Sequence of CP7A1_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cholesterol 7alpha-monooxygenase
P22680
Homo sapiens
504
57661
Reaction
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MMTTSLIWGI AIAACCCLWL ILGIRRRQTG EPPLENGLIP YLGCALQFGA NPLEFLRANQ
 60 RKHGHVFTCK LMGKYVHFIT NPLSYHKVLC HGKYFDWKKF HFATSAKAFG HRSIDPMDGN
120 TTENINDTFI KTLQGHALNS LTESMMENLQ RIMRPPVSSN SKTAAWVTEG MYSFCYRVMF
180 EAGYLTIFGR DLTRRDTQKA HILNNLDNFK QFDKVFPALV AGLPIHMFRT AHNAREKLAE
240 SLRHENLQKR ESISELISLR MFLNDTLSTF DDLEKAKTHL VVLWASQANT IPATFWSLFQ
300 MIRNPEAMKA ATEEVKRTLE NAGQKVSLEG NPICLSQAEL NDLPVLDSII KESLRLSSAS
360 LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDENGKTK
420 TTFYCNGLKL KYYYMPFGSG ATICPGRLFA IHEIKQFLIL MLSYFELELI EGQAKCPPLD
480 QSRAGLGILP PLNDIEFKYK FKHL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
269300
Nishimoto M.,Noshiro M.,Okuda K.
Structure of the gene encoding human liver cholesterol 7 alpha-hydroxylase.
Biochim. Biophys. Acta
1172
147-150
1993
269301
Noshiro M.,Okuda K.
Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.
FEBS Lett.
268
137-140
1990
269302
Karam W.G.,Chiang J.Y.
Polymorphisms of human cholesterol 7 alpha-hydroxylase.
Biochem. Biophys. Res. Commun.
185
588-595
1992
269303
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
269304
Wang D.P.,Chiang J.Y.
Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7).
Genomics
20
320-323
1994
269305
Molowa D.T.,Chen W.S.,Cimis G.M.,Tan C.P.
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene.
Biochemistry
31
2539-2544
1992
269306
Norlin M.,Toll A.,Bjoerkhem I.,Wikvall K.
24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).
J. Lipid Res.
41
1629-1639
2000
269307
Bodin K.,Andersson U.,Rystedt E.,Ellis E.,Norlin M.,Pikuleva I.,Eggertsen G.,Bjoerkhem I.,Diczfalusy U.
Metabolism of 4 beta -hydroxycholesterol in humans.
J. Biol. Chem.
277
31534-31540
2002
269308
Abrahamsson A.,Gustafsson U.,Ellis E.,Nilsson L.M.,Sahlin S.,Bjorkhem I.,Einarsson C.
Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1.
Biochem. Biophys. Res. Commun.
330
395-399
2005
269309
Li T.,Chanda D.,Zhang Y.,Choi H.S.,Chiang J.Y.
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
J. Lipid Res.
51
832-842
2010
269310
Shinkyo R.,Xu L.,Tallman K.A.,Cheng Q.,Porter N.A.,Guengerich F.P.
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.
J. Biol. Chem.
286
33021-33028
2011
269312
Saito S.,Iida A.,Sekine A.,Kawauchi S.,Higuchi S.,Ogawa C.,Nakamura Y.
Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.
J. Hum. Genet.
48
249-270
2003