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Sequence of ABL2_HUMAN

EC Number:2.7.10.2

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.10.2
non-specific protein-tyrosine kinase
P42684
Homo sapiens
1182
128343
Swiss-Prot
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2

General information:

Sequence
show sequence in fasta format
   0 MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE
  60 DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA
 120 SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR
 180 SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST
 240 LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG
 300 EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV
 360 TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN
 420 HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT
 480 YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE
 540 TMFHDSSISE EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE
 600 NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR
 660 NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG FSFTPAQQEA NLVPPKCYGG
 720 SFAQRNLCND DGGGGGGSGT AGGGWSGITG FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR
 780 SNSTSSMSSG LPEQDRMAMT LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES
 840 AAPSRERPKA KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG
 900 MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG TDSQGNKFKL
 960 LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS DPTEEPTALT AGQSTSETQE
1020 GGKKAALGAV PISGKAGRPV MPPPQVPLPT SSISPAKMAN GTAGTKVALR KTKQAAEKIS
1080 ADKISKEALL ECADLLSSAL TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV
1140 SKLELSLQEL QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
127927
Kruh G.D.,Perego R.,Miki T.,Aaronson S.A.
The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
Proc. Natl. Acad. Sci. U.S.A.
87
5802-5806
1990
2198571
127928
Bianchi C.,Torsello B.,Angeloni V.,Bombelli S.,Soldi M.,Invernizzi L.,Brambilla P.,Perego R.A.
Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection.
J. Cell. Biochem.
105
1219-1227
2008
18810762
127929
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
14702039
127930
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
17974005
127932
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
16710414
127934
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
127935
Kruh G.D.,King C.R.,Kraus M.H.,Popescu N.C.,Amsbaugh S.C.,McBride W.O.,Aaronson S.A.
A novel human gene closely related to the abl proto-oncogene.
Science
234
1545-1548
1986
3787260
127936
Tanis K.Q.,Veach D.,Duewel H.S.,Bornmann W.G.,Koleske A.J.
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
Mol. Cell. Biol.
23
3884-3896
2003
12748290
127937
Hu H.,Bliss J.M.,Wang Y.,Colicelli J.
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
Curr. Biol.
15
815-823
2005
15886098
127938
Cao C.,Li Y.,Leng Y.,Li P.,Ma Q.,Kufe D.
Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.
Oncogene
24
2433-2440
2005
15735735
127939
Liu X.,Huang W.,Li C.,Li P.,Yuan J.,Li X.,Qiu X.B.,Ma Q.,Cao C.
Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
Mol. Cell
22
317-327
2006
16678104
127940
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nat. Biotechnol.
24
1285-1292
2006
16964243
127941
Boyle S.N.,Michaud G.A.,Schweitzer B.,Predki P.F.,Koleske A.J.
A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.
Curr. Biol.
17
445-451
2007
17306540
127942
Matsuoka S.,Ballif B.A.,Smogorzewska A.,McDonald E.R. III,Hurov K.E.,Luo J.,Bakalarski C.E.,Zhao Z.,Solimini N.,Lerenthal Y.,Shiloh Y.,Gygi S.P.,Elledge S.J.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science
316
1160-1166
2007
17525332
127943
Yogalingam G.,Pendergast A.M.
Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
J. Biol. Chem.
283
35941-35953
2008
18945674
127944
Woodring P.J.,Hunter T.,Wang J.Y.
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
J. Cell Sci.
116
2613-2626
2003
12775773
127945
Hernandez S.E.,Krishnaswami M.,Miller A.L.,Koleske A.J.
How do Abl family kinases regulate cell shape and movement?
Trends Cell Biol.
14
36-44
2004
14729179
127946
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
18691976
127947
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
18669648
127948
Backert S.,Feller S.M.,Wessler S.
Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Trends Biochem. Sci.
33
80-90
2008
18182299
127949
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
19413330
127950
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
19369195
127951
Vepachedu R.,Karim Z.,Patel O.,Goplen N.,Alam R.
Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
PLoS ONE
4
0-0
2009
19381274
127952
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
19690332
127953
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
20068231
127954
Colicelli J.
ABL tyrosine kinases: evolution of function, regulation, and specificity.
Sci. Signal.
3
0-0
2010
20841568
127955
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
21406692
127956
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
23186163
127957
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
24275569
127959
Salah E.,Ugochukwu E.,Barr A.J.,von Delft F.,Knapp S.,Elkins J.M.
Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.
J. Med. Chem.
54
2359-2367
2011
21417343
127960
Liu W.,MacGrath S.M.,Koleske A.J.,Boggon T.J.
Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.
Acta Crystallogr. F
68
154-158
2012
22297987
127961
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
17344846