Sequence of POL_SIVSP

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
retroviral ribonuclease H
P19505
Simian immunodeficiency virus (isolate PBj14/BCL-3)
1449
163326
Reaction
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Sequences with same EC No.
Sequence
show sequence in fasta format
   0 MGARNSVLSG KKADELEKIR LRPGGKKRYQ LKHIVWAANE LDRFGLAESL LENKEGCQKI
  60 LSVLAPLVPT GSENLKSLYN TVCVLWCIHA EEKVKHTEEA KQIVQRHLVV ETGTADKMPA
 120 TSRPTAPPSG KGGNYPVQQI GGNYTHLPLS PRTLNAWVKL IEEKKFGAEV VPGFQALSEG
 180 CTPYDINQML NCVGEHQAAM QIIREIINEE AADWDLQHPQ PGPIPPGQLR EPRGSDIAGT
 240 TSTVDEQIQW MYRQQNPIPV GNIYRRWIQL GLQKCVRMYN PTNILDVKQG PKEPFQSYVD
 300 RFYKSLRAEQ TDPAVKNWMT QTLLIQNANP DCKLVLKGLG INPTLEEMLT ACQGVGGPGQ
 360 KARLMAEALK DALTQGPLPF AAVQQKGQRK IIKCWNCGKE GHSARQCRAP RRQGCWKCGK
 420 AGHVMAKCPE RQAGFFRAWP MGKEAPQFPH GPDASGADTN CSPRGSSCGS TEELHEDGQK
 480 AEGEQRETLQ GGNGGFAAPQ FSLWRRPIVT AYIEEQPVEV LLDTGADDSI VAGIELGPNY
 540 TPKIVGGIGG FINTKEYKDV KIKVLGKVIK GTIMTGDTPI NIFGRNLLTA MGMSLNLPIA
 600 KVEPIKVTLK PGKDGPKLRQ WPLSKEKIIA LREICEKMEK DGQLEEAPPT NPYNTPTFAI
 660 KKKDKNKWRM LIDFRELNKV TQDFTEVQLG IPHPAGLAKR RRITVLDVGD AYFSIPLDEE
 720 FRQYTAFTLP SVNNAEPGKR YIYKVLPQGW KGSPAIFQHT MRNVLEPFRK ANPDVTLIQY
 780 MDDILIASDR TDLEHDRVVL QLKELLNSIG FSTPEEKFQK DPPFQWMGYE LWPTKWKLQK
 840 IELPQRETWT VNDIQKLVGV LNWAAQIYPG IKTKHLCRLI RGKMTLTEEV QWTEMAEAEY
 900 EENKIILSQE QEGCYYQEGK PLEATVIKSQ DNQWSYKIHQ EDKILKVGKF AKIKNTHTNG
 960 VRLLAHVVQK IGKEAIVIWG QVPRFHLPVE REIWEQWWTD YWQVTWIPEW DFVSTPPLVR
1020 LVFNLVKEPI QGAETFYVDG SCNRQSREGK AGYVTDRGRD KAKLLEQTTN QQAELEAFYL
1080 ALADSGPKAN IIVDSQYVMG IVAGQPTESE SRLVNQIIEE MIKKEAIYVA WVPAHKGIGG
1140 NQEVDHLVSQ GIRQVLFLEK IEPAQEEHEK YHSNVKELVF KFGLPRLVAK QIVDTCDKCH
1200 QKGEAIHGQV NAELGTWQMD CTHLEGKIII VAVHVASGFI EAEVIPQETG RQTALFLLKL
1260 ASRWPITHLH TDNGANFTSQ EVKMVAWWAG IEQTFGVPYN PQSQGVVEAM NHHLKTQIDR
1320 IREQANSIET IVLMAVHCMN FKRRGGIGDM TPAERLVNMI TTEQEIQFQQ SKNSKFKNFR
1380 VYYREGRDQL WKGPGELLWK GEGAVILKVG TEIKVVPRRK AKIIKDYGGG KELDSGSHLE
1440 DTGEAREVA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
326015
Dewhurst S.,Embretson J.E.,Anderson D.C.,Mullins J.I.,Fultz P.N.
Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM-PBj14.
Nature
345
636-640
1990
326016
Dewhurst S.,Embretson J.E.,Fultz P.N.,Mullins J.I.
Molecular clones from a non-acutely pathogenic derivative of SIVsmmPBj14: characterization and comparison to acutely pathogenic clones.
AIDS Res. Hum. Retroviruses
8
1179-1187
1992