Sequence of HMDH_SACS2
EC Number:1.1.1.34
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hydroxymethylglutaryl-CoA reductase (NADPH)
O08424
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
409
44009
Reaction
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Other sequences found for EC No. 1.1.1.34
General information:
Sequence
0 MKIDEVVEKL VKGEISFHEV DNLLEANAAM VARRLALEKI VGVGLPSIGS TVIDYSEIKN
60 KNAENVIGAI QIPLGIVGPI RVNGDYAKGD FYVPMATTEG ALIASVNRGI KAVTLSGGVR
120 AKVLKDEMTR APVFKFDSIE QIPNFLKFIE ENLEKIRNIA NSTSHHGKLK SITPFVLGNN
180 VWLRFSFETG DAMGMNMVTI AVEKVCEFIE ENFPSADCLA VSGNMCSDKK QTNVNSLFGR
240 GKTVVAEALI KKDVIRNILH SNAQLIHDIN LRKNWLGTAR AGSLSQFNAH FANIVTAIFI
300 ATGQDVAQIV ESSSGYTWTE VRGEDLYISV TLPSLEVGTV GGGTRLPTQK EALSIMGVYG
360 SGNPPGSNAK KLAEIIASTV LSGELNLLAA LSNKELGKAH AKLGRAMKV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
43827
Bochar D.A.,Brown J.R.,Doolittle W.F.,Klenk H.-P.,Lam W.,Schenk M.E.,Stauffacher C.V.,Rodwell V.W.
3-hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product.
J. Bacteriol.
179
3632-3638
1997
43828
Charlebois R.L.,Singh R.K.,Chan-Weiher C.C.-Y.,Allard G.,Chow C.,Confalonieri F.,Curtis B.,Duguet M.,Erauso G.,Faguy D.,Gaasterland T.,Garrett R.A.,Gordon P.,Jeffries A.C.,Kozera C.,Kushwaha N.,Lafleur E.,Medina N.,Peng X.,Penny S.L.,She Q.,St Jean A.,van der Oost J.,Young F.,Zivanovic Y.,Doolittle W.F.,Ragan M.A.,Sensen C.W.
Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2.
Genome
43
116-136
2000
43829
She Q.,Singh R.K.,Confalonieri F.,Zivanovic Y.,Allard G.,Awayez M.J.,Chan-Weiher C.C.-Y.,Clausen I.G.,Curtis B.A.,De Moors A.,Erauso G.,Fletcher C.,Gordon P.M.K.,Heikamp-de Jong I.,Jeffries A.C.,Kozera C.J.,Medina N.,Peng X.,Thi-Ngoc H.P.,Redder P.,Schenk M.E.,Theriault C.,Tolstrup N.,Charlebois R.L.,Doolittle W.F.,Duguet M.,Gaasterland T.,Garrett R.A.,Ragan M.A.,Sensen C.W.,Van der Oost J.
The complete genome of the crenarchaeon Sulfolobus solfataricus P2.
Proc. Natl. Acad. Sci. U.S.A.
98
7835-7840
2001
