Sequence of DAPK2_HUMAN
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MFQASMRSPN MEPFKQQKVE DFYDIGEELG SGQFAIVKKC REKSTGLEYA AKFIKKRQSR
60 ASRRGVSREE IEREVSILRQ VLHHNVITLH DVYENRTDVV LILELVSGGE LFDFLAQKES
120 LSEEEATSFI KQILDGVNYL HTKKIAHFDL KPENIMLLDK NIPIPHIKLI DFGLAHEIED
180 GVEFKNIFGT PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANIT
240 AVSYDFDEEF FSQTSELAKD FIRKLLVKET RKRLTIQEAL RHPWITPVDN QQAMVRRESV
300 VNLENFRKQY VRRRWKLSFS IVSLCNHLTR SLMKKVHLRP DEDLRNCESD TEEDIARRKA
360 LHPRRRSSTS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
23891
Kawai T.,Nomura F.,Hoshino K.,Copeland N.G.,Gilbert D.J.,Jenkins N.A.,Akira S.
Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Oncogene
18
3471-3480
1999
23892
Inbal B.,Shani G.,Cohen O.,Kissil J.L.,Kimchi A.
Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.
Mol. Cell. Biol.
20
1044-1054
2000
23893
Shoval Y.,Berissi H.,Kimchi A.,Pietrokovski S.
New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.
PLoS ONE
6
0-0
2011
23894
Zody M.C.,Garber M.,Sharpe T.,Young S.K.,Rowen L.,O'Neill K.,Whittaker C.A.,Kamal M.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Kodira C.D.,Madan A.,Qin S.,Yang X.,Abbasi N.,Abouelleil A.,Arachchi H.M.,Baradarani L.,Birditt B.,Bloom S.,Bloom T.,Borowsky M.L.,Burke J.,Butler J.,Cook A.,DeArellano K.,DeCaprio D.,Dorris L. III,Dors M.,Eichler E.E.,Engels R.,Fahey J.,Fleetwood P.,Friedman C.,Gearin G.,Hall J.L.,Hensley G.,Johnson E.,Jones C.,Kamat A.,Kaur A.,Locke D.P.,Madan A.,Munson G.,Jaffe D.B.,Lui A.,Macdonald P.,Mauceli E.,Naylor J.W.,Nesbitt R.,Nicol R.,O'Leary S.B.,Ratcliffe A.,Rounsley S.,She X.,Sneddon K.M.B.,Stewart S.,Sougnez C.,Stone S.M.,Topham K.,Vincent D.,Wang S.,Zimmer A.R.,Birren B.W.,Hood L.,Lander E.S.,Nusbaum C.
Analysis of the DNA sequence and duplication history of human chromosome 15.
Nature
440
671-675
2006
23895
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
23896
Shani G.,Henis-Korenblit S.,Jona G.,Gileadi O.,Eisenstein M.,Ziv T.,Admon A.,Kimchi A.
Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding.
EMBO J.
20
1099-1113
2001
23897
Shohat G.,Shani G.,Eisenstein M.,Kimchi A.
The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases.
Biochim. Biophys. Acta
1600
45-50
2002
23898
Inbal B.,Bialik S.,Sabanay I.,Shani G.,Kimchi A.
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.
J. Cell Biol.
157
455-468
2002
23899
Bialik S.,Kimchi A.
The death-associated protein kinases: structure, function, and beyond.
Annu. Rev. Biochem.
75
189-210
2006
23900
Rizzi M.,Tschan M.P.,Britschgi C.,Britschgi A.,Huegli B.,Grob T.J.,Leupin N.,Mueller B.U.,Simon H.U.,Ziemiecki A.,Torbett B.E.,Fey M.F.,Tobler A.
The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells.
J. Leukoc. Biol.
81
1599-1608
2007
23901
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
23902
Li H.,Ray G.,Yoo B.H.,Erdogan M.,Rosen K.V.
Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells.
J. Biol. Chem.
284
2012-2022
2009
23903
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
23904
Geering B.,Stoeckle C.,Rozman S.,Oberson K.,Benarafa C.,Simon H.U.
DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants.
J. Leukoc. Biol.
95
293-303
2014
23905
Yuasa K.,Ota R.,Matsuda S.,Isshiki K.,Inoue M.,Tsuji A.
Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.
Biochem. Biophys. Res. Commun.
464
70-75
2015
23906
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
