Sequence of DPOLA_HUMAN
EC Number:2.7.7.7
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1
Other sequences found for EC No. 2.7.7.7
General information:
Sequence
0 MAPVHGDDSL SDSGSFVSSR ARREKKSKKG RQEALERLKK AKAGEKYKYE VEDFTGVYEE
60 VDEEQYSKLV QARQDDDWIV DDDGIGYVED GREIFDDDLE DDALDADEKG KDGKARNKDK
120 RNVKKLAVTK PNNIKSMFIA CAGKKTADKA VDLSKDGLLG DILQDLNTET PQITPPPVMI
180 LKKKRSIGAS PNPFSVHTAT AVPSGKIASP VSRKEPPLTP VPLKRAEFAG DDVQVESTEE
240 EQESGAMEFE DGDFDEPMEV EEVDLEPMAA KAWDKESEPA EEVKQEADSG KGTVSYLGSF
300 LPDVSCWDID QEGDSSFSVQ EVQVDSSHLP LVKGADEEQV FHFYWLDAYE DQYNQPGVVF
360 LFGKVWIESA ETHVSCCVMV KNIERTLYFL PREMKIDLNT GKETGTPISM KDVYEEFDEK
420 IATKYKIMKF KSKPVEKNYA FEIPDVPEKS EYLEVKYSAE MPQLPQDLKG ETFSHVFGTN
480 TSSLELFLMN RKIKGPCWLE VKSPQLLNQP VSWCKVEAMA LKPDLVNVIK DVSPPPLVVM
540 AFSMKTMQNA KNHQNEIIAM AALVHHSFAL DKAAPKPPFQ SHFCVVSKPK DCIFPYAFKE
600 VIEKKNVKVE VAATERTLLG FFLAKVHKID PDIIVGHNIY GFELEVLLQR INVCKAPHWS
660 KIGRLKRSNM PKLGGRSGFG ERNATCGRMI CDVEISAKEL IRCKSYHLSE LVQQILKTER
720 VVIPMENIQN MYSESSQLLY LLEHTWKDAK FILQIMCELN VLPLALQITN IAGNIMSRTL
780 MGGRSERNEF LLLHAFYENN YIVPDKQIFR KPQQKLGDED EEIDGDTNKY KKGRKKAAYA
840 GGLVLDPKVG FYDKFILLLD FNSLYPSIIQ EFNICFTTVQ RVASEAQKVT EDGEQEQIPE
900 LPDPSLEMGI LPREIRKLVE RRKQVKQLMK QQDLNPDLIL QYDIRQKALK LTANSMYGCL
960 GFSYSRFYAK PLAALVTYKG REILMHTKEM VQKMNLEVIY GDTDSIMINT NSTNLEEVFK
1020 LGNKVKSEVN KLYKLLEIDI DGVFKSLLLL KKKKYAALVV EPTSDGNYVT KQELKGLDIV
1080 RRDWCDLAKD TGNFVIGQIL SDQSRDTIVE NIQKRLIEIG ENVLNGSVPV SQFEINKALT
1140 KDPQDYPDKK SLPHVHVALW INSQGGRKVK AGDTVSYVIC QDGSNLTASQ RAYAPEQLQK
1200 QDNLTIDTQY YLAQQIHPVV ARICEPIDGI DAVLIATWLG LDPTQFRVHH YHKDEENDAL
1260 LGGPAQLTDE EKYRDCERFK CPCPTCGTEN IYDNVFDGSG TDMEPSLYRC SNIDCKASPL
1320 TFTVQLSNKL IMDIRRFIKK YYDGWLICEE PTCRNRTRHL PLQFSRTGPL CPACMKATLQ
1380 PEYSDKSLYT QLCFYRYIFD AECALEKLTT DHEKDKLKKQ FFTPKVLQDY RKLKNTAEQF
1440 LSRSGYSEVN LSKLFAGCAV KS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
27030
Wong S.W.,Wahl A.F.,Yuan P.-M.,Arai N.,Pearson B.E.,Arai K.,Korn D.,Hunkapiller M.W.,Wang T.S.-F.
Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.
EMBO J.
7
37-47
1988
27032
Pearson B.E.,Nasheuer H.-P.,Wang T.S.-F.
Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.
Mol. Cell. Biol.
11
2081-2095
1991
27033
Hsi K.-L.,Copeland W.C.,Wang T.S.-F.
Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus.
Nucleic Acids Res.
18
6231-6237
1990
27034
Fisher P.A.,Korn D.
DNA polymerase-alpha. Purification and structural characterization of the near homogeneous enzyme from human KB cells.
J. Biol. Chem.
252
6528-6535
1977
27035
Smale S.T.,Tjian R.
T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication.
Mol. Cell. Biol.
6
4077-4087
1986
27036
Lee S.S.,Dong Q.,Wang T.S.,Lehman I.R.
Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha.
Proc. Natl. Acad. Sci. U.S.A.
92
7882-7886
1995
27037
Braun K.A.,Lao Y.,He Z.,Ingles C.J.,Wold M.S.
Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms.
Biochemistry
36
8443-8454
1997
27038
Schneider A.,Smith R.W.,Kautz A.R.,Weisshart K.,Grosse F.,Nasheuer H.P.
Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit.
J. Biol. Chem.
273
21608-21615
1998
27039
Dantzer F.,Nasheuer H.P.,Vonesch J.L.,de Murcia G.,Menissier-de Murcia J.
Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.
Nucleic Acids Res.
26
1891-1898
1998
27040
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
27041
Warren E.M.,Huang H.,Fanning E.,Chazin W.J.,Eichman B.F.
Physical interactions between Mcm10, DNA, and DNA polymerase alpha.
J. Biol. Chem.
284
24662-24672
2009
27042
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
27043
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
27044
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
27045
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
27046
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
27047
Starokadomskyy P.,Gemelli T.,Rios J.J.,Xing C.,Wang R.C.,Li H.,Pokatayev V.,Dozmorov I.,Khan S.,Miyata N.,Fraile G.,Raj P.,Xu Z.,Xu Z.,Ma L.,Lin Z.,Wang H.,Yang Y.,Ben-Amitai D.,Orenstein N.,Mussaffi H.,Baselga E.,Tadini G.,Grunebaum E.,Sarajlija A.,Krzewski K.,Wakeland E.K.,Yan N.,de la Morena M.T.,Zinn A.R.,Burstein E.
DNA polymerase-alpha regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.
Nat. Immunol.
17
495-504
2016
27048
Evanics F.,Maurmann L.,Yang W.W.,Bose R.N.
Nuclear magnetic resonance structures of the zinc finger domain of human DNA polymerase-alpha.
Biochim. Biophys. Acta
1651
163-171
2003
27049
Baranovskiy A.G.,Babayeva N.D.,Zhang Y.,Gu J.,Suwa Y.,Pavlov Y.I.,Tahirov T.H.
Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
J. Biol. Chem.
291
10006-10020
2016
27050
Van Esch H.,Colnaghi R.,Freson K.,Starokadomskyy P.,Zankl A.,Backx L.,Abramowicz I.,Outwin E.,Rohena L.,Faulkner C.,Leong G.M.,Newbury-Ecob R.A.,Challis R.C.,Ounap K.,Jaeken J.,Seuntjens E.,Devriendt K.,Burstein E.,Low K.J.,O'Driscoll M.
Defective DNA Polymerase alpha-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism.
Am. J. Hum. Genet.
104
957-967
2019
