Sequence of SOMT3_PAPSO
EC Number:2.1.1.117
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine
Other sequences found for EC No. 2.1.1.117
General information:
Sequence
0 MEVVSKIDQE NQAKIWKQIF GFAESLVLKC AVQLEIAETL HNNVKPMSLS ELASKLPAQP
60 VNEDRLYRIL HFLVHMKLFN KDATTQKYSL APPAKYLLKG WEKSMVPSIL SVTDKDFTAP
120 WNHLGDGLTG NCNAFEKALG KGIRVYMREN PEKDQLFNEG MACDTRLFAS ALVNECKSIF
180 SDGINTLAGV GRGTGTAVKA ISKAFPDIKC TIHDLPEVTS KNSKIPRDVF KSVPSADAIF
240 MKSILHEWND EECIQILKRC KEAIPKGGKV IIADVVIDMD STHPYSKSRL AMDLAMMLHT
300 GGKERTEEDW KKLIDAAGFA SCKITKLSAL QSVIEAYPH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
233254
Dang T.T.,Facchini P.J.
Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy.
Plant Physiol.
159
618-631
2012
233255
Winzer T.,Gazda V.,He Z.,Kaminski F.,Kern M.,Larson T.R.,Li Y.,Meade F.,Teodor R.,Vaistij F.E.,Walker C.,Bowser T.A.,Graham I.A.
A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.
Science
336
1704-1708
2012
233256
Park M.R.,Chen X.,Lang D.E.,Ng K.K.S.,Facchini P.J.
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
Plant J.
95
252-267
2018
233257
Li Y.,Smolke C.D.
Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
Nat. Commun.
7
12137-12137
2016
233258
Li Y.,Li S.,Thodey K.,Trenchard I.,Cravens A.,Smolke C.D.
Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
Proc. Natl. Acad. Sci. U.S.A.
115
0-0
2018
