Sequence of BLMH_RAT
EC Number:3.4.22.40
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred
Other sequences found for EC No. 3.4.22.40
General information:
Sequence
0 MNNAGLNSEK VAALIQKLNS DPQFVLAQNV GTTHDLLDIC LKRATVQGAQ HVFQHVVPQE
60 GKPVTNQKSS GRCWIFSCLN VMRLPFMKKF NIEEFEFSQS YLFFWDKVER CYFFLNAFVD
120 TAQKKEPEDG RLVQYLLMNP TNDGGQWDML VNIVEKYGVV PKKCFPESHT TEATRRMNDI
180 LNHKMREFCI RLRNLVHSGA TKGEISSTQD AMMEEIFRVV CICLGNPPET FTWEYRDKDK
240 NYHKVGPITP LQFYKEHVKP LFNMEDKICF VNDPRPQHKY NKLYTVDYLS NMVGGRKTLY
300 NNQPIDFLKK MVAASIRDGE AVWFGCDVGK HFNGKLGLSD MNVYDHELVF GVSLKNMNKA
360 ERLAFGESLM THAMTFTAVS EKDDQEGAFV KWRVENSWGE DHGHKGYLCM TDEWFSEYVY
420 EVVVDKKHVP EEVLAVLEQE PIVLPAWDPM GALA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
11143
Takeda A.,Masuda Y.,Yamamoto T.,Hirabayashi T.,Nakamura Y.,Nakaya K.
Cloning and analysis of cDNA encoding rat bleomycin hydrolase, a DNA-binding cysteine protease.
J. Biochem.
120
353-359
1996
11144
Takeda A.,Higuchi D.,Yamamoto T.,Nakamura Y.,Masuda Y.,Hirabayashi T.,Nakaya K.
Purification and characterization of bleomycin hydrolase, which represents a new family of cysteine proteases, from rat skin.
J. Biochem.
119
29-36
1996
