Sequence of HOA4_PARXL

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
4-hydroxy-2-oxohexanoate aldolase
P51015
Paraburkholderia xenovorans (strain LB400)
346
36798
Reaction
(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MKLEGKKVTV HDMTLRDGMH PKRHQMTLEQ MKSIACGLDA AGIPLIEVTH GDGLGGSSVN
 60 YGFPAHSDEE YLGAVIPLMK QAKVSALLLP GIGTVEHLKM AKDLGVNTIR VATHCTEADV
120 SEQHITQSRK LGLDTVGFLM MAHMASPEKL VSQALLMQGY GANCIYVTDS AGYMLPDDVK
180 ARLSAVRAAL KPETELGFHG HHNLAMGVAN SIAAIEAGAT RIDAAAAGLG AGAGNTPMEV
240 FIAVCARMGI ETGVDVFKIQ DVAEDLVVPI MDHVIRIDRD SLTLGYAGVY SSFLLFAKRA
300 SAKYGVPARD ILVELGRRGM VGGQEDMIED TAMTMARERG LTLTAA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
294400
Hofer B.,Backhaus S.,Timmis K.N.
The biphenyl/polychlorinated biphenyl-degradation locus (bph) of Pseudomonas sp. LB400 encodes four additional metabolic enzymes.
Gene
144
9-16
1994
294401
Chain P.S.G.,Denef V.J.,Konstantinidis K.T.,Vergez L.M.,Agullo L.,Reyes V.L.,Hauser L.,Cordova M.,Gomez L.,Gonzalez M.,Land M.,Lao V.,Larimer F.,LiPuma J.J.,Mahenthiralingam E.,Malfatti S.A.,Marx C.J.,Parnell J.J.,Ramette A.,Richardson P.,Seeger M.,Smith D.,Spilker T.,Sul W.J.,Tsoi T.V.,Ulrich L.E.,Zhulin I.B.,Tiedje J.M.
Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility.
Proc. Natl. Acad. Sci. U.S.A.
103
15280-15287
2006
294402
Baker P.,Pan D.,Carere J.,Rossi A.,Wang W.,Seah S.Y.K.
Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.
Biochemistry
48
6551-6558
2009
294403
Wang W.,Baker P.,Seah S.Y.
Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling.
Biochemistry
49
3774-3782
2010
294404
Baker P.,Carere J.,Seah S.Y.
Probing the molecular basis of substrate specificity, stereospecificity, and catalysis in the class II pyruvate aldolase, BphI.
Biochemistry
50
3559-3569
2011
294405
Carere J.,Baker P.,Seah S.Y.
Investigating the molecular determinants for substrate channeling in BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls degradation pathway.
Biochemistry
50
8407-8416
2011
294406
Baker P.,Seah S.Y.
Rational design of stereoselectivity in the class II pyruvate aldolase BphI.
J. Am. Chem. Soc.
134
507-513
2012