Sequence of HPPE_STRWE

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
(S)-2-hydroxypropylphosphonic acid epoxidase
Q56185
Streptomyces wedmorensis
198
21337
Reaction
(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-1,2-epoxypropylphosphonate + 2 H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSNTKTASTG FAELLKDRRE QVKMDHAALA SLLGETPETV AAWENGEGGE LTLTQLGRIA
 60 HVLGTSIGAL TPPAGNDLDD GVIIQMPDER PILKGVRDNV DYYVYNCLVR TKRAPSLVPL
120 VVDVLTDNPD DAKFNSGHAG NEFLFVLEGE IHMKWGDKEN PKEALLPTGA SMFVEEHVPH
180 AFTAAKGTGS AKLIAVNF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1143637
Hidaka T.,Goda M.,Kuzuyama T.,Takei N.,Hidaka M.,Seto H.
Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.
Mol. Gen. Genet.
249
274-280
1995
1143638
Cicchillo R.M.,Zhang H.,Blodgett J.A.,Whitteck J.T.,Li G.,Nair S.K.,van der Donk W.A.,Metcalf W.W.
An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis.
Nature
459
871-874
2009
1143639
Higgins L.J.,Yan F.,Liu P.,Liu H.W.,Drennan C.L.
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme.
Nature
437
838-844
2005
1143640
McLuskey K.,Cameron S.,Hammerschmidt F.,Hunter W.N.
Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism.
Proc. Natl. Acad. Sci. U.S.A.
102
14221-14226
2005
1143641
Yun D.,Dey M.,Higgins L.J.,Yan F.,Liu H.W.,Drennan C.L.
Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J. Am. Chem. Soc.
133
11262-11269
2011