Sequence of NNMT_MOUSE
EC Number:2.1.1.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-adenosyl-L-methionine + nicotinamide + H+ = S-adenosyl-L-homocysteine + 1-methylnicotinamide
Other sequences found for EC No. 2.1.1.1
General information:
Sequence
0 MESGFTSKDT YLSHFNPRDY LEKYYSFGSR HCAENEILRH LLKNLFKIFC LGAVKGELLI
60 DIGSGPTIYQ LLSACESFTE IIVSDYTDQN LWELQKWLKK EPGAFDWSPV VTYVCDLEGN
120 RMKGPEKEEK LRRAIKQVLK CDVTQSQPLG GVSLPPADCL LSTLCLDAAC PDLPAYRTAL
180 RNLGSLLKPG GFLVMVDALK SSYYMIGEQK FSSLPLGWET VRDAVEEAGY TIEQFEVISQ
240 NYSSTTSNNE GLFSLVGRKP GRSE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
195719
Yan L.,Otterness D.M.,Craddock T.L.,Weinshilboum R.M.
Mouse liver nicotinamide N-methyltransferase: cDNA cloning, expression, and nucleotide sequence polymorphisms.
Biochem. Pharmacol.
54
1139-1149
1997
195720
Yan L.,Otterness D.M.,Kozak C.A.,Weinshilboum R.M.
Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization.
DNA Cell Biol.
17
659-667
1998
195721
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
195722
Kraus D.,Yang Q.,Kong D.,Banks A.S.,Zhang L.,Rodgers J.T.,Pirinen E.,Pulinilkunnil T.C.,Gong F.,Wang Y.C.,Cen Y.,Sauve A.A.,Asara J.M.,Peroni O.D.,Monia B.P.,Bhanot S.,Alhonen L.,Puigserver P.,Kahn B.B.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Nature
508
258-262
2014
195723
Hong S.,Moreno-Navarrete J.M.,Wei X.,Kikukawa Y.,Tzameli I.,Prasad D.,Lee Y.,Asara J.M.,Fernandez-Real J.M.,Maratos-Flier E.,Pissios P.
Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.
Nat. Med.
21
887-894
2015
195725
Kannt A.,Rajagopal S.,Kadnur S.V.,Suresh J.,Bhamidipati R.K.,Swaminathan S.,Hallur M.S.,Kristam R.,Elvert R.,Czech J.,Pfenninger A.,Rudolph C.,Schreuder H.,Chandrasekar D.V.,Mane V.S.,Birudukota S.,Shaik S.,Zope B.R.,Burri R.R.,Anand N.N.,Thakur M.K.,Singh M.,Parveen R.,Kandan S.,Mullangi R.,Yura T.,Gosu R.,Ruf S.,Dhakshinamoorthy S.
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Sci. Rep.
8
3660-3660
2018
