Sequence of BRAF_HUMAN
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MAALSGGGGG GAEPGQALFN GDMEPEAGAG AGAAASSAAD PAIPEEVWNI KQMIKLTQEH
60 IEALLDKFGG EHNPPSIYLE AYEEYTSKLD ALQQREQQLL ESLGNGTDFS VSSSASMDTV
120 TSSSSSSLSV LPSSLSVFQN PTDVARSNPK SPQKPIVRVF LPNKQRTVVP ARCGVTVRDS
180 LKKALMMRGL IPECCAVYRI QDGEKKPIGW DTDISWLTGE ELHVEVLENV PLTTHNFVRK
240 TFFTLAFCDF CRKLLFQGFR CQTCGYKFHQ RCSTEVPLMC VNYDQLDLLF VSKFFEHHPI
300 PQEEASLAET ALTSGSSPSA PASDSIGPQI LTSPSPSKSI PIPQPFRPAD EDHRNQFGQR
360 DRSSSAPNVH INTIEPVNID DLIRDQGFRG DGGSTTGLSA TPPASLPGSL TNVKALQKSP
420 GPQRERKSSS SSEDRNRMKT LGRRDSSDDW EIPDGQITVG QRIGSGSFGT VYKGKWHGDV
480 AVKMLNVTAP TPQQLQAFKN EVGVLRKTRH VNILLFMGYS TKPQLAIVTQ WCEGSSLYHH
540 LHIIETKFEM IKLIDIARQT AQGMDYLHAK SIIHRDLKSN NIFLHEDLTV KIGDFGLATV
600 KSRWSGSHQF EQLSGSILWM APEVIRMQDK NPYSFQSDVY AFGIVLYELM TGQLPYSNIN
660 NRDQIIFMVG RGYLSPDLSK VRSNCPKAMK RLMAECLKKK RDERPLFPQI LASIELLARS
720 LPKIHRSASE PSLNRAGFQT EDFSLYACAS PKTPIQAGGY GAFPVH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
270949
Stephens R.M.,Sithanandam G.,Copeland T.D.,Kaplan D.R.,Rapp U.R.,Morrison D.K.
95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site.
Mol. Cell. Biol.
12
3733-3742
1992
270952
Scherer S.W.,Cheung J.,MacDonald J.R.,Osborne L.R.,Nakabayashi K.,Herbrick J.-A.,Carson A.R.,Parker-Katiraee L.,Skaug J.,Khaja R.,Zhang J.,Hudek A.K.,Li M.,Haddad M.,Duggan G.E.,Fernandez B.A.,Kanematsu E.,Gentles S.,Christopoulos C.C.,Choufani S.,Kwasnicka D.,Zheng X.H.,Lai Z.,Nusskern D.R.,Zhang Q.,Gu Z.,Lu F.,Zeesman S.,Nowaczyk M.J.,Teshima I.,Chitayat D.,Shuman C.,Weksberg R.,Zackai E.H.,Grebe T.A.,Cox S.R.,Kirkpatrick S.J.,Rahman N.,Friedman J.M.,Heng H.H.Q.,Pelicci P.G.,Lo-Coco F.,Belloni E.,Shaffer L.G.,Pober B.,Morton C.C.,Gusella J.F.,Bruns G.A.P.,Korf B.R.,Quade B.J.,Ligon A.H.,Ferguson H.,Higgins A.W.,Leach N.T.,Herrick S.R.,Lemyre E.,Farra C.G.,Kim H.-G.,Summers A.M.,Gripp K.W.,Roberts W.,Szatmari P.,Winsor E.J.T.,Grzeschik K.-H.,Teebi A.,Minassian B.A.,Kere J.,Armengol L.,Pujana M.A.,Estivill X.,Wilson M.D.,Koop B.F.,Tosi S.,Moore G.E.,Boright A.P.,Zlotorynski E.,Kerem B.,Kroisel P.M.,Petek E.,Oscier D.G.,Mould S.J.,Doehner H.,Doehner K.,Rommens J.M.,Vincent J.B.,Venter J.C.,Li P.W.,Mural R.J.,Adams M.D.,Tsui L.-C.
Human chromosome 7: DNA sequence and biology.
Science
300
767-772
2003
270953
Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
The DNA sequence of human chromosome 7.
Nature
424
157-164
2003
270954
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
270955
Eychene A.,Barnier J.V.,Apiou F.,Dutrillaux B.,Calothy G.
Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.
Oncogene
7
1657-1660
1992
270957
Sithanandam G.,Kolch W.,Duh F.-M.,Rapp U.R.
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.
Oncogene
5
1775-1780
1990
270958
Jones D.T.W.,Kocialkowski S.,Liu L.,Pearson D.M.,Backlund L.M.,Ichimura K.,Collins V.P.
Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas.
Cancer Res.
68
8673-8677
2008
270959
Ikawa S.,Fukui M.,Ueyama Y.,Tamaoki N.,Yamamoto T.,Toyoshima K.
B-raf, a new member of the raf family, is activated by DNA rearrangement.
Mol. Cell. Biol.
8
2651-2654
1988
270960
Zhang B.H.,Tang E.D.,Zhu T.,Greenberg M.E.,Vojtek A.B.,Guan K.L.
Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.
J. Biol. Chem.
276
31620-31626
2001
270961
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nat. Biotechnol.
24
1285-1292
2006
270962
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
270963
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
270964
Yasuda S.,Kai M.,Imai S.,Takeishi K.,Taketomi A.,Toyota M.,Kanoh H.,Sakane F.
Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.
J. Biol. Chem.
284
29559-29570
2009
270965
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
270966
Smith F.D.,Langeberg L.K.,Cellurale C.,Pawson T.,Morrison D.K.,Davis R.J.,Scott J.D.
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Nat. Cell Biol.
12
1242-1249
2010
270967
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
270968
Brennan D.F.,Dar A.C.,Hertz N.T.,Chao W.C.,Burlingame A.L.,Shokat K.M.,Barford D.
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
Nature
472
366-369
2011
270969
Andreu-Perez P.,Esteve-Puig R.,de Torre-Minguela C.,Lopez-Fauqued M.,Bech-Serra J.J.,Tenbaum S.,Garcia-Trevijano E.R.,Canals F.,Merlino G.,Avila M.A.,Recio J.A.
Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.
Sci. Signal.
4
0-0
2011
270970
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
270971
Hong S.W.,Jin D.H.,Shin J.S.,Moon J.H.,Na Y.S.,Jung K.A.,Kim S.M.,Kim J.C.,Kim K.P.,Hong Y.S.,Lee J.L.,Choi E.K.,Lee J.S.,Kim T.W.
Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF).
J. Biol. Chem.
287
24017-24025
2012
270972
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
270973
An L.,Jia W.,Yu Y.,Zou N.,Liang L.,Zhao Y.,Fan Y.,Cheng J.,Shi Z.,Xu G.,Li G.,Yang J.,Zhang H.
Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.
Sci. Rep.
3
2344-2344
2013
270974
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
270975
Woodford M.R.,Dunn D.M.,Blanden A.R.,Capriotti D.,Loiselle D.,Prodromou C.,Panaretou B.,Hughes P.F.,Smith A.,Ackerman W.,Haystead T.A.,Loh S.N.,Bourboulia D.,Schmidt L.S.,Marston Linehan W.,Bratslavsky G.,Mollapour M.
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
Nat. Commun.
7
12037-12037
2016
270976
Popov I.K.,Hiatt S.M.,Whalen S.,Keren B.,Ruivenkamp C.,van Haeringen A.,Chen M.J.,Cooper G.M.,Korf B.R.,Chang C.
A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway.
Front. Physiol.
10
388-388
2019
270977
Tsai J.,Lee J.T.,Wang W.,Zhang J.,Cho H.,Mamo S.,Bremer R.,Gillette S.,Kong J.,Haass N.K.,Sproesser K.,Li L.,Smalley K.S.,Fong D.,Zhu Y.L.,Marimuthu A.,Nguyen H.,Lam B.,Liu J.,Cheung I.,Rice J.,Suzuki Y.,Luu C.,Settachatgul C.,Shellooe R.,Cantwell J.,Kim S.H.,Schlessinger J.,Zhang K.Y.,West B.L.,Powell B.,Habets G.,Zhang C.,Ibrahim P.N.,Hirth P.,Artis D.R.,Herlyn M.,Bollag G.
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.
Proc. Natl. Acad. Sci. U.S.A.
105
3041-3046
2008
270978
Lavoie H.,Sahmi M.,Maisonneuve P.,Marullo S.A.,Thevakumaran N.,Jin T.,Kurinov I.,Sicheri F.,Therrien M.
MEK drives BRAF activation through allosteric control of KSR proteins.
Nature
554
549-553
2018
270979
Naoki K.,Chen T.-H.,Richards W.G.,Sugarbaker D.J.,Meyerson M.
Missense mutations of the BRAF gene in human lung adenocarcinoma.
Cancer Res.
62
7001-7003
2002
270980
Davies H.,Bignell G.R.,Cox C.,Stephens P.,Edkins S.,Clegg S.,Teague J.,Woffendin H.,Garnett M.J.,Bottomley W.,Davis N.,Dicks E.,Ewing R.,Floyd Y.,Gray K.,Hall S.,Hawes R.,Hughes J.,Kosmidou V.,Menzies A.,Mould C.,Parker A.,Stevens C.,Watt S.,Hooper S.,Wilson R.,Jayatilake H.,Gusterson B.A.,Cooper C.,Shipley J.,Hargrave D.,Pritchard-Jones K.,Maitland N.,Chenevix-Trench G.,Riggins G.J.,Bigner D.D.,Palmieri G.,Cossu A.,Flanagan A.,Nicholson A.,Ho J.W.C.,Leung S.Y.,Yuen S.T.,Weber B.L.,Seigler H.F.,Darrow T.L.,Paterson H.,Marais R.,Marshall C.J.,Wooster R.,Stratton M.R.,Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature
417
949-954
2002
270981
Rajagopalan H.,Bardelli A.,Lengauer C.,Kinzler K.W.,Vogelstein B.,Velculescu V.E.
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.
Nature
418
934-934
2002
270982
Lee J.W.,Yoo N.J.,Soung Ark W.S.,Kim S.Y.,Lee J.H.,Park J.Y.,Cho Y.G.,Kim C.J.,Ko Y.H.,Kim S.H.,Nam S.W.,Lee J.Y.,Lee S.H.
BRAF mutations in non-Hodgkin's lymphoma.
Br. J. Cancer
89
1958-1960
2003
270983
Hingorani S.R.,Jacobetz M.A.,Robertson G.P.,Herlyn M.,Tuveson D.A.
Suppression of BRAF(V599E) in human melanoma abrogates transformation.
Cancer Res.
63
5198-5202
2003
270984
Niihori T.,Aoki Y.,Narumi Y.,Neri G.,Cave H.,Verloes A.,Okamoto N.,Hennekam R.C.M.,Gillessen-Kaesbach G.,Wieczorek D.,Kavamura M.I.,Kurosawa K.,Ohashi H.,Wilson L.,Heron D.,Bonneau D.,Corona G.,Kaname T.,Naritomi K.,Baumann C.,Matsumoto N.,Kato K.,Kure S.,Matsubara Y.
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
Nat. Genet.
38
294-296
2006
270985
Sjoeblom T.,Jones S.,Wood L.D.,Parsons D.W.,Lin J.,Barber T.D.,Mandelker D.,Leary R.J.,Ptak J.,Silliman N.,Szabo S.,Buckhaults P.,Farrell C.,Meeh P.,Markowitz S.D.,Willis J.,Dawson D.,Willson J.K.V.,Gazdar A.F.,Hartigan J.,Wu L.,Liu C.,Parmigiani G.,Park B.H.,Bachman K.E.,Papadopoulos N.,Vogelstein B.,Kinzler K.W.,Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science
314
268-274
2006
270986
Rodriguez-Viciana P.,Tetsu O.,Tidyman W.E.,Estep A.L.,Conger B.A.,Cruz M.S.,McCormick F.,Rauen K.A.
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.
Science
311
1287-1290
2006
270987
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
270988
Schulz A.L.,Albrecht B.,Arici C.,van der Burgt I.,Buske A.,Gillessen-Kaesbach G.,Heller R.,Horn D.,Hubner C.A.,Korenke G.C.,Konig R.,Kress W.,Kruger G.,Meinecke P.,Mucke J.,Plecko B.,Rossier E.,Schinzel A.,Schulze A.,Seemanova E.,Seidel H.,Spranger S.,Tuysuz B.,Uhrig S.,Wieczorek D.,Kutsche K.,Zenker M.
Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.
Clin. Genet.
73
62-70
2008
270989
Sarkozy A.,Carta C.,Moretti S.,Zampino G.,Digilio M.C.,Pantaleoni F.,Scioletti A.P.,Esposito G.,Cordeddu V.,Lepri F.,Petrangeli V.,Dentici M.L.,Mancini G.M.,Selicorni A.,Rossi C.,Mazzanti L.,Marino B.,Ferrero G.B.,Silengo M.C.,Memo L.,Stanzial F.,Faravelli F.,Stuppia L.,Puxeddu E.,Gelb B.D.,Dallapiccola B.,Tartaglia M.
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
Hum. Mutat.
30
695-702
2009
270990
Palles C.,Cazier J.B.,Howarth K.M.,Domingo E.,Jones A.M.,Broderick P.,Kemp Z.,Spain S.L.,Guarino Almeida E.,Salguero I.,Sherborne A.,Chubb D.,Carvajal-Carmona L.G.,Ma Y.,Kaur K.,Dobbins S.,Barclay E.,Gorman M.,Martin L.,Kovac M.B.,Humphray S.,Lucassen A.,Holmes C.C.,Bentley D.,Donnelly P.,Taylor J.,Petridis C.,Roylance R.,Sawyer E.J.,Kerr D.J.,Clark S.,Grimes J.,Kearsey S.E.,Thomas H.J.,McVean G.,Houlston R.S.,Tomlinson I.
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Nat. Genet.
45
136-144
2013
270991
D'mello S.A.,Flanagan J.U.,Green T.N.,Leung E.Y.,Askarian-Amiri M.E.,Joseph W.R.,McCrystal M.R.,Isaacs R.J.,Shaw J.H.,Furneaux C.E.,During M.J.,Finlay G.J.,Baguley B.C.,Kalev-Zylinska M.L.
Evidence that GRIN2A mutations in melanoma correlate with decreased survival.
Front. Oncol.
3
333-333
2014
