Sequence of CBPC6_MOUSE
EC Number:3.4.17.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
Other sequences found for EC No. 3.4.17.24
General information:
Sequence
0 MAERSQTAPE AGNDTGNEDA IGGNVNKYIV LPNGYSGQPK KGHLTFDACF ESGNLGRVEQ
60 VSDFEYDLFI RPDTCNPRFR VWFNFTVENV KELQRVIFNI VNFSKTKSLY RDGMAPMVKS
120 TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF AFCFDREDDI YQFAYCYPYT YTRFQHYLDS
180 LQKKNMDYFF REQLGQSVQQ RQLDLLTITS PENLREGSEK KVIFITGRVH PGETPSSFVC
240 QGIIDFLVSQ HPIARVLREH LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWAH
300 PTLHGVKQLI IKMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ RQSIFPKLLC
360 QNAEDFSYTS TSFNRDAVKA GTGRRFLGGL LDHSSYCYTL EVSFYSYIIG GTTAAVPYTE
420 EAYMKLGRNV ARTFLDYYRL NSLVEKIAVP MPRLRSKEER RLGWEHPSCL RAEQPLEVLG
480 IPMCSGKALN EHLGNDIQWH LDCGSSTLPL GLISCSPSSS ASWNDMAMSN SILLPDHSFH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
14094
Kalinina E.,Biswas R.,Berezniuk I.,Hermoso A.,Aviles F.X.,Fricker L.D.
A novel subfamily of mouse cytosolic carboxypeptidases.
FASEB J.
21
836-850
2007
14095
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
14096
Rogowski K.,van Dijk J.,Magiera M.M.,Bosc C.,Deloulme J.C.,Bosson A.,Peris L.,Gold N.D.,Lacroix B.,Grau M.B.,Bec N.,Larroque C.,Desagher S.,Holzer M.,Andrieux A.,Moutin M.J.,Janke C.
A family of protein-deglutamylating enzymes associated with neurodegeneration.
Cell
143
564-578
2010
14097
Tort O.,Tanco S.,Rocha C.,Bieche I.,Seixas C.,Bosc C.,Andrieux A.,Moutin M.J.,Aviles F.X.,Lorenzo J.,Janke C.
The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.
Mol. Biol. Cell
25
3017-3027
2014
14098
Xia P.,Ye B.,Wang S.,Zhu X.,Du Y.,Xiong Z.,Tian Y.,Fan Z.
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.
Nat. Immunol.
17
369-378
2016
14099
Ye B.,Liu B.,Hao L.,Zhu X.,Yang L.,Wang S.,Xia P.,Du Y.,Meng S.,Huang G.,Qin X.,Wang Y.,Yan X.,Li C.,Hao J.,Zhu P.,He L.,Tian Y.,Fan Z.
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
Nat. Commun.
9
1261-1261
2018
