Sequence of CPT2_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
carnitine O-palmitoyltransferase
P23786
Homo sapiens
658
73777
Reaction
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MVPRLLLRAW PRGPAVGPGA PSRPLSAGSG PGQYLQRSIV PTMHYQDSLP RLPIPKLEDT
 60 IRRYLSAQKP LLNDGQFRKT EQFCKSFENG IGKELHEQLV ALDKQNKHTS YISGPWFDMY
120 LSARDSVVLN FNPFMAFNPD PKSEYNDQLT RATNMTVSAI RFLKTLRAGL LEPEVFHLNP
180 AKSDTITFKR LIRFVPSSLS WYGAYLVNAY PLDMSQYFRL FNSTRLPKPS RDELFTDDKA
240 RHLLVLRKGN FYIFDVLDQD GNIVSPSEIQ AHLKYILSDS SPAPEFPLAY LTSENRDIWA
300 ELRQKLMSSG NEESLRKVDS AVFCLCLDDF PIKDLVHLSH NMLHGDGTNR WFDKSFNLII
360 AKDGSTAVHF EHSWGDGVAV LRFFNEVFKD STQTPAVTPQ SQPATTDSTV TVQKLNFELT
420 DALKTGITAA KEKFDATMKT LTIDCVQFQR GGKEFLKKQK LSPDAVAQLA FQMAFLRQYG
480 QTVATYESCS TAAFKHGRTE TIRPASVYTK RCSEAFVREP SRHSAGELQQ MMVECSKYHG
540 QLTKEAAMGQ GFDRHLFALR HLAAAKGIIL PELYLDPAYG QINHNVLSTS TLSSPAVNLG
600 GFAPVVSDGF GVGYAVHDNW IGCNVSSYPG RNAREFLQCV EKALEDMFDA LEGKSIKS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
18945
Finocchiaro G.,Taroni F.,Rocchi M.,Martin A.L.,Colombo I.,Tarelli G.T.,Didonato S.
cDNA cloning, sequence analysis, and chromosomal localization of the gene for human carnitine palmitoyltransferase.
Proc. Natl. Acad. Sci. U.S.A.
88
661-665
1991
18946
Finocchiaro G.,Taroni F.,Rocchi M.,Martin A.L.,Colombo I.,Tarelli G.T.,Didonato S.
Proc. Natl. Acad. Sci. U.S.A.
88
10981-10981
1991
18947
Verderio E.,Cavadini P.,Montermini L.,Wang H.,Lamantea E.,Finocchiaro G.,Didonato S.,Gellera C.,Taroni F.
Carnitine palmitoyltransferase II deficiency: structure of the gene and characterization of two novel disease-causing mutations.
Hum. Mol. Genet.
4
19-29
1995
18948
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
18949
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
18951
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
18952
Finocchiaro G.,Colombo I.,Didonato S.
Purification, characterization and partial amino acid sequences of carnitine palmitoyl-transferase from human liver.
FEBS Lett.
274
163-166
1990
18953
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
18954
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
18955
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
18956
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
18958
Taroni F.,Verderio E.,Fiorucci S.,Cavadini P.,Finocchiaro G.,Uziel G.,Lamantea E.,Gellera C.,Didonato S.
Molecular characterization of inherited carnitine palmitoyltransferase II deficiency.
Proc. Natl. Acad. Sci. U.S.A.
89
8429-8433
1992
18959
Taroni F.,Verderio E.,Dworzak F.,Willems P.J.,Cavadini P.,Didonato S.
Identification of a common mutation in the carnitine palmitoyltransferase II gene in familial recurrent myoglobinuria patients.
Nat. Genet.
4
314-320
1993
18960
Bonnefont J.-P.,Taroni F.,Cavadini P.,Cepanec C.,Brivet M.,Saudubray J.-M.,Leroux J.-P.,Demaugre F.
Molecular analysis of carnitine palmitoyltransferase II deficiency with hepatocardiomuscular expression.
Am. J. Hum. Genet.
58
971-978
1996
18962
Wataya K.,Akanuma J.,Cavadini P.,Aoki Y.,Kure S.,Invernizzi F.,Yoshida I.,Kira J.,Taroni F.,Matsubara Y.,Narisawa K.
Two CPT2 mutations in three Japanese patients with carnitine palmitoyltransferase II deficiency: functional analysis and association with polymorphic haplotypes and two clinical phenotypes.
Hum. Mutat.
11
377-386
1998
18963
Yang B.-Z.,Ding J.-H.,Dewese T.,Roe D.,He G.,Wilkinson J.,Day D.W.,Demaugre F.,Rabier D.,Brivet M.,Roe C.
Identification of four novel mutations in patients with carnitine palmitoyltransferase II (CPT II) deficiency.
Mol. Genet. Metab.
64
229-236
1998
18964
Taggart R.T.,Smail D.,Apolito C.,Vladutiu G.D.
Novel mutations associated with carnitine palmitoyltransferase II deficiency.
Hum. Mutat.
13
210-220
1999
18965
Elpeleg O.N.,Hammerman C.,Saada A.,Shaag A.,Golzand E.,Hochner-Celnikier D.,Berger I.,Nadjari M.
Antenatal presentation of carnitine palmitoyltransferase II deficiency.
Am. J. Med. Genet.
102
183-187
2001
18966
Olpin S.E.,Afifi A.,Clark S.,Manning N.J.,Bonham J.R.,Dalton A.,Leonard J.V.,Land J.M.,Andresen B.S.,Morris A.A.,Muntoni F.,Turnbull D.,Pourfarzam M.,Rahman S.,Pollitt R.J.
Mutation and biochemical analysis in carnitine palmitoyltransferase type II (CPT II) deficiency.
J. Inherit. Metab. Dis.
26
543-557
2003
18967
Sigauke E.,Rakheja D.,Kitson K.,Bennett M.J.
Carnitine palmitoyltransferase II deficiency: a clinical, biochemical, and molecular review.
Lab. Invest.
83
1543-1554
2003
18968
Oerngreen M.C.,Dunoe M.,Ejstrup R.,Christensen E.,Schwartz M.,Sacchetti M.,Vissing J.
Fuel utilization in subjects with carnitine palmitoyltransferase 2 gene mutations.
Ann. Neurol.
57
60-66
2005
18969
Chen Y.,Mizuguchi H.,Yao D.,Ide M.,Kuroda Y.,Shigematsu Y.,Yamaguchi S.,Yamaguchi M.,Kinoshita M.,Kido H.
Thermolabile phenotype of carnitine palmitoyltransferase II variations as a predisposing factor for influenza-associated encephalopathy.
FEBS Lett.
579
2040-2044
2005
18970
Bunger M.K.,Cargile B.J.,Sevinsky J.R.,Deyanova E.,Yates N.A.,Hendrickson R.C.,Stephenson J.L. Jr.
Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.
J. Proteome Res.
6
2331-2340
2007
18971
Yao D.,Mizuguchi H.,Yamaguchi M.,Yamada H.,Chida J.,Shikata K.,Kido H.
Thermal instability of compound variants of carnitine palmitoyltransferase II and impaired mitochondrial fuel utilization in influenza-associated encephalopathy.
Hum. Mutat.
29
718-727
2008
18972
Mak C.M.,Lam C.W.,Fong N.C.,Siu W.K.,Lee H.C.,Siu T.S.,Lai C.K.,Law C.Y.,Tong S.F.,Poon W.T.,Lam D.S.,Ng H.L.,Yuen Y.P.,Tam S.,Que T.L.,Kwong N.S.,Chan A.Y.
Fatal viral infection-associated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants.
J. Hum. Genet.
56
617-621
2011