Sequence of LYS12_YEAST

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
homoisocitrate dehydrogenase
P40495
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
371
40069
Reaction
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MFRSVATRLS ACRGLASNAA RKSLTIGLIP GDGIGKEVIP AGKQVLENLN SKHGLSFNFI
 60 DLYAGFQTFQ ETGKALPDET VKVLKEQCQG ALFGAVQSPT TKVEGYSSPI VALRREMGLF
120 ANVRPVKSVE GEKGKPIDMV IVRENTEDLY IKIEKTYIDK ATGTRVADAT KRISEIATRR
180 IATIALDIAL KRLQTRGQAT LTVTHKSNVL SQSDGLFREI CKEVYESNKD KYGQIKYNEQ
240 IVDSMVYRLF REPQCFDVIV APNLYGDILS DGAAALVGSL GVVPSANVGP EIVIGEPCHG
300 SAPDIAGKGI ANPIATIRST ALMLEFLGHN EAAQDIYKAV DANLREGSIK TPDLGGKAST
360 QQVVDDVLSR L
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
306934
Churcher C.M.,Bowman S.,Badcock K.,Bankier A.T.,Brown D.,Chillingworth T.,Connor R.,Devlin K.,Gentles S.,Hamlin N.,Harris D.E.,Horsnell T.,Hunt S.,Jagels K.,Jones M.,Lye G.,Moule S.,Odell C.,Pearson D.,Rajandream M.A.,Rice P.,Rowley N.,Skelton J.,Smith V.,Walsh S.V.,Whitehead S.,Barrell B.G.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.
Nature
387
84-87
1997
306935
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
306937
Strassman M.,Ceci L.N.
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.
J. Biol. Chem.
240
4357-4361
1965
306938
Rowley B.,Tucci A.F.
Homoisocitric dehydrogenase from yeast.
Arch. Biochem. Biophys.
141
499-510
1970
306939
Urrestarazu L.A.,Borell C.W.,Bhattacharjee J.K.
General and specific controls of lysine biosynthesis in Saccharomyces cerevisiae.
Curr. Genet.
9
341-344
1985
306940
Shevchenko A.,Jensen O.N.,Podtelejnikov A.V.,Sagliocco F.,Wilm M.,Vorm O.,Mortensen P.,Shevchenko A.,Boucherie H.,Mann M.
Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels.
Proc. Natl. Acad. Sci. U.S.A.
93
14440-14445
1996
306941
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
306942
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
306943
Sickmann A.,Reinders J.,Wagner Y.,Joppich C.,Zahedi R.P.,Meyer H.E.,Schoenfisch B.,Perschil I.,Chacinska A.,Guiard B.,Rehling P.,Pfanner N.,Meisinger C.
The proteome of Saccharomyces cerevisiae mitochondria.
Proc. Natl. Acad. Sci. U.S.A.
100
13207-13212
2003
306944
Lin Y.,Alguindigue S.S.,Volkman J.,Nicholas K.M.,West A.H.,Cook P.F.
Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Biochemistry
46
890-898
2007
306945
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
306946
Lin Y.,West A.H.,Cook P.F.
Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Biochemistry
48
7305-7312
2009