Sequence of DOPO_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
dopamine beta-monooxygenase
P09172
Homo sapiens
617
69065
Reaction
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MPALSRWASL PGPSMREAAF MYSTAVAIFL VILVAALQGS APRESPLPYH IPLDPEGSLE
 60 LSWNVSYTQE AIHFQLLVRR LKAGVLFGMS DRGELENADL VVLWTDGDTA YFADAWSDQK
120 GQIHLDPQQD YQLLQVQRTP EGLTLLFKRP FGTCDPKDYL IEDGTVHLVY GILEEPFRSL
180 EAINGSGLQM GLQRVQLLKP NIPEPELPSD ACTMEVQAPN IQIPSQETTY WCYIKELPKG
240 FSRHHIIKYE PIVTKGNEAL VHHMEVFQCA PEMDSVPHFS GPCDSKMKPD RLNYCRHVLA
300 AWALGAKAFY YPEEAGLAFG GPGSSRYLRL EVHYHNPLVI EGRNDSSGIR LYYTAKLRRF
360 NAGIMELGLV YTPVMAIPPR ETAFILTGYC TDKCTQLALP PSGIHIFASQ LHTHLTGRKV
420 VTVLVRDGRE WEIVNQDNHY SPHFQEIRML KKVVSVHPGD VLITSCTYNT EDRELATVGG
480 FGILEEMCVN YVHYYPQTQL ELCKSAVDAG FLQKYFHLIN RFNNEDVCTC PQASVSQQFT
540 SVPWNSFNRD VLKALYSFAP ISMHCNKSSA VRFQGEWNLQ PLPKVISTLE EPTPQCPTSQ
600 GRSPAGPTVV SIGGGKG
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
394801
Humphray S.J.,Oliver K.,Hunt A.R.,Plumb R.W.,Loveland J.E.,Howe K.L.,Andrews T.D.,Searle S.,Hunt S.E.,Scott C.E.,Jones M.C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Ashwell R.I.S.,Babbage A.K.,Babbage S.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beasley H.,Beasley O.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Chen Y.,Clarke G.,Clark S.Y.,Clee C.M.,Clegg S.,Collier R.E.,Corby N.,Crosier M.,Cummings A.T.,Davies J.,Dhami P.,Dunn M.,Dutta I.,Dyer L.W.,Earthrowl M.E.,Faulkner L.,Fleming C.J.,Frankish A.,Frankland J.A.,French L.,Fricker D.G.,Garner P.,Garnett J.,Ghori J.,Gilbert J.G.R.,Glison C.,Grafham D.V.,Gribble S.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Guy J.,Hall R.E.,Hammond S.,Harley J.L.,Harrison E.S.I.,Hart E.A.,Heath P.D.,Henderson C.D.,Hopkins B.L.,Howard P.J.,Howden P.J.,Huckle E.,Johnson C.,Johnson D.,Joy A.A.,Kay M.,Keenan S.,Kershaw J.K.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.,Lloyd D.M.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,McLaren S.,McLay K.E.,McMurray A.,Milne S.,Nickerson T.,Nisbett J.,Nordsiek G.,Pearce A.V.,Peck A.I.,Porter K.M.,Pandian R.,Pelan S.,Phillimore B.,Povey S.,Ramsey Y.,Rand V.,Scharfe M.,Sehra H.K.,Shownkeen R.,Sims S.K.,Skuce C.D.,Smith M.,Steward C.A.,Swarbreck D.,Sycamore N.,Tester J.,Thorpe A.,Tracey A.,Tromans A.,Thomas D.W.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Williams S.A.,Wilming L.,Wray P.W.,Young L.,Ashurst J.L.,Coulson A.,Blocker H.,Durbin R.M.,Sulston J.E.,Hubbard T.,Jackson M.J.,Bentley D.R.,Beck S.,Rogers J.,Dunham I.
DNA sequence and analysis of human chromosome 9.
Nature
429
369-374
2004
394802
Lamouroux A.,Vigny A.,Faucon Biguet N.,Darmon M.C.,Franck R.,Henry J.-P.,Mallet J.
The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.
EMBO J.
6
3931-3937
1987
394803
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
394804
Kobayashi K.,Kurosawa Y.,Fukita K.,Nagatsu T.
Human dopamine beta-hydroxylase gene: two mRNA types having different 3'-terminal regions are produced through alternative polyadenylation.
Nucleic Acids Res.
17
1089-1102
1989
394805
Li B.,Tsing S.,Kosaka A.H.,Nguyen B.,Osen E.G.,Bach C.,Chan H.,Barnett J.
Expression of human dopamine beta-hydroxylase in Drosophila Schneider 2 cells.
Biochem. J.
313
57-64
1996
394806
Kobayashi K.,Morita S.,Mizuguchi T.,Sawada H.,Yamada K.,Nagatsu I.,Fujita K.,Nagatsu T.
Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice.
J. Biol. Chem.
269
29725-29731
1994
394807
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
394808
Jia W.,Lu Z.,Fu Y.,Wang H.P.,Wang L.H.,Chi H.,Yuan Z.F.,Zheng Z.B.,Song L.N.,Han H.H.,Liang Y.M.,Wang J.L.,Cai Y.,Zhang Y.K.,Deng Y.L.,Ying W.T.,He S.M.,Qian X.H.
A strategy for precise and large scale identification of core fucosylated glycoproteins.
Mol. Cell. Proteomics
8
913-923
2009
394809
Cubells J.F.,Schroeder J.P.,Barrie E.S.,Manvich D.F.,Sadee W.,Berg T.,Mercer K.,Stowe T.A.,Liles L.C.,Squires K.E.,Mezher A.,Curtin P.,Perdomo D.L.,Szot P.,Weinshenker D.
Human bacterial artificial chromosome (BAC) transgenesis fully rescues noradrenergic function in dopamine beta-hydroxylase knockout mice.
PLoS ONE
11
0-0
2016
394810
Vendelboe T.V.,Harris P.,Zhao Y.,Walter T.S.,Harlos K.,El Omari K.,Christensen H.E.
The crystal structure of human dopamine beta-hydroxylase at 2.9 A resolution.
Sci. Adv.
2
0-0
2016
394811
Williams H.J.,Bray N.,Murphy K.C.,Cardno A.G.,Jones L.A.,Owen M.J.
No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).
Am. J. Med. Genet.
88
557-559
1999
394812
Cargill M.,Altshuler D.,Ireland J.,Sklar P.,Ardlie K.,Patil N.,Shaw N.,Lane C.R.,Lim E.P.,Kalyanaraman N.,Nemesh J.,Ziaugra L.,Friedland L.,Rolfe A.,Warrington J.,Lipshutz R.,Daley G.Q.,Lander E.S.
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Nat. Genet.
22
231-238
1999
394814
Halushka M.K.,Fan J.-B.,Bentley K.,Hsie L.,Shen N.,Weder A.,Cooper R.,Lipshutz R.,Chakravarti A.
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Nat. Genet.
22
239-247
1999
394815
Kim C.-H.,Zabetian C.P.,Cubells J.F.,Cho S.,Biaggioni I.,Cohen B.M.,Robertson D.,Kim K.-S.
Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency.
Am. J. Med. Genet.
108
140-147
2002