Sequence of ATR_YEAST
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
P38111
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
2368
273342
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MESHVKYLDE LILAIKDLNS GVDSKVQIKK VPTDPSSSQE YAKSLKILNT LIRNLKDQRR
60 NNIMKNDTIF SKTVSALALL LEYNPFLLVM KDSNGNFEIQ RLIDDFLNIS VLNYDNYHRI
120 WFMRRKLGSW CKACVEFYGK PAKFQLTAHF ENTMNLYEQA LTEVLLGKTE LLKFYDTLKG
180 LYILLYWFTS EYSTFGNSIA FLDSSLGFTK FDFNFQRLIR IVLYVFDSCE LAALEYAEIQ
240 LKYISLVVDY VCNRTISTAL DAPALVCCEQ LKFVLTTMHH FLDNKYGLLD NDPTMAKGIL
300 RLYSLCISND FSKCFVDHFP IDQWADFSQS EHFPFTQLTN KALSIVYFDL KRRSLPVEAL
360 KYDNKFNIWV YQSEPDSSLK NVTSPFDDRY KQLEKLRLLV LKKFNKTERG TLLKYRVNQL
420 SPGFFQRAGN DFKLILNEAS VSIQTCFKTN NITRLTSWTV ILGRLACLES EKFSGTLPNS
480 TKDMDNWYVC HLCDIEKTGN PFVRINPNRP EAAGKSEIFR ILHSNFLSHP NIDEFSESLL
540 SGILFSLHRI FSHFQPPKLT DGNGQINKSF KLVQKCFMNS NRYLRLLSTR IIPLFNISDS
600 HNSEDEHTAT LIKFLQSQKL PVVKENLVIA WTQLTLTTSN DVFDTLLLKL IDIFNSDDYS
660 LRIMMTLQIK NMAKILKKTP YQLLSPILPV LLRQLGKNLV ERKVGFQNLI ELLGYSSKTI
720 LDIFQRYIIP YAIIQYKSDV LSEIAKIMCD GDTSLINQMK VNLLKKNSRQ IFAVALVKHG
780 LFSLDILETL FLNRAPTFDK GYITAYLPDY KTLAEITKLY KNSVTKDASD SENANMILCS
840 LRFLITNFEK DKRHGSKYKN INNWTDDQEQ AFQKKLQDNI LGIFQVFSSD IHDVEGRTTY
900 YEKLRVINGI SFLIIYAPKK SIISALAQIS ICLQTGLGLK EVRYEAFRCW HLLVRHLNDE
960 ELSTVIDSLI AFILQKWSEF NGKLRNIVYS ILDTLIKEKS DLILKLKPYT TLALVGKPEL
1020 GILARDGQFA RMVNKIRSTT DLIPIFANNL KSSNKYVINQ NLDDIEVYLR RKQTERSIDF
1080 TPKKVGQTSD ITLVLGALLD TSHKFRNLDK DLCEKCAKCI SMIGVLDVTK HEFKRTTYSE
1140 NEVYDLNDSV QTIKFLIWVI NDILVPAFWQ SENPSKQLFV ALVIQESLKY CGLSSESWDM
1200 NHKELYPNEA KLWEKFNSVS KTTIYPLLSS LYLAQSWKEY VPLKYPSNNF KEGYKIWVKR
1260 FTLDLLKTGT TENHPLHVFS SLIREDDGSL SNFLLPYISL DIIIKAEKGT PYADILNGII
1320 IEFDSIFTCN LEGMNNLQVD SLRMCYESIF RVFEYCKKWA TEFKQNYSKL HGTFIIKDTK
1380 TTNMLLRIDE FLRTTPSDLL AQRSLETDSF ERSALYLEQC YRQNPHDKNQ NGQLLKNLQI
1440 TYEEIGDIDS LDGVLRTFAT GNLVSKIEEL QYSENWKLAQ DCFNVLGKFS DDPKTTTRML
1500 KSMYDHQLYS QIISNSSFHS SDGKISLSPD VKEWYSIGLE AANLEGNVQT LKNWVEQIES
1560 LRNIDDREVL LQYNIAKALI AISNEDPLRT QKYIHNSFRL IGTNFITSSK ETTLLKKQNL
1620 LMKLHSLYDL SFLSSAKDKF EYKSNTTILD YRMERIGADF VPNHYILSMR KSFDQLKMNE
1680 QADADLGKTF FTLAQLARNN ARLDIASESL MHCLERRLPQ AELEFAEILW KQGENDRALK
1740 IVQEIHEKYQ ENSSVNARDR AAVLLKFTEW LDLSNNSASE QIIKQYQDIF QIDSKWDKPY
1800 YSIGLYYSRL LERKKAEGYI TNGRFEYRAI SYFLLAFEKN TAKVRENLPK VITFWLDIAA
1860 ASISEAPGNR KEMLSKATED ICSHVEEALQ HCPTYIWYFV LTQLLSRLLH SHQSSAQIIM
1920 HILLSLAVEY PSHILWYITA LVNSNSSKRV LRGKHILEKY RQHSQNPHDL VSSALDLTKA
1980 LTRVCLQDVK SITSRSGKSL EKDFKFDMNV APSAMVVPVR KNLDIISPLE SNSMRGYQPF
2040 RPVVSIIRFG SSYKVFSSLK KPKQLNIIGS DGNIYGIMCK KEDVRQDNQY MQFATTMDFL
2100 LSKDIASRKR SLGINIYSVL SLREDCGILE MVPNVVTLRS ILSTKYESLK IKYSLKSLHD
2160 RWQHTAVDGK LEFYMEQVDK FPPILYQWFL ENFPDPINWF NARNTYARSY AVMAMVGHIL
2220 GLGDRHCENI LLDIQTGKVL HVDFDCLFEK GKRLPVPEIV PFRLTPNLLD ALGIIGTEGT
2280 FKKSSEVTLA LMRKNEVALM NVIETIMYDR NMDHSIQKAL KVLRNKIRGI DPQDGLVLSV
2340 AGQTETLIQE ATSEDNLSKM YIGWLPFW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
9200
Kato R.,Ogawa H.
An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae.
Nucleic Acids Res.
22
3104-3112
1994
9201
Weinert T.A.,Kiser G.L.,Hartwell L.H.
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
Genes Dev.
8
652-665
1994
9202
Becam A.-M.,Cullin C.,Grzybowska E.,Lacroute F.,Nasr F.,Ozier-Kalogeropoulos O.,Palucha A.,Slonimski P.P.,Zagulski M.,Herbert C.J.
The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes.
Yeast
10
0-0
1994
9203
Feldmann H.,Aigle M.,Aljinovic G.,Andre B.,Baclet M.C.,Barthe C.,Baur A.,Becam A.-M.,Biteau N.,Boles E.,Brandt T.,Brendel M.,Brueckner M.,Bussereau F.,Christiansen C.,Contreras R.,Crouzet M.,Cziepluch C.,Demolis N.,Delaveau T.,Doignon F.,Domdey H.,Duesterhus S.,Dubois E.,Dujon B.,El Bakkoury M.,Entian K.-D.,Feuermann M.,Fiers W.,Fobo G.M.,Fritz C.,Gassenhuber J.,Glansdorff N.,Goffeau A.,Grivell L.A.,de Haan M.,Hein C.,Herbert C.J.,Hollenberg C.P.,Holmstroem K.,Jacq C.,Jacquet M.,Jauniaux J.-C.,Jonniaux J.-L.,Kallesoee T.,Kiesau P.,Kirchrath L.,Koetter P.,Korol S.,Liebl S.,Logghe M.,Lohan A.J.E.,Louis E.J.,Li Z.Y.,Maat M.J.,Mallet L.,Mannhaupt G.,Messenguy F.,Miosga T.,Molemans F.,Mueller S.,Nasr F.,Obermaier B.,Perea J.,Pierard A.,Piravandi E.,Pohl F.M.,Pohl T.M.,Potier S.,Proft M.,Purnelle B.,Ramezani Rad M.,Rieger M.,Rose M.,Schaaff-Gerstenschlaeger I.,Scherens B.,Schwarzlose C.,Skala J.,Slonimski P.P.,Smits P.H.M.,Souciet J.-L.,Steensma H.Y.,Stucka R.,Urrestarazu L.A.,van der Aart Q.J.M.,Van Dyck L.,Vassarotti A.,Vetter I.,Vierendeels F.,Vissers S.,Wagner G.,de Wergifosse P.,Wolfe K.H.,Zagulski M.,Zimmermann F.K.,Mewes H.-W.,Kleine K.
Complete DNA sequence of yeast chromosome II.
EMBO J.
13
5795-5809
1994
9204
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
9205
Sanchez Y.,Desany B.A.,Jones W.J.,Liu Q.,Wang B.,Elledge S.J.
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.
Science
271
357-360
1996
9206
Brush G.S.,Morrow D.M.,Hieter P.,Kelly T.J.
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.
Proc. Natl. Acad. Sci. U.S.A.
93
15075-15080
1996
9207
Rouse J.,Jackson S.P.
LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae.
EMBO J.
19
5801-5812
2000
9208
Paciotti V.,Clerici M.,Lucchini G.,Longhese M.P.
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast.
Genes Dev.
14
2046-2059
2000
9209
Downs J.A.,Lowndes N.F.,Jackson S.P.
A role for Saccharomyces cerevisiae histone H2A in DNA repair.
Nature
408
1001-1004
2000
9210
Mallory J.C.,Petes T.D.
Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.
Proc. Natl. Acad. Sci. U.S.A.
97
13749-13754
2000
9211
Paciotti V.,Clerici M.,Scotti M.,Lucchini G.,Longhese M.P.
Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway.
Mol. Cell. Biol.
21
3913-3925
2001
9212
Enomoto S.,Glowczewski L.,Berman J.
MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.
Mol. Biol. Cell
13
2626-2638
2002
9213
Redon C.,Pilch D.R.,Rogakou E.P.,Orr A.H.,Lowndes N.F.,Bonner W.M.
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage.
EMBO Rep.
4
678-684
2003
9214
Lisby M.,Barlow J.H.,Burgess R.C.,Rothstein R.
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.
Cell
118
699-713
2004
9215
Shroff R.,Arbel-Eden A.,Pilch D.R.,Ira G.,Bonner W.M.,Petrini J.H.J.,Haber J.E.,Lichten M.
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break.
Curr. Biol.
14
1703-1711
2004
9216
Rouse J.
Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage.
EMBO J.
23
1188-1197
2004
9217
Flott S.,Rouse J.
Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage.
Biochem. J.
391
325-333
2005
9218
Ma J.-L.,Lee S.-J.,Duong J.K.,Stern D.F.
Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1.
J. Biol. Chem.
281
3954-3963
2006
9219
Nakada D.,Hirano Y.,Tanaka Y.,Sugimoto K.
Role of the C-terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.
Mol. Biol. Cell
16
5227-5235
2005
9220
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
