Sequence of SPEB_STRPY
EC Number:3.4.22.10
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
preferential cleavage with hydrophobic residues at P2, P1 and P1'
Other sequences found for EC No. 3.4.22.10
General information:
Sequence
0 MNKKKLGIRL LSLLALGGFV LANPVFADQN FARNEKEAKD SAITFIQKSA AIKAGARSAE
60 DIKLDKVNLG GELSGSNMYV YNISTGGFVI VSGDKRSPEI LGYSTSGSFD ANGKENIASF
120 MESYVEQIKE NKKLDTTYAG TAEIKQPVVK SLLDSKGIHY NQGNPYNLLT PVIEKVKPGE
180 QSFVGQHAAT GCVATATAQI MKYHNYPNKG LKDYTYTLSS NNPYFNHPKN LFAAISTRQY
240 NWNNILPTYS GRESNVQKMA ISELMADVGI SVDMDYGPSS GSAGSSRVQR ALKENFGYNQ
300 SVHQINRSDF SKQDWEAQID KELSQNQPVY YQGVGKVGGH AFVIDGADGR NFYHVNWGWG
360 GVSDGFFRLD ALNPSALGTG GGAGGFNGYQ SAVVGIKP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
233818
Hauser A.R.,Schlievert P.M.
Nucleotide sequence of the streptococcal pyrogenic exotoxin type B gene and relationship between the toxin and the streptococcal proteinase precursor.
J. Bacteriol.
172
4536-4542
1990
233819
Kapur V.,Topouzis S.,Majesky M.W.,Li L.L.,Hamrick M.R.,Hamill R.J.,Patti J.M.,Musser J.M.
A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin.
Microb. Pathog.
15
327-346
1993
233822
Tai J.Y.,Kortt A.A.,Liu T.-Y.,Elliott S.D.
Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain.
J. Biol. Chem.
251
1955-1959
1976
233823
Lo S.S.,Fraser B.A.,Liu T.-Y.
The mixed disulfide in the zymogen of streptococcal proteinase. Characterization and implication for its biosynthesis.
J. Biol. Chem.
259
11041-11045
1984
233824
Kuo C.-F.,Wu J.-J.,Tsai P.-J.,Kao F.-J.,Lei H.-Y.,Lin M.T.,Lin Y.-S.
Streptococcal pyrogenic exotoxin B induces apoptosis and reduces phagocytic activity in U937 cells.
Infect. Immun.
67
126-130
1999
233825
Kagawa T.F.,Cooney J.C.,Baker H.M.,McSweeney S.,Liu M.,Gubba S.,Musser J.M.,Baker E.N.
Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
Proc. Natl. Acad. Sci. U.S.A.
97
2235-2240
2000
233826
Olsen J.G.,Dagil R.,Niclasen L.M.,Sorensen O.E.,Kragelund B.B.
Structure of the mature Streptococcal cysteine protease exotoxin mSpeB in its active dimeric form.
J. Mol. Biol.
393
693-703
2009
