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Sequence of VGFR1_HUMAN

EC Number:2.7.10.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
receptor protein-tyrosine kinase
P17948
Homo sapiens
1338
150769
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1

General information:

Sequence
show sequence in fasta format
   0 MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH LQCRGEAAHK
  60 WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN HTGFYSCKYL AVPTSKKKET
 120 ESAIYIFISD TGRPFVEMYS EIPEIIHMTE GRELVIPCRV TSPNITVTLK KFPLDTLIPD
 180 GKRIIWDSRK GFIISNATYK EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV
 240 KLLRGHTLVL NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK
 300 MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK RSYRLSMKVK
 360 AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA GNYTILLSIK QSNVFKNLTA
 420 TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ ILTCTAYGIP QPTIKWFWHP CNHNHSEARC
 480 DFCSNNEESF ILDADSNMGN RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK
 540 VGTVGRNISF YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM
 600 HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK KEITIRDQEA
 660 PYLLRNLSDH TVAISSSTTL DCHANGVPEP QITWFKNNHK IQQEPGIILG PGSSTLFIER
 720 VTEEDEGVYH CKATNQKGSV ESSAYLTVQG TSDKSNLELI TLTCTCVAAT LFWLLLTLFI
 780 RKMKRSSSEI KTDYLSIIMD PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK
 840 VVQASAFGIK KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK
 900 QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHMEP KKEKMEPGLE QGKKPRLDSV
 960 TSSESFASSG FQEDKSLSDV EEEEDSDGFY KEPITMEDLI SYSFQVARGM EFLSSRKCIH
1020 RDLAARNILL SENNVVKICD FGLARDIYKN PDYVRKGDTR LPLKWMAPES IFDKIYSTKS
1080 DVWSYGVLLW EIFSLGGSPY PGVQMDEDFC SRLREGMRMR APEYSTPEIY QIMLDCWHRD
1140 PKERPRFAEL VEKLGDLLQA NVQQDGKDYI PINAILTGNS GFTYSTPAFS EDFFKESISA
1200 PKFNSGSSDD VRYVNAFKFM SLERIKTFEE LLPNATSMFD DYQGDSSTLL ASPMLKRFTW
1260 TDSKPKASLK IDLRVTSKSK ESGLSDVSRP SFCHSSCGHV SEGKRRFTYD HAELERKIAC
1320 CSPPPDYNSV VLYSTPPI
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
116617
Shibuya M.,Yamaguchi S.,Yamane A.,Ikeda T.,Tojo A.,Matsushime H.,Sato M.
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.
Oncogene
5
519-524
1990
116618
Kendall R.L.,Thomas K.A.
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
Proc. Natl. Acad. Sci. U.S.A.
90
10705-10709
1993
116619
Herley M.T.,Yu Y.,Whitney R.G.,Sato J.D.
Characterization of the VEGF binding site on the Flt-1 receptor.
Biochem. Biophys. Res. Commun.
262
731-738
1999
116620
Jin P.,Zhang J.,Sumariwalla P.F.,Ni I.,Jorgensen B.,Crawford D.,Phillips S.,Feldmann M.,Shepard H.M.,Paleolog E.M.
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Arthritis Res. Ther.
10
0-0
2008
116621
Sela S.,Itin A.,Natanson-Yaron S.,Greenfield C.,Goldman-Wohl D.,Yagel S.,Keshet E.
A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia.
Circ. Res.
102
1566-1574
2008
116622
Mezquita B.,Mezquita J.,Pau M.,Mezquita C.
A novel intracellular isoform of VEGFR-1 activates Src and promotes cell invasion in MDA-MB-231 breast cancer cells.
J. Cell. Biochem.
110
732-742
2010
116625
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
116626
Dunham A.,Matthews L.H.,Burton J.,Ashurst J.L.,Howe K.L.,Ashcroft K.J.,Beare D.M.,Burford D.C.,Hunt S.E.,Griffiths-Jones S.,Jones M.C.,Keenan S.J.,Oliver K.,Scott C.E.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews D.T.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Bannerjee R.,Barlow K.F.,Bates K.,Beasley H.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burrill W.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.E.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.C.,Cobley V.,Collins J.E.,Corby N.,Coville G.J.,Deloukas P.,Dhami P.,Dunham I.,Dunn M.,Earthrowl M.E.,Ellington A.G.,Faulkner L.,Frankish A.G.,Frankland J.,French L.,Garner P.,Garnett J.,Gilbert J.G.R.,Gilson C.J.,Ghori J.,Grafham D.V.,Gribble S.M.,Griffiths C.,Hall R.E.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Howden P.J.,Huckle E.J.,Hunt P.J.,Hunt A.R.,Johnson C.,Johnson D.,Kay M.,Kimberley A.M.,King A.,Laird G.K.,Langford C.J.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Lloyd C.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,McLaren S.J.,McMurray A.,Milne S.,Moore M.J.F.,Nickerson T.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.M.,Rice C.M.,Searle S.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Steward C.A.,Sycamore N.,Tester J.,Thomas D.W.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Wilming L.,Wray P.W.,Wright M.W.,Young L.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Beck S.,Bentley D.R.,Rogers J.,Ross M.T.
The DNA sequence and analysis of human chromosome 13.
Nature
428
522-528
2004
116628
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
116629
Matsushime H.,Yoshida M.C.,Sasaki M.,Shibuya M.
A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13.
Jpn. J. Cancer Res.
78
655-661
1987
116630
Ito N.,Wernstedt C.,Engstrom U.,Claesson-Welsh L.
Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.
J. Biol. Chem.
273
23410-23418
1998
116631
Seetharam L.,Gotoh N.,Maru Y.,Neufeld G.,Yamaguchi S.,Shibuya M.
A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.
Oncogene
10
135-147
1995
116632
Barleon B.,Sozzani S.,Zhou D.,Weich H.A.,Mantovani A.,Marme D.
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1.
Blood
87
3336-3343
1996
116633
Sawano A.,Takahashi T.,Yamaguchi S.,Shibuya M.
The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.
Biochem. Biophys. Res. Commun.
238
487-491
1997
116634
Igarashi K.,Isohara T.,Kato T.,Shigeta K.,Yamano T.,Uno I.
Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.
Biochem. Biophys. Res. Commun.
246
95-99
1998
116635
Dunk C.,Ahmed A.
Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells.
Am. J. Pathol.
158
265-273
2001
116636
Yu Y.,Hulmes J.D.,Herley M.T.,Whitney R.G.,Crabb J.W.,Sato J.D.
Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding.
Biochem. J.
358
465-472
2001
116637
Angelucci C.,Lama G.,Iacopino F.,Maglione D.,Sica G.
Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor.
Growth Factors
19
193-206
2001
116638
Huang K.,Andersson C.,Roomans G.M.,Ito N.,Claesson-Welsh L.
Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers.
Int. J. Biochem. Cell Biol.
33
315-324
2001
116639
Cai J.,Ahmad S.,Jiang W.G.,Huang J.,Kontos C.D.,Boulton M.,Ahmed A.
Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.
Diabetes
52
2959-2968
2003
116640
Autiero M.,Waltenberger J.,Communi D.,Kranz A.,Moons L.,Lambrechts D.,Kroll J.,Plaisance S.,De Mol M.,Bono F.,Kliche S.,Fellbrich G.,Ballmer-Hofer K.,Maglione D.,Mayr-Beyrle U.,Dewerchin M.,Dombrowski S.,Stanimirovic D.,Van Hummelen P.,Dehio C.,Hicklin D.J.,Persico G.,Herbert J.M.,Communi D.,Shibuya M.,Collen D.,Conway E.M.,Carmeliet P.
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
Nat. Med.
9
936-943
2003
116641
Kobayashi S.,Sawano A.,Nojima Y.,Shibuya M.,Maru Y.
The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).
FASEB J.
18
929-931
2004
116642
Fan F.,Wey J.S.,McCarty M.F.,Belcheva A.,Liu W.,Bauer T.W.,Somcio R.J.,Wu Y.,Hooper A.,Hicklin D.J.,Ellis L.M.
Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells.
Oncogene
24
2647-2653
2005
116643
Lesslie D.P.,Summy J.M.,Parikh N.U.,Fan F.,Trevino J.G.,Sawyer T.K.,Metcalf C.A.,Shakespeare W.C.,Hicklin D.J.,Ellis L.M.,Gallick G.E.
Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases.
Br. J. Cancer
94
1710-1717
2006
116644
Meyer R.D.,Mohammadi M.,Rahimi N.
A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1.
J. Biol. Chem.
281
867-875
2006
116645
Tchaikovski V.,Fellbrich G.,Waltenberger J.
The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes.
Arterioscler. Thromb. Vasc. Biol.
28
322-328
2008
116646
Nishi J.,Minamino T.,Miyauchi H.,Nojima A.,Tateno K.,Okada S.,Orimo M.,Moriya J.,Fong G.H.,Sunagawa K.,Shibuya M.,Komuro I.
Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt.
Circ. Res.
103
261-268
2008
116647
Taylor A.P.,Leon E.,Goldenberg D.M.
Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement.
Br. J. Cancer
103
82-89
2010
116648
Wang F.,Yamauchi M.,Muramatsu M.,Osawa T.,Tsuchida R.,Shibuya M.
RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway.
J. Biol. Chem.
286
9097-9106
2011
116649
Cai J.,Chen Z.,Ruan Q.,Han S.,Liu L.,Qi X.,Boye S.L.,Hauswirth W.W.,Grant M.B.,Boulton M.E.
gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
J. Biol. Chem.
286
42514-42523
2011
116650
Ahmad S.,Hewett P.W.,Al-Ani B.,Sissaoui S.,Fujisawa T.,Cudmore M.J.,Ahmed A.
Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis.
Vasc. Cell
3
15-15
2011
116651
Shibuya M.
Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.
J. Biochem. Mol. Biol.
39
469-478
2006
116652
Roskoski R. Jr.
VEGF receptor protein-tyrosine kinases: structure and regulation.
Biochem. Biophys. Res. Commun.
375
287-291
2008
116653
Lohela M.,Bry M.,Tammela T.,Alitalo K.
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.
Curr. Opin. Cell Biol.
21
154-165
2009
116654
Grunewald F.S.,Prota A.E.,Giese A.,Ballmer-Hofer K.
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.
Biochim. Biophys. Acta
1804
567-580
2010
116655
Schwartz J.D.,Rowinsky E.K.,Youssoufian H.,Pytowski B.,Wu Y.
Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1).
Cancer
116
1027-1032
2010
116656
Koch S.,Tugues S.,Li X.,Gualandi L.,Claesson-Welsh L.
Signal transduction by vascular endothelial growth factor receptors.
Biochem. J.
437
169-183
2011
116657
Shibuya M.
Involvement of Flt-1 (VEGF receptor-1) in cancer and preeclampsia.
Proc. Jpn. Acad., B, Phys. Biol. Sci.
87
167-178
2011
116658
Wiesmann C.,Fuh G.,Christinger H.W.,Eigenbrot C.,Wells J.A.,de Vos A.M.
Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell
91
695-704
1997
116659
Starovasnik M.A.,Christinger H.W.,Wiesmann C.,Champe M.A.,de Vos A.M.,Skelton N.J.
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J. Mol. Biol.
293
531-544
1999
116660
Christinger H.W.,Fuh G.,de Vos A.M.,Wiesmann C.
The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J. Biol. Chem.
279
10382-10388
2004
116661
Iyer S.,Darley P.I.,Acharya K.R.
Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity.
J. Biol. Chem.
285
23779-23789
2010
116662
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007