Sequence of BLK_MOUSE
EC Number:2.7.10.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2
General information:
Sequence
0 MGLLSSKRQV SEKGKGWSPV KIRTQDKAPP PLPPLVVFNH LAPPSPNQDP DEEERFVVAL
60 FDYAAVNDRD LQVLKGEKLQ VLRSTGDWWL ARSLVTGREG YVPSNFVAPV ETLEVEKWFF
120 RTISRKDAER QLLAPMNKAG SFLIRESESN KGAFSLSVKD ITTQGEVVKH YKIRSLDNGG
180 YYISPRITFP TLQALVQHYS KKGDGLCQKL TLPCVNLAPK NLWAQDEWEI PRQSLKLVRK
240 LGSGQFGEVW MGYYKNNMKV AIKTLKEGTM SPEAFLGEAN VMKTLQHERL VRLYAVVTRE
300 PIYIVTEYMA RGCLLDFLKT DEGSRLSLPR LIDMSAQVAE GMAYIERMNS IHRDLRAANI
360 LVSETLCCKI ADFGLARIID SEYTAQEGAK FPIKWTAPEA IHFGVFTIKA DVWSFGVLLM
420 EIVTYGRVPY PGMSNPEVIR SLEHGYRMPC PETCPPELYN DIITECWRGR PEERPTFEFL
480 QSVLEDFYTA TEGQYELQP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
11076
Dymecki S.M.,Niederhuber J.E.,Desiderio S.V.
Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.
Science
247
332-336
1990
11077
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
11079
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
11080
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
11081
Burkhardt A.L.,Brunswick M.,Bolen J.B.,Mond J.J.
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.
Proc. Natl. Acad. Sci. U.S.A.
88
7410-7414
1991
11082
Dymecki S.M.,Zwollo P.,Zeller K.,Kuhajda F.P.,Desiderio S.V.
Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk.
J. Biol. Chem.
267
4815-4823
1992
11083
Lin J.,Justement L.B.
The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases.
J. Immunol.
149
1548-1555
1992
11084
Yao X.R.,Scott D.W.
Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A.
90
7946-7950
1993
11085
Zwollo P.,Desiderio S.
Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein.
J. Biol. Chem.
269
15310-15317
1994
11086
Saouaf S.J.,Mahajan S.,Rowley R.B.,Kut S.A.,Fargnoli J.,Burkhardt A.L.,Tsukada S.,Witte O.N.,Bolen J.B.
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.
Proc. Natl. Acad. Sci. U.S.A.
91
9524-9528
1994
11087
Wasserman R.,Li Y.S.,Hardy R.R.
Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement.
J. Immunol.
155
644-651
1995
11088
Saouaf S.J.,Kut S.A.,Fargnoli J.,Rowley R.B.,Bolen J.B.,Mahajan S.
Reconstitution of the B cell antigen receptor signaling components in COS cells.
J. Biol. Chem.
270
27072-27078
1995
11089
Mahajan S.,Fargnoli J.,Burkhardt A.L.,Kut S.A.,Saouaf S.J.,Bolen J.B.
Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase.
Mol. Cell. Biol.
15
5304-5311
1995
11090
Saouaf S.J.,Wolven A.,Resh M.D.,Bolen J.B.
Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate.
Biochem. Biophys. Res. Commun.
234
325-329
1997
11091
Zwollo P.,Rao S.,Wallin J.J.,Gackstetter E.R.,Koshland M.E.
The transcription factor NF-kappaB/p50 interacts with the blk gene during B cell activation.
J. Biol. Chem.
273
18647-18655
1998
11092
Malek S.N.,Dordai D.I.,Reim J.,Dintzis H.,Desiderio S.
Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.
Proc. Natl. Acad. Sci. U.S.A.
95
7351-7356
1998
11093
Oda H.,Kumar S.,Howley P.M.
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.
Proc. Natl. Acad. Sci. U.S.A.
96
9557-9562
1999
11094
Tretter T.,Ross A.E.,Dordai D.I.,Desiderio S.
Mimicry of pre-B-cell receptor signaling by activation of the tyrosine kinase Blk.
J. Exp. Med.
198
1863-1873
2003
11095
Saijo K.,Schmedt C.,Su I.H.,Karasuyama H.,Lowell C.A.,Reth M.,Adachi T.,Patke A.,Santana A.,Tarakhovsky A.
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.
Nat. Immunol.
4
274-279
2003
11096
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
11097
Malhotra N.,Narayan K.,Cho O.H.,Sylvia K.E.,Yin C.,Melichar H.,Rashighi M.,Lefebvre V.,Harris J.E.,Berg L.J.,Kang J.
A network of high-mobility group box transcription factors programs innate interleukin-17 production.
Immunity
38
681-693
2013
11098
Metzler W.J.,Leiting B.,Pryor K.,Mueller L.,Farmer B.T. II
The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry
35
6201-6211
1996
