Sequence of EGLN1_HUMAN
EC Number:1.14.11.29
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 = hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
Other sequences found for EC No. 1.14.11.29
General information:
Sequence
0 MANDSGGPGG PSPSERDRQY CELCGKMENL LRCSRCRSSF YCCKEHQRQD WKKHKLVCQG
60 SEGALGHGVG PHQHSGPAPP AAVPPPRAGA REPRKAAARR DNASGDAAKG KVKAKPPADP
120 AAAASPCRAA AGGQGSAVAA EAEPGKEEPP ARSSLFQEKA NLYPPSNTPG DALSPGGGLR
180 PNGQTKPLPA LKLALEYIVP CMNKHGICVV DDFLGKETGQ QIGDEVRALH DTGKFTDGQL
240 VSQKSDSSKD IRGDKITWIE GKEPGCETIG LLMSSMDDLI RHCNGKLGSY KINGRTKAMV
300 ACYPGNGTGY VRHVDNPNGD GRCVTCIYYL NKDWDAKVSG GILRIFPEGK AQFADIEPKF
360 DRLLFFWSDR RNPHEVQPAY ATRYAITVWY FDADERARAK VKYLTGEKGV RVELNKPSDS
420 VGKDVF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
29360
Dupuy D.,Aubert I.,Duperat V.G.,Petit J.,Taine L.,Stef M.,Bloch B.,Arveiler B.
Mapping, characterization, and expression analysis of the SM-20 human homologue, C1orf12, and identification of a novel related gene, SCAND2.
Genomics
69
348-354
2000
29361
Taylor M.S.
Characterization and comparative analysis of the EGLN gene family.
Gene
275
125-132
2001
29362
Hirsila M.,Koivunen P.,Gunzler V.,Kivirikko K.I.,Myllyharju J.
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.
J. Biol. Chem.
278
30772-30780
2003
29363
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
29364
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
29366
Semenza G.L.
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
Cell
107
1-3
2001
29367
Epstein A.C.R.,Gleadle J.M.,McNeill L.A.,Hewitson K.S.,O'Rourke J.,Mole D.R.,Mukherji M.,Metzen E.,Wilson M.I.,Dhanda A.,Tian Y.M.,Masson N.,Hamilton D.L.,Jaakkola P.,Barstead R.,Hodgkin J.,Maxwell P.H.,Pugh C.W.,Schofield C.J.,Ratcliffe P.J.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Cell
107
43-54
2001
29368
Huang J.,Zhao Q.,Mooney S.M.,Lee F.S.
Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.
J. Biol. Chem.
277
39792-39800
2002
29369
Ivan M.,Haberberger T.,Gervasi D.C.,Michelson K.S.,Guenzler V.,Kondo K.,Yang H.,Sorokina I.,Conaway R.C.,Conaway J.W.,Kaelin W.G. Jr.
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Proc. Natl. Acad. Sci. U.S.A.
99
13459-13464
2002
29370
Oehme F.,Ellinghaus P.,Kolkhof P.,Smith T.J.,Ramakrishnan S.,Huetter J.,Schramm M.,Flamme I.
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors.
Biochem. Biophys. Res. Commun.
296
343-349
2002
29371
Cioffi C.L.,Qin Liu X.,Kosinski P.A.,Garay M.,Bowen B.R.
Differential regulation of HIF-1alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells.
Biochem. Biophys. Res. Commun.
303
947-953
2003
29372
Metzen E.,Berchner-Pfannschmidt U.,Stengel P.,Marxsen J.H.,Stolze I.,Klinger M.,Huang W.Q.,Wotzlaw C.,Hellwig-Burgel T.,Jelkmann W.,Acker H.,Fandrey J.
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.
J. Cell Sci.
116
1319-1326
2003
29373
Appelhoff R.J.,Tian Y.M.,Raval R.R.,Turley H.,Harris A.L.,Pugh C.W.,Ratcliffe P.J.,Gleadle J.M.
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
J. Biol. Chem.
279
38458-38465
2004
29374
Ozer A.,Wu L.C.,Bruick R.K.
The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).
Proc. Natl. Acad. Sci. U.S.A.
102
7481-7486
2005
29375
Flashman E.,Bagg E.A.,Chowdhury R.,Mecinovic J.,Loenarz C.,McDonough M.A.,Hewitson K.S.,Schofield C.J.
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
J. Biol. Chem.
283
3808-3815
2008
29376
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
29377
Steinhoff A.,Pientka F.K.,Mockel S.,Kettelhake A.,Hartmann E.,Kohler M.,Depping R.
Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.
Biochem. Biophys. Res. Commun.
387
705-711
2009
29378
Yasumoto K.,Kowata Y.,Yoshida A.,Torii S.,Sogawa K.
Role of the intracellular localization of HIF-prolyl hydroxylases.
Biochim. Biophys. Acta
1793
792-797
2009
29379
Furlow P.W.,Percy M.J.,Sutherland S.,Bierl C.,McMullin M.F.,Master S.R.,Lappin T.R.,Lee F.S.
Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.
J. Biol. Chem.
284
9050-9058
2009
29380
Flashman E.,Hoffart L.M.,Hamed R.B.,Bollinger J.M. Jr.,Krebs C.,Schofield C.J.
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
FEBS J.
277
4089-4099
2010
29381
Bigham A.,Bauchet M.,Pinto D.,Mao X.,Akey J.M.,Mei R.,Scherer S.W.,Julian C.G.,Wilson M.J.,Lopez Herraez D.,Brutsaert T.,Parra E.J.,Moore L.G.,Shriver M.D.
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data.
PLoS Genet.
6
0-0
2010
29382
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
29383
Simonson T.S.,Yang Y.,Huff C.D.,Yun H.,Qin G.,Witherspoon D.J.,Bai Z.,Lorenzo F.R.,Xing J.,Jorde L.B.,Prchal J.T.,Ge R.
Genetic evidence for high-altitude adaptation in Tibet.
Science
329
72-75
2010
29384
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
29385
Su Y.,Loos M.,Giese N.,Metzen E.,Buchler M.W.,Friess H.,Kornberg A.,Buchler P.
Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer.
Cancer
118
960-972
2012
29386
Foxler D.E.,Bridge K.S.,James V.,Webb T.M.,Mee M.,Wong S.C.,Feng Y.,Constantin-Teodosiu D.,Petursdottir T.E.,Bjornsson J.,Ingvarsson S.,Ratcliffe P.J.,Longmore G.D.,Sharp T.V.
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
Nat. Cell Biol.
14
201-208
2012
29387
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
29388
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
29389
Seo K.S.,Park J.H.,Heo J.Y.,Jing K.,Han J.,Min K.N.,Kim C.,Koh G.Y.,Lim K.,Kang G.Y.,Uee Lee J.,Yim Y.H.,Shong M.,Kwak T.H.,Kweon G.R.
SIRT2 regulates tumour hypoxia response by promoting HIF-1alpha hydroxylation.
Oncogene
34
1354-1362
2015
29390
Kumar P.,Gullberg U.,Olsson I.,Ajore R.
Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.
PLoS ONE
10
0-0
2015
29391
McDonough M.A.,Li V.,Flashman E.,Chowdhury R.,Mohr C.,Lienard B.M.R.,Zondlo J.,Oldham N.J.,Clifton I.J.,Lewis J.,McNeill L.A.,Kurzeja R.J.,Hewitson K.S.,Yang E.,Jordan S.,Syed R.S.,Schofield C.J.
Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Proc. Natl. Acad. Sci. U.S.A.
103
9814-9819
2006
29392
Chowdhury R.,McDonough M.A.,Mecinovic J.,Loenarz C.,Flashman E.,Hewitson K.S.,Domene C.,Schofield C.J.
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
Structure
17
981-989
2009
29393
Chowdhury R.,Flashman E.,Mecinovic J.,Kramer H.B.,Kessler B.M.,Frapart Y.M.,Boucher J.L.,Clifton I.J.,McDonough M.A.,Schofield C.J.
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
J. Mol. Biol.
410
268-279
2011
29394
Ahmed S.,Ayscough A.,Barker G.R.,Canning H.E.,Davenport R.,Downham R.,Harrison D.,Jenkins K.,Kinsella N.,Livermore D.G.,Wright S.,Ivetac A.D.,Skene R.,Wilkens S.J.,Webster N.A.,Hendrick A.G.
1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.
J. Med. Chem.
60
5663-5672
2017
29395
Percy M.J.,Zhao Q.,Flores A.,Harrison C.,Lappin T.R.,Maxwell P.H.,McMullin M.F.,Lee F.S.
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.
Proc. Natl. Acad. Sci. U.S.A.
103
654-659
2006
29396
Percy M.J.,Furlow P.W.,Beer P.A.,Lappin T.R.J.,McMullin M.F.,Lee F.S.
A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove.
Blood
110
2193-2196
2007
29397
Song D.,Li L.S.,Arsenault P.R.,Tan Q.,Bigham A.W.,Heaton-Johnson K.J.,Master S.R.,Lee F.S.
Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing.
J. Biol. Chem.
289
14656-14665
2014
29398
Lorenzo F.R.,Huff C.,Myllymaeki M.,Olenchock B.,Swierczek S.,Tashi T.,Gordeuk V.,Wuren T.,Ri-Li G.,McClain D.A.,Khan T.M.,Koul P.A.,Guchhait P.,Salama M.E.,Xing J.,Semenza G.L.,Liberzon E.,Wilson A.,Simonson T.S.,Jorde L.B.,Kaelin W.G. Jr.,Koivunen P.,Prchal J.T.
A genetic mechanism for Tibetan high-altitude adaptation.
Nat. Genet.
46
951-956
2014
