Sequence of STK24_HUMAN
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MDSRAQLWGL ALNKRRATLP HPGGSTNLKA DPEELFTKLE KIGKGSFGEV FKGIDNRTQK
60 VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS YLKDTKLWII MEYLGGGSAL
120 DLLEPGPLDE TQIATILREI LKGLDYLHSE KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ
180 LTDTQIKRNT FVGTPFWMAP EVIKQSAYDS KADIWSLGIT AIELARGEPP HSELHPMKVL
240 FLIPKNNPPT LEGNYSKPLK EFVEACLNKE PSFRPTAKEL LKHKFILRNA KKTSYLTELI
300 DRYKRWKAEQ SHDDSSSEDS DAETDGQASG GSDSGDWIFT IREKDPKNLE NGALQPSDLD
360 RNKMKDIPKR PFSQCLSTII SPLFAELKEK SQACGGNLGS IEELRGAIYL AEEACPGISD
420 TMVAQLVQRL QRYSLSGGGT SSH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
235789
Schinkmann K.,Blenis J.
Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.
J. Biol. Chem.
272
28695-28703
1997
235790
Zhou T.-H.,Ling K.,Guo J.,Zhou H.,Wu Y.-L.,Jing Q.,Ma L.,Pei G.
Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.
J. Biol. Chem.
275
2513-2519
2000
235791
Dunham A.,Matthews L.H.,Burton J.,Ashurst J.L.,Howe K.L.,Ashcroft K.J.,Beare D.M.,Burford D.C.,Hunt S.E.,Griffiths-Jones S.,Jones M.C.,Keenan S.J.,Oliver K.,Scott C.E.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews D.T.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Bannerjee R.,Barlow K.F.,Bates K.,Beasley H.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burrill W.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.E.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.C.,Cobley V.,Collins J.E.,Corby N.,Coville G.J.,Deloukas P.,Dhami P.,Dunham I.,Dunn M.,Earthrowl M.E.,Ellington A.G.,Faulkner L.,Frankish A.G.,Frankland J.,French L.,Garner P.,Garnett J.,Gilbert J.G.R.,Gilson C.J.,Ghori J.,Grafham D.V.,Gribble S.M.,Griffiths C.,Hall R.E.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Howden P.J.,Huckle E.J.,Hunt P.J.,Hunt A.R.,Johnson C.,Johnson D.,Kay M.,Kimberley A.M.,King A.,Laird G.K.,Langford C.J.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Lloyd C.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,McLaren S.J.,McMurray A.,Milne S.,Moore M.J.F.,Nickerson T.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.M.,Rice C.M.,Searle S.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Steward C.A.,Sycamore N.,Tester J.,Thomas D.W.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Wilming L.,Wray P.W.,Wright M.W.,Young L.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Beck S.,Bentley D.R.,Rogers J.,Ross M.T.
The DNA sequence and analysis of human chromosome 13.
Nature
428
522-528
2004
235793
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
235794
Huang C.Y.,Wu Y.M.,Hsu C.Y.,Lee W.S.,Lai M.D.,Lu T.J.,Huang C.L.,Leu T.H.,Shih H.M.,Fang H.I.,Robinson D.R.,Kung H.J.,Yuan C.J.
Caspase activation of mammalian sterile 20-like kinase 3 (Mst3).
J. Biol. Chem.
277
34367-34374
2002
235795
Lee W.S.,Hsu C.Y.,Wang P.L.,Huang C.Y.,Chang C.H.,Yuan C.J.
Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3.
FEBS Lett.
572
41-45
2004
235796
Lu T.J.,Huang C.Y.,Yuan C.J.,Lee Y.C.,Leu T.H.,Chang W.C.,Lu T.L.,Jeng W.Y.,Lai M.D.
Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3.
J. Inorg. Biochem.
99
1306-1313
2005
235797
Stegert M.R.,Hergovich A.,Tamaskovic R.,Bichsel S.J.,Hemmings B.A.
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.
Mol. Cell. Biol.
25
11019-11029
2005
235798
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
235799
Lu T.J.,Lai W.Y.,Huang C.Y.,Hsieh W.J.,Yu J.S.,Hsieh Y.J.,Chang W.T.,Leu T.H.,Chang W.C.,Chuang W.J.,Tang M.J.,Chen T.Y.,Lu T.L.,Lai M.D.
Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST.
J. Biol. Chem.
281
38405-38417
2006
235800
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
235801
Chen C.B.,Ng J.K.,Choo P.H.,Wu W.,Porter A.G.
Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation.
Biosci. Rep.
29
405-415
2009
235802
Goudreault M.,D'Ambrosio L.M.,Kean M.J.,Mullin M.J.,Larsen B.G.,Sanchez A.,Chaudhry S.,Chen G.I.,Sicheri F.,Nesvizhskii A.I.,Aebersold R.,Raught B.,Gingras A.C.
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
Mol. Cell. Proteomics
8
157-171
2009
235803
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
235804
Lorber B.,Howe M.L.,Benowitz L.I.,Irwin N.
Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways.
Nat. Neurosci.
12
1407-1414
2009
235805
Lin C.Y.,Wu H.Y.,Wang P.L.,Yuan C.J.
Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway.
Int. J. Biochem. Cell Biol.
42
98-105
2010
235806
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
235807
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
235808
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
235809
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
235810
Mardakheh F.K.,Self A.,Marshall C.J.
RHO binding to FAM65A regulates Golgi reorientation during cell migration.
J. Cell Sci.
129
4466-4479
2016
235811
Ko T.P.,Jeng W.Y.,Liu C.I.,Lai M.D.,Wu C.L.,Chang W.J.,Shr H.L.,Lu T.J.,Wang A.H.
Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr. D
66
145-154
2010
235812
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
