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Sequence of TPH2_HUMAN

EC Number:1.14.16.4

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
tryptophan 5-monooxygenase
Q8IWU9
Homo sapiens
490
56057
Reaction
L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Other sequences found for EC No. 1.14.16.4

General information:

Sequence
show sequence in fasta format
  0 MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGSSTLNKPN SGKNDDKGNK GSSKREAATE
 60 SGKTAVVFSL KNEVGGLVKA LRLFQEKRVN MVHIESRKSR RRSSEVEIFV DCECGKTEFN
120 ELIQLLKFQT TIVTLNPPEN IWTEEEELED VPWFPRKISE LDKCSHRVLM YGSELDADHP
180 GFKDNVYRQR RKYFVDVAMG YKYGQPIPRV EYTEEETKTW GVVFRELSKL YPTHACREYL
240 KNFPLLTKYC GYREDNVPQL EDVSMFLKER SGFTVRPVAG YLSPRDFLAG LAYRVFHCTQ
300 YIRHGSDPLY TPEPDTCHEL LGHVPLLADP KFAQFSQEIG LASLGASDED VQKLATCYFF
360 TIEFGLCKQE GQLRAYGAGL LSSIGELKHA LSDKACVKAF DPKTTCLQEC LITTFQEAYF
420 VSESFEEAKE KMRDFAKSIT RPFSVYFNPY TQSIEILKDT RSIENVVQDL RSDLNTVCDA
480 LNKMNQYLGI
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
110716
Walther D.J.,Peter J.-U.,Bashammakh S.,Hortnagl H.,Voits M.,Fink H.,Bader M.
Synthesis of serotonin by a second tryptophan hydroxylase isoform.
Science
299
76-76
2003
110717
Scherer S.E.,Muzny D.M.,Buhay C.J.,Chen R.,Cree A.,Ding Y.,Dugan-Rocha S.,Gill R.,Gunaratne P.,Harris R.A.,Hawes A.C.,Hernandez J.,Hodgson A.V.,Hume J.,Jackson A.,Khan Z.M.,Kovar-Smith C.,Lewis L.R.,Lozado R.J.,Metzker M.L.,Milosavljevic A.,Miner G.R.,Montgomery K.T.,Morgan M.B.,Nazareth L.V.,Scott G.,Sodergren E.,Song X.-Z.,Steffen D.,Lovering R.C.,Wheeler D.A.,Worley K.C.,Yuan Y.,Zhang Z.,Adams C.Q.,Ansari-Lari M.A.,Ayele M.,Brown M.J.,Chen G.,Chen Z.,Clerc-Blankenburg K.P.,Davis C.,Delgado O.,Dinh H.H.,Draper H.,Gonzalez-Garay M.L.,Havlak P.,Jackson L.R.,Jacob L.S.,Kelly S.H.,Li L.,Li Z.,Liu J.,Liu W.,Lu J.,Maheshwari M.,Nguyen B.-V.,Okwuonu G.O.,Pasternak S.,Perez L.M.,Plopper F.J.H.,Santibanez J.,Shen H.,Tabor P.E.,Verduzco D.,Waldron L.,Wang Q.,Williams G.A.,Zhang J.,Zhou J.,Allen C.C.,Amin A.G.,Anyalebechi V.,Bailey M.,Barbaria J.A.,Bimage K.E.,Bryant N.P.,Burch P.E.,Burkett C.E.,Burrell K.L.,Calderon E.,Cardenas V.,Carter K.,Casias K.,Cavazos I.,Cavazos S.R.,Ceasar H.,Chacko J.,Chan S.N.,Chavez D.,Christopoulos C.,Chu J.,Cockrell R.,Cox C.D.,Dang M.,Dathorne S.R.,David R.,Davis C.M.,Davy-Carroll L.,Deshazo D.R.,Donlin J.E.,D'Souza L.,Eaves K.A.,Egan A.,Emery-Cohen A.J.,Escotto M.,Flagg N.,Forbes L.D.,Gabisi A.M.,Garza M.,Hamilton C.,Henderson N.,Hernandez O.,Hines S.,Hogues M.E.,Huang M.,Idlebird D.G.,Johnson R.,Jolivet A.,Jones S.,Kagan R.,King L.M.,Leal B.,Lebow H.,Lee S.,LeVan J.M.,Lewis L.C.,London P.,Lorensuhewa L.M.,Loulseged H.,Lovett D.A.,Lucier A.,Lucier R.L.,Ma J.,Madu R.C.,Mapua P.,Martindale A.D.,Martinez E.,Massey E.,Mawhiney S.,Meador M.G.,Mendez S.,Mercado C.,Mercado I.C.,Merritt C.E.,Miner Z.L.,Minja E.,Mitchell T.,Mohabbat F.,Mohabbat K.,Montgomery B.,Moore N.,Morris S.,Munidasa M.,Ngo R.N.,Nguyen N.B.,Nickerson E.,Nwaokelemeh O.O.,Nwokenkwo S.,Obregon M.,Oguh M.,Oragunye N.,Oviedo R.J.,Parish B.J.,Parker D.N.,Parrish J.,Parks K.L.,Paul H.A.,Payton B.A.,Perez A.,Perrin W.,Pickens A.,Primus E.L.,Pu L.-L.,Puazo M.,Quiles M.M.,Quiroz J.B.,Rabata D.,Reeves K.,Ruiz S.J.,Shao H.,Sisson I.,Sonaike T.,Sorelle R.P.,Sutton A.E.,Svatek A.F.,Svetz L.A.,Tamerisa K.S.,Taylor T.R.,Teague B.,Thomas N.,Thorn R.D.,Trejos Z.Y.,Trevino B.K.,Ukegbu O.N.,Urban J.B.,Vasquez L.I.,Vera V.A.,Villasana D.M.,Wang L.,Ward-Moore S.,Warren J.T.,Wei X.,White F.,Williamson A.L.,Wleczyk R.,Wooden H.S.,Wooden S.H.,Yen J.,Yoon L.,Yoon V.,Zorrilla S.E.,Nelson D.,Kucherlapati R.,Weinstock G.,Gibbs R.A.
The finished DNA sequence of human chromosome 12.
Nature
440
346-351
2006
110718
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
110719
Cichon S.,Winge I.,Mattheisen M.,Georgi A.,Karpushova A.,Freudenberg J.,Freudenberg-Hua Y.,Babadjanova G.,Van Den Bogaert A.,Abramova L.I.,Kapiletti S.,Knappskog P.M.,McKinney J.,Maier W.,Jamra R.A.,Schulze T.G.,Schumacher J.,Propping P.,Rietschel M.,Haavik J.,Noethen M.M.
Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.
Hum. Mol. Genet.
17
87-97
2008
110720
Grohmann M.,Hammer P.,Walther M.,Paulmann N.,Buttner A.,Eisenmenger W.,Baghai T.C.,Schule C.,Rupprecht R.,Bader M.,Bondy B.,Zill P.,Priller J.,Walther D.J.
Alternative splicing and extensive RNA editing of human TPH2 transcripts.
PLoS ONE
5
0-0
2010
110721
Zhang X.,Gainetdinov R.R.,Beaulieu J.-M.,Sotnikova T.D.,Burch L.H.,Williams R.B.,Schwartz D.A.,Krishnan K.R.R.,Caron M.G.
Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.
Neuron
45
11-16
2005
110722
McKinney J.,Johansson S.,Halmoy A.,Dramsdahl M.,Winge I.,Knappskog P.M.,Haavik J.
A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder.
Mol. Psychiatry
13
365-367
2008
110723
McKinney J.A.,Turel B.,Winge I.,Knappskog P.M.,Haavik J.
Functional properties of missense variants of human tryptophan hydroxylase 2.
Hum. Mutat.
30
787-794
2009