Sequence of VM2T3_PROMU
EC Number:3.4.24.44
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Cleavage of Asn3-/-Gln, Ser9-/-His and Ala14-/-Leu bonds in insulin B chain and Tyr14-/-Gln and Thr8-/-Ser in A chain. Cleaves type IV collagen at Ala73-/-Gln in alpha1(IV) and at Gly7-/-Leu in alpha2(IV)
Other sequences found for EC No. 3.4.24.44
General information:
Sequence
0 MIEVLLVTIC LAVFPYQGSS IILESGNVND YEVVYPRKVS ALPKGAVQPK YEDAMQYEFK
60 VNGEAVVLHL EKNKGLFSED YSETHYSPDG REITTYPSVE DHCYYHGRIH NDADSTASIS
120 ACDGLKGYFK LQGETYPIEP LELSDSEAHA VFKYENVEKE DEAPKMCGVT QNWESDESIK
180 KASQLYLTPE QQRFPQRYIK LAIVVDHGMY TKYSSNFKKI RKRVHQMVSN INEMCRPLNI
240 AITLALLDVW SEKDFITVQA DAPTTAGLFG DWRERVLLKK KNHDHAQLLT DTNFARNTIG
300 WAYVGRMCDE KYSVAVVKDH SSKVFMVAVT MTHELGHNLG MEHDDKDKCK CDTCIMSAVI
360 SDKQSKLFSD CSKDYYQTFL TNDNPQCILN APLRTDTVST PVSGNEFLEA GEECDCGSPE
420 NPCCDAATCK LRPGAQCAEG LCCDQCRFKK KRTICRRARG DNPDDRCTGQ SADCPRNGLY
480 G
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1142189
Huang K.F.,Hung C.C.,Pan F.M.,Chow L.P.,Tsugita A.,Chiou S.H.
Characterization of multiple metalloproteinases with fibrinogenolytic activity from the venom of Taiwan habu (Trimeresurus mucrosquamatus): protein microsequencing coupled with cDNA sequence analysis.
Biochem. Biophys. Res. Commun.
216
223-233
1995
1142191
Tsai I.H.,Wang Y.M.,Lee Y.H.
Characterization of a cDNA encoding the precursor of platelet aggregation inhibition and metalloproteinase from Trimeresurus mucrosquamatus venom.
Biochim. Biophys. Acta
1200
337-340
1994
1142193
Huang K.-F.,Hung C.C.,Chiou S.-H.
Characterization of three fibrinogenolytic proteases isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus).
Biochem. Mol. Biol. Int.
31
1041-1050
1993
1142194
Huang K.F.,Hung C.C.,Wu S.H.,Chiou S.H.
Characterization of three endogenous peptide inhibitors for multiple metalloproteinases with fibrinogenolytic activity from the venom of Taiwan habu (Trimeresurus mucrosquamatus).
Biochem. Biophys. Res. Commun.
248
562-568
1998
1142195
Huang K.-F.,Chiou S.-H.,Ko T.-P.,Yuann J.M.,Wang A.H.-J.
The 1.35 A structure of cadmium-substituted TM-3, a snake-venom metalloproteinase from Taiwan habu: elucidation of a TNFalpha-converting enzyme-like active-site structure with a distorted octahedral geometry of cadmium.
Acta Crystallogr. D
58
1118-1128
2002
1142196
Huang K.-F.,Chiou S.-H.,Ko T.-P.,Wang A.H.-J.
Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues.
Eur. J. Biochem.
269
3047-3056
2002
