Sequence of VGFR2_HUMAN
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MQSKVLLAVA LWLCVETRAA SVGLPSVSLD LPRLSIQKDI LTIKANTTLQ ITCRGQRDLD
60 WLWPNNQSGS EQRVEVTECS DGLFCKTLTI PKVIGNDTGA YKCFYRETDL ASVIYVYVQD
120 YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGSISNLNVS LCARYPEKRF VPDGNRISWD
180 SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YRIYDVVLSP SHGIELSVGE
240 KLVLNCTART ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS
300 DQGLYTCAAS SGLMTKKNST FVRVHEKPFV AFGSGMESLV EATVGERVRI PAKYLGYPPP
360 EIKWYKNGIP LESNHTIKAG HVLTIMEVSE RDTGNYTVIL TNPISKEKQS HVVSLVVYVP
420 PQIGEKSLIS PVDSYQYGTT QTLTCTVYAI PPPHHIHWYW QLEEECANEP SQAVSVTNPY
480 PCEEWRSVED FQGGNKIEVN KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKVGRGE
540 RVISFHVTRG PEITLQPDMQ PTEQESVSLW CTADRSTFEN LTWYKLGPQP LPIHVGELPT
600 PVCKNLDTLW KLNATMFSNS TNDILIMELK NASLQDQGDY VCLAQDRKTK KRHCVVRQLT
660 VLERVAPTIT GNLENQTTSI GESIEVSCTA SGNPPPQIMW FKDNETLVED SGIVLKDGNR
720 NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA FFIIEGAQEK TNLEIIILVG TAVIAMFFWL
780 LLVIILRTVK RANGGELKTG YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL
840 GRGAFGQVIE ADAFGIDKTA TCRTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN
900 LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRQGKD YVGAIPVDLK
960 RRLDSITSSQ SSASSGFVEE KSLSDVEEEE APEDLYKDFL TLEHLICYSF QVAKGMEFLA
1020 SRKCIHRDLA ARNILLSEKN VVKICDFGLA RDIYKDPDYV RKGDARLPLK WMAPETIFDR
1080 VYTIQSDVWS FGVLLWEIFS LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML
1140 DCWHGEPSQR PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS
1200 CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK VIPDDNQTDS
1260 GMVLASEELK TLEDRTKLSP SFGGMVPSKS RESVASEGSN QTSGYQSGYH SDDTDTTVYS
1320 SEEAELLKLI EIGVQTGSTA QILQPDSGTT LSSPPV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
499955
Jin P.,Zhang J.,Sumariwalla P.F.,Ni I.,Jorgensen B.,Crawford D.,Phillips S.,Feldmann M.,Shepard H.M.,Paleolog E.M.
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Arthritis Res. Ther.
10
0-0
2008
499956
Albuquerque R.J.,Hayashi T.,Cho W.G.,Kleinman M.E.,Dridi S.,Takeda A.,Baffi J.Z.,Yamada K.,Kaneko H.,Green M.G.,Chappell J.,Wilting J.,Weich H.A.,Yamagami S.,Amano S.,Mizuki N.,Alexander J.S.,Peterson M.L.,Brekken R.A.,Hirashima M.,Capoor S.,Usui T.,Ambati B.K.,Ambati J.
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.
Nat. Med.
15
1023-1030
2009
499959
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
499960
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
499961
Terman B.I.,Carrion M.E.,Kovacs E.,Rasmussen B.A.,Eddy R.L.,Shows T.B.
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
Oncogene
6
1677-1683
1991
499962
Patterson C.,Perrella M.A.,Hsieh C.-M.,Yoshizumi M.,Lee M.-E.,Harber E.
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
J. Biol. Chem.
270
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1995
499963
Terman B.I.,Dougher-Vermazen M.,Carrion M.E.,Dimitrov D.,Armellino D.C.,Gospodarowicz D.,Boehlen P.
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.
Biochem. Biophys. Res. Commun.
187
1579-1586
1992
499964
Waltenberger J.,Claesson-Welsh L.,Siegbahn A.,Shibuya M.,Heldin C.H.
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
J. Biol. Chem.
269
26988-26995
1994
499965
Takahashi T.,Shibuya M.
The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts.
Oncogene
14
2079-2089
1997
499966
Kroll J.,Waltenberger J.
VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR).
Biochem. Biophys. Res. Commun.
252
743-746
1998
499967
Gerber H.P.,McMurtrey A.,Kowalski J.,Yan M.,Keyt B.A.,Dixit V.,Ferrara N.
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.
J. Biol. Chem.
273
30336-30343
1998
499968
Kroll J.,Waltenberger J.
A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells.
Biochem. Biophys. Res. Commun.
265
636-639
1999
499969
Kendall R.L.,Rutledge R.Z.,Mao X.,Tebben A.J.,Hungate R.W.,Thomas K.A.
Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues.
J. Biol. Chem.
274
6453-6460
1999
499970
Dougher M.,Terman B.I.
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.
Oncogene
18
1619-1627
1999
499971
Mitola S.,Soldi R.,Zanon I.,Barra L.,Gutierrez M.I.,Berkhout B.,Giacca M.,Bussolino F.
Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.
J. Virol.
74
344-353
2000
499972
Takahashi T.,Yamaguchi S.,Chida K.,Shibuya M.
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.
EMBO J.
20
2768-2778
2001
499973
Duval M.,Bedard-Goulet S.,Delisle C.,Gratton J.P.
Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells.
J. Biol. Chem.
278
20091-20097
2003
499974
Dixelius J.,Makinen T.,Wirzenius M.,Karkkainen M.J.,Wernstedt C.,Alitalo K.,Claesson-Welsh L.
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
J. Biol. Chem.
278
40973-40979
2003
499975
Holmqvist K.,Cross M.J.,Rolny C.,Haegerkvist R.,Rahimi N.,Matsumoto T.,Claesson-Welsh L.,Welsh M.
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
J. Biol. Chem.
279
22267-22275
2004
499976
Fox S.B.,Turley H.,Cheale M.,Blazquez C.,Roberts H.,James N.,Cook N.,Harris A.,Gatter K.
Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus.
J. Pathol.
202
313-320
2004
499977
Jia H.,Bagherzadeh A.,Bicknell R.,Duchen M.R.,Liu D.,Zachary I.
Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells.
J. Biol. Chem.
279
36148-36157
2004
499978
Matsumoto T.,Bohman S.,Dixelius J.,Berge T.,Dimberg A.,Magnusson P.,Wang L.,Wikner C.,Qi J.H.,Wernstedt C.,Wu J.,Bruheim S.,Mugishima H.,Mukhopadhyay D.,Spurkland A.,Claesson-Welsh L.
VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.
EMBO J.
24
2342-2353
2005
499979
Lamalice L.,Houle F.,Huot J.
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.
J. Biol. Chem.
281
34009-34020
2006
499980
Ewan L.C.,Jopling H.M.,Jia H.,Mittar S.,Bagherzadeh A.,Howell G.J.,Walker J.H.,Zachary I.C.,Ponnambalam S.
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.
Traffic
7
1270-1282
2006
499981
Blanes M.G.,Oubaha M.,Rautureau Y.,Gratton J.P.
Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells.
J. Biol. Chem.
282
10660-10669
2007
499982
Zhang H.,He Y.,Dai S.,Xu Z.,Luo Y.,Wan T.,Luo D.,Jones D.,Tang S.,Chen H.,Sessa W.C.,Min W.
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice.
J. Clin. Invest.
118
3904-3916
2008
499983
Mellberg S.,Dimberg A.,Bahram F.,Hayashi M.,Rennel E.,Ameur A.,Westholm J.O.,Larsson E.,Lindahl P.,Cross M.J.,Claesson-Welsh L.
Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis.
FASEB J.
23
1490-1502
2009
499984
Chabot C.,Spring K.,Gratton J.P.,Elchebly M.,Royal I.
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.
Mol. Cell. Biol.
29
241-253
2009
499985
Zhang Z.,Neiva K.G.,Lingen M.W.,Ellis L.M.,Nor J.E.
VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2.
Cell Death Differ.
17
499-512
2010
499986
Becker J.,Pavlakovic H.,Ludewig F.,Wilting F.,Weich H.A.,Albuquerque R.,Ambati J.,Wilting J.
Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.
Clin. Cancer Res.
16
1431-1441
2010
499987
Nilsson I.,Bahram F.,Li X.,Gualandi L.,Koch S.,Jarvius M.,Soderberg O.,Anisimov A.,Kholova I.,Pytowski B.,Baldwin M.,Yla-Herttuala S.,Alitalo K.,Kreuger J.,Claesson-Welsh L.
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts.
EMBO J.
29
1377-1388
2010
499988
Jopling H.M.,Howell G.J.,Gamper N.,Ponnambalam S.
The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.
Biochem. Biophys. Res. Commun.
410
170-176
2011
499989
Nakao S.,Zandi S.,Hata Y.,Kawahara S.,Arita R.,Schering A.,Sun D.,Melhorn M.I.,Ito Y.,Lara-Castillo N.,Ishibashi T.,Hafezi-Moghadam A.
Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis.
Blood
117
1081-1090
2011
499990
Shibuya M.
Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.
J. Biochem. Mol. Biol.
39
469-478
2006
499991
Holmes K.,Roberts O.L.,Thomas A.M.,Cross M.J.
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
Cell. Signal.
19
2003-2012
2007
499992
Roskoski R. Jr.
VEGF receptor protein-tyrosine kinases: structure and regulation.
Biochem. Biophys. Res. Commun.
375
287-291
2008
499993
Lohela M.,Bry M.,Tammela T.,Alitalo K.
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.
Curr. Opin. Cell Biol.
21
154-165
2009
499994
Grunewald F.S.,Prota A.E.,Giese A.,Ballmer-Hofer K.
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.
Biochim. Biophys. Acta
1804
567-580
2010
499995
Guo S.,Colbert L.S.,Fuller M.,Zhang Y.,Gonzalez-Perez R.R.
Vascular endothelial growth factor receptor-2 in breast cancer.
Biochim. Biophys. Acta
1806
108-121
2010
499996
Shibuya M.
Tyrosine kinase receptor Flt/VEGFR family: its characterization related to angiogenesis and cancer.
Genes Cancer
1
1119-1123
2010
499997
Koch S.,Tugues S.,Li X.,Gualandi L.,Claesson-Welsh L.
Signal transduction by vascular endothelial growth factor receptors.
Biochem. J.
437
169-183
2011
499998
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
499999
Rho S.B.,Song Y.J.,Lim M.C.,Lee S.H.,Kim B.R.,Park S.Y.
Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2.
Cell. Signal.
24
131-139
2012
500000
Tao B.B.,Liu S.Y.,Zhang C.C.,Fu W.,Cai W.J.,Wang Y.,Shen Q.,Wang M.J.,Chen Y.,Zhang L.J.,Zhu Y.Z.,Zhu Y.C.
VEGFR2 functions as an H(2)S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells.
Antioxid. Redox Signal.
19
448-464
2013
500001
Zeng L.,Xiao Q.,Chen M.,Margariti A.,Martin D.,Ivetic A.,Xu H.,Mason J.,Wang W.,Cockerill G.,Mori K.,Li J.Y.,Chien S.,Hu Y.,Xu Q.
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.
Circulation
127
1712-1722
2013
500002
Srinivasan S.,Meyer R.D.,Lugo R.,Rahimi N.
Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2.
J. Biol. Chem.
288
23171-23181
2013
500003
Lin C.,Ear J.,Midde K.,Lopez-Sanchez I.,Aznar N.,Garcia-Marcos M.,Kufareva I.,Abagyan R.,Ghosh P.
Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.
Mol. Biol. Cell
25
3654-3671
2014
500004
Srinivasan S.,Chitalia V.,Meyer R.D.,Hartsough E.,Mehta M.,Harrold I.,Anderson N.,Feng H.,Smith L.E.,Jiang Y.,Costello C.E.,Rahimi N.
Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.
Angiogenesis
18
449-462
2015
500005
Khayati F.,Perez-Cano L.,Maouche K.,Sadoux A.,Boutalbi Z.,Podgorniak M.P.,Maskos U.,Setterblad N.,Janin A.,Calvo F.,Lebbe C.,Menashi S.,Fernandez-Recio J.,Mourah S.
EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.
Oncotarget
6
9766-9780
2015
500006
McTigue M.A.,Wickersham J.A.,Pinko C.,Showalter R.E.,Parast C.V.,Tempczyk-Russell A.,Gehring M.R.,Mroczkowski B.,Kan C.-C.,Villafranca J.E.,Appelt K.
Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.
Structure
7
319-330
1999
500007
Miyazaki Y.,Matsunaga S.,Tang J.,Maeda Y.,Nakano M.,Philippe R.J.,Shibahara M.,Liu W.,Sato H.,Wang L.,Nolte R.T.
Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors.
Bioorg. Med. Chem. Lett.
15
2203-2207
2005
500008
Hodous B.L.,Geuns-Meyer S.D.,Hughes P.E.,Albrecht B.K.,Bellon S.,Bready J.,Caenepeel S.,Cee V.J.,Chaffee S.C.,Coxon A.,Emery M.,Fretland J.,Gallant P.,Gu Y.,Hoffman D.,Johnson R.E.,Kendall R.,Kim J.L.,Long A.M.,Morrison M.,Olivieri P.R.,Patel V.F.,Polverino A.,Rose P.,Tempest P.,Wang L.,Whittington D.A.,Zhao H.
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
J. Med. Chem.
50
611-626
2007
500009
Peifer C.,Selig R.,Kinkel K.,Ott D.,Totzke F.,Schaechtele C.,Heidenreich R.,Roecken M.,Schollmeyer D.,Laufer S.
Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.
J. Med. Chem.
51
3814-3824
2008
500010
Yang Y.,Xie P.,Opatowsky Y.,Schlessinger J.
Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling.
Proc. Natl. Acad. Sci. U.S.A.
107
1906-1911
2010
500011
Leppanen V.M.,Prota A.E.,Jeltsch M.,Anisimov A.,Kalkkinen N.,Strandin T.,Lankinen H.,Goldman A.,Ballmer-Hofer K.,Alitalo K.
Structural determinants of growth factor binding and specificity by VEGF receptor 2.
Proc. Natl. Acad. Sci. U.S.A.
107
2425-2430
2010
500012
Franklin M.C.,Navarro E.C.,Wang Y.,Patel S.,Singh P.,Zhang Y.,Persaud K.,Bari A.,Griffith H.,Shen L.,Balderes P.,Kussie P.
The structural basis for the function of two anti-VEGF receptor 2 antibodies.
Structure
19
1097-1107
2011
500013
Walter J.W.,North P.E.,Waner M.,Mizeracki A.,Blei F.,Walker J.W.T.,Reinisch J.F.,Marchuk D.A.
Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.
Genes Chromosomes Cancer
33
295-303
2002
500014
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006
500015
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
500016
Jinnin M.,Medici D.,Park L.,Limaye N.,Liu Y.,Boscolo E.,Bischoff J.,Vikkula M.,Boye E.,Olsen B.R.
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.
Nat. Med.
14
1236-1246
2008
