Sequence of HMDH1_ARATH

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hydroxymethylglutaryl-CoA reductase (NADPH)
P14891
Arabidopsis thaliana
592
63598
Reaction
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MDLRRRPPKP PVTNNNNSNG SFRSYQPRTS DDDHRRRATT IAPPPKASDA LPLPLYLTNA
 60 VFFTLFFSVA YYLLHRWRDK IRYNTPLHVV TITELGAIIA LIASFIYLLG FFGIDFVQSF
120 ISRASGDAWD LADTIDDDDH RLVTCSPPTP IVSVAKLPNP EPIVTESLPE EDEEIVKSVI
180 DGVIPSYSLE SRLGDCKRAA SIRREALQRV TGRSIEGLPL DGFDYESILG QCCEMPVGYI
240 QIPVGIAGPL LLDGYEYSVP MATTEGCLVA STNRGCKAMF ISGGATSTVL KDGMTRAPVV
300 RFASARRASE LKFFLENPEN FDTLAVVFNR SSRFARLQSV KCTIAGKNAY VRFCCSTGDA
360 MGMNMVSKGV QNVLEYLTDD FPDMDVIGIS GNFCSDKKPA AVNWIEGRGK SVVCEAVIRG
420 EIVNKVLKTS VAALVELNML KNLAGSAVAG SLGGFNAHAS NIVSAVFIAT GQDPAQNVES
480 SQCITMMEAI NDGKDIHISV TMPSIEVGTV GGGTQLASQS ACLNLLGVKG ASTESPGMNA
540 RRLATIVAGA VLAGELSLMS AIAAGQLVRS HMKYNRSSRD ISGATTTTTT TT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
293278
Caelles C.,Ferrer A.,Balcells L.,Hegardt F.G.,Boronat A.
Isolation and structural characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Plant Mol. Biol.
13
627-638
1989
293279
Learned R.M.,Fink G.R.
3-hydroxy-3-methylglutaryl-coenzyme A reductase from Arabidopsis thaliana is structurally distinct from the yeast and animal enzymes.
Proc. Natl. Acad. Sci. U.S.A.
86
2779-2783
1989
293280
Lumbreras V.,Campos N.,Boronat A.
The use of an alternative promoter in the Arabidopsis thaliana HMG1 gene generates an mRNA that encodes a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase isoform with an extended N-terminal region.
Plant J.
8
541-549
1995
293281
Theologis A.,Ecker J.R.,Palm C.J.,Federspiel N.A.,Kaul S.,White O.,Alonso J.,Altafi H.,Araujo R.,Bowman C.L.,Brooks S.Y.,Buehler E.,Chan A.,Chao Q.,Chen H.,Cheuk R.F.,Chin C.W.,Chung M.K.,Conn L.,Conway A.B.,Conway A.R.,Creasy T.H.,Dewar K.,Dunn P.,Etgu P.,Feldblyum T.V.,Feng J.-D.,Fong B.,Fujii C.Y.,Gill J.E.,Goldsmith A.D.,Haas B.,Hansen N.F.,Hughes B.,Huizar L.,Hunter J.L.,Jenkins J.,Johnson-Hopson C.,Khan S.,Khaykin E.,Kim C.J.,Koo H.L.,Kremenetskaia I.,Kurtz D.B.,Kwan A.,Lam B.,Langin-Hooper S.,Lee A.,Lee J.M.,Lenz C.A.,Li J.H.,Li Y.-P.,Lin X.,Liu S.X.,Liu Z.A.,Luros J.S.,Maiti R.,Marziali A.,Militscher J.,Miranda M.,Nguyen M.,Nierman W.C.,Osborne B.I.,Pai G.,Peterson J.,Pham P.K.,Rizzo M.,Rooney T.,Rowley D.,Sakano H.,Salzberg S.L.,Schwartz J.R.,Shinn P.,Southwick A.M.,Sun H.,Tallon L.J.,Tambunga G.,Toriumi M.J.,Town C.D.,Utterback T.,Van Aken S.,Vaysberg M.,Vysotskaia V.S.,Walker M.,Wu D.,Yu G.,Fraser C.M.,Venter J.C.,Davis R.W.
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.
Nature
408
816-820
2000
293282
Cheng C.Y.,Krishnakumar V.,Chan A.P.,Thibaud-Nissen F.,Schobel S.,Town C.D.
Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.
Plant J.
89
789-804
2017
293283
Yamada K.,Lim J.,Dale J.M.,Chen H.,Shinn P.,Palm C.J.,Southwick A.M.,Wu H.C.,Kim C.J.,Nguyen M.,Pham P.K.,Cheuk R.F.,Karlin-Newmann G.,Liu S.X.,Lam B.,Sakano H.,Wu T.,Yu G.,Miranda M.,Quach H.L.,Tripp M.,Chang C.H.,Lee J.M.,Toriumi M.J.,Chan M.M.,Tang C.C.,Onodera C.S.,Deng J.M.,Akiyama K.,Ansari Y.,Arakawa T.,Banh J.,Banno F.,Bowser L.,Brooks S.Y.,Carninci P.,Chao Q.,Choy N.,Enju A.,Goldsmith A.D.,Gurjal M.,Hansen N.F.,Hayashizaki Y.,Johnson-Hopson C.,Hsuan V.W.,Iida K.,Karnes M.,Khan S.,Koesema E.,Ishida J.,Jiang P.X.,Jones T.,Kawai J.,Kamiya A.,Meyers C.,Nakajima M.,Narusaka M.,Seki M.,Sakurai T.,Satou M.,Tamse R.,Vaysberg M.,Wallender E.K.,Wong C.,Yamamura Y.,Yuan S.,Shinozaki K.,Davis R.W.,Theologis A.,Ecker J.R.
Empirical analysis of transcriptional activity in the Arabidopsis genome.
Science
302
842-846
2003
293284
Enjuto M.,Balcells L.,Campos N.,Caelles C.,Arro M.,Boronat A.
Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme.
Proc. Natl. Acad. Sci. U.S.A.
91
927-931
1994
293285
Dale S.,Arro M.,Becerra B.,Morrice N.G.,Boronat A.,Hardie D.G.,Ferrer A.
Bacterial expression of the catalytic domain of 3-hydroxy-3-methylglutaryl-CoA reductase (isoform HMGR1) from Arabidopsis thaliana, and its inactivation by phosphorylation at Ser577 by Brassica oleracea 3-hydroxy-3-methylglutaryl-CoA reductase kinase.
Eur. J. Biochem.
233
506-513
1995
293286
Sugden C.,Donaghy P.G.,Halford N.G.,Hardie D.G.
Two SNF1-related protein kinases from spinach leaf phosphorylate and inactivate 3-hydroxy-3-methylglutaryl-coenzyme A reductase, nitrate reductase, and sucrose phosphate synthase in vitro.
Plant Physiol.
120
257-274
1999
293287
Learned R.M.
Light suppresses 3-Hydroxy-3-methylglutaryl coenzyme A reductase gene expression in Arabidopsis thaliana.
Plant Physiol.
110
645-655
1996
293288
Learned R.M.,Connolly E.L.
Light modulates the spatial patterns of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in Arabidopsis thaliana.
Plant J.
11
499-511
1997
293289
Suzuki M.,Kamide Y.,Nagata N.,Seki H.,Ohyama K.,Kato H.,Masuda K.,Sato S.,Kato T.,Tabata S.,Yoshida S.,Muranaka T.
Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels.
Plant J.
37
750-761
2004
293290
Leivar P.,Gonzalez V.M.,Castel S.,Trelease R.N.,Lopez-Iglesias C.,Arro M.,Boronat A.,Campos N.,Ferrer A.,Fernandez-Busquets X.
Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Plant Physiol.
137
57-69
2005
293291
Ohyama K.,Suzuki M.,Masuda K.,Yoshida S.,Muranaka T.
Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis.
Chem. Pharm. Bull.
55
1518-1521
2007
293292
Suzuki M.,Nakagawa S.,Kamide Y.,Kobayashi K.,Ohyama K.,Hashinokuchi H.,Kiuchi R.,Saito K.,Muranaka T.,Nagata N.
Complete blockage of the mevalonate pathway results in male gametophyte lethality.
J. Exp. Bot.
60
2055-2064
2009
293293
Nieto B.,Fores O.,Arro M.,Ferrer A.
Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways.
Phytochemistry
70
53-59
2009
293294
Leivar P.,Antolin-Llovera M.,Ferrero S.,Closa M.,Arro M.,Ferrer A.,Boronat A.,Campos N.
Multilevel control of Arabidopsis 3-hydroxy-3-methylglutaryl coenzyme A reductase by protein phosphatase 2A.
Plant Cell
23
1494-1511
2011
293295
Doblas V.G.,Amorim-Silva V.,Pose D.,Rosado A.,Esteban A.,Arro M.,Azevedo H.,Bombarely A.,Borsani O.,Valpuesta V.,Ferrer A.,Tavares R.M.,Botella M.A.
The SUD1 gene encodes a putative E3 ubiquitin ligase and is a positive regulator of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity in Arabidopsis.
Plant Cell
25
728-743
2013
293296
Robertlee J.,Kobayashi K.,Suzuki M.,Muranaka T.
AKIN10, a representative Arabidopsis SNF1-related protein kinase 1 (SnRK1), phosphorylates and downregulates plant HMG-CoA reductase.
FEBS Lett.
591
1159-1166
2017