Sequence of EGLN2_HUMAN

hypoxia-inducible factor-proline dioxygenase

Q96KS0

407

43650

29414

Taylor M.S.

Characterization and comparative analysis of the EGLN gene family.

Gene

275

125-132

2001

29415

Seth P.,Krop I.,Porter D.,Polyak K.

Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression).

Oncogene

21

836-843

2002

29416

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

29417

Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.

The full-ORF clone resource of the German cDNA consortium.

BMC Genomics

8

399-399

2007

29418

Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.

The DNA sequence and biology of human chromosome 19.

Nature

428

529-535

2004

29420

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

29421

Semenza G.L.

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

Cell

107

1-3

2001

29422

Epstein A.C.R.,Gleadle J.M.,McNeill L.A.,Hewitson K.S.,O'Rourke J.,Mole D.R.,Mukherji M.,Metzen E.,Wilson M.I.,Dhanda A.,Tian Y.M.,Masson N.,Hamilton D.L.,Jaakkola P.,Barstead R.,Hodgkin J.,Maxwell P.H.,Pugh C.W.,Schofield C.J.,Ratcliffe P.J.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Cell

107

43-54

2001

29423

Oehme F.,Ellinghaus P.,Kolkhof P.,Smith T.J.,Ramakrishnan S.,Huetter J.,Schramm M.,Flamme I.

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.

Biochem. Biophys. Res. Commun.

296

343-349

2002

29424

McNeill L.A.,Hewitson K.S.,Gleadle J.M.,Horsfall L.E.,Oldham N.J.,Maxwell P.H.,Pugh C.W.,Ratcliffe P.J.,Schofield C.J.

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

Bioorg. Med. Chem. Lett.

12

1547-1550

2002

29425

Huang J.,Zhao Q.,Mooney S.M.,Lee F.S.

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

J. Biol. Chem.

277

39792-39800

2002

29426

Metzen E.,Berchner-Pfannschmidt U.,Stengel P.,Marxsen J.H.,Stolze I.,Klinger M.,Huang W.Q.,Wotzlaw C.,Hellwig-Burgel T.,Jelkmann W.,Acker H.,Fandrey J.

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

J. Cell Sci.

116

1319-1326

2003

29427

Appelhoff R.J.,Tian Y.M.,Raval R.R.,Turley H.,Harris A.L.,Pugh C.W.,Ratcliffe P.J.,Gleadle J.M.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

J. Biol. Chem.

279

38458-38465

2004

29428

Cobb R.R.,McClary J.,Manzana W.,Finster S.,Larsen B.,Blasko E.,Pearson J.,Biancalana S.,Kauser K.,Bringmann P.,Light D.R.,Schirm S.

Cloning and characterization of the rat HIF-1 alpha prolyl-4-hydroxylase-1 gene.

Protein Expr. Purif.

42

295-304

2005

29429

Tian Y.M.,Mole D.R.,Ratcliffe P.J.,Gleadle J.M.

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.

Biochem. J.

397

179-186

2006

29430

Cummins E.P.,Berra E.,Comerford K.M.,Ginouves A.,Fitzgerald K.T.,Seeballuck F.,Godson C.,Nielsen J.E.,Moynagh P.,Pouyssegur J.,Taylor C.T.

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.

Proc. Natl. Acad. Sci. U.S.A.

103

18154-18159

2006

29431

Steinhoff A.,Pientka F.K.,Mockel S.,Kettelhake A.,Hartmann E.,Kohler M.,Depping R.

Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.

Biochem. Biophys. Res. Commun.

387

705-711

2009

29432

Yasumoto K.,Kowata Y.,Yoshida A.,Torii S.,Sogawa K.

Role of the intracellular localization of HIF-prolyl hydroxylases.

Biochim. Biophys. Acta

1793

792-797

2009

29433

Pappalardi M.B.,McNulty D.E.,Martin J.D.,Fisher K.E.,Jiang Y.,Burns M.C.,Zhao H.,Ho T.,Sweitzer S.,Schwartz B.,Annan R.S.,Copeland R.A.,Tummino P.J.,Luo L.

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Biochem. J.

436

363-369

2011

29434

Foxler D.E.,Bridge K.S.,James V.,Webb T.M.,Mee M.,Wong S.C.,Feng Y.,Constantin-Teodosiu D.,Petursdottir T.E.,Bjornsson J.,Ingvarsson S.,Ratcliffe P.J.,Longmore G.D.,Sharp T.V.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Nat. Cell Biol.

14

201-208

2012

29435

Moser S.C.,Bensaddek D.,Ortmann B.,Maure J.F.,Mudie S.,Blow J.J.,Lamond A.I.,Swedlow J.R.,Rocha S.

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192.

Dev. Cell

26

381-392

2013

29436

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

29437

Ahmed S.,Ayscough A.,Barker G.R.,Canning H.E.,Davenport R.,Downham R.,Harrison D.,Jenkins K.,Kinsella N.,Livermore D.G.,Wright S.,Ivetac A.D.,Skene R.,Wilkens S.J.,Webster N.A.,Hendrick A.G.

1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.

J. Med. Chem.

60

5663-5672

2017