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Sequence of DCE1_HUMAN

EC Number:4.1.1.15

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
glutamate decarboxylase
Q99259
Homo sapiens
594
66897
Reaction
L-glutamate = 4-aminobutanoate + CO2
Other sequences found for EC No. 4.1.1.15

General information:

Sequence
show sequence in fasta format
  0 MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK
 60 SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV
120 VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV
180 RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS
240 SKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS HYSIKKAGAA
300 LGFGTDNVIL IKCNERGKII PADFEAKILE AKQKGYVPFY VNATAGTTVY GAFDPIQEIA
360 DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT WNPHKMMGVL LQCSAILVKE
420 KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI
480 NKCLELAEYL YAKIKNREEF EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP
540 KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
24103
Bu D.-F.,Erlander M.G.,Hitz B.C.,Tillakaratne N.J.,Kaufman D.L.,Wagner-Mcpherson C.B.,Evans G.A.,Tobin A.J.
Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.
Proc. Natl. Acad. Sci. U.S.A.
89
2115-2119
1992
24104
Bu D.-F.,Tobin A.J.
The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD.
Genomics
21
222-228
1994
24105
Kelly C.D.,Carter N.D.,Johnstone A.P.,Nussey S.S.
Cloning of large isoform of human brain glutamic acid decarboxylase.
Lancet
338
1468-1469
1991
24106
Kelly C.D.,Edwards Y.,Johnstone A.P.,Harfst E.,Nogradi A.,Nussey S.S.,Povey S.,Carter N.D.
Nucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase.
Ann. Hum. Genet.
56
255-265
1992
24107
Yamashita K.,Cram D.S.,Harrison L.C.
Molecular cloning of full-length glutamic acid decarboxylase 67 from human pancreas and islets.
Biochem. Biophys. Res. Commun.
192
1347-1352
1993
24108
Kawasaki E.,Moriuchi R.,Watanabe M.,Saitoh K.,Brunicardi F.C.,Watt P.C.,Yamaguchi T.,Mullen Y.,Akazawa S.,Miyamoto T.
Cloning and expression of large isoform of glutamic acid decarboxylase from human pancreatic islet.
Biochem. Biophys. Res. Commun.
192
1353-1359
1993
24110
Chessler S.D.,Lernmark A.
Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues.
J. Biol. Chem.
275
5188-5192
2000
24112
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
24114
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
24115
Cram D.S.,Barnett L.D.,Joseph J.L.,Harrison L.C.
Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets.
Biochem. Biophys. Res. Commun.
176
1239-1244
1991
24116
Persson H.,Pelto-Huikko M.,Metsis M.,Soeder O.,Brene S.,Skog S.,Hoekfelt T.,Ritzen E.M.
Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells.
Mol. Cell. Biol.
10
4701-4711
1990
24117
Chatron N.,Becker F.,Morsy H.,Schmidts M.,Hardies K.,Tuysuz B.,Roselli S.,Najafi M.,Alkaya D.U.,Ashrafzadeh F.,Nabil A.,Omar T.,Maroofian R.,Karimiani E.G.,Hussien H.,Kok F.,Ramos L.,Gunes N.,Bilguvar K.,Labalme A.,Alix E.,Sanlaville D.,de Bellesciz e J.,Poulat A.L.,Moslemi A.R.,Lerche H.,May P.,Lesca G.,Weckhuysen S.,Tajsharghi H.
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.
Brain
143
1447-1461
2020
24118
Fenalti G.,Law R.H.P.,Buckle A.M.,Langendorf C.,Tuck K.,Rosado C.J.,Faux N.G.,Mahmood K.,Hampe C.S.,Banga J.P.,Wilce M.,Schmidberger J.,Rossjohn J.,El-Kabbani O.,Pike R.N.,Smith A.I.,Mackay I.R.,Rowley M.J.,Whisstock J.C.
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat. Struct. Mol. Biol.
14
280-286
2007
24119
Langendorf C.G.,Tuck K.L.,Key T.L.,Fenalti G.,Pike R.N.,Rosado C.J.,Wong A.S.,Buckle A.M.,Law R.H.,Whisstock J.C.
Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates.
Biosci. Rep.
33
137-144
2013
24120
Lynex C.N.,Carr I.M.,Leek J.P.,Achuthan R.,Mitchell S.,Maher E.R.,Woods C.G.,Bonthon D.T.,Markham A.F.
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
BMC Neurol.
4
20-20
2004
24121
Morgan N.V.,Yngvadottir B.,O'Driscoll M.,Clark G.R.,Walsh D.,Martin E.,Tee L.,Reid E.,Titheradge H.L.,Maher E.R.
Evidence that autosomal recessive spastic cerebral palsy-1 (CPSQ1) is caused by a missense variant in HPDL.
Brain Commun.
3
0-0
2021