Sequence of CP7A1_RAT

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cholesterol 7alpha-monooxygenase
P18125
Rattus norvegicus
503
56883
Reaction
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MMTISLIWGI AVLVSCCIWF IVGIRRRKAG EPPLENGLIP YLGCALKFGS NPLEFLRANQ
 60 RKHGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HYTTSAKAFG HRSIDPNDGN
120 TTENINNTFT KTLQGDALCS LSEAMMQNLQ SVMRPPGLPK SKSNAWVTEG MYAFCYRVMF
180 EAGYLTLFGR DISKTDTQKA LILNNLDNFK QFDQVFPALV AGLPIHLFKT AHKAREKLAE
240 GLKHKNLCVR DQVSELIRLR MFLNDTLSTF DDMEKAKTHL AILWASQANT IPATFWSLFQ
300 MIRSPEAMKA ASEEVSGALQ SAGQELSSGG SAIYLDQVQL NDLPVLDSII KEALRLSSAS
360 LNIRTAKEDF TLHLEDGSYN IRKDDMIALY PQLMHLDPEI YPDPLTFKYD RYLDESGKAK
420 TTFYSNGNKL KCFYMPFGSG ATICPGRLFA VQEIKQFLIL MLSCFELEFV ESQVKCPPLD
480 QSRAGLGILP PLHDIEFKYK LKH
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
269320
Li Y.C.,Wang D.P.,Chiang J.Y.L.
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.
J. Biol. Chem.
265
12012-12019
1990
269321
Jelinek D.F.,Andersson S.,Slaughter C.A.,Russell D.W.
Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.
J. Biol. Chem.
265
8190-8197
1990
269322
Noshiro M.,Nishimoto M.,Morohashi K.,Okuda K.
Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression.
FEBS Lett.
257
97-100
1989
269323
Noshiro M.,Nishimoto M.,Okuda K.
Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm.
J. Biol. Chem.
265
10036-10041
1990
269324
Nishimoto M.,Gotoh O.,Okuda K.,Noshiro M.
Structural analysis of the gene encoding rat cholesterol alpha-hydroxylase, the key enzyme for bile acid biosynthesis.
J. Biol. Chem.
266
6467-6471
1991
269325
Chiang J.Y.,Stroup D.
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
J. Biol. Chem.
269
17502-17507
1994
269326
Jelinek D.F.,Russell D.W.
Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase.
Biochemistry
29
7781-7785
1990
269327
Chiang J.Y.,Yang T.P.,Wang D.P.
Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.
Biochim. Biophys. Acta
1132
337-339
1992
269328
Gupta S.,Stravitz R.T.,Dent P.,Hylemon P.B.
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.
J. Biol. Chem.
276
15816-15822
2001