Sequence of HUTZ_VIBCH

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
heme oxygenase (biliverdin-IX-beta and delta-forming)
Q9KL41
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
176
20300
Reaction
protoheme + 3 reduced acceptor + 3 O2 = biliverdin-IX-beta + CO + Fe2+ + 3 acceptor + 3 H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MDQQVKQERL QGRLEPEIKE FRQERKTLQL ATVDAQGRPN VSYAPFVQNQ EGYFVLISHI
 60 ARHARNLEVN PQVSIMMIED ETEAKQLFAR KRLTFDAVAS MVERDSELWC QVIAQMGERF
120 GEIIDGLSQL QDFMLFRLQP EQGLFVKGFG QAYQVSGDDL VDFVHLEEGH RKISNG
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
165796
Heidelberg J.F.,Eisen J.A.,Nelson W.C.,Clayton R.A.,Gwinn M.L.,Dodson R.J.,Haft D.H.,Hickey E.K.,Peterson J.D.,Umayam L.A.,Gill S.R.,Nelson K.E.,Read T.D.,Tettelin H.,Richardson D.L.,Ermolaeva M.D.,Vamathevan J.J.,Bass S.,Qin H.,Dragoi I.,Sellers P.,McDonald L.A.,Utterback T.R.,Fleischmann R.D.,Nierman W.C.,White O.,Salzberg S.L.,Smith H.O.,Colwell R.R.,Mekalanos J.J.,Venter J.C.,Fraser C.M.
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.
Nature
406
477-483
2000
165797
Wyckoff E.E.,Schmitt M.,Wilks A.,Payne S.M.
HutZ is required for efficient heme utilization in Vibrio cholerae.
J. Bacteriol.
186
4142-4151
2004
165798
Uchida T.,Sekine Y.,Matsui T.,Ikeda-Saito M.,Ishimori K.
A heme degradation enzyme, HutZ, from Vibrio cholerae.
Chem. Commun. (Camb.)
48
6741-6743
2012
165799
Sekine Y.,Tanzawa T.,Tanaka Y.,Ishimori K.,Uchida T.
Cytoplasmic heme-binding protein (HutX) from Vibrio cholerae is an intracellular heme transport protein for the heme-degrading enzyme, HutZ.
Biochemistry
55
884-893
2016
165800
Uchida T.,Dojun N.,Sekine Y.,Ishimori K.
Heme proximal hydrogen bonding between His170 and Asp132 plays an essential role in the heme degradation reaction of HutZ from Vibrio cholerae.
Biochemistry
56
2723-2734
2017
165801
Dojun N.,Sekine Y.,Ishimori K.,Uchida T.
Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae.
Dalton Trans.
46
5147-5150
2017
165802
Uchida T.,Sekine Y.,Dojun N.,Lewis-Ballester A.,Ishigami I.,Matsui T.,Yeh S.R.,Ishimori K.
Reaction intermediates in the heme degradation reaction by HutZ from Vibrio cholerae.
Dalton Trans.
46
8104-8109
2017
165803
Liu X.,Gong J.,Wei T.,Wang Z.,Du Q.,Zhu D.,Huang Y.,Xu S.,Gu L.
Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation.
BMC Struct. Biol.
12
23-23
2012