Sequence of EGLN3_HUMAN

hypoxia-inducible factor-proline dioxygenase

Q9H6Z9

239

27261

29451

Taylor M.S.

Characterization and comparative analysis of the EGLN gene family.

Gene

275

125-132

2001

29452

Hirsila M.,Koivunen P.,Gunzler V.,Kivirikko K.I.,Myllyharju J.

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.

J. Biol. Chem.

278

30772-30780

2003

29453

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

29454

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

29455

Epstein A.C.R.,Gleadle J.M.,McNeill L.A.,Hewitson K.S.,O'Rourke J.,Mole D.R.,Mukherji M.,Metzen E.,Wilson M.I.,Dhanda A.,Tian Y.M.,Masson N.,Hamilton D.L.,Jaakkola P.,Barstead R.,Hodgkin J.,Maxwell P.H.,Pugh C.W.,Schofield C.J.,Ratcliffe P.J.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Cell

107

43-54

2001

29456

Semenza G.L.

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

Cell

107

1-3

2001

29457

Bruick R.K.,McKnight S.L.

A conserved family of prolyl-4-hydroxylases that modify HIF.

Science

294

1337-1340

2001

29458

Oehme F.,Ellinghaus P.,Kolkhof P.,Smith T.J.,Ramakrishnan S.,Huetter J.,Schramm M.,Flamme I.

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.

Biochem. Biophys. Res. Commun.

296

343-349

2002

29459

Huang J.,Zhao Q.,Mooney S.M.,Lee F.S.

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

J. Biol. Chem.

277

39792-39800

2002

29460

Cioffi C.L.,Qin Liu X.,Kosinski P.A.,Garay M.,Bowen B.R.

Differential regulation of HIF-1alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells.

Biochem. Biophys. Res. Commun.

303

947-953

2003

29461

Metzen E.,Berchner-Pfannschmidt U.,Stengel P.,Marxsen J.H.,Stolze I.,Klinger M.,Huang W.Q.,Wotzlaw C.,Hellwig-Burgel T.,Jelkmann W.,Acker H.,Fandrey J.

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

J. Cell Sci.

116

1319-1326

2003

29462

Appelhoff R.J.,Tian Y.M.,Raval R.R.,Turley H.,Harris A.L.,Pugh C.W.,Ratcliffe P.J.,Gleadle J.M.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

J. Biol. Chem.

279

38458-38465

2004

29463

Lee S.,Nakamura E.,Yang H.,Wei W.,Linggi M.S.,Sajan M.P.,Farese R.V.,Freeman R.S.,Carter B.D.,Kaelin W.G. Jr.,Schlisio S.

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

Cancer Cell

8

155-167

2005

29464

Koeditz J.,Nesper J.,Wottawa M.,Stiehl D.P.,Camenisch G.,Franke C.,Myllyharju J.,Wenger R.H.,Katschinski D.M.

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

Blood

110

3610-3617

2007

29465

Xie L.,Xiao K.,Whalen E.J.,Forrester M.T.,Freeman R.S.,Fong G.,Gygi S.P.,Lefkowitz R.J.,Stamler J.S.

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Sci. Signal.

2

0-0

2009

29466

Liu Y.,Huo Z.,Yan B.,Lin X.,Zhou Z.N.,Liang X.,Zhu W.,Liang D.,Li L.,Liu Y.,Zhao H.,Sun Y.,Chen Y.H.

Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells.

Biochem. Biophys. Res. Commun.

401

231-237

2010

29467

Su Y.,Loos M.,Giese N.,Hines O.J.,Diebold I.,Gorlach A.,Metzen E.,Pastorekova S.,Friess H.,Buchler P.

PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer.

Br. J. Cancer

103

1571-1579

2010

29468

Yan B.,Jiao S.,Zhang H.S.,Lv D.D.,Xue J.,Fan L.,Wu G.H.,Fang J.

Prolyl hydroxylase domain protein 3 targets Pax2 for destruction.

Biochem. Biophys. Res. Commun.

409

315-320

2011

29469

Pappalardi M.B.,McNulty D.E.,Martin J.D.,Fisher K.E.,Jiang Y.,Burns M.C.,Zhao H.,Ho T.,Sweitzer S.,Schwartz B.,Annan R.S.,Copeland R.A.,Tummino P.J.,Luo L.

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Biochem. J.

436

363-369

2011

29470

Luo W.,Hu H.,Chang R.,Zhong J.,Knabel M.,O'Meally R.,Cole R.N.,Pandey A.,Semenza G.L.

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Cell

145

732-744

2011

29471

Chen N.,Rinner O.,Czernik D.,Nytko K.J.,Zheng D.,Stiehl D.P.,Zamboni N.,Gstaiger M.,Frei C.

The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

Cell Res.

21

983-986

2011

29472

Walmsley S.R.,Chilvers E.R.,Thompson A.A.,Vaughan K.,Marriott H.M.,Parker L.C.,Shaw G.,Parmar S.,Schneider M.,Sabroe I.,Dockrell D.H.,Milo M.,Taylor C.T.,Johnson R.S.,Pugh C.W.,Ratcliffe P.J.,Maxwell P.H.,Carmeliet P.,Whyte M.K.

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

J. Clin. Invest.

121

1053-1063

2011

29473

Geng Z.,Zhu J.,Cao J.,Geng J.,Song X.,Zhang Z.,Bian N.,Wang Z.

Effects of polynitrogen compounds on the activity of recombinant human HIF-1alpha prolyl hydroxylase 3 in E. coli.

J. Inorg. Biochem.

105

391-399

2011

29474

Xie L.,Pi X.,Mishra A.,Fong G.,Peng J.,Patterson C.

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.

J. Clin. Invest.

122

2827-2836

2012

29475

Foxler D.E.,Bridge K.S.,James V.,Webb T.M.,Mee M.,Wong S.C.,Feng Y.,Constantin-Teodosiu D.,Petursdottir T.E.,Bjornsson J.,Ingvarsson S.,Ratcliffe P.J.,Longmore G.D.,Sharp T.V.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Nat. Cell Biol.

14

201-208

2012