Sequence of AMPN_ECOLI

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
membrane alanyl aminopeptidase
P04825
Escherichia coli (strain K12)
870
98919
Reaction
Release of an N-terminal amino acid, Xaa-/-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MTQQPQAKYR HDYRAPDYQI TDIDLTFDLD AQKTVVTAVS QAVRHGASDA PLRLNGEDLK
 60 LVSVHINDEP WTAWKEEEGA LVISNLPERF TLKIINEISP AANTALEGLY QSGDALCTQC
120 EAEGFRHITY YLDRPDVLAR FTTKIIADKI KYPFLLSNGN RVAQGELENG RHWVQWQDPF
180 PKPCYLFALV AGDFDVLRDT FTTRSGREVA LELYVDRGNL DRAPWAMTSL KNSMKWDEER
240 FGLEYDLDIY MIVAVDFFNM GAMENKGLNI FNSKYVLART DTATDKDYLD IERVIGHEYF
300 HNWTGNRVTC RDWFQLSLKE GLTVFRDQEF SSDLGSRAVN RINNVRTMRG LQFAEDASPM
360 AHPIRPDMVI EMNNFYTLTV YEKGAEVIRM IHTLLGEENF QKGMQLYFER HDGSAATCDD
420 FVQAMEDASN VDLSHFRRWY SQSGTPIVTV KDDYNPETEQ YTLTISQRTP ATPDQAEKQP
480 LHIPFAIELY DNEGKVIPLQ KGGHPVNSVL NVTQAEQTFV FDNVYFQPVP ALLCEFSAPV
540 KLEYKWSDQQ LTFLMRHARN DFSRWDAAQS LLATYIKLNV ARHQQGQPLS LPVHVADAFR
600 AVLLDEKIDP ALAAEILTLP SVNEMAELFD IIDPIAIAEV REALTRTLAT ELADELLAIY
660 NANYQSEYRV EHEDIAKRTL RNACLRFLAF GETHLADVLV SKQFHEANNM TDALAALSAA
720 VAAQLPCRDA LMQEYDDKWH QNGLVMDKWF ILQATSPAAN VLETVRGLLQ HRSFTMSNPN
780 RIRSLIGAFA GSNPAAFHAE DGSGYLFLVE MLTDLNSRNP QVASRLIEPL IRLKRYDAKR
840 QEKMRAALEQ LKGLENLSGD LYEKITKALA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
132035
Foglino M.,Gharbi S.,Lazdunski A.
Nucleotide sequence of the pepN gene encoding aminopeptidase N of Escherichia coli.
Gene
49
303-309
1986
132036
McCaman M.T.,Gabe J.D.
The nucleotide sequence of the pepN gene and its over-expression in Escherichia coli.
Gene
48
145-153
1986
132037
Oshima T.,Aiba H.,Baba T.,Fujita K.,Hayashi K.,Honjo A.,Ikemoto K.,Inada T.,Itoh T.,Kajihara M.,Kanai K.,Kashimoto K.,Kimura S.,Kitagawa M.,Makino K.,Masuda S.,Miki T.,Mizobuchi K.,Mori H.,Motomura K.,Nakamura Y.,Nashimoto H.,Nishio Y.,Saito N.,Sampei G.,Seki Y.,Tagami H.,Takemoto K.,Wada C.,Yamamoto Y.,Yano M.,Horiuchi T.
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.
DNA Res.
3
137-155
1996
132038
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
132039
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
132040
McCaman M.T.,Gabe J.D.
Sequence of the promoter and 5' coding region of pepN, and the amino-terminus of peptidase N from Escherichia coli K-12.
Mol. Gen. Genet.
204
148-152
1986
132041
Bally M.,Foglino M.,Bruschi M.,Murgier M.,Lazdunski A.
Nucleotide sequence of the promoter and amino-terminal encoding region of the Escherichia coli pepN gene.
Eur. J. Biochem.
155
565-569
1986
132042
Hayashi M.,Tabata K.,Yagasaki M.,Yonetani Y.
Effect of multidrug-efflux transporter genes on dipeptide resistance and overproduction in Escherichia coli.
FEMS Microbiol. Lett.
304
12-19
2010
132043
Ito K.,Nakajima Y.,Onohara Y.,Takeo M.,Nakashima K.,Matsubara F.,Ito T.,Yoshimoto T.
Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition.
J. Biol. Chem.
281
33664-33676
2006
132044
Addlagatta A.,Gay L.,Matthews B.W.
Structural basis for the unusual specificity of Escherichia coli aminopeptidase N.
Biochemistry
47
5303-5311
2008
132045
Fournie-Zaluski M.C.,Poras H.,Roques B.P.,Nakajima Y.,Ito K.,Yoshimoto T.
Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250.
Acta Crystallogr. D
65
814-822
2009