Sequence of ACADM_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
medium-chain acyl-CoA dehydrogenase
P11310
Homo sapiens
421
46588
Reaction
a medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MAAGFGRCCR VLRSISRFHW RSQHTKANRQ REPGLGFSFE FTEQQKEFQA TARKFAREEI
 60 IPVAAEYDKT GEYPVPLIRR AWELGLMNTH IPENCGGLGL GTFDACLISE ELAYGCTGVQ
120 TAIEGNSLGQ MPIIIAGNDQ QKKKYLGRMT EEPLMCAYCV TEPGAGSDVA GIKTKAEKKG
180 DEYIINGQKM WITNGGKANW YFLLARSDPD PKAPANKAFT GFIVEADTPG IQIGRKELNM
240 GQRCSDTRGI VFEDVKVPKE NVLIGDGAGF KVAMGAFDKT RPVVAAGAVG LAQRALDEAT
300 KYALERKTFG KLLVEHQAIS FMLAEMAMKV ELARMSYQRA AWEVDSGRRN TYYASIAKAF
360 AGDIANQLAT DAVQILGGNG FNTEYPVEKL MRDAKIYQIY EGTSQIQRLI VAREHIDKYK
420 N
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
380033
Kelly D.P.,Kim J.-J.P.,Billadello J.J.,Hainline B.E.,Chu T.W.,Strauss A.W.
Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue.
Proc. Natl. Acad. Sci. U.S.A.
84
4068-4072
1987
380034
Zhang Z.F.,Kelly D.P.,Kim J.-J.P.,Zhou Y.Q.,Ogden M.L.,Whelan A.J.,Strauss A.W.
Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase gene.
Biochemistry
31
81-89
1992
380036
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
380037
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
380039
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
380041
Matsubara Y.,Narisawa K.,Miyabayashi S.,Tada K.,Coates P.M.,Bachmann C.,Elsas L.J. II,Pollitt R.J.,Rhead W.J.,Roe C.R.
Identification of a common mutation in patients with medium-chain acyl-CoA dehydrogenase deficiency.
Biochem. Biophys. Res. Commun.
171
498-505
1990
380042
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
380043
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
380044
Bharathi S.S.,Zhang Y.,Mohsen A.W.,Uppala R.,Balasubramani M.,Schreiber E.,Uechi G.,Beck M.E.,Rardin M.J.,Vockley J.,Verdin E.,Gibson B.W.,Hirschey M.D.,Goetzman E.S.
SIRT3 regulates long-chain acyl-coA dehydrogenase by deacetylating conserved lysines near the active site.
J. Biol. Chem.
288
33837-33847
2013
380045
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
380046
Malecki J.,Ho A.Y.,Moen A.,Dahl H.A.,Falnes P.O.
Human METTL20 is a mitochondrial lysine methyltransferase that targets the beta subunit of electron transfer flavoprotein (ETFbeta) and modulates its activity.
J. Biol. Chem.
290
423-434
2015
380047
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
380048
Lee H.J.,Wang M.,Paschke R.,Nandy A.,Ghisla S.,Kim J.-J.P.
Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
Biochemistry
35
12412-12420
1996
380049
Toogood H.S.,van Thiel A.,Basran J.,Sutcliffe M.J.,Scrutton N.S.,Leys D.
Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain acyl-CoA dehydrogenase complex.
J. Biol. Chem.
279
32904-32912
2004
380050
Toogood H.S.,van Thiel A.,Scrutton N.S.,Leys D.
Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein.
J. Biol. Chem.
280
30361-30366
2005
380051
Tanaka K.,Yokota I.,Coates P.M.,Strauss A.W.,Kelly D.P.,Zhang Z.F.,Gregersen N.,Andresen B.S.,Matsubara Y.,Curtis D.,Chen Y.-T.
Mutations in the medium chain acyl-CoA dehydrogenase (MCAD) gene.
Hum. Mutat.
1
271-279
1992
380052
Yokota I.,Indo Y.,Coates P.M.,Tanaka K.
Molecular basis of medium chain acyl-coenzyme A dehydrogenase deficiency. An A to G transition at position 985 that causes a lysine-304 to glutamate substitution in the mature protein is the single prevalent mutation.
J. Clin. Invest.
86
1000-1003
1990
380053
Kelly D.P.,Whelan A.J.,Ogden M.L.,Alpers R.,Zhang Z.F.,Bellus G.,Gregersen N.,Dorland L.,Strauss A.W.
Molecular characterization of inherited medium-chain acyl-CoA dehydrogenase deficiency.
Proc. Natl. Acad. Sci. U.S.A.
87
9236-9240
1990
380054
Yokota I.,Coates P.M.,Hale D.E.,Rinaldo P.,Tanaka K.
Molecular survey of a prevalent mutation, 985A-to-G transition, and identification of five infrequent mutations in the medium-chain Acyl-CoA dehydrogenase (MCAD) gene in 55 patients with MCAD deficiency.
Am. J. Hum. Genet.
49
1280-1291
1991
380055
Gregersen N.,Andresen B.S.,Bross P.,Winter V.,Ruediger N.,Engst S.,Christensen E.,Kelly D.,Strauss A.W.,Koelvraa S.,Bolund L.,Ghisla S.
Molecular characterization of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: identification of a lys329 to glu mutation in the MCAD gene, and expression of inactive mutant enzyme protein in E. coli.
Hum. Genet.
86
545-551
1991
380056
Blakemore A.I.,Singleton H.,Pollitt R.J.,Engel P.C.,Kolvraa S.,Gregersen N.,Curtis D.
Frequency of the G985 MCAD mutation in the general population.
Lancet
337
298-299
1991
380057
Andresen B.S.,Jensen T.G.,Bross P.,Knudsen I.,Winter V.,Koelvraa S.,Bolund L.,Ding J.-H.,Chen Y.-T.,van Hove J.L.K.,Curtis D.,Yokota I.,Tanaka K.,Kim J.-J.P.,Gregersen N.
Disease-causing mutations in exon 11 of the medium-chain acyl-CoA dehydrogenase gene.
Am. J. Hum. Genet.
54
975-988
1994
380058
Ziadeh R.,Hoffman E.P.,Finegold D.N.,Hoop R.C.,Brackett J.C.,Strauss A.W.,Naylor E.W.
Medium chain acyl-CoA dehydrogenase deficiency in Pennsylvania: neonatal screening shows high incidence and unexpected mutation frequencies.
Pediatr. Res.
37
675-678
1995
380059
Brackett J.C.,Sims H.F.,Steiner R.D.,Nunge M.,Zimmerman E.M.,Demartinville B.,Rinaldo P.,Slaugh R.,Strauss A.W.
A novel mutation in medium chain acyl-CoA dehydrogenase causes sudden neonatal death.
J. Clin. Invest.
94
1477-1483
1994
380060
Andresen B.S.,Bross P.,Udvari S.,Kirk J.,Gray G.,Kmoch S.,Chamoles N.,Knudsen I.,Winter V.,Wilcken B.,Yokota I.,Hart K.,Packman S.,Harpey J.P.,Saudubray J.-M.,Hale D.E.,Bolund L.,Koelvraa S.,Gregersen N.
The molecular basis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in compound heterozygous patients: is there correlation between genotype and phenotype?
Hum. Mol. Genet.
6
695-707
1997
380061
Kuchler B.,Abdel-Ghany A.G.,Bross P.,Nandy A.,Rasched I.,Ghisla S.
Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site.
Biochem. J.
337
225-230
1999
380062
Yang B.-Z.,Ding J.-H.,Zhou C.,Dimachkie M.M.,Sweetman L.,Dasouki M.J.,Wilkinson J.,Roe C.R.
Identification of a novel mutation in patients with medium-chain acyl-CoA dehydrogenase deficiency.
Mol. Genet. Metab.
69
259-262
2000
380063
Andresen B.S.,Dobrowolski S.F.,O'Reilly L.,Muenzer J.,McCandless S.E.,Frazier D.M.,Udvari S.,Bross P.,Knudsen I.,Banas R.,Chace D.H.,Engel P.C.,Naylor E.W.,Gregersen N.
Medium-chain acyl-CoA dehydrogenase (MCAD) mutations identified by MS/MS-based prospective screening of newborns differ from those observed in patients with clinical symptoms: identification and characterization of a new, prevalent mutation that results in mild MCAD deficiency.
Am. J. Hum. Genet.
68
1408-1418
2001
380064
Zschocke J.,Schulze A.,Lindner M.,Fiesel S.,Olgemoller K.,Hoffmann G.F.,Penzien J.,Ruiter J.P.N.,Wanders R.J.A.,Mayatepek E.
Molecular and functional characterization of mild MCAD deficiency.
Hum. Genet.
108
404-408
2001
380065
Albers S.,Levy H.L.,Irons M.,Strauss A.W.,Marsden D.
Compound heterozygosity in four asymptomatic siblings with medium-chain acyl-CoA dehydrogenase deficiency.
J. Inherit. Metab. Dis.
24
417-418
2001
380066
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006