>Q6U6H1|thyroxine 5'-deiodinase|EC 1.21.99.4|Halocynthia roretzi|Swiss-Prot
MHNLLEIKIIRFLRNVFYFLHVLFNECLDTLKAYYKRWRGMKSEKPLDPSSRRARIIQAT
GVDLSRDPAMQSLRGVYHMAKSILYADVLRTAVRGGNAPNSSLVNYRTKEKCNILDFMKP
GRPLVVNFGSCSUPPFMASFEIFSRIIDSYHERADFLTVYIEEAHSSDLWALKNNKYSIP
SHITFEDRMEAAAIFKKSVSFECAFAVDTMKDETNLSYGALPERTAIILDGKVQYIGGIG
PFNYDLVELEKELIAVLKK
>P49894|thyroxine 5'-deiodinase|EC 1.21.99.4|Canis lupus familiaris|Swiss-Prot
MGLPRPVLWLRRLWVLLQVAVQVAVGKVFLKLFPARVKQHIVAMNGKNPHFSYDNWAPTL
YSMQYFWFVLKVQWQRLEDRTEPGGLAPNCPVVRLSGQRCNIWDFMQGNRPLVLNFGSCT
UPSFLFKFDQFKRLIEDFCSTADFLIIYIEEAHASDGWAFKNNVNIRTHQTLQDRLQAAR
LLLDRAPPCPVVVDTMRNQSSQFYAALPERLFVLQEGRILYKGKPGPWNYHPEEVRAVLE
KLHS
>O42411|thyroxine 5'-deiodinase|EC 1.21.99.4|Gallus gallus|Swiss-Prot
LSIRVLLHKLLILLQVTLSVVVGKTMMILFPDTTKRYILKLGEKSRMNQNPKFSYENWGP
TFFSFQYLLFVLKVKWRRLEDEAHEGRPAPNTPVVALNGEMQHLFSFMRDNRPLILNFGS
CTUPSFMLKFDEFNKLVKDFSSIADFLIIYIEEAHAVDGWAFRNNVVIKNHRSLEDRKTA
AQFLQQKNPLCPVVLDTMENLSSSKYAALPERLYILQAGNVIYKGGVGPWNYHPQEIRAV
LEKLK
>Q6V915|thyroxine 5'-deiodinase|EC 1.21.99.4|Felis catus|Swiss-Prot
MGLSQLGLWLRRLWVLFQVALQVAVGKVFLILFPSRVKQHIVAMNRKNPHFSYDNWAPTL
YSVQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVRLSGQRCSIWDFMKGNRPLVLNFGSCT
UPSFLFKFDQFKRLIEDFCSIADFLIIYIEEAHASDGWAFKNNVNIRNHRNLQDRLQAAC
LLLDRSPRCPVVVDTMKNQSSRLYAALPERLYVLQAGRILYKGKPGPWNYHPEEVRAVLE
KLHS
>Q804E1|thyroxine 5'-deiodinase|EC 1.21.99.4|Fundulus heteroclitus|Swiss-Prot
MFLQKLLVYLTAACMFCYILVLSATLNVLKVLSPNLARKLILKMGEKVTMTQNPKFSYED
WGLTYGSLAFIKVASQTMWLSLGQEAFVGEDAPDSPVVTVDGERTSICNYLKGNRPLVLS
FGSCTUPPFMFKLGEFKQLVRDFVDVADFLVVYVAEAHSTDGWSFGNNFDIRQHRSLEDR
LSAARILVQNDPLCPVVVDEMSNVSAIKYAAQPERLYVLQAGKVLYKGAMGPWGYNPQEV
RSVLQKMR
>P49895|thyroxine 5'-deiodinase|EC 1.21.99.4|Homo sapiens|Swiss-Prot
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
RAVLEKLHS
>Q61153|thyroxine 5'-deiodinase|EC 1.21.99.4|Mus musculus|Swiss-Prot
MGLPQLWLWLKRLVIFLQVALEVAVGKVLMTLFPGRVKQSILAMGQKTGMARNPRFAPDN
WVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSGQKCNIWDFIQGSRPLVLN
FGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNNVDIRQHRSLQER
VRAARLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKAGPWNYNPEEV
RAVLEKLCTPPRHVPQL
>O42449|thyroxine 5'-deiodinase|EC 1.21.99.4|Oreochromis niloticus|Swiss-Prot
MFLQKIVLYLSTACMFCYMLGKFLMLVILQFFSPSLAKKFILRMGEKITMTQNPRFNYED
WGLTFMSLAFIKTASSHMWLSLGEEAFVGGEAPDSPVVTMDREKTSISKYLKGNRPLVLS
FGSCTUPPFMYKLDEFKQLVKDFSDVADFLVIYIAEAHSTDGWAFKNNYDINQHQSLEDR
LSAAQVLVQSEPLCPVVVDEMTDVTTIKYGALPERLFILQAGKVLYKGGKGPWGYNPAEV
RSFLEKIK
>Q6QN13|thyroxine 5'-deiodinase|EC 1.21.99.4|Sus scrofa|Swiss-Prot
MELPLPGLWLKRLWVLFQVALHVAMGKVLMTLFPGRVKQDILAMSQKTGMAKNPHFSHEN
WIPTFFSAQYFWFVLKVRWQRLEDKTEEGGLAPNCPVVSLSGQRCHIWDFMQGNRPLVLN
FGSCTUPSFIFKFDQFKRLIEDFSSIADFLIIYIEEAHASDGWAFKNNVDIKNHQNLQDR
LRAAHLLLDRSPQCPVVVDTMKNQSSRLYAALPERLYVLQAGRILYKGKPGPWNYHPEEV
RAVLEKLHS
>A4GT88|thyroxine 5'-deiodinase|EC 1.21.99.4|Oryctolagus cuniculus|Swiss-Prot
MGLPRPGLWLKRLWVLVQVAVEVAVGKVLMTLFPERVKQNILAMGQKTGIAQNPNFAQDS
WIPTFFSTQYFWFVLKVRWQRLEDATEPGGLAPNCSVVRLSGQQCSVWDFMRGNRPLVLN
FGSCTUPSFLSKFDQFKRLIQDFSSIADFLIIYIEEAHASDGWAFKNNVDIKNHRNLQDR
LRAASLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVLRQGRILYKGESGPWNYNPEEV
RAVLEELHS
>P24389|thyroxine 5'-deiodinase|EC 1.21.99.4|Rattus norvegicus|Swiss-Prot
MGLSQLWLWLKRLVIFLQVALEVATGKVLMTLFPERVKQNILAMGQKTGMTRNPRFAPDN
WVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSGQKCNVWDFIQGSRPLVLN
FGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNNVDIRQHRSLQDR
LRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKPGPWNYNPEEV
RAVLEKLCIPPGHMPQF
>Q95N00|thyroxine 5'-deiodinase|EC 1.21.99.4|Suncus murinus|Swiss-Prot
MGLPGLGLLLKRFGVLVRVALKVAVGKVLLTLWPSAIRPHLLAMSEKTGMAKNPRFTYED
WAPTFFSTQYFWFVLKVNWQQLEDRTKQGDIAPDSPVVHLSGQRARLWDFMQGNRPLVLN
FGSCSUPSFLFKFDQFKRLVEDFSSVADFLTVYIEEAHASDGWAFKNNVDIRRHRDLQER
LQAARLLLDRNPGCPVVVDTMENRSSQLYAALPERLYVLQEGRILYKGGPGPWNYHPEEV
HAVLEQLCRSSAQSPRL
>Q2QEI3|thyroxine 5'-deiodinase|EC 1.21.99.4|Xenopus laevis|Swiss-Prot
MESLLQTIKLMLRYIQKALILFFLFLYVVVGKVLMFLFPQTMASVLKSRFEISGVHDPKF
QYEDWGPTFFTYKFLRSVLEIMWMRLEDEAFVGHSAPNTPVVDLSGELHHIWDYLQGTRP
LVLSFGSCTUPPFLFRLGEFNKLVNEFNSIADFLIIYIDEAHAADEWALKNNLHIKKHRS
LQDRLAAAKRLMEESPSCPVVLDTMSNLCSAKYAALPERLYILQEGKIIYKGKMGPWGYK
PEEVCSVLEKKK
>Q5I3B2|thyroxine 5'-deiodinase|EC 1.21.99.4|Bos taurus|Swiss-Prot
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGQWRRMLTSEGM
RCIWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTECHLLDFASP
ERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLFF
EVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAY
LGGKGPFFYNLQEVRRWLEKNFSKRUKLD
>Q9IAX2|thyroxine 5'-deiodinase|EC 1.21.99.4|Gallus gallus|Swiss-Prot
MGLLSADLLITLQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEGL
RCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKGNDGSNSSWKSVGGKCGTKCHLLDFANSE
RPLVVNFGSATUPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDGWAAPGISPSSFE
VKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFERVCIVQRQKIAYL
GGKGPFFYNLQEVRLWLEQNFSKRUNPLSTEDLSTDVSL
>P79747|thyroxine 5'-deiodinase|EC 1.21.99.4|Fundulus heteroclitus|Swiss-Prot
MGSASEDLLVTLQILPGFFSNCLFLALYDSVVLVKRVVALLSRSRSAGCGEWRRMLTSEG
LRSIWNSFLLDAHKQVKLGCEAPNSKVVKVPDGPRWSSTVVPCGSRIQTGGECRLLDFES
SDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAPQMGACS
FSFRKHQNLEERIGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVANERVCIVHQRKIA
YLGGKGPFFYSLKDVRQWLELSYGRR
>Q92813|thyroxine 5'-deiodinase|EC 1.21.99.4|Homo sapiens|Swiss-Prot
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
>P49896|thyroxine 5'-deiodinase|EC 1.21.99.4|Lithobates catesbeianus|Swiss-Prot
MGLLSVDLLITLQILPGFFSNCLFLALYDSVVLVKHVLLQLNRSKSSHGQWRRMLTPEGL
RCVWNSFLLDAYKQVKLGGDAPNSNVIHVTDKNSSSGKPGTPCHLLDFASSERPLVVNFG
SATUPPFISQLPAFSKMVEEFSAVADFLLVYIDEAHPSDGWAAPGISSYEVKKHRNQEDR
CAAANKLLEQYSLPPQCQVVADCMDNNTNAAYGVSFERVCIVQRQKIVYLGGKGPFFYNL
QEVRQWLELTFGKKAESGQTGTEK
>Q9Z1Y9|thyroxine 5'-deiodinase|EC 1.21.99.4|Mus musculus|Swiss-Prot
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGL
RCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERP
LVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVK
KHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGG
KGPFSYNLQEVRSWLEKNFSKRUILD
>Q8UVX8|thyroxine 5'-deiodinase|EC 1.21.99.4|Neoceratodus forsteri|Swiss-Prot
MGLLSVDLLITLQILPWFFSNCLFLALYDSVVLLKHVILLLSCSKSSRGEWRRMLTSEGL
RTVWNSFLLDAYKQVKLGGDAPNSKVVRVTSGCCRRRSFSGKGESECHLLDFASSNRPLV
VNFGSATUPPFISQLPTFRKLVEEFSDVADFLLVYIDEAHPADGWAAPGVATKSFEVKKH
RSQEERCVAAHKLLEHFSLPPQCQVVADCMDNNTNVAYGVSFERVCIVQRQKIAYLGGKG
PFFYNLKEVRHWLEQTYRKRUVPTCELIM
>L7WGA7|thyroxine 5'-deiodinase|EC 1.21.99.4|Petromyzon marinus|Swiss-Prot
MPHVNLLVVLLILPGVFSNCLFLALYDAVSFLRRALQASLTHSAKGDAQHPRMLTAQGML
SVWRSYVLDAHKKVRLGGKAPNSSVVALGGHSSSSPSFSCAASSSSSHETPTPRTTAEAA
ATVTTSTTTTSTTSSTAACRLLDFARAHRPLVVNFGSASUPPFVEQLGEFCDLVRDFAGV
ADFLVVYIEEAHPSDAWPAPGGLEVPRHLALGDRCVAASQLRGLMPPLGRCPVVADAMDN
NANIDYGVSYERLYVIQDGRIRYLGGKGPFFYRVREVKSFLESVKASR
>Q6QN12|thyroxine 5'-deiodinase|EC 1.21.99.4|Sus scrofa|Swiss-Prot
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGM
RCIWKSFLLDAYKQVKLGEDAPNSSVVHVSNPEGSNNHGHGTQEKTVDGAECHLLDFANP
ERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSF
EVKKHQNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAY
LGGKGPFYYNLQEVRRWLEKNFSKRUKKT
>P70551|thyroxine 5'-deiodinase|EC 1.21.99.4|Rattus norvegicus|Swiss-Prot
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGL
RCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGNNCASEKTADGAECHLLDFASAERP
LVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSMSFEVK
KHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGG
KGPFSYNLQEVRSWLEKNFSKRUILD
>A0A8N7V0B4|thyroxine 5'-deiodinase|EC 1.21.99.4|Danio rerio|TrEMBL
MGLLSVDLLVTLQILPGFFSNCLFFVLYDSIVLVKRVVSLLSCSGSTGEWQRMLTTAGVR
SIWNSFLLDAYKQVKLGEAAPNSKVVKVTGINRCWSISGKTHNQCHLLDFESPDRPLVVN
FGSATUPPFISQLPVFRRMVEEFSDVADFLLVYIDEAHPSDGWVGPPMENFSFEVRKHRN
LEERMFAARTLLEHFSLPPQCQLVADCMDNNANIAYGVSYERVCIVQKNKIAYLGGKGPF
FYNLKDVRRWLEKCYGKU
>A0A8M1P8S9|thyroxine 5'-deiodinase|EC 1.21.99.4|Danio rerio|TrEMBL
MGSAVGFALRKLFVYISAVLMVCAAILRMSMLKLLSFISPGRMRKIHMKMGERTTMTQNP
KFRYEDWGPAFFSLAFIKTLFFVNWCSLGLEAFEGHSAPDSALITLDRQKTSVHRFLKGN
RPLVLSFGSCTUPPFLYKLDEFKQLVKDFSNVADFLIVYLAEAHATDAWAFKNNVDISVH
KNLEERLAAARTLLKEDPPCPVVVDEMNNITASKYGALPERLYVIQSGKVIYQASDLGGT
SLKRFEKFWKKVNKWRRMAKCFLS
>A0A8M1N345|thyroxine 5'-deiodinase|EC 1.21.99.4|Danio rerio|TrEMBL
MGSAVGFALRKLFVYISAVLMVCAAILRMSMLKLLSFISPGRMRKIHMKMGERTTMTQNP
KFRYEDWGPAFFSLAFIKTLFFVNWCSLGLEAFEGHSAPDSALITLDRQKTSVHRFLKGN
RPLVLSFGSCTUPPFLYKLDEFKQLVKDFSNVADFLIVYLAEAHATDAWAFKNNVDISVH
KNLEERLAAARTLLKEDPPCPVVVDEMNNITASKYGALPERLYVIQSGKVIYQGGIGPWG
YKPEEVRKVLEKSK
>A0A0A0BCK2|thyroxine 5'-deiodinase|EC 1.21.99.4|Methylophaga thiooxydans|TrEMBL
MKSRHVPYRFEHFDIRVMFSDLRFSSVSKQFNSLNMKQRVKLSDGREQTLTILANGKPLI
FITGSLSCPMTVSVLPFLRQVKKDFDDKFNFILIYVREAHPGEHYQQARTWEEKQQHACQ
FLSIHDLDIPTIVDGLEGELHKQLDTKPNSLHIVDGNGSVLFQSLWSGDFVVVEQALNSI
ADGLTPPKRMSERMVSPFMRGAGYIHQTLKQAGKRAGRELMFGAPPIWLLSRTAASFTMI
TPAKRGTLAMGVLLMITAAITVILL
>H6U5U5|thyroxine 5'-deiodinase|EC 1.21.99.4|Azumapecten farreri|TrEMBL
MYCFNRKPFHPAHVVNIRTRCFDMFAIFDSSQFSFLLFLGEAMKKPDVLWSDEVPFIWIK
TFKSLFMVIVEIIIISVVVILSKLPFVRNLLQSQFKNRGVPGTEKLQANISAKTLTTRAR
VKLVDALFRKTILGRKAPNTDLYDMDTKSYKKLYSFQKAGRPLVLNFGSCSUPPFIAKVE
EMKTIIRDFADVADFLTIYIREAHPVEGWQVFGHRFEDMKDHKTLGDRVAAAKLLRDFDL
KCPILIDPMDNQNAVQYAAVPERLYILYDNTVMYFGAVGPENYKPHAIRSWLNSFRNEG
>Q9C0K2|thyroxine 5'-deiodinase|EC 1.21.99.4|Homo sapiens|TrEMBL
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
RCVWKSFLLDAYKQ
>Q9Z148|thyroxine 5'-deiodinase|EC 1.21.99.4|Mus musculus|Swiss-Prot
MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGL
TGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSSLGDTPQSEETLPKANPDSLEPAG
PSSPASVTVTVGDEGADTPVGAASLIGDEPESLEGDGGRIVLGHATKSFPSSPSKGGACP
SRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKT
MSKPSNGQPPIPEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLNSGSLSEDLGSAGGSGD
IILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEE
EEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRA
KEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCS
CRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRAR
MVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVT
IPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSG
PSLTLPNGGCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVI
LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV
NNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWT
PIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAV
NYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKL
RLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRN
ITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSC
KNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLF
DLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTG
EELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPP
INT