPDDS
IIIRIARSEMGQGTLTGLAQLVAEELNADWSKVSTEYPTPGQNLARNRAWGNMSTGGSRG
IRESHDYVRKGGAAARMMLVQAAAGAWGVPAGECRAANSTITHQPSGRTTTYGKVAEAAA
RLTPPTDIPLRDPKDWTIAGRSLPRLDTVEKTNGKQIYGADLTLPGMLNAAIRDCPVFGG
KVASFDATKVAGMPGVKKVVQVGETAVAVVADTWWRAKTALDALPITWDNGPNAQVSSAS
IAEVLKAGLEAPEAAIGNRAGDARAAIASAAKRVEAVYGYPFQNHATMEPMNATALWTPE
RCEVWTPTQNGEAALAATSEAAGLPPAKCEVYKIHLGGGFGRRGALHDWVRQAVDIAKQM
PGTPVKLLWSREEDMLHGRYHPITQCKLTGALDAQGNLTGLAMRISGQSIVAGIFPQNIR
DGRDPVVFQGLSPGGDEGAFGYAIPNLLIDHAMRNPHVPPGFWRGVNLNQNAVYVECFMD
ELAHAAGKDPLEFRRALMKNSPKHLAVLNAVAERGGWGQPAPEGRARGLAQIMGFGSYVA
ACAEVSVSAAGELTIHKITAATDPGHAVNPQQIAAQVEGSFVYGLSAALHGECTVAKGRI
EQENFDTY
>A0A7Y9FQ64|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas melonis|TrEMBL
MSRLTVNNQPVEYRLDPATPLLWALRDASNLTGTKYGCGTGHCGACTVDIDGRAMLSCQV
AIGSVEGSFVTTIEGLSHERNHPLQLAFIAANVPQCGFCIPGIIMAAAVLLKHSPDPSEA
DIRSAIRNLCRCGVYPRLVEAIQRAGRATRGEETIPAGARPGIDPADAARVVPALVPPAA
DAGRDKLSER
>A0A5E4T440|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pandoraea iniqua|TrEMBL
MRELRFHGLRFDLRPGATVGDYTGVSRRAFLKTSAVAAGGLMLEMSWPGAVRVAHAEGPA
ATPVVPSAFVRIAPDDTVTIQVNRLDFGQGVQTALPMLVAEELDCDWSKVRSELAPAADV
YKDPLFGIQMTGGSGSVAHSWLQYRRIGASARAMLIAAAAQQWKVPAAQLRTENGVVLGP
NGQRATFGSLAAKAQALPVPTDVKLKDPAAFRLLGKPTGRLDARAKSTGTPMYGMDFKLP
NLKVALVARPPVFGAKVKTFDAKAARAVKGVRDVLEIPDDRGGTAVAVIADGYWQAKTGR
DALNATWDTSGVEHVDTTAQLAKFKELAKTPGVVAIDTDVSKFKGAPKTLVAEYSFPYLA
HAPMEPLNCTVQLSDKGAEVWTGTQFQTVDQAAIAATLGLKPEQVKLHTLMAGGGFGRRA
VPTSDYGVEAAQVAKAWRTAGHREPVKVIWSREDDIHGGYYRPMYVHRAEIGLDAKGNVL
AWNHTIVGQSILQGTPFEKMMVKNGVDSTSVEGVAGTPYAVPLRLSLHSPKANVPVLWWR
SVGNTHTAFVMETLIDELAKNAGQDPVDYRYALIGDKHPRHRAALALAVERSGYGKTKLP
AGQAWGVAVHESFDSVVAYVVVAEVKNGSPRLVSATAAVHCNFAVNPLTVAAQVEGAALM
GLGTTLTGAAITLKDGEVEQSNFHQYTVARLTDMPAISVHIVSSGDAPTGMGEPGLPPLA
PAYANAVFALTGKRLRALPFDLTTA
>A0A0M8JIY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis sp. C-1|TrEMBL
MAGIRDTVRKDKSRLPHVSRRSLLVGATAAGGLAVAWSMWPRDYQPNLTAAPDEHVFNAF
LKIGDNGRISAIVPQCEMGQGVTTLLPQIMADELGADWRTIAVETAPINPLYTNTLLVDE
DSAVFTPRTGVPDFVSDVRSWARREWAVRHAVMLTANSSSVRMFEAPCRAAAAQARALLM
MAAAARWDADWEECDTQDGFVTHGKKRMRFGDVAAAAALLEPPVEPVYRASSADPLYGKE
LTRLDLPAKIDGSANYAGDIRLPDMVFAAIRQGPLGATRLKSIDRKQGLASPGLLHVVTH
ERWVATVARNWWAANRALDRFAPVFETEGTPISTDRIDKALKAALKDDGYRIASEGDVAE
AMEGRQKVAAEYAVAPALHAPIETRSATAAPDRDGLRVWVATQAPAQCRDAIAGATGLAP
ANVTLFPMMAGGSFDACLDHNVAVQAAIIALEVKRPVQLAWSRAEEIMRLPPRAPARAKL
TATLNAAGGIDALVTRIAVPPTNHEVRDRLFDNAPADVAQRAAAGSADAMAVEGAASGYA
IPHRAVDHCPADIGLPTGRWRGNADSYTAFFTECFVDEMAARAGTDALSYRMAMLGNSPL
LARCLLTVTSLGGWEGGLSGTAQGLACHSMRGSHIALMATARQSERGLQVEQLVAVVDAG
RLVNPVIARQQIEGGLVFGLAAAVGATTDYEGGLATARKFGQLGLPDLSQTPQILVEFIE
SDREPGGLGEIGVPVVAPAIANAMYAATGRRIRRIPLSAQPL
>A0A508TYC6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MDRPLLTNRIEGETAMSRRTLLQGAGLLLGFTLTGASTEPVFAAPASQVIENEITGTFAP
NGFIRINPTGAVTLIMPMVEMGQGVYTSLSMLLAEELEVQLDQIQVQHAPPNHALYVNSI
IGIQNTGGSASIRAFWTPLRQAGAVGRNLLIAAAARRWSVDPATCRARNGVVSDATGSKH
LSYGELAEAAANLPVPPAASVKLKGPKDFTLIGTRAKRVDSSIKVDGRALYGIDARLPSM
KVAAIAISPVLGGNAKTVNERAALAVKGVRQVVNIGEAIAVVADHMGAAKKGLEAAAATW
DDGPNGKVNNGGIVRQLEDESKKPGVVARNDGDAEKALAGAAQRLDAVYQAPFLAHAAME
PMNCTVHLQRDRCDIWVGTQAPTITQALVAELTGLPRDAIKIHNHLIGGGFGRRLEADGT
VLAVKIARHVDGPVKVIWSREEDIQHDMYRPYYLDRLSAGLDAAGKPVAWTHRIAGSSIF
ARYYPPYIKDGLDPDAVEAAAEPPYALPNIHVDYVQVEPRGVRTSWWRGVGPTHNVFVVE
SFMDELAHAAEQDPVAYRKGLLGHNPRALAVLSLAAEKAQWGSPLPARHGRGISVQFAYG
SYVSQVAEVEVADDGSVKVKRIVCALDCGMYVNPDTIEAQVQGGTLFGLTAALHGSITFK
DGRVEQSNFDTYLPMRIDEVPVVETHLIRNAEAPGGVGEAPTAIVSAAVTNAIFAATGKR
VRSLPIDTASLKSSS
>A0A5P9GHS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria sp. THAF33|TrEMBL
MALKLNLNGTTHEVDAEPGTPLLWVIRDELKLTGTKFGCGVASCGACTVHVNGEPVRSCQ
TFIEDVEDAEVTTIEAVGDDKIGAAVQQAWVELDVVQCGYCQSGQVMSAVGLLSENPKPS
VQEIDEYMSGNACRCATYQRIRAGIQRASEILEA
>A0A0S4HZ53|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MSPLPNDFALSNFSRRGFLKGVGATSALVLAASWGWQDVFAEEASKKFGADGMPHGAIDD
PKVYVSIAADGTVTVICNRSEMGQGVRTSLTMVVADELDADWAMVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVAECHAQLHKVIHKPSGRELGYG
ALAVAAGALAVPARDSVRLKDPSEFRYIGKEGTKAIDGADIVNGRAIYGADVHFDGMLYA
TIARPAVYGGKVKSLDSSAALKVPGVIKVLQIEGSPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGSIDEAMKSADSTLEASYYLP
HLAQAPMEPMVAIARFKDGVCEAWGPSQAPQVTRTRIGERLGVPFDNVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRL
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGVVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRFQLQGWQKAQA
>A0A5E7DZK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSSNPLSRRGFLKGSAVLGSGLVIAFVIPGAHRFAMGAENQGNVFAPNAFLRISNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGLAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLIDAAAQRFNVAPSAIRTESGVVIAGDNRATYGELADDAGKV
PAPDPASITFKEAKDWKVIGKPTKRLDTPEKITGRARFGMDVQFDGLMTAMVARAPVFGG
SVKSFEGAEALAIPGVHKVVQVPTGVAVIADHYWAAKLGRDALKIDWDLGPNTGLDTQHL
LESFRKLAATPGTSASKAGDAQGALRKAAKTIDVEYSVPYLAHAPMEPLNCTVKITQDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVEVAKAAG
EPVKMVWSREDDIRGGYYRSAFLHQARIGLDAGGMPTAWQHVMVGQSIMEGTAFAATMVK
DGIDKTSVEGVADSPYLAGMANHQVELHSPKTGITVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVEYRCTLLKDHARHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAE
VSQDNLKIRVHRVVCAVDCGIAVNPLSIAAQMESAITFGLGFTLHSKLTFKNGQVVQSNY
HDYQVLRLNEMPVVEVHIVPSTDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E6ZVR8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIEFTVNGERHELVETSPSMPLLWVLRDHLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPVAAAAGHSITTIEGLSATEQHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
DSIRNAMSGNLCRCGTYGRINKAIKRAASAPKEA
>A0A5E7TE85|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVVAASWGWQDAFAEEKEKKFGADGMPHGWVDD
PKVYVSIAADGTVTVICNRSEMGQGVRTSLTMVVADELEADWAMVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAKLHKVVHEPSGRELGYG
ALASAASALPVPARDSLKLKEPAQFRYIGKEGTKAIDGEDIVNGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSFDGSAAMKVPGVVKVLQIESRPLPSEFQPLGGIAVVANNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNIDQALASADSTLEASYYLP
HLSQSPMEPMVAIARFKDGACEAWGPSQAPQVSRERIGERLGLPFDKVTFNVTLLGGGFG
RKSKPDFIIEAAVLAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNIRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFIDELAHKAGQDPLKYQIRLLGPDRQIDPRTLSEEWNYGESPERYPIDTARL
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLVVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLSGWQKAGA
>A0A5E6QMJ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MIEFTVNGERRELAETSPSTPLLWVLRDHLKLTGTKFGCGMGLCGACTVHLDGVAVRSCQ
LPVAAVAGHSITTIEGLSSTEQHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAAVTD
DSIRNAMSGNLCRCGTYGRINKAIKRAANAPKEA
>A0A5E6UUW5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNTPAFIPGEPINLSRRRFLASTAVGALVIGFGLPLGSGRVQAATGAAAERGTQVPAFLE
IRPDGTVRLLSPFMEGGQGTHTAMAQIVGEELDADPATFIVEAAPPGEAYVVMDNGMRIT
GGSMSVRMSYPTMRRLGALARAMLLQAGAEQLGVPVGELTTQPGRVIHAASGRSLGYGEL
AGRALDMPVPDAASITLRDPSQFRWIGKPVKRVDAYDKSTGKALYSIDLKVDDMLHAAVQ
HAPRLGMTVGSLRNQAQVEAMPGVHSVHQLPGAVAVVAERWWHAKRAVEAIQVDWLEPTA
DSKVRAMPADFSSDGFRDFLAAQQGPARDDENEGDVAGALKNAKTQVEATYHNQYVNHAQ
LEPPSALARFNPDGTLDIWLPNQAPDMFRADIAKRTGLAPEQINLHSPLLGGFFGRHFLY
DSASPYPQAIALAKAVGRPVKLIWSREEEFLRDVLRPVAVVKFRAALDADGLPVAIEAVS
ATEGPSEAIAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGNSLND
FFYEAFLDELADQGKRDPYELRLHLLRDNPRLTTLLKAVGELSGGWKRGPYTAEDGTRRA
RGVAMASPFGSHAAVIAEVSIEHGQVKVHHIWEAIDPGSIVNPAIVEAQVNGAVALGLSQ
TLLEEAVYVDGKPRARNYDLYPILPPSRMAQVHVKIIESGEKMGGIGEPPLPAVAPAVVN
AVAQLTGQRVRSLPLSRHTFS
>A0A5E6ZVZ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MTISTMDLSRRGFLKHSATVASGLAIAFYLPSGLAATDPKAPAPPGEFEPNAWVRILPDG
TVKLVVHKHDSGTGTHTALAACVAEELDVNPMTVQVISPEDPFFETYIHPIWKVFSTGGS
TSVSLEYDRLRMAGATARALLISAAAKQWKVSPDTCSTVEGRVVHGASQRSLGYGELVGV
AAHLPAPAKVTLKDPAQFKYIGKLRHKRDAQAKVCGRFKYSIDVVLPDMLVAVIQRTPVV
GAKVLSVDAAAALQVPGVRRVIAVPGRPDVLGGNLEGVAVLADNYWAAQQGRALLKVQWS
DSPLAGFDSDELVKAQAAALDDKGAQRVSAMAAGNVNAQWPGAAKLLEADYRMPYKVQNP
LEPICITAQVKDNAITYWGGVQVPSSALEAAQTVCRIAKANVTINEVVSGGSFGAREAKY
WLFEVAYLAQKAKVPVKLMNSREDEMRSLFMHPATLHRAKGALDAQGRLTALQLNAVSPA
SPEQWEPGYFERPDKMDYSTTEAITAWDFAYRPANLDLVWVKHESDVPSGWYRSVSFIPN
VFAVESFMDELAHGAGQDPLAFRLASMHDRPRHVAVLKSAAERAGWGQPLPEGTALGIAT
NQGYTSFIAVVARLSKKDGVIKVDKLTCVVDCGLAVSPGGVEEQIYGGLMWGLGHALFDR
MDIKQGRVVQSNFHDYRVPRMSDMPAVDILIVDGEPSKPGGVGELGSPSVAPAIANALFS
LTGVRQRSTPLNLG
>A0A240C0I7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia ficaria|TrEMBL
MAISEVQSSREGAIKTLTEHPLMLSVNGENIHTRVMADTPLLLVLRNDLALNGPKYGCGL
GECGACTVLIDGVAARACVIPALGIAGRAVVTLEGLGDREHPHPVQRAFIEEQAAQCGYC
LNGMIMTTKALLDRNPSPSDAEIRQALSGNLCRCGTHIEILRAVQRAIILCRDEETQPDD
>A0A5E7MAA0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVTTIENLHVDPIGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7R4F0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHIDGTPLRACIT
PVTAVAHGQKILTIEGLSLDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAQLG
>A4Z3J2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MNQHVKAAPTMATDLSRRSFLVGTAATGLVLGYAGLADSALAATTPSAFEPTVWYSIAPD
GLVTVTCGKADMGQHIASTMAQIICEELGAAWKDMRVQLASNDPKFNDPVLGAQITGGSW
STMMNFDAMSRAGAAGRIALTEAAATAMGVPAKELVVRDGVVMHPKTKKQMSYAEIVKSG
KITKSFTPDELKAITLKTPDQYTMIGVSVPQLDIPSKTNGTAKYGIDTMLPGMVYGKVVT
PPVRFGATVKSVDDSEAKKVPGFIKAVTLDDKTGSTSGWVVAVANTYANARKAADALKIT
YDNGPYANVSTASILAEAKKLQAQDDSGQFFVKDGDATAALSGAAKVLEAEYTTSINIHA
PLEPMNATAEFKGDILHIYSGNQFATRSGAIAAGAAGIDPKYVVMHQAWLGGGFGRRLDA
DMMVPAVQAAKAVGKPVKVIYSRENDMTMDYSRPLTYQKVKAGLDSDGKLIALSHDVVSA
WPTARWGIPDFLTPSVDKKGPLDSFTVNGADFFYTVPNHHVRAIKNELAHNATPSGQLRS
VAPGWTFWAVESMIDEIAAASGQDPAQFRIALLDGKGKNDGGAQRLRNTLLAAMGLSGYG
AKKLPKGEGMGVACVSSQERATASWTACVAHVAVADNGAVTVKKLTVATDVGTQVHPDNI
RAQVEGAALWGLSLAMYEKATLKDGGIEQTNFDSYTPLRMSQVPEVAIAVIANGEKATGV
GEPAVTVVAPALGNAIYNACGARLRSLPITAEAVKAAMKA
>A0A8I0PHG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces stelliscabiei|TrEMBL
MARQLSRRKFVVYSLAASTLTVAAPLGCDASMAQGVEPPADVARRPSDVLVTGADEEMLV
LEVTKANRVVVRLPRVEVGQGVTTAVAMMIAEELDARLVDVDIPLADARAKGNQFTGGSS
SVSSLYGPARELAALARAKLVTAAARRWHLPARTLKTRNTKVVAPDGRSATFGSLTASAA
RITRPTVSAKPKPASRHKVIGKATTRIDARDIVTGKADYTGDLTVAGAKPTVVARPPTLG
GKAVSVDSQAARAMPGVHAVVKVAGGVAVVAESFHHAFQARDALRITWAPGPLVALSDSA
IRSRLRAAVPRLGTPPPGSAQTEAEFEFAFVGHAPMEVLTAIADVRANRAEIWFSSQSPM
DARDTIATAVGVPESKVKVHVVRGGGSFGRRLNHDAAIEAALISKAARLPVKLMWSRADD
IRHGRMRPASHHRIRASHARGRVVAFTHAVASVSEAYEGQGLSAQGSARGPVRGRVTQAV
ARAADPLPSDSGLYNFGRVTGDWGSIDLAVPLGAWRSVDSGTMRTAEEIVVDEVAKRLGK
DPVAFRRTTLRSKAVKAVLDKVADAGRWGRTMPAGRAQGVAVHEEYGSCVACLVEIDVTD
PKNPRVTRAVMAADVGTAVNPGGLEAQLMGTAIDGISTVLQAGLHIDRGAVRESSYADFR
YARQRHAPLRFEAHIMPSRREPGGAGELGVPAAAGAVANAYARATGTKPRRFPLDF
>A0A6S7CDZ0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter anxifer|TrEMBL
MTQLQINGQAKDIDVPGETPLLWTLRDELGMTGTKFGCGMALCGACTVHMDGAPIRSCIT
PLSAVAGHNITTIEGMEADAVGRAVQQAWIEQNVAQCGYCQAGQIMTAVSLLKATAQPTD
QDIEDAMSGNICRCGTYPRIRAAIQQAAKLLAQGGKQ
>A0A1D3K296|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas veronii 1YdBTEX2|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGAVKGQAVSTIDNLHTDPIGQVVQQAWLDSAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLQGAKA
>A0A0U5EUR5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter senegalensis|TrEMBL
MRKWNRTQGEGLSFPTRRALLGSVLAGGGSFLLSAFVPGLPLIRASKAQDAVTGIVFSPN
AFIRITSQGSVTLIMRHAEMGQGIYTGISMLLAEELEVGLDQVSVEAAPADPAYVDSVAG
EEETGGSSSTRDSWVPLREAGAAARMMLIAAAAEQWGVPASACTARHGTVFHQASGRSTS
YGALAEAAARQPVPKKITLKSPTDFTVIGTSPRRLDTKAKTNGSARFGIDVQIPGMKIGC
IKACPVKGGHLTGYNRAAALAVPGVEDVLTLPDAIAVIASHMWAALKGQEAAAPAWDYGP
NAHIATTDIVARMKAASEQSGVTALKTGNAEEALKRAHTRIEAVYELPFLAHAALEPINT
TLHIRPDGADVWVGTQVPGRARQEVADATGLPPESIAVHNHLIGGGFGRRLDSNSIGQAA
RFAKQVSYPVKLIWTREEDITQDQFRPYYYDRISAGLAADGTISGWHHRTTGSAVTARWY
PEGMQNGLDPDAVEGAAQTPYAMADQLVEFVRDEPDAVTTLWWRGVGPTHNVFVVESMID
ELAHTSGQDPLALRKKLAAHQPRAIKVLDEVAKQSGWGRALPVGHGLGIALHYSFQTWAA
TVLEVAVEKSGQIRLIRVDSAVDCGPIVFPDGVVAQIQGGLIFGLTMALYNEITLKNGQV
EQSNFHNYRMMRLNEAPDIRVHLVPDPDAEIGGIGEVGTVAAAPALANALFAATGKRLRR
IPFAKQFSKLDAAL
>A0A1S7RET9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Agrobacterium tumefaciens str. CFBP 5621|TrEMBL
MSYTLSVNGRSHDVDEDGETPLLWVLRDNLSLTGTKYGCGAAQCGACTVHLDGEPTRSCA
IPLKSAVSAQIRTIEGMAGAEAAALRDAWVKLDVPQCGFCQSGQIMSAIALLQYIKKPTD
EEIDVAMSGNLCRCATYNRIRAAIHHAAAMLGTAT
>Q7NXF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)|TrEMBL
MTTTGVSRRGFLKMSGAVGGALCLGFVLNERGGKAEAAEAKSAIPAPNAFVRIEKDGGVT
IVSNKSEMGQGIYTSLAMLIAEELECDWNRIKVVSAPAAPVYVHTAFHIQITGGSTSTLS
SYDQYRKIGAAARDMLIAAAAQRWRVPASQCRAENSRVFNNANGASLGYGELTEAAGKLP
VPDTVELKPRHRWKLLGTRVHRVDGDEKLDGRAQFAMDVRLPGMLTALVKRCPSYGGKPK
GFNADAARAVPGVRDVFAISNGVAVLADGFWPAKKARDLLTVDWDHGPNAGLDSAKLRAD
YRARAATPGQTYRSEGDAEAALAGAAKKLEAWYEVPYLSHSPMEPLNCVVWLKPGSCQIW
SGTQSQTLDAGMAAAMAGLKPEQVSLHTTLLGGGFGRRAVPAGADWLKEAMEVAKRHGQG
APIRLMWTRDDDLAGAYYRPMWLDRVRGGIAADGKPAAWLQTGVGQSIIAGTPFAPMMIK
NGIDAVSVEGTDDMPYALPAVALDLHTAQTPLPVLWWRSVGHSHSAFTKESYIDELARLA
RQDPVAYRLALLGKAPREQGVLREAARMAGWGRKLPKGHGLGAAVHSSFGSHVAQVVEVS
LKGKELKVEHVWCAIDCGVVVNPDQVAAQMEGGILFGLSAALFGEITFKDGEVEQKNFDG
YPIVRMFQAPKVDVSIVASEEAPGGTGEPAVPVVAPALANAIHAASGKRLRELPLSRHGY
QAV
>A0A165PL44|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. W74|TrEMBL
MRLIVNGSEFDVPDSWQDETLLMVLREQLGFVGPKLGCGQGECGACTVHINGEAVRSCSI
YAIDVQSDSITTIEGLASADGVLHPVQQAWLDERVAQCGYCQAGQIMQAAALLNEEPNPD
DQTIIDHMSNNLCRCGTYKRINLAIKNASQVMQTRKAS
>A0A165MYJ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. W74|TrEMBL
MSRLGKYTRRAFLGLGVAAAGGLAVGFYFYQKPYANPLDAKKAEGETPFNPYVMIDQDNT
ITIIAPRAEMGQGVHTTLAALVAEELEVPLEQVVVEHGPSSPAYFNAAMLEESTPFPFYD
ESVLAELARGSMKIVAKFLGLNMTGGSSSTTDAFVKMREAGYAAKFVLLKAAAEHFGTSE
DNLTLANGTITNTASGKSVTYGELASKAVAVSPPSEMKLKKASDWKILGKSQKRVELKDK
VTGGRIFGIDVQLPNMLYGTVRMAPRKGVSLKSYDKTATLAIPGVKDVVEIRTITGEGLG
VVADNTWAAFKGAEALQIEWDDPLSLQNSDQMWSALESALTQEATFELGGTGSDAEVFTS
IPESEAVSAQYRVPFLAHATMEPMNATAQHDESTIRVWTGTQAPGLIQSVVSSHFDMDSA
DIDVTTTRLGGGFGRRLEVDFALYAAVIAKATAPNPVKVTWTREEDTQHDTYRPMAIGQF
KGQVTPDGTLKTMDMQVASPSIIQSVMPRIFPGISPAGPDNTVLDGAFNQPLDVENIRCQ
AHVADLQVPIGFWRSVGNSVNGFFHESFMDEAAHKAGKDPLEFRLAHLTSDEFRPAREAL
KRVAEMSGWGTPLPAGKGRGIAHVLSFGTWTAQVVQVDVTDNTVIIEEVWAVADPGIVLD
PGIFKDQIMSGINFGLSQALGQEITWVDGEIEQANFDTFDAMRMYQAPKITIELLENSPR
MGGAGEPGTPPSTPALANAIFAATGKRIRQMPLSNEIDFI
>G0L7V1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zobellia galactanivorans (strain DSM 12802 / CCUG 47099 / CIP 106680 / NCIMB 13871 / Dsij)|TrEMBL
MSTPSIPFSRRNFLRTSSLASGGLLIGFNLFTACKSDVKPPVDLADLNYNDFNAFIKIAK
NGAVTIFSPNPEIGQGVKTAMPMIIAEELDVAWDNVYVQQGVLDTKNYTRQIAGGSQSIR
FGWDALRQTGATAKQMLVNAAAARWGVDASELSVSEGIITNKAGETLSYGDVVEEAAALE
VPENVTLKEPKDYKIIGTDQRNVDIDKIITGQPLYGMDYKVEGMVYAAVLRPPAFGQELV
SFDATEAKAIPGVIDVIQIGDKAKALLEKDKVNWTAQLSGSGKVVVLAKTTWDAFKGKKA
IKATWSDATPLESTEFHDEKLNALLDGKDFVTMRKDGDVNKAFAQADKVLERTYESPFLP
HNCMEPMNFFAHVTDEKIHLVGPVQTPEDAANTVAELLGRDVADIHLEMTRMGGGFGRRL
YGDFVYEAAEISDAIRKPVKMVSSREDDMSTGVYRPSIKYRIKAAIKDGQLTGYQLKEAA
INGNMYGLIPNFFPAGAVENYQVDVANYKSNITTGAWRAPYTNFLAYAEQSFFDELAEEM
EVDKIKLRLDLLEKVKGTTDERIEYSPERMQKVIKMAVDKSGWGKQPQGTYQGFVAYYCH
NTHVAEVADVVIEKGLPVVKKVTCVVDCGIVINPLGALNQIEGGIVDGIGHSMYGSFGFE
NGQPTAKNFDKYRLGRMKDAAAVETYLVQNELSPTGLGEPTLPPAGGAVANALKAATGKR
VYKQPFIEQEELWQAKQEEILG
>A0A7W5X8W5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK602|TrEMBL
MKLQINNQTYQVESGDDTPLLWVIRDELGLTGTKYGCGLAQCGACSVLVDGEIVRSCVTP
VESVVGRHITTIEAIEDDPIGKKVVAAWVEHQVPQCGYCQSGQVMAATALLKQTAKPSEE
DIAAAMINLCRCGTYNSIKAAVQDLSGQKVQTL
>C6WH60|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)|TrEMBL
MIGRRGFLAAVGLTVALPAPAFASGAGLVPNVLVRLDARGRVTTTVPRPDTGQGVRTVVA
MLVAEELAVPLASVAVEQAPGDTARYGRQGIGNSTSVRQLADPVRRAAATARALLVTAAA
QRWGVPVAECAARDGHVRHRGRALPYAALVQAASELDPATVAAPLTPRADWKVLGKRAGR
VDARDIVTGRARYGLDVALPGLLTAVVARPPWLGARLAAHDDAQALAVPGVLTTVALDGV
AGAQGGVAVVARSASAALAGRAALTCEWTGGTPDADSREWLAQLVAALPQDPPPANGHTA
TYELPLLAHAPMEPMNATADARPDLVRLWAPTQDPGGLRDTLTRALGVPVEVEPTLSGGA
FGRRIEDDYALEAIACSREAGAPVKVLWTREDDTRHDSYRPMSAHRLTAELGPDGLPVRR
AHRVATWGLTVLPFFGTPQLVLASGDHFPYAVPGEVTATVLPAPLRTGFWRAVYAGQFAY
AEECFLSALAQRGGWDQVEYRRRLLADQPRVLRVLDAAAARVRFRPGPGRALGVACHLEY
GSAIAVLAEVDARGGKPVVRKVTAAVDVGQALHPSGVRAQVEGGVLDAISTVLGARITVR
EGRVEQSSFRDYAWARIDAAPEFDVVLVDSDAPLGGMGELAYPPAAAAVASAVAQATGRP
VTGMPVHSEVG
>A0A085GMW8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ewingella americana ATCC 33852|TrEMBL
MNTLEITRRRLLQSGGVVMVSSLFVSPLSALASAPTTSKVTDIPLDRVNSFIAMSADGKV
TAFNGHVDLGTGVRTSLAQIVADEIGVRFEDVTMILGDTNRTPNQGPTIASSTLQVSAVP
LRQAAAQVREMLTALAAKAIKLPAEQLRAEQGFVFVEAHPAKRLSYAQLAEGQDINLPLD
TSVQLKSVKESQYVGKPVARVDIPAKVTGQLTYVHDMRLPGMLHGRVVRPPYAGADSSAP
LGDSLISVDKASIAHLPGIVEVVVIKDFIGIVAEREEQAIAAMRQLKVEWKKWAGLPDLS
LDKLHDTLAATPKTDRMLRNDAGTDEALAGLHIHADADYVWPYHLHASIGPSCAVADVTA
EKAEVWSGTQNPHDLRKDLAKLLDRVPEQVHINRMEASGCYGRNCADDVSADALLLSQAV
DKPVRVQLMREQESGWEPKGTGQLIRVRGGLDKQLQVAAYELKTSYPSNNAVTLPLVLTG
KVPNNADVQQMGDRTAIPQYEYPHMRVLSQDAAPIVRASWMRGVSALPNVFAHESWIDEM
AYLAGQDPIAYRLQYLKDDRAIKLIAALKKQCNWQDGPAHHKPAPANQEVVTGRGFAYAR
YFHSKFPGFGAAWAAWVCDLSVNRKTGQIKIDKIFVAHDCGRMINPAGVKHQVHGNIIQS
TSRVLKEFATFDGAGTTSLEWGGYPILRFDELPQVDIQLLDYPDEPPMGAGESASVPSAA
AVGNALFDALGVRMREVPFTPERVLKTLESAAQVKEDKA
>A0A7Y9UHL9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. IAR9|TrEMBL
MIKVKINGQEQSWDGDPDLPLLWFLRDEAGLTGTKYGCGQALCGSCTVIVDKQAVRACIT
SVNDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLMDNPKPSHD
QIRESMSGNICRCGCYQRIENAVHLASTGV
>A0A841E186|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kribbella solani|TrEMBL
MPTHTFKLNGKQISVDAEDSVRLLWVLRDLLGVTGPKYGCALNVCKSCTSHINGKAFNPC
SVPVKDIAPTDEITTIEGLPDTVGKDLHPMQQAWLKYDVAQCGYCQPGQIMAAVALVKKV
RKEEREITDADLDELRNICRCGTYTRIREAVKAGAEHMGA
>F4L4N3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MTPNSNSRREFLRLSSLSGLGLVLGVSSFAKNSSLVKLTAEAIQLEINPFIIIDNLGNIT
LVNPRPDMGQGSTQAVPSLLAEELEVSLEKVKLIQSDGKSKYGSQTAGGSSSVRELWEPL
RKAGAAAREMLTETAAKRWGVPVANCYAEDARIHLKNSDKSFSYGELADEAAKLPVPKEP
KLKDPKDFKIIGKVKPRLDVPARVTGKAVFGLDVDVPGMVYAAILHAPAIHGKIVSIDDA
AAKKIPGVIRVMKAERPMPHRTSEAVAVIASNWWAAMKGKKALNVTWDNAGLDKMNTDAY
FAKGREAAKAEGINFEEKGDIDQALTHSEKTLEAVYETPFLAHAPIEPENAIAHVKDNGD
VEIWAPIQGPDWALRDVAGYLKIKPEQIKINVFLLGGAFGRKAYHDFLLEACFLSKELKK
PVKVIWTREDDITQGPYRPGMLSAMKGAVNGKKIAAFHHHAIGESISRQVFNGLQDHQVD
DWISGELSAENHKYEIPTWKLSWSNVKTDIPVVWWRSVYASNFAFGQECFMDELALAAGQ
DPIEARLALLKDERFRKVLEVIAEKSNWKENLPAGQGRGVAVFKSFGSISACCVTVSKQS
GGGVKIEKVVSVIDCGWHVNPDNVKAQTEGNIVMGLTAAIKPGITYANGMAQQSNFHDYP
IMRINETPKMDIHIVNSGAQPGGVGEPGLPPVAPALANAIFAATGKRLRKLPIDLNEV
>A0A375HL56|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLKLKINGKRHAVEAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAARACI
TPVGSVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLKDNPSPRP
EDIRAGITNLCRCGTYPRVERAILRAATAQNAGDPKGRASS
>A0A1I7E274|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas marincola|TrEMBL
MELRINQKTYKVDAEADTPLLWVIRDDLGMTGTKYGCGLAQCGACSVLVDGNVTRSCVTP
VASVVGREVTTIEAIESDEVGKQVVTAWVERQVAQCGYCQSGQVMAATALLKRNPSPSTA
QIQAAMVNLCRCGTYNAINAAVHDLANNIGSSAAPNEEGV
>A0A7Y9W718|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MGSLNINGRAVAVQAEPDMPLLWVLRAELGMTGTKFGCGVGICGACTVHLDGKASLSCQT
LMSSLHTQKITTIEGVQGAEAQALKAAWIDLDVVQCGYCQSAQLMAACALLKQKPNPTDA
DIDAAMSNIVCRCGTYPRVRAAIHQAAAKRRSV
>A0A1S9GYR3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium laguerreae|TrEMBL
MVELVVNGRSLSVDAEVDKPLLWVLREDLGLLGPKYGCGIAQCGACRVLIDGKSTPSCIT
PVGSIAGASVVTVEGLAQANGALSAVQQAWLDEQVPQCGFCQPGFIVATTALLEAKPRPT
DADIDEAITNICRCGTYPRIRRAIHRAAAMLAER
>A0A853T6Q5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. HH102|TrEMBL
MAAQSSPSRRRFLLGGLGLGVAGVGALVLGWGVLPPRQRLHGSAPLPLQDGAVALNGWLA
IGTDGTVTLAMPRSEMGQGVHTALPMLVAEELDVPLASVKLIQAPNDKIFGNVAMLKDSL
PFHPDDQGRVKALAQWTVAKAARELGVIVTGGSSSVKDGWGPMREAGASARAMLLQAAAA
LWQVPAAQCRTENGDVLHPDGRRASYASLAQRAAAIDPGTPVLKLPKDFKLIGQPAPRRD
TPSKVNGSARFGIDARPPGMLYAALHLPPRLGDTLSAFDAAPILAMPGVKKVLDLTPQLA
QRSVSCAAVVADTWWRARQAAAALPTQWKAGPQANLSSAGVYAEFARLLDTEAGYAYHAS
GEVESKAVQGLRSVKAEYRAPFLAHAAMEPVNCTAQVKNGKVMLWVSTQAPGIAVDVAAK
VAGVDAQDVSIEVLLLGGGFGRRLEVDMVAQAVAIALQCDGAPVQLVWTREQDTKHDMYR
PAALARFAARLDEHGRIASWDNKSVSGSITHQYLQRNFGLPGAGPDKTTAEGEFDMPYEI
ANQRIAHVIADSAVPVGYWRSVGHSHNAFFKESFIDELAHAAGQDGIAFRRAMLTQHPRH
LAVLDAAVARAGSAPPGHAHGVALHQSFGSIVAQVAQVSVENGEIRVQRVVCAIDCGIAV
NPNIIAQQMESAVLFGLSAALGGEITFQEGKVEQGNFHDYPVLRMGQTPEVETIIIASAE
HPEGVGEPGTPPIAPAVANAVFSLTGKRLRSLPLRLA
>A0A853SQV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. HH102|TrEMBL
MRIEWLNQEALQHGAVTLGTALASAPVADGVSRRGFMKAGAAAGGGLMLGFFLPGAGKLA
QAADAAPAKPVYAPNAFLHIAPDNTVTVQVNRLEFGQGVQTSLPMLIAEELDADWSLVHG
ALAPAGEQYKDAAYGMQMTGGSGSIAHSFTQYREIGAKARAMLVGAAAAQWKVNPDQVRA
AKGVLYGPGGQKATYGEFADAAMRQPLPATVKLKDPREFSIIGKPVKRLDAAAKSTGKQQ
FGIDFKPPGAKVAMVARPPVFGAKVAKFDASKAKAIKGVLEVLEVKTDRGGSGVAVIADG
YWPAKQGRDALVIEWDSSAVEKVSSDQQLAAFKALARTPGTVARAFDVSALAKAPKKIEA
VYEFPYLAHAPMEPLNCVVDLQADKCTMWVGSQFQTGDQAAIAATSGLKPEQVTLHTMMA
GGGFGRRAVPSSDYVVEAVNVAKAYRAAGKSGPLKLMWSREDDIKGGYYRPSHVHRAQIG
LDAKGKILAWDHTIVGQSIMAGTPFEAFMVKNGVDGTMVEGMGEPYTLPMKLSVHTAKAN
VPVLWWRSVGSTHTAFVMETLIDEAAHVAKMDPVAYRKQLIDAKHTRHIAALDLAVAKSG
YGKKKLPKGQAWGVAMHESFNSVVAYVVTASVVEGAPKLHQVWAGVHCNLAVNPLTIEAQ
VQGAALMALGMTIPGAAITLKDGVVEQQNFGDYPVPRMPDMPVIEVHLVPSGDAPTGMGE
PGVPPLAPAFANALFALTGKRLRKLPFDLAAA
>A0A177YVP9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MELRINQKTYQVEADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREVTTIEAIEADPVGQRVVTAWVDHQVAQCGYCQSGQVMAATALLKHTPKPSAE
QIDAAMVNLCRCGTYNAIHAAMHDLAQGEQA
>A0A4Q4K1M0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium elkanii|TrEMBL
MTLIDNLSERAADLSRRNFLRAGAIAGGGLLLSVSLPFAGRESEAAASDGFAPNAFVRIG
GDGKVVLTMPYVEMGQGTYTSIPMLIAEELEIGLTQVRLEHAPPSDKLYANPLLGVQATG
NSNAMRGAWQPMRKAGATAKAMLVAAAAKRWNVEPGTCRAENGEVHHAASGRKLGYGELA
TDAAQMPVPENVTLKSPSEFKLIGTPAKRLDTPSKINGTAVYGIDARPPGVKIATLAQSP
VFGGRVKRVDDAAAKAVNGVRQIVTLDDAVAVVADHMGAAKKGLAALTIEWDEGAHAKLA
TSDIARELETATTKPGAVAQNIGDADKAMAGAATKVEATYQLPFLAHATMEPMNCTVHVR
PDGCEIWVGSQALSRAQAVAAKVLNMPPEKVVVHNHLLGGGFGRRLEVDGVIRAVQIAKQ
VDAPVKLVWTREEDIQHDMYRPYWCDRIAVGLDASGKPVAWNNRFAGSSVLARWAPPAFR
NGLDPDTTEGAIDLVYDIPNFHVEYVRVEPPGIPTAFWRSVGPSHNVFVTESVIDELAAA
AKQDPVDYRRALLGKSPRAKAALELAAAKAGWGGKLPAGRGRGVSLQFVFGSYLAQVAEV
EVARDGSVRVHRVVCAMDCGTVVNPDTVQAQLQSGINFGVTAALYGEITLKDGRVEQSNF
DSYQMLRIDQAPAIEVHIVPSTEPPGGMGETGTSGIVPAISNAIFAATGKRLRKMPVDPA
VLKQT
>A0A0G9MR49|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantiacibacter gangjinensis|TrEMBL
MQVSRRGLLAGAAVGGGVLVAWAFLPRDFASPLEPGEGETAVDAWLKIASDGVVTVAVPQ
LEMGQGVTTLLPQIVAMEVGADWRQVAVEPAPVSSAYANIPLAAHWAPLWRPAVPSLADQ
ADDWALQSWARDNRFTVTAKGTTLAAYEQSCREAGAAARSMLAQAAAERWDVPWEECRAE
NGVIYHNENAASFAELAVEAGEFSPPDPPPLQSEAPAEAGPLEGMAEREVPLQWPRLDLP
SKVDGGHVFAGDVRLPGMVFASVRHGPHDESELADFDAGRAAGQRGLVQLVRGKRWLAAI
AENWWAAEQALQEIAPRFATERPVQSAQIVEALDDALRNGPARIVEKRGDGAEDYAHDFA
LRYDIAPGLHATMETTTATARLAVGTLELWLATQAPEAARQAAAKAIGLSASDVILYPVA
AGGSFDRRLDNQIAIEAALIAREVARPVQVTWSRWDEHAASYPRPPAAGLMAAETDDSGN
IRTLRARLASPPTMREFGRRLFDNEVSWRAIDELEGEEGVFAVEGLAPPYTIANVSVEHA
PVTILLPTAPMRGGADGYTCFMRESFIDELAARHEREPMSYRIAMLGQDALLADCLQRAA
RLASWDGGIAGSGQGIACHRMDFGDAAGRIAVVAEASAGEGGVRIRRIFAAANIGRVVNR
DIALQQLEGGIVFGLGMALGCSTEYANGRPTHERLAALAIPTLADCPQVEVELVESDAPP
FDPGEIGVPAVAPAIANAFFSATGLRLRRLPLLSALV
>A0A143GKA4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas yamanorum|TrEMBL
MELRINQQTHQVDAEPDTPLLWVIRDNLGMTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VSGVVGREITTIEAIESDDVGKRVVATWVEYQVAQCGYCQSGQVMAATALLKQTPKPTDA
QIDAAMVNLCRCGTYNAIHAAVHDLAKGEA
>A0A1X6YPE0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius halotolerans|TrEMBL
MKLTVDGTEHELDIETDMPLLWVLRDELGLTGVKYGCGIAECGACMVHIDGQAVHSCQTL
VGDVWGEVTTIHGLAAPGTLHAVQAAWVKHQVAQCGYCQSGQIMQAAALLAQTPDPTDQE
IDDAMSMNLCRCGTYPRIRAAVRTAARTLQEGTQ
>A0A4P0UJI2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MKRSTLDDLVIGNLSRRGFLKGVGATGVLLVAANWGWRDALAAEQKAFGADAMPHGWVDN
PKIYVSIDKDGTVGIVCNRSEMGQGVRTSLAMVVADELEADWSRVRVIQAPGDEARYGNQ
DTDGSRSMRHWFEPMRRCGAAARQMLEQAAANQWKVPLDECRAEQNRVLHAPSGRSLSFG
ELAEAAAGLDVPARDKLVLKKPEQFRYIGKDVARAIDGADIVNGRAGFGFDARFDDMLYA
VVARPPVYGGKLKRYDAAAALKVPGVLKVIEIESRPIPSEFQPLGGVAVVARNTWAAIKG
REALVLEWDAGVNGGYDSAAYRKQLEEAARKPGKVVRDSGDAAALFARGGDIVEAEYYLP
HLAQAPMEPPVSTAWYKDGACEVWAPTQAPQVTRERIAERLELPFDKVTVNVTLLGGGFG
RKSKPDYVLEAAILAKEFPGRHLRVQWTREDDLHFSYFHTVSVERLQAVLGADGLPQAWL
HRSVAPSITALFGPDSKHQGAFELGMGLTNLPFAIPNVRLENPEAPAHTRVGWFRSVSNI
PHAFAIQSFVGELAAKAGQDPKDYLLKLLGPARRIDTAELGDSWNYGESPQRYPLDVGRL
RGVIEEAARQSGWAASCPGAGRGESPRTTASSPTWRW
>A0A0E3V076|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polynucleobacter duraquae|TrEMBL
MTKTIHTATTNTSRRHFIVGTSAIATGLAIGFDLTLISSANAAMGSGTTAMTPLSPSEIG
VWVEVKPNDDIVVRIVRSEMGQGTITGLAQMVAEELQCDWKKVSYDYPTPAENLKRNKVW
GSYSTGGSRGIRTSEQYVRKGGAAARMMLIQAAATQWGVPVSECVAKDSVITHIPSGRKT
TFGKVSIAASKLEVPKDIPLKDPKDWTVIGKSVNRIDGTADKVTGRQVYAIDLKLPGMLV
ATIQESPVFGGKVKTFDASKASSMKGVKKVVQVSDSSIAVIADTYWQAKMGMDAVSVNWD
NGANGDVSSASIKKMLEGGLTANDTFVGNSNGDAKEAIAKASKTIEATYFYPFLNHATLE
PQTATAKWTADSCEAWVPTQDGEASLAAVIAASGLPAEKCNVYKVNLGGGFGRRGAFQDY
TTQAVNIAKQMPGTPIKLIWSRSEDMTQGRYHPVTMCKMTAAIDDKKNITGLDMRISSQS
ILASVRPAVVAANKGKDPVVFQGLDVAGEHGITYSFPNLMVDHAMRNTHVPPGFWRGVNV
NQNAIFLETFMDEMAEATGMDAVEFRRKHMEKFPRAVAVLNAVADGIGWTKPAKPGVFRG
LAQMRSFGSYVAAACEVTVTNGNEVEILRMVAATDPGYAVNPAQIARQVSGSFVYGLSAL
FEEEITIEKGAVVQKNFDTFNSIRLSQMPPVETIIIQGGGKEWGGVGEPTIAVAAPAVLN
AIYRATGKRYRTIPLKNSGIKLV
>F4C2U8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobacterium sp. (strain 21)|TrEMBL
MISFTVNNKTYQLDLDPNMPLLWALRDVVGLTGTKYGCGVAQCGACVVHLDGEAIRSCIT
KLSRVAGKHVTTIEGLSEKNDHPLQQAWVAVDVPQCGYCHSGQIMSAAVLLREKPNPSDE
DIDNAMAGNICRCGTYLRIRKAIHIAAELQQKTSER
>A0A7Y9YG89|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides marinus|TrEMBL
MHESSTTARSTTGHVDSPGGTGEVASSPPGLDRRRFVGYVLGGATLVTAADLTLGRVPAR
GAVPSLPQIPEIYDLEDLQTDAALATSQLITVTIREDGTAAFELPRMEVGQGIVTSTAMI
LAEELDLPMRKIEVTLAPARPELLMNQLTGGSNTTVSTFTPIRVAAAIARQQLLEAAAAR
LGTDADRLSTISGAVVDGAGNAIPYGELAADAASQVVKQVGVTLRPREEYRVIGTGRKRT
DAKAAVTGQKDFSTDLQVKGAKPTMVCRPPTHRGRPVRLRNEKQILKMKGVTHVAQIPTG
IAVRAKTFGQCIDAIRKMDVEWDLGDLAGENDESILAGLRAAELPMAVPQVPILAEQVDL
DFEFMFRSSAALEPYAAIADVREDRAEIWAGLKVPILAQQNIAQELGMTQDQVKVNVVTG
GGSFGHKLFSDHAIEAAQISQAMGKPVKLMWHRADEPRQGRLHPMCTSRVRATMLAGQVL
SFEQRHTSVVTDFSHGLGEIITSTIDEAPTEVGRYLGGLGFAETIFTLTQELPYNLGAIT
QLLMETDQRFSTGSMRNIYSPDVCVAAELTMDEIARRMGKDPLELRLELCRNDRVRAAIE
AVAKRGNWGRSMPKGTAQGIAVHKEYKGCTAVLVEIDCRPRTVNRKVRNAVTGPRVTKAV
IAVDAGLVINPIGLEAQMQGGFMDGLALTLTSSCHLEDGRFLEASWDNYFYTRQWNVPPE
MEVIVMDPDVDQPGGAGEAAVGSSAAAVACAYARATGSVPTRFPINHDTISFKPKSFIPP
VPKSPTNGLKFTY
>A0A0H2XVZ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cenocepacia (strain AU 1054)|TrEMBL
MSRGLIEAGRATAGVSRRSFLKLGMSLGAAAGGGLLLGFSLPAAGDDARRSVIGGDAAEP
AQPGVFAPNAFVQIDRAGKVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
EKLFLDPLLGGQLTGGSTSVRYAWDPLRQAGATARTLLVSAAAKQWNVDPASCRAANGEV
QHPPSGRRASYGQLADAAAKLPVPKDVVLKKPADFKLIGTPAKRLDSPEKVDGTAQFGLD
VRLPGMLYAVIVNSPVFGGTVASVDDTAARKIPGVRQVVRVDNAVAVVGDHTWAAKRGAS
ALVVKWNEGAGAKVSTKDLFADLAQAAANGKGAVARKEGDVGKAFANAKTRVDAVYEQPL
LAHATMEPVNCTVHVRGDGCEIWVGTQVPTRARDTAQQLTGLSPDKIVVHNHLLGGGFGR
RLETDMIGQAVKVGKQVNAPVKVIWTREEDVQHDMYRPCYHDAISAGLDANGKPVAWQHR
IVGSSILARFAPPAVKDGVDPDAVEVAAELPYDLPNQLVDYVRQEPRHVPTAFWRGVGPT
RSTFVVESFIDELAAQTKTDPVQYRRALLDKTPRARNVLDVATKAAGWGTSLPKGQGRGV
SVMHAFGSFFSIVIDVAVDGGEVQVKRAVCAVDCGMYVNPNTIEAQVQGGIIFGITGALY
GEITIEDGRVVQTNFNDYRMMRINEVPPIEVHLVKSGEAPGGIGEPGTAATAAALSNAIF
AATGTRLRKLPVGNQLKTA
>A0A446CD74|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter agilis|TrEMBL
MPEARHRLPCPPPKDSAMTQLQINGQAKDVDVPGETPLLWTLRDELGMTGTKFGCGMALC
GACTVHMDGAPIRSCVTPLSAVAGHDITTIEGIEADAVGRAVQQAWIEQNVAQCGYCQAG
QIMTAVSLLKTTPQPTDQEIEDAMSGNICRCGTYPRIRAAIQQAAKRLAQGGKQ
>Q13R04|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia xenovorans (strain LB400)|TrEMBL
MTTGITITVNGRQHAVQADPETPLVYVLRNELGLYATKFGCGVAQCGVCSVLLDGQEIRS
CIMPVSMAAGHEITTLEGLGELWEQRKRTPGTSLHREPETTDLHPIQEAWIKLQVPQCGY
CQSGMMIQAVSLLNTNPQPTRSDIVASMQGHICRCGTHMRIISAIEQAADHMSKEG
>A0A2R8BNW0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Defluviimonas aquaemixtae|TrEMBL
MGRLRTIARRGFLIGSVAIAGGVAFGVYAVRRAPENPLIEDRAEGEAVFNPWVKIDANGI
TLIGPHADLGQGVASSQAALIAEELDVDFGQFSTSFGRPSAAYWNTAMADEGVPFKSTDE
SFAAESIRSVMGGVVKLIGLQGTGGSTTIPDSFDKLRQAGASARETLKLAASKRSGVPVD
EIKTASAQVILPDGTAIPYTELAAEAAGIEPVQNAPLRDPSEWRLIGQPMERIDVVAKST
GTQTYGIDLATDDMVHAALRVNPRKGGGIKGYDPSAALAMPGVRRVLDITGGAAVIADNT
WTAIRAANAIEFDWGPAPYPAEQAQHWETLAASFSDDLLDRKWRDDGDIEAALADAEVIE
AEYRSPYVAHAPLEPLNAIVRVTDEGVEVWTGHQVPRQLQVLVAALTGHEPGQVTFHNQY
AGGSFGHRLEFEYLKQAAEIANQMRGTAVKLTYSREEDFAHDFPRHIAMGRGRGVVANGR
VEGIDLSIAAPSVIASQLGRANIPVPGPDAQIAAGSWNNPYALPHFRMRAYRVPELAPVS
SWRSVGAAGAGFFFDSFLDELIHAAGADPMEERIRLMGHDVSRKVLEAVAEMSSWGGELA
PGKGRGVAFVESFGVPVAEVVEVTTVDAGVRIDKVWVACDVGTIVDPVNFENLVQGGVVW
GLGHAMNSEITYSDGMAEQTNYHAHEGMRLYQCPEIIVRGLENGHKVRGIGEPPVPPAAP
ALANAIFAATGKRIREMPFNKHIRFA
>A0A840R6V0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zhongshania antarctica|TrEMBL
MTTFTLNGKKISSSAPGDTPLLWVIRDEFGLKGTKFGCGIAMCGACTVHMNGNPMRSCSL
PLAAVSNADIRTIEGLEARHPLQKTWVEEQVPQCGYCQSGQIMQAAALLADKANPTDEEI
VQYMSGNLCRCMSYVRIKRAIKSAAQSSDGVIQIYDPKRQTVVDNSLSAQTDEQGVS
>A0A2Z2NWV6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Granulosicoccus antarcticus IMCC3135|TrEMBL
MSITLKINGESRQVEADADTPLLWVIRDELNLTGTKFGCGVASCGACTVHLNGKPQRSCV
FPIGAVGDSEVTTIEVVDTPQAKAVQSAWQELDVVQCGYCQSGQIMSAIGLLSENAKPTD
EDIDTFMQGNACRCATYHRIRAAIHRASDILEA
>A0A3M2RA94|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter litoralis|TrEMBL
MALSLTVNGQHYSLDVELDTPLLWVLRDELKLKGTKFGCGAGLCGACTVHVNGQPTRSCS
TPVEYLDGAEITTIEGLSENGELHPLQKAWVAEGVPQCGYCQSGQIMTAAHLLANTPSPS
RDEIVTAMSGNLCRCGTYSRIVAAVESVVDGVGHYEPEQGEA
>A0A1V0PUY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MIKLTVNGTEHEVDIAPATPLLWVLRDVLGLTGAKYGCGIGQCGACTVHVDGVAERSCQI
PVGDLWGAVTTIEGLGTPDAPHPVQAAWIEHQVAQCGYCQSGQIMTAAALLAEVPEPDEA
AIADALWNNLCRCGTYPRIKTAVRSAAQKLKEG
>A0A0M6XM34|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia rubra|TrEMBL
MQIIVNGRPHDVDAEPDMPLLWLLRDELGLHGTRYGCGIAACGACTVHLDGEAVPSCQIA
VGDVGDARITTIEGLGQPDAPHPVQQAWIEEQVAQCGYCQSGQIMQAASLLARTPDPTDA
QIDDAMSGNLCRCASYPRIRAAIRRAAAAGGV
>A0A1V0Q1Z4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodovulum sp. P5|TrEMBL
MSFRGSHVACVAEVRDNRVAGLWLAADVGRIIHRDNVVAQIMGGMVWGLSMALVEGLDFA
NGAARAESIWDYPVIGADALPPLDIALIEPDPEAAPCGVGEIGVPTVIPAVCNAFECATG
RVFDRLPLEVS
>A0A7X0JDD3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas endophytica|TrEMBL
MAEITRRRLLVSGGIGAGLVVAWAVWPRAYLPNLAAAPDERVFNAFLKIARDGKIIVAVP
QCEHGQGVFTTLPQIVADELGADWRTVGVEAAPVSPLYANPLAADWLFGDGYTGVPERGR
DEVWTREALMLTGGSTSIRRFEAPLREAGAAARVLLCQAAARRWDADWRDCTTADGFVVQ
GDRRLRFGDLAEAAASGSLPAELPYRIGDEGRLSGQSVPRLDVPAKVDGSANFVADVRLP
DMVFASIRQAPHRDARLRSADVAAAERVPGMLHVVRNDRWIAAVANNWWAANRALNALAP
RFEGPVPPDDAAIDRALGAALEAEGYPVSQTGDVAGVFAGGRLIEAEYRVAPALHAAVEP
PAATAHWQNERLELWAATQAPSLARAAAARAIGVSERQVILHPMLSGGSFGASLEVDVVA
QAAILARELRRPVQLAWSRGEALLHDRVRAPARARMAVRLAPNGAILAWRARIAAPATGR
DLAARLLPDDPLRRLASALPPGADDYALRGAVPPYRLGASAVWHHPVALDLPTGHLRGGA
DGYNAFFTECFLDELARVAGSEPMSYRVGLLGGEPRLARCLTTVAALGGWSGGVPGSGQG
IACHRMADSRIAVLAEAGFDAGGRPRVDRLVAAVDCGRAINPDIVRQQIEGGLIFGAATT
QAAAHYHDGLASIRRYSEIGLPTLADAPEVSVELIDSTADPGGVADLGVPAVAPAIAAAL
FAAGGTRWRHLPFRSA
>A0A7W8PAJ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. HC6.4b|TrEMBL
MGEIVNLSRRGVLKGTLAGGVVLGLQIGGAGTALAASVLSSANGAKGAFAPNVYVSVAPS
GEIILVVHRSEMGTGIRTSLAMILADELDADWNAVKVVQAQGDAKYGDQNTDGSRSIRQF
FQPLREAGGTARQMLVAAAAVQWRVAPATCHTEPGHVVHAASGRRVAYGALATAAARQPV
PSRDTLHLKDEGTWRYIGKSLPIVDLDDIVHGRATYGIDVVLPRMTYASIEHSAVYGATL
KSVDSTETMKVPGVLHVVRIPAAPLPAGFQPLGGIAVVATSTWSAMQGRRKLRLDWDLGP
NASYDSQAYRKALEDTARQPGKIVRNNGDTAAALKSAAHHVSADYYVPHLAHAAMEPLAA
TASYANGAVEVWTATQNPQQARTTVAQVLGVQERAVTINVTLLGGGFGRKSKPDYVAEAA
FLSREVGAPVKLTWTREDDVHNDYFHAVCAQHMEGGLDAQGKTVAWLHRTVFPSISSTFK
ADVRYGAAGELGQGVTDMPYDIANVRCENGAASAHTRIGWYRSVYNIPHGFALGAFVDEL
AAAARQDPVQHLLTLLGTPRHVDLHALGVDYPNYGASIDEYPIDTARHAAVVRAAAVRSG
WSTVLPARHGRGIAVHRSFLSYVAAVAHVQVADDGSVRVTRVDLAVDCGRIVNPDRVIAQ
FEGAVVMALGNTLYSELTFRNGASEQSNFTDYQVARIDSVPETHVYIVPSDAPPGGVGEP
GVPPTSAAICNAIFNATGQRIRALPVDTSLLKRT
>Q1DBH1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Myxococcus xanthus (strain DK1622)|TrEMBL
MADTLKSDATVSEGLDRRRFLTWVMTSPTLMIAARLGPDVPEAEAAERPEGATTAMSLYL
AVQTDGRVVTTLPRTEMGQGITTAVAMLVAEELDMALDQVDVRSADADPRWAIQLTGLSS
TMRFLTGPLRAAAAEARARLVTAAALRWRVLAHTLATSHGVVSAPDGRRAGYGELAEDAA
RVLLPAVSSQPRPVSRFKLVGQPTGRIDARDIVTGATRYALDLDIPEALPTVVARPPTLR
GTVQSVDDASARAMPGVVAVVPLGTGVAVVARTFGQALAARAALRITWTPGPASALSDAD
IRTRLRDGIGPRPLPPLFTTRTLEGRFDFPYLAHATMETQSCLARVQGGQAEVWLGAQDP
KYAQREVARALGWELTPWRVTVHIARAGGGFGRRFFTEAAVEAALVSRAIGRPVKLMWSR
DDDMRHGHFRPASHHRILAYLGPGGRVLGWHHRAAIPTVEFPHGFGDALTALAGEVLPEV
TSAVFFALSQKLPYGFGWVSQELRDVAIPIPTASFRSVFTSQVGVSNEVFVDELARELQV
DPVALRRERLTSNRLKAVLDKVATEGQWGRSLPPGVAQGVAVLEEWDSAIAHLIEVDVTG
GTPRVLRIVIAADVGLPINPKGIEAQLQGAAVDAMSTTLSAGIHIDAGTVREGSFADYRW
MRMKHVPSDIQVHLVRSDDRVGGVGELGYPSAAAALTNAIARARGSMPTRFPILDEGV
>A0A7Z0DKA5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides panzhihuensis|TrEMBL
MTEIQEDIGMEPSIGRHSVGRRRFLGYLIGGTTVVAAAELGLLSGQVAAKIPSAPQVFDA
YDLSDLLTHAAQPTSGLITVTINEDGTASFALPRAEVGQGITTAAAMIIAEELDLPLKKI
DVTLAPARPELVWNQITGGSNTIHAMYTPIRVAAAVAKKALLEAAAAQLDGAVDELETRD
GVITDALGNSLTYGELAAQAASPDTKAVEVGLKDEAKFTLLGKPTNRIDALDAVTGKKVY
TTDLDVKDALPTMLCRAPTLNGKPKKVLNAAEVKAMPGVTHVAMVPTGVAVRARTFGQCI
DGVRALRVDWEDGPVAGESDQDILSGVKAAELPMPSLPNTPIAKTIAYDFTFWFRSNSPM
DTNSAIADVRSDRAEIWSGLKNPIVTQQQIALELGLTPDKVKVNVMQAGGSFGRRLFFDG
AMEAAQVSKAMGVPVKLMWHRSDDARVGRAHPLATSRVRAMHAAGEVLAFQQSHTAVEMD
LRHGFGEIVTALAADLPAGLGNLGYAQTIFTLTSGIPYDFGVLTQTLNETDTRFNTGAMR
NVYSPDVRTANELVVDQLAKAMGKDPLAFRLAFCRNERVRGVLKKAREVAQWGKPMPAGT
AQGVAVHVEYKGASACVVEIDCRPETVGRKVRDAVTGPRVMKATMVTDVGQVINPRGVEA
QMQGAINDGIAMTLTSSLHLVDGHFEEASWDNYFYTRQWNTPPEIEVVIMDSAEPPGGVG
EAGVAPTAAAVACAYARAVGKVPTEFPINHRDPLAFEPKPRTPPIPPSPTDGLRWTY
>A0A7Z0ISL6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides panzhihuensis|TrEMBL
MPTHTFIVNGKRVSVDVADNVRLLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVQVKDIGSDDEITTIEGLPETVGADLHPMQEAWLDEDVAQCGYCQPGQIMAAVDLVRRV
KAEGRDITDDDLDGLRNICRCGTYPRLREAIKTGAARM
>A0A1B9VG80|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassospira sp. KO164|TrEMBL
MTINVSRRGFMIGSAAGTAALLVGVNAKGALASGGSVAAATDLNPFVKIDADGTVTVIIK
HFEMGQGTTTGLTTLVADELDADWDTVQTAFAPADNERYANLFFHAQGTGGSTSIANSFM
QYREAGAAARDLMVRAAAQSWGVDASSITVDNGVLKSGGNSGHFGEFVAIASTLEALEKP
TIKTPDQFKLIGSEKLHRKDNSGKINGTAMFAMDVNLPGMIYAAIMRSPKFGGTVVSFDD
SGAKDVAGFIAAQVLPNKAGVVAFGKNTWSAFQARDALSVEWDFSQAETRSTDAMIADHK
ALLDAPQFDANHEVPLASVEPLLANAAKTIDAEFTFPFLAHAPLEPENCIIEPTENGVRV
HDGCQFPTLTRPMVAAALGLEPSQVEIRTLYAGGSFGRRANGASDYNVEAAMAFAVSGRK
VPVKLVWSREDDIRGGYYRPMAAHRAKIGLDSDGKIVGWDHRLAVKSIMKGGPMEGMVQD
GIDPTSVEGVTESLYTIPNHGIGLSDFQTPTPILWWRSVGHTHTGYVMETLMDMLATETG
QDPIEMRLAMLDPAGANQARMIEAIKLVREISGWEKGDKRGFAAHISFNTCVAVVADVTV
EDTSVHVNKLFMAVECGVAVNPDVIRAQMEGGAGYALCAAFRNEITLTDGEVDQSNFPDY
ELLRNAEMPAIEVAIVQSNNAPTGVGEPGVPPTAPAVANAIFAKTGKRITDLPMTKAGFD
FV
>J2F7K8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens Q2-87|TrEMBL
MSALNINGRDYTVDVDPTTPILWTLRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGKKITTIEAATDGSDPVGSAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTVAEIDSAMAGNICRCGTYARIRAAVADAAKALA
>A0A7W6BN69|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingobium jiangsuense|TrEMBL
MEAIGGAIGAAIDRRMLLIGGGAAAGLLIAWGVWPRSYRPNLAKGANETLINAFLKIDTA
GQIIVVVPQLEMGQGVTTVLPQILADELGADWRTVAVQGAPISPLYANVLLARQFLANDW
SRLAGGAGDWVLEQIATREAMMLTGGSTSVRAFAQSYRDAGAAARVLLCKAAAARWDVSW
ESCSIVDGLVTDGQRKLRIGELASEAAGFSLPDILPERSPDDDNKRLLGQDVPRLDLPSK
VDGSHNFAADIRLPDMLFASIRQGPPGAVRLVSTKEAEAAKITGFLQLVKRDQWVAAVAT
NWWAANKALDLLDPTFETDTPPADSKAIAQALEDAFDGDRGRRIHERGDLAKSFSGARLL
HADYRVAPALHLAMEPPCATARVSDGRAEIWVASQAPAFCRRAVADALGMAEEAVVLYPL
SAGGSFDRRMDHEAAVQAALIAREMKRPVQLLWSRAEDIITDRPRPPAHARMTARLVTGG
MIDGLAVKIAAPAADAETWARIAHRTPATEAAARASAQADARAVSGLPAPYAIPNIAVDH
YPAAIGLPTGRWRGQADSYTCFFTEAFMDELAQKAEIEPMSFRVQHLGHDPKLAQCLTTA
AAMGGWQGGVAGSGQGLACHRMDGGAIALLVEAGMENGALRAKSIIAVADVGAQPHPDIA
RQQIEGGIVFGLAAAMGCAAQYDQGLPARAILGRLGLPRLAHVGAIHVELLPGDGEPAGV
GQIGVPPLAPALAGALFTLTGRRHRSLPLIPPA
>A0A2R5FD57|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novimethylophilus kurashikiensis|TrEMBL
MSEINVSRRGFLKAAGVSAAGLVIGFYLPGVRGRAIAAEAPAQQIQYPPNAFIRIAPNNT
VTLLINKSEMGQGVYTSLAMLINEELEADWSKVKVESAPVAPVYNHTVFPIQLTGGSTSV
ASSWEQMRRIGATARIMLVQAAARQWQVPVDECHAENGVVTHKSGKKLSYGELADAANQL
VPPTVVPLKDPKDFKLIGKSTKRLDSPEKVNGKAQFGLDVYLPNMLTVVVARGPVFGGKV
KRFNADEARKVPGVKAVFQVPTGVAVAATGFWPAKTARDLLEVEWDEGPGGQLSTAGLMT
EYTDLAKQPGKVANKHGDAVSALKEAGKTVSASYAVPYLAHAPMEPLNCVVDLRKDSCEI
WTGTQFQTVDREAAAKIVGLKSEQVQIHTTFLGGGFGRRANPVSDFVGEAMHVAKHLKQP
VKVMWTREDDIHGGFYRPMWVDSIEAGIGADGKPVAWRHTIVGQSITTGTPFEGFMVKDG
IDATSVEGAADLPYTIPNLQVDLHSPRHEVPVLWWRSVGHSHTAFVVETMMDEMAHLAGQ
DPVAYRLDLLEGSPRHQGVLRLAAEKAGWGKPLPAGRAYGVAVHKSFESYVAEVAEVSID
DGKVRVHRVVCAVDCGRVVNPDGVRQQLESAVVYGLSAALHGEITLDKGRVQQSNFHNYP
PLRYTEMPTVEVHIVPSEAAPTGIGEPGTPPVAPAVANAVFALTGKRLRSMPFDKTTLA
>A0A7W6T849|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. SBR1B|TrEMBL
MNFIDNPGKLHSFEKRGFEKNIKVEKVSRRSILKGLGITGGFVLAAPVMSRQALAYETGA
GKMPHGVVVDPRVFVSVGPDGIVTIVGHRSEMGTGVRTSLPLIVAEEMEADWSRVKVQQA
HGDEVKFGNQDTDGSRSTRHYLIPMRQIGASARTMLEQAAAKRWGVPATEVKAVNHEVVH
SASGRKLGFGELAADAAKESVPSIEGLKLKDPKNFRYLGKGQVGIVDLHDITTGKAHYGA
DVRLPGMKYAVIARPPVTGGKLVSFDPDAALKVPGVEKVLKVQGWPWPSKFQPLGGVAVI
ARNTGAAIKGRDALKLVWDDGPNGKYDSVAYRKELEEASRKPGLVLRKEGDADAALKGAD
KVIVGEYYVPHLAHVSMETPVAVADVKGDKAEIWAPVQSPGGTREDVAKTLGIPEGNVTV
NVTLLGGGFGRKSKCDFALEAALLSKELGAPVKVQWTREDDIHNGFLHTVSVERIEAGLD
KSGKVVAWRHRSVAPSIASTFAAGTVHQAPFEIGMGLVDMPFEIANISCENPEAAAFTRI
GWFRSVSNIPRAFAVQSMVGEIAQATGRDQKETLLALIGSPRIVKPEVKDLWNYGEPQES
YPIDTARLRKAVELVAEKGEWGRKVPKGHGLGIAVHRSFVSYIATIVEVAVDDKGKLTVP
RVDTAIDCGTYVNPERIASQIEGAAIMGLSLAKYGEITFKDGKVQQKNFDDFQVVRMDES
PVVTNVYIVPPGPDTPPSGVGEPGVPPFAPALINAIFAATGKRIRSLPIGKQLEA
>A0A7W6T839|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. SBR1B|TrEMBL
MIKVKINGQEQSWDGDPDLPLLWFLRDEAGLTGTKYGCGQALCGACTVIVDKQAVRACIT
SVNDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLMDNPKPSHD
QIRESMSGNICRCGCYQRIENAVHLASTGV
>A0A095VTQ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudohaliea rubra DSM 19751|TrEMBL
MIKFTVNGEAHSVEGDGTLPLLWYLRDIAGMTGTKYGCGAGLCGACTVHLDGEAVRSCVT
SVAAAEGKAVTTIEGLAENADHPVQQAWAKHQVPQCGYCQPGQIMQAAALLAKTPSPDTD
AIDGAMAGNLCRCGTYPRIKAAILDLAEPAS
>A0A0A1FDR6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas arenae|TrEMBL
MPTVFNLNGKKVSVEAEPDTPLLWVIRDEIGLTGTKFGCGVALCGACTVHLDGQPVRSCQ
TPVSAVASKKVSTIESLSKDNSHPLQKAWIAHDVPQCGYCQSGQLMSAAALLATNKNPSD
SDIENAMSGNICRCGTYNRIRAAIKSAAAEMRNKA
>A0A7W5HVQ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. Tn43|TrEMBL
MITLKLNGKDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVAGQNVTTIDNLHADPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A564G4R0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium dankookense|TrEMBL
MITLTINAQPYRVEAEPDTPLLFVLRDSLGLTGTKYGCGIGQCGACTVLLDGQAARSCQI
PLESVGDQAVTTIEAIEQDPVGARVVAAWVGIEVPQCGYCQSGQVLAATSLLKQTPKPSE
DDIAGAMTNLCRCGTYNAIAAAVRQAAA
>A0A1J5T1L3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|mine drainage metagenome|TrEMBL
MISFNLNGKSTKVDVDPSTPLLWVLRDHLHLTGTKYGCGISQCGACTVHLDGKAIRSCVT
PVSTANGKHITTIEGLAETTLGKAVQAAWLEVDVPQCGYCQSGQIMSATALLKENPHPSE
SQITAAMEGNLCRCGTYNRIRSAIRTASEQLGAAK
>A0A0J7LZG1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter subterrani|TrEMBL
MRRSDDTLLLANVSRRGLLKGLAGASALVLAARWDLADASEKDRFGASAMPGGWVDNPNV
FIHIAPDGTVTIVNNRSEMGQGIRTSLIMVGADELGADWDRVKVEQADANQEKYGNQNTD
GSRSMRHWYDPMRRAGAAARMMLEQAAANLWGVPVHEVETRVHKVVHEASGRELGFGELA
KAARELDVPGRNDLVLKADSELRFIGKESGLINGELKSAYPKAIDGEDIVTGKAIYGADV
DFEDTLYAVIARPPVYGAKVKSVDDSAALKVIGVQKVMQIEGASQPAGFSPLGGVAVVAS
NTWAAMEGRKALKIEWDNGPAGDNAGYTTEAYRQSLEKAAQSPGKVIRENGGDVEAALQA
AAKRVSATYYMPHMAQAPMEPPVATVRVKDGKAEVWAPVQNPRATREGVAGRLGLDKEKV
TVHVTLLGGGFGRKSKPDFVTEAAIIADAVKGRPVRLQWSREDDIHHAYFHAVSVDHLDA
GLDADGKATSWRHRTLSPSIASLFAPDPEHIQEFEQGMGFNTMPFDIPAIRLENPPAPAY
VRIGWFRSVYNLPHAWAIQSFAHEMAEAAGKDHRDYVLDLLGPGRQIQNLSVGDGWNYGE
NPDLYPIDVARMRRVIERATEEAGWGQKPGKGRGLGLAFHHSFVSYTAIVFDVEVDDKGD
LTIHRADIAFDCGPQANPERIRSQLEGACVMGIGIGLKSEVTFKDGVAQQDNFNNYLIPR
MPDAPGVVRVHLIDNPTDAMGGVGEPGLPPVAPALCNAIYAATGKRIRRLPVGDQLKG
>U2WVY9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MSKSFGSSLVYFTLPTIGFGYMYGLINLYLMIFATDFLAIAPATVGFIFGISRLWDAISD
PLIGHLSDNTRTRFGRRRPWLVIAAVPLGFAFYMLFNPASGSEELITILWFGAAVILFYT
ASTLFYVPHFAIAAELTEDYHQRNIVFGCRHAGWLAGYVMSLGGIYSLTMLHSEGAEKVI
DFAGKQATFIGSLTAISVLICAYGMREKPGFAERRSTSVLPVIKDVFKNMYARRILIVNF
MDNVSFALTSTLVIYVCTYILNDANIASVFILFFMLPSLLLVPIWMPLARKFGKKNLYTF
SMLLSGTAFGSLFFADYNNLAHLYIAGIMAGTANGCNNVIGPSIFSDIIDYDELQTGDRK
EGAYFAVWSLVWKSSTAIVLFILGMVLSFVGFEPNVPQTDLVIDTMKFMFTLLPCMFYIL
AAFMFSFFKLNEETYNNIRTELDTNREATQL
>A0A7U7EI21|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas stutzeri|TrEMBL
MSQPDTTLQSPSRRTLLKVGSLALGGLVIGFTLPFAGRSFAEQILNEGPEDQPMSNATAL
DAFISIDRDGQVTFTVPKIEMGQGAQSGLAVMVAEELEIGLEQITLKEAPPNEQIYNDKL
LNFQATGGSTSIRSNWEPLRQAGAAARLLLIQAAAQRWQLGADQLRAENGRVLGPDGQSL
GYGELVEDAAKLPVPEDIPLKPADQFRLIGKPTRRLDTPAKVDGTARFTIDLVVPGMKYA
SIRACPVLGGTLREVDERAARQIPGVIEVVRLDNAVAVIGEHTWAAFAGVRALEIDWALG
DNAGIDSAQMEREIRGALDKPGAIANEQGDIDAALKDAANTFEAEYEMPFLAHAALEPMT
CVAEVRADAVELWVGTQVPVRAQTAAAEAAGRPVEQVIVNNQLIGGAFGRRLEVDFISQA
VAIAAQVDYPIKLTWTREEDTTHDMYRPHYIDRFAAALDAEGRLQGWRHTIAGASVLARF
APEAVPENGLDGDAVEVAMHPIYAMPNLRVNYVPVPPRALHQSWWRGVGPLRSTYMLESF
IDEVARSVEQDPVDYRMALLGSHPRAQGVLRLAAEKAGWGEPLEAGHGRGVAVQEVFGSF
LATVVELQVSEDKGIRLKRLVVAIDCGQVMNPVSVKSQIEGGTLFGLSAALFNEITVREG
RVEQTNFHDYRQLRISDAPPVETYIVESREAPGGVGEAGTAMIAPALVNALAAANGTRIR
RLPLARAGYYVI
>A0A1E7WLY3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella phyllosphaerae|TrEMBL
MRIEWINKDNVDAALVSQAATATPAGVSRRGFMKTGAAAGGGLVLGFFMPGAGRFANAQQ
PPAKVYEPNAFLHIAPDNTVTVQVNRLEFGQGVQTSMPMLIAEELDADWSKVHGALAPAG
DQYKDPAFGIQITGGSGSIAHSYTQYREIGAKARAMLVAAAAEQWKVTPAQVKAAHGVLT
GPAGQSATFGAMADAAMKQPVPATVTLKDPKDFKIIGKPVKRLDAKLKSTGKQQFGMDFK
APDSKVALVARPPVFGARVGKLDASKARAIKGVLEVLEVKTDRGGSGVVVVADGYWPAKM
GRDALVIDWDTSAVEKVSSAQQLKDFKALAQKPGASARKADTSKLAGAPKKINAVYEFPY
LAHAPMEPLNCVVDLRADGCTVWAGTQFQTVDQGAIAATAGLKPEQVVLNTMMAGGGFGR
RGVPSSDYLVEAVNVAKVWRAAGKTDPVKVVWSREDDIKGGYYRPSHVHRADIGLDAQGN
IVAWDHVIVGQSIAAGTMFEPMMIKEGVDSTMVEGMGEPYDVPLNLSAHIAKANVPVLWW
RSVGSTHTAYVMETLIDEAAHSARMDPVAYRKKIMGEKGKRHVAALDLAVAKSGYGKKAL
PKGQAWGVAVHESFNTVVAYVVVASVKDGVPKLHKVTAGVHCNTAVNPLTIEAQVQGAAL
MGLGMTIPGAAITLKDGVVEQQNFSDYSVARMTDMPAIDVHIVPSNDPPTGMGEPGLPPL
APAFANAVFKITGKRLRKLPFDLASA
>A0A1E7X805|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella phyllosphaerae|TrEMBL
MAQTLRVNGHEHVVDVEGSTPLLWVIRDVIGMTGTKFGCGIAQCGACTVHLDGNPVRSCV
LPVSSVGNREVTTIEAVGATDSGRRIQEAWLAVDVVQCGYCQSGQIMSAAALLKRTPNPT
DADIDSAMSGNICRCATYVRIRAAIKQAATGKIAVTQAIPVTAIGGRK
>A0A081FV92|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacterium sp. AK27|TrEMBL
MEYQLKINGRMRSLNAEPGTPLLWVIRDELALTGTKFGCGVASCGACTIHLNGNPTRSCI
TPVESAVGGEITTIEGLDDPISAAVQSAWREKDVVQCGYCQSGQIMSAVGLLRQNPRPSD
EQIDSFMSGNVCRCATYVRIKDAIKLASDTLEA
>A0A2U3PXU3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium vignae|TrEMBL
MIKVKINGQEQSWDGDPDLPLLWFLRDEAGLTGTKYGCGQALCGACTVIVDKEAVRACVT
SVNDVAGREVTTIEGLHANGDHPVQKAWRQVNVPQCGFCQTGQIMQAAALLMDNPKPSHD
QIREAMSGNICRCGCYQRIENAVHLASTGV
>A0A7Y9L529|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MATQFKLNGKAVQAQAEPDTPLLWVIRDEIGLTGTKFGCGMALCGACTVHLDGEPIRSCQ
TPVSAVAGKQVATIESLSKDNSHPLQKAWIAHDVPQCGYCQSGQLMSAAALLRTNKNPSD
ADIDNAMSGNICRCGTYNRIRAAIKTAAADMRKA
>A0A7Y9L326|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MPLTLKINGHPHTVDIEGDTPLLWVIRDVIGMTGTKFGCGIAQCGACTVHLDGEPVRACV
LPVSAVGAREVTTIEAVGATDTGKRIQDAWLAVDVVQCGYCQSGQIMSAAALLKRNPAPS
DADIDAAMSGNLCRCATYVRIRAAIKQAASGKIAVPQAIPVHAIGGRK
>S6CZW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus 386B|TrEMBL
MPTLMINGQPHSVDVDADTPLLWVLRDILGLNAAKFGCGIAQCGACTVYVDGKAVRACNL
PVGLVGERAITTPEGLDMADPIVRAIKSAWVELDVVQCGYCQPGQVMAAVALLRTTPKPT
DEQIDSAMSGNMCRCGTYMRIRAAIHHAAGELA
>Q5LPM2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)|TrEMBL
MATSLTVNGETHRVDLPDDVPLLWVLRDEIGLTGTKFGCGVAACGACTVHIDGEAVRSCQ
VALGDVWGQVTTIEGTGTPEALSVLQQAWVDHQVAQCGYCQSGQIMQAAALLAENPAPSD
TEIDEAMQGNLCRCGTYPRIRAAIHGAAAKLKEV
>A0A2H6B362|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|bacterium HR40|TrEMBL
MLSAILARNGHSRSLPLLANVSRRDLLRGTVSAGAFVLAARFLPPEAAQAATFYRVGGED
MPNGLVYDPHVFVAIEPDGTVVIVAHRSEMGQGARTSLPMVVADELEADWSRVRIVQAPG
DEPRYGNQDTDGSRSMRHHIQSMRHIGASVRHMLEQAAAQRWQVPKSEVRAELHKVVHRP
TGRSLDYGELAQDLKAMPAPSREEVQWKDPKDFRYIGTGKIAIYDLRDITVGKAIYAHDV
RVPGMKFAVVARPPVVGARIRSYDASRALAVPGVERVVEIPGSDIGAKFAPLGGLAVVAS
NTWAALKGREALAIDWDRGPHAVYDSAEYEKRMRELARKPGKVVRDQGNIEEAFARAAKV
FAAEYYVPHHAHVTMETPAAVADVRDGRAEIWASVQSPWGTRQDVAKLLGVSADDVTVHV
TLLGGGFGRKSKCDYVLEAALVSREIGAPVQVLWTREDDIRHGFYHTVSLERLEAAIDSD
GRVIGWRHRSVAPTILSTFDASAQHQFDIELGMGLVDNPFDIPNMRMENPPIEAHVRIGW
FRSVSNIPRAFAIQSFVAELAHELGKDPKDFLLELIGPPRHIDPVAAGIQDKLWNYGESL
DVYPIDTGRLAHVVRVAAEAIGWGRKLPPGHGLGIAVHRSFVTYVATAVEVAVDEKGRIS
IPVVHTAIDCGFCANPERVKSQIEGAAVQGLTLALYGNLTFANGEAQQSNYHDYPVARLS
DAPKVVHTHIVPHPFEVPASGVGEPGVPPFAPALANAVFAATGKRIRDLPLAKHDLRRI
>A0A7W8W3Z0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MTTLNINGQTHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVF
PAAAVGDRKIVTIEALGATPTGQKVQQAWRELDVVQCGYCQSGQVMSAASLLARNPNPSD
ADIDAAMAGNICRCGTYHRVRAAIKHAAKGA
>A0A0U1NNB2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nereida ignava|TrEMBL
MKLNVNGTDHQIDVEDDMPLLWVLRDVLDIKGVKYGCGIAACGACTVHLNGDAVRSCQIA
AADAVGFEITTIEGMGTPDTMHAVQSAWVDLQVAQCWYCQSGQMMQAAALLQSIPRPTDA
DIDDAMNGNLCRCGTYPRIRAAVKQAADTLAKG
>A0A857JTC2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola mesophila|TrEMBL
MSTLGKITRRTFVIGSAAITGGVLFGVYKYKQPYPNPLEKDLAQGDTALTPYVLINANGV
TIISPRAEMGQGVKTTLAALVAEELDVDVQNVKIEHGVPSNAYYNAAVLEEGVPFPPQDT
SSTAQMARDFMHVPAKFFGVQVTGGSSSTVDAFEKMRMAGATAREALLLAASAKLNVAKN
ALSTDNGEVISKDGQRIAYTELASLAASVELPNDVKLKPKSEWKQIGRPIPRVDMVEKCT
GTATFGIDVLQKDMLYATIKVNPHLGAKCHAFDANNAAKMKGVKAILPLADVGAAVVATN
TWYAFKAAEKIDFDWAKTEYAQTTDELFESAIAAFNEEHQDSQNRNDGDVDAITGAAGDT
TIHREYRAPLLAHATMEPMNATAIIKDGQLDVWVGTQMPTYALSEAARVSGIEAQNIRIH
TTYLGGGFGRRLEMDFIIYAVMVAKQLEGKPVKVTWSREEDMTHDSYRPFAVARFKGVTQ
GKNISALDVQVSSPSVMESQMGRLGVSLPGPDSTIVQALWDQAYTIENYRVTGYRVPMGI
PVSSWRSVGASQNGFFNESMIDELAIEANADPIEMRLSLITHQPTRNVLETVAKMANWGR
DVPENHGLGVALVTSFGVPVAEIVEVVNTPRGIKIVNVYVAADVGIAIDSRNIEAQLISA
VNFGLAGAMMGEITLLDGKVQQTNFHNYDAIRMHQAPVIHTKILENGERIRGIGEPGTPP
AAPALANAIYAATGLRMREMPFNKHIQFV
>A0A1Q8M138|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae717_Ps2|TrEMBL
MPSHTFTVNGEKVTVDVEDDVRVLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
SVPVGAISESDEITTIEGIADGEKLHPMQQAWIDHDVAQCGYCQPGQIMAAIDLVKRCSA
EGRSIDDEALDDIRNICRCGTYNRIRKAIKAGADNM
>A0A7Z0AVB9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MIAFTVNGERRELDEASPSMPLLWVLRDQLKLTGTKFGCGMGLCGACTVHLNGVAVRSCQ
LPLAAVAGHSITTIEGLSPSESHPLQLAWVAEDVPQCGYCQSGQIMSAAALLNTGAPVND
DSIRNAMSGNICRCGTYGRINKAIKRAANAPKEA
>D3P7P3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum sp. (strain B510)|TrEMBL
MNQSSLLHCALDRVFCRARAGSAAANHKIQSIAQSVAKAPTGQRTRRRRVPDHRGRPAVP
FREKEAKAMVRINVNGEERQLDVSDDMPLLWVLRDELNMTGTKFGCGIAQCGACTVHVDG
APTRACQTPVGMLTPDSKVTTIEGVKGKAAQAVQAAWQKLDVVQCGYCQSGQIMSAIALL
TDNQNPTDQDIDAAMDGNVCRCATYVRIRAAIKDAAQTMRA
>A0A5E8AAC6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius sp. EC-HK134|TrEMBL
MRFTLNGLGQDIPADWADEPLLVLLREHIGLTGAKFGCGVGICGACTIIVDGAATRACMI
RSGEIEGLNVRTIEGLSDGDSLHPVQQAWLDLGVPQCGYCQAGQIMAAVALLEETPDPSA
DDIDAAMDGNLCRCGTYPRIRAAIARAAERV
>A0A833JBM8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum populi|TrEMBL
MLKLDLTDAPVPSRRAFLTGAAAGAVLLAFRLDLKGARAAEASDALSKGPAQPNAFVRIA
ADDTVTVMIKHLDMGQGNTTGLTTILADELDADWAQMRVAFAPADAKLYANLLMGPVQGT
GGSTAIANSWFQLRKAGAAARAMLVAAAAETWGVPAGEITVAKGVISHKSGKQARFGEFA
EAAAAKPVPQEPRLKTPAEWTLIGGRVPRIDSVAKTDGSAIYSLDIRRPGQVTALVAHPP
RFGATVKSVDAEAAQGLPGVVGIVTIPTGVAVIARDTWSAMKAREALKITWDESAAETRS
SDAILAEYRETAKTSGLVASQAGDADAGIKGAAKVLEAEFSFPYLAHAAMEPLNATIERA
ADGSYDVYAGCQIQTIEQAVVAATLGVTTDKVRLHTQWAGGSFGRRATPGADYFAEAAAI
VKAWDGKAPVHLVWTREDDMTAGFYRPQVYHTVKAGLNEKGQITGWRHAMVGKSIMIGSP
FEAMLVKNGIDSTTVEGASDTPYALPAYRFEVHNAREGVPVLWWRSVGHTHTAHVMEVFI
DELAHAAGADPVAYRLSLLTRAPRLSGVLRLAAERAGWGGKSSEKGRGLGVAVHESFGSY
VAMVADVTAADSNVRVNRIVAAVDVGVAVNPDVVRAQVEGAVGFALSAVLRNRITLKDGV
VQERNFDSYQPTRISEMPRVEVHIVPSEVAPTGIGEPGVPVLAPAIANAVFAATGQRVRS
LPLDLSGLRGA
>A0A0M6YDS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia donghaensis|TrEMBL
MASVGKIARRSFLIGSAAVAGGVAFGVYAWRKPVDNPLLADLPEGATTLNPYVMIDADGV
TLITPRSDVGQGAVSIQTYLLAEELDVDPQTVRTSFGPASGAYYNGKVAAEGMPFAAWND
GLVSRVGRSAAGPAAKFLGLHITGGSTTVPDMYDRLRAAGATARETLKQAAANRYAFVRA
DLRTEGGAVILPTGDAVPYADLAQEAAALDPIEVAPRAAEGWKWLGKNMRRTDMVAKSTG
TFRYGGDLVLDDMIHATVVTNPAMDGGVVSVDDAAARAMRGVEDVVPITDGFAVLADNTW
RAMAAARALAIEWDVPTGRPADSDAMWEAHTAAFIDDAQDSRFADDGDVDAAPGDLVTAE
YRAPFLHHAPLEPANATVLYTEGGTQVWTATQVPIFVRDAVAAITGQDADLVQVHNQPSG
GSFGHRLDYLWVQQAAEIAVQVPGRPVRLTLSREQDMTHGFLRPMAIARGRGTVDDGQVR
SLDLSIAAHSVTESQIGRAGLPAVGPDVAIVAAAWDAPYAIPDRRITGYRVPAGVGVSSW
RSVGASHNGFFIESLLDELIAEAGADPVAERLRLLHDDASRGVLEAVADMASWNGPLGDG
KGRGVAFTIAFGVPCAQIIEVSDTEAGIRLDKLWIAADVGQVLDPVNLESQLSGGALFGL
GHAMHAEVTFDNHRIQQTNYHEYESMRLWQTPQVEVRTLETLPTIRGAGEPGLPPAAPAL
ANAIFAATGTRLRDMPFAKSVRFA
>A0A7Y9RZV2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides daedukensis|TrEMBL
MPRQSFILNGETVTVDVADDVRLLWVLRDLLGVTGPKYGCGINVCKACTSHINGKAFNPC
AVPVGALKKGDEVTTIEGLPDTAPQAQRGPNGLHPMQEAWLERDVAQCGYCQPGQIMAAV
AVVRRAQAENRTVTDEDLDGIRNICRCGTYTRIREALREGEQAMRG
>A0A679JSA9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium bullatum|TrEMBL
MLKLNVDGVSHDVDADPDMPLLWALRDHLDKTGTKYGCGIAQCGACTVHLDGQPVRSCQT
RIGDVGEAKITTIQGVSGRVAEAVQTAWRGLDVVQCGYCQSGQIMSAIGLLSTTPKPSDA
EIDGAMDGNICRCGTYQRVRAAIHEAARSLA
>A0A166A794|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio axinellae|TrEMBL
MYPKQNLTVNGQTKEIEADPEMPLLWALRDILDIKGPKFGCGIAACGACTVMIDGEAVRS
CVQPVGDVTGAITTIEGISQGDELHAVQQAWVKHSVPQCGYCQSGQIMAAVALLEEIPDP
TDEDISDAMTNLCRCGTYPKIRAAIKDAAQALGA
>D8NGC4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum CMR15|TrEMBL
MVTLTINGKPVELDADPSTPLLWALRDNLGLTGTKFGCGVASCGACTVHLNGQPTRSCVL
PISAVVGAQITTSEHIADDKVGRAVLAAWIKHDVAQCGYCQSGQMMSAVGLLRSKKTPTD
ADIDSAMAGNLCRCATYQRIRAAIHDAAKALA
>A0A0P1H5J2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Leisingera aquaemixtae|TrEMBL
MASFKKIARRSFLIGSAAIVGGVAFGAYYVSRPAPNPLKPGDGEVAFNPFVMISDRKITL
IAPRAEMGQGVHTTWAALIAEELDVTLEQVEVLHGPAAKAYYNSALMSEALPSTGYDKSR
FMHSLGELLGQAGKLLDLQVTGGSTSMKDGFERMRLAGASARETLKEAAAQRLGVSRGQL
STKDGTVVAPDGAEIAYTELAADAARLEPVDAPLRPRSEWRLLGKSQPRVDMADKATGTA
QFGIDVRLPGMKFAALKANPHLGGAMKGFDAAAALQMPGIERVADLGDAVAAVGRNTWLA
IQALEAIEFDWGAAPIPASQEDISAAIRAAFEAKPNSTLRDDGDAETLPDGAQEVTADYE
VPYLAHATMEPLNATALFDGSRLQIWCGSQGPMLVRDHCAKALGIAPEQVEVNTTLMGGG
FGRRGETDFAVYAARLAGQMPGTPVQLTWSREEDMTHDFYRPASVARFRGAVKDGKALLL
DGQIAGQSPTAQAMKRWIGLPPSGPDAALTDGAFNQPYAIPNYRIRGYAADLQIPVGFWR
SVGASINGFFMECFVDELAHAAGADPLAFRLELARQEWAPAAKVLEAVREMSGWTGTTPE
GVGRGVAMTYSFGTPVAQVIEVAEEDGLIRLRKAWIAADLGVGLDPRNLEAQMFGGMAYG
LSAAMFGEITFADGAAEQVNFPDYDAIRMHTMPQVEVRILEEQPHIGGAGEPGTPPAAPA
LANALFDLTGKRARRLPLARDFDLLA
>A0A7X6BB29|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas trueperi|TrEMBL
MPYLLTVNGQRHRIEADGETPLLWILRDTLYLTGTKYGCGAAQCGACTVHLDGAPVRSCS
VPLNALGTAEVTTIEGVDGPQAQAVRDAWVARDVPQCGFCQSGQVMSAIALLRAIPMPSD
ADIDAAMGGNLCRCATYMRIRAAIHDAAAAVAGASA
>A0A1L3LG27|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium americanum CCGM7|TrEMBL
MAIVTINGVEHSVDAAADMPLLWVIRDLVGLTGTKFGCGMAQCGACTVYVDGSPVRSCQT
FIGDIEGAQVTTIEGLKGKVAEAVQAVWADLDVPQCGYCQSGQIMSATDLLANNPKPTDE
DIDAAMSGNLCRCATYHRIRAGIHEAAKRLEG
>A0A7X5Y151|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas trueperi|TrEMBL
MAGNTPPRIRLDRRRLLIGGGAGLGLVVAWGLWPRSYAPNLSAGPGESLFGAWLKIGKDG
QVRVAVPQAEMGQGVYTALPQILADELGADWKLVGVEPAPLNPLYANPLAAQTLFSAALG
GLPEKVQRSHAARADLMLTAASTSVRAFEEDLRQAGAAARVLLCKAAARSWGVDWQSCGT
AGSTVIHGNQRLGFGDLAEAAAQEKAPAQLPLRGGEAGRLLGQPLPRLDAPAKLDGSANF
AADVRLPNMVFAAIRQGPVGETELVHVDREAANRVRGMLSIVTTKQWVATVASNWWAAER
ALQALRPRFRNPAAVVNDDSIDAALDAALEGEGARIEAKGDLAAEFRGAKVVTADYRVGL
APHAPLEPMTCTADYAHGRLSLWLPTQAPGLARAAAAKALGVDPARVTVHAMLGGGSFGE
KLEVDAAVQAALISHAVQRPVQLTWPRDEDLRRDRFRPAAAARLTAKLGQGGTVSAWLAK
IAAPTTGRELAARLLAGDTVAAAGLALPGRQDPSAVEGAVPAYAIPNLAVDHHPAEIGVP
TGYWRSGAHSYTCFFAESFVDELAHVANRDPLSFRMAMLGNQPRLARCLQTAAQLGGWQG
GEPGSGQGIAAHAFRGSYIAVMAEAHLTPQREIVVERLVAAVDCGRVVNPDLVRQQIEGG
LLFGLAAALGASTTFSENIADVQTLADLNLPTLASTPDITVEILPSGSDPGGVSELAVPP
TAPAIANALQTATGTRFRRLPLLSDAE
>A0A375BD72|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLALLQATGVLLVTRAPQAAARPAPGQPGAASDYVPALPD
LFIAVRDNGEVLAFNGHVDLGTGIRTALAQIVAEELDAPLDSVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAALQLGVDVSALEAENGEFRVRGTQASIRYAALV
AGEHVELPLAEDVPVKPVESYRIVGRAAPRVDIPGKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLAIDRDSVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVQW
KPVPPLPALDDPEPALRANPATRRELLTEGELPAGGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEDGLTVWSGTQNPHMLRIDLSRLCGLGEDRIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVGRPVRVQLSREQEHLWEPKGAAQLMDVCATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALAAGVDPVDFRLRHLPDERAADLLRAVADAAGWQRGAAGARGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDAGTGRIAIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVVLMPRQSEPPLGAGESA
SLPGAPALANALFDALGVRLRRPPFVPETVLAAMASRTSRTSAAPTKG
>A0A7W7F6U0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingosinicella soli|TrEMBL
MQLIINGKKHTYDGDPEMPLLWYVRDLQGLTGTKFGCGAGLCGACTVHVDGAAMRACQLP
MAALADQSVTTIEGLSAEGDHPVQRAWRQLDVAQCGYCQSGQIMQAAALLAETPNPTDAD
IDAAMAGNICRCGTYARIRAAIKAATSAVNA
>A0A375J2D4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLEVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVRAAVGHAVTTLEGLGTAQHPDPVQQAFIEEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQAAQGAAS
>A0A375D6H1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MADLARLSRRGFLRGSVGLMTLAVTSGGLVTVARAADPAPKKFGADSMPGGTVDNPLAFV
SIAADGTVTIVAHRAEMGTGVRTSLPMVVADEMEARWERVKVVQAEADETRYGNQNVDGS
RSVRHFLMPMRRVGAAARQMLEAAAAARWSVPVSEVRAVQHEVLHQPSGRRLGFGELAAD
AARQPVPKGDALRLKPRAGFRYIGKNAVRPVDQEAIGSGRAVYGMDLRLPGMVYAVVARP
PVVGGKLRRLDSRKALALPGVLKVVEIPAFQGAPAFQPLGGVAVVARNTWAAMQGRAALE
IEWDDGPNGSYDSTAYRRTLEAASRTPGKAVRNQGDAQRAWDTAPPAERLAADYYVPHLA
HASMEPPVATVRIRGGSAEVWTSIQNPVAAQTAVARRLELKPGNVRVNVLLLGGGFGRKS
KPDFVDEAAIVAQAMPEGTPVKLVWTRDDDIHHDYLHTVSAERLEAVIDRQGQVKSWLHR
SAAPTIASLFTEGAKGQQMFESAMSAINMPYRIDNVRVETAEVPAHARIGWFRSVANIPH
AFAAQCFIAELAHRAGKDHRQFALDLIGPARKIDPGTLADTWNYTESPERYPYDTGRLRG
VIEAATRGAGWGRKLPRGHGLGLAFCYSFMSYTATVVEVAVDAKGEVRVVAVDMAMDCGP
QIHPDRIRAQMEGGAIMGLSLALASEITFDKGRVMQSNFHDYEVLRHHASPRVIRTHLVN
DNHDLPPGGVGEPPVPPVAPALCNAIFAATGKRVRSLPVRKVA
>A0A375DWP9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MNTPRPLTLQVNHAEHTLEVAPDTPLLYILRNDLCCNGPKYGCGLGQCGACTVLVDGLPA
RSCVLPVRAAVGHAVTTLEGLGSVQHPDPVQQAFIEEQAAQCGYCLNGMIMTAKALLAQN
PDPDEAQIREALRFNLCRCGTHVEIVRAVRRAAVLQRQAAQGAAS
>A0A375BWP5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEARADAGVAPLDRRSFLKLTGLAGGGLALGVAPLAQAQEGNK
PKAPPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVVT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKSFSADKARAVPGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALAVQWDDAGSKVSSQALFDEYAKLAGQPGTVARAGEGDIAAAIQRAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGRVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVEK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVSAGVHANRVVNPLSAE
AQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDFPPPRITDAPVVEVFFVPSQDNPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>S2D5K9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)|TrEMBL
MEPLKTNRRGFIKATGQLLIGFNLFPLTFCGTKEGDGYAISPYQGIPERPHVDRSLIDSW
IRLDAEGHVTILTGKQELGQGIRTALMQIAAEELDVNMDICHIINGDTGQTANEGYTAGS
NSVEGSGKAIREAAAEAREFLVKKAASDWGTKVNEINVQNGIIYGPNDQKTSYWELVDGN
FYEAKVSGKAKEKEPKDHQIVGKAIPREDIKNLVKGVAHFVHDLRLPGMVHARVLHPPSY
SSQIIKTDLSSVNEMPGVLKVIQNGNFLAVIATREYQAVKAWQKLREVTDWEAKNINILP
EQLFDDMIKSSEKAELIEDSPGITQQIRQSLQKLKSTYMRPYHMHGSTGPSCALAKWENN
QLTVWSPTQGVYPLQVTLADLFDLETENIRCIGMPGSGCYGHNGADDVSAEAALVAKAYP
KAPVRLQWMREDEHMWEPYGSAMRIELEAGIDQEGLVTAWDTQIWSDTHSTRPRGDAGHY
ISARHLEEPFEFKKGNFSGGAYRNATPLYNISSKRLRLYNYDGPLRTSALRGLGAYGNIF
ALESFMDEMANLAAVDPLEFRKNNLDDPRAIAVLDRLAKESNYHNRIQQSNTGYGLAFAK
YKNSAAYFAVLAEVEINQENKSFHLQKLTGVIDAGQCINPDGLINQTEGGMIQSASWTLL
EEVKYDEKGVLSKDWITYPILRSKETPEVIVHIINRPEEKPLGAGEAAQGPVAAAIANAV
FDGTGTRVRDLPIKAEKIDW
>A0A0P0MDW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limnohabitans sp. 103DPR2|TrEMBL
MNLNVNGNNVSLDVDPQMPLLWVLRDTLNLTGTKFGCGVAACGACTVHKDGQPIRSCVTP
VSSVTGANIQTIESLGTADKPSALQQAWIEEQVPQCGYCQSGMLMAAAALLARKPKPTDA
DIDEAMTNLCRCGTYQRVRAAIHRAAGAQA
>A4AB70|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Congregibacter litoralis KT71|TrEMBL
MLKLMVNGKSMEADVDPSTPLLWVLRDHLGLTGTKYGCGIAQCGACTVHVDGKAMRSCVY
PASAAEGKAITTIEGLSEDASHPVQQAWVEIDTPQCGYCQPGMIMAASALLAEVPNPSDE
DINQRMTNVCRCGTLPRVREGIHRAAAIAGGDRTAATLNGKKGAQS
>A0A1L5PA42|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium etli 8C-3|TrEMBL
MVELVINGKPLSVDAEVDKPLLWVLREDLGLLGPKYGCGIAQCGACRVLIDGKSTPSCMT
PVGSIAGASVVTVEGLTQSGGMLSVVQQAWIEEQVPQCGFCQPGFIVATTALLEANPRPT
DADIDEAITNICRCGTYPRIRRAIHRAAAMLAER
>A0A7W6XF93|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR48|TrEMBL
MIKVKINGQEQSWDGDPDLPLLWFLRDEAGLTGTKYGCGQALCGACTVIVDKQAVRACIT
SVNDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLMDNPKPSHD
QIRESMSGNICRCGCYQRIENAVHLASTGV
>A0A518DCV5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pirellulimonas nuda|TrEMBL
MPGSFTISVNGADRAVVTDADRPLLDVLREELGLTGTKYGCGEGACGACTVILNGEAARS
CITTIEEASGCEVETIEGLADRQQLHAVQQAFIDESAMQCGYCVPGQIMAAVALLRSAPQ
ATRADVVAAMSGNLCRCCNYSRIRAAVEKASGAS
>A0A1E1FWU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MLTLNINGKDQQLEVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCVT
PAATVANGQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPSPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A0P0RHE5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caribensis MBA4|TrEMBL
MLKRRTFLLGGVGLAGALVVGWSALPPRQRLVGSEPLPVRPGEAALNGYVKIAADNTITV
LMCRTEMGQGVHTGLAMLVAEELDANWADIRVANAPLDQIYNNVESVIGDLPFRPDDDSV
VKELAVWLTRKLARDFGTVMTGGSSTINDLWRPMREAGACARTMLIAAAAGRWSVKAADC
RIEKGIVVHDAGHRASFGQLAMEAARQPLPRNPVLKDPATFQLIGKPLTRIEAASKLDGS
AIFGIDVVPDGLLYASIKMCPTPGGTVRDFDGAAAAALSGVRKVLAVDAYNGGTGGVAVI
ADNLFIAMNALDVLTIHWNDGPTRGLTNAEVDRRLVQALDESEGHAWYRHGDVEDALNRA
AHTLKATYRAPYLAHAPLEPVNCTAQVKDGKATVWAATQVPAVARMHVARLLGIGTDDVD
LQQQMPGGAFGRRLEVDFIAQSVAIAREADGRPVQTLWSRQEDMQHDFYRPACLSRFRAG
LDAQGQLIAWHNTSVSQSVVAKWLARNYRIPDLGLNLDKTVSEGAFDQPYEMPNVWIGQR
IVELPMPVGFFRSVGHSHQAFFIESFIDELAALAHKDPVAFRASLLKRHPRHLAVLQKVA
SMSGWRAPAVWSEKGVRHARGVALHEAFGSVVGQVADVSLEADNTVKVDHVYCAIDCGLP
VNPNLIRQQVEGAIVFGLSAAFKEAITLADGAVVEGLYTQFDVVRMDECPDISVDIMPSK
NHPQGVGESAVPPVAPAVANALFALTGTRSYELPLNMKLYPGGATC
>A0A0P0RCY2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia caribensis MBA4|TrEMBL
MATLNINGQSHTIDAPPDMPVLWALRDIVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PIAAVGDKKITTIEAVGDTPAGKKVQAAWRHLDVVQCGYCQSGQVMQAASLLAQNPNPSD
ADIDAAMAGNICRCGTYNRIRAAVKQAAKEA
>A0A388RP37|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus sp. P-10|TrEMBL
MKLQLKINGKRHAVEAERDMPLLWVLRDYLGFSGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGTVARADITTIEGLSADNSHPIQRAWIVEQVPQCGYCQSGMIMAASALLKEKPAPGP
EDVRAAMTNLCRCGTYPRVERAILRAARASGAGAADERAQS
>Q395Z5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)|TrEMBL
MSRGLIEAGKAGTGVSRRSFLRLGVSLGAAAGGGLLLGFSLPAAGDDARRSVIGGDAAEP
AQPGVFAPNAFVQIDRAGKVTLVMPKVEMGQGVYTALPMLIAEELEVPLSSVTLDHAPPN
EKLFLDPLLGGQLTGGSTSVRYAWEPLRRAGATARTLLVAAAAKQWNVDPATCRAANGEV
QHPPSGRRASYGQLADAAAKLPVPKDVALKKPADFKLIGTPAKRLDSPEKVDGTAQFGLD
VRLPGMLYAVIVNSPVFGGTVASVDDTAAKKIPGVRQVVRVDNAVAVVGDHTWAAKRGAS
ALVVKWNEGAGAKVSTKDLFADLAQAAANGKGAVARKDGDVDKAFANAKTRVDAVYEQPL
LAHATMEPVNCTVHVRGDGCEIWVGTQVPTFARDTVQRLTGLAPDKIAVHNHLLGGGFGR
RLETDMIAQAVKVGKQVNAPVKVVWTREEDVQHDMYRPCYYDRISAGLDANGKPVAWQHR
IVGSSIMARFAPPAFQHGVDPDAVEVAAELPYDLPNQLVDYVRQEPRHVPTAFWRGVGPT
RGTFVVESFIDELAAQTKTDPVQYRRALLGKTPRALNVLDVATKAAGWGGPALPTGQGRG
VSVMHAFGSFFSIVVDVAVDNGEVQVKRVVCAVDCGMVVNPNTIEAQVQGGIIFGITGAL
YGEITIEDGRVVQSNFTDYRMLRINETPPIEVHLVKSGEAPGGIGEPGTAATAAAVSNAI
FAATGKRLRKLPVGDQLKTA
>A0A6M4H8X9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Usitatibacter palustris|TrEMBL
MKISRRQFLSSSSALVIGFYLPFLGGRLANAQAPQPKKVFPPNAFLRIAKDNTVTIQIKH
LEFGQGVQTSLPMLIAEELECDWSKVKTELAPAAAVYGNISWGGMQGTGGSSSVSNSWEQ
LRTVGAQARTMLIQAAADAWKVKPADCRAEKGFIVGPGGKRAPFGQFAEAAMNLPLPEVK
LKDPKDFKLIGKPVKRLDSADKVAGKTIFGMDVKRPGLLTAVVAHPPVFGARVKSLNADK
VSRSIGITHVVQITNGVAVVGKGYWPAKNGRDQLDVTWDGGAKTSTEDLLAEYRELAKKP
GLSAKKAANPEAIKGATQTISREYVFPFLAHAPMEPLNCTVEIKGENAELWVGSQFQTMD
HLAAAKTLGLKPENVKLNTTYAGGGFGRRANPASDYIVEACEIAKEVKVPVKVVWSREDD
IRGGYYRPMYLHKVDVGLDASGKIVGWNHVIVGQSILGGTAFEAFLVKDGVDSTSVEGVS
DTHYDIPNLDVSLHTTKSAVPSLWWRSVGHTHTAFVMETMIDEIAAATKKDPVALRRELL
AKNPRFLKVLELAAEKGAWGSAPPAGRAKGFAIHEAFGTVVAQVAEVSLEGGAPKVHKVT
AAMDCGLVVNPLTVEAQVQSAIGFGLSAALMSELTLKDGAVQQSNFHDYQVLRMSDMPQV
SVHLVAGGEKPTGVGEPGTPPIAPAVANALGTLTGRRAQVLPLTKTKWI
>A0A6L5C2W2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas frederiksbergensis|TrEMBL
MNSINNPVSRRGFLKGSAVLGGGLVVAFVIPGAHRFAMGAENQGNVFAPNAFLRIANDNS
VTMLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAKDYGLAGFGGMQITGGST
STWMEFDRYRQAGAAARLMLIDAAAKRFNVAPSEIRTESGVVIAGDKRATYGELADDAGK
LPVPDPASIKLKEAKDWKIIGKPTPRLDTPEKITGRAKFGMDVQFDGLMTAMVARPPVFG
GSVKSFEGAEALAVPGVHKVVQVPTGVAVIADHYWAAKLGRDALKIDWDLGPNSGLDSVK
LLESFRQLAATPGMPASQAGDTAATLKKAAKSIDVEYSVPYLAHAPMEPLNCTVKISADK
CEIWTGTQFQTLDQMVAGQITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAA
GMPVKTVWSREDDIRGGYYRSMFLHQANIGLDADGMPLAWKHVMVGQSIMDGTAFAATMV
KDGVDKTSVEGVADSPYIEGLANHQVELHSPKTGISVLWLRSVGHSHNAFVMESLIDELA
DATGKDPVEYRRTLLKDHPRHLGVLNLAVEKANWNAPLPDGHALGVAVHESFGSYVAHVA
EVSEDNLKIRVHRVVCAVDCGIAVNPQSIAAQMESCVTFGLGFALHSKLTLKDGQVVQSN
YHDYQVLRLNEMPVVEVHIVPSTDKPGGIGEAGVPPVAPAVANAVFALTGQRLRELPLQL
SGV
>A0A841PPL4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sangaii|TrEMBL
MRLTVDGQSFDINADPDMPLLWALRDLIGKTGPKFGCGIAACGACTVHVDGQPVRSCSLP
VSQVSGAVTTIEGIGTADKLHPVQQAWLEEQVAQCGYCQAGQIMSAVALLDEVADPSDDD
IDNAMGGNLCRCGTYPKIRSAIKKAAALKTAGL
>A0A7W8RI28|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. Cpub6|TrEMBL
MMELIVNGVHHNVDADANMPLLWAVRDLLGLHGTKFGCGVGACGACTVHLDGVAVRSCVT
ALADVQGKPVTTIEGLGKGGDHPVQRAWKAANVPQCGYCQPGQIMQAASLLKQTPKPSDE
QIVEAMSGNVCRCGTYQRIKAAIKAAASEA
>A0A840AV82|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingorhabdus rigui|TrEMBL
MTEDAGASEGISRRKLLIGGGAGVGLLVAWGLWPRRYTPNLRTVEGEHLFGPWLKIAEDG
KIVVGVPQSESGQGVYTALAQIVAGELGADWRSVAVQPVPPSPIFANTLLAREWAPAFMP
ENLSLNADGGPVASSINELARRDVFVVTGGSSSIRQFEQPCREAGAAARAVLCQAAAARW
DISWEQCQTDRGFVVFGKKRLAFADLVIEASELAPPSPIPLNSSPRNRLSGRDAPRLDLS
AKVDGSASFAGDIRLPDMLYASVRGGPAGDTRLKSVNTKAALKMRGVVQVVRTKSWVAAV
ASNWWAANTALDAMKPVFATKGGLADSQKIGQSLNDAIAKGPGFRAFKSGDVDAAMAPET
ATRIFKADYSVGAAVHAPIETRSATADYRNGRLQLWIASQAPQAARVAAANAIGIDVNDV
VLYPVMAGGSFDRNFDNVIAAQVAVIAKEVGRPVQLVWSRPEDFLRDHVRTPALGRLSAA
INAEGAVTAMSVRVAAASSMRELANRIDGQSADAARKASAGEFDALAVHGAEIPYAIPNL
TIDHFPVRMPVPTGPWRSLANSYNCFFVEGFIDELAQKAGVEPLSFRMQMLVGQTRLARC
LTGVANMAGWDGGGSGSGRGIACHSMRGSHIAVIVTARTSETGVRVDRIHAMADCGRLIN
PDLARQQIEGGIVFGLAQALGSTTEYQNGMPTARRLRDVDLPKLADVPEITVEFARSDAA
PGGVTELGVPPVAPALANALFSAAGIRLRELPLLSRGL
>A0A7X6BAL4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis italica|TrEMBL
MTRFSVNDRPVEYRMDPETPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGEAIRSCLV
TIAECEGRFVTTIEGLSRDRSHPVQQAWVAEQVPQCGFCQSGMIMSAAALLRANSNPSDA
EVDAAMTGICRCGTYPRIRTAIRLAGRVIRGEERIAAAPPPGIRPEDAARAVPALRPPRG
S
>A0A7X5XVH3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis italica|TrEMBL
MAGIRDTVGKNKSRRPQVSRRQILVGATAAGGLAIAWSLWPRDYQPNLTAAPDEHIFNAF
LKIGDDGHISAIVPQCEMGQGVTTLLPQIMADELGADWRTIAVETAPISPLYANTLLVDE
DSAVFTPRAGVPDFVSEVRSWARREWAVRNAVMLTANSSSVRMFEGPCRAAAAQARALLM
MAAADRWDADWQACDTQDGFVLHGKQRLRFGEVAAAAALLDPPAEPVYRASSADPLYGKE
LTRLDLPAKIDGSANYAGDIRLPDMVFAAIRQGPLGATRLKTIDRKRGMASPGLLHVVTH
DRWVATVARNWWAANGALDRFAPVFETAGIPISSDSIDAALKAALKDDGYRIASEGDVGE
AMDGRTRIAAEYAVAPALHAAVETRTATAAPDRDGLRLWVATQAPAQCRDAVARATGLAP
ANVTLFPMMAGGSFDACLDHSVAVQAGIIALQVKRPVQLAWSRAEEIMRLPPRAPARAKL
TATLNAAGGIDALVTRIAVPATNHEVRARLFDNQPADEAQRAATGRADAAAVEGAMPRYA
IPHHAVDHCPADIGLPTGRWRGNADSYTAFFTECFIDEMAARAGSDALSYRMAMLGDAPL
LARCLLTATSLGGWEGGLAGSAQGLACHAMRGSHIALMATARQSDKGLQVEQLVAVVDAG
RLVNPAIARQQVEGGLIFGLAAAVGATTDYEGGLATARKLGQLGLPRLSQTPRILVEFVE
SDREPGGLGEIGVPVVAPAIANAMFAATGRRIRRIPLSAHPL
>A0A846UV02|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MSTLNINGQSRQVDADPSTPILWALRDTLGMTGTKFGCGQALCGACTVHLNGQAIRSCVT
PISAAAGQKITTIEAVTAGADKVGKAVHDAWVKHDVAQCGYCQSGQIMSATAFLKTVPRG
TVPTEAEIDSAMAGNICRCGTYARIRAAVADAAKSLA
>A0A846U857|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MPRLHVNGSVREVDAEPETPLLWVLREQLELTGTKYGCGIAQCGACTVHLDGVPTRSCVR
PVSTVGPDEKIVTIEGLSANATHPAQKAWAALDVPQCGYCQSGMIMAAAALLKAKPRPSD
ADIDDAMTNICRCGTYNRVRAAIKAAAQGGDPKQAGLHIVHIDGGKA
>A0A6S7BJR4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Achromobacter animicus|TrEMBL
MTQLQINGQTKDVNVPDEMPIIWVLRDELGMTGTKFGCGMALCGACTVHIDGTPVRSCLT
PVSVATGRQLSTIEGMEADPVGRAVQASWVTNNVAQCGYCQAGQIMTAVSLLKATPNPTE
QQIADAMSGNICRCGTYPRILAAIQQAAARLAQGSKQ
>K6ZAL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola arctica BSs20135|TrEMBL
MSVSKQNTVSNESRRKFLKQSGLATGGLVLGISLPQTTIAGFKMGEDSTFNPNAFIHIAD
NGDTLIYCGRCEMGQGISTALPAAVADELEADWTRVNIKQGEGNEEKYGSQATGGSASIR
TMYIPMREAGAAAKVMLVAAAAKVWGVPAQDCMADNHFVINKNNQQKLGYGELASLAANE
QVPASVTLKEKKDYKYIGKDIARHNQGDIVVGKLTYGVDTKMPGLKYAAITHCPVMGGKL
KSVDKTAAKQVKGVIDVIEIPRFEVPFGSLGGVAVVADNTWTAQQALKKLKIEWDLGEHQ
SYDTKAYKAQLVKNVESPAQLAAERGDITKAFAEAEHVVKATYTGGHLSHSPMEPNASVV
WVQKDSCEVWAATQSPADIQKVLGQYLKREPKDIFVNVTMAGGAFGRKFKCDYVHEAAVL
SQAVNAPVQLTWSREEDMRTGYYHSINAQHIEAAVDKDGNVTGWLHRAAFPAIASLFDPS
LDRAPANNLGDVDNHPFGIANYRSETGEAKAHTRIGWYRAVYAIFYGFAFGSAADELAHK
TKKDTVSLLNSIYDNNKNAEQAEQVARSKGALAMAAKMSNWANRDKLPKNQGLGIAVHYS
FNTYVAMAVRVEVNGEDIKVLEVDAIVDCGQVLNTDSATAQMEGAVVMGMSLSLRTEVVF
RDGAVVNSNFHNYPVLRINEMPQVNVHFMENDYKPTGLGEPGLGPFAPALANAVFAASGK
RYRDLPFKPMSM
>A0A840GXS4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. ERR14|TrEMBL
MIKVKINGQEQSWDGDPDLPLLWFLRDEAGLTGTKYGCGQALCGACTVIVDKQAVRACIT
SVNDVAGREVTTIEGLHPTGDHPVQKAWRQVNVPQCGFCQAGQIMQAAALLMDNPKPSHD
QIRESMSGNICRCGCYQRIENAVHLASTGV
>A2SLZ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)|TrEMBL
MDLLINGRFVPLPDEAVDPAMPLLWVLRDVLQLTGSKYGCGIGACGACTVRLDGVPARSC
VTPLSAVGGRAVQTIEGLGGADRPHALQRAWVLHQVPQCGYCQSGLLMAAAALLERQPKP
SDADIDAALTNLCRCGTYPRVRAAIHTAAAALAAPRAATPPPPKRAP
>A0A7W7L972|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces netropsis|TrEMBL
MPSHTFTVNGRSVTVDAPDDLPLLWALRDLLGIRGPKYGCGIDVCKACTSHLDGEAVRPC
VVPVAEAAGRDVTTIEGLADGDTLHPVQEAWLEQDVAQCGYCQPGQIMAAVALLKRTKNP
TDADIDAIANVCRCGTYFRIREAIHSAAAKMA
>A0A0M6ZUM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseibium album|TrEMBL
MSVTLKINGETRTLDADPESPLLWALRDELGMTGTKFGCGIASCGACTVHWDGVPIRSCQ
TFVGDLEGAEITTIEGVDGKAAQAVQAAWNELDVPQCGYCQSGQIMAATALLSETPKPTD
EDIDAAMDGNVCRCATYARIRKAIHLASDKMEA
>A0A1Y0XUM3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter pasteurianus subsp. pasteurianus|TrEMBL
MGKLERIAARQDRAAGRGPTRRGFLLTAMGSAFMFGFARQGNAAQVYPQAAGNLPAGGVF
EPTIWCSIAPDGWVNVNVIRAEMGQHVGTALARIIADEMEADWNKVKITYVDTDPKWGLM
ITGGSWSVWLTWDQFRQAGAAARTVMVEEGARLLGVAPSACIARNGQVIAGKRSISYGEI
VSRAHPTRTFTPDEMAKLPLKPSSEHRLIGREVKALDIPSKTDGTAIYGIDAKLEGMVYA
RPKMPPTRYGSKVVSVDDTEAKKVKGYIRYIVLDDPSNTVPGWVAVLASSYPAAIRATDA
LKVTWTPGKTANVTEQDIIEHGRKQIAEKTGGSRIFNDAGVDEALGKADKVVERTYTCSS
VLHYQLEPMNALARLHEGKWEVHCGNQWQTLFLPVIAKALQVPESDVVMRSYLLGGGFGR
RLNGDYAVPAALISKALGGKPVKLVFTRSDDVLFDSIRSPSIQTVRAGVNKDGSINGWEH
HASAGWPTGVMAAAFMEKGEDGKPYDQFAIAGADHWYDVGPILVRALDNDLADATFRPGW
LRSVSSGWTPWAHESFLDELAHDYGKDPVDFRLGLLTCKGRNAGSAPNSVGGASRQANVL
KKLVEKCGYGKVSLPKDTAIGIATTFGQERNMPTWTAGAAQVHVDRETGVVTCQKIWLVL
DAGTIIDPDGALAQTEGGALWGLSMALFEGTEIENGNVRDRNLNTYTPLRITDVPDMDIE
FLPSTEKPMGLGEPGVTTIAPAIGNAIFNAVGVRMRHLPVRPADILKALKEKGNA
>A0A1Q9R5G3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas putida|TrEMBL
MSTEQLPLGEPVNLSRRRFLLASAGAAAGALVIGCGLPLGISRVEAAETAAPGIKVPALL
EIRPDGRVRLLCSFMEGGQGIYTAMAQIVGEELDVDPAHFIVEAAPAGPAFVVMDNGLRI
TGGSMSVRTSYPTMRKLGALTRAMLLQAASERLKVPVSELTTEPGRVIHASSGRSLGYGE
LAERAMDLPVPNADSVPLRDPSQFRWIGKPVQRVDAYDKSTGKAVYSIDIKVEGMLHAAV
QHAPRLGMTVGSVRNEDQVKAMKGVHSVHRLPGAMAVVAERWWHAKRAAEALQVDWQEAG
PDSKLRPMPADFSSDGHRERLAAETGPGREAEKEGDFASAWSKATTKVEATYHNQYLNHA
QLEPPSATARFNPDGTLEVWLPNQAPDMFRADIAKRTGLDPEKISLHSPLLGGFFGRHFL
YESANPYPQAIELAKATGRPIKLIWSREEEFVRDALRPMAVVRFRAALDQDGLPVALEAV
SATEGPTEAIAGKQGEKIDNTAVEGLAGKAYAIANRRIAQNYVKGPAMLGYWRSVGNSLN
DFFYEAFLDELADQGKHDPFDLRLKLLRDNPRLTTLLKAVGELSGGWKRGPYIAEDGTRR
ARGVAMASPFGSEAAVIAEVSIEHGQVKVHEIWQAIDPGSIVNPAIIDAQVNGAVALGLS
QALVEEAVYIDGKPRARNYDLYPILPPARMARVHVKIIESGAKMGGIGEPPLPATAPAVA
NAVAHLTGQRIRSMPLSRYNFS
>A5EEJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)|TrEMBL
MTPATIRLTVNGQTHDVTAAPDTPLLHALRNDLGLNGPKYGCGLGECGACTVLIDGRAAR
SCVIPIEGCVGRTVTTLEGLGSREAPDPVQQAFIAEQAAQCGYCLNGMIMTTKALLAIKP
DPSLDEIKQALRYNLCRCGAHIEILRAAMRAAGHALEALD
>A0A840RPQ4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Glaciimonas immobilis|TrEMBL
MTILNINGKQHNIDLPADTPILWTLRDDIGLTGTKFGCGMALCGACTVHLDGAPIRSCVT
PISAAVGKKITTIEVIANDSVGKAIQQAWVALGVPQCGYCQAGQIMSATALLKTTPKPTD
EEIDNAMSGNICRCGTYTRIKAAIKQVAANNGVAK
>K1KUH5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cecembia lonarensis LW9|TrEMBL
MEKFTLIINGNKQSVEVQPDMPLLWVLRDILDLKGAKYGCGQGLCGSCTVLLDDVAIRSC
AYPVSEVGDQKITTIEGLSNEGKHPVQKAWVEHVVPQCGYCQTGQIMSAAALLKRNPKPS
EEEIESAMAGNLCRCGTYNRIKEAILTASKSY
>A0A7X0PBF1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acidovorax soli|TrEMBL
MHFEPHTVQAHMPRHLLALLESVQDAPAEPAQGLARRSFLKVTAATGFALGAFPLAAVAQ
GAAAPAGGLKPFEQPSAFVRIEPDGTVTVTINRLDFGQGVQTGLPMILAEELDADWSKVR
STHGDANPAYADPAMGMHLTGGSNSIKNSYTQYRELGARTRAMLVSAAAAQWGVDASTLR
TQSGFVVGPGGKKLGYGELAEAAMKLPVPEKVTLKDPKQFRLIGKPTGRLDAKAKASGQQ
GYGIDVRLPGMLTAVVARPPVFAAKLKSLDDSAAKAVKGVKAVLRVPVDRGGEGVAVVAD
GYWAAKQGRDALKVEWDTAAVEKADTVQMLASYRELAAKPGLVAMQADTAPLANAPHRIS
AEYVFPYLAHAPMEPLNCTVQLVGNKAELWMGTQMPGLDAVAAAKALGLQPQDVKIHTQM
AGGGFGRRGVPTADYVVEACAVAKAAGAAGLAAPVRTLWSREDDIKGGYYRPMHVHRAEI
GFDAQGNVLAWDHTIVGQSILKGSPFEGFMVKNGIDATAIEGMKEPYDVPMKLSVHHPQV
NVPVLWWRSVGSTHTAYAMETLIDEVARTTKQDPVAYRLRLMGDKHPRHKAALELAVAQS
GYGKKKLPAGRAWGVAVHVSFQSVVAYVVEASVTKDGAPKLHRITAGVHCNLAVNPKSVE
AQVQGGALMGLSMCLPGGAVTLKDGVVEQSNFGDFAVPRITDMPQVAVHIVPSAEPPTGM
GEPGLPPLAPAFANAIAQLTGKTLRELPFKMA
>A0A7W6ENA5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella defluvii|TrEMBL
MQLSLTINNKPTVLDVEPDMPLLWLIRDEAKLKGTKFGCGKALCGACSLYVDGDLIRSCS
YPAQLANGKKITTIEGLSEDEAHLHPVQQAWLEVQVPQCGYCQSGFMMAAAKLLEENPNP
TTDDIKNGISNICRCGTHPRIIKAILLAAKLKNDGKRG
>A0A0P1IMG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shimia thalassica|TrEMBL
MASIGKIARRSFLIGSAAVVGGVAFGVYKVKTPYENPLEDELASGATTFNPWVVIDGDKI
TLIGSHGDKGQGVAHSQATLIAEELDLEFGQFETSFGQPDKAYWNTALADEGVPFPSTDD
GFTAETMRGIMGGVVKLMGMQITGGSTTIPDSFDKLRRAGAIARETLKAAAAQKSGINTT
ALKTEAGHVILPDGTRLSYQELAPIAAALDPVTDVALRDPGQWRLIGKPTQRIDMVAKST
GTQTYGIDLDIPGQVHAAVKVNPRQGGAMKGYDASAATDMRGVSNVVEITGGVGVIADNT
WRAIQAVNAIDFDWGEAPYPAEQDQHWEEIGKSFVDDRLDKKWRDDGDTDAALAADTPLN
AEYRAPYVAHAPLEPLNATVLVEEDGVTVWAGHQIPRQLQVLVAQITGHEAEQVTFVNQF
MGGSFGHRLEFDNIKQATEIANQMRGTPVKLTYSREEDFAHDYPRHIGMARGAGTVKDGK
VEAIDLQVAMPSVIESQMGRAQMPVPGPDSQIVAGAWNNPYALPNYRMRGYRVPQLAPVS
SWRSVGASANGFFFDSFLDELIHEAGADPMEERIRLMGHETSRKVLEAVAEMSSWGGALG
PNKGRGVAFVESFGVPTAEVIEVTNTEDGIRIDKVWVAADVGTVVDPVNFENLVQGGVVF
ALGHAINSEITYADGMAEQANYWDAEGMRLHQCPEIFVKGLEHGAKVRGIGEPPVPPAAP
ALANAIFAATGRRIREMPFNKHIDFV
>A0A1U7DCH6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MVSFELNGKQVSVDVPDDTPLLWVLRDELRMTGTKFGCGVAQCGACTVMMNGMTRRSCVT
PISTVEGSYVTTIEGVDGPEAKAVQEAWEGLDVPQCGWCQSGQVMSAAALLREVPKPSDE
DIDNAMAGNVCRCATYVRIRQAIHDAADKLEG
>A0A021XGN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shinella sp. DD12|TrEMBL
MDIVLNRQPASVPDDLADEPLLFLLRDHFGLNGPRFGCGVGSCGACTVIIDGEAQRSCLL
TAGAVDGRTILTLEGLAADGKLHPLQESWIAESVPQCGYCQNGQIMTAHALLSAHPAAGP
DTIAEAMDGVLCRCGTQARIRRAIARAQTIMQGET
>A0A2S2DYR7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aquirufa nivalisilvae|TrEMBL
MKKQSHISRRSFLQSAALSGGGFMLSFTYFSSFASSGKTVQSGVATQYEINGFVKITSDN
IIQIMSPNPEGGQGVKTSMPMIVAEELDVNWKQVQVIQADLDTKHFTRQYIGGSQAIHQG
WKPLRQAGATARHLLMEAAAQQWQVPIQEISTSAGMLFHKKSGKSAKYGDLASLAATLTV
PQNIALKEVKDFSIIGKSKTNVDLKKIVTGKPLYGIDTQVKGMLYAMIVHPPAFGLELKS
INDSEARKMPGIKDIFPIKIFNEGYEKTFFDTASFNEVVAIVGNSTWEVMQAKKVLQVNW
QETKAYSQPRNMLGRKIVENVPAGLESTTVHAANMAAKKDQAATVRRKDGDVESAFKNAN
KVIEKTYYGPYLAHNCMEPMNFFADVKKDSAQLAGPLQKPELTEQALSARIGLPLDKINI
QMTRLGGGFGKRSYAHWMIEAALISQKVQAPVKLLYTREDDMTSGVYRSTYSVTYKAALD
AQNNLIAFHVKAGGIPESPLYPNRFPAGAVDHYLAEEWTIDSNITVGSFRAPRSNFMAAA
EQSFLDEVAELAGKDPIDFRLELLKRAADKPVGKNNEYEPERYAGVLKLVQEKSNWKNIK
STKKVGVSAYFCHDSYAANVIEIKMKDGMPVIEKVHCAIDCGIVINPTGAQNMVEGGVVD
GIGTALFGKMTLEKGVPEHKNFDTYRMIRMNEAPKAIAVHFVKNEIDPSGMGEPAYPPVF
GALANALYRATGKRHYSQPFIDNL
>A0A1U7DCK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MTKQLSRRNFLASSAGLVIGMSLPLAARAQSGAAAALESGATDDAGFAPNAFVRVAPDDT
VTVIIKHIEFGQGPYTGLSTLVAEEMDADWSQMRAESAPANNELYKNLAFGMQGTGGSTA
MANSYMQMRKAGAAARAMLVAAAAEEWGVPAGEITVEKGRISHGSGKSSGFGALAQKAAG
MTPPEDPQVKSADQFTLIGTDLPKLDTRAKTNGTATFSLDVYREGMQTVVVARPRKLGAT
VASFDDADAMNVTGVRAVRQIPQGVAVYADSTFAAISGRNALKIEWDESGAETRSSDQIY
ADFAKAAEDGGQDAEMLGNGAADIEGAAQVIEAEFRFPYLAHAPMEPLDGVIEVREDGAE
AWMGSQFPALDKPAIAKALGLDAGAVAVNVMLAGGSFGRRAQDTAHFASELGEVAKAGGP
GTYKLLWTREDDLHGGYYRPLTIHRMRAGIDGDGNLLGWEDVIVNQSIMAGGPMAQMMQD
GMDPTSYEGSTKMPYDLANARVGWVQQESPVTVLWWRSVGHTHTGYATEVFLDMVLEAQG
KDPVQGRLDLLKSDRGRDRGVLEKVAEMAGWDGTRVKGDKAYGVAVHESFETYVAQIAEV
SDEGGMPKVHRVWCAVDCGVAVNPNVIRAQMEGGVGFGLGTVLFDEITLGEGGTVQQSNF
DSYRMLRIHEMPEVTVEIIASDADPTGVGEPGLPPIGPAVANAWRALTGKSVTTLPFSKS
AEA
>M4UGV7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum FQY_4|TrEMBL
MTADATAPRRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQPGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLTAEELDIPLARVRVESAPIERIYGNVVSVVDSAL
PLHPDDAGKAWARALHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
RAWNVQAAQVSVHDGRLIGPGGRQAGFGEVAAHARDIAPPASVTLKPASQYRLVGQPAPR
SDAAGKTDGSARFAIDVRPPGLLYAAVAMCPVFGGRLKAFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLEPVWDSGPHAALDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVGGATVVEAEYSVPYLAHAAMEPINCTAQVTRDHVQLWAPTQVATLAQLV
AARAAGVRREQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIERGRVTALASRSAGQSILAGELGRLFGAPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEVAAAAGLDPLAMRRDLLEAHP
RERTVLDTAARAAGWGQPLAPAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPGIVARQVESAVIFGLGAALHGQIQVKDGQVVQSNYSDYPVLGMADTPV
IETHLVPSAAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A7W9B0P0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Brucella daejeonensis|TrEMBL
MKLQINNQFHDVHSDGDTPLLWVIRDELGMTGTKYGCGLAQCGACSVMVDGEITRSCVTP
LESVEGRSVTTIEAIESDPVGKAVVAAWIAHQVPQCGYCQSGQVMAATALLKQTPKPTDE
DIAAAMVNLCRCGTYNAIKAAVHDLADQKVDTL
>A0A0N7LY34|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Thalassobius autumnalis|TrEMBL
MKLIVNGTERQVEVEDDMPLLWILRDELGITGVKYGCGIAACGACTVHVDGEAMRSCQVT
ADTLEDGMEITTIEGLGTPPALHAVQSAWVEHQVAQCGYCQSGQIMQAAALLAEIPNPTD
EDIDDAMSGNLCRCGTYPRIRAAVKTAAQTLQEA
>A0A839DZK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Halosaccharopolyspora lacisalsi|TrEMBL
MPEHTFTLNGEQVTVDVDGDVRLLWAIRDLLGVTGPKYGCGINVCKACTCHINGKAFNPC
SVRVADVGPDDEITTIEGLPTTVGEDLHPMQQAWLDHDVAQCGYCQPGQIMAAVAKVRQA
RAEGHEVRDEDLDEIRNICRCGTYNRIRDAIRSGAEHM
>A0A3B0ZY25|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MDKITVNNKIINLDVEPDTPLLWVLRDNLGMTGTKYACGKGLCGACTVLIDNKPVRSCIT
PVINIKDKRVTTIEGLAEGLLQTVEEVWTETGASECGYCQPGQVMSALALLIKIPQPTDM
DIDKAMSGNLCRCGIYQRIRKAIHRLASIGIPKKIHNG
>A0A7W6DAN5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium azooxidifex|TrEMBL
MKKLTINGQVHDVDVPDDMPLLWVLRDVLGLTGTKYGCGIAQCGACTIHLGGVAVRSCQT
TMDMVEDIPITTIEGVGDTPIGAKVQSAWLEKEVVQCGYCQSGQIMSATALLTDNPRPTD
TDIDDALAGNICRCGTYVRIREAIHSVTV
>A0A7X0AYS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nitrospirillum iridis|TrEMBL
MPPIKLTLNGKPWSVDADPDMPLLWAVREIAGKTGSKFGCGAAQCGACTMHVDGQPVRSC
STPIGSIAGSKVTTIEGLEGKVAKAVQDAWVKLDVVQCGYCQSGQIMSAVALLTDTPKPT
DQDIDSAMSGNLCRCSTYVRIRAAIHEAAKALEI
>A0A0N8KKK6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter excellens HL-55|TrEMBL
MTMNRRDFLKVSTGASGSLILAVSIPGCASIQTGFEPESGEWKPDVWLELSRDDDIVFTL
ARVEMGQGAYTGLTTLIAEELDVDPARIIVKFAPVAPEYRNPLFGLQLTGASTSLATSWK
PLREAGASARQMLVLAAARVWEVNASDCTTQDGRVVHPNGIDSLRYGQLVELADKEVIRG
DVALKPKSEWKYIGRQAGKLDAHAKVTGKAVYGIDVELPDMVYAVMTRSPRHGGVAKDFN
RRDVIGLPGVQDAFITERGVAVVANSYWQARKAQQALQVDWDMTGALDTSTEQVLEGYRR
AASDDPGVKERTEGSVNKAAEQAEKVVEAEYEQPYLAHATMEPMNATAWYHDGQMEVWAP
TQAPDLGRIAAARHSDLSPGDVTIHTTFLGGGFGRRLTQDYIEEAAAVAYQLKVPVKLIW
SREEDTRHGFLRPAMLHRMKGSLAEGQLTGWQHQIVGPQILDWYVRNAAPAQYPWAPKFL
YDTLGKVGLMAEGIATPKDISAIEGAVGYPYQVPNISVRHTHTDPGVPITWWRSVGYSHN
GFAVETFMDELAHESGEDPVQFRQRMLDSEPRHREVLERAARLAGWGESAPEGRARGMAL
FKSFGTYVAQVVEAGVENGEIKVYKVTCSVDCGQVVNPRIVEDQIAGGILFGLTAALYGE
INFDQGEIRQSNFHDYRLLQLHQAPKVVVDIVDSNAEPTGVGEPGVPPVIPALGNALFAL
TGKRQRRLPLTA
>G2ZW33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|blood disease bacterium R229|TrEMBL
MELDVNRRPVKVECDPATPLLWVLRDHLHLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
VVAVAGKRITTIEGLAEVPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
ADIDAAITNLCRCGTYPRVRTAIQRAAKALREGRA
>A0A7W5S5A9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK481|TrEMBL
MISRRGILAGGGVGIGLVVAWGLWPRDYAPTLVADPGESAFGAWLKIGSDGHVTVAVPQA
EHGQGVYTALAQIVADELGADWRTVGVEPAPLNPLYANPVGLNALFEGMPGVVPAAVAGP
APTLTAGSSSVRMFEAACRSAGAAARVLLCKAAARRWDADWADCRTEAGFVVQGARRIRF
AALAEDAARETLPDEPVIGGPGAGALAGRSVPRIDTPAKVDGSANFTGDVRLPDMVHAAI
RQGPVGDSRLIGVDRAAADRVRGVLQIVETPAWVAAVATTGWAAQQALSAMAPRFATRGP
LVDSGTIAAALDAAFETPGATMAQTGEIGTLLDGAGVVTAAYRVAPAVHAAIETRSATAA
YRDGILELWMQTQAPGPARAAAAAAAGIDEAQVVIHPMPVGGSFGAALEHDAAAQAAVLA
VRLKRPVSLVWSRAEDLMHDRYRPAAAARLAARLDARGRILAWRTAIAAPATGAEIAARV
LPGIASRAATALTRGDPHAVGGALPAYAIPAVAVVHHAAEIGVPTGALRGGAHGYTAFFT
ETFVDELARIAATEPMSYRIGMLGGGARLARCLSTAASLGGWNGGVPGSGQGIAAHAFRG
SFIAVLAEAHLGADRRPVVERLVAAVDCGVQINPDLVRQQIEGGLIFGLATALGAATGFT
RNLADARGFGDLHLPRLADTPDITVELIRSDEAPGGVGELGVPAVAPAIANAIFSATGFR
LRDLPLRPST
>I0K698|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrella aestuarina BUZ 2|TrEMBL
MAVFKLTINGRTHQADVEADTPLLWVLRDHLGLVGTKYGCGIAQCGACTVHVNGEATRSC
VLPVSAIGAGKVVTIEGLSAKGDHPVQQAWNEVDVPQCGYCQAGQIMTAAAFLKRNPKPA
AADIDSAMSGNICRCGTYHRIREAVQLASTKLKK
>A0A1Y5U1C8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseisalinus antarcticus|TrEMBL
MELTINGTSHSVDLPDDMPLLWALRDGLNITSVKYGCGIAQCGACTVHIGGEAVRSCQVA
LADVWGEITTIEGLGTPDALHAIQAAWIDHQVAQCGYCQSGQIMQAADLLSRNPEPTDDD
IDAAMSGNLCRCGTYPRIRTAVHAAASAMREV
>A0A839YJL4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK580|TrEMBL
MAALTRRKLLISGGAGVGLVVAWAVWPRQYGAALPTAPGEAAFGPFLKIARDGQVIVAVP
QCEHGQGVYTTLAQIVADELGADWRTVGVEAAPLAPPYANPIGAAALFADAAAHVPERVR
DELWTRDSLLVTAGSSSVRRFEQPLREAGAAARVLLCQAAAERWDADWQQCDTRAGFVTL
GERRLRFAELAEAAAAGRVPDELPLRLGDEGRLSGESLPRLDSPAKVDGSANFVADVRLP
DMVFASVRQGPQPGARLLSCDRAAAERVRGLLSVVTTDHWVAAVANDWWSANQGVIALAP
RFARSGTMVDDAAIERALDAALDRAGEPVARAGDAAAALRGAGVIAAEYSVRPALHAALE
TPAATAHWRDGRLELWLATQAPTLARAAAARAVQLSERDVIVHALQVGGSFGAALEHDVA
AQAAVLARALRRPVQLCWSRGEALLQDRVRAPAKARMRARLGPRGTILAWHAAIAAPPTG
RALGERLLAGDPLRRVAAALPAGADRYATSGAVPPYRLPALAVDHHPVALDLPTGHLRGG
ADGYTAFFTECFIDELARAAGSEPMSYRVGLLGGDARLARCLTTAAELGGWSGGVPGSAQ
GIACHRLAGSAIAVLAEAEAGEGGAARVSRLVAAVDGGRAINPDVVRQQIEGGLVFGVAA
ATGAAAGYQDDLATVRHLGALELPTLATAPEISVELIASGADCGGISDLGVPAVAPAIAN
ALFAATGARRRALPLRSS
>A0A221JXJ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter pseudonitzschiae|TrEMBL
MKLTVDGTAHEVDVEEDMPLLWVLRDELGYKGVKYGCGVAQCGACTVHLDGVAVRSCQTW
AADAEGAEVTTIEGLGTPDALHAVQEAWITHQVAQCGYCQAGQMMQAAALLAETPAPTDA
DIDEAMSGNLCRCGTYPRIRAAVKTAAANLSEV
>A0A0S3PYL0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variibacter gotjawalensis|TrEMBL
MAKLNINGKVQDVDLDPDTPLLWVIREQIGLTGTKYGCGVAACGACTVHIDGAAVRSCAM
PVSAVSEDQKIVTIEGLSPDSSHPVQKAWLQLDVPQCGYCQSGMIMASAALLAQKPKPTD
EDINAEITNICRCGTYNRVRAAIKLAADTKAG
>A0A508SUX6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium ivorense|TrEMBL
MTLTNLSERAAELSRRNFLRATAVAGGGLLLSVSLPLAGGDGALAASDNFEPNAFVKIGG
DGRIVLTMPYVEMGQGTYTSIPMLIAEELEVELKQIQLEHAPPSDKLYANPLLGVQATGN
SNAMRGSWQPMRKAGATAKAMLVAAAAKRWEVDPASCRAEKGEVLHAASGRKLGYGALAA
DAAKLPVPEQVTLKSPADFKLIGTPAKRLDTPSKINGTAMYGIDARPPGVKVATLAQSPV
FGGKVKRVDDAAAKAVKGVRQIVQLDDAVAVIADHMGAAKKGLAALTIEWDDGPHAKLNT
ADIARELEAATTRPGAVAQNVGDADKAMAGAATRVESTYQLPFLAHATMEPMNCTVHVRA
DGCEIWLGSQALSRAQAVAAKVLNLPPEEVVVHNHLLGGGFGRRLEVDSVIRAVQIAKQV
DAPVKLVWTREEDIQHDMYRPYWFDRISVGLDAAGKPVAWNNRFAGSSVLARWAPPVFRN
GLDPDTTEGAIDLVYDIPNFHVEYVRVEPPGIPTAFWRSVGPSHNVFVAESMIDELAAAA
KQDPVAYRRALLGKSPRAKAALELAAAKAGWGEKLPAGRGRGVSLQFVFGSYLAQVAEVE
VAKDGSVRVHRVVCAMDCGTVVNPNTVQAQLQSGINFGVTAALYGEITLKDGRVEQGNFD
SYQMLRIDAAPAIEVHIVPSTEPPGGMGETGTSGIVPAISNAIFAATGKRLRKMPIDPAL
LKQA
>A0A1E3H4S9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobrevis pamukkalensis|TrEMBL
MIKLTINGAEREIDVADDTPLLWALRDDLQMTGTKFGCGAGLCGACTVYIDNVPVRSCQT
AVGDVGTSAVTTIEGLSGKAAQAVQAAWVEIQVPQCGYCQSGQIMAAAALLTETPKPTDE
DILNAMDGNACRCATYARIHAAVKRASDMMEG
>A0A7W6RXJ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseospira goensis|TrEMBL
MVRLKINGSVQELDIPSDTPLLWALRDTLGLVGTKYGCGITQCGACTVHVDGQAVRACQT
YVGDLVDAEITTIEGLSGPVADAVKTAWIAADVAQCGYCQPGQVMQAVALLAREPAPDDD
AITTAMNGNLCRCGTYDRIRAAIHAAAGALGTAAADTAPAEKG
>A0A839P2K0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacterium sp. R2-1|TrEMBL
MNDLTPLRRVGIGARHDPEPVQNLSRRGFLGVATGALLLGVGLPIEAAAQTRAEGPAAVA
PKPGTRVAAFLEIRPDSSVRLLSPFVEGGQGINTGLAQTIGEELDLDPARFAVECAPPGP
DYAVVNGLRMTGGSFSTRSSFEAMRRLGATAREMLLRAAAARLAVKQDSLTTEDGRVIHA
ASGRTLGYGELAEAALALQPRDDVSLKDPKDFRWIGRPVARLDRRDKATGRTTYTIDIRL
EDMLHAAVQHAPHLGAEPQAIANEAEVRVMAGVHSVHRLPGAVAVVADSWWRARKGAEAL
QVAWTEPVPDGIATVSKTFSSSAMLAALKGANEPGIPAEREGDPAAAFAGAARVIEAEYD
APYLAHAQLEPPSAVARFTPDGSLDLWLPNQMPELFQDIAAKTAGLAPEQVRIHSPMLGG
FFGRHFYYGPANPFPQAILLARATGRPVRVLWSREEEFGMDAVRPLSFARFKAALGADGM
PVALQTTAVGEGPIGRWFGALFKSPVDSSVVEGLDKKPYAIPNRRLDYVKVAHPVTIAFW
RSVGHSMNDYFYESFLDEIAAAGGHDPFDLRVALLKDSPRHRTLLRAVADLAGGWRRGPF
AAEDGTRRACGVSMASPFGSETATIAEVSLKDGEARVHDLWIAIDPGSVVNPAIVKRQVE
SAAALGLSSTLLEQVVYENGQRQAKNFDTYPILDRERMPRVHVTIVESGAPMGGIGEPGL
PGVPPAVVNAVAALTGQRVRSLPLAKTHLSGV
>A0A5E6XYE3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACIT
PATAVAHGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPNPTD
SDIDQALSGNICRCGTYPRIRAAVKRASEIG
>A0A5E7FQD0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRACVT
PATAVAHGQKILTIEGLSTDGSHPVQRAWAELDVVQCGYCQSGQIMSAAALLAKIPQPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A5E7L6X7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGKDQELDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGTPLRSCIT
PATAVAHGQKILTIEGLSLDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
TDIDQALSGNICRCGTYPRIRAAVKRAAELG
>A0A5E7MFB6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRVPNDFALSNLSRRGFLKGVGATSALVLAASWGWQDALADDAAKKFGADGMPNGWIDD
PKVYVSIAADGSVTVVCNRSEMGQGVRTSLSMVVADELEADWAQVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAAQWKVPVGECHAQLHKVIHKPSGRELGYG
ELAAAASALAVPARDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAVYGADVHFDGMLYA
TIARPAVYGGKVKSLDDSAALKVPGVLKVMQIEGRPLPSEFQPLGGVAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKAGKVVRNTGDIDKALSGAASTLEASYYLP
HLAQAPMEPMVAIARYKDGVCEAWAPSQAPQVTRERIAERLGVPFEKVTVNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHNSYFHTVSAEYLKAGIDKNGMPSGWL
HRTVAPSITALFAPDMNHEAAFELGMGFTNMAYAIPNVRLENPEAKVHTRVGWYRSVSNI
PHGFAIQSFVDELAHKAGEDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTGRM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGSLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLSNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGDVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A5E7KH62|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSNPPLSRRGFLKGSALLGSGLVVAFVIPGAHRFALGAENQGNIFAPNAFLRIGNDNSV
TVLLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAAEYGMAGFGGMQITGGSTS
TWMEFDRYRQAGAAARLMLVEAAAKRFDVAPSQIRTESGVVIAGDQRATYGELADDAAQL
PVPDPASIKFKEAKDWKIIGKPTKRLDTPEKITGKAKFGMDVQFDGLMTAMVARPPVFGG
SVKSFEGAAALAVPGVHKVVQVPSGVAVIADHYWAAKLGRDALQIDWDLGPNSGLDSGKL
LESFRKLATTPGISASKAGDASAALAKAAKKIDVEYSVPYLAHAPMEPLNCTVKISQDKC
EIWTGTQFQTLDQMIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKVAG
APVKTVWSREDDIRGGYYRSMFLHQANVGLDADGMPVAWKHVLVGQSIMADTSLEASMVK
GGVDKTSVEGVADSPYLEHLANHQVELHSPKTGIAVLWLRSVGHTHTAFVMESLIDELAE
AAGKDPVEYRRTLLKNHPRHLGVLNLAVEKANWGAPLPDGHAVGVAVHESFGSYVAQVAE
VSQDNLEIRVHRVVCAVDCGIAVNPQSIAAQMESGITFGLSFALHSKLTLKGGQVVQSNF
HDYQVLRLNEMPVVEVHIVPSSDKPGGIGEVGVPPTAPAVANAVFALTGQRLRELPLQLS
GV
>A0A5E6SU47|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGHKFAYAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMPAFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKHFEVAPSTIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGATV
KSFEGAAALAIPGVHKVLQVPSGVAVVAEHFWAAKLGRDALKVDWDLGSLADMSSEKLLE
SFRKLAATPGTSATQAGDAKTSFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAGKCEI
WTGTQFQTLDQMVASKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMP
VKTVWAREDDIRGGYYRSMYLHQARVGLGADGLPLSWQHVLVGQSIMAGTMLEATMVKNG
IDVTSVEGVADSPYIKDLAHHQVDLHSPKTGINVLWLRSVGHTHTGFVMESLIDELATAA
GKDPVEYRRTLLKAHPRHLGVLNLAVEKANWGAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLSMALHSKLTVKNGGVVQSNYHD
YQVLRLNEMPVVEVHIVPSSEKPGGIGEPGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>A0A839S2D5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Prauserella isguenensis|TrEMBL
MTTTDGPHTVNRRKFIGYLLGGATVVAAADLGLFGRGATADAGELPTLPQPAEIADLSDL
LTLAAAPTSQLITVTINDDGTASFELPRTEVGQGITTAAAMLIAEELDLPVDKVHVTLAP
ARPELLFNQITGGSNTIHAMYTPIRVAAAVAKGALLQAAATVLGDSANKLTSHLGHIVAP
DGRRVDYGRLSALAAKEEPEAVEVQLKDEGSHGVVGTPVNRIDALDAVTGTKRFATDLDV
ADALPTMVCRAPTLNGTPNAVNNADEVRNMPGVTHVATIPTGVAVRAATFGQCIDAVRAL
DVSWKDGPVAGMSDEDALAGVRAAEAPVPELPAGETVSGDFTFWFRSNSAMDTNSAVADV
RDGRAEIWASLKNPNVAQGRIAEAVGVPLNNVTVHVVQGGGSFGRRLFDEPAIEAARISH
TMGVPVKLMWHRADDARVGRTHPLATSRIRASYSGDTVLGFQQAHTSVETDFRHGLGDII
TAKAADLPAGLGNLPFAQVIFHLTTILPYDFGAVGQSLVETDTRFNTSSMRNIYSPDVRT
ANELIVDRLAQRMGTDPLEFRLSHLRNGRLRTALETAAEKAEWGKDLPEGVAQGIGVHVE
YKGVTACIMEIDCRPETVNRKVRNAVTGPRVTKATMVIDCGRAINPRGVEAQMQGCVNDG
IAMTLTSSLHLRDGHFQEASWDNYFYTRQWNTPPELDVVVLESTEPPGGVGEAGVAASAA
AAACAYARATGTMPTEFPINHQTLSFEPKPYTPPVPQSPTDGLEHTY
>A4YNW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MWVIREDLQMTGTKFGCGAGLCGACTVHVEGEAVRSCQTMLGDVTNKKITTIEGLSDKGD
HPLQKAWIAEQVPQCGYCQSGQIMQAASLLAKTTSPSKEEITAHMDGNLCRCMTYSRIQK
AISRAAAEMRTASNTTSNERSPT
>M5F3E7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Mesorhizobium sp. STM 4661|TrEMBL
MRLTVDGQSFDINADPEMPLLWALRDLMGKTGPKFGCGIAACGACTVHLDGQPVRSCSLP
VGQVSGAVTTIEGIGIEGKLHPVQQAWLEEQVAQCGYCQAGQIMSAVALLDEVAEPSDAD
IDNAMGGNLCRCGTYPKIRAAIRRAAVLKTAGL
>B9B905|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans CGD1|TrEMBL
MNLDVNRQAMNIDCDPSTPLLWVLRDHLNLTGTKFGCGVAACGACTVHLDGAAVRSCVLP
VAAVAGKRITTIEGLAESPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPTD
ADIDAAITNLCRCGTYPRVRMAIKRAAKALREGRA
>G0L307|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Zobellia galactanivorans (strain DSM 12802 / CCUG 47099 / CIP 106680 / NCIMB 13871 / Dsij)|TrEMBL
MPTYQLTVNGKEHTVEASEDTPLLWVLRDHLNMVGTKFGCGIAQCGACTVHVEGNATRSC
SLPVASAVGMSITTIEGLSEDGSHPVQQAWKEVDVPQCGYCQAGQMMTASAFLAKNPSPT
EEEISEAMNGNICRCSAYNRIKKAVGVAAEKMA
>A0A7W5X0S8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK602|TrEMBL
MNEIDRKLALEGEFPNGAPVNISRRGFLLGAVGTTAGALVLGFGIPVGSARAQQAAAMAP
GTRVPAFLEIRPDNTVRFMSPFVEGGQGVFTAMAQIVGEELDMDPASFIVENAPTGPDYL
VIGGKMRITGGSMSVRMSYETMRRLGALARAMILEAAATRLNVPVGELTTEPGEVIHAAS
GRKLAYGDVATIAMGLPVPAPESVSLKDRSQFRWIGKPVKRLDVLDKSTGRAVYAIDCKV
DGMLHAAVQHAPRLGLSVGNIRNEAEVKAMTGVHSVHRLPGAVAVVAERWWNAKRAVEAL
QVDWAEPGAQPLIPGARNMPADFSTAAFSQRLATEAGEGKDAEKEGDAAGVLASAKTIVS
ATYHSQYVHHAQLEPPSTLARFNDDGTLDLWMPNQAPEMFQAVIAKLAGLDPSKVNIHSP
LLGGFFGRHFLYAAANPFPQAIQLAKDVGRPVKVIWTREEEFLRDPLRPMAAVRFRGALD
DKGMPIALEAITVCEGPTEGISGHNAEKIDDTAVEGLTGKAYAIPNRRIAQIYVENPTML
AYWRSVGNSMNDFLYESFLDELADKGKQDPYELRLRLLEGNERLTNLLKAVADLSGGWKR
GPFTADDGSRRARGVAMASPFGSHTAAIAEVSIRKGEVVVHDVWEAIDPGSIVNPAIIEA
QINSATALGLSQVLMEEAVYKNGEPVARNYDLYPILPPDRMARVHTRIVESGAQMGGIGE
PGLPAIPPAVANAVSTLTGQRIRSMPLSQYTFES
>A0A085GMW9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ewingella americana ATCC 33852|TrEMBL
MEINVNGKMLPLSNVSADTPLLYILRNDLGLNGPKYGCGLGECGACTVLIDGVAARSCSI
PLSGVQGKAITTLEGLGEEGKLHPVQQGFIDEQAAQCGYCANGMIMTLVALFERNPQASE
DQIKNELAYNLCRCGTHLEILRAAEKARQLIAERGQA
>A0A2N7R7H1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. AD21|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGAHRFALAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAANYGMPAFGGMQITGGSTSTW
MEFDRYRLSGATARQMLVEAAAKRFNVAASTIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPVFGATV
KSFEGAEALAVPGVHKVVQVPTGVAVIAEHYWAAKLGRDALNVDWDMGPHTDLSSQGLLD
SFRKLAATPGTSAAQAGDPKGNFDKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAEKCEI
WTGTQFQTLDQMIAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAGMP
VKTVWSREDDIRGGYYRSMFLHQARIGLDGQGMPLSWQHVLVGQSIMTGTLLEATMVKNG
IDPTSVEGVADSPYLKGLAHQQVELHSPQTGINVLWLRSVGHSHTGFVMESLIDEMATAA
GKDPVEYRRTLLKDHPRHLGVLNLAVEKANWTAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTVKDGMVVQSNYHD
YQVLRLNEMPLVEVHIVPSSDKPGGIGEAGVPPTAPAVANAVYALTGQRLRELPLQLSGV
>A0A839VQZ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Herbaspirillum sp. Sphag64|TrEMBL
MTTTRRDFLKTSAIVGGGLTLGIALPGAVSEATAAGTLHTPNAWVHIADNNTITLISARS
EMGQGVYTSMPMLIAEELGVDIHKVKVEIAPVGDVYVNSLLGGQLTGGSTSVREAWEKLR
VAGAQVRTMLISAAAQKWQVDPATLHVHDGSVIGPGGRKATYGALAEAAALLPVPKDVVL
KDPKDFKIIGKPTKRLDTPGKVNGTAGYGIDVKLPGMVYASLEQCPVIGGKVVSFDASKA
KGMPGVIDVVQIRDGVAVVADSYWRAKKAREALTVTWDEGPGAQIDNASMRDSIRNASDT
PIPIKKTGDADAALKGAAKVLQAEYWSPLLAHATMEPQNFTADYRNGKCVVIGPAQFQQG
TAGNVAAALGLKPEDVTVKTTFLGGGFGRRLEVDFAVQAAEISKAVGKPVKLLWSREDDT
SHDFYRPMALHRMAGGLDASGNPVALTFQLTSQSVTQRAFGLPKGTLDPFMAEASVVGYA
IPNMTQSLIEHNSGLRVGYWRSVSHALNAFANESFIDELAAAAGRDPYQYRLGLLSEQPR
LANVLKLAAAKAGWGTPLPAGHHRGVALMEGYDTYMAQVVEISVKESEITVHKVAVAADL
GHMVNPDTVHAQLESSIAFGLSSTLGSEITLEKGRVQQSNFHDYPVIRMFQMPKIDVTLV
QSTEKPGGIGEPATALVGPAVANAFFAATGKRVRRLPLSADNIKSA
>A0A841DX87|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Kribbella solani|TrEMBL
MAEHRRSLDAPSEEAGGRGLLGRRRVLGYLIAAPTLAVGASWLINDADPRSADAAVPSLP
QPEDLFDLGDLQNLAAAPTSGLITVAMRTDGTAHFAVPRTEVGQGITTAFAMIVAEELDL
PIEKVEISLADARPELLMNQLTGGSNSMRSMYTPVRTAAAITRQRLVEVAALQWNVAVDQ
VTATAGVLTGPNGLKATYGALATAAAVTKTVKVAAHLKAKADFKVLGKPHNRVDAHDIVT
GRKQFAMDLHVKGAKPTMVARPPTINGTLRRINNLKALRALPGVTDVVGIAHGVAIRADT
FGQCIDAIQKVDATWGPGTVDDESDASVLKQLRAAQLPMAVPPLLAQTIDAEFVFAFASN
SALEPDCAIADVRPDSAEIWSCLKVPIVAQEDIAKQLGMPIDAVKVHVVQGGGSFGRHLF
HDVAAEAAEISQKMGKPVKLSWSRTDNFRQGRTHPMCTSRVRVNYAAGNVISYEQRHTSV
QTDFGHGLGEMLTAFAADLPIAGNLSFAESIFELTQSSPYNFGVTTQLLNEIPLKFNTGS
MRNIYSPNVVCAEELMVDQLAAKLGRDPVQFRRDFLKDQRLLAVLNKAAAVGKWGKAMPK
GTAQGIAVHSEYRAAVATLVEIDCRPETVNRPIEGEAVTGPRVTKAVIVVDPGFCINPRG
LEAQMFGGLQDAIALALTSSLHIKDGIPLEGSWDNYFYTREWNSPLDVQVVIMPNTSDSP
SGAGELAVAPAFAAVACAYARATGTLPTYFPINHGKLGFEPLPVQPSTPQSPTDGLDHKF
>A0A0H2WC33|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia mallei (strain ATCC 23344)|TrEMBL
MSTSFVLNGKNLTLDADPAMPLLWAIREDAGLHGTKFGCGAAQCGACTVHLEGQAVRSCV
LPLAAVAGKRVTTIEGLASRPAKAVQAAWVKLQVPQCGYCQSGQIMSATALLEQNPAPTD
ADIDAAMNDNICRCATYTRIRAAIHEAAATLKA
>F4L140|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)|TrEMBL
MKNSKSSDTTVSRRKFLSAAGGITFAITTYAILPRWAFENPEMEPNPEDKGRQISAWVHI
RPDGRINIYNPAAEMGQGSMTALPVIFAEEMDADWAAVHIEYSPIEPKIYGPGVWGGRMM
TVGSRAVSGYYDSLRQAGAQARYVLMDNVAKKWNVPMAELSTEPSMVVHRASNRKISYGE
IASFATLPEKLPAIPTNQLKDPKNFRLIGNQKIARFDIPAKVNGSAKYAIDVRLPGMVYG
VISRSPVNGAKPNLLNAAEIRKIAGVIEVLTLDHGIGVVADTLEKALKAKAALRIEWSKG
AKAATHSSEQAYAEYTALVNDDSRKGRSLESKGDPANALKTATKVYTATYKNDYLYHAQM
EPLNAVVSLAADGNSAEVWCGTQAPDGAKGAAARVLGLEESKVTLYPHYLGGGFGRRSSA
DYIEEAAALAKAVRKPLKLIWTREDDMQYGQFRPICLQHLQAGVDQAGNITSWKYIISGT
GDNLLASGAEMPFYTLPDLSIELRAVDHGIRTKHWRAVGHGPNKYAIEAFIDEIAHDQKK
DPYQYRRHLMRNHPRALKVLDTVAEMARWGKKLPAGRAMGIAFAERSGSPGAGICEISLD
RETGKIKVHHIWAVVDGGVIVQPDNARAQTEGSLLMGLSSVFHESITIKNGEVQQSNFHD
YPILRMADIPETLEVKFIDSQEAPSGLGEAGLPFIGPAVANAFLALTGQALRHMPFTPER
VLATVGAK
>A0A087PR09|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Acetobacter malorum|TrEMBL
MRFDLKINSVLREVDVPPDMPVLWVLRDILGLTGTKYGCGVAQCGACTVHLDGQPVRACL
LTVAAAAGHDILTIEAVEHTETGAKVQQAWLDEEVIQCGYCQSGQIMAATALLQQTPQPT
DADIDEAMAGNICRCGTYVRIRKAIHKAASHDA
>A0A5E7HXU8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLTLNINGQDQELDVPADMPLLWVLRDVAHLTGTKFGCGIAQCGACTVHVDGAPLRSCIT
PATAVAHGQKILTIEGLSADGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAELG
>A0A5E7HVJ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVSTIDNLHADPIGKVVQQAWLDTAVAQCGFCQGGQIMSATALLKTHPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A484TJ91|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|plant metagenome|TrEMBL
MEPAAPLLFVLRNDLALNGPKYGCGLGECGACTVLVDGVAARACVMPVRGVIGREVTTLE
GLGDAGCPGPTQQAFIECQAAQCGYCLNGMIMMIEALLRRQPAPDDARIRQELRHNLCRC
GTHVEILQAARRAVALHAQARETACAKRSGQ
>A0A1S8D3C9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseomonas mucosa|TrEMBL
MLSPAATVTLRVNGRETTVEARPCTPLLHVLRNDLALNGPKFGCGLGECGACAVLIDGRV
ARSCTVPLHRAVGRDITTLEGLGSLAAPHPVQAAFIEQQAAQCGYCLNGMIMATVALLSR
NPDPDDAAIRHALRHHLCRCGTHVEILNAVRAAARRLRPATGPENVGSPP
>A0A1C3K2L2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Orrella dioscoreae|TrEMBL
MNLPQPKALHDDLLDRGGALLVIRVPVAPPTPAPGQPGAASDYVPATPEIFVAVLDAPGT
PAGWRALAFNGHVDLGTGIRTALAQIVAEELDVPFEQLEMILGHTEAAPNQGPTIASASI
QISAVPLRRAAAQARAHLLALAAARWQVPATALRARAGRIVFADEADTRTLHYGELLRAR
HDRLTLSDDAPLKPASDYTVVGRARPRVDIPAKATGVLTFVHDVRVPGMRHGRVVRPPYP
GRDGGDFVGHSLLSVDTDSVAHLPGRVRVVVRGDFVGVVADREEQAVAAMRALKVHWREI
PPAPDLGDLEAALRANRAEPRHLRDDGNTAHALATTPDTRRLRRSYVWPYQMHASIGPSC
AVADHANGRLTVWSGTQNPHMLRVDLDRLLDLGEGNIEVVRMEASGCYGRNCADDVCGDA
ALLAIADGAPVRVQLTREQEHQWEPKGTAQLIDAEAALDEDGKLLAYDFGVRYPSNDAPL
LALLLTGRVPGQPRTLQMGDRTAVPAYRYPHLNITCHDMPPLVRASWLRGVSALPNAYAH
ECMIDELAHMAGQDPVAFRLRHLDDTRAIDLLRATAERAHWQAGSAGSRGAPGSDGLLHG
RGVAYARYVHSKFPGFGAAWAAWVVDLRVDPASGHVTIDRVVVGHDAGLMVNPDGVRHQV
HGNIVQTLSRALLEQVRFDAQGVASREWGAYPILDFTRLPEIDVLLMPRQDEPPMGAGES
ASLPGAPAIANALFDATGLRLCAPPYTPETVRNALLARKQPGMPRADAPLSDTQPA
>A0A0S4UUV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum|TrEMBL
MRIRNLEALAGGGVHDPAAPACADAGVATLDRRSFLKLTALAGGGFALGVAPMLAGAQDA
AAKPPSPPQAFLVIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAG
DPYKDPLFGIQLTGGSTALNHSFAQYRELGARARAMLIAAAAERWKVDPSACRTANGVVI
AGSRRATYGELAQAAMALPVPRQVALKNPSQFRIVGKPTLRLDARAKLDASLKFGIDTRL
PDMKVAVVARPPRFGGKVAKYDAAAAKAVKGVVDVVPIQTDRGGTGVAVIADGYWPAKQG
RDALQATWDDAGSRVSSAALMREYKTLADQPGTVAKAADVGAIQSAAKRIRADYEFPYLA
HAPMEPLNCTIDLQSAGGKVSGAKVWVGTQFQTVDQGALAKALGIAPEKVELNTMMAGGG
FGRRAVPTSDYLVEAANVAKAYAAAGHSGPVKVIWSREDDIRGGYYRPMHLHRVDIGLDG
GGKVLGWNHVIVGQSITKGTPFESYMLKNGVDATMTEGVIENDYGFPMQVSVHHPDVDVP
VLWWRSVGHTHTAFVMETLVDEVAHAAGQDPVAYRLARFTDKEHERHRQALRLAVDQSGY
GKRKLPKGQAWGVAVHASFESVVAYVVDVSIDQGKPRVHRVTAGVHANRVINPMGAQAQI
QGGCVFGLAMIAPGFAIEIENGAARNSNFPDFPPVRMPDAPPVDVFFVPSDDNPTGLGEP
GVPPIAPAVANAVFALTGKRLRKLPFDTV
>A0A143GH75|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas yamanorum|TrEMBL
MISQHITVTLEVNGHTTEVSAMADTPLLLILRNDLQLNGPKYGCGLGECGACTVIIDGVA
ARSCVFPLSGAVGRDIVTLEGLGTRETPHPVQQAFIDEQAAQCGYCLNGMIMTAKALLDR
NPNPSEAEVRTELSGNLCRCGTHIEILRAVLRAARQTP
>A0A7W5QM49|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. BK345|TrEMBL
MTRLTVNNEAIEYRLPAETPLLWALRDASNLTGTKYGCGTGSCGACTVDVDGRAVRSCQM
TLAAAEGTFVTTIEGLSRDRTHPIQLALLAENVSQCGFCIPGIVMAAAVLLRRDPMPSEE
AIAAAITNVCRCGIYPRLTAAIQRAGRAIRGEERLPTGARPGIEPAGAARQVPALDPRQR
>A0A4P0V956|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas aeruginosa|TrEMBL
MSPPDTPLLYVLRNDLQLNGPKFGCGLGECGACTVLMDGVATRSCITPVEAAVGRRVVTL
EGLGDATHPHPLQQAFIDEQAAQCGYCINGMLMTAKALLDRNPDPSDGEIRQELAYNLCR
CGTHVEILKAVRRAAERLKNRQEEHPA
>Q1MGD5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium leguminosarum bv. viciae (strain 3841)|TrEMBL
MLPNMDYSELPRALQHMLERGRSTPVQALPRRSFLKLTGTLGLAVGIFPHLAAAQPTDAG
EAPIALKPTEQPSAFVQIAPNGEVMVTINRLEFGQGVQTALPMILAEELDADWNLVRSQL
GTNDMAYVDPLFGMHLTGGSSTIKNSFTQYRELGARVRAMLLAAAADRWNVDVSALRTEA
GVVLAPDGRKLGYGELSEAAMALPVPQKIALKDPKDFRIIGQPTQRLDAQAKSSGQQSFG
IDFKLPGQLTAVVARPPVFGAKIASLDDSAARSVKGVKAVLRVLLDRGAEGVAVVADGYW
QASQGRNALKVEWDTSAVEKVDSEKQLAQFREIANRPGPRQFDADMAPLETAPLSLEAEF
VFPYLAHAAMEPLNCTVRLSDDRAEIWMGSQSAGLDAGVAANVLGLKPEQVVVNVQTSGG
GFGRRFSSSSDTAMEACQIAKAARSAGLNAPVRTLWSREDDMRGGYYRPTHLHRARIGFD
KEGNVLAWDHTIVGQSILTGTVFEKFQVKDGIDAATTEGMRSPYPLPMRLTVHHPVANVP
VLWWRSVGSTHTAFVMETLLDDIARATDQDPVAYRMKMFGNEHPRHRDALQLAVDKSGYG
SRTLAEGRAWGVAVHESFSSVVAYVVEASVVDGQPKLHRVTAGVHCNLAVNPRTVEAQVQ
GAAIMGLSTCLAGAEITLKDGIVEQGNFSEFTVARITDVPEFDVNIVPSADAPTGMGEPG
LPPLAPAFANAISRLTGKPVRQMPFNLT
>A0A7Y9JRC4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides marinisabuli|TrEMBL
MTAPEDSTGPAGTSHDSAPDTGPPGGVRRRSFLGYVVAGTTLVAAADLTMARPARAAVPS
LPQVPELYDLEDLQTDAALPTSQLITIEINEDGTASFALPRMEVGQGITTSTAMIIAEEL
DLPVEKVTVTLAPARPELVFNQLTGGSNSTVSTYTPIRVASAIARGALLDAAARQLGYAV
ERLRTKDGVVIGPGGETLGYGELATLAASPVTEVVDVLLKDPEEFTRIGKPRNRDDARLA
VTGRKDFTLDLEVKGAKPTMLCRPPTLNGSPKRLRNKKKILKMPGVKQVAVVDTGVAVRA
TTFGQCIDAIRAMDVVWNDGPVEGESDQTILARLKKAELPLAVPEVPLLAKTVEERFEFM
FRSSAALEPNCAIADVREDSAEIWAGLKVPILAQQNIAQALGMSQDQVKVNVVTGGGSFG
HKLFSDAAIEAAKVSQAMGKPVKLMWHRADEPRQGRLHPMVTSRIRATVLAGQVLSFEQR
NTSVVTDFSHGLGEIITSTIDEAPTEVGKKVGGLGFSQTIFTLTQELGYNFGVVTQLLNE
TDDRFNTGSMRNIYSPDTRVAVELVVDRLAAEVGMDPLEFRLKHAKSAKVRKALEKVAEE
GDWGRRMPAGFAQGIAIHQEYKGATACLVEIDTRPETVNRRIRNAVTGPRVTRATFAVDA
GLVINPQGLKAQMMGGFSDGLALTLTSSVHLRDGHFLEASWDNYYYTRQWNIPPRFECFV
LPSEDRLPGGAGEAGVAASAASVACAYARATGTMPTRFPINHGKVTFKPKSFVPSVPKSP
TNGLKFTY
>A0A0D1EHY8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Jannaschia aquimarina|TrEMBL
MKFNVNGTEHDIEVEPDMPLLWVVRDILGLTGTKYGCGIAMCGACTVHLDGLAVRSCQVR
ASEVEGAEITTIEGLGTPDDPHPVQAAWIEEQVAQCGYCQSGQIMQAASLLAGNPEPTDA
DIDAAMSGNLCRCASYPRIRAAIRRAQTETGT
>A0A2S6RKD9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Alphaproteobacteria bacterium MarineAlpha9_Bin1|TrEMBL
MIKLNVNGEARSFDGDPKMPLLWYVRDILQLTGTKYGCGAAQCGCCTVLVGGEAVFGCQT
PVSDAEGKDVTTIEGLDPDGNHPVQRAWRAHNVPQCGYCQSGNILLATSLLSNNPNPTDN
EIKDGMSRNLCRCGTYQKMFAAVKTAAKEV
>G0EVK4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MPDNQISVNGKSVEIRSDGCTPLLWVLRCELKLTGTKFGCGVGVCGACAVHVNGKMLLSC
QHHASEMEGKKIVTIEGLDGPEASALRAAWLKHEVVQCGYCQSAQLMAASALLKRTRNPK
ETEIADQMSCVICRCGTYPRIRRAIAEAVGMLRG
>A0A7W5D9C5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Variovorax sp. Sphag1AA|TrEMBL
MAFEIFKCPANDVGPASASRRALLQTGGAVAAGLAIGVNLLQEFAAAASASSFAPNAFVQ
IESDDRITLTMAKIEMGQGTYTSIAMLIAEELEVNPERIVLRHAPADVKAYGAPFGDQFT
GGSTSIRTLHEPMRQAGAAARILLVNAAAQTWNVAASTCRAERGEVIHGPSGRRLRYGAL
AARASRLPMPKDIPLKPASEFKVIGKAVKRLDAKGKTDGTALFGIDAVVPGMKFASIVVS
PVIGGRVKSVNDGKAKALPGVVDVVKIDDAVAVIAENTWYAQRGTQALEIVWDEGPNAHL
STDDLHQLMSLALGRPGVVARNDGDALKVIAADPARVSSNYSNPMLAHATMEPANCTVHV
RADGADIWVGTQVPARARDRAAQLLGLPPEKVTLHNFLLGGGFGRRLYHDYVDQAVLIAR
QVNYPVKVVWPREQDIQREPHRGHYAHTITASLNAEGLPVAISHKTSGPSNLGVFAPAWI
KPDGVDIDAADGAVTFPYDVPNVRTEFVREDGPIPSGFWRGVGPTRNLLAIESFMDELAH
RAGKDPLAYRLALLSRDERSRHVLQRTAEISRWGEPLAPRRGKGIALLYAWDTVLAQAVD
LSVESDGTIKVNKVSCVVDCGTVVNPDTVVAQIQGGINFGLTAALYGEIVVKDGRVQQSN
FHDYRMLRMSEAPQIDVEVVRSAEKPGGIGEPGTAGLGPAFVNAIFAATGKRVYALPVKP
ASLAA
>A0A2Z2NTU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Granulosicoccus antarcticus IMCC3135|TrEMBL
MIHLKLNGQDISIDADPATPLLWAIRDEVGLTGTKFGCGIGMCGACTVHVGGRATRSCIT
PLSAVEGTEVTTIEGLHSENQHPIQIAWNDLRVPQCGYCQSGQIMQAAALLKDIPDPSDD
DIDAVMTGNLCRCMTYPRIRSAVRQAAAATQESISE
>A0A7W5ZU84|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium hassiacum|TrEMBL
MARLTVNNQPVQYRLDDDTPLLWALRDAANLTGTKYGCGTGECGACMVIVDGQAMPSCTL
SLGEAEGRSVTTIEGLSADRSHPVQQALVAEQAIQCGFCTPGIVMAAAALLTTNASPTDE
DIGRAITNICRCGVYPRLTRAIQRAARVLRGEETISAAPPPAIVAPGAG
>A0A840L8T0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paucibacter oligotrophus|TrEMBL
MIKLTVNGRAVALDADANEPLLWALREDLQLTGTKFGCGMALCGACTVHLDGQPVRACAT
PLSAAAGKRITTIEGVASSKTGRAVQAAWVKIDVPQCGYCQSGQIMSACALLASKKSPND
ADIDAAMSGNLCRCGTYNQIREAIHVAADTLKSGKAVKTVGA
>A0A7W8P7K2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. HC6.4b|TrEMBL
MLTRRTFLLGGASALGGLLVGWAVVPPRQRLMTSTPLPTQGTQVGLNGWVKIDADNRVTI
MVPKAEMGQGIHTGLAMLLAEELDADWPQVKVEEAPIDRIYNAVQSIVDDLPFRPDDDSY
IRRGTVWITSKAVREIGTMMTGGSSSMNDLWTPMREAGASARVMLIEAAAERWDVPVREC
RAEKGYVLHPWGHKATFGELSSLAARQPLPRSVVLKQPADFRLIGQPVRRIEAASKIDGA
ARFGIDVLPDGLVYASVVMCPTLGGTVAHFDATPAQKIRGFIKAFAVPPYAGGTGGVAVI
ADNAFRAMSAVEAINVTWHDGAAAKVSSAAVDRRLVEALDHTDGHVYYHVGNVDNAMSRA
ARTIEAVYHAPYLAHGAVEPLNCTVQVADGAATVWVSTQMPRLARHHAAKVLGLDVDLVD
VQTQLLGGAFGRRLELDFVAQAAAIAREAEGRPVQTIWSRAQDFTHDFYRPACAAWLQAG
FDEHGTLVAWHAKSAGQAIVPDALARYYGVPHIPIDKTTCEGAFDQPYEWPAARVSHKIV
ELPVPIGFWRSVGHSHQAFFTESFTDEAAAAAGQDPIAFRTMLLAQHPRHLAVLKRVEKL
SDWGRPLKPAADGARCAHGVALHEAFGSVVAQVAEVSIGANRQIRVHRVVCVIDCGLPVN
PNLIRQQMEGGIVFGLSSALQNEITIVNGQVQQKNFVDFPVVRMNGCPAIEVDIMPSQLH
PQGVGEPGVPPIAPAVGNAVFALTGQRLRTLPLRLA
>A0A2R5F1I9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novimethylophilus kurashikiensis|TrEMBL
MMTRLETELPALPETGLARREFLIATAGVGGGLVLGFLLPRVMGPQAKHGAETSTFRTES
RPFVPNAFIRVDPDGLVTLTVHKVEMGQGTFTSIPMLVAEEMDIDLAKVKLEQAPADDKK
YADPILGSQVTGGSTSIRGAWKPLREAGAMARILLLTAASKQWNVPLEECTTSGGMISHG
KSGKTVSYGEVAGAAALLPIPQKVQLKDPQHYRLIGTPAKRLDTPSKVNGQAKFGIDAQV
PNMKIATVAASPILGGKLTSVDDSKARSIKGVVQVVKLEDAVAVVADHMWAAKQGLAALD
IKWDGGRNASLDIKDIVGQLQEASNNQGRAAPGVVARSVGDFRKTFEQSKHRFEATYQVP
FLSQAGLEPMNCTVHVQPDRCDIWVGTQVPTLAQAGAMTLTKLPAEKIFIHNHYIGGGFG
RRLDVDFINQAVAIAKQLPYPVKVVWTREEDMQHGIYRPYYYDKLSAALDDQGKPIAWSH
RVTGSSVMSRWVPQMVENGLDPDAVEGARDPLYARDNLLVEYIRQEPPGIVTGWWRGVGV
THNMFMIESFIDELAHLAKQDPLAYRLSQIDHVPRAKAVLQLAADKAGWGGALPQNQGRG
LSVQFAFGSYVAQVAEVEVGKDDIRVKRVVCAVDCGTVVNPDTVVAQMEGGIIFGISGAL
YDQITVKQGRVEQSNFDNYRVLRMNEAPVIEVHLIRNNEAPGGVGEPGTAAVAPAIANAV
FAATGKRIRTLPLVPSLMQT
>A0A0A1FAM0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Collimonas arenae|TrEMBL
MTTTRRDFLKTSAIASGGLTLGIMLPGLLDEAQAAGTIYTPNAWVHIADNSSITLISARS
EMGQGVYTALPMLIAEELGVDVRKVKVAIAPPNAVYTNSLLGAQITGGSTSVRDGWEKLR
IGGAQVRTMLISAAASKWHVDAASLRAENGMVLGPNGKKASFGALAEAASKLPVPTDVQL
KDPKDFKIVGKATKRLDTPAKVNGSAVYGIDVKLPGMVYASLEQCPVIGGKVRSFDGAKA
RAMPGVIDVVQIDDGVAVVANTYWRAKKARELLTVEWDEGPVAKLDNAVMMAGIRAAEKD
AKVISIKKTGDAAKAMQGAAKTISAEYQSQLLAHATMEPQNFTADFRNGKCLVIGPTQYQ
QGAQGAVAKALGLKPEDVDVQTTFLGGGFGRRLDVDFIVQAAQISKAVGKPVKLLWTRED
DTTHDFYRPMALHRMKGGFDADGKPVALTFQLTSQSVTQRAFGLPKDTLDPFMAEAAVVG
YGIPNMAQDLIIHDAGLRVGYWRSVSHALNAFANESFIDEMAAAAGKDPYAFRLSLLDQQ
PRFANVLKQAAQNAGWGTPLPAGRFRGIALMEGYDTYMAQVVEISMHDDHEIKVHRVVVV
ADLGHMVNPDTVEAQLQSSIAFGLSAALGGQITLEKGRVQQTNFGDYPVVRMVDMPKVDV
TLVASTEKPGGIGEPATALIGPAVANAVFAATGKRVRKMPLSPDNIKAA
>A0A6J5ETT7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia humisilvae|TrEMBL
MTTDINVVRRPARRTFLKSAGTVAAVALTIGFEWGGLTRRAIGAEPSGTASAAGTFAPNA
FLRVSPDNSVTVIAKHVEMGQGAYNGIATIVAEELDTDWSQVRVESAPADAKRYANLAFG
TIQGTGGSSAMANSWMQLRDAGAKARAMLVTAAAHQWQVPAATLRTERGVVYHDASGKQA
TYGSLVSAAAALPVPDQVTLKDPRNFRLIGQPLPRVDVPAKTDGTAQFTIDVTFPGMLVA
VIQRPPRFGATVHSFDPTAAKAVPGVVDVVQVPRGVAVVGKSFWAAKQGRDALKVEWDDS
QAEKRSSADIMAEYRRMADKPGASARADGDANKAIQGAARKISASYEFPYLAHAPMEPLD
AVVKLTANQCEIWAGDQFQTIDQANAAKAAGLQPQQVSIHTLYAGGSFGRRANPGSDYIA
EAVSVAKALGATGTPVKLQWTREDDIHGGLYRPMYFHKLEAGLTRDGHLVGWRHQIVGQS
IVSDTPFAGMVKNGIDPTSVEGAANIAYAIPNVSVELTTTHTGVPVLWWRVVGSSHTAFA
VEAFIDEAAHAAGKDPYAFRRDLLANQPRMRAVLDLAAQQAGWNDKPLPKGKGRGIAVAE
AFKTFVAQVAEVSIDKDGKVTVDRVVCAVDCGTPINPDVIAAQIEGGIGFGLGAMLYGAI
TLKDGQVEQNNFDGYQVLRMNAMPKVEVHIVRSTVAPTGIGEPGVAPVGPAVANAIYAAT
GKRVYALPLTTQGLA
>A0A841LEP0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Polymorphobacter multimanifer|TrEMBL
MTRFTINNSPVEFKLSPDTPLLWALRDAANLTGTKYGCGAGLCGACTVHVDGIATRSCQV
TIGALEGTFVTTIEGLSDDRSHPIQQAWIAEQVPQCGFCQSGMIMAAAALIKAKPEPTPA
DIDAEITNLCRCGTYPRIRRAIIRAARGDLPTPLPGPDTAPGEAVRLAPSLRPRQPPTG
>G2SEP0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodothermus marinus (strain SG0.5JP17-172)|TrEMBL
MARFELLVNGTRHTVDVPPDMPLLWVLRDVLGLTGTKFGCGKALCGACTVHLSGTPVRSC
VLPVSAVVGQPITTIEGLDPEGKHPLQRAWRELNVPQCGYCQAGQLMTAAALLRQNPTPT
DEDIIAAMGGNLCRCGTYHRIRQAIHRAAELMRQEGTQ
>U2XRF0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Micropelagos thuwalensis|TrEMBL
MSLSDATLDYIETIKGFMDPDEGSALHDMALEVISDFPNSLTVEIGSYCGKSTVYIGNAV
RQRGGLMVSVDHHYGSEENQPGEAYFDPDLADIETGGMSSLAAFRRTIRGADLEDVVIPV
IAPSRMASHIVHGDICFLFIDGGHSMPAALDDYRLWATRVKTGGILAIHDVFPNPEDGGR
SPYEIYLLAIASGLFEEVKAVKSLRFLRRL
>Q8XY74|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ralstonia solanacearum (strain GMI1000)|TrEMBL
MTADATAPRRGRRRFLLGALGIGGALVVGWGVLPPRSRLGDAADFPAQPGEVALNGWIKI
TPQGDVVLAMPRVEMGQGIHTALSMLAAEELDIPLARVRVESAPIERIYGNVVSVVDSAL
PLHPDDAGKAWARALHWIMAKSAREIGLVITGGSSSVADAWQPVREAAATARATLVEAAA
RAWNVQAAQVSVHDGRLIGPGGRQAGFGEVAAHARDIAPPASVTLKPASQYRLVGQPVPR
SDVAGKTDGSARFAIDVRPPGLLYAAVAMCPVFGGRLKAFDAKAAQGMPGVRYVVPFDGA
AGGAPGVAVVADHYWQARQAVAKLDPVWDSGPHAALDSAGIRRQIAAALDSDRGGFTYRS
TGDGLQAFDHVGGATVVEAEYSVPYLAHAAMEPINCTAQVTRDHVQLWAPTQVATLAQLV
AARAAGVRSEQVRIEVPLIGGGFGRRLESDFVGQAVAIAVRTEGRPVQVIWTREDDIRHD
FYRPQAIARLKARIERGRVTALASRSAGQSILAGELGRLFGAPSLGIDRYTAEGLFDLPY
EIAHEHIAHLAVDLPVPVGFWRSVGHSYTAFFLEGFLNEVAAAAGLDPLAMRRDLLEAHP
RERTVLDTAARAAGWGQPLAQAADGAPRARGLALHGCFGSVVAQVAEVSLKDGKPRVHRV
VCAVDCGTVVNPGIVARQVESAVIFGLGAALHGQIQVKDGQVVQSNYSDYPVLGMADTPV
IETHLVPSAAEPGGVGEIAVPPIAPAVAHAVAQLTGKPVRQLPMA
>A0A1R3UJU7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardiopsis sp. JB363|TrEMBL
MPEHTFRLNGEQVTVDVADDVRLLWVLRDLLGVTGPKYGCGISVCQACTSHFNGKAITPC
TVPVSALEESDEITTIEGLPDTVGQELHPMQEAWLEQDVSQCGYCQPGQIMTAVDLVRRA
SDEGRQITDEDLDGIRNICRCGTYPRIRDAIRNGAERM
>Q16DG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseobacter denitrificans (strain ATCC 33942 / OCh 114)|TrEMBL
MHAIKPAHSKSNADATGPSRRAFLAGATGLVVAMALPIKGRAQAVATAQAAFAPNAFIRV
SPDNIVTVLIKHVEMGQGANTGLAILAAEEMDADWSQIRAEQAPDDPSLYANLAFGVQGT
GGSTGLSNSYMTMREAGATARALLIEAAAQTWGIPAGDVSVSAGVVSNDATGQTATFGEL
AERAATLPMPQDVTLKDPSEFKLIGAEGITRLDAADKARGKSTFSIDVMRDGMQVVTVLH
PPKFGAVLASFDATAALDVPGVTAVHQIASGVAVYGADTFAALRGRDALVVQWDETNAET
RSSQEIEEEFLKAARSPARVAENIGDVDAAFDQAERSFEAEYIFPYLAHAAMEPLDGVVE
WTPDRVDVWSAIQIPTIAAPVFSSTLGVAPEAVSLHTMYAGGSFGHRATATNHFENEMAQ
VAAAAGPGSYKLQWTREDDMTQGYYRPLTVHRFRGGLDADGNITGWDNTVANQSIMAGTM
FEQALMGDGLDRTSYEGSTDLPYALPARRVSWAQMQTGVPVLWWRAVGHTHTAYATETFL
DELLIAGGRDPVQGRLDLITQDRPRDRAVLERVAEMAQWSGPGTGERRYGVALHRSFGSF
VAQIAEVENRDGTPHVTRVWCALDCGVAVTPDVVRAQMEGGIGFGLSAALFEQLTLEAGG
TVRERNFDAYRVLGLEEMPEIMVDIMPSEVAPTGVGEPGTPPIAAAVGNAWRAHTGQTPR
RLPIIGA
>H0TPA9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. STM 3843|TrEMBL
MIAAFTLDRRQVLLGGGALIVGFSLRGAAAQEAASPAKRPGSLATTPYLDSWIRIDADGR
ITVFTGKAELGQGIKTALQQIAAEELDVSFEAVELVTADTKRTANEGYTSGSHSMQDSGT
AIRHAAAQARELLIAQAAQRLNQPADSLRAENGAVIAPDGTRLGYGELIAADILHVEAQP
SSKLKDPASFKVMGRPIPRVDIPAKVTGGAAYVQDMRLPGMLHARIVRPPSYGATLTDVD
GAAIEKMPGVVKVVRNGNFLAVVAEKEFQAIKAMLALAAAAKWQEHPQLPAERGVRELLT
NLPSRDMTILNVSDPSVSGLRSIEATYTRPYQAHGSIGPSCAVAQLVDGAMTVWSHTQGV
YPDRQAIAEMLQLASDSVRVIHVEGSGCYGHNGADDAAADAALIASLIPGRPIRVQWMRE
QEHAWEPFGPAMLTQAKASLDAEGRIADWHFEVWSNTHSMRPGGAGCLLAAQHKAEPVAE
PAPKPLPLPEGGGDRNAIPIYAFPNAKVVHHFISQMPLRISAMRSLGAYHNVFSIESFMD
ELAALAGKDPVEFRLAHLKDQRARDVVQKAAEAFGWAQDQKPPAGRGYGFAFARYKNLAA
YCAIASEIEVISDTGRARLVRAVAAVDAGQIVNPNGLINQIEGAIVQSSSWTLYESVTFD
DTRITSIDWQTYPILRFSAVPDTIDVHLIDRPGEPFLGSGETAQGPAAASIANAVTNAIG
KRLRDLPLTRQRIRAAIEA
>A0A7Y9HSW1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MRIEWLNQDSIAGAPAGAAASGMSRRGFMKAGAVAGGGLVLGFFMPGAGRWANAQQAPAK
VYEPNAFLHIAPDNTVTVQVNRLEFGQGVQTSLPMLIAEELDADWSQVRGALAPAGDQYK
DPLFGIQITGGSGSIAHSYTQYREIGAKARQMLIAAAAEQWKVPAAQIKTVKGTLIGPAG
QKATYGAMADAAMKQPVPATVQLKDPKDFTLIGKPVRRLDARAKSTGKQTFGMDFKAPDS
KVAVVARPPVFGAKVARFDASKAKAIKGVIDVLEVKTDRGGSGVVVIADGYWPAKTAREA
LAIEWDTSGVDKVSSAKQVEEYKALSQKAGTPVRTADTSKIAGAAKKISAVYEFPYLAHA
PMEPLNCVVDLRKDGCTVWAGSQFQTVDQGAIAATAGLKPEQVVLNTMMAGGGFGRRAVP
TSDYLVEAVNIAKVWQAAGHKEPIKVIWSREDDIKGGYYRPSHVHRADIGLDAKGEIVGW
DHVIVGQSITSGTPFESMMVKNGVDATMIEGMGEPYEVPLNLSAHTVKANVPVLWWRSVG
STHTAFVMETLIDEAAHAAKMDPVAYRKKIMGEKGKRHVAALDLAVAKSGYGKKALPKGQ
AWGVAVHESFNTVIAYVVVASVKNGTPKLHKVTAGVHCNTAVNPMTIEAQIQGAALMGLG
MTLPGAAITLKDGVVEQQNFSDYTVARMTDMPAIDVHIVPSNDPPTGMGEPGLPPLAPAF
ANALFKLTGKRLRKLPFDLQSA
>A0A7Y9HSS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Duganella sp. 1224|TrEMBL
MNARRGFLKIAGGLVVAFHIPFEALAAEQKPIAKGASDAAPEVNAWVVVKPDDSIVIRIA
RSEMGQGTLTGLAQLVAEELDADWSKVTTEYPSPGQNLARKRVWGSFSTGGSRGVRESHD
YVRKGGAIARTMLVQAAADTWQVPASECVAAASVITHKPSGRTTSYGKVAGAAARLTPPA
DVALKDPKDWKLAGKRLARLDTVDKTTGAQIYGMDLKLPGMLNAAIKDCPVFGGTVKSFD
ASAAEKRPGVKKIFKLGDTAIVVVADTWWRAKSALDAVTIEWDKGPNARLSSKDVAATLK
AALDAPEAVVGNANGDARAAIAASKRKVEAVYSFPWLNHATMETMNATAIWTPERCEVWT
PTQNGEAALAATAEAAGLPATKCDVYKMHLGGGFGRRGATHDWVTQTVKIAKEFPGTPVK
LIWSREEDMLHGRYHPVTQCKLTAGLDDKGNVTALHMRIAGQSILASLGSTLKDGKDPVV
FQGLNAPGPEASIGYSFPHLLVDHAMRNPPVPAGFWRGVNLNQNTIYLECFMDELAHATK
QDPLAFRRKLMADHPKHLAVLNAVAEKAGWGNPAPKGVYRGLAQTMGFGSYVAACAEVSV
DRKTGKVKIHRIVAATDPGYAVNPQQIEAQVEGSFVYGLSAALYGECTLKDGQMEQSNFD
TYQVMKLEEMPKVESIIMPSGGFWGGVGEPTIAVAAPAVLNAIFAATGQRVRDLPLKNHS
LVKKA
>A0A1Y1J038|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Comamonas testosteroni|TrEMBL
MPTGAFAKERRPSEDGASVIAATLEEDIVLGLLAPRVRLVEDELMERFAAKRHVVRDALA
QLESAGLLERRRNIGSMVKAFSREEVVHLYEMRELLELEAMRRIVLPLDRDALEQLRRIQ
AGHDAAIQQQDPRGIFRTNQEFHRLLFAQCGNVFLSQSIEDFARQTHAIRFGTLMSRERQ
LQSQQEHHELLAVLAQGEGSRERLIRLTAEHLVPPRDHYLKTQEALLP
>Q1IBG8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas entomophila (strain L48)|TrEMBL
MELRINQQTYQVEADADTPLLWVIRDDLGLTGTKYGCGLAQCGACSVLVDGNVVRACVTP
VAGVVGREITTIEAIEQDAVGKRVVAAWVEHQVAQCGYCQSGQVMAATALLKHTPKPSDA
QIDAAMVNLCRCGTYNAIHAAVHDLAQGENA
>A0A0K8NZS7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MNIASLRSSRRGLLRAAGAGVAVGFLAGCTLPVIPKRPSADAAAARGWIRFADGRYTLFV
PRVEMGQAILTALKQVACEELGIGWDQLDAVLPDTRQIARVRATVGSESVKDFALPLAQA
CATLRDALAAGVRTGELAAAERPVDALRSFSARAERRHVGRPVRLEQGLAIVRGQPLFAA
DVRRPGQVFGRVLRAPASPELRSRATAFDAAAARAVPGFVALVEDELLVHGASQGLGIVA
RTPGALDRIEAALAVQWQVEGSFGQPDIDAAVDIDRRMASGRLARQVHADRIEGTGPWDV
DLRIDVPLAAHAAIEPRAAVAAFAADGRLELWVGTQDVFYQRDVVARRLALDEAKVVVHG
QRVGGGFGGRTLCTVELEAAVLARAVRLPVKVQWTRAQEFRLGFHRPPSSHRIRARLKDG
RIEQWWHGFASSHILFTNAALPPWLQRLTDLVGDDGVARGARLPYRAAARRTAFDLVRLP
VFTGPWRGLGAGPNVFAIESAIDECARAAGVDAVAFRRANAEDPRLVRVLDRAAEAAGWA
AADRRPGQRGRGVACGIYKAMSYAAVVAEVEVEPATGRIRVDRLVCAHDCGQVVNPDQVR
AQCEGNLVWGLGMALVEQLPVAASQVSAAHFGDYPIPRIGEVPPIEVLLVDEGEPPTGAG
ETAIVAAAAAIANAVRAATGVRPQRLPIVLHGREMMPR
>A0A0K8P248|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ideonella sakaiensis (strain NBRC 110686 / TISTR 2288 / 201-F6)|TrEMBL
MLFNPTPTPELPRALQHLLDRETPAEAAVLPRRQFLKLAGAGAFALGAWPLAADAQAPAA
AAAAGLKPFQQPAAFVEIARDGTVTVAINRLDFGQGVQTALPLILAEELDADWSRVRSRH
GSNDMAYADPLFGMHLTGGSTAIKHSFTQYRELGARTRAMLVAAAAQRWQLEPAALRTEA
GTVIGPGGRRLGYGELAEAAMALPVPETVVLKDPKAFRLIGRPTTRLDQRAKSSGRQDFG
IDVRRPGQLTAVIARPPVFGAKLASLDDSGARAVRGVKAVLRVPLDRGAEGVAVIADGYW
PARQGANALKAQWDTAGVERVDSARQLAQYRALLDQPGPRHFDADMAPLAGAPKTLEAEF
QFPYLAHAPMEPLNCTVELRSDGATLWVGSQMPGLDGQAAAGALGLKPEQVRVNVQMAGG
GFGRRAIPSSEYVVEACRVARAAREAGLAAPIRTLWSREDDIRGGYYRPMHLHRARIGFD
ERGRVLAWDHVIVGQSIIGGTFFEGMMVKNGIDATAVEGMRAPYPLPMRLTVHHPKVNVP
VLWWRSVGSTHTAFVMETLVDEIARATNQDPVAYRLALIGSEHPRHRAALQLAVDKSGYG
RRTLPAGRAWGVAVHESFDSVVAYVVEASLADGKPVLHRVTAGVHCNLVVNPRTVETQVQ
GAALMGLATCLPGAAITLKDGVVEQSNFGDYALPRITDMPEIAVHTVPSADPPTGMGEPG
LPPLAPAFANAIARLSGKPQRQLPLAV
>A0A7W8S2W9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sp. CI2|TrEMBL
MIELTINAQKHVVDAPPEMPLLWVIRDIVGLTGTKFGCGIAQCGACTVHLDGEPARSCVT
PVAAVGGRRITTIEAIGATPAGQKVQKAWLDIDVVQCGYCQSGQIMSAAALIASNPAPSD
ADIDAAMAGNICRCGTYVRIRAAIKQAAKGA
>A0A857JPV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraglaciecola mesophila|TrEMBL
MIEFSLNGKKITSDAQGDTPLLWVIRDEFGLKGTKFGCGIAMCGACTVHFNGSPVRSCSL
PISAIANAEIRTIEGLENQHPLQKAWVEHQVPQCGYCQSGQIMQAAGLLATNADPSEEEI
EAYMSGNLCRCMTYARIKEAIQDVAGQSESVVQIYNPKRDAQGVS
>A0A7Z0CFY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sulfitobacter geojensis|TrEMBL
MKLTVNGTEHEVDVEDDMPLLWVLRDELGITGPKYGCGIAQCGACTVHMDGVAVRSCQVA
AADVDGDITTIEGLRTPTALHVVQEAWIEHQVAQCGYCQSGQIMQAASFLDLNPDPSDDQ
IDAAMSANLCRCGTYPRIRAAVKTAANRLQEV
>A0A7Y9W1I6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGNRFAMAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVEHSPASAADYGMPGFGGMQITGGSTSTW
MEFDRYRLAGATARQMLIEAAAKRFNVAPSTILTESGVVIAGDNRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRAKFGMDVQFEGLMTAMVARAPAFGATV
KSFEGAEALAIPGVHKVVQVPTGVAVVAEHYWAAKLGRDALKVDWDLGPNADLSSEKLLA
SFRKLAAMPGTSAAQAGDAKGNFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISADKCEI
WTGTQFQTLDQMVAGKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMP
VKTVWSREDDIRGGYYRSMFLHQAKIGLGADGMPLAWQHVLVGQSIMAGTMLEKTMVKNG
VDQTSVEGVSDSPYIKGLAHHQVDLHSPTTGINVLWLRSVGHSHTAFVMESLIDEMAAAA
GKDPVEYRRTLLKEHARHLGVLNLAVEKANWKAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLGMALHSKLTLKDGHVVQSNYHD
YQVLRLNEMPVVEVHIVPSTDKPGGIGEAGVPPTAPAVANAVFALTGQRLRELPLLLSGV
>A0A5P9CV59|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Labrenzia sp. THAF82|TrEMBL
MLHLLQKPLEAAQPSRRSFLKISAGAVGGLVLAMNLPRAAQAAAGDGELIQPFVHIRPDN
TVVVLSKHLDKGQGTATGLATLVADELDAAREQVSAEFAPSNPQVYANTLFGVQGTGGST
AMANSFMQYRQAGAAAKAMIVAAAAKDWGVPAGEISVANGVVSHASGKSATLGELAGLAA
AEDVPAEPTLKTPDQWVYIGKSFPRVDVKNKTVGAPNTYTMDFQPDGLLVATVARAPRFG
GKVKSFDATEAKKVPGVVNVLQIPNGVAVIATSTWPAIKGRELLEVEWDDSAAETRSSDV
MMAELKEMTTKPGLNVRDDGDIDAALEASARVIEEDFDFPFLAHGAMEPLDVAISFDGES
AELWLGSQIQTIDHNVAATVLGIPFEKVKINTLWAGGSFGRRAQADAHPVVEATTLAQAM
RADGMDAAPVKIVWTREDDMAGGYYRPMSAHKVKVGLDENNNVTAFKYTIAAKSIIKGTP
FEQMLMKDGVDHNMTEGAHDTTYAFPMMNMDQAFQETQVPVLWWRSVGHTHTAYVMETMI
DRLAKEAGKDPVAYRLEMLKDDPRKVAVLKLAAEKAGWDTPPAEGRHRGVAVHKSFGSYV
AEVVEISFRDDDTVKVEKVVAAVDCGTPINPDNIVAQVEGGIGYGLGAILRNQVTLADGV
VEETNFDTYEPIRMSDMPEIEVHIVASNEAPTGIGEPGTPPIGPAVANAIAAAKGNWVTS
LPLAKNGLV
>A0A7Y9W1B3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas moraviensis|TrEMBL
MRARKKNALELSRRRLLLGGSTALTGLVLSSWLPPLVTKSAAAEAAAAGRLGDRSTDGFG
AFVRVGHDGRVTVISPKIEMGQGMQTGIAMMVAEELEVGLEHVTIQEAPPNTALYADTLM
QFQATGGSTSTRYTWEPLRRAGATARILLVQAAALRWHVAPSLCRADNGRVLGPNGQHAS
YSELVEVAATLPLPNDVPLKSPEQFKLLGTPARRLDTPTKVNGKARFTIDLQIPGMLIAS
TVTCPVHGGRLRSVDDRQALRVSGVRDIVRLDNAVAVTASSFWACQQAIKVLRIEWDFGP
HASINSAELDDALIEASKRSGVIARHEGDIDQARQQSTSQFEAVYEQAMLSHSPLEPVSC
VAHVRPDGCDLWVGTQVPVFAMQTAARVTGLPEDKIHVHNQLIGGAFGRRLEFDFVTQAV
AIAQQVDYPIKLIWSREEDMTHDLYRPLYADRLNAALDEQGRPIGWEHRIAGASVLARYV
GSLPPSGVDADAVEVAVEPIYHLPHLKVRYIRQDPGVVPVSWWRGVGPLRSTYALECFID
ELAHNAKADPVAYRLSLMERQPRAQAVLRLLAEKTDWGRPLPAGQGRGIAVSAVFGSYVA
TLVELEMQGDTAFRIKRLVSAVDCGLVINPTSVIAQIEGGTLFGLSASLFNEILIKNGQV
QQTNFHTYRQLRISEAPPVEVHLSSSLETPGGIGEAGTALIGPALVNALFAASGKRIRRL
PLSRMGYYPV
>A0A447IHJ8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paracoccus haematequi|TrEMBL
MSIPTTRRGFLAGGTGLLLAVTLPVGRGRAQMTVAGPFAPNAFVRIGTDDLVTVMIKHLE
MGQGPYTGLATLVAEELDADWSQMRAEGAPADDRLYANLAFGAQGTGGSTAIANSFMQMR
KAGAAARAMLVAAAAEEWGVPASEITVKAGVVAHEASGRSSGFGALSTAAARQPVPEDPP
VKAPADFVLIGTDRPKLDSASKSTGTAQFTMDVYRDGMLTVVVAHPPRFGATLARVDDSA
ALAVKGVEMVRTVPSGVAVYATNTYAAMKGRDALILEWDDSKAETRSSTQMFAAFAEAAA
QGGETVEEEGDLSAIDGAARVLTAEYRFPYLAHAPMEPLDAVIETKGGKAELWFGSQFPS
FDKPTIAGALGIAPEDVTINVLMAGGSFGRRAQGSAHLAAEAGAIAKAAGRDGAFKLVWT
REDDVKGGYYRPMTVHRLRAGLDADGAIVAWENVVANQSIMAGTPMEAMLKGGPDNSSFE
GSTGLPYRLGARRIGWARMESPVSVLWWRSVGHTHTAYAVETFLDEVLEAAGKDPVQGRL
DLLPPEAARERAAIAEAARMADWQGPRRDGKGYGIAYAKSFGTYVAEVVEVEDRGGTPRV
TRVWCAVDCGIAVNPNVIRAQMEGGIGYALSAARHSRITLAPGGTVEQSNFHDYPMLRIA
EMPAVEVSIIRSAADPTGVGEPGVPPLAPAMANAWRALNGARQYQLPFGGAIS
>D3P7P2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum sp. (strain B510)|TrEMBL
MLHHLIRQAAQTGFGGTPSPLPLAVPSRRGFLKAIGAGAGALVVGAHLPFPALAAETAPK
IIGPADPRPHAFIIVAPDNTVTVLAKHLDKGQGIVTGIATIVAEELDADWAQVRGAFAPA
DAKLYANHFFGIQGTGGSTAVANSWDELRMAGAAARAMLVAAASARWSVPAGEVTVSKGV
VRHAAGNRSLTFGELAEEAAKLPVPQQVKLKDPKDYVLIGKPDLHRLDHVSKTNGTAIFA
MDIRRPGQVTAVLARSPRFGGTVKSVDDAAARNVPGVIEVVSLPVGVAVIARNSWAAMQG
REALTITWDDSKAEMRGTDAMLADYRKLAETPGAVAAAKGDADAAFAAAKAKGGHVVEGE
FVFPYLAHAPMEPLNAVVALNPEGGCTIWAGSQFQTVEQMVAAHILGCKPEQVRIETQWA
GGSFGRRATTTADYIAEAVMIAKAYPKAPVHLVWTREDDIKGGYYRPLFLHRIAAAVDAT
GALVAWKQRIVGQSFMAGTAFEAVMVKNGVDATMVEGASDMAYPVPNLAVDAHTVASPVP
TLWWRSVGHTHTAYAKEVMIDRLAKAAGKDPVAFRMEMLKDHPRLAGVLKLAAEKAGWGQ
PLPKGKGRGVAVHESFNTYVAHVADVTVDAKGQIKVDRVVVAVDCGEVVNPDIVKAQMEG
GAGWGIGHALRGEITLTDGKVDQGNFDGYLPLRMSDMPAVEVHIVPSHERPTGAGEPGVP
TVAPAVANAVFSVTGQPLQTLPFSRGGIVS
>A0A7W4T5E5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas umsongensis|TrEMBL
MSQLPNDFALSNLSRRGFLKGVGATSALVLAASWGWQDALAAEKEQKFGADGMPNGWIDD
PKVYISIAADGSVTVICNRSEMGQGVRTSLSMVVADELDADWAQVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARTMLEQAAAEQWKVPVGECHAQLHKIIHKPTGRELGYG
ALAAAASALAVPARDSLRLKQPSEFRYIGKEGTKAIDGADIVNGRAVYGADVHFDGMLFA
TIARPAVYGGKVKSFDASAAMKVPGVIKVLQVESRPLPSEFQPLGGVAVVASNTWAAIKG
RDALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNIDQAMSAADSTLEASYYLP
HLAQSPMEPMVAIARFKDGVCEAWAPSQAPQVTRERIGERLGIPFDNVTFNVTLLGGGFG
RKSKPDFVVEAAILAKEFPGKAVRVQWTREDDIHHSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNVRLENPEAAVHTRVGWYRSVSNI
PHGFAIQCFVDELAHKAGQDPLKYQIKLLGPDRQIDPRTLSEEWNYGESPERYPIDTARM
RTVLETAAKAAGWGRKLPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLIVHKADIAVDC
GPQINPERIRSQFEGACVMGLGNAVWGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLQGWQKAEA
>A0A7W4T551|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas umsongensis|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGAPARSCIT
PIGSVVGQNVSTIDNLHADPVGKVVQQAWLDSAVAQCGYCQGGQIMSATALLKTNPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A0P0M9Q4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Limnohabitans sp. 63ED37-2|TrEMBL
MKRRTWILSALGVTGALVVGWGAMPARSRLGSPELMLPTQGDVALNGWIKIAADGAVVLA
MPRSEMGQGVHTALAMLVAEELDVPLARVRLEQAAADSIYGNVAMLVASLPFHPLDSEGE
KPAKIKLAEWMVGKIARELGINATGGSSSVADLWEPLRMAAATARASLVQAASSAWKVPA
NEITVREGVMQHASGQKAHYGQMGAAAAGSTPANITPKARADWKLIGQSAARNDIPAKVM
GQAQFGMDVRLPGMLFAAVRMNPVLGGAAATMDTQAALALPGVSQVVALDAWGGGTGGLA
VVASNTWQARQGAQAVKVQWPAAAAGASGAVDTTRIQADLLNALNTESGFTFHEQGLPLK
AEQTAASRIDALYQAPYLAHATMEPMNCTAQVKYGKVEVWVPTQVPQMARAMAAKVAGVK
EDQVTVHVTLLGGGFGRRLEVDFVGQAVQVAMACKGAPVQLVWSREEDMTHDFYRPMHLA
KFQASIDAQGEVSSLRIKSAGDAITPRWMARAAPHLSGPIDMPDKTTSEGLFDLPYGFLN
QHMSHVATKSGVPVGFWRSVGHSHNAFFSESFIDELAVATKQDPLAFRLNLLKDAPRYAA
VLQLAAKQAGWGQPLPAGRAQGIALHKSFGSIVAQVAEVSVEQGQIRVHHVVCAIDCGTV
VNPDTVAQQMQSSVVYALSAALFGQIDIVGGVVQQNNFPSYPMVTLSQAPLVETHIVPST
RHPAGVGEPAVPPLAPALGNALFALTGKRLRALPLKV
>A0A7Y9RZV8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Nocardioides daedukensis|TrEMBL
MTKQEATNSDVAPSTAGLDASGPLHFGRRRFLGYVLGGATLMAAADLGLMPERAAAAVPT
LPSIPELYDLNDLLTHAAAPTANLITININEDGTASFALPRAEVGQGITTSTAMIIAEEL
DLPLEKVIVTLAPARPELLFNQLTGGSNTTISTYTPIRVAAAIARKQLLEAAAILLGDTV
GNLVAKAGVIEAPDGSSVSYGELATKAASPTTEQVEVELKEDKGFSIVGTPRNRVDALAA
VTGKKEFTTDLAIPDALPTMVCRAPTLNGIPLAIENKAEVLALDGVRNVALIDTGVAVRA
DTFGQAIDGVRALKVRWRDGPVAGDSDEDVLKGLRKAELPLPTLPGKGLARTVGGDFTFW
FRSNSAMDTNSAIADVRDGKARIWSGLKSPIVAQQAIARELGLKDSDVEVNVVQSGGSFG
RRLFYDAALEAAKISKAMGAPVKLMWHRADDARAGRAHPMATSRVRAALIGKEVVALQQS
HTSVETDFRHGLGDIISATAADLPAGVGNLGFAETIFTLTQEVPYNFGLVTQTLLETDQR
FNTGSMRNIYSPDVRCANELVVDMLAKDAGLDPYEYRRKMLRLGVVRRVLDKVAEEGEWG
RSLPSGVAQGIAIHKEYKGASACLVEIDTRPQTVNRKVRNAVTGPRVTRVTFAIDVGLPI
NPRGLEAQMQGGINDGIALALTSSLHLRDGHFMEGSWDNYFYTRQWNTPPEVNVIVMPPS
SDQPGGAGEAGVAASFAAVACAYARATGTVPKEFPINHGQIAFEEKPRVPPVPQSPTDGL
SHTY
>I4KK52|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens Q8r1-96|TrEMBL
MSALNINGREYTVDVDPSTPILWTLRDTLGMTGTKFGCGAALCGACTVHLDGQAIRSCVT
PIAAAEGKKITTIEAATNGSDPVGSAVHEAWVKHDVAQCGYCQSGQIMSATAFLKAQPKG
KQPTAAEIDSAMAGNICRCGTYARIRAAVADAAKALA
>A0A7W6MPE9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Aurantimonas endophytica|TrEMBL
MGIQNIKVSRRSFLAGTGLVIGVALATRSLAASALLKGTPADAVGPVQNLNAFVRVATDG
TVTILSKHIEFGQGPYTGLATIVAEELDADWGQMRAAAAPADDEIYKNLAFGLQGTGGST
AIANSWEQMRVAGATARAMLVAAAAEMWDVPAGEITVSKGRVSHAASGRETGFGELADKA
ATMEPPANPALKDPKDFVLIGKDRPKLDTPAKTDGTAIFTLDVLADDMLIAMVAHPEHFG
ATVKSYDDSAARQVAGVVDVKRVPQGIAIYAENTFAALKGRAALTIEWDLAAAESRSSEE
IYDDYRRLIGGELLGATDNGDVEAALSGDGITRLESELVFPFLAHAPMEPLDAVLVRADD
GSIDCYTGSQFPGQDKAAIAETCGVDPAMVRIHTQLAGGSFGRRAQFGSPYMREAAAVFA
ASGMNRPIKHMWTREDDIRGGFYRPIYVHSLKGAIDAEGNIVAWDQVIAGQSIMKKTELD
DTTVEGASDLPYTIPNLRVRAHQTELQVPALWWRSVGHTHTGFAVETFIDELLERGGKDA
VDGRLALLSEHPRHTGVLKRVAELADWGSPVPDGRQRGVAVHKSFNTYVAEIAEVSIGAD
GGPRVHKVWCAVDCGVAVNPNVIRAQMEGGIGYGLGAVLFDQITLGDGGKIMQSNFHDYR
SLRIDEMPEVEVAIIESSEPPTGVGEPGVPPIGPAVANAWRRLTGQPVRRLPIVGGLTS
>G7ZI17|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Azospirillum lipoferum (strain 4B)|TrEMBL
MIRINVNGENRQVDVPEDMPLLWVLRDELNMTGTKFGCGVAQCGACTVHVDGTPTRACQT
PVGMLGPDSKVTTIEGVKGKAAQAVQAAWQKLDVVQCGYCQSGQIMSAVALLTDNQNPTD
QDIDAAMDGNVCRCATYVRIRAAIKDAAQTMRA
>A0A7W9Z669|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodanobacter sp. MP7CTX1|TrEMBL
MLSLSVNGESHSVDVPPDMPLLWVLRDVIGLTGTKFGCGIAQCGACTVHLDGQPVRSCVL
AVGSIGSKAVTTIEAIGDTPSGQKIQQAWLDADVVQCGYCQSGQIMSATALLKRSPNPTD
AEIDAAMSGNICRCATYVRIRAAIKQAATGKPEGMQTIVTAPEGAAS
>A0A221UV46|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Arenibacter algicola|TrEMBL
MADFNLNINGKTQKVEVDPNTPMLWVLRDHMKLVGTKFGCGIAQCGACTIHLGDTAVRSC
QLPVSAVGEQQITTIEGLSENGDHPVQKAWLEVDVPQCGYCQAGQIMTASALLKSNPNPT
DTEIESAMNGNICRCGTYTRIKKAVKMAAANSANL
>F6AUS2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Delftia sp. (strain Cs1-4)|TrEMBL
MTDLTINGKTVSMDLDPETPILWALRDTLEMTGTKFGCGAALCGACTVHMNGQAIRSCVT
PISAAAGQKITTIEAMTSGSDRVGTAVRDAWVRHDVAQCGYCQSGQIMSATAFLKSLPKG
KKPSGEEIDAAMAGNICRCGTYARIRTAVADAARTLG
>A0A1L3LG41|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sinorhizobium americanum CCGM7|TrEMBL
MLPKLMQSITLPAARVEASRRQFLIGALATGTGLAIGFRLLSASPAAASETPAAGAHAFS
PYVMIDGDGKVTVLSSQFEMGQGSYNGIATLVAEELDAEWSTIDVKGAAGNLPAYGNIAF
GGAMQGTGGSTSMVTSWERYRKAGAAARAMLVAAAASDWGVDAAEITVDKGVLSHPSGKS
GGFGTFAAKAATLPVPADVKLKQPSDWKLIGNSELKRFDSARKANGTEQYTIDVKLPDML
TAVMIHPTLFGAKVKSFDASAARAIKGVVDVVETPRGIAVVGEHMWAAIKGREAVTVEWD
EAGAEKRGTQQLMSMYRDLVKKPPAAVARKDGDAEAEFAKAAKVIEASFEFPYLAHAAME
PLNAVARMNEDGTLEIWGGHQFTEVYQKLAGDVAGVAAEKVRLHVMKTGGSFGRRAVFDG
DVVVEAVHVAKAIGFRAPVKLQWTRENDMRAGRYRPAYVHSLKAGIDDSGKLVAWNDHIV
GQSIMAKTAFEGMVKNGIDPTSVEGANNLPYAIPNQTVGLTTTDVGVPVLWWRSVGSTHT
AFAAETFLDEVAEAAGRDPVEFRLSMLEPGSRHATVLKLAAEKAEWEKPLPQGRFRGVAI
AESFGSVVAEIAEVSTDGNGQIKVERVVAAVDCGLAVNPDQVRAQVEGGIGFGLSAILGE
EISLTDGAVDQGNFDLYTPLRIDAMPAVEVHIVASANPPSGIGEPGVPPIGPAVANAAYK
ALGKRLRVMPFSKSLDA
>A0A7X6BEQ9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas trueperi|TrEMBL
MTRFTVNNQPVQYDMDPQTPLLWALRDASNLTGTKYGCGTGDCGACTVDIDGAARLACRE
TIGAIEGTFVTTIEGLSPDRSHPVQQAFLAANLVQCGYCIPGMVMAASVLIRTNRNPSEE
DIRQGIPNICRCGIYPRLVAAIQDAARIARGDPADGA
>A0A375EM06|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MTATQLQPPAQADAATPRALRLMLLQATGVLLVTRAPQAAPRPAPGQPGAASDYVPALPD
LFIAVRDSGEVLAFNGHVDLGTGIRTALAQIVAEELDVPLEHVRMVLGHTEATPNQGPTI
ASASIQISALPLRRAAAQARAWLQARAALQLGVDASALEAENGVLRVRGTQASIRYAALV
AGEHVELPLAEDVPVKPVESYRIVGRAAPRVDIPDKARGALTFVHDVRVPGMLHGRVVRP
PYAGRDSGAFVGNSLLAIDRDSVRDVPGLVEVVVQGDFVGVVAEREEYAVQAARRLRVRW
KPVPPLPALDDPEPALRANPATRRELLSEGELPAGGAGTVLQRRYVWPYQMHGSIGPSCA
VADWHEEGLTVWSGTQNPHMLRIDLSRLCGLGEDHIEIVRMEAAGCYGRNCADDVCADAA
LLSRAVRRPVRVQLSREQEHLWEPKGAAQLMDVSATLGADGALLGYDFTSRYPSNDAPTL
ALVLTGAVSNAPRTLEMGDRTAVPPYAYAARRIGCDDTPAIVRASWLRGVSALPNAFAHE
CVIDELALEAGADPVEFRTRHLPDQRAADLLRAVADAAGWQRGAAGSRGVPDADGRLRGR
GVAYARYIHSRFPGFGAAWAAWVVDLSVDTGTGRITIDKVVVGQDTGMVVNPDGVRHQVH
GNVVQTLSRVLKEQVRFDADGVASREWGSYPLLTFPEIPPIEVLLMPRQSEPPLGAGESA
SLPGAPAIANALFDALGVRLRRPPFVPETVLAAMKSMASTNG
>A0A375J1V6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEARADAGVATLDRRSFLKLTGLAGGGLALGVAPLAQAQESGK
PKAPAAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVIT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVALVARPPRFGGKVKSFSADKARAVPGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSKVSSQALFDEYAKLAGQPGTVARAGEGAGGGDIAAAIQRAPRKIEAD
FRFPYLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLN
TMMAGGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHR
ARIGLDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVH
HPQVDVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQL
AVEKSGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNP
LSAEAQIQGACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDTPVVDVFFVPSQDN
PTGLGEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A375CBL5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MKLQLKINGKRHAVDAERDMPLLWVLRDYLGYTGTKFGCGAGLCGACTVHVDGKAVRACI
TPVGTVARADITTIEGLSADNSHPVQRAWIAEQVPQCGYCQSGMIMAACAWLKDNPSPRP
EDIRAGITNLCRCGTYPRIERAILRAATAQNAGDPKGRASS
>A0A7W7F619|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingosinicella soli|TrEMBL
MSAADDIINISRRSLLGAGGALVLAMALPRAASAEARKYGADAQPGGWRDDPALFVAIGD
DGAVTITCHRAEMGQGIRTSLAMVIADELEADWNRVRIEQAVGDETRYGNQNTDGSRSMR
HLFMPLRRCGAAARTMLEQAAAKRWNVPVAEVAASLHEVIHRPTGRKLGYGTLAKDAAAS
AVPDRATVALKVPAAFRYIGRDMHSADGLAMTTGRADYGIDARLPGMLYAVIARPPVYGG
KVKSVDKSAALKVAGVTDIVDLPAPALPSAFQPLGGVAVLATNTWAAMKGREALAITWDD
GPNAAYDSAAYRAELERSARAPGQVSRSDGDVETALGKAEKRIDAEYYTPHLAQAPMEPP
MALARTDAARCEAWACTQDPQAARDLIAEALKIPVADVTIHQTLLGGGFGRKSKPDFVLE
AALLSRTAKGRPVKLVWTRADDLHHSYFHTVSAARLEGGLDAAGRTVAWRHRSAAPSIAS
TFGPDPRHQMPFEQGMGLRNVPFAIPNVRIETCAATAHTRIGWFRSVSNIPHCFAVQSFV
AELAAAAGRDPKDYLLELIGPDRAIDPRAMGDTVNAGEDPALYPLDTARLKAVIAAAAKG
IGWGRALPPGRGLGIAAHYSFVSYTACAIEVWVADGQLTIERADIAVDCGPQVNPDRIRS
QMEGSVVMGISLATLGEISFKDGRVQQDNFDSYAITRIDAAPKITEVHLVGGGVWNTPPG
GVGEPGVPPVAPALCNAIHAATGKRIRSLPIGEQLKA
>A0A375BC35|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Cupriavidus taiwanensis|TrEMBL
MRIRGIEALAGGQAGNSGEARGDAGVATLDRRSFLKLTGLAGGGLALGVAPLAQAQEGAK
PKAPPAAPQAFLIIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDADWRNVRAALAPAG
DPYKDPGFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAAQRWKVDPASCKVEQGVIT
SGSQRATFGELAPAAMELPVPQQVTLKDPAQFRIVGKPTPRLDARGKMEATTPFGIDTQL
KGMVVAVVARPPRFGGKVKSFSADKARAVPGVRGVLQVPVDRGGSGVAVIASGYWPAKMG
RDALEVQWEDAGSKVSSQALFDEYAKLAGQPGTVARAGEGNIAAAINGAPRKIEADFRFP
YLAHAPMEPLNCTLQPEVAGGKVQSVKVWVGSQFQTVDQAAVARTLGLAPDKVVLNTMMA
GGGFGRRAVPTSDYIVEAANVLKAWVAAGHTEPLKVVWSREDDIRGGYYRPLHLHRARIG
LDAQGKVVGWQHTIVGQSILKGTPFEPFMVKNGVDATMTEGIVENDYDLPLQMSVHHPQV
DVPVLWWRSVGNTHTAFVKETLADEMAAAAKQDPVAFRLARLDEKKHARHRAALQLAVDK
SGYGKRKLPKGHAWGVAVHESFSTVVAYVVDVSLVKGEPRVHRVTAGVHANRVVNPLSAE
AQVQGACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSQDNPTGL
GEPGVPPIAPAVANALFTLTGKRQRQLPFVMA
>A0A7W5ED20|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Massilia umbonata|TrEMBL
MTNALPDASRRLWLKAGAAVAGGLLLQVAIPGRMARALPAEVTFTPNAFIRLDGDGKVTL
TMPYVEMGQGTYTSIPMLIAEELEVDLDQVVLEHAPADAGKYANPALGGQMTGGSTTMRA
AWMPMRQAGAVARILLVRAAASQWQVDPATCRAERGAVLHVASGRLLRYGQLAAAAARMP
VPNDRDIVLKPASEFRLIGTAAKRLDTKGKLDGSARYGIDVVLPGMKVAALAISPVRGGR
LVRLNEAAAMKIRGVRQVVRLDDCAAVVADNMSAANKGIAALSLEWDDGLHAGLTTEAIV
ADMAQAARGAGATVRSENNPEQALRGAARVLEATYELPFLAHTPMEPVNCTVHVRPDSCE
VWTGTQIMGAAHAVAARAAGLPPERVTVHNFLLGGGFGRRLEVDMIERAVRIGKAVPHPV
KVVWSREQDIQHDMFRPYFYDRMLAGLDAAGKPVAWTHHITGSSVLGRFMPGAFNNGFDA
ETVDGADAPPYAFPAIGVSYVRHEPPGVATAFWRGVGPAHNVFVVESFIDELAHAAGADQ
LRYRLDLLGHNPRARRVLELAADKAGWQGSKAGSTGRGLAVQFAFGTYMAMVADVVVGPE
GELRVPRVVCAVDCGVVINPDTVHAQVESAVVFGISAVLYGNVTIKNGRVEQSNFHDYRV
LRMHEAPVVETHIVASGEAPGGMGEPGTACVMPAVANAVHALAGKRIRKMPIGASLPA
>A0A679K0J2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Hyphomicrobium sp. ghe19|TrEMBL
MISLKINGQSRDVDTSPDTPLLWALRDLLGMTGTKFGCGIAQCGACTVHVDGEPVRSCQL
PIGSVGGRAITTIEGIGATGAGAKVQKAWLDLEVIQCGYCQSGQIMSAAALLAHTANPSD
DDIDAAMAGNICRCGTYVRIRAAIKKAAAA
>A0A1W6NW30|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Ketogulonicigenium robustum|TrEMBL
MADIKTQAGGLRRLGIGKANSLDLTRRGFLISAGLAGAAFGFPRSGLAAMDPATADGVPV
APTGSRFDPTIWYWIDASNKVNVHIKQAEMGQHVGTAIARILADELGANWEDVSIEHVDT
DPKWGFMMTGGSWSVSQSWPIYRQAGAAGRVALAEKAAALWNVDVATVTVANGTVTSGDH
TATFGELVADGIDRTFTEDELAALPLKDLSELTLVGKDVEALDIATKVNGKAIYGIDAKI
DGMVYGAPLIPPTRYGSVITEIDDSEAKSIRGYQQTLKLEDPSGIAPGFAVVIADSLWAA
KKAAKVIKVTWTPGFGADLGEDDFQAENARLIADPKSGSTLDVGDNDVDPIFASADSVLE
QTYTTATVLHFQMEPLNALAFRNDDGIWEVHTGNQAQSLTIPWLQTALGVGDGEVIMRSY
MLGGGFGRRLSGDYAVPAALASQMLDGRPVKLIFSREDDVAFDGPRSPSTSQFRMAFDAD
KKVLAMDTACASGWPTKANMPLGLAKGTNDEPYDPFAVDGADHWYETGGQRLRAISNDLA
VQTFRPGWLRSVAPGWTNFGVESFMDEAAHHAGVDPLQFRLDHLTAEGRNAGSTPLDKGG
AARQAAVLKRVAEISGYGNAVLPEGSSMGIATTFGQSRSMPTWVAAVVQIAVDKEWGEIK
VEKIWMVVDCGVVVDPDGAHAQLQGGALWGVSMALFEGTAFENGSVRDRNLATYTPLRLM
DTPPEINIELVESTEAPVGLGEPGVTVIAPAIANALFNGTGIRMRHLPMTADDVLAALEA
>A0A7W6XID2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR48|TrEMBL
MANLTINGKTFTLDVEPDTPLLWAIRENAGLTGTKYGCGIAQCGACTVHIEGVATRSCGV
SVSEAEGKKITTIEGLASGDALHKVQEAWIAQDVPQCGYCQSGMIMAVAALLSEKPKPTD
ADIDEAITNICRCGTFQQVREAIHTIASA
>A0A7W6U1D1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR48|TrEMBL
MNAHDSVSRRALLTGGLATGFLLAFHLPLRAAVNEPVQPRDATEGKFAPNAFIRIDETGH
TVLMMPQVEMGQGTYTSISAVLAEELDADWSRVEVQHAPPNDKLYGNPTFGLQVTGNSNS
IRAWWLPLRKAGATARAMLVQAAAAQWGVEPASCTASKGEVAHEASGRKLAYGALALAAQ
GQTPPKDVALKDPKDFVIIGQPLKRLDTPDKVNGKAVYGIDAILPGMKFATVAACPVFGG
KVGKVDDSAAVKLPGVRKVVVLDDMVAVIGDHMWAAKKGLEALKIEWNEGPNAAITTKDV
WDDLRKASQKDGAVAKSDGDIAKALASGDKFEAAYELPFLAHASMEPINATVHVKPDSCE
IWTGTQIMTRVQSEAAKAAGLPVDKVIVNNHLLGGGFGRKLEPDMVIAAVKIAKQVDYPV
KVVWTREEDIQHDVYRPVYRDQITASLVDGKVAGWKYKVAGSAVLARWLPPAFQKGIDID
AIDAAVDAPYDFANFHVEYVRAEPLSVPTGFWRGVGPNNNVFAVECAMDELARKAGKDPI
EFRKSMLTKNPRMLAVLGQVAEEADWGEPLPPRVGRGVCVQPSFASFIATVVEAEIDDIG
EIVLRRITSVVDTGIAVNPDTVKAQIEGGLIFGLTAALYGEITIDKGRVQQSNFHDYRMM
RINETPKIDVIVVKSGEAPGGIGEAGVNAGPPALRNAILAATGVALRRLPIDRKLLAAGK
KA
>A0A7W6U1A6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. CIR48|TrEMBL
MATVLTINGETKSFDAPPEMPLLWVLRDILGMTGTKFGCGIAQCGACTVHVDGKAVRSCV
LPVSAVENRAITTIEHVGSTPAGAKVQKAWLDLEVIQCGYCQSGQIMSAAALLAATPNPD
DSDIDAAMAGNICRCGTYVRIREAVKQAAHGRQS
>Q4KFT0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIDGDPARSCIT
PIGSVQGKNVSTIDNLHTDPVGQVVQQAWLDTAVAQCGYCQGGQIMSATALLKVHPNPSD
EQIEEAMLGNICRCGTYNRIKTAIRQASSHLQEAKA
>A0A839EXL7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Dokdonella fugitiva|TrEMBL
MKLVVNGQPHEVDAPADMPLLWVLRDILGMTGTKFGCGLAQCGACTVHLDGQAIRSCVMP
AVAAAGKSVTTIEGLSSDGSHPVQRAWQELDVVQCGYCQSGQIMSAAALIAQKPSPSDAD
IDAAMAGNLCRCGTYQRIRGAVHRAAELASKEGGHVA
>A0A0P7Z2J0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Porphyrobacter sp. HL-46|TrEMBL
MLMRDLGIIPAQRGGDTGDRSSPYVNLSRRAFVGGAGLFVLGVTLAGCSTYVEPEIDADA
FDLPDAGPSPLTEVRGGDATPALWIAIDKDGAVKITCHRSEMGQQVWTSMAQIVADELEA
DWDRVEIVQAEGHERYGDQNTDGSRSVRFNFHRLRVAGAAMRQMLVAAAALHWKLPQDQC
SAKGGLVSNSQNGETLSYGNLAELAGRLAIPAEADITLKTPREWRYINAEIPSLTVPRIV
KGEGTFGIDVTRPGMVHAVIARPPQLFGRVGSVDDAKALEVPGVLGTVRLPDAKPPALFQ
PLGGVAVVARDTWAAIEGRRALDIAWADGPNAGYDSETYAAQMQATARRSGKVRRSRGNV
AAALAAADKRVSAEYYAPHLGQTPMEPPSATAEWDGDRLECWACVQDPQSTRDTLAGALG
IDKELIKVTPTWLGGAFGRKSKPDFVIEAALIAREVGKPVKVTWTREDDIRHGYYHSVSA
QYCEGGLDKDGTCTAWLHRTVFPPISSTFDNSVAEPSDGELGMGASDVPFAAPNLRVESG
NAKGHVRIGWLRSVANIYHAFAVQSFAAELAHAAGRDQKDYLLELIGPPRMIDPEAEGAK
YGNYGASLEEYPIDTGRLRQVAEKAAGMAKWGRKLPDGHGLGIAVHRSFLSYIATVVEVA
VGKDGAIRIPGVWLAVDAGTVINPRHVRAQVEGGTIYGLSNALYGAITAKNGAVVQDNFP
SWRVLRMNEAPRDFEVAIIASDAPPGGVGEPATPPAAPALANAIFAATGHRLRSLPFIGA
DGDKLKLPPRQPV
>A0A3G7K3D1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas chlororaphis subsp. aurantiaca|TrEMBL
MTFILNGRHLLLDQLPPNTPLLYALRNDLGLNGPKYGCGLGQCGACTVLVDGVAARSCTL
PLSSVQGKQVTTLEGLAQEERLHPVQQAFIDEQAAQCGYCSNGMIMTLVALFEREPEADE
QRIKNELAYNLCRCGAHFEILQAAARARQLLAERGRP
>A0A0Q0KJR0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella sp. P1-14-1|TrEMBL
MSQEMQTLEINGKSFTLDADPNMPILWALRDILGLTGTKYGCGAGLCGACTVHVDGKPVR
GCLTSIKQAAGKSVTTIEGLEADKLKAAWEKHNVPQCGYCQAGQLMSAAALLSTTAKPSD
AQIDDAMSGNICRCGTYPRIKAAINTAADNSKVEA
>A0A1V0RUA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Roseovarius mucosus|TrEMBL
MRFTLNGLGQDIPADWADEPLLVLLREHIGLTGAKFGCGVGICGACTIIVDGAATRACMI
RSGDIEGLNVRTIEGLADGDSLHPVQQAWLDLGVPQCGYCQAGQIMAAVALLEETPDPSE
DDIDAAMDGNLCRCGTYPRIRAAIARAAERV
>A0A846U9P4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobacter sp. SG703|TrEMBL
MSTRFKINGKAVDVKAEPDTPLLWVIRDEIGLTGTKYGCGMALCGACTVHLDGQPVRSCQ
TPVSAVAGKSVATVESLSRNNSHPLQVAWIKHDVPQCGYCQSGQLMSAAALLKENKNPSD
AEIDAAMSGNICRCGTYPRIRAAIKSAAADMQHHKA
>A0A0J9E7T7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Candidatus Rhodobacter lobularis|TrEMBL
MGRLRTIGRRSFLIGSAAVMGGVAFGTYMVQAPHDNPLAKDLAEGSATFNPWVLISPEKI
TLIAPHADKGQGVSSAQAALIAEELDVEFGQFEVSFGKPDPAYWNHAMSEEGLPFKSTDD
RWAVERARATMGGALKVMGMQGTGGSTAMADSFHKLREAGAAARETLKLAASNRTGVPVS
ELKTANAAVQLPDGTEIKYTELAGEAAQIEPVRFVKLRDPSEWRLIGKPMQRLDILGKST
GTLDYGIDVEIEGMVHATICVNPRQGGVMKGYKENGAREMRGVIDIVEITNGVAVVADNT
WRAFQAINAIECDWGDAPYPHEQADHWTAIEDSFVEAQLDDEWRNDGDVDAASGEEITAE
YRSPYVAHAPMEPLNAIVQVTDARVDIWTGHQMPIILEQQIAALTEHDVENVHFHNQWIG
GSFGHRLELDYIKQAAEIANQMRGTPVKMTYTREEDFAHDFPRHIAMGRASGKVADGKVV
SMSLDIAAPSVLGSQMSRVGITVPGADAQIPAGSWNNPYALANFRMRSYRAPELAPVSSW
RAVGAPGAGFFFDSFLDELIHAAGADPMEERLRLINHKPSRKVLEEVAALSNWGSEMGEN
QGRGVAFIESFGAPVAEVIEVTQSDAGIKIDKAFVVADVGTVVDPINFENLVMGGAIFGM
GHAMNCEITYSDGMAEQSNYHAHEAMRMYQCPEIVIKGLENGHKIRGMGEPTVPPAAPAL
GNAIFAATGQRIREMPFHKHIDFV
>A0A0H3KRD2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia multivorans (strain ATCC 17616 / 249)|TrEMBL
MVTLNINGETRTVDAPDDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAARSCVL
PVAAVAGRRITTIEAVGATPAGQKVQQAWRALDVVQCGYCQSGQVMAAAALIASNPKPSD
ADIDAAMAGNICRCGTYHRIRAAIKQAAQEA
>A0A6S7BNC9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia ultramafica|TrEMBL
MLKRRTFLLGGAGAVGALLVGWSVLPPRQRLNTSAPLPTQGSQVALNGWVKIAADNSVTI
VMCKAEMGQGIHTGLAMLLAEELDADWSQVRVEEAPIDKIYNSVQSIIDDLPFRPDDDST
LKRTTVWFTRKAVREAGTMMTGGSSSINDLWTPMREAGASARAMLIGAAAAQWSVPPGEC
RAETGHVLHASGHKASFGELSSLAAQQALPRKVELKNPADFKLIGQPVRRIEAASKINGT
ARFGIDALPDGLLYASVVMCPTLGGTVAHFDATSAQKMPGFIKAIAVAPYSGGSGGVAVI
ADNPFRAMNAVDAINVTWHDGAGATVSSAEVGRRLAQALDDSDGHAYFHRGDVDAALSSA
ARTVDAEYYAPYLAHGAVEPVNCTVQVADGAATVWVSTQMPALARQHVAKVLDIDADKVD
LQTQLVGGAFGRRLELDFIAQAAAIAREGGGHPVQTIWSRAQDFTHDFYRPACVSRLKAG
FDANGKLVVWHGTSASQAIVPESLARYYGVPRIPIDKTTCEGAFDQPYEWPTARVAHKIV
ELPVPVGFWRSVGHSHQAFFTESFTDELAAATGQDPIAFRAALLAQHPRHLAVLKRVAAL
SEWGRPLQHAADGAPRARGVALHEAFGSVVAQVAEVSLGPNKLIRVHRVVCVIDCGLPVN
PNLIRQQMESGIVFGLSAALQDEIVIINGQVQQKNFVDFPVVRMNDCPVIETDIMPSQMH
PQGVGEPAVPPIAPAVANAVFALTGKRLRTLPLRLA
>A0A846MUT4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizomicrobium palustre|TrEMBL
MQYRLNVNGADHNVEVDPDTPLLWVLRDAMNLKGTKYGCGSGLCGACTVHVDGAPVRACM
TEISSLGTKKVTTIEGIGTTAVGKRVQEAWLKIDVMQCGYCQPGQIMEATALLAKTPKPS
DAEITDAMGSHLCRCGTYTRIRAAIKLAAEG
>A0A1P8UMW0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger abyssi|TrEMBL
MGIMQKLTRQPVNVSRRGFLTGTGALVLATALPARRSRAQEAAGEAEPPAVPAFLELRAD
GTALFRSPFIEGGQGIFSALPQIVGEELDLHPELFTVESAPPGAPFDIMGGFRFTGGSSS
VRSSYPLMRQLGATARAMLIEAAAQQWGVDAADLTTEPGKVVNPESGESLGYGELAGAAM
DLPVPADVPLRDPSTFRWIRQPLPRYDVHDKSTGRANYAIDASVEGMLLAAVQHAPRLGL
APVSVTNRAEIEGMRGVHSVHLLPGAVAVVADKFWQARKAVEAAEVEWGPGEASWPMPED
FSSQGFRDTLANADGEVIEIEAQGDAAGTLAGAETVLEAEYDAPFLVHGQLEPPSTIARF
NDDGTLDLWLPNQAPEMFQGAAAEIAGVAAENIRIHSQILGGFFGRHFLYETANPYPQAI
MLAKAVGRPVKVQWTREEEFLRDAVRPMGFARFRGAVSAEGPTALSVEVVGEGPTGRWYK
APAGQDPSATEGISGKTYAIANRHIGQIYVPNPAVIGYWRAVGHSMHDFMYESFLDEMAA
AAGLDPFEMRRGLLSDSERHRTLLETVGTLSGGWKPGVFESEDGSQRARGVAMASPFGSE
VAVIAEVSIDGGEVAVHQVWVAIDPGQIVNPATIEAQVQSAVALGVSQTLMEELVYENGE
PTARNFDYYPFLRPDQMPQVHVEIVESGAKMGGIGEPGLPAVGPAIVNAVAVLTGQRIRS
LPLSKHDFG
>E3FRZ6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Stigmatella aurantiaca (strain DW4/3-1)|TrEMBL
MSHTQPMLIARRSFLAGLNLSVGGLALGLFSNEGLAAEPSGQTGAKPKAGSKAQETSAPG
LNPNAFVHVAPDGVVTIVCHRSEMGQGIRSSLPVLIADELGADMAQVKILQADGDPIYGD
QNTDGSNSVRGIYTDMRRVGATARTMLVAAAAKRWKVSPDDCEAVDHVVVHRGSQRTLGF
GELALEASKQRVPKADQVKLRPKNELRRVGKHLPLIDGPAYVTGTAVFGADVRLPGMLTA
MVARPPVVGGRVARFDAARALAVPGVKRVIELPVPTKPYQFQSWGGIAVLAENTWAAMKG
RGALDITWEDGENASYDSEQYRQELLASVRAPGTVVRNVGDAEGALAQAARVVEAEYYVP
HLSHAPMEPPVVVARVEGGTCEVWAPTQHPQAARTEAARALGLPVEKVTVHVTFLGGGFG
RKSKADFVSEAVLLAREAGVPVRVQWTREDDIRHDYYHAVSTQRLSAGLDAQGKVIAWRH
RTAFPPIGSIFGPVNRPAEGDLQQGVLDLALAVPNLRAEACEANAHVRIGWLRSVYNIFH
AFSVNSFIDEIAHTRGEDPRDVLLEMYGPPRVVNTLEALGIKSLRNYGRPLEEHPIDVGR
MRNVIERVTQLARWDERKKDGRALGLAAHRSFLSYVAVVASVIRGPGGKLAVDEAWLVID
AGTVINPDRARSQMEGSIIFGMSVAMYGAITMKGGAVQQSNFHDYRLMRIGEAPRKINVE
IVPSEALPGGIGEPGVPPVAPAIANALFALTGTRVRELPLSRIPPVS
>A0A7W6CHM5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium sediminicola|TrEMBL
MIELTINGQKRRVDAESDTPLLWVLRDDLGMTGTKYGCGVAQCGACSVLVDGSVMRSCVT
PVEAVAGRKVTTIEAMEKDAVGAKVVEAWVKHQVPQCGYCQSGQVMAATSLLKQNAKPTD
ADVEAAMVNLCRCGTYNAIKAAVRDVAGLEAKA
>A0A840ZZ48|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum rhodesianum|TrEMBL
MAAMIKLTVNGAERSFDGDPEMPLLWYLRDELGLTGTKFGCGIAQCGACTVHLGGTAARA
CITPVSAAEGQEITTIEGLSPDGNHPVQVAWRDLNVAQCGYCQTGQIMQAASLLKDTPKP
TDQQIDENMSGNICRCGTYPRIRAAIHQAAGQAPASKGDRL
>A0A3N6HLX0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Streptomyces sp. ADI97-07|TrEMBL
MPKHTFRLNGEQVTVDIADDVRLLWVLRDILGVTGPKYGCGINVCKACTSHLNGRAVNPC
AIPVGDLNPTDEVTTIEGLPGTVGADLHPMQQAWLDQDVAQCGYCQPGQIMAAVALVRRA
AEEGREITEADLDGIRNICRCGTYLRIREAIKAGARSM
>A0A7Y9ISG0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pigmentiphaga litoralis|TrEMBL
MVDFSLNGQKVSVQAPADKPLLWVLREELKLTGTKFGCGVAQCGACTVHLNGQPTRSCVL
PVSAVAGADITTIEGLVKTDVGRRLYDAWVDHQVPQCGYCQSGQLMTAANVISSATAPLL
RADVLEKMQGNLCRCATYNQIASAVISAGTTASGANNAR
>A0A7Y9ISK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pigmentiphaga litoralis|TrEMBL
MTDIVTPAAIDSPTRRRFLQVGAAAGGGLLIGFGLTACSREDRNAKPPEAAVGHATTNVT
GDAPALAQRAFIRIDRQGVVTLIVHKTEMGQGTYTSMPMLIAEELEVDLSQVKLEHAPAD
NSLYSDPLLGGQVTGGSTSIRGGWQPMREAGAAARIVLIGAAAQAWKVDAGECQARNGKV
THTATGRTMHYGELVDAAAKMDTPKTITLKKPDEFTVIGKSLKRLDSPEKVNGQAKFGID
VRLPNMLVATVAACPVPGGKLQAADEAKAMAVKGVRHVLKLDNAVAVVGDHMWAAKQGLA
ALDPTWSDGPNAAMTTATIVADMKTASNTAGVVARNDGDANKEAPKGGQRLEAVYEMPFL
AHATMEPMNCTVDLRADGCDLWLGTQVPALAQGAAAKLTGLTNDQVKVHNHFIGGGFGRR
LEVDMVTQAVAFAKQVKQPVKFVWTREEDIQHDMYRPYYYDRLSATIDDKGMPQSWSHRI
TGSSIMARFAPAAMKDGLDPDAVEGARDMPYKIPNVHVDYVRHEPPVPTAFWRGVGPTHN
IWVVESFIDELAAASKQDPVAYRRELLDKSPRLRQVLNLAAEKANWGTPARAVEGHRVGR
GVSAQFAFGSYIAQVIDVAVDPAGEVKVTRVVCAVDCGQLVNPDTVMAQIESGVVFGLTA
ALWNEITFDKGRVQQSNFGDYRMMRLNEAPRIEVVLAKSTDDPGGIGEPGTAATAPALTN
AIFAATGQRIRKLPVSSAQLKTA
>A0A0A1HSA2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. SHC52|TrEMBL
MLNDIFPDELPRALQSIFTDDDLGSLTTLPRRSFLKIVGIGGLALGAFPHLALAQQAGDN
GQALKPTQQPSAFVQIAPNGEVTVTLNRLEFGQGVQTGLPMILAEELDADWSLVRTRNGS
NDAAYQDPSFGMHITGGSNSIKNSYTQYRELGARARAMLLAAAAARWNVDAASLSTQAGM
VLGPGGRKASYGELAEAAMAMPVPEAITLKDPKDFRIIGQATTRIDAKAKSSGRQDFGID
MHLPGQLTAVVARPPVFGARIASLDDSAARATQGVKAVLRVPLDGGAEGVAVVADGYWQA
KTGRDALKLQWDTSAVEKVDSEKQLAQYRDLASQPGPLHFDADMTPLASAPHQLEAEFLF
PYLAHAPMEPLNCTVQVTGDRAQLWVGTQFPGGDGVAAARVLNLKPEQVQVNVQTAGGGF
GRRGVPSGDFVVLACEVAKAARTAGLDAPVRTLWSREDDIKGGYYRPMHLHRARIGFDDN
GNVLAWDHVLVGQSILADTMFDARVKNGIDPTATEGLRNPYPLPMRLTVHHPKFNVPVLW
WRSVGSTHTAFVMETLIDEIARTTRQDPVAYRMKLFADQSPRHRAALQLAVDKSGYGKAQ
LPEGRAWGVAVHESFSSVVAYVVQASVQNGRPVLHQVTAGVHCNLAVNPRSVEAQVQGAA
LMGLSMCLPGGAVTLKDGVVQQSNFADFSVPRITDTPEFSIHIVPSADPPTGMGEPGLPA
LAPAFANAVASLTGKPLRQLPFKLA
>G3J178|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacter tundripaludum (strain ATCC BAA-1195 / DSM 17260 / SV96)|TrEMBL
MSKYKLNINGVQKTVDVAAETPLLWVLRDHLNLVGTKFGCGIGQCGACTVHIDGQPTRAC
LTPISSVGKSQITTIEGLNPNGEHPLQKVWQELDVPQCGYCQAGQIMTAAALLKKNPRPT
DADIDTALAGNLCRCGTYLRIRAGIHRAAEIVAKESV
>G3J1Z6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylobacter tundripaludum (strain ATCC BAA-1195 / DSM 17260 / SV96)|TrEMBL
MITFNINGKPRQIDLPTDTPLLWVLRDHLGLIGTKFGCGMALCGACTVHLDGEPTRACVT
PISAAVGKKIVTIEAIDQDATGQKVQEAWLTLGVPQCGYCQPGQIMAATALLKQKPKPTD
ADIDKAMSGNICRCGTYCRIRAAIKQVAGLTEVKP
>A0A3R7HN05|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia sediminicola|TrEMBL
MTTFNINGQTHTVDAPPDMPLLWVLRDLVGLTGTKFGCGIAQCGACTVHLDGVAVRSCVL
PAAAVGDKKITTIEAVGSTPAGQKVQQAWRQLDVVQCGYCQSGQVMSAASLIASNPNPTD
ADIDAAMAGNICRCGTYNRIRAAIKQAAKGA
>A0A177HAL8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhodobacteraceae bacterium SB2|TrEMBL
MSRLGKIARRTFLIGSAAVVGGVAFGVYKYRSEGENPLLDDLGANEAAITPYVKIDANGI
TLITPRADKGQGAYSIQAALIAEELDVDLDQINVDPGPPSATYYNTAYAREAVPFKPTDD
GVMAQSMRTVADAAMKFIGLQITGGSTTVPDGYEKLRQAGAVARETLKAAAHEKTGVHVT
RMKTRSGHVILPDGQELSYQSLASAAADMDPVRDVELRAESKWRYIGKPMQRLDIQAKST
GTQNYGIDFELPGMLHATVKLNPHQGGATATDYDATDALNMRGVQGVHPVMNGIAVVADN
TWRAFQAAEMINANWPKSDMPDTMEGHWQALSDAFNEDQQEIQNRDDGDVEADLAKGDVL
TAEYRAPYVAHAPLEPINATVLMTDDRIDIWTGTQIPRFIEKNVAKLTGFERHQIHLHVL
MMGGSFGHRLEDDVARQAVQVATEYKGTPIKLTYRREEDMMHDYTRQIAMARASGRVANG
QVSALDLGIAMPSVVASQMARQGLSLPGPDAIIVTGAWEQPFDVPNYRVTGYRAKPLAPL
SSWRSVGASTNAFFHEGMMDELIRAAGADPLAERLRLCSHDPSRKVLEKVGEMSNWGTPL
GENRGRGLAFCLSFGVATAEVVDITVTEDGIRIDDVYTAAEVGKVVDPINFDNLVKGGVI
YGLGHAMNCEITYTDGIAEQDNFWSHEGMRMHQTPRIHVVGLENGSKIRGIGEPPVPPAA
PALANAIFDATGQRLREMPFSKFVDFA
>H1KSG3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylorubrum extorquens DSM 13060|TrEMBL
MISLSINGHQHSIDVEPDTPLLFVLRDTIGLTGTKYGCGIGQCGACTVLIDGQAIRSCQM
PVESVGAQTVTTIEAIEADPVGARVVAAWVGIEVPQCGYCQSGQVMAATGLLKETPKPSE
DAIAAAMTNLCRCGTYNAIAAAVRQAAA
>A0A840NDH4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Saccharopolyspora gloriosae|TrEMBL
MSTHTFIVNGESVTVDVDDKERMLWVLRDVLGIRGPKYGCGINVCKACTSHINGKAFNPC
AVPVGDLEPTDEVTTIEGLPDTVGKDLHPMQEAWLEHDVAQCGYCQPGQIMAAVAKVNQA
RAEGREIDDALLDEIRNVCRCGTYFRIRQAIRSGAENM
>A0A2X5PEP6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tatumella ptyseos|TrEMBL
MEMKAQQSVTQVSPAGLRCYSLKVNGEEREVTSYRDTSLLLVLRNELSLNSPKYGCGLGE
CGACTVLIDGVAARSCVIPAFGVRQRAVTTLEGLGSRYALHPVQQAFIEEQAAQCGYCLN
GMIMTTAALLRDLPCPSDLQIRSALSGNLCRCGTHQEILCAVKRAVQLSLQQAEAPQ
>A0A840S324|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Inhella inkyongensis|TrEMBL
MTSLTLNGKAQRCEADPATPLLWVLRDELGLTGTKFGCGIAQCGACTVHYNGQATRSCVL
PLSAAAGAQVQTIEGVGTDPIGRLVQQAWVELDVAQCGYCQSGQVMAAVALLKQTPRPTD
AQIDAAMSGNLCRCGAYVRIRAAIHAAAAHLS
>A0A3G7UR94|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas synxantha|TrEMBL
MTSQPITVTLEVNGQTSEVSAMADTPLLLVLRNDLQLNGPKYGCGLGECGACTVIIDGVA
ARSCVFPLVGAAGRRIVTLEGLGTRQAPHPVQQAFIDEQAAQCGYCLNGMIMTAKALLDR
NPKPSETQVRNELSGNLCRCGTHIEILRAVLRAARLMNVDG
>A0A1U7CZW2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Salipiger profundus|TrEMBL
MPITLTVNGTDHAVDLPAEVPLLWVLRDALSLTGTKYGCGVAACGACTVQIDGEAVRSCQ
VALGDVWGPVTTIEGLGTPDRLSRLQQAWIDHQVAQCGYCQSGQIMQAAALLSVTPHPTD
AEIDATMSGNLCRCGTYPRIRAAIRSAAGSEG
>A0A1J5NC97|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudodesulfovibrio hydrargyri|TrEMBL
MIVINVNGKDHRVDVDPDTPLLWVLRDDIGVTSVKYGCGEGMCGVCTVLIDGAAERSCVT
PVSSVGESKVVTIEGLPEDHPVKQAWIEHQVPQCGYCQPGMMLQAVDVLSGGKAMSDADL
ATAMDDFTCRCGTHPRVLPAMKQAAQTMKKGGKS
>A0A3B0RHA3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MGKWTRRAFIGAGVVAGGALVVGIAVRPGDPTKELKPLLANGEGEEMLNAWVKIGADNKV
TAIVPHAEMGQGAHSVLAQMLADEMDADWDNLEIVEAPGHSAYAGADLGREFIAPTLEVP
DLLEPTVQGTFLRLTNMMDLQITGGSFSIRSSGQRGLRTAGAAARHMLVAAAAEKWDVPA
AEISTGKSTLTHKGSGKTATYGEFAAAAAEQDLPVRPPRKKVEEFALMGKSIKRKDIPAK
VNGTAGFGIDANVPGMKYAAVKAPPVIGASVEKIDTTRAKAMPGVLQILNMGDFVAVVAD
GYWQAQQALDTIDTSYSKTDGQKLDLAAVFARYAEALDKAGNDGGDIETDEGDAVDAFAK
ASKKVTAEYKVPFLAHATMEPMNCTASVIDGKCQLWTGTQNPLGARRDVAKALGLDEDNV
SLNNAYLGGGFGRRSSTDVPIMAARIAKAAGYPVKMIWSREEDTRQDLYRPSATSRFEAG
LDANGSVVSWNNVHTHLFDPQEAPQVSHYAIPNHLIRKVDVPMHLRFGPWRSVDHSQQAW
FIESFVDEIAQAAGKDPLEMRRELLKKSPRHLAVLNKAAEMANWGSAMPDGHGRGIALVP
SFGSIVAEVAEVDMTGKKPRLAKVFCCADVGFAMNPDGVAAQMESAIVYGLTAALYGEIS
IKDGAVEQSNFHDYEMLRINEMPEVEVALINGDHERLGGAGEPGLPPLAPALTNAVFAAT
GKRVRELPLAKHSFA
>A0A3B0S2L0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|hydrothermal vent metagenome|TrEMBL
MTSQSGVKKITRRGFLVKTGWVAAGITVLGAVSFPTVRANLPTIPTTNNPELDDGMAWIQ
VLPGGKIRFFCPRMEMGQGAVLGLSQVVAEELNIDQSEIECLLPSTDQTPPFKMTVGSES
ILEFFNPVSLAGARLREILRDLAAKKAGIKGDQIKDARGGFILPDGSRLGYGDLVPSSPL
VVSPQDWAGQKKEAPLYAQKRQGEFAAIGKAWKPQDLEAIVTGKAVYSRDALVPGMMFGQ
VLRAPAFGARLKKVDSSAAEAMTGIRVVVGDEGNNFAGVVNFVAVVAADPFLLPEAIEAL
QVEWTIPDVANQYQLDKTLDVERLRAGDDFEHVVDEAGNSTQGRSEAKFLTTARYDTPFA
AHAAIEPRASVVSVRAEKIEVWCASQDPFYVRGRVAAVVGRSVDEVVVHSHRIGGGFGGR
VLCQASEEAAILSAAVGAPVRVQWDRKSEFQNNYLQPAFSHHINAGVKADGKISHWQHDF
VSSPIIFGQIPKNVAWAMDKVVADFGTSRGSKPPYQINNRRTRFSDIRTPVSIGAWRGLG
AAPNAFAIESMMDELASGAGIDPLEFRLNNLPASGSRLADVLRRVAEISGWGQPLAKDHG
RGLACSVYKGDTPVAVVAEVQVDRAAKKIRVTKVWCAQDCGLVLNPHQVENQVMGNIVWG
TSMAMKEQITIADGQVQEENFDAYEILRHDEAPQIVIDLVEPAGAKPVGVGEAALPAVPA
AIANAVFAATGRRVRRLPISYDSVVA
>A0A7W4Z4G4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Litorivivens lipolytica|TrEMBL
MTKETVVFTVNDRVEQTVVSPEKPLLWVLRDELDLTGSKYGCGRALCGACTVHVDGQPTR
ACVTPVKAVEGKRVTTIEALSETELGARVQRAWKSLNVPQCGYCQSGQIMAVVALLRAIP
KPTDQNIDEALSGNICRCGMYPRIRKAVHELAAGGFA
>A0A4U8Z3I4|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Methylocella tundrae|TrEMBL
MMIKTTVNGKARTFDGDPDTPLLWYLRDELGLTGTKFGCGQALCGACTIHLGGTATRACA
TPISSAEGQQITTIEGLSPDGNHPVQIAWRELNVAQCGYCQAGQIMQAASLLKESPKPTD
EEIDNGMSGNLCRCGTYPRIRAAIKQAANAAANSSKGGL
>A0A7S4LW78|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Serratia sp. Tan611|TrEMBL
MNSMEITRRRLLQAGGLVMVSSLLPVSFDALSATPAPRPASPPPDRVDSFIALSADGKVT
AFNGHVDLGTGVKTALSQIVADELDVDLAAVTMILGDTRRTPNQGPTIASATIQVTSIPL
RQAAAQVRQHLLQLAARAFNLPEKQLAAERGYVFERANRARRLSYGELARGQDLHLPLDT
TAPLKEHAQSRYVGRPVARVDIPAKVTGGLSYVHDVRVPGMLHGRVIRPPYAGADSSAPL
GKALVSVDAASIAHLPGIVKLVVINDFIGVIAEREEQAIAAMNQLRVTWRDWQGLPDLAA
GLHDTLTTHPKQDRMLQDDAGIEQIISALPTPVNADYLWPFHLHASIGPSCAVADVRDGQ
AEIWSGSQNPHDLRKDIAKLLDLTDEQVHIQRLDASGCYGRNGADDVSADAALLSQAVGK
PVRVQLMREQENGWEPKGTAQLIRVRGGLDAAHQVAAYDFKTCYPSNNAVTLALVLSGKV
ANQADVQQMGDRTAIPQYRYPHMRVVAQDAAPIVRASWMRGVSALPNVFAHESWIDELAY
LAGDDPIAYRLRYLDDPRALALIDALKKQADWQPGRAHRHPAPASQEWVSGRGFAYARYF
HSKFPGFGAAWAAWVCDVMVSRRTGQVKVKKVFVAHDCGRIVNPAGVRHQVHGNVIQSTS
RVLKEFATFDGAGTTSLEWGGYPILRFDELPEVDVQLLDNPDRPPMGAGESASVPSAAAI
ANALFDALGVRLREVPFTPERILQALTSAH
>A0A7W7MKM2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinoplanes lobatus|TrEMBL
MPEHTFRVNGAQVTVDVDSDVRLLWVLRDILGVTGPKYGCGINVCKACTSHLNGRAFNPC
AVPVRDLGPGDEVTTIEGLAATAGADLHPMQQAWLDHDVVQCGYCQPGQIMAAVDLVRRV
AAEGREITDADLDGIRNICRCGTYARIREAIRAAAASGG
>A0A1S6HMX7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Shewanella psychrophila|TrEMBL
MSSFTATQNFSRRDVLKLFGATGGGLALGASGLGWSPMVMAQNADSRLNLFIAIGEDNKV
YLTCHRSEMGQGIRTGIPQVLADELGADWDNVVVVQGLADKRYGSQNTDGSRSIRKGFDK
MREMGALARTMLEQAAADRWQVELSEVSTSNNRVSHAKSGKSATFGELAMAASKVKLPDV
KTLSLKPVSEYTHIGASHTIVDMQDMLTGKAQYGYDVQVDGMLCASITRPPVFGSEVAKL
DDAAARKVAGVVDVIQLSPTKGAPMFHPLGGVAVIASNSWSALEGRKALKIAWSASSNDD
HDSQVYLNTLKDRVTQPGKLMRQQGKEVTDWPAESTVSALYTVPYLAHAPMEAPSATASV
TASGCEVWASTQTPQSVQQNVAGALGLKEEQVKVNVTLLGGGFGRKSKPDYCVEAALLSK
KAGSPVKVCWSREDEIQNGYLHAISAQHYQAKLGSDKMPEAILQRSGFPSIGSTFSEGAD
YPAGWELDLGFVDVPLAVKSLRCEAVKAEAHTRIGWMRSVCNIQHAFGIGSFVDELAVKA
NKPCTVMWKALLGEVRQETFANQAFKYGNYGEDLARHPVDIARYRGVIDAVEQAMDKAGV
AGKNQGWGFAVHRSFTAFVATALLVQVSEDKQLKVLKAISAIDAGTVVNPDRVKSQTEGA
VMFGLSLAMMGEIDFKDGHVVQSNFHDYPMLRMPQCPEIETIVIESEAPPAGVGEPGVPP
VAPSLTNAIFAASGMRIRDLPVSKLLTV
>A0A0P8B465|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Marinobacter excellens HL-55|TrEMBL
MAFSLTVNGHRHTVDVDPDTPLLWVVRDEIGLKGTKFGCGAGLCGACTVHVNGQPARSCS
TPIELVDGADITTIEGLETEGRLHPLQQAWIDEGVPQCGYCQSGQIMTAAHLLANNASPS
RDEIVTAMTGNLCRCGTYARIVAAVEAVAGGVGQYEPAPEDA
>I0K760|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Fibrella aestuarina BUZ 2|TrEMBL
MATVKLTINNQPQTLDVDPDMPLLWAIRDVVGLTGTKFGCGIGQCGACTVHLDGAPIRSC
SVPVSAAKGQKITTIEGLSKNADHPVQKAWIEHQVPQCGYCQSGQIMSAVALLKQVPKPT
DADIDAAMQGNICRCGTYVRVRQAIHTASAELNTTQKLPKTAAKLGKR
>A0A161V372|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. WM33|TrEMBL
MSRLGKYTRRAFLGLGVAAAGGLAVGFYFYQKPYANPLDAKKAEGETPFNPYVMIDQDNT
ITIIAPRAEMGQGVHTTLAALVAEELEVPLEQVVVEHGPSSPAYFNAAMLEESTPFPFYD
ESVLAELARGSMKIVAKFLGLNMTGGSSSTTDAFLKMREAGYAAKFVLLKAAAEHFGTSE
DNLTLADGTITDTASGKSVTYGELASKAAAVSPPSEMKLKKASDWKILGKSQKRVELKDK
VTGGRIFGIDVQLPNMLYGTVKMAPRKGVSLKSYDKTATLAIPGVKDVVEIRTITGEGLG
VVADNTWAAFKGAEALEIEWDDPLSLQNSDQMWSVLENALTQEATFELGGTGSDADAFTS
ISESEAVSAQYRVPFLAHATMEPMNATAQHDENTIRVWTGTQAPGLIQSVVSSHFDMDSA
DIDVTTTRLGGGFGRRLEVDFALYAAVIAKATAPNPVKVTWTREEDTQHDTYRPMAIGQF
KGQVTPDGRLKTMDMQVASPSIIQSVMPRIFPGISPAGPDNTVLDGAFNQPLDVENIRCQ
AHVADLQVPIGFWRSVGNSVNGFFHESFMDEAAHKAGKDPLEFRLAHLTSDEFRPAREAL
KRVAEMSGWGTPLPAGKGRGIAHVLSFGTWTAQVVQVDVTDNTVTIEEVWAVADPGIVLD
PGIFKDQIMSGINFGLSQALGQEITWVVGEIEQANFDTFDAMRMYQAPKITIELLENSPR
MGGAGEPGTPPSTPALANAIFAATGKRIRQMPLSNEIHFI
>A0A839U2M6|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Phyllobacterium trifolii|TrEMBL
MSIHDKVNVSVSRRHFLIGTSLTGAGLVFGLRPSISSAAAAGFEPNPFIRIPADGKIVLI
MPAAEMGQGIYTSIAMLLAEELEVPLDQVVLEHAPADPARYANPLLGDQITGGSLSIRGV
YEQMRKAGASARMVLINTAARGWDVAPDTCTAEAGEVVHAASGRTAAYGSLIRAAAAETV
PQDVPLKPSSSFKVIGQAIRRLDSPQKVNGTAKFGIDARPEGVSYAAIAICPHFGGKLRS
VDDKPAMAVKGVKQVVRIEDAVAVVADNTGAARKGLAALSIEWDPGPSGDLTSAELEKRV
EDATNGGKALPHINEGDVAKAEAEHGPVHEFVYRMPILTHSAMEPMNCTLHVRKDSCDVW
TGTQVAGRARQAVADVTGLPLDKVVVHNQLLGGGFGRRLDVDGVILAAKIAKQVDGPVKI
TWSREEDIRHDCYRYLNYSKVSATLGPDGMPVSWRHRVIGPAVMARWLPAFTKDGIDLDI
MGGAESSYAIPNKFTEFVRHEAPDGMLTGNWRGVGATRNIFPIEGSIDELATAAKIDPLE
YRKRLLQHKPRLLGALDLAAEKAGWSNALSQGKGRGIALSEDFGSFAAMISEVSIGDDGK
PKVERIVCAVDCGQVVNPDTVDAQILSGIVYGLSAALYGRLTVQNGAVVESNFDDSPVLR
IHETPRIEVYIIPSSEAPGGIGEVGTPGVAPSLFNAIFAATGKRLRSLPIDQHEFQRV
>A0A7W7Q834|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Actinophytocola algeriensis|TrEMBL
MTGTNGERVGRRRFLGYVLAAPTLVTAAEFGLAPVAASAPAPASGAQLPSPDITDVIDLN
DMMTLAALPTSGLISVEVNQDGTVSFALPRAEVGQGITTSTAMLIAEELSVPLDRVRVTL
ADARLELVFNQLTGGSNTTFATYTPIRVAAAIARRRLLDAAATELGSAVTDLTLDTGVIT
DRSGRSVDIGALAEKAASTRNQQVPVELTARANFTVIGKPHNRIDALAAVTGRKKFAMDL
DVPDAKPTMVCRAPTINGTVRSVANLGEVRAMPGVTDVVVISTGVAVRAETFGQCVDGVR
ALRVTWKPGTAEGKSDDIVLRELERAELPLGLPSPMPTVEAKFTFFFRGNSALEPNCAVA
DVRADRAEIWSSLKSPIVAKQTLAAKLGLPPSRVTVHVVEGGGSFGRKLFFDAALEAAEV
SQKVGRPVKLMWHRADDSRQGRTHPMATSRVRASYLGDTVLGYHQRHTSVATDLGHGLGE
IITATAAQLPVGDIGFSETFFQLSQTMSYNFGISTRLLSETDKGFNTGSMRNVYSPDVTC
ARELIVDQLAARMGKNPYRFRRDFLRDERSRAVLDKVAEVGQWGRAMPAGTAQGIAFHAE
YKAVSAALIEIDCRPETVNRPIRDGVTGPRVTKVVFAVDVGLAVNPRGLEAQMMGCISDG
IALALTSSLHLRDGYFLEASWDNYFYTRQWNTPPDLQIIVMPSTSENPGGAGELGVAASM
AAVACAYGRATGTMPTSFPINHGTLSFTPKPTVPPIPPSPTDGLEHAR
>A0A6J4L632|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|uncultured Microvirga sp|TrEMBL
ARYNNLAFGPVQGTGGSTAIANSWMQLRRAAAAAKEMLVAAAVFEWKVPASEVTVEKGVV
RHQKSNRSASFGEFATSASTLPVPQEPRLKKPEDWVYIGKRVPRIDSAEKTTGAAVYAQD
VRRPDRLIAVVAHAPMFGAKLRSFEAADAKAVAGVVDVVAIPTGVAVLARDTWSALKGRE
ALRVAWDDSLAEKRSSDAILAEYKQIAQRPGLVALNRGDARRAIAGASKVLEAEFEFPYL
AHAPMEPMNGTIARNPDGTIEAWAGFQFQTIEQATVAAILGVTPDRVKLNTLWAGGSFGR
RATTTADWIAEAAEILKASGARAPVHLVWTREDDMRGGYYRPMVYHNLRAGLDAAGEILG
WEHSIVGKSILIGSPFEAMMVKDGVDATTTEGVADTSYAIPNMRVEAHNAKEGTPVLWWR
SVGHSHTAQAMEVFIDEIAQAAGRDPVAYRMALLKDKPRDLGVLRLAAEKAGWGETLPGG
RGRGVSVHESFSTHVAMVSDVTVDGANVKVDRVVAAVDCGIPVNPDVIAAQVEGAVGFAL
SAVLRNRVTLKDGVVQEANFDTFEPTRMSEMPKVEVHIVPSAESPTGIGEPGVPNLAPSI
SNAVFAATGKRLRSLPLDLAALRGV
>A0A0N0RCH8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingopyxis sp. C-1|TrEMBL
MTRFSVNDRPVEYRMEPETPLLWALRDASNLTGTKYGCGTGECGACTVDIDGEAIRSCMV
TIAECEGRFVTTIEGLARDRSHAVQQAWVAEQVPQCGFCQSGMIMAAAALLRSNSNPSDA
EIDAAMTNICRCGTYPRIRTAIRLAGRVIRGEERIAAAPPPGIRPEDAAQAVPALRLPPG
S
>A0A7W5U9Q0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. BK612|TrEMBL
MNLQINNQSCQVDSEGDTPLLWIIRDELGMTGTKYGCGLAQCGACSVLVDGEVVRSCVTP
LDSVAGRQITTIEAIEADPVGKRVVAAWVKHQVPQCGYCQSGQVVAATALLKQTPNPSDD
EIAAAMINLCRCGTYNAIKEAVKDLSSKQGETL
>A0A0P1GEF9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tropicibacter naphthalenivorans|TrEMBL
MASIGKIARRTFLFGAVAVVGGAAFGTYVVTKPAPNPLNPQDGALNAFVVINGDGITLIA
PRAEMGQGTQTTWAALIAEELDVTLDQVTILHGPPAQAYFNSALMSEALPNKGYDASAFE
HSLGEVMGQLGKVFSLQVTGGSTAMKDGFERMRHTGAAAREMLKSAAAKRLDVPARDLTT
KAGMVIAPDGTEIAYTDLAAEAVNEKPGKIHLRDRSEWTILGQTQPRFDIPGKSTGTAQF
AIDTRLPGMKFAAVRRAPTRAGMRSYDDFEARRAPGVDKVVDLGDGLAVIANNTWTAMKV
LESIPVEWEESTHPATTAEMFKAIEDSFLGEQDSQMRDDGDVNKVQNTVHAEYRAPFLAH
ATMEPMSTTAWFDGTKLRIWTGNQGPTFLRTACADVAGIDEADVEVNVTLMGGGFGRRGE
FDYAVIATKVAKAMPGTPINVVWSREEDMTHDFYRPAAIGRFSGAVENGKPVSIDAQIAS
PAVSAQALERWMGTAPGGPDRAIVDGSFNQPYGVPNYCVTGFATSVTPPVGFWRAVGTSF
NGFFHESFMDELAHAAGADPMQMRLDLTRDEWLPAFYCLEAVRDMCNWTGETPEGVGRGL
ALTYAFGTPVAMVIEVQDQDGAIRLTNAWIAADPGVALDPGNIEAQLTGAMVYGLSAAMG
EEITFANGAVEQLNFPDYEPLRMSQMPNTQVTILENQERIGGIGEVATPPAAPALANALF
DLTGQRVRELPLNKVFTFAI
>A0A0P1GHQ5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Tropicibacter naphthalenivorans|TrEMBL
MELTVNGQTHTVDVDEDTPLLWVIREELGLTGTKYGCGIAQCGACTVLVDGVATRSCVTP
ASVVAGQDIKTIETVEETDVGKRVVEAWVENQVPQCGYCQSGQVLAATALLSETAQPSDE
DIEYAMTNLCRCGTYNKIRAAVRQASEA
>A0A7U3ZHD5|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)|TrEMBL
MATEDKQPKKKFSRRKFLQRGAIIFGGTVVATIAAKGHIRRFMAQKAEELDIPSVLSTYE
PHFWFEVLPDNTVVYKSTKLEMGQGIFTGLAMLAAEELEVSLEQIKVVHANTANGVEDSL
GTGGSNTTSSLFKPVREVAATLREMLKTEAARQWGVPITSVKVANGIMTSGTHKATYYDI
SVSTKEWEVPKTPALKPTAAFRFVGKDVKRIDLPPKVMGNPIFGIDQHLPDMLYAVMLQS
PYIGGTLKSINAGAAAKINGVVQVIEDGELVAVVAKNRYAAEKGLQALEAVWDIPKKWQQ
AEFEALTTVGIGTEVRIQSEGSPESILEETPNEVFRQEYRTPLATHAHMEPHGAVAQVEK
DKATLFVGTQASTVFRTAIAKAIDLKTEQVNIETTFAGGSFGRRMDAKHSEKAARIAQIV
GKPVHVFNTRQQEFQNAIYRPQTHHVLAAKFTKNGSIEAITHHQATADQILGGLPSNLGY
TLLGADFVSAGHGASILYNITHKSATLWQNKLPVQTGIWRSVGMLPNTFAIESFMNELAH
KTGKDPIRMRMELLSGTEPINRRYQKVLETLAEKSGWNQPKAAGIGRGMAIGNDRKSIAA
AVIEVMVVDNKIQVKKVTQVLDAGLAINPEGIRQQVEGATMMGITAALYEGLTVKDGQIA
ATNFHEYPMATLADTPEIETFIVEGHDEPYGVGEPPLAPVAPAIAAAIFDLTGKHLRTLP
LKLS
>A0A2N7RTG1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Janthinobacterium sp. AD80|TrEMBL
MRIEWLNQEALQHGGVTLGAALASAPVAVVGAADGVSRRGFMKAGAVAGGGLMLGFFLPG
AGKLAQAADAAPAKPVYAPNAFLHIAPDNTVTVQVNRLEFGQGVQTSLPMLIAEELDADW
SLVHGALAPAGEQYKDAAYGMQMTGGSGSIAHSFTQYREIGAKARAMLVGAAAAQWKVNP
DQVRAAKGVLYGPGGQKATYGEFADAAMRQSVPATVKLKDPRDFSIIGKPVKRLDAAAKS
TGKQQFSIDFKPPGAKVAMVARPPVFGAKVAKFDASKAKAIPGVLDVLEVKTDRGGSGVA
VIATGYWPAKQGRDALVIEWDSSAVEKVSSDKQLAAFKALAKTPGTVARPFDVAALAKAP
KKIDAVYEFPYLAHAPMEPLNCVIDLQVDKCTMWVGSQFQTGDQAAIAATSGLKPEQVTL
HTMMAGGGFGRRAVPSSDYVVEAVNVAKAYRAAGKSGPLKLMWSREDDIKGGYYRPSHVH
RAQIGLDAKGKIVAWDHMIVGQSIMAGTPFEAFMVKNGVDGTMVEGMGEPYTLPMKLSVH
TAKANVPVLWWRSVGSTHTAFVMETLIDEAAHVAKMDPVAYRKQLIDAKHTRHIAALDLA
VAKSGYGKKKLPKGQAWGVAMHESFNSVVAYVVTASVVEGAPKLHQVWAGVHCNLAVNPL
TIEAQVQGAALMALGMTIPGAAITLKDGVVEQQNFGDYPVPRMPDMPVIEVHLVPSGDAP
TGMGEPGVPPLAPAFANALFALTGKRLRKLPFDLAAA
>A0A2X1GM76|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Burkholderia cepacia|TrEMBL
MITLTVNGSEQHFDGNPDMPLLWYLRDVLGHTGTKFGCGMALCGACTVHVDGVAIRSCIT
PVAAASGKRVTTIEGLSTDLTHPLQQAWQELNVAQCGYCQSGQIMQAASLLKTNPHPTDA
DIDDAMSGNICRCGTYTRIRAAIRLAVSRGGAA
>A0A1Q8KHK7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudonocardia sp. Ae707_Ps1|TrEMBL
MPAHSAPAPERPTPGGSRKNVSRRRFLGYLVAAPTLVVAAEMGRQAVFNGAPQANAAAIP
SPPLPAELYDLLDALRDAARPTANLIKIEVNRDGTVSFAMPRSDNGQGIITSTQMIIAEE
MDLDPDQVIVTLADARPELVFNQLTAGSSTTFTTFAAFRVAAALAKGRLLDAAAAELGQD
KAVLTSRTGLILGQNGEELPFGELTEAAASPVNEAVEVILKPREEFTVIGKPRTKSDARA
MVTGKKQFATDLAIPDALPTVICRGPNLNSAPQGANNIDEVRNMPGVTDVEEMTTGVAVR
AKTFGQAIDGVNALDVNWDGGTVEGESDQTVLDQLRRAELPLAVPQVPGDTLEGDFTFYF
RSNSSLETNCAIADVRGDTAEIWGPAKNPIAAQAEIAKKLGIPQNSVTFHVTEGGGSFGR
KLFSDAAEEAAEVSQLMGKPVKLMWTRSDDSRQGRTHPMATCRVRAQVSGEAVSSFEIRH
TSVATEGNPGLGEAVTAAAQKAPGGNYTVSQALYITTQTNPYNVGVATSLLNEIDMRFNT
SSMRNIYSPDTATARELMIDQVAAKMGKDPYEFRSAYTKLERYKKVLDRAAEEADWGKSM
ADGTAQGIAMHVEYKGVAVAVVELDCRPETVNREIRSARTGPRVTKVTYVVDPGLIINPR
GYEAQMMGGINDGIAMTLTSGLHLEDGHFIEASWDNYFYTRQWNTPPEMNIVLIEDSEAP
EPGGAGEFGVAATCGAIACAYARATGEVPTQFPILHNEPLPFEPYPTIPPVPPSPTDGRE
LAR
>A0A0S4HMQ7|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MLTLNINGKDQALDVPADMPLLWVLRDVAHLTGTKFGCGMAQCGACTVHVDGAPLRSCIT
PATAVANGQKILTIEGLSTDGSHPVQQAWAELDVVQCGYCQSGQIMSAAALLAKIPKPTD
SDIDQALSGNICRCGTYPRIRAAVKRAAEIG
>A0A5E7MKY1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHQLDVTEDMPLLWAIRDVAGYNGTKFGCGMGLCGACTIHIEGAPARSCIT
PIGSVVGQNVTTIENLHVDPVGQVVQQAWLDTAVAQCGFCQGGQIMSATALLKTLPNPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A0B7DDV0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MITLKLNGQDHSLDVTEDMPLLWAIRDIAGYNGTKFGCGMGLCGACTIHIDGLPARSCIT
PIGSVVGQNVTTIDNLHADPVGQVVQQAWLDSAVAQCGFCQGGQIMSATALLKTNPDPSD
EQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7V8V2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNSPVSRRGFLKGSAVLGGGLVVAFVVPGGHKFAYAAENEGKVFAPNAFLRIAADNSVTV
LLGHSEMGQGIWTGLTMLIAEELDADWSKIRVQHSPASAADYGMPAFGGMQITGGSTSTW
MEFDRYRLAGATARQMLVEAAAKRFEVAPSAIRTESGVVIAGDKRATYGELADAAGQLPV
PDPKSITFKEAKDWKVIGKPTKRLDTPEKITGRARFGMDVQFEGLMTAMVARAPVFGATV
KSFEGAAALAIPGVHKVLQVPSGVAVVAEHFWAAKLGRDALKVDWDLGSLADMSSEKLLE
SFRKLAATPGTSATRAGDANTHFGKAAKKIDVEYSVPYLAHAPMEPLNCTVKISAGKCEI
WTGTQFQTLDQMVASKITGLKPEQVEIHTEFLGGGFGRRANPTSDFVAEAVQVAKAAAMP
VKTVWAREDDIRGGYYRSMYLHQARVGLGADGLPMSWQHVLVGQSIMAGTMLEATMVKNG
IDVTSVEGVADSPYIKDLAHHQVDLHSPKTGINVLWLRSVGHTHTGFVMESLIDELATAA
GKDPVEYRRTLLKAHPRHLGVLNLAVEKANWGAPLPDGHALGVAVHESFGSYVAQVAEVS
QDNLAIRVHRVVCAVDCGIAVNPQSIAAQMESCITFGLSMALHSKLTVKNGGVVQSNYHD
YQVLRLNEMPVVEVHIVPSSEKPGGIGEPGVPPTAPAVANAVFALTGQRLRELPLQLSGV
>A0A379I7S0|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MKKPNEVTVDMSRRRLLQGSGIALGGLVLSTWLPPLVAKSAAAEAAAAGRLGDRSSEGYG
AFVRVGPDGVVTVISPKIEMGQGAQTGIAMMVAEELEVPLDQVVIQEAPPNSALYTDSLM
QFQATGGSTSTRVTWEPLRRAGATARILLIQAAALQWRVAPSLCHAQNGQVFGPNGLQAA
YGDLVEAAATLPLPDAVPLKTPEQFKLLGTPAQRLDTPAKVNGKARFTIDLQIPGMLVAS
SITCPVYGGRLLNVDDTAARRVPGVRDIVRLDNAVAVTASNFWACQQAIKALKIEWDLGP
HAAIGSAQLDQELLAASSRDGVVAKRTGDIEQAKQQSASKFEAVYEQALLSHSPLEPMSC
VAHVRKDACELWVGTQVPVFAQQTAAQVTGLPVEKIQVHNQLIGGAFGRRLEFDFITQAV
AIARQVDYPIKLIWSREEDMTHDLYRPLYADRMQAALDEQGRPLGWEHRIAGASILARYV
GSLPPNGVDSDAVEVAVDPIYSLPHLQVRYIRQEPSVVPVSWWRGVGPLRGTYALECFID
ELAHNAKADPVAYRLELMAEQPRAQAVLRLLAEKCDWNQPLPAGQGRGVAVSAVFGSYVA
SLVELEMQGDLGVRIKRLVSVVDCGFATNPTSVKAQIEGGTLFGLSASLFNEILIENGQV
QQTNFHNYRQLRISEAPAVEVHLLPSLEAPGGVGEAGTALIGPALVNALFAASGQRIRRL
PLSRFGYYPV
>A0A0D0RZ45|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MELRINQKAYQVDAEADTPLLWVIRDNLGLTGTKYGCGLAQCGACSVLVDGNVVRSCVTP
VAGVVGREITTIEAIEEDEVGKRVVATWVERQVAQCGYCQSGQVMAATALLKHTPAPTAE
QINAAMINLCRCGTYNAIQSAMQDLAKQESV
>A0A5E7D7U9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNTLILNGQPYKMDVPDEMPLLWAIRDVAGGHPGTKFGCGMGLCGACTIHIDGQPARACI
TPLSSANGQNVTTIDELHNDPVGKIVQQAWLDTAVAQCGYCQGGQIMSATALLKANPNPS
DEQIEEAMVGNICRCGTYNRIKTAIRQASTHLKEAKA
>A0A5E7JTF2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MLNDIFSQELPRSLQHLLERDQADGAFTLPRRSFLKIVGIGGLALGAFPHLALAQEAAGG
DAALLKPSQQPSAFVQIDSSGQVTVTINRLEFGQGVQTGLPMILAEELDADWSLVRSRNG
NNNTAYQDPVFGMHLTGGSNSIKNSYTQYRELGARARAMLLAAAAARWNVEVTRLSTQAG
MVLGPAGLKASYGELAEAAMALPVPDKVTLKDPRDFRIIGQATTRIDAKAKSSGQQDFGI
DMHLPGQLTAVVARPPVFGAKIASLDDSAARAIKGVKAALRVPLDGGAEGVAVIADGYWQ
AKLGRDALKLQWDLATVEKVDSEQQLIQYRALAGQPGLVHFDADMAPLATAKHQLEAEFV
FPYLAHAPMEPLNCTVQISDKGAQLWVGTQFPGGDSAAAAKVLNLKPEHIQINVQTAGGG
FGRRGVPTSDFIVQACEVAKAARSVGLNVPIRTLWSREDDIKGGYYRPMHLHRARIGFDD
SGTVVAWDHVLIGQSILTDTMFGGQIKNGIDPTSTEGMRDPYPLPMRLTVHHPKLNVPVL
WWRSVGSTHTAFVMETLLDEIARTTKQDPVAYRMKLFGEQSPRHREALQLAVDQSGYGKR
QLPAGHAWGVAVHECFSSVVAYVVEASVQNGRPVLHHVTAGVHCNLVVNPRSVEAQVQGA
ALMGLSMCLPGNAITLKDGVVQQSNFADFSVPRITDMPEFAVHIVPSAEPPTGMGEPGLP
ALAPAFANAIASLTGKPIRELPFKLA
>A0A5E7M1K9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MNVRIDPSQQASVLDLHEPINVSRRRFLTGTAVGALVLGFGLPLGATRVQAAVAAATAER
GTQVPAFLEIRPDNRVRLLCPFMEGGQGTFTAMAQIVGEELDADPSTFLVEAAPPGEAYV
VLENGMRITGGSMSVRMSYPVMRRLGALARAMLLQAGAQQLGVPVSELSTEPGKVVHAKS
GRSLAYGELAERAMDLPVPDPASVKLRDPSQFRWIGKPVKRLDAYDKSTGKALYSIDLKV
DDMLHAAVQHAPRLGMTVGNLRNEEQVKAMKGVHSVHRLPGAVAVVAERWWHAKRAVEAI
QVDWQEPTAESKVRPMPADFSSDAWFKRLAEDKGPAKDDEHEGDVAAILKETKTRIDATY
HNQYLNHGQLEPPSALARFNPDGSLEVWLPNQAPDMFRADIAKRTGLDPSRITLHSPLLG
GFFGRHFLYDSASPYPQAIALSKAVGRPVKLIWSREEEFLRDVLRPVAAVNFRAALDNDG
WPLAIEAISATEGPTEALAGKQGEKLDPTALEGLSGKSYAIPNKRIAQIYAKGPAMLGYW
RSVGNSLNDFFYESFLDELADKGGKDPFDLRLHLLRDNKRLTTLLQAVGELSGGWKRGPF
TAEDGSKRARGVAMASPFGTETAVIAEVSIENGQVKVHDIWQAIDPGSIVNPAIVEAQVN
GAVALGLSQTLVEEAVWIDGKPRARNYDLYPILPPARMARVHVRVVESGEKMGGIGEPPL
PAVAPAVANAVATLTGQRVRSLPMSRHTFT
>A0A5E6SJU1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas fluorescens|TrEMBL
MSRLPNDFALSNLSRRGFLKGVGATGALVVAASWGWQDAFAEEKEKKFGADGMPHGWVDD
PKVYVSIAADGTVTVICNRSEMGQGVRTSLTMVVADELEADWAMVKVQQAPGDEVRFGNQ
DTDGSRSMRHWYEPMRRCGAAARAMLEQAAADQWKVSVGECQAQLHKVIHKPSGRELGYG
VLAAAAGALAVPARESLRLKQPSEFRYIGKEGTKAIDGEDIVNGRAVYGADVHFDGMLYA
TIARPTVYGGKVKSFDGSAAMKVPGVVKVVQIESRPLPSEFQPLGGIAVVASNTWAAIKG
REALKIEWDDGPNASYDSIAYRKELEAASLKPGKVVRNTGNLDEAMASADSTLEASYYLP
HLSQSPMEPMVAIARFKDGACQAWGPSQAPQVTRERIGERLGLPFDKVTFNVTLLGGGFG
RKSKPDFIIEAAILAKEFPGKAVRVQWTREDDIHCSYFHTVSAEYLKASLNKDGLPSGWL
HRTVAPSITALFAPGMNHEAAFELGMGFTNMAYAIPNIRLENPEATVHTRVGWYRSVSNI
PHGFAIQSFIDELAHKAGQDPLKYQIRLLGPDRQIDPRTLSEEWNYGESPERYPIDTARL
RTVLETAAKAAGWGRELPKGRGLGLAVHYSFVTYVAAVIEVEVKDDGTLVVHKADIAVDC
GPQINPERIRAQFEGACVMGLGNAVLGEISFKDGKVQQDNFHMYEVARMSLAPKEVAVHL
VTPPGNVPLGGVGEPGVPPIAPALCNAIFAATGKRIRNLPVRYQLSGWQKAGA
>A4YKG9|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MNGRDHEVAVEADTPLLWVLRDTLGLTGTKYGCGIAQCGACTVMIDGQATRSCQVPIESI
GSAEIRTIEAIEQDATGRKVVEAWVADQVPQCGYCQSGQVMAATALLTQNPKPSDSDIAD
AMTNLCRCGTYNRIAAAIRRAAQA
>A4YQR2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Bradyrhizobium sp. (strain ORS 278)|TrEMBL
MTPRLNRRSFVIGTAALGGGLALGLDIPFGGPQVVRAADGSPEVNAWVVIRPDDTVVIRI
ARSEMGQGSLTGLAQLVAEELACDWSKVTTEYPTPGQNVARKRVWGDFSTGGSRGIRSSQ
DYVRKGGAAARMMLIQAAADEWKVPVAECTAANSVITHKASGKTTTYGKVAEAAAKLSPP
ADVKLKDPKDWTLIGKGVKRLDTADKVTGAMIYGADIKLPGMLNAAIKDCPVTGGKLKSY
DEAKIAGMKGVKKVVAVDGTAVAVVADTWWHAKTALDALPIVWDEGPNAKVSSESIGKWL
AEGLDSGPAFVGNENGDAKAALAGAVKKVEAVYNYPYQNHATMEPMNATALYTPERCEVW
CGTQNGEAAFAAVLEASGLPADKCEVHKLILGGGFGRRGQTDYVRQAVQIAKAMPGTPVK
LLWSREEDMTHGRYHPITQCKLTGGFDADNNLTALHMRISGQSILFSLRPDALVNGKDPA
TFQGLAPSGEATIGYSVPNLLIEHSMRNPHINPGFWRGVNVNQNAIYLECFMDELANAVG
QDPLEFRRKLMAKNPKHLAVLNAVAEKIGWGTPAPEGVHRGLAQLHGYGSYVAGAAEISV
IDGSKIKVHRIVASTDPGYVVNPAQVERQIAGSFVYGLSALFYGGCTVKDGRIEQTNFDS
YNSMRIAEMPKVEAIMVPSGGFWGGVGEPTIGVAAPAVLNAFFAATGKRIRSVPLRDQNI
TFA
>A0A7W9APS3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas yantingensis|TrEMBL
MTRLTVNNQPIQYALSPETPLAVALRDASNLTGTKIACSNGECGACTVDIDGRAVRSCAV
TIASVEGSFVTTIEGLARDRDHPVQQAFLAGNVSQCGYCIPGLVMAAAVLIREVRDPDEA
AIRRAMSHHCRCGIQPRLVEAVRRAAAIERGDETVAPVASPDIDARDAAKDVPALAAPKR
LPRS
>A0A3G7WZJ1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudomonas orientalis|TrEMBL
MSTVLPDVTLDAPINLSRRRFLASTAVGALVIGFGLPLGASRVQAATGAIGERGTQVPAF
LEIRPDGSVRLLSPFMEGGQGTHTAMAQIIGEELDADPATFSVEAAPPGEAYVVMENGMR
ITGGSMSVRMSYPTMRRLGALARAMLLQAAAEQLGVPVAQLTTQPGRVVHAASGRSLGYG
ELAGRALDMPVPDPAGITLRDPSQFRWIGKPVKRLDAYDKSTGKAQYCIDLKVDGMLHAA
VQHAPRLGMTVGSLRNQAQVEAMKGVHSVHTLPGAVAVVAERWWHAKRAVEAIQVDWLEA
AADSSVRAMPADFSSDKYRDFLATQEGPARDEENAGDVAATLASAKTRVDATYHNQYLNH
AQLEPPSALARYNPDGTLEVWLPNQAPDMFRADIAKRTGQAIEQITLHSPLLGGFFGRHF
LYDSANPYPQAIALTKAVGRPIKLIWSREEEFVRDVLRPVAVVKFRAALDDKGLPLAIEA
VSATEGPTEAIAGKQGDKLDPTALEGLSGKSYAIPNKRIAQIYVKGPAMLGYWRSVGNSL
NDFFYEAFLDELADKGGHDPYELRLHLLRDNARLTTLLQAVGELSGGWKRGPFTAEDGSR
RARGVAMASPFGSHAAVIAEVSIEKGQVKVHDIWQAIDPGSIVNPAIIEAQVNGAVALGL
SQTLLEEAVYVDGMPRARNYDLYPILPPSRMARVHVKIVESGEKMGGIGEPPLPAVAPAV
ANAVAQLTGQRIRSLPLSRYTFS
>A0A654DMJ3|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Sphingomonas sp. T1|TrEMBL
MTRFTVNNQAIEYRLDPATPLLWALRDASNLTGTKYGCGTGHCGACTVDIDGRAVRSCRV
PIGSIEGRYVTTIEGLSHERNHPLQLAFIAEAVPQCGFCIPGMIMAAAALLKRDADPSEA
LIREQITNLCRCGVYPRVVEAIQRAGRATRGEEVLPAGPRPGIDPADSARLVPALVPPPA
R
>A0A6N4WZG2|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Lentimonas sp. CC11|TrEMBL
MDLELNINGTVHALKDADPNMPLLWALRDTLGLTGTKYGCGIAQCGACTVHLNGAPIRAC
SLPLAAAADGEITTIEGLSEDGSHPVQQAWIEEDVPQCGYCQAGQIMSAVALLQQNPKPN
YNDIDQFMAGNLCRCGTYPRIRKAIQSAAQKLAQ
>A0A165MYK8|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Pseudovibrio sp. W74|TrEMBL
MYPKIPLTVNGQKQEIEADPEMPLLWALRDIMDIKGPKFGCGIAACGACTVLIDGEAVRS
CSQPVGEVEGEITTIEGISQGDELHAVQQAWMKHSVPQCGYCQSGQIMAAVALLEENPDP
TDEDISDAMTNLCRCGTYPKIKAAIKDAAQTLGA
>A0A7Y9WU81|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MIEIVVNDTRHSLDNVPEDMPLLWVLRDRLKLTGTKFGCGGGFCGACTVHLEGEAVRSCL
LPAVAVAGKNITTIEGLSKDGRHPLQLAWVAEDVPQCGYCQSGQLMQAAAFLKDKPTVND
ETISTAMSGNICRCGTYSRIRKAIKRAASGDPALAEVVMPACIAACASHASAEEV
>A0A7Y9WT15|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Paraburkholderia bryophila|TrEMBL
MLKRRTFLLGGASAVGALLVGWSVLPPGQRLTTSTPLPAEGTQVPLNGWVKIAADNSVTI
IMCKAEMGQGIHTGLAMLLAEELDAEWSQVRVEDSPIDRIYNSVQNIVDDLPFRPDDDSA
VKRATVWMTRKLVRDAGTMMTGGSSSINDLWTPMREAGASARAMLIGAAAAQWQVPAAEC
RAESGEVLHPSGHRASFGELSSLAAQQPLPRNVALKDPANFKLIGKPVRRIEAASKINGT
ARFGIDALPDGLLYASVVMCPTLGGTAAHFDAGPAEKLPGFIKAFAVAPYNGGTGGVAVI
ADNPFRAMNAVTAVTVDWNDGDAAHISSADVQSRLMQALDDSDGHAYYRLGDVDAALSGA
TRTVSADYHAPYLAHGAVEPLNCTVQVADGVATVWVSTQVPALARHHVAKVLNLDADKVD
VQTQLLGGAFGRRLELDFIAQAAVIARQGGGRPVQTIWSRAQDFTHDFYRPACVSRLKAG
LDAHGKLVAWDSLSAGQAIVPESLARYYGVPRLPIDKTTCEGAFDQPYEWPAARVAHKIV
DLPIPIGFWRSVGHSHQAFFTESFTDELAAAAGRDPIAFRAELLARHPRHLAVLKRVAAL
SEWGRPLSHAADGAPRSRGVALHEAFGSVVAQVAEVSLGPGKQIRVHRVVCVIDCGLPVN
PNLIRQQMESGIVFGLSTALQDEITIVDGQVQQKNFVDFPVVRMNDCPAIETEIMPSQLH
PQGVGEPGVPPVAPAVANAVFALTGQRLRALPLKLA
>W6WGK1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Rhizobium sp. (strain CF080)|TrEMBL
MTIQDINTTRRGFIAGSGLVIGVAIAPKMLSAAPTGVHAGGDPALAPMNAFVKIGTDDTV
TVLSKHIEFGQGPFTGLATLVAEELDADWSQMRAVHSPTDNKVYANLMFGLQGTGGSSSI
ANAYEQMRKAGATARAMLVVAAANEWKVPASQITVQKGRIKHAASGKESGFGAFAEKAAR
LTPPAEPKLKDPKDFVLIGTDLPKLDTHGKTNGTAIFTLDITPNNLLIAVVAHPEHFGAT
VKSFNDAEARKVQGVVDVKQVPSGIAVYADNTFAALKGRDALSIEWDLSKAETRSSEELS
ADYRKLFGEKGLEATNNGNVDNAFKAPGLQTVEAEIVFPFLAHAPMEPLDAVFIKADDGS
VDIYNGAQFPGMDQEVAAKILGLDQSKVRVNTQLAGGSFGRKAQFGSPYIQEAAAVYAAT
DRSRPLKHMWTREDDIRGGYYRPMYAHRMRGAINAQGQITAWEQVIVGQSIMGKADLDPT
SVEGASNLPYTIPNLKVSAHNVQLAIPPLWWRSVGHTHTGFAVETFVDELFQKIGKDPVE
GRLALLGEKPRHAGVLKKAAEMANWGSPVPEGRARGVAVVESFGTFVGQVVEVSVGPEGA
PRVHKVWVAVDCGVAVNPNVIKAQMEGGVGYGLGAVLFDAVTLAKGGKIVQSNFHDYRSI
RINEMPDVAVEIIKSSEKPSGVGEPGVPPVGPAVANAWRHLTGAPVRQLPIVNIVSA
>A0A7W7EUV1|Isoquinoline 1-oxidoreductase|EC 1.3.99.16|Novosphingobium taihuense|TrEMBL
MARLTVNNQPVQYRLEDDTPLLWALRDAANLTGTKYGCGTGECGACMVIVDGQAMPSCTL
SLGEAEGRNVTTIEGLSGDRSHPVQQALVAEQAIQCGFCTPGIVMAAAALLTTNASPTDE
DIARAITNICRCGVYPRLTRAIQRAARVMRGEETISAAPPPAIVAPGAG