Sequence of TYLF_STRFR
EC Number:2.1.1.101
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin
Other sequences found for EC No. 2.1.1.101
General information:
Sequence
0 MAPSPDHARD LYIELLKKVV SNVIYEDPTH VAGMITDASF DRTSRESGED YPTVAHTMIG
60 LKRLDNLHRC LADVVEDGVP GDFIETGVWR GGACIFARGL LNAYGQADRT VWVADSFQGF
120 PELTGSDHPL DVEIDLHQYN EAVDLPTSEE TVRENFARYG LLDDNVRFLA GWFKDTMPAA
180 PVKQLAVMRL DGDSYGATMD VLDSLYERLS PGGYVIVDDY CIPACREAVH DFRDRLGIRD
240 TIHRIDRQGA YWRHSG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
113399
Bate N.,Cundliffe E.
The mycinose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
J. Ind. Microbiol. Biotechnol.
23
118-122
1999
113400
Fouces R.,Mellado E.,Diez B.,Barredo J.L.
The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region.
Microbiology
145
855-868
1999
113401
Fishman S.E.,Cox K.,Larson J.L.,Reynolds P.A.,Seno E.T.,Yeh W.K.,Van Frank R.,Hershberger C.L.
Cloning genes for the biosynthesis of a macrolide antibiotic.
Proc. Natl. Acad. Sci. U.S.A.
84
8248-8252
1987
113402
Bauer N.J.,Kreuzman A.J.,Dotzlaf J.E.,Yeh W.K.
Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae.
J. Biol. Chem.
263
15619-15625
1988
113403
Kreuzman A.J.,Turner J.R.,Yeh W.K.
Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.
J. Biol. Chem.
263
15626-15633
1988
