Sequence of CSLB_PEDHD
EC Number:4.2.2.19
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
chondroitin B lyase
Q46079
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3)
506
56337
Reaction
[dermatan sulfate]n = [dermatan sulfate]n-1 + 4-deoxy-beta-D-gluc-4-enuronosyl-1,3-GalNAc
Other sequences found for EC No. 4.2.2.19
General information:
Sequence
0 MKMLNKLAGY LLPIMVLLNV APCLGQVVAS NETLYQVVKE VKPGGLVQIA DGTYKDVQLI
60 VSNSGKSGLP ITIKALNPGK VFFTGDAKVE LRGEHLILEG IWFKDGNRAI QAWKSHGPGL
120 VAIYGSYNRI TACVFDCFDE ANSAYITTSL TEDGKVPQHC RIDHCSFTDK ITFDQVINLN
180 NTARAIKDGS VGGPAMYHRV DHCFFSNPQK PGNAGGGIRI GYYRNDIGRC LVDSNLFMRQ
240 DSEAEIITSK SQENVYYGNT YLNCQGTMNF RHGDHQVAIN NFYIGNDQRF GYGGMFVWGS
300 RHVIACNYFE LSETIKSRGN AALYLNPGAM ASEHALAFDM LIANNAFINV NGYAIHFNPL
360 DERRKEYCAA NRLKFETPHQ LMLKGNLFFK DKPYVYPFFK DDYFIAGKNS WTGNVALGVE
420 KGIPVNISAN RSAYKPVKIK DIQPIEGIAL DLNALISKGI TGKPLSWDEV RPYWLKEMPG
480 TYALTARLSA DRAAKFKAVI KRNKEH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
148626
Tkalec A.L.,Fink D.,Blain F.,Zhang-Sun G.,Laliberte M.,Bennett D.C.,Gu K.,Zimmermann J.J.F.,Su H.
Isolation and expression in Escherichia coli of cslA and cslB, genes coding for the chondroitin sulfate-degrading enzymes chondroitinase AC and chondroitinase B, respectively, from Flavobacterium heparinum.
Appl. Environ. Microbiol.
66
29-35
2000
148627
Han C.,Spring S.,Lapidus A.,Del Rio T.G.,Tice H.,Copeland A.,Cheng J.F.,Lucas S.,Chen F.,Nolan M.,Bruce D.,Goodwin L.,Pitluck S.,Ivanova N.,Mavromatis K.,Mikhailova N.,Pati A.,Chen A.,Palaniappan K.,Land M.,Hauser L.,Chang Y.J.,Jeffries C.C.,Saunders E.,Chertkov O.,Brettin T.,Goker M.,Rohde M.,Bristow J.,Eisen J.A.,Markowitz V.,Hugenholtz P.,Kyrpides N.C.,Klenk H.P.,Detter J.C.
Complete genome sequence of Pedobacter heparinus type strain (HIM 762-3).
Stand. Genomic Sci.
1
54-62
2009
148628
Pojasek K.,Raman R.,Kiley P.,Venkataraman G.,Sasisekharan R.
Biochemical characterization of the chondroitinase B active site.
J. Biol. Chem.
277
31179-31186
2002
148629
Huang W.,Matte A.,Li Y.,Kim Y.S.,Linhardt R.J.,Su H.,Cygler M.
Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution.
J. Mol. Biol.
294
1257-1269
1999
148630
Huang W.,Boju L.,Tkalec A.L.,Su H.,Yang H.O.,Gunay N.S.,Linhardt R.J.,Kim Y.S.,Matte A.,Cygler M.
Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
Biochemistry
40
2359-2372
2001
