Sequence of CP46A_MOUSE
EC Number:1.14.14.25
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.25
General information:
Sequence
0 MSPGLLLLGS AVLLAFGLCC TFVHRARSRY EHIPGPPRPS FLLGHLPYFW KKDEDCGRVL
60 QDVFLDWAKK YGPVVRVNVF YKTSVIVTSP ESVKKFLMST KYNKDSKMYR ALQTVFGERL
120 FGQGLVSECD YGRWYKQRKV MDLAFSRSSL VSLMETFNEK AEQLVEILEA KADGQTPVSM
180 QDMLTCATID ILAKAAFGME TSMLLGAQKP LSQAVKVMLE GISASRNTLA KFMPGKRKQL
240 REIRESIRLL RQVGKDWVQR RREALKRGED MPADILTQIL KAEEGAQDDE VLLDNFVTFF
300 IAGHETSANH LAFTVMELSR QPEIVARLQA EVDEVVGSKR HLDYEDLGRL QYLSQVLKES
360 LRLYPPAWGT FRLLEEETLI DGVRVPGNTP LLFSTYVMGR MDTYFEDPLT FNPDRFGPGA
420 PKPRFTYFPF SLGHRSCIGQ QFAQMEVKVV MAKLLQRIEF RLVPGQRFGL QEQATLKPLD
480 PVLCTLRPRG WQPAPPPPPC
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
20374
Lund E.G.,Guileyardo J.M.,Russell D.W.
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
Proc. Natl. Acad. Sci. U.S.A.
96
7238-7243
1999
20375
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
20376
Kotti T.J.,Ramirez D.M.,Pfeiffer B.E.,Huber K.M.,Russell D.W.
Brain cholesterol turnover required for geranylgeraniol production and learning in mice.
Proc. Natl. Acad. Sci. U.S.A.
103
3869-3874
2006
20377
Ramirez D.M.,Andersson S.,Russell D.W.
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain.
J. Comp. Neurol.
507
1676-1693
2008
20378
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
20379
Mast N.,Anderson K.W.,Lin J.B.,Li Y.,Turko I.V.,Tatsuoka C.,Bjorkhem I.,Pikuleva I.A.
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
J. Biol. Chem.
292
4913-4924
2017
