Sequence of SPEB_STRPY

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
streptopain
P0C0J0
Streptococcus pyogenes
398
43174
Reaction
preferential cleavage with hydrophobic residues at P2, P1 and P1'
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MNKKKLGIRL LSLLALGGFV LANPVFADQN FARNEKEAKD SAITFIQKSA AIKAGARSAE
 60 DIKLDKVNLG GELSGSNMYV YNISTGGFVI VSGDKRSPEI LGYSTSGSFD ANGKENIASF
120 MESYVEQIKE NKKLDTTYAG TAEIKQPVVK SLLDSKGIHY NQGNPYNLLT PVIEKVKPGE
180 QSFVGQHAAT GCVATATAQI MKYHNYPNKG LKDYTYTLSS NNPYFNHPKN LFAAISTRQY
240 NWNNILPTYS GRESNVQKMA ISELMADVGI SVDMDYGPSS GSAGSSRVQR ALKENFGYNQ
300 SVHQINRSDF SKQDWEAQID KELSQNQPVY YQGVGKVGGH AFVIDGADGR NFYHVNWGWG
360 GVSDGFFRLD ALNPSALGTG GGAGGFNGYQ SAVVGIKP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
476409
Hauser A.R.,Schlievert P.M.
Nucleotide sequence of the streptococcal pyrogenic exotoxin type B gene and relationship between the toxin and the streptococcal proteinase precursor.
J. Bacteriol.
172
4536-4542
1990
476410
Kapur V.,Topouzis S.,Majesky M.W.,Li L.L.,Hamrick M.R.,Hamill R.J.,Patti J.M.,Musser J.M.
A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin.
Microb. Pathog.
15
327-346
1993
476413
Tai J.Y.,Kortt A.A.,Liu T.-Y.,Elliott S.D.
Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain.
J. Biol. Chem.
251
1955-1959
1976
476414
Lo S.S.,Fraser B.A.,Liu T.-Y.
The mixed disulfide in the zymogen of streptococcal proteinase. Characterization and implication for its biosynthesis.
J. Biol. Chem.
259
11041-11045
1984
476415
Kuo C.-F.,Wu J.-J.,Tsai P.-J.,Kao F.-J.,Lei H.-Y.,Lin M.T.,Lin Y.-S.
Streptococcal pyrogenic exotoxin B induces apoptosis and reduces phagocytic activity in U937 cells.
Infect. Immun.
67
126-130
1999
476416
Kagawa T.F.,Cooney J.C.,Baker H.M.,McSweeney S.,Liu M.,Gubba S.,Musser J.M.,Baker E.N.
Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
Proc. Natl. Acad. Sci. U.S.A.
97
2235-2240
2000
476417
Olsen J.G.,Dagil R.,Niclasen L.M.,Sorensen O.E.,Kragelund B.B.
Structure of the mature Streptococcal cysteine protease exotoxin mSpeB in its active dimeric form.
J. Mol. Biol.
393
693-703
2009