Sequence of POL_MLVMS
EC Number:3.1.26.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Endonucleolytic cleavage to a 5'-phosphomonoester
Other sequences found for EC No. 3.1.26.4
General information:
Sequence
0 MGQTVTTPLS LTLGHWKDVE RIAHNQSVDV KKRRWVTFCS AEWPTFNVGW PRDGTFNRDL
60 ITQVKIKVFS PGPHGHPDQV PYIVTWEALA FDPPPWVKPF VHPKPPPPLP PSAPSLPLEP
120 PRSTPPRSSL YPALTPSLGA KPKPQVLSDS GGPLIDLLTE DPPPYRDPRP PPSDRDGNGG
180 EATPAGEAPD PSPMASRLRG RREPPVADST TSQAFPLRAG GNGQLQYWPF SSSDLYNWKN
240 NNPSFSEDPG KLTALIESVL ITHQPTWDDC QQLLGTLLTG EEKQRVLLEA RKAVRGDDGR
300 PTQLPNEVDA AFPLERPDWD YTTQAGRNHL VHYRQLLLAG LQNAGRSPTN LAKVKGITQG
360 PNESPSAFLE RLKEAYRRYT PYDPEDPGQE TNVSMSFIWQ SAPDIGRKLE RLEDLKNKTL
420 GDLVREAEKI FNKRETPEER EERIRRETEE KEERRRTEDE QKEKERDRRR HREMSKLLAT
480 VVSGQKQDRQ GGERRRSQLD RDQCAYCKEK GHWAKDCPKK PRGPRGPRPQ TSLLTLDDQG
540 GQGQEPPPEP RITLKVGGQP VTFLVDTGAQ HSVLTQNPGP LSDKSAWVQG ATGGKRYRWT
600 TDRKVHLATG KVTHSFLHVP DCPYPLLGRD LLTKLKAQIH FEGSGAQVMG PMGQPLQVLT
660 LNIEDEHRLH ETSKEPDVSL GSTWLSDFPQ AWAETGGMGL AVRQAPLIIP LKATSTPVSI
720 KQYPMSQEAR LGIKPHIQRL LDQGILVPCQ SPWNTPLLPV KKPGTNDYRP VQDLREVNKR
780 VEDIHPTVPN PYNLLSGLPP SHQWYTVLDL KDAFFCLRLH PTSQPLFAFE WRDPEMGISG
840 QLTWTRLPQG FKNSPTLFDE ALHRDLADFR IQHPDLILLQ YVDDLLLAAT SELDCQQGTR
900 ALLQTLGNLG YRASAKKAQI CQKQVKYLGY LLKEGQRWLT EARKETVMGQ PTPKTPRQLR
960 EFLGTAGFCR LWIPGFAEMA APLYPLTKTG TLFNWGPDQQ KAYQEIKQAL LTAPALGLPD
1020 LTKPFELFVD EKQGYAKGVL TQKLGPWRRP VAYLSKKLDP VAAGWPPCLR MVAAIAVLTK
1080 DAGKLTMGQP LVILAPHAVE ALVKQPPDRW LSNARMTHYQ ALLLDTDRVQ FGPVVALNPA
1140 TLLPLPEEGL QHNCLDILAE AHGTRPDLTD QPLPDADHTW YTDGSSLLQE GQRKAGAAVT
1200 TETEVIWAKA LPAGTSAQRA ELIALTQALK MAEGKKLNVY TDSRYAFATA HIHGEIYRRR
1260 GLLTSEGKEI KNKDEILALL KALFLPKRLS IIHCPGHQKG HSAEARGNRM ADQAARKAAI
1320 TETPDTSTLL IENSSPYTSE HFHYTVTDIK DLTKLGAIYD KTKKYWVYQG KPVMPDQFTF
1380 ELLDFLHQLT HLSFSKMKAL LERSHSPYYM LNRDRTLKNI TETCKACAQV NASKSAVKQG
1440 TRVRGHRPGT HWEIDFTEIK PGLYGYKYLL VFIDTFSGWI EAFPTKKETA KVVTKKLLEE
1500 IFPRFGMPQV LGTDNGPAFV SKVSQTVADL LGIDWKLHCA YRPQSSGQVE RMNRTIKETL
1560 TKLTLATGSR DWVLLLPLAL YRARNTPGPH GLTPYEILYG APPPLVNFPD PDMTRVTNSP
1620 SLQAHLQALY LVQHEVWRPL AAAYQEQLDR PVVPHPYRVG DTVWVRRHQT KNLEPRWKGP
1680 YTVLLTTPTA LKVDGIAAWI HAAHVKAADP GGGPSSRLTW RVQRSQNPLK IRLTREAP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
207602
Shinnick T.M.,Lerner R.A.,Sutcliffe J.G.
Nucleotide sequence of Moloney murine leukaemia virus.
Nature
293
543-548
1981
207604
Henderson L.E.,Krutzsch H.C.,Oroszlan S.
Myristyl amino-terminal acylation of murine retrovirus proteins: an unusual post-translational proteins modification.
Proc. Natl. Acad. Sci. U.S.A.
80
339-343
1983
207605
Henderson L.E.,Copeland T.D.,Sowder R.C.,Smythers G.W.,Oroszlan S.
Primary structure of the low molecular weight nucleic acid-binding proteins of murine leukemia viruses.
J. Biol. Chem.
256
8400-8406
1981
207606
Yoshinaka Y.,Katoh I.,Copeland T.D.,Oroszlan S.
Murine leukemia virus protease is encoded by the gag-pol gene and is synthesized through suppression of an amber termination codon.
Proc. Natl. Acad. Sci. U.S.A.
82
1618-1622
1985
207607
Yang F.,Roth M.J.
Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase.
J. Virol.
75
9561-9570
2001
207608
Mayo K.,McDermott J.,Barklis E.
Hexagonal organization of Moloney murine leukemia virus capsid proteins.
Virology
298
30-38
2002
207609
Yueh A.,Goff S.P.
Phosphorylated serine residues and an arginine-rich domain of the moloney murine leukemia virus p12 protein are required for early events of viral infection.
J. Virol.
77
1820-1829
2003
207610
Alvarez E.,Menendez-Arias L.,Carrasco L.
The eukaryotic translation initiation factor 4GI is cleaved by different retroviral proteases.
J. Virol.
77
12392-12400
2003
207611
Orlova M.,Yueh A.,Leung J.,Goff S.P.
Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination.
Cell
115
319-331
2003
207612
Villanueva R.A.,Jonsson C.B.,Jones J.,Georgiadis M.M.,Roth M.J.
Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions.
Virology
316
146-160
2003
207613
Segura-Morales C.,Pescia C.,Chatellard-Causse C.,Sadoul R.,Bertrand E.,Basyuk E.
Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.
J. Biol. Chem.
280
27004-27012
2005
207614
Yueh A.,Leung J.,Bhattacharyya S.,Perrone L.A.,de los Santos K.,Pu S.-Y.,Goff S.P.
Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection.
J. Virol.
80
342-352
2006
207615
Feher A.,Boross P.,Sperka T.,Miklossy G.,Kadas J.,Bagossi P.,Oroszlan S.,Weber I.T.,Tozser J.
Characterization of the murine leukemia virus protease and its comparison with the human immunodeficiency virus type 1 protease.
J. Gen. Virol.
87
1321-1330
2006
207616
Prizan-Ravid A.,Elis E.,Laham-Karam N.,Selig S.,Ehrlich M.,Bacharach E.
The Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex.
PLoS Pathog.
6
0-0
2010
207617
Elis E.,Ehrlich M.,Prizan-Ravid A.,Laham-Karam N.,Bacharach E.
p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes.
PLoS Pathog.
8
0-0
2012
207618
Georgiadis M.M.,Jessen S.M.,Ogata C.M.,Telesnitsky A.,Goff S.P.,Hendrickson W.A.
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase.
Structure
3
879-892
1995
207619
Najmudin S.,Cote M.L.,Sun D.,Yohannan S.,Montano S.P.,Gu J.,Georgiadis M.M.
Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain.
J. Mol. Biol.
296
613-632
2000
207620
Cote M.L.,Georgiadis M.M.
Structure of a pseudo-16-mer DNA with stacked guanines and two G-A mispairs complexed with the N-terminal fragment of Moloney murine leukemia virus reverse transcriptase.
Acta Crystallogr. D
57
1238-1250
2001
207621
Crowther R.L.,Remeta D.P.,Minetti C.A.,Das D.,Montano S.P.,Georgiadis M.M.
Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase.
Proteins
57
15-26
2004
207622
Das D.,Georgiadis M.M.
The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus.
Structure
12
819-829
2004
207623
Lim D.,Gregorio G.G.,Bingman C.,Martinez-Hackert E.,Hendrickson W.A.,Goff S.P.
Crystal structure of the moloney murine leukemia virus RNase H domain.
J. Virol.
80
8379-8389
2006
207624
Montano S.P.,Cote M.L.,Roth M.J.,Georgiadis M.M.
Crystal structures of oligonucleotides including the integrase processing site of the Moloney murine leukemia virus.
Nucleic Acids Res.
34
5353-5360
2006
207625
Miller S.B.,Yildiz F.Z.,Lo J.A.,Wang B.,D'Souza V.M.
A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing.
Nature
515
591-595
2014
207626
Tang X.,Zhu Y.,Baker S.L.,Bowler M.W.,Chen B.J.,Chen C.,Hogg J.R.,Goff S.P.,Song H.
Structural basis of suppression of host translation termination by Moloney murine leukemia Virus.
Nat. Commun.
7
12070-12070
2016
207627
Guan R.,Aiyer S.,Cote M.L.,Xiao R.,Jiang M.,Acton T.B.,Roth M.J.,Montelione G.T.
X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition.
Proteins
85
647-656
2017
