Sequence of MAAL_CLOTT

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
methylaspartate ammonia-lyase
Q05514
Clostridium tetanomorphum
413
45534
Reaction
L-threo-3-methylaspartate = mesaconate + NH3
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MKIVDVLCTP GLTGFYFDDQ RAIKKGAGHD GFTYTGSTVT EGFTQVRQKG ESISVLLVLE
 60 DGQVAHGDCA AVQYSGAGGR DPLFLAKDFI PVIEKEIAPK LIGREITNFK PMAEEFDKMT
120 VNGNRLHTAI RYGITQAILD AVAKTRKVTM AEVIRDEYNP GAEINAVPVF AQSGDDRYDN
180 VDKMIIKEAD VLPHALINNV EEKLGLKGEK LLEYVKWLRD RIIKLRVRED YAPIFHIDVY
240 GTIGAAFDVD IKAMADYIQT LAEAAKPFHL RIEGPMDVED RQKQMEAMRD LRAELDGRGV
300 DAELVADEWC NTVEDVKFFT DNKAGHMVQI KTPDLGGVNN IADAIMYCKA NGMGAYCGGT
360 CNETNRSAEV TTNIGMACGA RQVLAKPGMG VDEGMMIVKN EMNRVLALVG RRK
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1171285
Goda S.K.,Minton N.P.,Botting N.P.,Gani D.
Cloning, sequencing, and expression in Escherichia coli of the Clostridium tetanomorphum gene encoding beta-methylaspartase and characterization of the recombinant protein.
Biochemistry
31
10747-10756
1992
1171286
Brecht M.,Kellermann J.,Plueckthun A.
Cloning and sequencing of glutamate mutase component E from Clostridium tetanomorphum.
FEBS Lett.
319
84-89
1993
1171287
Holloway D.E.,Marsh E.N.G.
Cloning and sequencing of glutamate mutase component E from Clostridium tetanomorphum. Organization of the mut genes.
FEBS Lett.
317
44-48
1993
1171288
Marsh E.N.G.,Holloway D.E.
Cloning and sequencing of glutamate mutase component S from Clostridium tetanomorphum. Homologies with other cobalamin-dependent enzymes.
FEBS Lett.
310
167-170
1992
1171289
Barker H.A.,Smyth R.D.,Wilson R.M.,Weissbach H.
The purification and properties of beta-methylaspartase.
J. Biol. Chem.
234
320-328
1959
1171290
Raj H.,Weiner B.,Veetil V.P.,Reis C.R.,Quax W.J.,Janssen D.B.,Feringa B.L.,Poelarends G.J.
Alteration of the diastereoselectivity of 3-methylaspartate ammonia lyase by using structure-based mutagenesis.
ChemBioChem
10
2236-2245
2009
1171291
Asuncion M.,Blankenfeldt W.,Barlow J.N.,Gani D.,Naismith J.H.
The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step.
J. Biol. Chem.
277
8306-8311
2002
1171292
Raj H.,Szymanski W.,de Villiers J.,Rozeboom H.J.,Veetil V.P.,Reis C.R.,de Villiers M.,Dekker F.J.,de Wildeman S.,Quax W.J.,Thunnissen A.M.,Feringa B.L.,Janssen D.B.,Poelarends G.J.
Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids.
Nat. Chem.
4
478-484
2012