Sequence of BACE2_HUMAN
EC Number:3.4.23.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Other sequences found for EC No. 3.4.23.45
General information:
Sequence
0 MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG TPAERHADGL
60 ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG
120 TPHSYIDTYF DTERSSTYRS KGFDVTVKYT QGSWTGFVGE DLVTIPKGFN TSFLVNIATI
180 FESENFFLPG IKWNGILGLA YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA
240 GSGTNGGSLV LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA
300 IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET PWSYFPKISI
360 YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP STNALVIGAT VMEGFYVIFD
420 RAQKRVGFAA SPCAEIAGAA VSEISGPFST EDVASNCVPA QSLSEPILWI VSYALMSVCG
480 AILLVLIVLL LLPFRCQRRP RDPEVVNDES SLVRHRWK
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
269276
Yan R.,Bienkowski M.J.,Shuck M.E.,Miao H.,Tory M.C.,Pauley A.M.,Brashier J.R.,Stratman N.C.,Mathews W.R.,Buhl A.E.,Carter D.B.,Tomasselli A.G.,Parodi L.A.,Heinrikson R.L.,Gurney M.E.
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Nature
402
533-537
1999
269277
Xin H.,Stephans J.C.,Duan X.,Harrowe G.,Kim E.,Grieshammer U.,Kingsley C.,Giese K.
Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines.
Biochim. Biophys. Acta
1501
125-137
2000
269278
Solans A.,Estivill X.,de La Luna S.
A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase.
Cytogenet. Cell Genet.
89
177-184
2000
269279
Acquati F.,Accarino M.P.,Nucci C.,Fumagalli P.,Jovine L.,Ottolenghi S.,Taramelli R.
The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region.
FEBS Lett.
468
59-64
2000
269280
Bennett B.D.,Babu-Khan S.,Loeloff R.,Louis J.-C.,Curran E.,Citron M.,Vassar R.
Expression analysis of BACE2 in brain and peripheral tissues.
J. Biol. Chem.
275
20647-20651
2000
269281
Hussain I.,Powell D.J.,Howlett D.R.,Chapman G.A.,Gilmour L.,Murdock P.R.,Tew D.G.,Meek T.D.,Chapman C.,Schneider K.,Ratcliffe S.J.,Tattersall D.,Testa T.T.,Southan C.,Ryan D.M.,Simmons D.L.,Walsh F.S.,Dingwall C.,Christie G.
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
Mol. Cell. Neurosci.
16
609-619
2000
269282
Lin X.,Koelsch G.,Wu S.,Downs D.,Dashti A.,Tang J.
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
Proc. Natl. Acad. Sci. U.S.A.
97
1456-1460
2000
269284
Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome Res.
13
2265-2270
2003
269285
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
269286
Hattori M.,Fujiyama A.,Taylor T.D.,Watanabe H.,Yada T.,Park H.-S.,Toyoda A.,Ishii K.,Totoki Y.,Choi D.-K.,Groner Y.,Soeda E.,Ohki M.,Takagi T.,Sakaki Y.,Taudien S.,Blechschmidt K.,Polley A.,Menzel U.,Delabar J.,Kumpf K.,Lehmann R.,Patterson D.,Reichwald K.,Rump A.,Schillhabel M.,Schudy A.,Zimmermann W.,Rosenthal A.,Kudoh J.,Shibuya K.,Kawasaki K.,Asakawa S.,Shintani A.,Sasaki T.,Nagamine K.,Mitsuyama S.,Antonarakis S.E.,Minoshima S.,Shimizu N.,Nordsiek G.,Hornischer K.,Brandt P.,Scharfe M.,Schoen O.,Desario A.,Reichelt J.,Kauer G.,Bloecker H.,Ramser J.,Beck A.,Klages S.,Hennig S.,Riesselmann L.,Dagand E.,Wehrmeyer S.,Borzym K.,Gardiner K.,Nizetic D.,Francis F.,Lehrach H.,Reinhardt R.,Yaspo M.-L.
The DNA sequence of human chromosome 21.
Nature
405
311-319
2000
269288
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
269289
Sun X.,Wang Y.,Qing H.,Christensen M.A.,Liu Y.,Zhou W.,Tong Y.,Xiao C.,Huang Y.,Zhang S.,Liu X.,Song W.
Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
FASEB J.
19
739-749
2005
269290
Yan R.,Munzner J.B.,Shuck M.E.,Bienkowski M.J.
BACE2 functions as an alternative alpha-secretase in cells.
J. Biol. Chem.
276
34019-34027
2001
269291
Sun X.,He G.,Song W.
BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.
FASEB J.
20
1369-1376
2006
269292
Ostermann N.,Eder J.,Eidhoff U.,Zink F.,Hassiepen U.,Worpenberg S.,Maibaum J.,Simic O.,Hommel U.,Gerhartz B.
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.
J. Mol. Biol.
355
249-261
2006
269293
Hussain I.,Christie G.,Schneider K.,Moore S.,Dingwall C.
Prodomain processing of Asp1 (BACE2) is autocatalytic.
J. Biol. Chem.
276
23322-23328
2001
269294
Murayama K.S.,Kametani F.,Saito S.,Kume H.,Akiyama H.,Araki W.
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
Eur. J. Neurosci.
24
1237-1244
2006
269295
Esterhazy D.,Stuetzer I.,Wang H.,Rechsteiner M.P.,Beauchamp J.,Doebeli H.,Hilpert H.,Matile H.,Prummer M.,Schmidt A.,Lieske N.,Boehm B.,Marselli L.,Bosco D.,Kerr-Conte J.,Aebersold R.,Spinas G.A.,Moch H.,Migliorini C.,Stoffel M.
Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass.
Cell Metab.
14
365-377
2011